HEADER RECORD*******LIBRARY HEADER RECORD!!!!!!!000000000000000000000000000000 SAS SAS SASLIB 6.06 MAC1. 26AUG24:15:47:1526AUG24:15:47:15 HEADER RECORD*******MEMBER HEADER RECORD!!!!!!!000000000000000001600000000140 HEADER RECORD*******DSCRPTR HEADER RECORD!!!!!!!000000000000000000000000000000 SAS ADTTRE2 SASDATA 6.06 26AUG24:15:47:1526AUG24:15:47:15 Recurrent of Symptom Analysis Dataset HEADER RECORD*******NAMESTR HEADER RECORD!!!!!!!000000010000000000000000000000 STUDYID Study Identifier USUBJID Unique Subject Identifier SUBJID Subject Identifier for the Study -SITEID Study Site Identifier 6COUNTRY Country ;AGE Age BEST >AGEU Age Units F"STRATAR Strata Used for Randomization K STRATARNStrata Used for Randomization (N) BEST m AGEGR1 Pooled Age Group 1 uAGEGR1N Pooled Age Group 1 (N) BEST ‡AGEGR2 Pooled Age Group 2 AGEGR2N Pooled Age Group 2 (N) BEST ¡AGEGR3 Pooled Age Group 3 ©AGEGR3N Pooled Age Group 3 (N) BEST »AGEGR4 Pooled Age Group 4 ÃAGEGR4N Pooled Age Group 4 (N) BEST ÖSEX Sex Þ RACE Race ß>RACESPY Race Specify ÿETHNIC Ethnicity =RANDFL Randomized Population Flag SFASFL Full Analysis Set Population Flag TSAFFL Safety Population Flag USAR1FL First Solicited Safety Population Flag VSAR2FL Second Solicited Safety Population Flag WSARAFL Solicited Safety Population Flag XMITTFL Modified Intent to Treat Population Flag YPPROTFL Per-Protocol Population Flag ZRANDIGFLRandom Immunogenicity Subcohort Flag [PPSIFL Per-Protocol Random Subcohort for IG \ CCIASFL Case-Cohort IG Analysis Set Flag ]!DOSE1FL Vaccination 1 Flag ^"DOSE2FL Vaccination 2 Flag _#OLDOS1FLOL Vaccination 1 Flag `$OLDOS2FLOL Vaccination 2 Flag a%RTPCRBL Baseline RT-PCR Test b&ELECSBL Baseline Elecsys Sars Cov-2 Assay j'SCOV2BL Baseline SARS-CoV-2 Status r (TRT01P Planned Treatment for Period 01 z)TRT01PN Planned Treatment for Period 01 (N) BEST ƒ *TRT01A Actual Treatment for Period 01 ‹+TRT01AN Actual Treatment for Period 01 (N) BEST ” ,TRT02P Planned Treatment for Period 02 œ-TRT02PN Planned Treatment for Period 02 (N) BEST ¥ .TRT02A Actual Treatment for Period 02 /TRT02AN Actual Treatment for Period 02 (N) BEST ¶0TRTSEQP Planned Sequence of Treatments ¾1TRTSEQPNPlanned Sequence of Treatments (N) BEST Ï2TRTSEQA Actual Sequence of Treatments ×3TRTSEQANActual Sequence of Treatments (N) BEST è4TRTSDT Date of First Exposure to Treatment DATE ð5TRTEDT Date of Last Exposure to Treatment DATE ø6TR01SDT Date of First Exposure in Period 01 DATE 7TR01SDTMDatetime of First Exposure in Period 01 DATETIME 8TR01EDT Date of Last Exposure in Period 01 DATE 9TR01EDTMDatetime of Last Exposure in Period 01 DATETIME :DOSE2DT Date of Dose 2 in Blinded Phase DATE ;DOS2DTM Datetime of Dose 2 in Blinded Phase DATETIME (TR02EDT Date of Last Exposure in Period 02 DATE @?TR02EDTMDatetime of Last Exposure in Period 02 DATETIME H@OLDOS2DTDate of Dose 2 in Open Label Phase DATE PAOLDO2DTMDatetime of Dose 2 in Open Label Phase DATETIME XBEUAVACDTDate of Post-EUA Off-Study COVID VaccineDATE `CEFFCODT Efficacy Date Cutoff Date DATE hDAP01SDT Period 01 Start Date DATE pEAP01EDT Period 01 End Date DATE xFAP02SDT Period 02 Start Date DATE €GAP02EDT Period 02 End Date DATE ˆHAP01SSDTPeriod 01 Start Date for Safety AnalysisDATE IAP01SEDTPeriod 01 End Date for Safety Analysis DATE ˜JAP02SSDTPeriod 02 Start Date for Safety AnalysisDATE KAP02SEDTPeriod 02 End Date for Safety Analysis DATE ¨LRSKF1 Risk Factor 1 °MRSKF2 Risk Factor 2 ÄNRSKF3 Risk Factor 3 ßORSKF4 Risk Factor 4 í PRSKF5 Risk Factor 5 õ&QRSKF6 Risk Factor 6 "RSTRATAV Strata from Verification Source (SSTRATAVNStrata from Verification Source (N) BEST JTSTUDDUR3Study Duration 3 BEST RUMINORITYMinority Z VRACEGR1 Pooled Race Group 1 fWRACEGR1NPooled Race Group 1 (N) BEST sXRISKGR1 Pooled Risk Group 1 {YRISKGR1NPooled Risk Group 1 (N) BEST †ZRETHGR1 Pooled Race and Ethnicity Group 1 Ž[RETHGR1NPooled Race and Ethnicity Group 1 (N) BEST ¢\COVIDAFLCOVID-19 Based on Adjudication Flag ª]CVDSVAFLSevere COVID-19 Based on Adj Flag «^PARAM Parameter ¬_PARAMCD Parameter Code É`EVENTSEQEvent Sequence Number BEST ÑaCNSR Censor BEST Ù,bEVNTDESCEvent or Censoring Description ácSTARTVALAnalysis Start Value BEST dAVAL Analysis Value BEST HEADER RECORD*******OBS HEADER RECORD!!!!!!!000000000000000000000000000000 mRNA-1273-P301 mRNA-1273-P301-US368-2179US3682179US368USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWVDV®HrG¨DVÊHrkëDVÊHrkëDW7Hrû°àDWVHs$gÄDWVHs$gÄ.DW]DV®DW6DW7.DV®DW6DW7. >=18 and <65 Years and Not at RiskAB”Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B`mRNA-1273-P301 mRNA-1273-P301-US368-2179US3682179US368USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWVDV®HrG¨DVÊHrkëDVÊHrkëDW7Hrû°àDWVHs$gÄDWVHs$gÄ.DW]DV®DW6DW7.DV®DW6DW7. >=18 and <65 Years and Not at RiskAB”Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B`B`mômRNA-1273-P301 mRNA-1273-P301-US368-2179US3682179US368USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWVDV®HrG¨DVÊHrkëDVÊHrkëDW7Hrû°àDWVHs$gÄDWVHs$gÄ.DW]DV®DW6DW7.DV®DW6DW7. >=18 and <65 Years and Not at RiskAB”Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B`môB`ÛèmRNA-1273-P301 mRNA-1273-P301-US368-2179US3682179US368USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWVDV®HrG¨DVÊHrkëDVÊHrkëDW7Hrû°àDWVHs$gÄDWVHs$gÄ.DW]DV®DW6DW7.DV®DW6DW7. >=18 and <65 Years and Not at RiskAB”Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B`ÛèB`IÜmRNA-1273-P301 mRNA-1273-P301-US393-2118US3932118US393USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FMULTIPLE (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWGDVšHr,¨DV³HrMõàDV³HrMõàDWGHsÖxDWGHsÖx...DW]DVšDWFDWG.DVšDWFDWG. >=18 and <65 Years and Not at RiskAB«Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BsmRNA-1273-P301 mRNA-1273-P301-US393-2118US3932118US393USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FMULTIPLE (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWGDVšHr,¨DV³HrMõàDV³HrMõàDWGHsÖxDWGHsÖx...DW]DVšDWFDWG.DVšDWFDWG. >=18 and <65 Years and Not at RiskAB«Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BsBsmômRNA-1273-P301 mRNA-1273-P301-US393-2118US3932118US393USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FMULTIPLE (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWGDVšHr,¨DV³HrMõàDV³HrMõàDWGHsÖxDWGHsÖx...DW]DVšDWFDWG.DVšDWFDWG. >=18 and <65 Years and Not at RiskAB«Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BsmôBsÛèmRNA-1273-P301 mRNA-1273-P301-US393-2118US3932118US393USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FMULTIPLE (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWGDVšHr,¨DV³HrMõàDV³HrMõàDWGHsÖxDWGHsÖx...DW]DVšDWFDWG.DVšDWFDWG. >=18 and <65 Years and Not at RiskAB«Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BsÛèBsIÜmRNA-1273-P301 mRNA-1273-P301-US343-2216US3432216US343USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWHDVƒHrDV Hr4¬èDV Hr4¬èDW/HrñüDWHHsÔDWHHsÔ.DW]DVƒDW.DW/.DVƒDW.DW/. >=18 and <65 Years and Not at RiskAB¾Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBŽmRNA-1273-P301 mRNA-1273-P301-US343-2216US3432216US343USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWHDVƒHrDV Hr4¬èDV Hr4¬èDW/HrñüDWHHsÔDWHHsÔ.DW]DVƒDW.DW/.DVƒDW.DW/. >=18 and <65 Years and Not at RiskAB¾Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBŽBŽmðmRNA-1273-P301 mRNA-1273-P301-US378-2050US3782050US378USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW%DV‚Hr <DVžHr2ðDVžHr2ðDW HrÀL€DW%Hrä!xDW%Hrä!x.DW]DV‚DW DW .DV‚DW DW . >=18 and <65 Years and Not at RiskABÀNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B=mRNA-1273-P301 mRNA-1273-P301-US378-2050US3782050US378USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW%DV‚Hr <DVžHr2ðDVžHr2ðDW HrÀL€DW%Hrä!xDW%Hrä!x.DW]DV‚DW DW .DV‚DW DW . >=18 and <65 Years and Not at RiskABÀNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B=B=mômRNA-1273-P301 mRNA-1273-P301-US378-2050US3782050US378USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW%DV‚Hr <DVžHr2ðDVžHr2ðDW HrÀL€DW%Hrä!xDW%Hrä!x.DW]DV‚DW DW .DV‚DW DW . >=18 and <65 Years and Not at RiskABÀNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B=môB=ÛæmRNA-1273-P301 mRNA-1273-P301-US378-2050US3782050US378USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW%DV‚Hr <DVžHr2ðDVžHr2ðDW HrÀL€DW%Hrä!xDW%Hrä!x.DW]DV‚DW DW .DV‚DW DW . >=18 and <65 Years and Not at RiskABÀNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B=ÛæB=IÚmRNA-1273-P301 mRNA-1273-P301-US377-2162US3772162US377USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW:DVŠHr×€DV§Hr=ú DV§Hr=ú DWHrÙ^ÜDW:HrÿžXDW:HrÿžX.DW]DVŠDWDW.DVŠDWDW.Chronic Lung Disease >=65 Years A0B·Non-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBcmRNA-1273-P301 mRNA-1273-P301-US377-2162US3772162US377USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW:DVŠHr×€DV§Hr=ú DV§Hr=ú DWHrÙ^ÜDW:HrÿžXDW:HrÿžX.DW]DVŠDWDW.DVŠDWDW.Chronic Lung Disease >=65 Years A0B·Non-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBcBcmômRNA-1273-P301 mRNA-1273-P301-US380-2185US3802185US380USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW,DV—Hr(¿xDV¸HrTtˆDV¸HrTtˆDWHrÈÈDW,HríØDW,HríØ.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB¦Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BBmRNA-1273-P301 mRNA-1273-P301-US380-2185US3802185US380USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW,DV—Hr(¿xDV¸HrTtˆDV¸HrTtˆDWHrÈÈDW,HríØDW,HríØ.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB¦Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BBBBmômRNA-1273-P301 mRNA-1273-P301-US380-2185US3802185US380USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW,DV—Hr(¿xDV¸HrTtˆDV¸HrTtˆDWHrÈÈDW,HríØDW,HríØ.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB¦Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BBmôBBÛèmRNA-1273-P301 mRNA-1273-P301-US380-2185US3802185US380USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW,DV—Hr(¿xDV¸HrTtˆDV¸HrTtˆDWHrÈÈDW,HríØDW,HríØ.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB¦Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BBÛèBBIÜmRNA-1273-P301 mRNA-1273-P301-US343-2615US3432615US343USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV¼DVÕDV¼HrY üDVÕHrzk DVÕHrzk .......DW]DV¼DW$DW%.DV¼DW$DW%. Significant Cardiac DiseaseSevere ObesityDiabetes >=18 and <65 Years and at Risk A B‰Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBNmRNA-1273-P301 mRNA-1273-P301-US343-2615US3432615US343USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV¼DVÕDV¼HrY üDVÕHrzk DVÕHrzk .......DW]DV¼DW$DW%.DV¼DW$DW%. Significant Cardiac DiseaseSevere ObesityDiabetes >=18 and <65 Years and at Risk A B‰Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBNBNmômRNA-1273-P301 mRNA-1273-P301-US366-2124US3662124US366USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV£DVÀDV£Hr8¸ØDVÀHr^âÄDVÀHr^âÄ.......DW]DV£DW0DW1.DV£DW0DW1. >=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BkmRNA-1273-P301 mRNA-1273-P301-US366-2124US3662124US366USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV£DVÀDV£Hr8¸ØDVÀHr^âÄDVÀHr^âÄ.......DW]DV£DW0DW1.DV£DW0DW1. >=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BkBkmômRNA-1273-P301 mRNA-1273-P301-US366-2124US3662124US366USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV£DVÀDV£Hr8¸ØDVÀHr^âÄDVÀHr^âÄ.......DW]DV£DW0DW1.DV£DW0DW1. >=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BkmôBkÛèmRNA-1273-P301 mRNA-1273-P301-US366-2124US3662124US366USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV£DVÀDV£Hr8¸ØDVÀHr^âÄDVÀHr^âÄ.......DW]DV£DW0DW1.DV£DW0DW1. >=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BkÛèBkIÜmRNA-1273-P301 mRNA-1273-P301-US363-2109US3632109US363USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DW(DV¬HrD}øDVÊHrkþŒDVÊHrkþŒDW HrÄ=18 and <65 Years and Not at RiskAB”Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BAmRNA-1273-P301 mRNA-1273-P301-US363-2109US3632109US363USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DW(DV¬HrD}øDVÊHrkþŒDVÊHrkþŒDW HrÄ=18 and <65 Years and Not at RiskAB”Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BABAmômRNA-1273-P301 mRNA-1273-P301-US363-2109US3632109US363USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DW(DV¬HrD}øDVÊHrkþŒDVÊHrkþŒDW HrÄ=18 and <65 Years and Not at RiskAB”Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BAmôBAÛèmRNA-1273-P301 mRNA-1273-P301-US343-2449US3432449US343USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV“DWNDV“Hr#` DV¯HrHFhDV¯HrHFhDW1HróødDWNHsHDWNHsH.DW]DV“DW0DW1.DV“DW0DW1. >=18 and <65 Years and Not at RiskAB¯Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US343-2449US3432449US343USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV“DWNDV“Hr#` DV¯HrHFhDV¯HrHFhDW1HróødDWNHsHDWNHsH.DW]DV“DW0DW1.DV“DW0DW1. >=18 and <65 Years and Not at RiskAB¯Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmðmRNA-1273-P301 mRNA-1273-P301-US343-2449US3432449US343USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV“DWNDV“Hr#` DV¯HrHFhDV¯HrHFhDW1HróødDWNHsHDWNHsH.DW]DV“DW0DW1.DV“DW0DW1. >=18 and <65 Years and Not at RiskAB¯Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US368-2153US3682153US368USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DWADV£Hr8°àDV¿Hr] €DV¿Hr] €DW%HräPDWAHsýhDWAHsýh.DW]DV£DW$DW%.DV£DW$DW%.Chronic Lung Disease >=18 and <65 Years and at Risk A BŸMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BUmRNA-1273-P301 mRNA-1273-P301-US368-2153US3682153US368USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DWADV£Hr8°àDV¿Hr] €DV¿Hr] €DW%HräPDWAHsýhDWAHsýh.DW]DV£DW$DW%.DV£DW$DW%.Chronic Lung Disease >=18 and <65 Years and at Risk A BŸMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BUBUmômRNA-1273-P301 mRNA-1273-P301-US368-2153US3682153US368USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DWADV£Hr8°àDV¿Hr] €DV¿Hr] €DW%HräPDWAHsýhDWAHsýh.DW]DV£DW$DW%.DV£DW$DW%.Chronic Lung Disease >=18 and <65 Years and at Risk A BŸMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BUmôBUÛèmRNA-1273-P301 mRNA-1273-P301-US323-2137US3232137US323USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFOTHER (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW9DVHrJ4DV«HrBíäDV«HrBíäDWHrØ&èDW9HrþWdDW9HrþWd.DW]DVDWDW.DVDWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A B³Non-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US323-2137US3232137US323USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFOTHER (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW9DVHrJ4DV«HrBíäDV«HrBíäDWHrØ&èDW9HrþWdDW9HrþWd.DW]DVDWDW.DVDWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A B³Non-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmðmRNA-1273-P301 mRNA-1273-P301-US323-2137US3232137US323USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFOTHER (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW9DVHrJ4DV«HrBíäDV«HrBíäDWHrØ&èDW9HrþWdDW9HrþWd.DW]DVDWDW.DVDWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A B³Non-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US352-2307US3522307US352USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW9DV‡Hr†¨DV£Hr8idDV£Hr8idDWHrÙ…DW9HrþkŒDW9HrþkŒ.DW]DV‡DWDW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB»Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmRNA-1273-P301 mRNA-1273-P301-US352-2307US3522307US352USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW9DV‡Hr†¨DV£Hr8idDV£Hr8idDWHrÙ…DW9HrþkŒDW9HrþkŒ.DW]DV‡DWDW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB»Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBmómRNA-1273-P301 mRNA-1273-P301-US363-2094US3632094US363USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDW:DVŸHr3u¨DV¸HrTv¤DV¸HrTv¤DWHrÚ×€DW:HrÿØxDW:HrÿØx.DW]DVŸDWDW.DVŸDWDW. >=18 and <65 Years and Not at RiskAB¦Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B/mRNA-1273-P301 mRNA-1273-P301-US368-2015US3682015US368USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWADV‰Hr<,DV¤Hr9ÄDDV¤Hr9ÄDDW%Hrã×¤DWAHs¼|DWAHs¼|.DW]DV‰DW$DW%.DV‰DW$DW%. >=18 and <65 Years and Not at RiskABºMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BvmRNA-1273-P301 mRNA-1273-P301-US368-2015US3682015US368USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWADV‰Hr<,DV¤Hr9ÄDDV¤Hr9ÄDDW%Hrã×¤DWAHs¼|DWAHs¼|.DW]DV‰DW$DW%.DV‰DW$DW%. >=18 and <65 Years and Not at RiskABºMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BvBvmômRNA-1273-P301 mRNA-1273-P301-US368-2015US3682015US368USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWADV‰Hr<,DV¤Hr9ÄDDV¤Hr9ÄDDW%Hrã×¤DWAHs¼|DWAHs¼|.DW]DV‰DW$DW%.DV‰DW$DW%. >=18 and <65 Years and Not at RiskABºMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BvmôBvÛèmRNA-1273-P301 mRNA-1273-P301-US368-2015US3682015US368USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWADV‰Hr<,DV¤Hr9ÄDDV¤Hr9ÄDDW%Hrã×¤DWAHs¼|DWAHs¼|.DW]DV‰DW$DW%.DV‰DW$DW%. >=18 and <65 Years and Not at RiskABºMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BvÛèBvIÜmRNA-1273-P301 mRNA-1273-P301-US374-2408US3742408US374USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW/DV¦Hr<Ñ¬DVÂHraµDVÂHraµDWHrÌDDW/HrñDW/Hrñ.DW]DV¦DWDW.DV¦DWDW. >=18 and <65 Years and Not at RiskABœMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BJmRNA-1273-P301 mRNA-1273-P301-US374-2408US3742408US374USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW/DV¦Hr<Ñ¬DVÂHraµDVÂHraµDWHrÌDDW/HrñDW/Hrñ.DW]DV¦DWDW.DV¦DWDW. >=18 and <65 Years and Not at RiskABœMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BJBJmômRNA-1273-P301 mRNA-1273-P301-US374-2408US3742408US374USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW/DV¦Hr<Ñ¬DVÂHraµDVÂHraµDWHrÌDDW/HrñDW/Hrñ.DW]DV¦DWDW.DV¦DWDW. >=18 and <65 Years and Not at RiskABœMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BJmôBJÛèmRNA-1273-P301 mRNA-1273-P301-US366-2143US3662143US366USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DWVDV«HrC”DVÈHri-ØDVÈHri-ØDW:Hrÿ~´DWVHs$`€DWVHs$`€.DW]DV«DW9DW:.DV«DW9DW:. >=18 and <65 Years and Not at RiskAB–Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBvmRNA-1273-P301 mRNA-1273-P301-US366-2143US3662143US366USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DWVDV«HrC”DVÈHri-ØDVÈHri-ØDW:Hrÿ~´DWVHs$`€DWVHs$`€.DW]DV«DW9DW:.DV«DW9DW:. >=18 and <65 Years and Not at RiskAB–Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBvBvmômRNA-1273-P301 mRNA-1273-P301-US375-2229US3752229US375USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV£DV‡HrÖXDV£Hr8 <DV£Hr8 <......DVùDVùDV‡DVþDVÿDVÿDV‡DVþDVÿDVÿ >=18 and <65 Years and Not at RiskAB]Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B@mRNA-1273-P301 mRNA-1273-P301-US375-2229US3752229US375USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV£DV‡HrÖXDV£Hr8 <DV£Hr8 <......DVùDVùDV‡DVþDVÿDVÿDV‡DVþDVÿDVÿ >=18 and <65 Years and Not at RiskAB]Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B@B@mômRNA-1273-P301 mRNA-1273-P301-US375-2229US3752229US375USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV£DV‡HrÖXDV£Hr8 <DV£Hr8 <......DVùDVùDV‡DVþDVÿDVÿDV‡DVþDVÿDVÿ >=18 and <65 Years and Not at RiskAB]Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B@môB@ÛèmRNA-1273-P301 mRNA-1273-P301-US375-2229US3752229US375USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV£DV‡HrÖXDV£Hr8 <DV£Hr8 <......DVùDVùDV‡DVþDVÿDVÿDV‡DVþDVÿDVÿ >=18 and <65 Years and Not at RiskAB]Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B@ÛèB@IÜmRNA-1273-P301 mRNA-1273-P301-US349-2278US3492278US349USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DWGDV¬HrD¸DVÏHrrÀxDVÏHrrÀxDWGHsÀèDWGHsÀè...DW]DV¬DWFDWG.DV¬DWFDWG. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BomRNA-1273-P301 mRNA-1273-P301-US366-2156US3662156US366USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWVDV±HrK&DVÍHroý˜DVÍHroý˜DW2Hrõ àDWVHs$vÄDWVHs$vÄ.DW]DV±DW1DW2.DV±DW1DW2. >=18 and <65 Years and Not at RiskAB‘Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B2mRNA-1273-P301 mRNA-1273-P301-US366-2156US3662156US366USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWVDV±HrK&DVÍHroý˜DVÍHroý˜DW2Hrõ àDWVHs$vÄDWVHs$vÄ.DW]DV±DW1DW2.DV±DW1DW2. >=18 and <65 Years and Not at RiskAB‘Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B2B2mômRNA-1273-P301 mRNA-1273-P301-US366-2156US3662156US366USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWVDV±HrK&DVÍHroý˜DVÍHroý˜DW2Hrõ àDWVHs$vÄDWVHs$vÄ.DW]DV±DW1DW2.DV±DW1DW2. >=18 and <65 Years and Not at RiskAB‘Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B2môB2ÛæmRNA-1273-P301 mRNA-1273-P301-US366-2156US3662156US366USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWVDV±HrK&DVÍHroý˜DVÍHroý˜DW2Hrõ àDWVHs$vÄDWVHs$vÄ.DW]DV±DW1DW2.DV±DW1DW2. >=18 and <65 Years and Not at RiskAB‘Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B2ÛæB2IÚmRNA-1273-P301 mRNA-1273-P301-US304-2047US3042047US304USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) NOT HISPANIC OR LATINOYYYYYYYYYYYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDWODVrHq÷ÜŒDVHr†$DVHr†$DWOHswÌDWOHswÌ...DW]DVrDW=DW>.DVrDWNDWO. >=18 and <65 Years and Not at RiskABÎNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B¡mRNA-1273-P301 mRNA-1273-P301-US304-2047US3042047US304USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) NOT HISPANIC OR LATINOYYYYYYYYYYYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDWODVrHq÷ÜŒDVHr†$DVHr†$DWOHswÌDWOHswÌ...DW]DVrDW=DW>.DVrDWNDWO. >=18 and <65 Years and Not at RiskABÎNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B¡B¡mðmRNA-1273-P301 mRNA-1273-P301-US304-2047US3042047US304USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) NOT HISPANIC OR LATINOYYYYYYYYYYYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDWODVrHq÷ÜŒDVHr†$DVHr†$DWOHswÌDWOHswÌ...DW]DVrDW=DW>.DVrDWNDWO. >=18 and <65 Years and Not at RiskABÎNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B¡mðB¡ÛèmRNA-1273-P301 mRNA-1273-P301-US300-2165US3002165US300USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWHDV}HrdDV™Hr+O|DV™Hr+O|DW,HríWHDWHHs”DWHHs”.DW]DV}DW+DW,.DV}DW+DW,. >=18 and <65 Years and Not at RiskABÅMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmRNA-1273-P301 mRNA-1273-P301-US319-2704US3192704US319USAB@YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV“DWDDV“Hr#´LDV¯HrH¤dDV¯HrH¤dDW&Hrå/´DWDHsælDWDHsæl.DW]DV“DW%DW&.DV“DW%DW&. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B¯Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBBmRNA-1273-P301 mRNA-1273-P301-US319-2704US3192704US319USAB@YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV“DWDDV“Hr#´LDV¯HrH¤dDV¯HrH¤dDW&Hrå/´DWDHsælDWDHsæl.DW]DV“DW%DW&.DV“DW%DW&. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B¯Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBBBmômRNA-1273-P301 mRNA-1273-P301-US374-2273US3742273US374USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV“DWcDV“Hr#·ÐDV¯HrHðDV¯HrHðDWcHs5wXDWcHs5wX...DW]DV“DWFDWG.DV“DWbDWc. >=18 and <65 Years and Not at RiskAB¯Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BrmRNA-1273-P301 mRNA-1273-P301-US374-2273US3742273US374USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV“DWcDV“Hr#·ÐDV¯HrHðDV¯HrHðDWcHs5wXDWcHs5wX...DW]DV“DWFDWG.DV“DWbDWc. >=18 and <65 Years and Not at RiskAB¯Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BrBrmômRNA-1273-P301 mRNA-1273-P301-US374-2273US3742273US374USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV“DWcDV“Hr#·ÐDV¯HrHðDV¯HrHðDWcHs5wXDWcHs5wX...DW]DV“DWFDWG.DV“DWbDWc. >=18 and <65 Years and Not at RiskAB¯Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BrmôBrÛèmRNA-1273-P301 mRNA-1273-P301-US337-2086US3372086US337USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWYDVzHrª,DVHr0°4DVHr0°4DW=HsÃ DWYHs(päDWYHs(pä.DW]DVzDW<DW=.DVzDW<DW=. >=18 and <65 Years and Not at RiskABÁMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BœmRNA-1273-P301 mRNA-1273-P301-US363-2107US3632107US363USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW/DV¦Hr=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB=mRNA-1273-P301 mRNA-1273-P301-US363-2107US3632107US363USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MOTHER (b)(6) HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW/DV¦Hr=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB=B=mômRNA-1273-P301 mRNA-1273-P301-US348-2227US3482227US348USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV’DV®DV’Hr"TDV®HrFæ$DV®HrFæ$.......DW]DV’DW(DW).DV’DW(DW). >=18 and <65 Years and Not at RiskAB°Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B}mRNA-1273-P301 mRNA-1273-P301-US348-2286US3482286US348USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DWODV¹HrU{€DV×Hr|ðÔDV×Hr|ðÔDW1Hró©,DWOHsDWOHs.DW]DV¹DW0DW1.DV¹DW0DW1. >=18 and <65 Years and Not at RiskAB‡Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBWmRNA-1273-P301 mRNA-1273-P301-US348-2286US3482286US348USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DWODV¹HrU{€DV×Hr|ðÔDV×Hr|ðÔDW1Hró©,DWOHsDWOHs.DW]DV¹DW0DW1.DV¹DW0DW1. >=18 and <65 Years and Not at RiskAB‡Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBWBWmômRNA-1273-P301 mRNA-1273-P301-US363-2152US3632152US363USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MMULTIPLE (b)(6) NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW9DVÃHrbÀLDVÝHr…DVÝHr…DWHrÚ×øDW9Hrþ{DW9Hrþ{.DW]DVÃDWDW.DVÃDWDW. >=18 and <65 Years and Not at RiskABNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B=mRNA-1273-P301 mRNA-1273-P301-US300-2004US3002004US300USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW9DVkHqîËˆDV‡Hr DV‡Hr DWHrÚ”xDW9Hrþ9(DW9Hrþ9(.DW]DVkDWDW.DVkDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BOmRNA-1273-P301 mRNA-1273-P301-US300-2004US3002004US300USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW9DVkHqîËˆDV‡Hr DV‡Hr DWHrÚ”xDW9Hrþ9(DW9Hrþ9(.DW]DVkDWDW.DVkDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BOBOmômRNA-1273-P301 mRNA-1273-P301-US300-2004US3002004US300USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW9DVkHqîËˆDV‡Hr DV‡Hr DWHrÚ”xDW9Hrþ9(DW9Hrþ9(.DW]DVkDWDW.DVkDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BOmôBOÛèmRNA-1273-P301 mRNA-1273-P301-US300-2037US3002037US300USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVlDW]DVlHqðYøDV‰Hr`DV‰Hr`DW?Hs7|DW]Hs-ä DW]Hs-ä .DW]DVlDW/DW0.DVlDW>DW?. >=18 and <65 Years and Not at RiskABÕNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BbmRNA-1273-P301 mRNA-1273-P301-US300-2037US3002037US300USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVlDW]DVlHqðYøDV‰Hr`DV‰Hr`DW?Hs7|DW]Hs-ä DW]Hs-ä .DW]DVlDW/DW0.DVlDW>DW?. >=18 and <65 Years and Not at RiskABÕNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BbBbmômRNA-1273-P301 mRNA-1273-P301-US300-2037US3002037US300USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVlDW]DVlHqðYøDV‰Hr`DV‰Hr`DW?Hs7|DW]Hs-ä DW]Hs-ä .DW]DVlDW/DW0.DVlDW>DW?. >=18 and <65 Years and Not at RiskABÕNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BbmôBbÛèmRNA-1273-P301 mRNA-1273-P301-US300-2076US3002076US300USAB"YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW?DVoHqóþDV‹Hr$DV‹Hr$DWHrØ.¤DW?Hs|(DW?Hs|(.DW]DVoDWDW.DVoDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÓNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BlmRNA-1273-P301 mRNA-1273-P301-US300-2076US3002076US300USAB"YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW?DVoHqóþDV‹Hr$DV‹Hr$DWHrØ.¤DW?Hs|(DW?Hs|(.DW]DVoDWDW.DVoDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÓNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BlBlmômRNA-1273-P301 mRNA-1273-P301-US300-2076US3002076US300USAB"YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW?DVoHqóþDV‹Hr$DV‹Hr$DWHrØ.¤DW?Hs|(DW?Hs|(.DW]DVoDWDW.DVoDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÓNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BlmôBlÛèmRNA-1273-P301 mRNA-1273-P301-US300-2079US3002079US300USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW=DVoHqô2DV‹HrÁ¤DV‹HrÁ¤DW#HrábXDW=Hs¨¤DW=Hs¨¤.DW]DVoDWDW.DVoDW"DW#. >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBtmRNA-1273-P301 mRNA-1273-P301-US300-2079US3002079US300USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW=DVoHqô2DV‹HrÁ¤DV‹HrÁ¤DW#HrábXDW=Hs¨¤DW=Hs¨¤.DW]DVoDWDW.DVoDW"DW#. >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBtBtmômRNA-1273-P301 mRNA-1273-P301-US300-2081US3002081US300USAB!YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYYYYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVrDVŽDVrHq÷ãÐDVŽHr¥DDVŽHr¥D.......DW]DVrDWDW.DVrDWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBimRNA-1273-P301 mRNA-1273-P301-US300-2081US3002081US300USAB!YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYYYYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVrDVŽDVrHq÷ãÐDVŽHr¥DDVŽHr¥D.......DW]DVrDWDW.DVrDWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBiBimômRNA-1273-P301 mRNA-1273-P301-US300-2097US3002097US300USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW8DVsHqùdäDVHrLPDVHrLPDWHrÒºðDW8HrüùDW8Hrüù.DW]DVsDWDW.DVsDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B1mRNA-1273-P301 mRNA-1273-P301-US300-2097US3002097US300USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW8DVsHqùdäDVHrLPDVHrLPDWHrÒºðDW8HrüùDW8Hrüù.DW]DVsDWDW.DVsDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B1B1mômRNA-1273-P301 mRNA-1273-P301-US300-2097US3002097US300USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW8DVsHqùdäDVHrLPDVHrLPDWHrÒºðDW8HrüùDW8Hrüù.DW]DVsDWDW.DVsDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B1môB1ÛæmRNA-1273-P301 mRNA-1273-P301-US300-2106US3002106US300USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDV‘DVtHqúž¸DV‘Hr ¬ÀDV‘Hr ¬À.......DW]DVtDW=DW>.DVtDW=DW>. >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB\mRNA-1273-P301 mRNA-1273-P301-US300-2106US3002106US300USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDV‘DVtHqúž¸DV‘Hr ¬ÀDV‘Hr ¬À.......DW]DVtDW=DW>.DVtDW=DW>. >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB\B\mômRNA-1273-P301 mRNA-1273-P301-US300-2132US3002132US300USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVvDV’DVvHqý[€DV’Hr"OÐDV’Hr"OÐ.......DW]DVvDWDW.DVvDWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‹mRNA-1273-P301 mRNA-1273-P301-US300-2236US3002236US300USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHr (DV¬HrD‡XDV¬HrD‡XDW#Hrág¼DW?HsMüDW?HsMü.DW]DVDWDW.DVDW"DW#. >=18 and <65 Years and Not at RiskAB²Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BLmRNA-1273-P301 mRNA-1273-P301-US300-2236US3002236US300USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHr (DV¬HrD‡XDV¬HrD‡XDW#Hrág¼DW?HsMüDW?HsMü.DW]DVDWDW.DVDW"DW#. >=18 and <65 Years and Not at RiskAB²Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BLBLmômRNA-1273-P301 mRNA-1273-P301-US300-2236US3002236US300USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHr (DV¬HrD‡XDV¬HrD‡XDW#Hrág¼DW?HsMüDW?HsMü.DW]DVDWDW.DVDW"DW#. >=18 and <65 Years and Not at RiskAB²Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BLmôBLÛèmRNA-1273-P301 mRNA-1273-P301-US300-2260US3002260US300USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW8DV–Hr'fxDV²HrL„øDV²HrL„øDWHrØdDW8Hrý4DW8Hrý4.DW]DV–DWDW.DV–DWDW. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BUmRNA-1273-P301 mRNA-1273-P301-US300-2260US3002260US300USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW8DV–Hr'fxDV²HrL„øDV²HrL„øDWHrØdDW8Hrý4DW8Hrý4.DW]DV–DWDW.DV–DWDW. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BUBUmômRNA-1273-P301 mRNA-1273-P301-US300-2260US3002260US300USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW8DV–Hr'fxDV²HrL„øDV²HrL„øDWHrØdDW8Hrý4DW8Hrý4.DW]DV–DWDW.DV–DWDW. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BUmôBUÛèmRNA-1273-P301 mRNA-1273-P301-US300-2312US3002312US300USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDW:DVŸHr3€pDV»HrXj4DV»HrXj4DWHrØI\DW:HrÿÄÈDW:HrÿÄÈ.DW]DVŸDWDW.DVŸDWDW. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBXmRNA-1273-P301 mRNA-1273-P301-US300-2312US3002312US300USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDW:DVŸHr3€pDV»HrXj4DV»HrXj4DWHrØI\DW:HrÿÄÈDW:HrÿÄÈ.DW]DVŸDWDW.DVŸDWDW. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBXBXmômRNA-1273-P301 mRNA-1273-P301-US300-2334US3002334US300USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DWYDV«HrC1dDVÈHri{äDVÈHri{äDW@HsÔ8DWYHs({¬DWYHs({¬.DW]DV«DW/DW0.DV«DW?DW@. >=18 and <65 Years and Not at RiskAB–Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BemRNA-1273-P301 mRNA-1273-P301-US300-2334US3002334US300USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DWYDV«HrC1dDVÈHri{äDVÈHri{äDW@HsÔ8DWYHs({¬DWYHs({¬.DW]DV«DW/DW0.DV«DW?DW@. >=18 and <65 Years and Not at RiskAB–Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BeBemômRNA-1273-P301 mRNA-1273-P301-US300-2334US3002334US300USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DWYDV«HrC1dDVÈHri{äDVÈHri{äDW@HsÔ8DWYHs({¬DWYHs({¬.DW]DV«DW/DW0.DV«DW?DW@. >=18 and <65 Years and Not at RiskAB–Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BemôBeÛèmRNA-1273-P301 mRNA-1273-P301-US300-2334US3002334US300USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DWYDV«HrC1dDVÈHri{äDVÈHri{äDW@HsÔ8DWYHs({¬DWYHs({¬.DW]DV«DW/DW0.DV«DW?DW@. >=18 and <65 Years and Not at RiskAB–Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BeÛèBeIÜmRNA-1273-P301 mRNA-1273-P301-US300-2366US3002366US300USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¼DWYDV¼HrY¦ØDVØHr~‰”DVØHr~‰”DW@HsÕdDWYHs(¢XDWYHs(¢X.DW]DV¼DW.DW/.DV¼DW?DW@. >=18 and <65 Years and Not at RiskAB†Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B;mRNA-1273-P301 mRNA-1273-P301-US300-2366US3002366US300USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¼DWYDV¼HrY¦ØDVØHr~‰”DVØHr~‰”DW@HsÕdDWYHs(¢XDWYHs(¢X.DW]DV¼DW.DW/.DV¼DW?DW@. >=18 and <65 Years and Not at RiskAB†Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B;B;mômRNA-1273-P301 mRNA-1273-P301-US300-2366US3002366US300USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¼DWYDV¼HrY¦ØDVØHr~‰”DVØHr~‰”DW@HsÕdDWYHs(¢XDWYHs(¢X.DW]DV¼DW.DW/.DV¼DW?DW@. >=18 and <65 Years and Not at RiskAB†Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B;môB;ÛæmRNA-1273-P301 mRNA-1273-P301-US300-2366US3002366US300USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¼DWYDV¼HrY¦ØDVØHr~‰”DVØHr~‰”DW@HsÕdDWYHs(¢XDWYHs(¢X.DW]DV¼DW.DW/.DV¼DW?DW@. >=18 and <65 Years and Not at RiskAB†Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B;ÛæB;IÚmRNA-1273-P301 mRNA-1273-P301-US301-2028US3012028US301USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDWEDVmHqñphDV‰HrEÈDV‰HrEÈDWHrÙyXDWEHs6DWEHs6.DW]DVmDWDW.DVmDWDW. >=65 Years A0BÕNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‘mRNA-1273-P301 mRNA-1273-P301-US301-2114US3012114US301USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWLDVzHräDV—Hr)DV—Hr)DW(HrèÄDWLHs¦°DWLHs¦°.DW]DVzDWDW.DVzDW'DW(. >=18 and <65 Years and Not at RiskABÇMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BŽmRNA-1273-P301 mRNA-1273-P301-US301-2154US3012154US301USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW(DV}HrÔÐDV™Hr+´DV™Hr+´DWHrÆþDW(Hrè*ÔDW(Hrè*Ô.DW]DV}DWDW.DV}DWDW. Liver Disease >=18 and <65 Years and at Risk A BÅMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B#mRNA-1273-P301 mRNA-1273-P301-US301-2328US3012328US301USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWHDVHr0òÄDV¹HrU¿ðDV¹HrU¿ðDWHrÚØ4DWHHsG$DWHHsG$.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB¥Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B^mRNA-1273-P301 mRNA-1273-P301-US301-2328US3012328US301USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWHDVHr0òÄDV¹HrU¿ðDV¹HrU¿ðDWHrÚØ4DWHHsG$DWHHsG$.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB¥Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B^B^mômRNA-1273-P301 mRNA-1273-P301-US301-2328US3012328US301USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWHDVHr0òÄDV¹HrU¿ðDV¹HrU¿ðDWHrÚØ4DWHHsG$DWHHsG$.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB¥Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B^môB^ÛèmRNA-1273-P301 mRNA-1273-P301-US301-2329US3012329US301USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWFDVHr0ïDV¹HrUÛ\DV¹HrUÛ\DWFHsª´DWFHsª´...DW]DVDWEDWF.DVDWEDWF. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BxmRNA-1273-P301 mRNA-1273-P301-US301-2329US3012329US301USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWFDVHr0ïDV¹HrUÛ\DV¹HrUÛ\DWFHsª´DWFHsª´...DW]DVDWEDWF.DVDWEDWF. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BxBxmômRNA-1273-P301 mRNA-1273-P301-US301-2329US3012329US301USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWFDVHr0ïDV¹HrUÛ\DV¹HrUÛ\DWFHsª´DWFHsª´...DW]DVDWEDWF.DVDWEDWF. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BxmôBxÛèmRNA-1273-P301 mRNA-1273-P301-US301-2334US3012334US301USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DWFDV»HrXy4DVÝHr…6,DVÝHr…6,DWFHs¥DWFHs¥...DW]DV»DWEDWF.DV»DWEDWF. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BUmRNA-1273-P301 mRNA-1273-P301-US301-2334US3012334US301USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DWFDV»HrXy4DVÝHr…6,DVÝHr…6,DWFHs¥DWFHs¥...DW]DV»DWEDWF.DV»DWEDWF. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BUBUmômRNA-1273-P301 mRNA-1273-P301-US301-2334US3012334US301USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DWFDV»HrXy4DVÝHr…6,DVÝHr…6,DWFHs¥DWFHs¥...DW]DV»DWEDWF.DV»DWEDWF. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BUmôBUÛèmRNA-1273-P301 mRNA-1273-P301-US302-2223US3022223US302USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWFDVƒHr®ÐDVŸHr3ndDVŸHr3ndDW)Hré,¤DWFHs¦ôDWFHs¦ô.DW]DVƒDW(DW).DVƒDW(DW). >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B\mRNA-1273-P301 mRNA-1273-P301-US302-2223US3022223US302USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWFDVƒHr®ÐDVŸHr3ndDVŸHr3ndDW)Hré,¤DWFHs¦ôDWFHs¦ô.DW]DVƒDW(DW).DVƒDW(DW). >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B\B\mômRNA-1273-P301 mRNA-1273-P301-US302-2223US3022223US302USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWFDVƒHr®ÐDVŸHr3ndDVŸHr3ndDW)Hré,¤DWFHs¦ôDWFHs¦ô.DW]DVƒDW(DW).DVƒDW(DW). >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B\môB\ÛèmRNA-1273-P301 mRNA-1273-P301-US302-2223US3022223US302USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWFDVƒHr®ÐDVŸHr3ndDVŸHr3ndDW)Hré,¤DWFHs¦ôDWFHs¦ô.DW]DVƒDW(DW).DVƒDW(DW). >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B\ÛèB\IÜmRNA-1273-P301 mRNA-1273-P301-US302-2233US3022233US302USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWLDVƒHr¸¨DV¦Hr<ÂèDV¦Hr<ÂèDW"Hrà:TDWLHs‚˜DWLHs‚˜.DW]DVƒDW!DW".DVƒDW!DW". >=18 and <65 Years and Not at RiskAB¸Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB2mRNA-1273-P301 mRNA-1273-P301-US302-2233US3022233US302USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWLDVƒHr¸¨DV¦Hr<ÂèDV¦Hr<ÂèDW"Hrà:TDWLHs‚˜DWLHs‚˜.DW]DVƒDW!DW".DVƒDW!DW". >=18 and <65 Years and Not at RiskAB¸Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB2B2mômRNA-1273-P301 mRNA-1273-P301-US303-2004US3032004US303USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWZDVkHqîüüDVŠHrñDVŠHrñDW@HsÓHDWZHs*DWZHs*.DW]DVkDW?DW@.DVkDW?DW@. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B”mRNA-1273-P301 mRNA-1273-P301-US303-2004US3032004US303USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWZDVkHqîüüDVŠHrñDVŠHrñDW@HsÓHDWZHs*DWZHs*.DW]DVkDW?DW@.DVkDW?DW@. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B”B”mðmRNA-1273-P301 mRNA-1273-P301-US303-2004US3032004US303USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWZDVkHqîüüDVŠHrñDVŠHrñDW@HsÓHDWZHs*DWZHs*.DW]DVkDW?DW@.DVkDW?DW@. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B”mðB”ÛèmRNA-1273-P301 mRNA-1273-P301-US303-2004US3032004US303USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWZDVkHqîüüDVŠHrñDVŠHrñDW@HsÓHDWZHs*DWZHs*.DW]DVkDW?DW@.DVkDW?DW@. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B”ÛèB”IØmRNA-1273-P301 mRNA-1273-P301-US303-2009US3032009US303USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVlDVˆDVlHqð&hDVˆHrÖÀDVˆHrÖÀ.......DW]DVlDWDWDWDVlDWDWDW >=18 and <65 Years and Not at RiskABŒNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B\mRNA-1273-P301 mRNA-1273-P301-US303-2035US3032035US303USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW9DVmHqñHDV‰Hr’äDV‰Hr’äDWHrÖæHDW9Hrþˆ`DW9Hrþˆ`.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÕNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BnmRNA-1273-P301 mRNA-1273-P301-US303-2035US3032035US303USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW9DVmHqñHDV‰Hr’äDV‰Hr’äDWHrÖæHDW9Hrþˆ`DW9Hrþˆ`.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÕNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BnBnmômRNA-1273-P301 mRNA-1273-P301-US303-2035US3032035US303USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW9DVmHqñHDV‰Hr’äDV‰Hr’äDWHrÖæHDW9Hrþˆ`DW9Hrþˆ`.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÕNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BnmôBnÛèmRNA-1273-P301 mRNA-1273-P301-US303-2046US3032046US303USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDW@DVnHqòÀøDVHr”DVHr”DWHrÑ~DW@HsÉ4DW@HsÉ4.DW]DVnDWDW.DVnDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BQmRNA-1273-P301 mRNA-1273-P301-US303-2046US3032046US303USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDW@DVnHqòÀøDVHr”DVHr”DWHrÑ~DW@HsÉ4DW@HsÉ4.DW]DVnDWDW.DVnDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BQBQmômRNA-1273-P301 mRNA-1273-P301-US303-2046US3032046US303USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDW@DVnHqòÀøDVHr”DVHr”DWHrÑ~DW@HsÉ4DW@HsÉ4.DW]DVnDWDW.DVnDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BQmôBQÛèmRNA-1273-P301 mRNA-1273-P301-US303-2046US3032046US303USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDW@DVnHqòÀøDVHr”DVHr”DWHrÑ~DW@HsÉ4DW@HsÉ4.DW]DVnDWDW.DVnDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BQÛèBQIÜmRNA-1273-P301 mRNA-1273-P301-US303-2084US3032084US303USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWGDVsHqù‰8DVHrstDVHrstDW$HrâÑØDWGHsïŒDWGHsïŒ.DW]DVsDW#DW$.DVsDW#DW$. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BwmRNA-1273-P301 mRNA-1273-P301-US303-2084US3032084US303USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWGDVsHqù‰8DVHrstDVHrstDW$HrâÑØDWGHsïŒDWGHsïŒ.DW]DVsDW#DW$.DVsDW#DW$. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BwBwmômRNA-1273-P301 mRNA-1273-P301-US303-2084US3032084US303USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWGDVsHqù‰8DVHrstDVHrstDW$HrâÑØDWGHsïŒDWGHsïŒ.DW]DVsDW#DW$.DVsDW#DW$. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BwmôBwÛèmRNA-1273-P301 mRNA-1273-P301-US303-2095US3032095US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWNDVtHqúµ°DVHr†œDVHr†œDWNHsú<DWNHsú<...DW]DVtDWMDWN.DVtDWMDWN. Severe Obesity >=18 and <65 Years and at Risk A BÎMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BdmRNA-1273-P301 mRNA-1273-P301-US303-2095US3032095US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWNDVtHqúµ°DVHr†œDVHr†œDWNHsú<DWNHsú<...DW]DVtDWMDWN.DVtDWMDWN. Severe Obesity >=18 and <65 Years and at Risk A BÎMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BdBdmômRNA-1273-P301 mRNA-1273-P301-US303-2095US3032095US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWNDVtHqúµ°DVHr†œDVHr†œDWNHsú<DWNHsú<...DW]DVtDWMDWN.DVtDWMDWN. Severe Obesity >=18 and <65 Years and at Risk A BÎMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BdmôBdÛèmRNA-1273-P301 mRNA-1273-P301-US303-2095US3032095US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWNDVtHqúµ°DVHr†œDVHr†œDWNHsú<DWNHsú<...DW]DVtDWMDWN.DVtDWMDWN. Severe Obesity >=18 and <65 Years and at Risk A BÎMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BdÛèBdIÜmRNA-1273-P301 mRNA-1273-P301-US303-2109US3032109US303USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW9DVtHqû DV‘Hr! øDV‘Hr! øDWHrÕtèDW9Hrþp´DW9Hrþp´.DW]DVtDWDW.DVtDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÍNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BymRNA-1273-P301 mRNA-1273-P301-US303-2109US3032109US303USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW9DVtHqû DV‘Hr! øDV‘Hr! øDWHrÕtèDW9Hrþp´DW9Hrþp´.DW]DVtDWDW.DVtDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÍNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3ByBymômRNA-1273-P301 mRNA-1273-P301-US303-2109US3032109US303USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW9DVtHqû DV‘Hr! øDV‘Hr! øDWHrÕtèDW9Hrþp´DW9Hrþp´.DW]DVtDWDW.DVtDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÍNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BymôByÛèmRNA-1273-P301 mRNA-1273-P301-US303-2110US3032110US303USAB=YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWTDVtHqûDV–Hr'¢´DV–Hr'¢´DW9HrþXDWTHs!Õ,DWTHs!Õ,.DW]DVtDW8DW9.DVtDW8DW9. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BjmRNA-1273-P301 mRNA-1273-P301-US303-2110US3032110US303USAB=YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWTDVtHqûDV–Hr'¢´DV–Hr'¢´DW9HrþXDWTHs!Õ,DWTHs!Õ,.DW]DVtDW8DW9.DVtDW8DW9. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BjBjmômRNA-1273-P301 mRNA-1273-P301-US303-2110US3032110US303USAB=YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWTDVtHqûDV–Hr'¢´DV–Hr'¢´DW9HrþXDWTHs!Õ,DWTHs!Õ,.DW]DVtDW8DW9.DVtDW8DW9. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BjmôBjÛèmRNA-1273-P301 mRNA-1273-P301-US303-2113US3032113US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW9DVuHqûå4DV’Hr"%dDV’Hr"%dDWHrÕ‚DW9Hrþh€DW9Hrþh€.DW]DVuDWDW.DVuDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B6mRNA-1273-P301 mRNA-1273-P301-US303-2113US3032113US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW9DVuHqûå4DV’Hr"%dDV’Hr"%dDWHrÕ‚DW9Hrþh€DW9Hrþh€.DW]DVuDWDW.DVuDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B6B6mômRNA-1273-P301 mRNA-1273-P301-US303-2113US3032113US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW9DVuHqûå4DV’Hr"%dDV’Hr"%dDWHrÕ‚DW9Hrþh€DW9Hrþh€.DW]DVuDWDW.DVuDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B6môB6ÛæmRNA-1273-P301 mRNA-1273-P301-US303-2113US3032113US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW9DVuHqûå4DV’Hr"%dDV’Hr"%dDWHrÕ‚DW9Hrþh€DW9Hrþh€.DW]DVuDWDW.DVuDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B6ÛæB6IÚmRNA-1273-P301 mRNA-1273-P301-US303-2123US3032123US303USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW7DVuHqü´DV—Hr(¢àDV—Hr(¢àDWHrÖÌDW7Hrû“XDW7Hrû“X.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BgmRNA-1273-P301 mRNA-1273-P301-US303-2123US3032123US303USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW7DVuHqü´DV—Hr(¢àDV—Hr(¢àDWHrÖÌDW7Hrû“XDW7Hrû“X.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BgBgmômRNA-1273-P301 mRNA-1273-P301-US303-2123US3032123US303USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW7DVuHqü´DV—Hr(¢àDV—Hr(¢àDWHrÖÌDW7Hrû“XDW7Hrû“X.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BgmôBgÛèmRNA-1273-P301 mRNA-1273-P301-US303-2123US3032123US303USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW7DVuHqü´DV—Hr(¢àDV—Hr(¢àDWHrÖÌDW7Hrû“XDW7Hrû“X.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BgÛèBgIÜmRNA-1273-P301 mRNA-1273-P301-US303-2129US3032129US303USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW0DVuHqüBDV’Hr"*PDV’Hr"*PDWHrÍƒ´DW0Hrò‹´DW0Hrò‹´.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BwmRNA-1273-P301 mRNA-1273-P301-US303-2129US3032129US303USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW0DVuHqüBDV’Hr"*PDV’Hr"*PDWHrÍƒ´DW0Hrò‹´DW0Hrò‹´.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BwBwmômRNA-1273-P301 mRNA-1273-P301-US303-2129US3032129US303USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW0DVuHqüBDV’Hr"*PDV’Hr"*PDWHrÍƒ´DW0Hrò‹´DW0Hrò‹´.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BwmôBwÛèmRNA-1273-P301 mRNA-1273-P301-US303-2129US3032129US303USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW0DVuHqüBDV’Hr"*PDV’Hr"*PDWHrÍƒ´DW0Hrò‹´DW0Hrò‹´.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BwÛèBwIÜmRNA-1273-P301 mRNA-1273-P301-US303-2143US3032143US303USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWEDVvHqýQ¨DV–Hr'ˆìDV–Hr'ˆìDWHrÙ5$DWEHs ÷DWEHs ÷.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBtmRNA-1273-P301 mRNA-1273-P301-US303-2143US3032143US303USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWEDVvHqýQ¨DV–Hr'ˆìDV–Hr'ˆìDWHrÙ5$DWEHs ÷DWEHs ÷.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBtBtmômRNA-1273-P301 mRNA-1273-P301-US303-2185US3032185US303USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV—DVzHrŠˆDV—Hr(öDV—Hr(ö.......DW]DVz...DVz... >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BomRNA-1273-P301 mRNA-1273-P301-US303-2185US3032185US303USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV—DVzHrŠˆDV—Hr(öDV—Hr(ö.......DW]DVz...DVz... >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BoBomômRNA-1273-P301 mRNA-1273-P301-US303-2185US3032185US303USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV—DVzHrŠˆDV—Hr(öDV—Hr(ö.......DW]DVz...DVz... >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BomôBoÛèmRNA-1273-P301 mRNA-1273-P301-US303-2185US3032185US303USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV—DVzHrŠˆDV—Hr(öDV—Hr(ö.......DW]DVz...DVz... >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BoÛèBoIÜmRNA-1273-P301 mRNA-1273-P301-US303-2187US3032187US303USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW:DVzHr©xDV–Hr'tÄDV–Hr'tÄDWHrØàDW:HrÿtÜDW:HrÿtÜ.DW]DVzDVþDVÿ.DVzDWDW. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BãmRNA-1273-P301 mRNA-1273-P301-US303-2204US3032204US303USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DVœDV}Hrq¬DVœHr/£ØDVœHr/£Ø.......DW]DV}DVÛ..DV}DVÛ.. Diabetes >=18 and <65 Years and at Risk A B@Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BYmRNA-1273-P301 mRNA-1273-P301-US303-2204US3032204US303USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DVœDV}Hrq¬DVœHr/£ØDVœHr/£Ø.......DW]DV}DVÛ..DV}DVÛ.. Diabetes >=18 and <65 Years and at Risk A B@Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BYBYmômRNA-1273-P301 mRNA-1273-P301-US303-2204US3032204US303USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DVœDV}Hrq¬DVœHr/£ØDVœHr/£Ø.......DW]DV}DVÛ..DV}DVÛ.. Diabetes >=18 and <65 Years and at Risk A B@Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BYmôBYÛèmRNA-1273-P301 mRNA-1273-P301-US303-2213US3032213US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW>DVHrÛLDVHr0~„DVHr0~„DW>Hsñ´DW>Hsñ´...DW]DVDW!DW".DVDW=DW>. Severe Obesity >=18 and <65 Years and at Risk A BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B\mRNA-1273-P301 mRNA-1273-P301-US303-2213US3032213US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW>DVHrÛLDVHr0~„DVHr0~„DW>Hsñ´DW>Hsñ´...DW]DVDW!DW".DVDW=DW>. Severe Obesity >=18 and <65 Years and at Risk A BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B\B\mômRNA-1273-P301 mRNA-1273-P301-US303-2213US3032213US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW>DVHrÛLDVHr0~„DVHr0~„DW>Hsñ´DW>Hsñ´...DW]DVDW!DW".DVDW=DW>. Severe Obesity >=18 and <65 Years and at Risk A BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B\môB\ÛèmRNA-1273-P301 mRNA-1273-P301-US303-2213US3032213US303USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW>DVHrÛLDVHr0~„DVHr0~„DW>Hsñ´DW>Hsñ´...DW]DVDW!DW".DVDW=DW>. Severe Obesity >=18 and <65 Years and at Risk A BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B\ÛèB\IÜmRNA-1273-P301 mRNA-1273-P301-US303-2225US3032225US303USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWODV‚Hr ðDV£Hr8q˜DV£Hr8q˜DW3HröAdDWOHs-¼DWOHs-¼.DW]DV‚DW2DW3.DV‚DW2DW3. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‹mRNA-1273-P301 mRNA-1273-P301-US303-2278US3032278US303USABJYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWZDVƒHr¨ôDV¥Hr;&¤DV¥Hr;&¤DW@Hs«¬DWZHs)ï(DWZHs)ï(.DW]DVƒDW?DW@.DVƒDW?DW@. Diabetes >=65 Years A0B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BŠmRNA-1273-P301 mRNA-1273-P301-US304-2026US3042026US304USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW1DVmHqñ‘8DVHr6ÀDVHr6ÀDWHrÉ€4DW1Hró½TDW1Hró½T.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BLmRNA-1273-P301 mRNA-1273-P301-US304-2026US3042026US304USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW1DVmHqñ‘8DVHr6ÀDVHr6ÀDWHrÉ€4DW1Hró½TDW1Hró½T.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BLBLmômRNA-1273-P301 mRNA-1273-P301-US304-2026US3042026US304USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW1DVmHqñ‘8DVHr6ÀDVHr6ÀDWHrÉ€4DW1Hró½TDW1Hró½T.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BLmôBLÛèmRNA-1273-P301 mRNA-1273-P301-US304-2026US3042026US304USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW1DVmHqñ‘8DVHr6ÀDVHr6ÀDWHrÉ€4DW1Hró½TDW1Hró½T.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BLÛèBLIÜmRNA-1273-P301 mRNA-1273-P301-US304-2028US3042028US304USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW3DVmHqñ˜DVŠHråDVŠHråDWHrÇFpDW3Hrö€DW3Hrö€.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B>mRNA-1273-P301 mRNA-1273-P301-US304-2028US3042028US304USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW3DVmHqñ˜DVŠHråDVŠHråDWHrÇFpDW3Hrö€DW3Hrö€.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B>B>mômRNA-1273-P301 mRNA-1273-P301-US304-2028US3042028US304USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW3DVmHqñ˜DVŠHråDVŠHråDWHrÇFpDW3Hrö€DW3Hrö€.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B>môB>ÛæmRNA-1273-P301 mRNA-1273-P301-US304-2028US3042028US304USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW3DVmHqñ˜DVŠHråDVŠHråDWHrÇFpDW3Hrö€DW3Hrö€.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B>ÛæB>IÚmRNA-1273-P301 mRNA-1273-P301-US304-2069US3042069US304USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW1DVsHqùŒDVHrh¬DVHrh¬DWHrÐsDW1Hróÿ¨DW1Hróÿ¨.DW]DVsDWDW.DVsDWDW. Diabetes >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBWmRNA-1273-P301 mRNA-1273-P301-US304-2069US3042069US304USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW1DVsHqùŒDVHrh¬DVHrh¬DWHrÐsDW1Hróÿ¨DW1Hróÿ¨.DW]DVsDWDW.DVsDWDW. Diabetes >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBWBWmômRNA-1273-P301 mRNA-1273-P301-US304-2072US3042072US304USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVtDVDVtHqú0DVHrgèDVHrgè.......DW]DVtDWDW.DVtDWDW. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BumRNA-1273-P301 mRNA-1273-P301-US304-2072US3042072US304USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVtDVDVtHqú0DVHrgèDVHrgè.......DW]DVtDWDW.DVtDWDW. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BuBumômRNA-1273-P301 mRNA-1273-P301-US304-2072US3042072US304USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVtDVDVtHqú0DVHrgèDVHrgè.......DW]DVtDWDW.DVtDWDW. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BumôBuÛèmRNA-1273-P301 mRNA-1273-P301-US304-2094US3042094US304USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVuDV‘DVuHqü LDV‘Hr ð¸DV‘Hr ð¸.......DW]DVuDWDW.DVuDWDW. Diabetes >=18 and <65 Years and at Risk A BÍMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B{mRNA-1273-P301 mRNA-1273-P301-US304-2095US3042095US304USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW7DVuHqüÜDV‘Hr!DV‘Hr!DWHrÒ 8DW7HrûõDW7Hrûõ.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BgmRNA-1273-P301 mRNA-1273-P301-US304-2100US3042100US304USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW1DVuHqü8hDV‘Hr!TDV‘Hr!TDWHrÎµTDW1HróßŒDW1HróßŒ.DW]DVuDWDW.DVuDWDW. Diabetes >=18 and <65 Years and at Risk A BÍNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BKmRNA-1273-P301 mRNA-1273-P301-US304-2115US3042115US304USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqý_|DV’Hr"=ˆDV’Hr"=ˆDW%Hrä!xDWFHs‘ÜDWFHs‘Ü.DW]DVvDWDW.DVvDW$DW%. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB[mRNA-1273-P301 mRNA-1273-P301-US304-2115US3042115US304USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqý_|DV’Hr"=ˆDV’Hr"=ˆDW%Hrä!xDWFHs‘ÜDWFHs‘Ü.DW]DVvDWDW.DVvDW$DW%. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB[B[mômRNA-1273-P301 mRNA-1273-P301-US304-2144US3042144US304USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW6DVzHrÕDV™Hr+¡HDV™Hr+¡HDWHrÕ²ŒDW6Hrú—(DW6Hrú—(.DW]DVzDWDW.DVzDWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BfmRNA-1273-P301 mRNA-1273-P301-US304-2152US3042152US304USAB=YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV{DVžDV{Hr¤DVžHr1¼ÌDVžHr1¼Ì.......DW]DV{DW..DV{DW..Chronic Lung Disease >=18 and <65 Years and at Risk A ByNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB’mRNA-1273-P301 mRNA-1273-P301-US304-2152US3042152US304USAB=YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV{DVžDV{Hr¤DVžHr1¼ÌDVžHr1¼Ì.......DW]DV{DW..DV{DW..Chronic Lung Disease >=18 and <65 Years and at Risk A ByNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB’B’mðmRNA-1273-P301 mRNA-1273-P301-US304-2153US3042153US304USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW1DV{Hr¥äDV—Hr(†HDV—Hr(†HDWHrÅôxDW1Hró”ŒDW1Hró”Œ.DW]DV{DW DW.DV{DW DW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BUmRNA-1273-P301 mRNA-1273-P301-US304-2153US3042153US304USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW1DV{Hr¥äDV—Hr(†HDV—Hr(†HDWHrÅôxDW1Hró”ŒDW1Hró”Œ.DW]DV{DW DW.DV{DW DW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BUBUmômRNA-1273-P301 mRNA-1273-P301-US304-2153US3042153US304USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW1DV{Hr¥äDV—Hr(†HDV—Hr(†HDWHrÅôxDW1Hró”ŒDW1Hró”Œ.DW]DV{DW DW.DV{DW DW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BUmôBUÛèmRNA-1273-P301 mRNA-1273-P301-US304-2185US3042185US304USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW1DV|HrcèDV˜Hr*KDV˜Hr*KDWHrÌeˆDW1HróýDW1Hróý.DW]DV|DWDW.DV|DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmmRNA-1273-P301 mRNA-1273-P301-US304-2185US3042185US304USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW1DV|HrcèDV˜Hr*KDV˜Hr*KDWHrÌeˆDW1HróýDW1Hróý.DW]DV|DWDW.DV|DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BmBmmômRNA-1273-P301 mRNA-1273-P301-US304-2185US3042185US304USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW1DV|HrcèDV˜Hr*KDV˜Hr*KDWHrÌeˆDW1HróýDW1Hróý.DW]DV|DWDW.DV|DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmmôBmÛèmRNA-1273-P301 mRNA-1273-P301-US304-2187US3042187US304USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DV˜DV|HriÄDV˜Hr*TDV˜Hr*T.......DW]DV|DW..DV|DW.. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B~Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BpmRNA-1273-P301 mRNA-1273-P301-US304-2187US3042187US304USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DV˜DV|HriÄDV˜Hr*TDV˜Hr*T.......DW]DV|DW..DV|DW.. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B~Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BpBpmômRNA-1273-P301 mRNA-1273-P301-US304-2187US3042187US304USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DV˜DV|HriÄDV˜Hr*TDV˜Hr*T.......DW]DV|DW..DV|DW.. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B~Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BpmôBpÛèmRNA-1273-P301 mRNA-1273-P301-US304-2187US3042187US304USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DV˜DV|HriÄDV˜Hr*TDV˜Hr*T.......DW]DV|DW..DV|DW.. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B~Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BpÛèBpIÜmRNA-1273-P301 mRNA-1273-P301-US304-2189US3042189US304USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWDDV|Hr{DV˜Hr*c´DV˜Hr*c´DW)HrésäDWDHs DWDHs .DW]DV|DW'DW(.DV|DW(DW). >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B"mRNA-1273-P301 mRNA-1273-P301-US304-2189US3042189US304USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWDDV|Hr{DV˜Hr*c´DV˜Hr*c´DW)HrésäDWDHs DWDHs .DW]DV|DW'DW(.DV|DW(DW). >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B"B"mômRNA-1273-P301 mRNA-1273-P301-US304-2189US3042189US304USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWDDV|Hr{DV˜Hr*c´DV˜Hr*c´DW)HrésäDWDHs DWDHs .DW]DV|DW'DW(.DV|DW(DW). >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B"môB"ÛæmRNA-1273-P301 mRNA-1273-P301-US304-2189US3042189US304USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWDDV|Hr{DV˜Hr*c´DV˜Hr*c´DW)HrésäDWDHs DWDHs .DW]DV|DW'DW(.DV|DW(DW). >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B"ÛæB"IÚmRNA-1273-P301 mRNA-1273-P301-US304-2226US3042226US304USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW1DVHræŒDVžHr1ùDVžHr1ùDWHrÅsÌDW1HróæXDW1HróæX.DW]DVDW DW.DVDW DW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BGmRNA-1273-P301 mRNA-1273-P301-US304-2226US3042226US304USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW1DVHræŒDVžHr1ùDVžHr1ùDWHrÅsÌDW1HróæXDW1HróæX.DW]DVDW DW.DVDW DW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BGBGmômRNA-1273-P301 mRNA-1273-P301-US304-2226US3042226US304USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW1DVHræŒDVžHr1ùDVžHr1ùDWHrÅsÌDW1HróæXDW1HróæX.DW]DVDW DW.DVDW DW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BGmôBGÛèmRNA-1273-P301 mRNA-1273-P301-US304-2226US3042226US304USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW1DVHræŒDVžHr1ùDVžHr1ùDWHrÅsÌDW1HróæXDW1HróæX.DW]DVDW DW.DVDW DW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BGÛèBGIÜmRNA-1273-P301 mRNA-1273-P301-US304-2232US3042232US304USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW(DVHrLDVHr0×XDVHr0×XDWHrÇ&TDW(Hrè ÈDW(Hrè È.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BMmRNA-1273-P301 mRNA-1273-P301-US304-2232US3042232US304USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW(DVHrLDVHr0×XDVHr0×XDWHrÇ&TDW(Hrè ÈDW(Hrè È.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BMBMmômRNA-1273-P301 mRNA-1273-P301-US304-2232US3042232US304USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW(DVHrLDVHr0×XDVHr0×XDWHrÇ&TDW(Hrè ÈDW(Hrè È.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BMmôBMÛèmRNA-1273-P301 mRNA-1273-P301-US304-2232US3042232US304USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW(DVHrLDVHr0×XDVHr0×XDWHrÇ&TDW(Hrè ÈDW(Hrè È.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BMÛèBMIÜmRNA-1273-P301 mRNA-1273-P301-US304-2238US3042238US304USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW6DV‚Hr ØDVžHr1óhDVžHr1óhDWHrÙltDW6Hrúb¨DW6Hrúb¨.DW]DV‚DWDW.DV‚DWDW. >=65 Years A0BÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBkmRNA-1273-P301 mRNA-1273-P301-US304-2238US3042238US304USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW6DV‚Hr ØDVžHr1óhDVžHr1óhDWHrÙltDW6Hrúb¨DW6Hrúb¨.DW]DV‚DWDW.DV‚DWDW. >=65 Years A0BÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBkBkmômRNA-1273-P301 mRNA-1273-P301-US304-2241US3042241US304USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‚DVžDV‚Hr /`DVžHr1õÀDVžHr1õÀ.......DW]DV‚...DV‚... >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B~mRNA-1273-P301 mRNA-1273-P301-US304-2241US3042241US304USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‚DVžDV‚Hr /`DVžHr1õÀDVžHr1õÀ.......DW]DV‚...DV‚... >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B~B~mômRNA-1273-P301 mRNA-1273-P301-US304-2241US3042241US304USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‚DVžDV‚Hr /`DVžHr1õÀDVžHr1õÀ.......DW]DV‚...DV‚... >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B~môB~ÛèmRNA-1273-P301 mRNA-1273-P301-US304-2248US3042248US304USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWSDV‚Hr X(DVžHr2>hDVžHr2>hDWSHs ë¼DWSHs ë¼...DW]DV‚DWRDWS.DV‚DWRDWS. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BŒmRNA-1273-P301 mRNA-1273-P301-US304-2248US3042248US304USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWSDV‚Hr X(DVžHr2>hDVžHr2>hDWSHs ë¼DWSHs ë¼...DW]DV‚DWRDWS.DV‚DWRDWS. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BŒBŒmðmRNA-1273-P301 mRNA-1273-P301-US304-2248US3042248US304USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWSDV‚Hr X(DVžHr2>hDVžHr2>hDWSHs ë¼DWSHs ë¼...DW]DV‚DWRDWS.DV‚DWRDWS. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BŒmðBŒÛèmRNA-1273-P301 mRNA-1273-P301-US304-2248US3042248US304USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWSDV‚Hr X(DVžHr2>hDVžHr2>hDWSHs ë¼DWSHs ë¼...DW]DV‚DWRDWS.DV‚DWRDWS. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BŒÛèBŒIØmRNA-1273-P301 mRNA-1273-P301-US304-2252US3042252US304USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW9DV‚Hr s”DVžHr2D€DVžHr2D€DWHrÕ±`DW9Hrþ‚ÀDW9Hrþ‚À.DW]DV‚DWDW.DV‚DWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B$mRNA-1273-P301 mRNA-1273-P301-US304-2252US3042252US304USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW9DV‚Hr s”DVžHr2D€DVžHr2D€DWHrÕ±`DW9Hrþ‚ÀDW9Hrþ‚À.DW]DV‚DWDW.DV‚DWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B$B$mômRNA-1273-P301 mRNA-1273-P301-US304-2252US3042252US304USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW9DV‚Hr s”DVžHr2D€DVžHr2D€DWHrÕ±`DW9Hrþ‚ÀDW9Hrþ‚À.DW]DV‚DWDW.DV‚DWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B$môB$ÛæmRNA-1273-P301 mRNA-1273-P301-US304-2253US3042253US304USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW9DV‚Hr tHDVžHr2DDVžHr2DDWHrÕ±$DW9Hrþ‚ÀDW9Hrþ‚À.DW]DV‚DWDW.DV‚DWDW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B$mRNA-1273-P301 mRNA-1273-P301-US304-2253US3042253US304USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW9DV‚Hr tHDVžHr2DDVžHr2DDWHrÕ±$DW9Hrþ‚ÀDW9Hrþ‚À.DW]DV‚DWDW.DV‚DWDW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B$B$mômRNA-1273-P301 mRNA-1273-P301-US304-2253US3042253US304USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW9DV‚Hr tHDVžHr2DDVžHr2DDWHrÕ±$DW9Hrþ‚ÀDW9Hrþ‚À.DW]DV‚DWDW.DV‚DWDW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B$môB$ÛæmRNA-1273-P301 mRNA-1273-P301-US304-2278US3042278US304USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW*DV„Hr„ÌDV Hr4`¼DV Hr4`¼DWHrÅœ”DW*HrêYXDW*HrêYX.DW]DV„DW DW.DV„DW DW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBnmRNA-1273-P301 mRNA-1273-P301-US304-2278US3042278US304USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW*DV„Hr„ÌDV Hr4`¼DV Hr4`¼DWHrÅœ”DW*HrêYXDW*HrêYX.DW]DV„DW DW.DV„DW DW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBnBnmômRNA-1273-P301 mRNA-1273-P301-US304-2316US3042316US304USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWLDV…HrFDV¦Hr<²DDV¦Hr<²DDW+Hrì4lDWLHsœ`DWLHsœ`.DW]DV…DW*DW+.DV…DW*DW+. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B‚mRNA-1273-P301 mRNA-1273-P301-US304-2316US3042316US304USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWLDV…HrFDV¦Hr<²DDV¦Hr<²DDW+Hrì4lDWLHsœ`DWLHsœ`.DW]DV…DW*DW+.DV…DW*DW+. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B‚B‚mðmRNA-1273-P301 mRNA-1273-P301-US304-2316US3042316US304USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWLDV…HrFDV¦Hr<²DDV¦Hr<²DDW+Hrì4lDWLHsœ`DWLHsœ`.DW]DV…DW*DW+.DV…DW*DW+. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B‚mðB‚ÛèmRNA-1273-P301 mRNA-1273-P301-US304-2316US3042316US304USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWLDV…HrFDV¦Hr<²DDV¦Hr<²DDW+Hrì4lDWLHsœ`DWLHsœ`.DW]DV…DW*DW+.DV…DW*DW+. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B‚ÛèB‚IØmRNA-1273-P301 mRNA-1273-P301-US306-2003US3062003US306USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWLDVoHqóëÌDV‹HrÐ¤DV‹HrÐ¤DW0HròTdDWLHs@DWLHs@.DW]DVoDW/DW0.DVoDW/DW0. >=65 Years A0BÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B¤mRNA-1273-P301 mRNA-1273-P301-US306-2003US3062003US306USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWLDVoHqóëÌDV‹HrÐ¤DV‹HrÐ¤DW0HròTdDWLHs@DWLHs@.DW]DVoDW/DW0.DVoDW/DW0. >=65 Years A0BÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B¤B¤mðmRNA-1273-P301 mRNA-1273-P301-US306-2003US3062003US306USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWLDVoHqóëÌDV‹HrÐ¤DV‹HrÐ¤DW0HròTdDWLHs@DWLHs@.DW]DVoDW/DW0.DVoDW/DW0. >=65 Years A0BÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B¤mðB¤ÛèmRNA-1273-P301 mRNA-1273-P301-US306-2089US3062089US306USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWADVtHqúq|DV’Hr"vôDV’Hr"vôDW"HràD¤DWAHs²àDWAHs²à.DW]DVtDW!DW".DVtDW!DW". >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B€mRNA-1273-P301 mRNA-1273-P301-US306-2135US3062135US306USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDWNDVuHqüO`DV’Hr"vôDV’Hr"vôDW/HrðõˆDWNHs×ŒDWNHs×Œ.DW]DVuDW.DW/.DVuDW.DW/. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B~mRNA-1273-P301 mRNA-1273-P301-US306-2135US3062135US306USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDWNDVuHqüO`DV’Hr"vôDV’Hr"vôDW/HrðõˆDWNHs×ŒDWNHs×Œ.DW]DVuDW.DW/.DVuDW.DW/. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B~B~mômRNA-1273-P301 mRNA-1273-P301-US306-2135US3062135US306USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDWNDVuHqüO`DV’Hr"vôDV’Hr"vôDW/HrðõˆDWNHs×ŒDWNHs×Œ.DW]DVuDW.DW/.DVuDW.DW/. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B~môB~ÛèmRNA-1273-P301 mRNA-1273-P301-US306-2165US3062165US306USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWSDVvHqý–ÌDV“Hr#{XDV“Hr#{XDW6Hrú2œDWSHs m,DWSHs m,.DW]DVvDW5DW6.DVvDW5DW6. >=18 and <65 Years and Not at RiskABËNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B–mRNA-1273-P301 mRNA-1273-P301-US306-2165US3062165US306USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWSDVvHqý–ÌDV“Hr#{XDV“Hr#{XDW6Hrú2œDWSHs m,DWSHs m,.DW]DVvDW5DW6.DVvDW5DW6. >=18 and <65 Years and Not at RiskABËNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B–B–mðmRNA-1273-P301 mRNA-1273-P301-US306-2165US3062165US306USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWSDVvHqý–ÌDV“Hr#{XDV“Hr#{XDW6Hrú2œDWSHs m,DWSHs m,.DW]DVvDW5DW6.DVvDW5DW6. >=18 and <65 Years and Not at RiskABËNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B–mðB–ÛèmRNA-1273-P301 mRNA-1273-P301-US306-2167US3062167US306USAB8YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYYYYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWADVwHqþtHDV–Hr'ApDV–Hr'ApDW"HrßßdDWAHs ¬DWAHs ¬.DW]DVwDW!DW".DVwDW!DW". Diabetes >=18 and <65 Years and at Risk A BÈNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B|mRNA-1273-P301 mRNA-1273-P301-US306-2167US3062167US306USAB8YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYYYYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWADVwHqþtHDV–Hr'ApDV–Hr'ApDW"HrßßdDWAHs ¬DWAHs ¬.DW]DVwDW!DW".DVwDW!DW". Diabetes >=18 and <65 Years and at Risk A BÈNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B|B|mômRNA-1273-P301 mRNA-1273-P301-US306-2167US3062167US306USAB8YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYYYYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWADVwHqþtHDV–Hr'ApDV–Hr'ApDW"HrßßdDWAHs ¬DWAHs ¬.DW]DVwDW!DW".DVwDW!DW". Diabetes >=18 and <65 Years and at Risk A BÈNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B|môB|ÛèmRNA-1273-P301 mRNA-1273-P301-US306-2210US3062210US306USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV—DVzHrrÜDV—Hr(—(DV—Hr(—(.......DW]DVzDW(DW).DVzDW(DW). >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB”mRNA-1273-P301 mRNA-1273-P301-US306-2210US3062210US306USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV—DVzHrrÜDV—Hr(—(DV—Hr(—(.......DW]DVzDW(DW).DVzDW(DW). >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB”B”mðmRNA-1273-P301 mRNA-1273-P301-US306-2312US3062312US306USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDW6DVšHr,™ôDVµHrPlDVµHrPlDW6HrúA$DW6HrúA$...DW]DVšDW5DW6.DVšDW5DW6. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmRNA-1273-P301 mRNA-1273-P301-US308-2021US3082021US308USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW9DV{HrœDV˜Hr*<DV˜Hr*<DWHrÙ’lDW9HrþwDDW9HrþwD.DW]DV{DWDW.DV{DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BymRNA-1273-P301 mRNA-1273-P301-US308-2021US3082021US308USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW9DV{HrœDV˜Hr*<DV˜Hr*<DWHrÙ’lDW9HrþwDDW9HrþwD.DW]DV{DWDW.DV{DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score ByBymômRNA-1273-P301 mRNA-1273-P301-US308-2021US3082021US308USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW9DV{HrœDV˜Hr*<DV˜Hr*<DWHrÙ’lDW9HrþwDDW9HrþwD.DW]DV{DWDW.DV{DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BymôByÛèmRNA-1273-P301 mRNA-1273-P301-US308-2021US3082021US308USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW9DV{HrœDV˜Hr*<DV˜Hr*<DWHrÙ’lDW9HrþwDDW9HrþwD.DW]DV{DWDW.DV{DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score ByÛèByIÜmRNA-1273-P301 mRNA-1273-P301-US308-2049US3082049US308USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWNDVHr¼ DVHr0¨ðDVHr0¨ðDW2HrõÌDWNHs\DWNHs\.DW]DVDW1DW2.DVDW1DW2. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BŽmRNA-1273-P301 mRNA-1273-P301-US308-2049US3082049US308USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWNDVHr¼ DVHr0¨ðDVHr0¨ðDW2HrõÌDWNHs\DWNHs\.DW]DVDW1DW2.DVDW1DW2. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BŽBŽmðmRNA-1273-P301 mRNA-1273-P301-US308-2049US3082049US308USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWNDVHr¼ DVHr0¨ðDVHr0¨ðDW2HrõÌDWNHs\DWNHs\.DW]DVDW1DW2.DVDW1DW2. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BŽmðBŽÛèmRNA-1273-P301 mRNA-1273-P301-US308-2100US3082100US308USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW7DVˆHrÖüDV¦Hr<\|DV¦Hr<\|DWHrÖš”DW7Hrû€ DW7Hrû€ .DW]DVˆDW DW.DVˆDWDW. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBwmRNA-1273-P301 mRNA-1273-P301-US308-2100US3082100US308USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW7DVˆHrÖüDV¦Hr<\|DV¦Hr<\|DWHrÖš”DW7Hrû€ DW7Hrû€ .DW]DVˆDW DW.DVˆDWDW. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBwBwmômRNA-1273-P301 mRNA-1273-P301-US308-2166US3082166US308USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWDDVŸHr32(DV»HrXÀDV»HrXÀDW+HrëÎxDWDHs·DWDHs·.DW]DVŸDW*DW+.DVŸDW*DW+. >=65 Years A0B£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBsmRNA-1273-P301 mRNA-1273-P301-US308-2166US3082166US308USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWDDVŸHr32(DV»HrXÀDV»HrXÀDW+HrëÎxDWDHs·DWDHs·.DW]DVŸDW*DW+.DVŸDW*DW+. >=65 Years A0B£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBsBsmômRNA-1273-P301 mRNA-1273-P301-US309-2019US3092019US309USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW@DVtHqú…,DVHr\lDVHr\lDW$HrâtDW@Hs^ÌDW@Hs^Ì.DW]DVtDW#DW$.DVtDW#DW$.Chronic Lung Disease >=18 and <65 Years and at Risk A BÎMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BhmRNA-1273-P301 mRNA-1273-P301-US309-2026US3092026US309USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWEDVtHqúÉ`DVHr·\DVHr·\DWHrÖ½DWEHsÌDWEHsÌ.DW]DVtDWDW.DVtDWDW. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BlmRNA-1273-P301 mRNA-1273-P301-US309-2130US3092130US309USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWNDV{Hr¬DVžHr1ÍèDVžHr1ÍèDW1HróœHDWNHsØ@DWNHsØ@.DW]DV{DW0DW1.DV{DW0DW1. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmRNA-1273-P301 mRNA-1273-P301-US309-2130US3092130US309USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWNDV{Hr¬DVžHr1ÍèDVžHr1ÍèDW1HróœHDWNHsØ@DWNHsØ@.DW]DV{DW0DW1.DV{DW0DW1. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBmðmRNA-1273-P301 mRNA-1273-P301-US309-2134US3092134US309USAB:YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWFDV~Hr¥hDV¥Hr;C´DV¥Hr;C´DWFHs8DWFHs8...DW]DV~DWEDWF.DV~DWEDWF.Chronic Lung DiseaseSignificant Cardiac Disease >=18 and <65 Years and at Risk A B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmRNA-1273-P301 mRNA-1273-P301-US309-2135US3092135US309USAB@YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DW@DV~Hr$DVšHr,†DVšHr,†DWHrÚŠ(DW@HsjHDW@HsjH.DW]DV~DWDW.DV~DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÄMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BymRNA-1273-P301 mRNA-1273-P301-US309-2162US3092162US309USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‚DV£DV‚Hr =¬DV£Hr8iÜDV£Hr8iÜ.......DW]DV‚DWDDWEDWEDV‚DWDDWEDWE >=18 and <65 Years and Not at RiskAB£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BamRNA-1273-P301 mRNA-1273-P301-US309-2163US3092163US309USAB"YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW?DV‚Hr A¨DVŸHr3!DVŸHr3!DWHr×ø¼DW?Hs˜DW?Hs˜.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BimRNA-1273-P301 mRNA-1273-P301-US309-2246US3092246US309USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW,DVŠHr· DV«HrC[ÐDV«HrC[ÐDW HrÄŽXDW,Hrí ðDW,Hrí ð.DW]DVŠDWDW .DVŠDWDW . >=18 and <65 Years and Not at RiskAB³Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B%mRNA-1273-P301 mRNA-1273-P301-US309-2272US3092272US309USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŒDWGDVŒHrXDV¦Hr<£øDV¦Hr<£øDWGHs£œDWGHs£œ...DW]DVŒDWFDWG.DVŒDWFDWG. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‚mRNA-1273-P301 mRNA-1273-P301-US309-2272US3092272US309USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŒDWGDVŒHrXDV¦Hr<£øDV¦Hr<£øDWGHs£œDWGHs£œ...DW]DVŒDWFDWG.DVŒDWFDWG. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‚B‚mðmRNA-1273-P301 mRNA-1273-P301-US309-2272US3092272US309USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŒDWGDVŒHrXDV¦Hr<£øDV¦Hr<£øDWGHs£œDWGHs£œ...DW]DVŒDWFDWG.DVŒDWFDWG. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‚mðB‚ÛèmRNA-1273-P301 mRNA-1273-P301-US310-2271US3102271US310USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW]DV‰Hr–hDV£Hr8Ð„DV£Hr8Ð„DW;HsËDW]Hs-êìDW]Hs-êì.DW]DV‰DW:DW;.DV‰DW:DW;. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BÔmRNA-1273-P301 mRNA-1273-P301-US310-2276US3102276US310USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWIDVŠHr†hDV¥Hr; DV¥Hr; DWIHs‹DWIHs‹...DW]DVŠDWHDWI.DVŠDWHDWI. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B}mRNA-1273-P301 mRNA-1273-P301-US310-2361US3102361US310USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWPDVœHr/ŸdDVµHrP‰,DVµHrP‰,DW4Hr÷ŒTDWPHs{@DWPHs{@.DW]DVœDW3DW4.DVœDW3DW4. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BHmRNA-1273-P301 mRNA-1273-P301-US310-2361US3102361US310USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWPDVœHr/ŸdDVµHrP‰,DVµHrP‰,DW4Hr÷ŒTDWPHs{@DWPHs{@.DW]DVœDW3DW4.DVœDW3DW4. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BHBHmômRNA-1273-P301 mRNA-1273-P301-US310-2361US3102361US310USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWPDVœHr/ŸdDVµHrP‰,DVµHrP‰,DW4Hr÷ŒTDWPHs{@DWPHs{@.DW]DVœDW3DW4.DVœDW3DW4. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BHmôBHÛèmRNA-1273-P301 mRNA-1273-P301-US310-2381US3102381US310USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DWPDV Hr4ŒÌDVºHrVÈPDVºHrVÈPDW4Hr÷á,DWPHs|äDWPHs|ä.DW]DV DW3DW4.DV DW3DW4. Severe Obesity >=18 and <65 Years and at Risk A B¤Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBgmRNA-1273-P301 mRNA-1273-P301-US310-2381US3102381US310USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DWPDV Hr4ŒÌDVºHrVÈPDVºHrVÈPDW4Hr÷á,DWPHs|äDWPHs|ä.DW]DV DW3DW4.DV DW3DW4. Severe Obesity >=18 and <65 Years and at Risk A B¤Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBgBgmômRNA-1273-P301 mRNA-1273-P301-US311-2049US3112049US311USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWLDVoHqô`DV‹HrÔDV‹HrÔDW(Hrç¾ŒDWLHss DWLHss .DW]DVoDW DW.DVoDW'DW(. >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BamRNA-1273-P301 mRNA-1273-P301-US311-2076US3112076US311USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWHDVsHqùDV’Hr"$DV’Hr"$DW+Hrë®˜DWHHs 4DWHHs 4.DW]DVsDW*DW+.DVsDW*DW+. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B‘mRNA-1273-P301 mRNA-1273-P301-US311-2076US3112076US311USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWHDVsHqùDV’Hr"$DV’Hr"$DW+Hrë®˜DWHHs 4DWHHs 4.DW]DVsDW*DW+.DVsDW*DW+. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B‘B‘mðmRNA-1273-P301 mRNA-1273-P301-US311-2076US3112076US311USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWHDVsHqùDV’Hr"$DV’Hr"$DW+Hrë®˜DWHHs 4DWHHs 4.DW]DVsDW*DW+.DVsDW*DW+. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B‘mðB‘ÛèmRNA-1273-P301 mRNA-1273-P301-US311-2076US3112076US311USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWHDVsHqùDV’Hr"$DV’Hr"$DW+Hrë®˜DWHHs 4DWHHs 4.DW]DVsDW*DW+.DVsDW*DW+. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B‘ÛèB‘IØmRNA-1273-P301 mRNA-1273-P301-US311-2077US3112077US311USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWHDVsHqù °DV’Hr"ŒDV’Hr"ŒDW+Hrë¯DWHHs ¬DWHHs ¬.DW]DVsDW*DW+.DVsDW*DW+. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US311-2077US3112077US311USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWHDVsHqù °DV’Hr"ŒDV’Hr"ŒDW+Hrë¯DWHHs ¬DWHHs ¬.DW]DVsDW*DW+.DVsDW*DW+. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmðmRNA-1273-P301 mRNA-1273-P301-US311-2077US3112077US311USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWHDVsHqù °DV’Hr"ŒDV’Hr"ŒDW+Hrë¯DWHHs ¬DWHHs ¬.DW]DVsDW*DW+.DVsDW*DW+. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US311-2149US3112149US311USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWSDVvHqý9DV—Hr(ðtDV—Hr(ðtDW7HrûÑìDWSHs ¶ˆDWSHs ¶ˆ.DW]DVvDW6DW7.DVvDW6DW7. Severe ObesityDiabetes >=18 and <65 Years and at Risk A BÇMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B—mRNA-1273-P301 mRNA-1273-P301-US311-2211US3112211US311USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWHDV{Hrâ DV—Hr(õœDV—Hr(õœDWHHs°DWHHs°...DW]DV{DW DW.DV{DWGDWH. >=18 and <65 Years and Not at RiskABÇMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‹mRNA-1273-P301 mRNA-1273-P301-US311-2211US3112211US311USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWHDV{Hrâ DV—Hr(õœDV—Hr(õœDWHHs°DWHHs°...DW]DV{DW DW.DV{DWGDWH. >=18 and <65 Years and Not at RiskABÇMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‹B‹mðmRNA-1273-P301 mRNA-1273-P301-US311-2211US3112211US311USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWHDV{Hrâ DV—Hr(õœDV—Hr(õœDWHHs°DWHHs°...DW]DV{DW DW.DV{DWGDWH. >=18 and <65 Years and Not at RiskABÇMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‹mðB‹ÛèmRNA-1273-P301 mRNA-1273-P301-US311-2219US3112219US311USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWVDV{HrDV—Hr(”DV—Hr(”DW6HrúÔDWVHs$kDWVHs$k.DW]DV{DW DW.DV{DW5DW6. >=18 and <65 Years and Not at RiskABÇMinority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB~mRNA-1273-P301 mRNA-1273-P301-US311-2219US3112219US311USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWVDV{HrDV—Hr(”DV—Hr(”DW6HrúÔDWVHs$kDWVHs$k.DW]DV{DW DW.DV{DW5DW6. >=18 and <65 Years and Not at RiskABÇMinority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB~B~mômRNA-1273-P301 mRNA-1273-P301-US311-2366US3112366US311USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW@DV‡Hrã´DV£Hr8¿hDV£Hr8¿hDW$Hrâv¬DW@Hs¾0DW@Hs¾0.DW]DV‡DW#DW$.DV‡DW#DW$. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B€mRNA-1273-P301 mRNA-1273-P301-US311-2366US3112366US311USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW@DV‡Hrã´DV£Hr8¿hDV£Hr8¿hDW$Hrâv¬DW@Hs¾0DW@Hs¾0.DW]DV‡DW#DW$.DV‡DW#DW$. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B€B€mðmRNA-1273-P301 mRNA-1273-P301-US311-2366US3112366US311USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW@DV‡Hrã´DV£Hr8¿hDV£Hr8¿hDW$Hrâv¬DW@Hs¾0DW@Hs¾0.DW]DV‡DW#DW$.DV‡DW#DW$. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B€mðB€ÛèmRNA-1273-P301 mRNA-1273-P301-US311-2475US3112475US311USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWTDVHr0Î4DV»HrXZøDV»HrXZøDW7HrûíÐDWTHs"$ÜDWTHs"$Ü.DW]DVDW DW.DVDW6DW7. >=18 and <65 Years and Not at RiskAB£Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBVmRNA-1273-P301 mRNA-1273-P301-US311-2475US3112475US311USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWTDVHr0Î4DV»HrXZøDV»HrXZøDW7HrûíÐDWTHs"$ÜDWTHs"$Ü.DW]DVDW DW.DVDW6DW7. >=18 and <65 Years and Not at RiskAB£Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBVBVmômRNA-1273-P301 mRNA-1273-P301-US312-2032US3122032US312USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW=DVkHqîï DVˆHr"°DVˆHr"°DWHrÌtˆDW=HsÅ´DW=HsÅ´.DW]DVkDWDW.DVkDWDW. >=65 Years A0BÖNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BpmRNA-1273-P301 mRNA-1273-P301-US312-2032US3122032US312USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW=DVkHqîï DVˆHr"°DVˆHr"°DWHrÌtˆDW=HsÅ´DW=HsÅ´.DW]DVkDWDW.DVkDWDW. >=65 Years A0BÖNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BpBpmômRNA-1273-P301 mRNA-1273-P301-US312-2032US3122032US312USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW=DVkHqîï DVˆHr"°DVˆHr"°DWHrÌtˆDW=HsÅ´DW=HsÅ´.DW]DVkDWDW.DVkDWDW. >=65 Years A0BÖNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BpmôBpÛèmRNA-1273-P301 mRNA-1273-P301-US312-2055US3122055US312USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVlDVˆDVlHqïìDVˆHróXDVˆHróX.......DW]DVlDVúDVûDVûDVlDVúDVûDVû >=18 and <65 Years and Not at RiskABtNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BxmRNA-1273-P301 mRNA-1273-P301-US312-2055US3122055US312USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVlDVˆDVlHqïìDVˆHróXDVˆHróX.......DW]DVlDVúDVûDVûDVlDVúDVûDVû >=18 and <65 Years and Not at RiskABtNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BxBxmômRNA-1273-P301 mRNA-1273-P301-US312-2055US3122055US312USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVlDVˆDVlHqïìDVˆHróXDVˆHróX.......DW]DVlDVúDVûDVûDVlDVúDVûDVû >=18 and <65 Years and Not at RiskABtNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BxmôBxÛèmRNA-1273-P301 mRNA-1273-P301-US312-2055US3122055US312USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVlDVˆDVlHqïìDVˆHróXDVˆHróX.......DW]DVlDVúDVûDVûDVlDVúDVûDVû >=18 and <65 Years and Not at RiskABtNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BxÛèBxIÜmRNA-1273-P301 mRNA-1273-P301-US312-2059US3122059US312USAB2YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVlDW6DVlHqïóPDVŠHr›¼DVŠHr›¼DWHrÕªÐDW6Hrú:”DW6Hrú:”.DW]DVlDWDW.DVlDWDW. Diabetes >=18 and <65 Years and at Risk A BÔMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBfmRNA-1273-P301 mRNA-1273-P301-US312-2059US3122059US312USAB2YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVlDW6DVlHqïóPDVŠHr›¼DVŠHr›¼DWHrÕªÐDW6Hrú:”DW6Hrú:”.DW]DVlDWDW.DVlDWDW. Diabetes >=18 and <65 Years and at Risk A BÔMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBfBfmômRNA-1273-P301 mRNA-1273-P301-US313-2027US3132027US313USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW3DV‰Hr1(DV¤Hr9ðÌDV¤Hr9ðÌDWHrÑWÜDW3Hrö5¬DW3Hrö5¬.DW]DV‰DW DW.DV‰DWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BZmRNA-1273-P301 mRNA-1273-P301-US313-2039US3132039US313USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‘DVDV‘Hr æhDVHrE×èDVHrE×è......DVûDVûDV‘DVþDVÿDWDV‘DVþDVÿDW >=18 and <65 Years and Not at RiskABUNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B\mRNA-1273-P301 mRNA-1273-P301-US313-2039US3132039US313USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‘DVDV‘Hr æhDVHrE×èDVHrE×è......DVûDVûDV‘DVþDVÿDWDV‘DVþDVÿDW >=18 and <65 Years and Not at RiskABUNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B\B\mômRNA-1273-P301 mRNA-1273-P301-US313-2039US3132039US313USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‘DVDV‘Hr æhDVHrE×èDVHrE×è......DVûDVûDV‘DVþDVÿDWDV‘DVþDVÿDW >=18 and <65 Years and Not at RiskABUNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B\môB\ÛèmRNA-1273-P301 mRNA-1273-P301-US313-2039US3132039US313USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‘DVDV‘Hr æhDVHrE×èDVHrE×è......DVûDVûDV‘DVþDVÿDWDV‘DVþDVÿDW >=18 and <65 Years and Not at RiskABUNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B\ÛèB\IÜmRNA-1273-P301 mRNA-1273-P301-US313-2043US3132043US313USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV˜DVºDV˜Hr*E<DVºHrV¤°DVºHrV¤°......DW7DW7DV˜DW9..DV˜DW9.. >=18 and <65 Years and Not at RiskAB€Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BamRNA-1273-P301 mRNA-1273-P301-US313-2043US3132043US313USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV˜DVºDV˜Hr*E<DVºHrV¤°DVºHrV¤°......DW7DW7DV˜DW9..DV˜DW9.. >=18 and <65 Years and Not at RiskAB€Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BaBamômRNA-1273-P301 mRNA-1273-P301-US313-2043US3132043US313USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV˜DVºDV˜Hr*E<DVºHrV¤°DVºHrV¤°......DW7DW7DV˜DW9..DV˜DW9.. >=18 and <65 Years and Not at RiskAB€Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BamôBaÛèmRNA-1273-P301 mRNA-1273-P301-US313-2043US3132043US313USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV˜DVºDV˜Hr*E<DVºHrV¤°DVºHrV¤°......DW7DW7DV˜DW9..DV˜DW9.. >=18 and <65 Years and Not at RiskAB€Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BaÛèBaIÜmRNA-1273-P301 mRNA-1273-P301-US313-2078US3132078US313USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DW8DV£Hr80DVÁHr` DVÁHr` DWHr×èTDW8Hrý0DW8Hrý0.DW]DV£DWDW.DV£DWDW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BVmRNA-1273-P301 mRNA-1273-P301-US313-2078US3132078US313USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DW8DV£Hr80DVÁHr` DVÁHr` DWHr×èTDW8Hrý0DW8Hrý0.DW]DV£DWDW.DV£DWDW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BVBVmômRNA-1273-P301 mRNA-1273-P301-US313-2078US3132078US313USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DW8DV£Hr80DVÁHr` DVÁHr` DWHr×èTDW8Hrý0DW8Hrý0.DW]DV£DWDW.DV£DWDW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BVmôBVÛèmRNA-1273-P301 mRNA-1273-P301-US313-2084US3132084US313USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DW\DV¥Hr;ÜDV¿Hr]V4DV¿Hr]V4DW?HsTDW\Hs,;èDW\Hs,;è.DW]DV¥DW8DW9.DV¥DW>DW?. >=18 and <65 Years and Not at RiskABŸMinority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BqmRNA-1273-P301 mRNA-1273-P301-US313-2084US3132084US313USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DW\DV¥Hr;ÜDV¿Hr]V4DV¿Hr]V4DW?HsTDW\Hs,;èDW\Hs,;è.DW]DV¥DW8DW9.DV¥DW>DW?. >=18 and <65 Years and Not at RiskABŸMinority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BqBqmômRNA-1273-P301 mRNA-1273-P301-US313-2084US3132084US313USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DW\DV¥Hr;ÜDV¿Hr]V4DV¿Hr]V4DW?HsTDW\Hs,;èDW\Hs,;è.DW]DV¥DW8DW9.DV¥DW>DW?. >=18 and <65 Years and Not at RiskABŸMinority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BqmôBqÛèmRNA-1273-P301 mRNA-1273-P301-US313-2084US3132084US313USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DW\DV¥Hr;ÜDV¿Hr]V4DV¿Hr]V4DW?HsTDW\Hs,;èDW\Hs,;è.DW]DV¥DW8DW9.DV¥DW>DW?. >=18 and <65 Years and Not at RiskABŸMinority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BqÛèBqIÜmRNA-1273-P301 mRNA-1273-P301-US313-2110US3132110US313USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DWRDV´HrO,lDVÐHrsÈ`DVÐHrsÈ`DW/Hrðï4DWRHs DWRHs .DW]DV´DW.DW/.DV´DW.DW/. Diabetes >=18 and <65 Years and at Risk A BŽMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBYmRNA-1273-P301 mRNA-1273-P301-US313-2110US3132110US313USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DWRDV´HrO,lDVÐHrsÈ`DVÐHrsÈ`DW/Hrðï4DWRHs DWRHs .DW]DV´DW.DW/.DV´DW.DW/. Diabetes >=18 and <65 Years and at Risk A BŽMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBYBYmômRNA-1273-P301 mRNA-1273-P301-US314-2034US3142034US314USABJYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWEDVoHqôDVŠHrÀÄDVŠHrÀÄDWEHsˆDWEHsˆ...DW]DVoDWDW.DVoDWDDWE. >=65 Years A0BÔNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BˆmRNA-1273-P301 mRNA-1273-P301-US314-2043US3142043US314USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVpDWLDVpHqõK\DVHrjÈDVHrjÈDWLHspDWLHsp...DW]DVpDWDW.DVpDWKDWL. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB{mRNA-1273-P301 mRNA-1273-P301-US314-2043US3142043US314USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVpDWLDVpHqõK\DVHrjÈDVHrjÈDWLHspDWLHsp...DW]DVpDWDW.DVpDWKDWL. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB{B{mômRNA-1273-P301 mRNA-1273-P301-US314-2056US3142056US314USAB:YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYNYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW>DVrHq÷ÜDVHrUìDVHrUìDW>Hs¾`DW>Hs¾`...DW]DVrDW=DW>.DVrDW=DW>.Chronic Lung Disease >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBŒmRNA-1273-P301 mRNA-1273-P301-US314-2056US3142056US314USAB:YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYNYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW>DVrHq÷ÜDVHrUìDVHrUìDW>Hs¾`DW>Hs¾`...DW]DVrDW=DW>.DVrDW=DW>.Chronic Lung Disease >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBŒBŒmðmRNA-1273-P301 mRNA-1273-P301-US314-2100US3142100US314USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWLDVsHqù…xDV‘Hr ÕDV‘Hr ÕDW2Hrõ8PDWLHs€DWLHs€.DW]DVsDW1DW2.DVsDW1DW2. >=65 Years A0BÍNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B2mRNA-1273-P301 mRNA-1273-P301-US314-2100US3142100US314USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWLDVsHqù…xDV‘Hr ÕDV‘Hr ÕDW2Hrõ8PDWLHs€DWLHs€.DW]DVsDW1DW2.DVsDW1DW2. >=65 Years A0BÍNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B2B2mômRNA-1273-P301 mRNA-1273-P301-US314-2100US3142100US314USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWLDVsHqù…xDV‘Hr ÕDV‘Hr ÕDW2Hrõ8PDWLHs€DWLHs€.DW]DVsDW1DW2.DVsDW1DW2. >=65 Years A0BÍNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B2môB2ÛæmRNA-1273-P301 mRNA-1273-P301-US314-2228US3142228US314USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW\DV€Hr ¶ÌDVžHr29DVžHr29DWFHsµ@DW\Hs,oxDW\Hs,ox.DW]DV€DWEDWF.DV€DWEDWF. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmRNA-1273-P301 mRNA-1273-P301-US314-2232US3142232US314USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWYDVHr¦TDVžHr1ÕàDVžHr1ÕàDW>HsÌèDWYHs(‚DWYHs(‚.DW]DVDW=DW>.DVDW=DW>. >=18 and <65 Years and Not at RiskABÀMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B_mRNA-1273-P301 mRNA-1273-P301-US314-2232US3142232US314USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWYDVHr¦TDVžHr1ÕàDVžHr1ÕàDW>HsÌèDWYHs(‚DWYHs(‚.DW]DVDW=DW>.DVDW=DW>. >=18 and <65 Years and Not at RiskABÀMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B_B_mômRNA-1273-P301 mRNA-1273-P301-US314-2232US3142232US314USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWYDVHr¦TDVžHr1ÕàDVžHr1ÕàDW>HsÌèDWYHs(‚DWYHs(‚.DW]DVDW=DW>.DVDW=DW>. >=18 and <65 Years and Not at RiskABÀMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B_môB_ÛèmRNA-1273-P301 mRNA-1273-P301-US314-2232US3142232US314USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWYDVHr¦TDVžHr1ÕàDVžHr1ÕàDW>HsÌèDWYHs(‚DWYHs(‚.DW]DVDW=DW>.DVDW=DW>. >=18 and <65 Years and Not at RiskABÀMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B_ÛèB_IÜmRNA-1273-P301 mRNA-1273-P301-US314-2252US3142252US314USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWNDVˆHr=àDV¤Hr:øDV¤Hr:øDWNHsõPDWNHsõP...DW]DVˆDWMDWN.DVˆDWMDWN. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BNmRNA-1273-P301 mRNA-1273-P301-US314-2252US3142252US314USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWNDVˆHr=àDV¤Hr:øDV¤Hr:øDWNHsõPDWNHsõP...DW]DVˆDWMDWN.DVˆDWMDWN. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BNBNmômRNA-1273-P301 mRNA-1273-P301-US314-2252US3142252US314USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWNDVˆHr=àDV¤Hr:øDV¤Hr:øDWNHsõPDWNHsõP...DW]DVˆDWMDWN.DVˆDWMDWN. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BNmôBNÛèmRNA-1273-P301 mRNA-1273-P301-US314-2252US3142252US314USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWNDVˆHr=àDV¤Hr:øDV¤Hr:øDWNHsõPDWNHsõP...DW]DVˆDWMDWN.DVˆDWMDWN. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BNÛèBNIÜmRNA-1273-P301 mRNA-1273-P301-US314-2255US3142255US314USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWDDV‰Hr80DV¥Hr; „DV¥Hr; „DWDHsü8DWDHsü8...DW]DV‰DW>DW?.DV‰DWCDWD. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BRmRNA-1273-P301 mRNA-1273-P301-US314-2255US3142255US314USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWDDV‰Hr80DV¥Hr; „DV¥Hr; „DWDHsü8DWDHsü8...DW]DV‰DW>DW?.DV‰DWCDWD. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BRBRmômRNA-1273-P301 mRNA-1273-P301-US314-2255US3142255US314USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWDDV‰Hr80DV¥Hr; „DV¥Hr; „DWDHsü8DWDHsü8...DW]DV‰DW>DW?.DV‰DWCDWD. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BRmôBRÛèmRNA-1273-P301 mRNA-1273-P301-US314-2255US3142255US314USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWDDV‰Hr80DV¥Hr; „DV¥Hr; „DWDHsü8DWDHsü8...DW]DV‰DW>DW?.DV‰DWCDWD. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BRÛèBRIÜmRNA-1273-P301 mRNA-1273-P301-US315-2034US3152034US315USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW!DVmHqñ…¼DV‰HräDV‰HräDWHr¼n€DW!HrÞÁ°DW!HrÞÁ°.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÕNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BamRNA-1273-P301 mRNA-1273-P301-US315-2034US3152034US315USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW!DVmHqñ…¼DV‰HräDV‰HräDWHr¼n€DW!HrÞÁ°DW!HrÞÁ°.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÕNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BaBamômRNA-1273-P301 mRNA-1273-P301-US315-2034US3152034US315USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW!DVmHqñ…¼DV‰HräDV‰HräDWHr¼n€DW!HrÞÁ°DW!HrÞÁ°.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÕNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BamôBaÛèmRNA-1273-P301 mRNA-1273-P301-US315-2034US3152034US315USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW!DVmHqñ…¼DV‰HräDV‰HräDWHr¼n€DW!HrÞÁ°DW!HrÞÁ°.DW]DVmDWDW.DVmDWDW. >=18 and <65 Years and Not at RiskABÕNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BaÛèBaIÜmRNA-1273-P301 mRNA-1273-P301-US315-2061US3152061US315USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWADVoHqóù DVHr1ÔDVHr1ÔDWHr×ûŒDWAHsÇDDWAHsÇD.DW]DVoDWDW.DVoDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B_mRNA-1273-P301 mRNA-1273-P301-US315-2088US3152088US315USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWNDVtHqúz(DV‘Hr ®ÜDV‘Hr ®ÜDW2HrôçtDWNHsÉDWNHsÉ.DW]DVtDW1DW2.DVtDW1DW2. >=18 and <65 Years and Not at RiskABÍMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBvmRNA-1273-P301 mRNA-1273-P301-US315-2088US3152088US315USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWNDVtHqúz(DV‘Hr ®ÜDV‘Hr ®ÜDW2HrôçtDWNHsÉDWNHsÉ.DW]DVtDW1DW2.DVtDW1DW2. >=18 and <65 Years and Not at RiskABÍMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBvBvmômRNA-1273-P301 mRNA-1273-P301-US315-2169US3152169US315USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWVDV|HrUœDV™Hr+„°DV™Hr+„°DW6Hrú DWVHs$ŠìDWVHs$Šì.DW]DV|DW+DW,.DV|DW5DW6. Diabetes >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‘mRNA-1273-P301 mRNA-1273-P301-US315-2169US3152169US315USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWVDV|HrUœDV™Hr+„°DV™Hr+„°DW6Hrú DWVHs$ŠìDWVHs$Šì.DW]DV|DW+DW,.DV|DW5DW6. Diabetes >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‘B‘mðmRNA-1273-P301 mRNA-1273-P301-US315-2169US3152169US315USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWVDV|HrUœDV™Hr+„°DV™Hr+„°DW6Hrú DWVHs$ŠìDWVHs$Šì.DW]DV|DW+DW,.DV|DW5DW6. Diabetes >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‘mðB‘ÛèmRNA-1273-P301 mRNA-1273-P301-US315-2189US3152189US315USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWMDV}HrOìDVHr0w|DVHr0w|DW2Hrõ5DDWMHs’´DWMHs’´.DW]DV}DW1DW2.DV}DW1DW2. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BlmRNA-1273-P301 mRNA-1273-P301-US315-2211US3152211US315USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW0DV}HrŸ`DVžHr2DVžHr2DWHrÎüXDW0Hrò—äDW0Hrò—ä.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB_mRNA-1273-P301 mRNA-1273-P301-US315-2211US3152211US315USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW0DV}HrŸ`DVžHr2DVžHr2DWHrÎüXDW0Hrò—äDW0Hrò—ä.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB_B_mômRNA-1273-P301 mRNA-1273-P301-US315-2455US3152455US315USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DWNDV´HrNÛDV×Hr}[<DV×Hr}[<DW,HríxDWNHs5LDWNHs5L.DW]DV´DW+DW,.DV´DW+DW,. >=18 and <65 Years and Not at RiskAB‡Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BTmRNA-1273-P301 mRNA-1273-P301-US315-2486US3152486US315USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVºDWLDVºHrW0DV×Hr}pDV×Hr}pDW/Hrñ:4DWLHs;”DWLHs;”.DW]DVºDW.DW/.DVºDW.DW/. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B‡Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBNmRNA-1273-P301 mRNA-1273-P301-US315-2486US3152486US315USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVºDWLDVºHrW0DV×Hr}pDV×Hr}pDW/Hrñ:4DWLHs;”DWLHs;”.DW]DVºDW.DW/.DVºDW.DW/. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B‡Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBNBNmômRNA-1273-P301 mRNA-1273-P301-US315-2499US3152499US315USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DW@DV»HrXv(DVØHr~©8DVØHr~©8DW"HrßîdDW@HsÀDW@HsÀ.DW]DV»DW!DW".DV»DW!DW". >=18 and <65 Years and Not at RiskAB†Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB$mRNA-1273-P301 mRNA-1273-P301-US315-2499US3152499US315USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DW@DV»HrXv(DVØHr~©8DVØHr~©8DW"HrßîdDW@HsÀDW@HsÀ.DW]DV»DW!DW".DV»DW!DW". >=18 and <65 Years and Not at RiskAB†Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB$B$mômRNA-1273-P301 mRNA-1273-P301-US315-2522US3152522US315USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWSDVÁHr`-´DVßHr‡zôDVßHr‡zôDW8HrýÔDWSHs ¯øDWSHs ¯ø.DW]DVÁDW2DW3.DVÁDW7DW8. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BUmRNA-1273-P301 mRNA-1273-P301-US315-2523US3152523US315USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWSDVÁHr`KDVÝHr…èDVÝHr…èDW8Hrý(DWSHs ÈXDWSHs ÈX.DW]DVÁDW7DW8.DVÁDW7DW8. >=65 Years A0BNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BLmRNA-1273-P301 mRNA-1273-P301-US315-2523US3152523US315USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWSDVÁHr`KDVÝHr…èDVÝHr…èDW8Hrý(DWSHs ÈXDWSHs ÈX.DW]DVÁDW7DW8.DVÁDW7DW8. >=65 Years A0BNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BLBLmômRNA-1273-P301 mRNA-1273-P301-US315-2523US3152523US315USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWSDVÁHr`KDVÝHr…èDVÝHr…èDW8Hrý(DWSHs ÈXDWSHs ÈX.DW]DVÁDW7DW8.DVÁDW7DW8. >=65 Years A0BNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BLmôBLÛèmRNA-1273-P301 mRNA-1273-P301-US315-2523US3152523US315USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWSDVÁHr`KDVÝHr…èDVÝHr…èDW8Hrý(DWSHs ÈXDWSHs ÈX.DW]DVÁDW7DW8.DVÁDW7DW8. >=65 Years A0BNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BLÛèBLIÜmRNA-1273-P301 mRNA-1273-P301-US316-2028US3162028US316USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVnDVŠDVnHqò÷”DVŠHrâ„DVŠHrâ„.......DW]DVnDW=DW>.DVnDW=DW>. Diabetes >=65 Years A0BÔNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B—mRNA-1273-P301 mRNA-1273-P301-US316-2028US3162028US316USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVnDVŠDVnHqò÷”DVŠHrâ„DVŠHrâ„.......DW]DVnDW=DW>.DVnDW=DW>. Diabetes >=65 Years A0BÔNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B—B—mðmRNA-1273-P301 mRNA-1273-P301-US316-2028US3162028US316USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVnDVŠDVnHqò÷”DVŠHrâ„DVŠHrâ„.......DW]DVnDW=DW>.DVnDW=DW>. Diabetes >=65 Years A0BÔNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B—mðB—ÛèmRNA-1273-P301 mRNA-1273-P301-US316-2028US3162028US316USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVnDVŠDVnHqò÷”DVŠHrâ„DVŠHrâ„.......DW]DVnDW=DW>.DVnDW=DW>. Diabetes >=65 Years A0BÔNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B—ÛèB—IØmRNA-1273-P301 mRNA-1273-P301-US316-2034US3162034US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW:DVoHqô5dDV‹HrtDV‹HrtDW:Hrÿ•èDW:Hrÿ•è...DW]DVoDW9DW:.DVoDW9DW:. >=18 and <65 Years and Not at RiskABÓMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B”mRNA-1273-P301 mRNA-1273-P301-US316-2034US3162034US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW:DVoHqô5dDV‹HrtDV‹HrtDW:Hrÿ•èDW:Hrÿ•è...DW]DVoDW9DW:.DVoDW9DW:. >=18 and <65 Years and Not at RiskABÓMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B”B”mðmRNA-1273-P301 mRNA-1273-P301-US316-2034US3162034US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW:DVoHqô5dDV‹HrtDV‹HrtDW:Hrÿ•èDW:Hrÿ•è...DW]DVoDW9DW:.DVoDW9DW:. >=18 and <65 Years and Not at RiskABÓMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B”mðB”ÛèmRNA-1273-P301 mRNA-1273-P301-US316-2034US3162034US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW:DVoHqô5dDV‹HrtDV‹HrtDW:Hrÿ•èDW:Hrÿ•è...DW]DVoDW9DW:.DVoDW9DW:. >=18 and <65 Years and Not at RiskABÓMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B”ÛèB”IØmRNA-1273-P301 mRNA-1273-P301-US316-2040US3162040US316USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYYYYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVoDV‹DVoHqô]xDV‹HrLÜDV‹HrLÜ.......DW]DVoDWEDWF.DVoDWEDWF. >=18 and <65 Years and Not at RiskABÓMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BšmRNA-1273-P301 mRNA-1273-P301-US316-2040US3162040US316USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYYYYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVoDV‹DVoHqô]xDV‹HrLÜDV‹HrLÜ.......DW]DVoDWEDWF.DVoDWEDWF. >=18 and <65 Years and Not at RiskABÓMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BšBšmðmRNA-1273-P301 mRNA-1273-P301-US316-2040US3162040US316USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYYYYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVoDV‹DVoHqô]xDV‹HrLÜDV‹HrLÜ.......DW]DVoDWEDWF.DVoDWEDWF. >=18 and <65 Years and Not at RiskABÓMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BšmðBšÛèmRNA-1273-P301 mRNA-1273-P301-US316-2040US3162040US316USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYYYYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVoDV‹DVoHqô]xDV‹HrLÜDV‹HrLÜ.......DW]DVoDWEDWF.DVoDWEDWF. >=18 and <65 Years and Not at RiskABÓMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BšÛèBšIØmRNA-1273-P301 mRNA-1273-P301-US316-2044US3162044US316USAB8YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW]DVrHq÷ÒðDVŽHr¿üDVŽHr¿üDW?Hs „DW]Hs-žHDW]Hs-žH.DW]DVrDW>DW?.DVrDW>DW?. Severe Obesity >=18 and <65 Years and at Risk A BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BxmRNA-1273-P301 mRNA-1273-P301-US316-2044US3162044US316USAB8YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW]DVrHq÷ÒðDVŽHr¿üDVŽHr¿üDW?Hs „DW]Hs-žHDW]Hs-žH.DW]DVrDW>DW?.DVrDW>DW?. Severe Obesity >=18 and <65 Years and at Risk A BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BxBxmômRNA-1273-P301 mRNA-1273-P301-US316-2044US3162044US316USAB8YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW]DVrHq÷ÒðDVŽHr¿üDVŽHr¿üDW?Hs „DW]Hs-žHDW]Hs-žH.DW]DVrDW>DW?.DVrDW>DW?. Severe Obesity >=18 and <65 Years and at Risk A BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BxmôBxÛèmRNA-1273-P301 mRNA-1273-P301-US316-2047US3162047US316USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDWODVrHqø DVŽHr\DVŽHr\DW3HröFPDWOHs/$DWOHs/$.DW]DVrDW2DW3.DVrDW2DW3. Diabetes >=65 Years A0BÐMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBŽmRNA-1273-P301 mRNA-1273-P301-US316-2047US3162047US316USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDWODVrHqø DVŽHr\DVŽHr\DW3HröFPDWOHs/$DWOHs/$.DW]DVrDW2DW3.DVrDW2DW3. Diabetes >=65 Years A0BÐMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBŽBŽmðmRNA-1273-P301 mRNA-1273-P301-US316-2050US3162050US316USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYYYYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVsDVDVsHqù2DDVHrpDVHrp.......DW]DVsDW>DW?.DVsDW>DW?. >=18 and <65 Years and Not at RiskABÏMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B’mRNA-1273-P301 mRNA-1273-P301-US316-2051US3162051US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWEDVsHqù2øDVHr¡DVHr¡DWEHsllDWEHsll...DW]DVsDWDDWE.DVsDWDDWE. >=18 and <65 Years and Not at RiskABÎMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB…mRNA-1273-P301 mRNA-1273-P301-US316-2051US3162051US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWEDVsHqù2øDVHr¡DVHr¡DWEHsllDWEHsll...DW]DVsDWDDWE.DVsDWDDWE. >=18 and <65 Years and Not at RiskABÎMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB…B…mðmRNA-1273-P301 mRNA-1273-P301-US316-2057US3162057US316USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWHDVtHqú’ÄDVHrˆDVHrˆDWHHs"DWHHs"...DW]DVtDWGDWH.DVtDWGDWH. Diabetes >=65 Years A0BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBÊmRNA-1273-P301 mRNA-1273-P301-US316-2057US3162057US316USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWHDVtHqú’ÄDVHrˆDVHrˆDWHHs"DWHHs"...DW]DVtDWGDWH.DVtDWGDWH. Diabetes >=65 Years A0BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBÊBÊmðmRNA-1273-P301 mRNA-1273-P301-US316-2063US3162063US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWGDVtHqúÊDVHr²¬DVHr²¬DWGHsÎøDWGHsÎø...DW]DVtDWFDWG.DVtDWFDWG. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B}mRNA-1273-P301 mRNA-1273-P301-US316-2063US3162063US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWGDVtHqúÊDVHr²¬DVHr²¬DWGHsÎøDWGHsÎø...DW]DVtDWFDWG.DVtDWFDWG. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B}B}mômRNA-1273-P301 mRNA-1273-P301-US316-2063US3162063US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWGDVtHqúÊDVHr²¬DVHr²¬DWGHsÎøDWGHsÎø...DW]DVtDWFDWG.DVtDWFDWG. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B}môB}ÛèmRNA-1273-P301 mRNA-1273-P301-US316-2116US3162116US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW[DV|HraÌDVžHr2 ¨DVžHr2 ¨DW:HrÿÂ¬DW[Hs+cDW[Hs+c.DW]DV|DW9DW:.DV|DW9DW:. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B’mRNA-1273-P301 mRNA-1273-P301-US316-2116US3162116US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW[DV|HraÌDVžHr2 ¨DVžHr2 ¨DW:HrÿÂ¬DW[Hs+cDW[Hs+c.DW]DV|DW9DW:.DV|DW9DW:. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B’B’mðmRNA-1273-P301 mRNA-1273-P301-US316-2116US3162116US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW[DV|HraÌDVžHr2 ¨DVžHr2 ¨DW:HrÿÂ¬DW[Hs+cDW[Hs+c.DW]DV|DW9DW:.DV|DW9DW:. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B’mðB’ÛèmRNA-1273-P301 mRNA-1273-P301-US316-2116US3162116US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW[DV|HraÌDVžHr2 ¨DVžHr2 ¨DW:HrÿÂ¬DW[Hs+cDW[Hs+c.DW]DV|DW9DW:.DV|DW9DW:. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B’ÛèB’IØmRNA-1273-P301 mRNA-1273-P301-US316-2123US3162123US316USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV}DVžDV}HrŒ(DVžHr2HôDVžHr2Hô.......DW]DV}DWEDWF.DV}DWEDWF. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmRNA-1273-P301 mRNA-1273-P301-US316-2123US3162123US316USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV}DVžDV}HrŒ(DVžHr2HôDVžHr2Hô.......DW]DV}DWEDWF.DV}DWEDWF. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBmðmRNA-1273-P301 mRNA-1273-P301-US316-2149US3162149US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWDDV‚Hr GDVHr0âÔDVHr0âÔDWDHsûHDWDHsûH...DW]DV‚DWCDWD.DV‚DWCDWD. >=18 and <65 Years and Not at RiskABÁMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BkmRNA-1273-P301 mRNA-1273-P301-US316-2182US3162182US316USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVˆDV¤DVˆHr,ˆDV¤Hr9ê<DV¤Hr9ê<.......DW]DVˆDWDW.DVˆDWDW. >=65 Years A0BºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmRNA-1273-P301 mRNA-1273-P301-US316-2182US3162182US316USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVˆDV¤DVˆHr,ˆDV¤Hr9ê<DV¤Hr9ê<.......DW]DVˆDWDW.DVˆDWDW. >=65 Years A0BºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBmómRNA-1273-P301 mRNA-1273-P301-US316-2188US3162188US316USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWTDV‰HrcÈDV¥Hr;>ÈDV¥Hr;>ÈDW8HrýDWTHs!ö°DWTHs!ö°.DW]DV‰DW7DW8.DV‰DW7DW8. >=18 and <65 Years and Not at RiskAB¹Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BbmRNA-1273-P301 mRNA-1273-P301-US316-2188US3162188US316USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWTDV‰HrcÈDV¥Hr;>ÈDV¥Hr;>ÈDW8HrýDWTHs!ö°DWTHs!ö°.DW]DV‰DW7DW8.DV‰DW7DW8. >=18 and <65 Years and Not at RiskAB¹Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BbBbmômRNA-1273-P301 mRNA-1273-P301-US316-2188US3162188US316USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWTDV‰HrcÈDV¥Hr;>ÈDV¥Hr;>ÈDW8HrýDWTHs!ö°DWTHs!ö°.DW]DV‰DW7DW8.DV‰DW7DW8. >=18 and <65 Years and Not at RiskAB¹Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BbmôBbÛèmRNA-1273-P301 mRNA-1273-P301-US316-2188US3162188US316USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWTDV‰HrcÈDV¥Hr;>ÈDV¥Hr;>ÈDW8HrýDWTHs!ö°DWTHs!ö°.DW]DV‰DW7DW8.DV‰DW7DW8. >=18 and <65 Years and Not at RiskAB¹Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BbÛèBbIÜmRNA-1273-P301 mRNA-1273-P301-US316-2203US3162203US316USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWGDV‹HrPœDV¥Hr;‘HDV¥Hr;‘HDWGHs ÌDWGHs Ì...DW]DV‹DWFDWG.DV‹DWFDWG. >=18 and <65 Years and Not at RiskAB¹Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B~mRNA-1273-P301 mRNA-1273-P301-US316-2203US3162203US316USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWGDV‹HrPœDV¥Hr;‘HDV¥Hr;‘HDWGHs ÌDWGHs Ì...DW]DV‹DWFDWG.DV‹DWFDWG. >=18 and <65 Years and Not at RiskAB¹Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B~B~mômRNA-1273-P301 mRNA-1273-P301-US316-2203US3162203US316USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWGDV‹HrPœDV¥Hr;‘HDV¥Hr;‘HDWGHs ÌDWGHs Ì...DW]DV‹DWFDWG.DV‹DWFDWG. >=18 and <65 Years and Not at RiskAB¹Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B~môB~ÛèmRNA-1273-P301 mRNA-1273-P301-US316-2203US3162203US316USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWGDV‹HrPœDV¥Hr;‘HDV¥Hr;‘HDWGHs ÌDWGHs Ì...DW]DV‹DWFDWG.DV‹DWFDWG. >=18 and <65 Years and Not at RiskAB¹Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B~ÛèB~IÜmRNA-1273-P301 mRNA-1273-P301-US316-2215US3162215US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW]DVHráÈDV¬HrDÆdDV¬HrDÆdDW@HsÖÌDW]Hs. DW]Hs. .DW]DVDW<DW=.DVDW?DW@. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B`mRNA-1273-P301 mRNA-1273-P301-US316-2215US3162215US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW]DVHráÈDV¬HrDÆdDV¬HrDÆdDW@HsÖÌDW]Hs. DW]Hs. .DW]DVDW<DW=.DVDW?DW@. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B`B`mômRNA-1273-P301 mRNA-1273-P301-US316-2215US3162215US316USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW]DVHráÈDV¬HrDÆdDV¬HrDÆdDW@HsÖÌDW]Hs. DW]Hs. .DW]DVDW<DW=.DVDW?DW@. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B`môB`ÛèmRNA-1273-P301 mRNA-1273-P301-US316-2219US3162219US316USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DWZDV‘Hr!9ØDVHrF DVHrF DW9HrþhDWZHs)¿DWZHs)¿.DW]DV‘DW8DW9.DV‘DW8DW9. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BpmRNA-1273-P301 mRNA-1273-P301-US316-2219US3162219US316USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DWZDV‘Hr!9ØDVHrF DVHrF DW9HrþhDWZHs)¿DWZHs)¿.DW]DV‘DW8DW9.DV‘DW8DW9. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BpBpmômRNA-1273-P301 mRNA-1273-P301-US316-2219US3162219US316USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DWZDV‘Hr!9ØDVHrF DVHrF DW9HrþhDWZHs)¿DWZHs)¿.DW]DV‘DW8DW9.DV‘DW8DW9. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BpmôBpÛèmRNA-1273-P301 mRNA-1273-P301-US316-2261US3162261US316USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MAMERICAN INDIAN OR ALASKA NATIVE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWZDV±HrK&DVÍHrpDDVÍHrpDDW=HsÃ\DWZHs)úàDWZHs)úà.DW]DV±DW<DW=.DV±DW<DW=. >=18 and <65 Years and Not at RiskAB‘Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BNmRNA-1273-P301 mRNA-1273-P301-US316-2261US3162261US316USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MAMERICAN INDIAN OR ALASKA NATIVE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWZDV±HrK&DVÍHrpDDVÍHrpDDW=HsÃ\DWZHs)úàDWZHs)úà.DW]DV±DW<DW=.DV±DW<DW=. >=18 and <65 Years and Not at RiskAB‘Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BNBNmômRNA-1273-P301 mRNA-1273-P301-US316-2261US3162261US316USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MAMERICAN INDIAN OR ALASKA NATIVE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWZDV±HrK&DVÍHrpDDVÍHrpDDW=HsÃ\DWZHs)úàDWZHs)úà.DW]DV±DW<DW=.DV±DW<DW=. >=18 and <65 Years and Not at RiskAB‘Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BNmôBNÛèmRNA-1273-P301 mRNA-1273-P301-US316-2261US3162261US316USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MAMERICAN INDIAN OR ALASKA NATIVE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWZDV±HrK&DVÍHrpDDVÍHrpDDW=HsÃ\DWZHs)úàDWZHs)úà.DW]DV±DW<DW=.DV±DW<DW=. >=18 and <65 Years and Not at RiskAB‘Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BNÛèBNIÜmRNA-1273-P301 mRNA-1273-P301-US316-2271US3162271US316USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVµDWFDVµHrPo(DVÑHrubˆDVÑHrubˆDWFHs´PDWFHs´P...DW]DVµDWEDWF.DVµDWEDWF. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B5mRNA-1273-P301 mRNA-1273-P301-US316-2283US3162283US316USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DWZDV»HrXz`DV×Hr}XlDV×Hr}XlDW>HsôDWZHs*|DWZHs*|.DW]DV»DW=DW>.DV»DW=DW>. >=18 and <65 Years and Not at RiskAB‡Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB2mRNA-1273-P301 mRNA-1273-P301-US316-2283US3162283US316USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DWZDV»HrXz`DV×Hr}XlDV×Hr}XlDW>HsôDWZHs*|DWZHs*|.DW]DV»DW=DW>.DV»DW=DW>. >=18 and <65 Years and Not at RiskAB‡Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB2B2mômRNA-1273-P301 mRNA-1273-P301-US316-2299US3162299US316USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDWTDVÂHra^dDVÞHr†9(DVÞHr†9(DW7HrûšœDWTHs!ÚDWTHs!Ú.DW]DVÂDW6DW7.DVÂDW6DW7. Diabetes >=18 and <65 Years and at Risk A B€Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBRmRNA-1273-P301 mRNA-1273-P301-US316-2299US3162299US316USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDWTDVÂHra^dDVÞHr†9(DVÞHr†9(DW7HrûšœDWTHs!ÚDWTHs!Ú.DW]DVÂDW6DW7.DVÂDW6DW7. Diabetes >=18 and <65 Years and at Risk A B€Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBRBRmômRNA-1273-P301 mRNA-1273-P301-US316-2301US3162301US316USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDWZDVÂHra”DVÝHr…=4DVÝHr…=4DW>HsäDWZHs)ÑdDWZHs)Ñd.DW]DVÂDW=DW>.DVÂDW=DW>. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BCmRNA-1273-P301 mRNA-1273-P301-US316-2302US3162302US316USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVÃDVÞDVÃHrb¡ÔDVÞHr†2˜DVÞHr†2˜.......DW]DVÃDWEDWF.DVÃDWEDWF. >=18 and <65 Years and Not at RiskAB€Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB,mRNA-1273-P301 mRNA-1273-P301-US316-2302US3162302US316USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVÃDVÞDVÃHrb¡ÔDVÞHr†2˜DVÞHr†2˜.......DW]DVÃDWEDWF.DVÃDWEDWF. >=18 and <65 Years and Not at RiskAB€Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB,B,mômRNA-1273-P301 mRNA-1273-P301-US317-2043US3172043US317USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWGDVzHr™DV—Hr(ÙôDV—Hr(ÙôDW*Hrê¨DWGHs²`DWGHs²`.DW]DVzDW DW.DVzDW)DW*. >=18 and <65 Years and Not at RiskABÇMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B„mRNA-1273-P301 mRNA-1273-P301-US317-2102US3172102US317USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW9DV}Hr`TDV™Hr+A¨DV™Hr+A¨DWHrÙoDW9Hrþ1lDW9Hrþ1l.DW]DV}DW DW.DV}DWDW. >=65 Years A0BÅMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BEmRNA-1273-P301 mRNA-1273-P301-US317-2102US3172102US317USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW9DV}Hr`TDV™Hr+A¨DV™Hr+A¨DWHrÙoDW9Hrþ1lDW9Hrþ1l.DW]DV}DW DW.DV}DWDW. >=65 Years A0BÅMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BEBEmômRNA-1273-P301 mRNA-1273-P301-US317-2102US3172102US317USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW9DV}Hr`TDV™Hr+A¨DV™Hr+A¨DWHrÙoDW9Hrþ1lDW9Hrþ1l.DW]DV}DW DW.DV}DWDW. >=65 Years A0BÅMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BEmôBEÛèmRNA-1273-P301 mRNA-1273-P301-US317-2102US3172102US317USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW9DV}Hr`TDV™Hr+A¨DV™Hr+A¨DWHrÙoDW9Hrþ1lDW9Hrþ1l.DW]DV}DW DW.DV}DWDW. >=65 Years A0BÅMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BEÛèBEIÜmRNA-1273-P301 mRNA-1273-P301-US317-2105US3172105US317USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW9DV}HrzDV™Hr+: DV™Hr+: DWHrÙkHDW9Hrþ4<DW9Hrþ4<.DW]DV}DW DW.DV}DWDW. >=65 Years A0BÅMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BEmRNA-1273-P301 mRNA-1273-P301-US317-2105US3172105US317USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW9DV}HrzDV™Hr+: DV™Hr+: DWHrÙkHDW9Hrþ4<DW9Hrþ4<.DW]DV}DW DW.DV}DWDW. >=65 Years A0BÅMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BEBEmômRNA-1273-P301 mRNA-1273-P301-US317-2105US3172105US317USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW9DV}HrzDV™Hr+: DV™Hr+: DWHrÙkHDW9Hrþ4<DW9Hrþ4<.DW]DV}DW DW.DV}DWDW. >=65 Years A0BÅMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BEmôBEÛèmRNA-1273-P301 mRNA-1273-P301-US317-2105US3172105US317USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW9DV}HrzDV™Hr+: DV™Hr+: DWHrÙkHDW9Hrþ4<DW9Hrþ4<.DW]DV}DW DW.DV}DWDW. >=65 Years A0BÅMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BEÛèBEIÜmRNA-1273-P301 mRNA-1273-P301-US317-2234US3172234US317USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNNYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDVŸDVƒHrOlDVŸHr3,LDVŸHr3,L.......DW]DVƒ...DVƒ... Severe Obesity >=18 and <65 Years and at Risk A B¿Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B”mRNA-1273-P301 mRNA-1273-P301-US317-2462US3172462US317USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNNYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVÁDVÞDVÁHr`JLDVÞHr†LœDVÞHr†Lœ......DW\DW\DVÁ...DVÁ... Diabetes >=65 Years A0B€Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B[mRNA-1273-P301 mRNA-1273-P301-US318-2006US3182006US318USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWZDVkHqî¹@DV‡HräàDV‡HräàDWAHsê¨DWZHs)ÚÄDWZHs)ÚÄ.DW]DVkDW.DW/.DVkDW@DWA. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BœmRNA-1273-P301 mRNA-1273-P301-US318-2006US3182006US318USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWZDVkHqî¹@DV‡HräàDV‡HräàDWAHsê¨DWZHs)ÚÄDWZHs)ÚÄ.DW]DVkDW.DW/.DVkDW@DWA. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BœBœmðmRNA-1273-P301 mRNA-1273-P301-US318-2006US3182006US318USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWZDVkHqî¹@DV‡HräàDV‡HräàDWAHsê¨DWZHs)ÚÄDWZHs)ÚÄ.DW]DVkDW.DW/.DVkDW@DWA. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BœmðBœÛèmRNA-1273-P301 mRNA-1273-P301-US318-2006US3182006US318USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWZDVkHqî¹@DV‡HräàDV‡HräàDWAHsê¨DWZHs)ÚÄDWZHs)ÚÄ.DW]DVkDW.DW/.DVkDW@DWA. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BœÛèBœIØmRNA-1273-P301 mRNA-1273-P301-US318-2012US3182012US318USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWHDVkHqîä$DV„HrÉxDV„HrÉxDWHHsï@DWHHsï@...DW]DVkDWGDWH.DVkDWGDWH. >=18 and <65 Years and Not at RiskABÚNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BvmRNA-1273-P301 mRNA-1273-P301-US318-2012US3182012US318USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWHDVkHqîä$DV„HrÉxDV„HrÉxDWHHsï@DWHHsï@...DW]DVkDWGDWH.DVkDWGDWH. >=18 and <65 Years and Not at RiskABÚNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BvBvmômRNA-1273-P301 mRNA-1273-P301-US318-2012US3182012US318USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWHDVkHqîä$DV„HrÉxDV„HrÉxDWHHsï@DWHHsï@...DW]DVkDWGDWH.DVkDWGDWH. >=18 and <65 Years and Not at RiskABÚNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BvmôBvÛèmRNA-1273-P301 mRNA-1273-P301-US318-2012US3182012US318USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWHDVkHqîä$DV„HrÉxDV„HrÉxDWHHsï@DWHHsï@...DW]DVkDWGDWH.DVkDWGDWH. >=18 and <65 Years and Not at RiskABÚNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BvÛèBvIÜmRNA-1273-P301 mRNA-1273-P301-US318-2021US3182021US318USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVlDWVDVlHqïâ¬DV‹Hr¶(DV‹Hr¶(DW6Hrú)<DWVHs$QøDWVHs$Qø.DW]DVlDW5DW6.DVlDW5DW6. >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BImRNA-1273-P301 mRNA-1273-P301-US318-2021US3182021US318USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVlDWVDVlHqïâ¬DV‹Hr¶(DV‹Hr¶(DW6Hrú)<DWVHs$QøDWVHs$Qø.DW]DVlDW5DW6.DVlDW5DW6. >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BIBImômRNA-1273-P301 mRNA-1273-P301-US318-2021US3182021US318USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVlDWVDVlHqïâ¬DV‹Hr¶(DV‹Hr¶(DW6Hrú)<DWVHs$QøDWVHs$Qø.DW]DVlDW5DW6.DVlDW5DW6. >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BImôBIÛèmRNA-1273-P301 mRNA-1273-P301-US318-2050US3182050US318USAB2YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDWTDVmHqñM¸DVHr„DDVHr„DDW8HrüòpDWTHs!üPDWTHs!üP.DW]DVmDW7DW8.DVmDW7DW8. Diabetes >=18 and <65 Years and at Risk A BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B˜mRNA-1273-P301 mRNA-1273-P301-US318-2103US3182103US318USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWVDVoHqóá|DVHrûìDVHrûìDW8HrüÍhDWVHs$\„DWVHs$\„.DW]DVoDW7DW8.DVoDW7DW8. Severe Obesity >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B‰mRNA-1273-P301 mRNA-1273-P301-US318-2103US3182103US318USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWVDVoHqóá|DVHrûìDVHrûìDW8HrüÍhDWVHs$\„DWVHs$\„.DW]DVoDW7DW8.DVoDW7DW8. Severe Obesity >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B‰B‰mðmRNA-1273-P301 mRNA-1273-P301-US318-2103US3182103US318USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWVDVoHqóá|DVHrûìDVHrûìDW8HrüÍhDWVHs$\„DWVHs$\„.DW]DVoDW7DW8.DVoDW7DW8. Severe Obesity >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B‰mðB‰ÛèmRNA-1273-P301 mRNA-1273-P301-US318-2103US3182103US318USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDWVDVoHqóá|DVHrûìDVHrûìDW8HrüÍhDWVHs$\„DWVHs$\„.DW]DVoDW7DW8.DVoDW7DW8. Severe Obesity >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B‰ÛèB‰IØmRNA-1273-P301 mRNA-1273-P301-US318-2145US3182145US318USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWSDVsHqù)˜DVHrDVHrDW7HrûˆDWSHs h¸DWSHs h¸.DW]DVsDW6DW7.DVsDW6DW7. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BêmRNA-1273-P301 mRNA-1273-P301-US318-2238US3182238US318USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW:DVvHqý{`DV’Hr"0¤DV’Hr"0¤DWHrÎÆ¬DW:Hrÿ£DDW:Hrÿ£D.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BimRNA-1273-P301 mRNA-1273-P301-US318-2238US3182238US318USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW:DVvHqý{`DV’Hr"0¤DV’Hr"0¤DWHrÎÆ¬DW:Hrÿ£DDW:Hrÿ£D.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BiBimômRNA-1273-P301 mRNA-1273-P301-US318-2238US3182238US318USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW:DVvHqý{`DV’Hr"0¤DV’Hr"0¤DWHrÎÆ¬DW:Hrÿ£DDW:Hrÿ£D.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BimôBiÛèmRNA-1273-P301 mRNA-1273-P301-US318-2242US3182242US318USAB$YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW/DV}HrBÌDVœHr/#,DVœHr/#,DWHrÈÜDW/HrððœDW/Hrððœ.DW]DV}DWDW.DV}DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÂMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BfmRNA-1273-P301 mRNA-1273-P301-US318-2242US3182242US318USAB$YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW/DV}HrBÌDVœHr/#,DVœHr/#,DWHrÈÜDW/HrððœDW/Hrððœ.DW]DV}DWDW.DV}DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÂMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BfBfmômRNA-1273-P301 mRNA-1273-P301-US318-2242US3182242US318USAB$YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW/DV}HrBÌDVœHr/#,DVœHr/#,DWHrÈÜDW/HrððœDW/Hrððœ.DW]DV}DWDW.DV}DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÂMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BfmôBfÛèmRNA-1273-P301 mRNA-1273-P301-US318-2242US3182242US318USAB$YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW/DV}HrBÌDVœHr/#,DVœHr/#,DWHrÈÜDW/HrððœDW/Hrððœ.DW]DV}DWDW.DV}DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÂMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BfÛèBfIÜmRNA-1273-P301 mRNA-1273-P301-US318-2265US3182265US318USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDWZDVyHrrìDV–Hr'¤DV–Hr'¤DW>Hs&pDWZHs* àDWZHs* à.DW]DVyDW=DW>.DVyDW=DW>. >=18 and <65 Years and Not at RiskABÈMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BymRNA-1273-P301 mRNA-1273-P301-US318-2265US3182265US318USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDWZDVyHrrìDV–Hr'¤DV–Hr'¤DW>Hs&pDWZHs* àDWZHs* à.DW]DVyDW=DW>.DVyDW=DW>. >=18 and <65 Years and Not at RiskABÈMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3ByBymômRNA-1273-P301 mRNA-1273-P301-US318-2265US3182265US318USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDWZDVyHrrìDV–Hr'¤DV–Hr'¤DW>Hs&pDWZHs* àDWZHs* à.DW]DVyDW=DW>.DVyDW=DW>. >=18 and <65 Years and Not at RiskABÈMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BymôByÛèmRNA-1273-P301 mRNA-1273-P301-US318-2276US3182276US318USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW]DVzHrn,DVœHr/!LDVœHr/!LDWDHsªäDW]Hs-‘dDW]Hs-‘d.DW]DVzDWCDWD.DVzDWCDWD. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BjmRNA-1273-P301 mRNA-1273-P301-US318-2283US3182283US318USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVzDV—DVzHrˆ0DV—Hr(ôDV—Hr(ô.......DW]DVzDW<DW=.DVzDW<DW=. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BimRNA-1273-P301 mRNA-1273-P301-US319-2111US3192111US319USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWHDVvHqý|PDV’Hr"g¸DV’Hr"g¸DW,Hrí_|DWHHs;¨DWHHs;¨.DW]DVvDW+DW,.DVvDW+DW,. >=18 and <65 Years and Not at RiskABÌNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB~mRNA-1273-P301 mRNA-1273-P301-US319-2111US3192111US319USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWHDVvHqý|PDV’Hr"g¸DV’Hr"g¸DW,Hrí_|DWHHs;¨DWHHs;¨.DW]DVvDW+DW,.DVvDW+DW,. >=18 and <65 Years and Not at RiskABÌNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB~B~mômRNA-1273-P301 mRNA-1273-P301-US319-2155US3192155US319USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVyDV’DVyHr`DV’Hr!ñ˜DV’Hr!ñ˜.......DW]DVyDWCDWD.DVyDWCDWD. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBzmRNA-1273-P301 mRNA-1273-P301-US319-2155US3192155US319USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVyDV’DVyHr`DV’Hr!ñ˜DV’Hr!ñ˜.......DW]DVyDWCDWD.DVyDWCDWD. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBzBzmômRNA-1273-P301 mRNA-1273-P301-US319-2201US3192201US319USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWLDV{HrÑ¸DV˜Hr*]$DV˜Hr*]$DW,Hrí¸DWLHs-üDWLHs-ü.DW]DV{DW+DW,.DV{DW+DW,. >=18 and <65 Years and Not at RiskABÆMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BhmRNA-1273-P301 mRNA-1273-P301-US319-2201US3192201US319USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWLDV{HrÑ¸DV˜Hr*]$DV˜Hr*]$DW,Hrí¸DWLHs-üDWLHs-ü.DW]DV{DW+DW,.DV{DW+DW,. >=18 and <65 Years and Not at RiskABÆMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BhBhmômRNA-1273-P301 mRNA-1273-P301-US319-2201US3192201US319USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWLDV{HrÑ¸DV˜Hr*]$DV˜Hr*]$DW,Hrí¸DWLHs-üDWLHs-ü.DW]DV{DW+DW,.DV{DW+DW,. >=18 and <65 Years and Not at RiskABÆMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BhmôBhÛèmRNA-1273-P301 mRNA-1273-P301-US319-2203US3192203US319USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV{DV™DV{Hrâ˜DV™Hr+3 DV™Hr+3 .......DW]DV{DW?DW@.DV{DW?DW@. Severe Obesity >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BœmRNA-1273-P301 mRNA-1273-P301-US319-2203US3192203US319USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV{DV™DV{Hrâ˜DV™Hr+3 DV™Hr+3 .......DW]DV{DW?DW@.DV{DW?DW@. Severe Obesity >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BœBœmðmRNA-1273-P301 mRNA-1273-P301-US319-2203US3192203US319USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV{DV™DV{Hrâ˜DV™Hr+3 DV™Hr+3 .......DW]DV{DW?DW@.DV{DW?DW@. Severe Obesity >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BœmðBœÛèmRNA-1273-P301 mRNA-1273-P301-US319-2335US3192335US319USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWEDVˆHrÑ DV¤Hr9¾àDV¤Hr9¾àDW)Hré ìDWEHsBDWEHsB.DW]DVˆDW(DW).DVˆDW(DW). >=65 Years A0BºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BqmRNA-1273-P301 mRNA-1273-P301-US319-2335US3192335US319USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWEDVˆHrÑ DV¤Hr9¾àDV¤Hr9¾àDW)Hré ìDWEHsBDWEHsB.DW]DVˆDW(DW).DVˆDW(DW). >=65 Years A0BºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BqBqmômRNA-1273-P301 mRNA-1273-P301-US319-2335US3192335US319USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWEDVˆHrÑ DV¤Hr9¾àDV¤Hr9¾àDW)Hré ìDWEHsBDWEHsB.DW]DVˆDW(DW).DVˆDW(DW). >=65 Years A0BºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BqmôBqÛèmRNA-1273-P301 mRNA-1273-P301-US319-2400US3192400US319USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW[DV„HrÝÜDV Hr4s¸DV Hr4s¸DW?Hs08DW[Hs*øDW[Hs*ø.DW]DV„DW>DW?.DV„DW>DW?. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B“mRNA-1273-P301 mRNA-1273-P301-US319-2400US3192400US319USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW[DV„HrÝÜDV Hr4s¸DV Hr4s¸DW?Hs08DW[Hs*øDW[Hs*ø.DW]DV„DW>DW?.DV„DW>DW?. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B“B“mðmRNA-1273-P301 mRNA-1273-P301-US319-2400US3192400US319USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW[DV„HrÝÜDV Hr4s¸DV Hr4s¸DW?Hs08DW[Hs*øDW[Hs*ø.DW]DV„DW>DW?.DV„DW>DW?. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B“mðB“ÛèmRNA-1273-P301 mRNA-1273-P301-US319-2417US3192417US319USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWGDV…HrŒDV¢Hr7&lDV¢Hr7&lDW+Hrë®ÔDWGHs¬„DWGHs¬„.DW]DV…DW*DW+.DV…DW*DW+. >=18 and <65 Years and Not at RiskAB¼Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‚mRNA-1273-P301 mRNA-1273-P301-US319-2441US3192441US319USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DWRDV†Hr’¬DV¢Hr7m4DV¢Hr7m4DW8HrüÓDWRHskÔDWRHskÔ.DW]DV†DW(DW).DV†DW7DW8. Severe ObesityDiabetesLiver Disease >=18 and <65 Years and at Risk A B¼Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B†mRNA-1273-P301 mRNA-1273-P301-US319-2441US3192441US319USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DWRDV†Hr’¬DV¢Hr7m4DV¢Hr7m4DW8HrüÓDWRHskÔDWRHskÔ.DW]DV†DW(DW).DV†DW7DW8. Severe ObesityDiabetesLiver Disease >=18 and <65 Years and at Risk A B¼Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B†B†mðmRNA-1273-P301 mRNA-1273-P301-US319-2441US3192441US319USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DWRDV†Hr’¬DV¢Hr7m4DV¢Hr7m4DW8HrüÓDWRHskÔDWRHskÔ.DW]DV†DW(DW).DV†DW7DW8. Severe ObesityDiabetesLiver Disease >=18 and <65 Years and at Risk A B¼Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B†mðB†ÛèmRNA-1273-P301 mRNA-1273-P301-US319-2458US3192458US319USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWEDV‡HrÈüDV£Hr8·pDV£Hr8·pDW)HréeÔDWEHs?äDWEHs?ä.DW]DV‡DW(DW).DV‡DW(DW). >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BkmRNA-1273-P301 mRNA-1273-P301-US319-2458US3192458US319USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWEDV‡HrÈüDV£Hr8·pDV£Hr8·pDW)HréeÔDWEHs?äDWEHs?ä.DW]DV‡DW(DW).DV‡DW(DW). >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BkBkmômRNA-1273-P301 mRNA-1273-P301-US319-2458US3192458US319USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWEDV‡HrÈüDV£Hr8·pDV£Hr8·pDW)HréeÔDWEHs?äDWEHs?ä.DW]DV‡DW(DW).DV‡DW(DW). >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BkmôBkÛèmRNA-1273-P301 mRNA-1273-P301-US319-2466US3192466US319USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWKDVˆHrÑÔDV¤Hr9»\DV¤Hr9»\DW/Hrðþ4DWKHsâÐDWKHsâÐ.DW]DVˆDW.DW/.DVˆDW.DW/. Diabetes >=18 and <65 Years and at Risk A BºNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B}mRNA-1273-P301 mRNA-1273-P301-US319-2466US3192466US319USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWKDVˆHrÑÔDV¤Hr9»\DV¤Hr9»\DW/Hrðþ4DWKHsâÐDWKHsâÐ.DW]DVˆDW.DW/.DVˆDW.DW/. Diabetes >=18 and <65 Years and at Risk A BºNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B}B}mômRNA-1273-P301 mRNA-1273-P301-US319-2466US3192466US319USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWKDVˆHrÑÔDV¤Hr9»\DV¤Hr9»\DW/Hrðþ4DWKHsâÐDWKHsâÐ.DW]DVˆDW.DW/.DVˆDW.DW/. Diabetes >=18 and <65 Years and at Risk A BºNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B}môB}ÛèmRNA-1273-P301 mRNA-1273-P301-US319-2487US3192487US319USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‰DV¥DV‰HràDV¥Hr;lDV¥Hr;l.......DW]DV‰DWR..DV‰DWR.. >=18 and <65 Years and Not at RiskAB®Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BumRNA-1273-P301 mRNA-1273-P301-US319-2487US3192487US319USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‰DV¥DV‰HràDV¥Hr;lDV¥Hr;l.......DW]DV‰DWR..DV‰DWR.. >=18 and <65 Years and Not at RiskAB®Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BuBumômRNA-1273-P301 mRNA-1273-P301-US319-2487US3192487US319USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‰DV¥DV‰HràDV¥Hr;lDV¥Hr;l.......DW]DV‰DWR..DV‰DWR.. >=18 and <65 Years and Not at RiskAB®Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BumôBuÛèmRNA-1273-P301 mRNA-1273-P301-US319-2487US3192487US319USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‰DV¥DV‰HràDV¥Hr;lDV¥Hr;l.......DW]DV‰DWR..DV‰DWR.. >=18 and <65 Years and Not at RiskAB®Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BuÛèBuIÜmRNA-1273-P301 mRNA-1273-P301-US319-2501US3192501US319USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰HrnÌDV¥Hr; PDV¥Hr; PDW'Hræ›°DWEHs €DWEHs €.DW]DV‰DW&DW'.DV‰DW&DW'. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B`mRNA-1273-P301 mRNA-1273-P301-US319-2501US3192501US319USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰HrnÌDV¥Hr; PDV¥Hr; PDW'Hræ›°DWEHs €DWEHs €.DW]DV‰DW&DW'.DV‰DW&DW'. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B`B`mômRNA-1273-P301 mRNA-1273-P301-US319-2501US3192501US319USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰HrnÌDV¥Hr; PDV¥Hr; PDW'Hræ›°DWEHs €DWEHs €.DW]DV‰DW&DW'.DV‰DW&DW'. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B`môB`ÛèmRNA-1273-P301 mRNA-1273-P301-US319-2501US3192501US319USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰HrnÌDV¥Hr; PDV¥Hr; PDW'Hræ›°DWEHs €DWEHs €.DW]DV‰DW&DW'.DV‰DW&DW'. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B`ÛèB`IÜmRNA-1273-P301 mRNA-1273-P301-US319-2531US3192531US319USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVŠDV¨DVŠHrêDV¨Hr?sDDV¨Hr?sD......DVûDVûDVŠDVü..DVŠDVü.. >=18 and <65 Years and Not at RiskABUMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BQmRNA-1273-P301 mRNA-1273-P301-US319-2531US3192531US319USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVŠDV¨DVŠHrêDV¨Hr?sDDV¨Hr?sD......DVûDVûDVŠDVü..DVŠDVü.. >=18 and <65 Years and Not at RiskABUMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BQBQmômRNA-1273-P301 mRNA-1273-P301-US319-2531US3192531US319USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVŠDV¨DVŠHrêDV¨Hr?sDDV¨Hr?sD......DVûDVûDVŠDVü..DVŠDVü.. >=18 and <65 Years and Not at RiskABUMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BQmôBQÛèmRNA-1273-P301 mRNA-1273-P301-US319-2563US3192563US319USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWFDV‹Hr@4DV§Hr>8DV§Hr>8DW(Hrè,DWFHs«,DWFHs«,.DW]DV‹DW'DW(.DV‹DW'DW(. >=18 and <65 Years and Not at RiskAB·Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BamRNA-1273-P301 mRNA-1273-P301-US319-2563US3192563US319USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWFDV‹Hr@4DV§Hr>8DV§Hr>8DW(Hrè,DWFHs«,DWFHs«,.DW]DV‹DW'DW(.DV‹DW'DW(. >=18 and <65 Years and Not at RiskAB·Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BaBamômRNA-1273-P301 mRNA-1273-P301-US319-2563US3192563US319USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWFDV‹Hr@4DV§Hr>8DV§Hr>8DW(Hrè,DWFHs«,DWFHs«,.DW]DV‹DW'DW(.DV‹DW'DW(. >=18 and <65 Years and Not at RiskAB·Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BamôBaÛèmRNA-1273-P301 mRNA-1273-P301-US319-2563US3192563US319USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWFDV‹Hr@4DV§Hr>8DV§Hr>8DW(Hrè,DWFHs«,DWFHs«,.DW]DV‹DW'DW(.DV‹DW'DW(. >=18 and <65 Years and Not at RiskAB·Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BaÛèBaIÜmRNA-1273-P301 mRNA-1273-P301-US319-2564US3192564US319USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DW*DV‹HrGðDV§Hr=¬XDV§Hr=¬XDWHrÅŒ,DW*HrêŽPDW*HrêŽP.DW]DV‹DW DW.DV‹DW DW. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBemRNA-1273-P301 mRNA-1273-P301-US319-2564US3192564US319USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DW*DV‹HrGðDV§Hr=¬XDV§Hr=¬XDWHrÅŒ,DW*HrêŽPDW*HrêŽP.DW]DV‹DW DW.DV‹DW DW. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBeBemômRNA-1273-P301 mRNA-1273-P301-US319-2569US3192569US319USABLYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVŒDV¨DVŒHr0DV¨Hr>óLDV¨Hr>óL.......DW]DVŒDW1..DVŒDW1.. Diabetes >=65 Years A0BŠNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB„mRNA-1273-P301 mRNA-1273-P301-US319-2569US3192569US319USABLYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVŒDV¨DVŒHr0DV¨Hr>óLDV¨Hr>óL.......DW]DVŒDW1..DVŒDW1.. Diabetes >=65 Years A0BŠNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB„B„mðmRNA-1273-P301 mRNA-1273-P301-US319-2622US3192622US319USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FAMERICAN INDIAN OR ALASKA NATIVE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW]DVHr<œDV¨Hr?€DV¨Hr?€DWAHsÌ0DW]Hs-¾ DW]Hs-¾ .DW]DVDW*DW+.DVDW@DWA. >=18 and <65 Years and Not at RiskAB¶Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B}mRNA-1273-P301 mRNA-1273-P301-US319-2622US3192622US319USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FAMERICAN INDIAN OR ALASKA NATIVE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW]DVHr<œDV¨Hr?€DV¨Hr?€DWAHsÌ0DW]Hs-¾ DW]Hs-¾ .DW]DVDW*DW+.DVDW@DWA. >=18 and <65 Years and Not at RiskAB¶Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B}B}mômRNA-1273-P301 mRNA-1273-P301-US319-2622US3192622US319USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FAMERICAN INDIAN OR ALASKA NATIVE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW]DVHr<œDV¨Hr?€DV¨Hr?€DWAHsÌ0DW]Hs-¾ DW]Hs-¾ .DW]DVDW*DW+.DVDW@DWA. >=18 and <65 Years and Not at RiskAB¶Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B}môB}ÛèmRNA-1273-P301 mRNA-1273-P301-US319-2626US3192626US319USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW\DVHrLDV«HrC1ÜDV«HrC1ÜDWAHsÝLDW\Hs,qDW\Hs,q.DW]DVDW@DWA.DVDW@DWA. >=18 and <65 Years and Not at RiskAB³Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB“mRNA-1273-P301 mRNA-1273-P301-US319-2626US3192626US319USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW\DVHrLDV«HrC1ÜDV«HrC1ÜDWAHsÝLDW\Hs,qDW\Hs,q.DW]DVDW@DWA.DVDW@DWA. >=18 and <65 Years and Not at RiskAB³Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB“B“mðmRNA-1273-P301 mRNA-1273-P301-US319-2638US3192638US319USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWEDVHrj@DVªHrB $DVªHrB $DW'Hræj<DWEHsdìDWEHsdì.DW]DVDW&DW'.DVDW&DW'. Human Immunodeficiency Virus Infection>=18 and <65 Years and at Risk A B´Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBgmRNA-1273-P301 mRNA-1273-P301-US319-2638US3192638US319USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWEDVHrj@DVªHrB $DVªHrB $DW'Hræj<DWEHsdìDWEHsdì.DW]DVDW&DW'.DVDW&DW'. Human Immunodeficiency Virus Infection>=18 and <65 Years and at Risk A B´Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBgBgmômRNA-1273-P301 mRNA-1273-P301-US319-2732US3192732US319USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV°DW+DV°HrI´DVÍHrp6ÈDVÍHrp6ÈDWHrÇAHDW+Hrì¤DW+Hrì¤.DW]DV°DWDW.DV°DWDW. >=18 and <65 Years and Not at RiskAB‘Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBDmRNA-1273-P301 mRNA-1273-P301-US319-2732US3192732US319USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV°DW+DV°HrI´DVÍHrp6ÈDVÍHrp6ÈDWHrÇAHDW+Hrì¤DW+Hrì¤.DW]DV°DWDW.DV°DWDW. >=18 and <65 Years and Not at RiskAB‘Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBDBDmômRNA-1273-P301 mRNA-1273-P301-US319-2824US3192824US319USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MAMERICAN INDIAN OR ALASKA NATIVE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DWADV»HrX!PDV×Hr}(DV×Hr}(DW&Hrå)$DWAHs ¬DWAHs ¬.DW]DV»DW%DW&.DV»DW%DW&. Severe Obesity >=18 and <65 Years and at Risk A B‡Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB8mRNA-1273-P301 mRNA-1273-P301-US319-2824US3192824US319USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MAMERICAN INDIAN OR ALASKA NATIVE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DWADV»HrX!PDV×Hr}(DV×Hr}(DW&Hrå)$DWAHs ¬DWAHs ¬.DW]DV»DW%DW&.DV»DW%DW&. Severe Obesity >=18 and <65 Years and at Risk A B‡Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB8B8mômRNA-1273-P301 mRNA-1273-P301-US319-2856US3192856US319USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¿DW]DV¿Hr]gÈDVØHr~{üDVØHr~{üDW@HsÑhDW]Hs.ôDW]Hs.ô.DW]DV¿DW+DW,.DV¿DW?DW@. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BPmRNA-1273-P301 mRNA-1273-P301-US319-2856US3192856US319USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¿DW]DV¿Hr]gÈDVØHr~{üDVØHr~{üDW@HsÑhDW]Hs.ôDW]Hs.ô.DW]DV¿DW+DW,.DV¿DW?DW@. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BPBPmômRNA-1273-P301 mRNA-1273-P301-US319-2856US3192856US319USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¿DW]DV¿Hr]gÈDVØHr~{üDVØHr~{üDW@HsÑhDW]Hs.ôDW]Hs.ô.DW]DV¿DW+DW,.DV¿DW?DW@. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BPmôBPÛèmRNA-1273-P301 mRNA-1273-P301-US319-2856US3192856US319USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¿DW]DV¿Hr]gÈDVØHr~{üDVØHr~{üDW@HsÑhDW]Hs.ôDW]Hs.ô.DW]DV¿DW+DW,.DV¿DW?DW@. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BPÛèBPIÜmRNA-1273-P301 mRNA-1273-P301-US319-2906US3192906US319USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVÂDVÞDVÂHra‰HDVÞHr†qhDVÞHr†qh.......DW]DVÂDW&DW'DWRDVÂDW&DW'DWR Significant Cardiac Disease >=65 Years A0BuNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB+mRNA-1273-P301 mRNA-1273-P301-US319-2906US3192906US319USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVÂDVÞDVÂHra‰HDVÞHr†qhDVÞHr†qh.......DW]DVÂDW&DW'DWRDVÂDW&DW'DWR Significant Cardiac Disease >=65 Years A0BuNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB+B+mômRNA-1273-P301 mRNA-1273-P301-US320-2017US3202017US320USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYNYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDVDVtHqúÒHDVHru¼DVHru¼.......DW]DVtDW/DW0.DVtDW/DW0. >=18 and <65 Years and Not at RiskABÎMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BŒmRNA-1273-P301 mRNA-1273-P301-US320-2047US3202047US320USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW@DVvHqý)ÐDV™Hr+PlDV™Hr+PlDWHrÚØ4DW@Hs¶8DW@Hs¶8.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B[mRNA-1273-P301 mRNA-1273-P301-US320-2047US3202047US320USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW@DVvHqý)ÐDV™Hr+PlDV™Hr+PlDWHrÚØ4DW@Hs¶8DW@Hs¶8.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B[B[mômRNA-1273-P301 mRNA-1273-P301-US320-2047US3202047US320USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW@DVvHqý)ÐDV™Hr+PlDV™Hr+PlDWHrÚØ4DW@Hs¶8DW@Hs¶8.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B[môB[ÛèmRNA-1273-P301 mRNA-1273-P301-US320-2152US3202152US320USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV{DV—DV{Hrü$DV—Hr(åpDV—Hr(åp.......DW]DV{DVùDVúDVúDV{DVùDVúDVú Severe Obesity >=18 and <65 Years and at Risk A BdNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B(mRNA-1273-P301 mRNA-1273-P301-US320-2154US3202154US320USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWNDV{Hrÿ¨DVHr08DVHr08DWNHsì¤DWNHsì¤...DW]DV{DWMDWN.DV{DWMDWN. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBƒmRNA-1273-P301 mRNA-1273-P301-US320-2154US3202154US320USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWNDV{Hrÿ¨DVHr08DVHr08DWNHsì¤DWNHsì¤...DW]DV{DWMDWN.DV{DWMDWN. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBƒBƒmðmRNA-1273-P301 mRNA-1273-P301-US320-2210US3202210US320USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWLDV~HrÍ@DVŸHr3‹8DVŸHr3‹8DWLHs„ðDWLHs„ð...DW]DV~DW(DW).DV~DWKDWL. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B]mRNA-1273-P301 mRNA-1273-P301-US320-2210US3202210US320USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWLDV~HrÍ@DVŸHr3‹8DVŸHr3‹8DWLHs„ðDWLHs„ð...DW]DV~DW(DW).DV~DWKDWL. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B]B]mômRNA-1273-P301 mRNA-1273-P301-US320-2210US3202210US320USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWLDV~HrÍ@DVŸHr3‹8DVŸHr3‹8DWLHs„ðDWLHs„ð...DW]DV~DW(DW).DV~DWKDWL. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B]môB]ÛèmRNA-1273-P301 mRNA-1273-P301-US320-2253US3202253US320USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWGDV‚HrøˆDVŸHr3kDVŸHr3kDW+HrëÚäDWGHsÄ0DWGHsÄ0.DW]DV‚DW*DW+.DV‚DW*DW+. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmRNA-1273-P301 mRNA-1273-P301-US320-2268US3202268US320USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW)DVƒHrEÐDVŸHr3-<DVŸHr3-<DWHrÂâØDW)Hré(DW)Hré(.DW]DVƒDWDW.DVƒDWDW. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BamRNA-1273-P301 mRNA-1273-P301-US320-2314US3202314US320USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHrã,DV¤Hr9ÄDDV¤Hr9ÄD.......DW]DVˆDWDWDWDVˆDWDWDW >=18 and <65 Years and Not at RiskABxNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB}mRNA-1273-P301 mRNA-1273-P301-US320-2314US3202314US320USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHrã,DV¤Hr9ÄDDV¤Hr9ÄD.......DW]DVˆDWDWDWDVˆDWDWDW >=18 and <65 Years and Not at RiskABxNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB}B}mômRNA-1273-P301 mRNA-1273-P301-US320-2328US3202328US320USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW9DV‰Hr,DV£Hr8plDV£Hr8plDWHrÚ¤,DW9Hrþ?¸DW9Hrþ?¸.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBamRNA-1273-P301 mRNA-1273-P301-US320-2328US3202328US320USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW9DV‰Hr,DV£Hr8plDV£Hr8plDWHrÚ¤,DW9Hrþ?¸DW9Hrþ?¸.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBaBamômRNA-1273-P301 mRNA-1273-P301-US320-2346US3202346US320USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW=DVŠHr¬`DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB+mRNA-1273-P301 mRNA-1273-P301-US320-2346US3202346US320USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW=DVŠHr¬`DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB+B+mômRNA-1273-P301 mRNA-1273-P301-US320-2350US3202350US320USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW+DVŠHrÈøDV²HrLpÐDV²HrLpÐDWHrÆÇàDW+Hrë±¤DW+Hrë±¤.DW]DVŠDWDW.DVŠDWDW. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BjmRNA-1273-P301 mRNA-1273-P301-US320-2405US3202405US320USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW)DV—Hr(ôèDV³HrMÆLDV³HrMÆLDWHrÂáèDW)Hré\8DW)Hré\8.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB«Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BRmRNA-1273-P301 mRNA-1273-P301-US320-2405US3202405US320USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW)DV—Hr(ôèDV³HrMÆLDV³HrMÆLDWHrÂáèDW)Hré\8DW)Hré\8.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB«Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BRBRmômRNA-1273-P301 mRNA-1273-P301-US320-2405US3202405US320USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW)DV—Hr(ôèDV³HrMÆLDV³HrMÆLDWHrÂáèDW)Hré\8DW)Hré\8.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB«Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BRmôBRÛèmRNA-1273-P301 mRNA-1273-P301-US321-2027US3212027US321USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWFDVsHqùGÔDVHr9DVHr9DWFHs[|DWFHs[|...DW]DVsDWEDWF.DVsDWEDWF. >=18 and <65 Years and Not at RiskABÏMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‡mRNA-1273-P301 mRNA-1273-P301-US321-2044US3212044US321USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW=DVtHqúäDVHrtDVHrtDWHrÅ’€DW=Hs«°DW=Hs«°.DW]DVtDW DW.DVtDW DW. >=18 and <65 Years and Not at RiskABÎNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B8mRNA-1273-P301 mRNA-1273-P301-US321-2044US3212044US321USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW=DVtHqúäDVHrtDVHrtDWHrÅ’€DW=Hs«°DW=Hs«°.DW]DVtDW DW.DVtDW DW. >=18 and <65 Years and Not at RiskABÎNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B8B8mômRNA-1273-P301 mRNA-1273-P301-US321-2044US3212044US321USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW=DVtHqúäDVHrtDVHrtDWHrÅ’€DW=Hs«°DW=Hs«°.DW]DVtDW DW.DVtDW DW. >=18 and <65 Years and Not at RiskABÎNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B8môB8ÛæmRNA-1273-P301 mRNA-1273-P301-US321-2115US3212115US321USABRYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWLDVzHrlLDV–Hr'gàDV–Hr'gàDW/Hrñ\DWLHs†XDWLHs†X.DW]DVzDW.DW/.DVzDW.DW/. >=65 Years A0BÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BymRNA-1273-P301 mRNA-1273-P301-US321-2133US3212133US321USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT REPORTED YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWYDVzHrÉDV™Hr+¥øDV™Hr+¥øDW:HrÿÙ,DWYHs(±XDWYHs(±X.DW]DVzDW9DW:.DVzDW9DW:. >=18 and <65 Years and Not at RiskABÅMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B{mRNA-1273-P301 mRNA-1273-P301-US321-2133US3212133US321USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT REPORTED YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWYDVzHrÉDV™Hr+¥øDV™Hr+¥øDW:HrÿÙ,DWYHs(±XDWYHs(±X.DW]DVzDW9DW:.DVzDW9DW:. >=18 and <65 Years and Not at RiskABÅMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B{B{mômRNA-1273-P301 mRNA-1273-P301-US321-2133US3212133US321USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT REPORTED YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWYDVzHrÉDV™Hr+¥øDV™Hr+¥øDW:HrÿÙ,DWYHs(±XDWYHs(±X.DW]DVzDW9DW:.DVzDW9DW:. >=18 and <65 Years and Not at RiskABÅMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B{môB{ÛèmRNA-1273-P301 mRNA-1273-P301-US321-2140US3212140US321USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWRDV{HrÊìDV—Hr)ôDV—Hr)ôDW3Hrö€DWRHs>\DWRHs>\.DW]DV{DW2DW3.DV{DW2DW3. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BxmRNA-1273-P301 mRNA-1273-P301-US321-2140US3212140US321USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWRDV{HrÊìDV—Hr)ôDV—Hr)ôDW3Hrö€DWRHs>\DWRHs>\.DW]DV{DW2DW3.DV{DW2DW3. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BxBxmômRNA-1273-P301 mRNA-1273-P301-US321-2140US3212140US321USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWRDV{HrÊìDV—Hr)ôDV—Hr)ôDW3Hrö€DWRHs>\DWRHs>\.DW]DV{DW2DW3.DV{DW2DW3. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BxmôBxÛèmRNA-1273-P301 mRNA-1273-P301-US321-2140US3212140US321USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWRDV{HrÊìDV—Hr)ôDV—Hr)ôDW3Hrö€DWRHs>\DWRHs>\.DW]DV{DW2DW3.DV{DW2DW3. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BxÛèBxIÜmRNA-1273-P301 mRNA-1273-P301-US321-2149US3212149US321USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWDDV{HrÔDV—Hr(ÜˆDV—Hr(ÜˆDW%Hrä˜DWDHsüìDWDHsüì.DW]DV{DW$DW%.DV{DW$DW%. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BrmRNA-1273-P301 mRNA-1273-P301-US321-2149US3212149US321USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWDDV{HrÔDV—Hr(ÜˆDV—Hr(ÜˆDW%Hrä˜DWDHsüìDWDHsüì.DW]DV{DW$DW%.DV{DW$DW%. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BrBrmômRNA-1273-P301 mRNA-1273-P301-US321-2149US3212149US321USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWDDV{HrÔDV—Hr(ÜˆDV—Hr(ÜˆDW%Hrä˜DWDHsüìDWDHsüì.DW]DV{DW$DW%.DV{DW$DW%. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BrmôBrÛèmRNA-1273-P301 mRNA-1273-P301-US321-2149US3212149US321USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWDDV{HrÔDV—Hr(ÜˆDV—Hr(ÜˆDW%Hrä˜DWDHsüìDWDHsüì.DW]DV{DW$DW%.DV{DW$DW%. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BrÛèBrIÜmRNA-1273-P301 mRNA-1273-P301-US321-2150US3212150US321USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV{DVDV{HrDVHr0ßÈDVHr0ßÈ.......DW]DV{DWRDWSDWSDV{DWRDWSDWS >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B¨mRNA-1273-P301 mRNA-1273-P301-US321-2150US3212150US321USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV{DVDV{HrDVHr0ßÈDVHr0ßÈ.......DW]DV{DWRDWSDWSDV{DWRDWSDWS >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B¨B¨mðmRNA-1273-P301 mRNA-1273-P301-US321-2150US3212150US321USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV{DVDV{HrDVHr0ßÈDVHr0ßÈ.......DW]DV{DWRDWSDWSDV{DWRDWSDWS >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B¨mðB¨ÛèmRNA-1273-P301 mRNA-1273-P301-US321-2151US3212151US321USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW1DV{Hr¤DV—Hr(åèDV—Hr(åèDWHrÅÒ|DW1Hróï@DW1Hróï@.DW]DV{DW DW.DV{DW DW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBYmRNA-1273-P301 mRNA-1273-P301-US321-2151US3212151US321USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW1DV{Hr¤DV—Hr(åèDV—Hr(åèDWHrÅÒ|DW1Hróï@DW1Hróï@.DW]DV{DW DW.DV{DW DW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBYBYmômRNA-1273-P301 mRNA-1273-P301-US321-2179US3212179US321USAB=YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV}DV™DV}Hrv˜DV™Hr+šôDV™Hr+šô.......DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB‰mRNA-1273-P301 mRNA-1273-P301-US321-2179US3212179US321USAB=YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV}DV™DV}Hrv˜DV™Hr+šôDV™Hr+šô.......DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB‰B‰mðmRNA-1273-P301 mRNA-1273-P301-US321-2180US3212180US321USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWODV}Hr~ÌDV™Hr+žDV™Hr+žDW%Hrä;¸DWOHsI DWOHsI .DW]DV}DWDW.DV}DW$DW%. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB‰mRNA-1273-P301 mRNA-1273-P301-US321-2180US3212180US321USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWODV}Hr~ÌDV™Hr+žDV™Hr+žDW%Hrä;¸DWOHsI DWOHsI .DW]DV}DWDW.DV}DW$DW%. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB‰B‰mðmRNA-1273-P301 mRNA-1273-P301-US321-2226US3212226US321USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDVŸDVHrDDVŸHr3‡ðDVŸHr3‡ð.......DW]DVDW+DW,.DVDW+DW,. Severe Obesity >=18 and <65 Years and at Risk A B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BLmRNA-1273-P301 mRNA-1273-P301-US321-2226US3212226US321USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDVŸDVHrDDVŸHr3‡ðDVŸHr3‡ð.......DW]DVDW+DW,.DVDW+DW,. Severe Obesity >=18 and <65 Years and at Risk A B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BLBLmômRNA-1273-P301 mRNA-1273-P301-US321-2226US3212226US321USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDVŸDVHrDDVŸHr3‡ðDVŸHr3‡ð.......DW]DVDW+DW,.DVDW+DW,. Severe Obesity >=18 and <65 Years and at Risk A B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BLmôBLÛèmRNA-1273-P301 mRNA-1273-P301-US321-2261US3212261US321USAB3YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDV¥DVƒHrTÐDV¥Hr;2ÔDV¥Hr;2Ô.......DW]DVƒDWLDWM.DVƒDWLDWM. Diabetes >=18 and <65 Years and at Risk A B¹Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‰mRNA-1273-P301 mRNA-1273-P301-US321-2261US3212261US321USAB3YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDV¥DVƒHrTÐDV¥Hr;2ÔDV¥Hr;2Ô.......DW]DVƒDWLDWM.DVƒDWLDWM. Diabetes >=18 and <65 Years and at Risk A B¹Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‰B‰mðmRNA-1273-P301 mRNA-1273-P301-US321-2261US3212261US321USAB3YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDV¥DVƒHrTÐDV¥Hr;2ÔDV¥Hr;2Ô.......DW]DVƒDWLDWM.DVƒDWLDWM. Diabetes >=18 and <65 Years and at Risk A B¹Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‰mðB‰ÛèmRNA-1273-P301 mRNA-1273-P301-US321-2269US3212269US321USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWLDVƒHr€¤DVHr0ØÀDVHr0ØÀDWLHsApDWLHsAp...DW]DVƒDWDDWE.DVƒDWKDWL. Severe Obesity >=18 and <65 Years and at Risk A BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB™mRNA-1273-P301 mRNA-1273-P301-US321-2269US3212269US321USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWLDVƒHr€¤DVHr0ØÀDVHr0ØÀDWLHsApDWLHsAp...DW]DVƒDWDDWE.DVƒDWKDWL. Severe Obesity >=18 and <65 Years and at Risk A BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB™B™mðmRNA-1273-P301 mRNA-1273-P301-US321-2281US3212281US321USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWFDV‡Hr®€DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B…mRNA-1273-P301 mRNA-1273-P301-US321-2281US3212281US321USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWFDV‡Hr®€DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B…B…mðmRNA-1273-P301 mRNA-1273-P301-US321-2281US3212281US321USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWFDV‡Hr®€DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B…mðB…ÛèmRNA-1273-P301 mRNA-1273-P301-US321-2281US3212281US321USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWFDV‡Hr®€DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B…ÛèB…IØmRNA-1273-P301 mRNA-1273-P301-US321-2296US3212296US321USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVˆDVªDVˆHrpDVªHrA³\DVªHrA³\.......DW]DVˆDW?DW@.DVˆDW?DW@. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BEmRNA-1273-P301 mRNA-1273-P301-US321-2302US3212302US321USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW\DVˆHr-DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B„mRNA-1273-P301 mRNA-1273-P301-US321-2336US3212336US321USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDVªDVHr\|DVªHrAÓDVªHrAÓ.......DW]DVDW>DW?.DVDW>DW?. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BÎmRNA-1273-P301 mRNA-1273-P301-US321-2396US3212396US321USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWGDV™Hr+¡ÀDV»HrXYDV»HrXYDWGHsýœDWGHsýœ...DW]DV™DWFDWG.DV™DWFDWG. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BwmRNA-1273-P301 mRNA-1273-P301-US322-2285US3222285US322USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWJDV…HrKôDV¡Hr68DV¡Hr68DWJHs»DDWJHs»D...DW]DV…DWIDWJ.DV…DWIDWJ. >=18 and <65 Years and Not at RiskAB½Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BzmRNA-1273-P301 mRNA-1273-P301-US322-2285US3222285US322USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWJDV…HrKôDV¡Hr68DV¡Hr68DWJHs»DDWJHs»D...DW]DV…DWIDWJ.DV…DWIDWJ. >=18 and <65 Years and Not at RiskAB½Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BzBzmômRNA-1273-P301 mRNA-1273-P301-US322-2285US3222285US322USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWJDV…HrKôDV¡Hr68DV¡Hr68DWJHs»DDWJHs»D...DW]DV…DWIDWJ.DV…DWIDWJ. >=18 and <65 Years and Not at RiskAB½Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BzmôBzÛèmRNA-1273-P301 mRNA-1273-P301-US322-2285US3222285US322USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWJDV…HrKôDV¡Hr68DV¡Hr68DWJHs»DDWJHs»D...DW]DV…DWIDWJ.DV…DWIDWJ. >=18 and <65 Years and Not at RiskAB½Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BzÛèBzIÜmRNA-1273-P301 mRNA-1273-P301-US322-2415US3222415US322USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŽDV®DVŽHräÈDV®HrFòÌDV®HrFòÌ.......DW]DVŽDWQDWR.DVŽDWQDWR. Diabetes >=18 and <65 Years and at Risk A B°Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB€mRNA-1273-P301 mRNA-1273-P301-US322-2415US3222415US322USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŽDV®DVŽHräÈDV®HrFòÌDV®HrFòÌ.......DW]DVŽDWQDWR.DVŽDWQDWR. Diabetes >=18 and <65 Years and at Risk A B°Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB€B€mðmRNA-1273-P301 mRNA-1273-P301-US322-2430US3222430US322USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWFDVHrÜDVHrE¸DVHrE¸DW)Hré'@DWFHsW€DWFHsW€.DW]DVDW(DW).DVDW(DW). >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B€mRNA-1273-P301 mRNA-1273-P301-US322-2430US3222430US322USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWFDVHrÜDVHrE¸DVHrE¸DW)Hré'@DWFHsW€DWFHsW€.DW]DVDW(DW).DVDW(DW). >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B€B€mðmRNA-1273-P301 mRNA-1273-P301-US322-2430US3222430US322USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWFDVHrÜDVHrE¸DVHrE¸DW)Hré'@DWFHsW€DWFHsW€.DW]DVDW(DW).DVDW(DW). >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B€mðB€ÛèmRNA-1273-P301 mRNA-1273-P301-US322-2450US3222450US322USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrbüDVHrE‘ DVHrE‘ DW*HrêzdDWKHsöDDWKHsöD.DW]DVDW)DW*.DVDW)DW*. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BemRNA-1273-P301 mRNA-1273-P301-US322-2450US3222450US322USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrbüDVHrE‘ DVHrE‘ DW*HrêzdDWKHsöDDWKHsöD.DW]DVDW)DW*.DVDW)DW*. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BeBemômRNA-1273-P301 mRNA-1273-P301-US322-2450US3222450US322USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrbüDVHrE‘ DVHrE‘ DW*HrêzdDWKHsöDDWKHsöD.DW]DVDW)DW*.DVDW)DW*. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BemôBeÛèmRNA-1273-P301 mRNA-1273-P301-US322-2450US3222450US322USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrbüDVHrE‘ DVHrE‘ DW*HrêzdDWKHsöDDWKHsöD.DW]DVDW)DW*.DVDW)DW*. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BeÛèBeIÜmRNA-1273-P301 mRNA-1273-P301-US322-2487US3222487US322USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWSDV’Hr!ùDVHrE0DVHrE0DW6HrúNDWSHs j DWSHs j .DW]DV’DW5DW6.DV’DW5DW6. >=65 Years A0B±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBƒmRNA-1273-P301 mRNA-1273-P301-US322-2487US3222487US322USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWSDV’Hr!ùDVHrE0DVHrE0DW6HrúNDWSHs j DWSHs j .DW]DV’DW5DW6.DV’DW5DW6. >=65 Years A0B±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBƒBƒmðmRNA-1273-P301 mRNA-1273-P301-US322-2545US3222545US322USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV•DWIDV•Hr%öøDV²HrLIpDV²HrLIpDWIHs[<DWIHs[<...DW]DV•DWHDWI.DV•DWHDWI. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BxmRNA-1273-P301 mRNA-1273-P301-US322-2610US3222610US322USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWMDVŸHr3 XDVÂHra5ØDVÂHra5ØDWMHs‰ÌDWMHs‰Ì...DW]DVŸDWLDWM.DVŸDWLDWM. >=18 and <65 Years and Not at RiskABœMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B’mRNA-1273-P301 mRNA-1273-P301-US322-2610US3222610US322USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWMDVŸHr3 XDVÂHra5ØDVÂHra5ØDWMHs‰ÌDWMHs‰Ì...DW]DVŸDWLDWM.DVŸDWLDWM. >=18 and <65 Years and Not at RiskABœMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B’B’mðmRNA-1273-P301 mRNA-1273-P301-US322-2610US3222610US322USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWMDVŸHr3 XDVÂHra5ØDVÂHra5ØDWMHs‰ÌDWMHs‰Ì...DW]DVŸDWLDWM.DVŸDWLDWM. >=18 and <65 Years and Not at RiskABœMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B’mðB’ÛèmRNA-1273-P301 mRNA-1273-P301-US322-2657US3222657US322USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNNYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVDVÊDVHrEØØDVÊHrkì¼DVÊHrkì¼.......DW]DVDW+DW,DW,DVDW+DW,DW, >=65 Years A0BcMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BXmRNA-1273-P301 mRNA-1273-P301-US323-2028US3232028US323USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW1DV{Hr°pDV—Hr( DV—Hr( DWHrÎà8DW1Hró¿èDW1Hró¿è.DW]DV{DWDW.DV{DWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BgmRNA-1273-P301 mRNA-1273-P301-US323-2028US3232028US323USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW1DV{Hr°pDV—Hr( DV—Hr( DWHrÎà8DW1Hró¿èDW1Hró¿è.DW]DV{DWDW.DV{DWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BgBgmômRNA-1273-P301 mRNA-1273-P301-US323-2028US3232028US323USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW1DV{Hr°pDV—Hr( DV—Hr( DWHrÎà8DW1Hró¿èDW1Hró¿è.DW]DV{DWDW.DV{DWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BgmôBgÛèmRNA-1273-P301 mRNA-1273-P301-US323-2028US3232028US323USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW1DV{Hr°pDV—Hr( DV—Hr( DWHrÎà8DW1Hró¿èDW1Hró¿è.DW]DV{DWDW.DV{DWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BgÛèBgIÜmRNA-1273-P301 mRNA-1273-P301-US323-2103US3232103US323USAB+YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW+DVˆHrDV¤Hr:€DV¤Hr:€DWHrÆóxDW+HrëÉÈDW+HrëÉÈ.DW]DVˆDWDW.DVˆDWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A BºNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B7mRNA-1273-P301 mRNA-1273-P301-US323-2145US3232145US323USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DWHDV‘Hr Ë8DVHrE™DVHrE™DW,Hrí¼DWHHsðDWHHsð.DW]DV‘DW+DW,.DV‘DW+DW,. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B mRNA-1273-P301 mRNA-1273-P301-US323-2157US3232157US323USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW2DV—Hr(ÜDV³HrM´DV³HrM´DW2HrôíDW2Hrôí...DW]DV—DW1DW2.DV—DW1DW2. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BymRNA-1273-P301 mRNA-1273-P301-US323-2157US3232157US323USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW2DV—Hr(ÜDV³HrM´DV³HrM´DW2HrôíDW2Hrôí...DW]DV—DW1DW2.DV—DW1DW2. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score ByBymômRNA-1273-P301 mRNA-1273-P301-US323-2157US3232157US323USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW2DV—Hr(ÜDV³HrM´DV³HrM´DW2HrôíDW2Hrôí...DW]DV—DW1DW2.DV—DW1DW2. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BymôByÛèmRNA-1273-P301 mRNA-1273-P301-US323-2157US3232157US323USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW2DV—Hr(ÜDV³HrM´DV³HrM´DW2HrôíDW2Hrôí...DW]DV—DW1DW2.DV—DW1DW2. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score ByÛèByIÜmRNA-1273-P301 mRNA-1273-P301-US324-2003US3242003US324USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDWGDVuHqûß”DV’Hr" @DV’Hr" @DWGHsÃôDWGHsÃô...DW]DVuDWFDWG.DVuDWFDWG. Severe Obesity >=65 Years A0BÌNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BèmRNA-1273-P301 mRNA-1273-P301-US324-2047US3242047US324USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDW?DVwHqþ®hDV˜Hr*:ìDV˜Hr*:ìDW#HráŽàDW?Hs]tDW?Hs]t.DW]DVwDW"DW#.DVwDW"DW#. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBŽmRNA-1273-P301 mRNA-1273-P301-US324-2047US3242047US324USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDW?DVwHqþ®hDV˜Hr*:ìDV˜Hr*:ìDW#HráŽàDW?Hs]tDW?Hs]t.DW]DVwDW"DW#.DVwDW"DW#. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBŽBŽmðmRNA-1273-P301 mRNA-1273-P301-US324-2089US3242089US324USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW>DV}Hr†ÄDV™Hr+‚XDV™Hr+‚XDW!HrÞýìDW>HsDW>Hs.DW]DV}DW DW!DWGDV}DW DW!DWG >=18 and <65 Years and Not at RiskAB¯Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BRmRNA-1273-P301 mRNA-1273-P301-US324-2112US3242112US324USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW=DV€Hr pôDVHr0¬8DVHr0¬8DW"HrßòœDW=Hs~8DW=Hs~8.DW]DV€DW!DW".DV€DW!DW". >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BImRNA-1273-P301 mRNA-1273-P301-US324-2127US3242127US324USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWDDVHrlDVžHr1Î$DVžHr1Î$DW(HrçÔÐDWDHs·ÈDWDHs·È.DW]DVDW'DW(.DVDW'DW(. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BhmRNA-1273-P301 mRNA-1273-P301-US324-2127US3242127US324USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWDDVHrlDVžHr1Î$DVžHr1Î$DW(HrçÔÐDWDHs·ÈDWDHs·È.DW]DVDW'DW(.DVDW'DW(. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BhBhmômRNA-1273-P301 mRNA-1273-P301-US324-2127US3242127US324USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWDDVHrlDVžHr1Î$DVžHr1Î$DW(HrçÔÐDWDHs·ÈDWDHs·È.DW]DVDW'DW(.DVDW'DW(. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BhmôBhÛèmRNA-1273-P301 mRNA-1273-P301-US324-2153US3242153US324USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW0DV‚Hr JDVŸHr3[,DVŸHr3[,DWHrÍ¡ðDW0HròFDW0HròF.DW]DV‚DWDW.DV‚DWDW. Significant Cardiac DiseaseSevere ObesityDiabetes >=65 Years A0B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BomRNA-1273-P301 mRNA-1273-P301-US324-2153US3242153US324USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW0DV‚Hr JDVŸHr3[,DVŸHr3[,DWHrÍ¡ðDW0HròFDW0HròF.DW]DV‚DWDW.DV‚DWDW. Significant Cardiac DiseaseSevere ObesityDiabetes >=65 Years A0B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BoBomômRNA-1273-P301 mRNA-1273-P301-US324-2153US3242153US324USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW0DV‚Hr JDVŸHr3[,DVŸHr3[,DWHrÍ¡ðDW0HròFDW0HròF.DW]DV‚DWDW.DV‚DWDW. Significant Cardiac DiseaseSevere ObesityDiabetes >=65 Years A0B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BomôBoÛèmRNA-1273-P301 mRNA-1273-P301-US324-2153US3242153US324USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW0DV‚Hr JDVŸHr3[,DVŸHr3[,DWHrÍ¡ðDW0HròFDW0HròF.DW]DV‚DWDW.DV‚DWDW. Significant Cardiac DiseaseSevere ObesityDiabetes >=65 Years A0B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BoÛèBoIÜmRNA-1273-P301 mRNA-1273-P301-US324-2163US3242163US324USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVƒDV DVƒHrrÐDV Hr4‘ôDV Hr4‘ô.......DW]DVƒDW(DW).DVƒDW(DW). >=65 Years A0B¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‰mRNA-1273-P301 mRNA-1273-P301-US324-2226US3242226US324USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW7DV‰HrPDV¦Hr<½DV¦Hr<½DWHr×DW7Hrûã€DW7Hrûã€.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBjmRNA-1273-P301 mRNA-1273-P301-US324-2226US3242226US324USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW7DV‰HrPDV¦Hr<½DV¦Hr<½DWHr×DW7Hrûã€DW7Hrûã€.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBjBjmômRNA-1273-P301 mRNA-1273-P301-US324-2230US3242230US324USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW0DVŠHrƒ\DV§Hr=©LDV§Hr=©LDWHrÎº|DW0HròH¬DW0HròH¬.DW]DVŠDWDW.DVŠDWDW. Significant Cardiac Disease Diabetes >=65 Years A0B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BKmRNA-1273-P301 mRNA-1273-P301-US324-2276US3242276US324USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW[DVHreDVHrEš€DVHrEš€DW@Hs¡\DW[Hs*ø<DW[Hs*ø<.DW]DVDW?DW@.DVDW?DW@. >=18 and <65 Years and Not at RiskAB±Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B”mRNA-1273-P301 mRNA-1273-P301-US324-2384US3242384US324USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV§DW(DV§Hr=ä˜DVÆHrf©ŒDVÆHrf©ŒDWHrÅ›¤DW(HrçÃðDW(HrçÃð.DW]DV§DW DW.DV§DW DW. >=18 and <65 Years and Not at RiskAB˜Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BLmRNA-1273-P301 mRNA-1273-P301-US324-2397US3242397US324USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DW1DV«HrC=”DVÇHrh(DVÇHrh(DWHrÏ`DW1HróÉÀDW1HróÉÀ.DW]DV«DWDW.DV«DWDW. >=18 and <65 Years and Not at RiskAB—Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B%mRNA-1273-P301 mRNA-1273-P301-US324-2397US3242397US324USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DW1DV«HrC=”DVÇHrh(DVÇHrh(DWHrÏ`DW1HróÉÀDW1HróÉÀ.DW]DV«DWDW.DV«DWDW. >=18 and <65 Years and Not at RiskAB—Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B%B%mômRNA-1273-P301 mRNA-1273-P301-US324-2397US3242397US324USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DW1DV«HrC=”DVÇHrh(DVÇHrh(DWHrÏ`DW1HróÉÀDW1HróÉÀ.DW]DV«DWDW.DV«DWDW. >=18 and <65 Years and Not at RiskAB—Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B%môB%ÛæmRNA-1273-P301 mRNA-1273-P301-US324-2398US3242398US324USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DW[DV«HrCTŒDVÉHrjÓôDVÉHrjÓôDW=Hs’ØDW[Hs+YDDW[Hs+YD.DW]DV«DW<DW=.DV«DW<DW=. Severe Obesity >=18 and <65 Years and at Risk A B•Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBpmRNA-1273-P301 mRNA-1273-P301-US324-2398US3242398US324USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV«DW[DV«HrCTŒDVÉHrjÓôDVÉHrjÓôDW=Hs’ØDW[Hs+YDDW[Hs+YD.DW]DV«DW<DW=.DV«DW<DW=. Severe Obesity >=18 and <65 Years and at Risk A B•Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBpBpmômRNA-1273-P301 mRNA-1273-P301-US325-2083US3252083US325USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDW,DVwHqþo\DV’Hr"+|DV’Hr"+|DWHrÉ§DW,Hrí_DW,Hrí_.DW]DVwDWDW.DVwDWDW. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BImRNA-1273-P301 mRNA-1273-P301-US325-2083US3252083US325USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDW,DVwHqþo\DV’Hr"+|DV’Hr"+|DWHrÉ§DW,Hrí_DW,Hrí_.DW]DVwDWDW.DVwDWDW. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BIBImômRNA-1273-P301 mRNA-1273-P301-US325-2083US3252083US325USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDW,DVwHqþo\DV’Hr"+|DV’Hr"+|DWHrÉ§DW,Hrí_DW,Hrí_.DW]DVwDWDW.DVwDWDW. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BImôBIÛèmRNA-1273-P301 mRNA-1273-P301-US325-2202US3252202US325USAB2YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWGDV~HråÜDV Hr4ÙpDV Hr4ÙpDWGHs DWGHs ...DW]DV~DW?DW@.DV~DWFDWG. Diabetes >=18 and <65 Years and at Risk A B¾Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BžmRNA-1273-P301 mRNA-1273-P301-US325-2202US3252202US325USAB2YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWGDV~HråÜDV Hr4ÙpDV Hr4ÙpDWGHs DWGHs ...DW]DV~DW?DW@.DV~DWFDWG. Diabetes >=18 and <65 Years and at Risk A B¾Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BžBžmðmRNA-1273-P301 mRNA-1273-P301-US325-2202US3252202US325USAB2YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWGDV~HråÜDV Hr4ÙpDV Hr4ÙpDWGHs DWGHs ...DW]DV~DW?DW@.DV~DWFDWG. Diabetes >=18 and <65 Years and at Risk A B¾Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BžmðBžÛèmRNA-1273-P301 mRNA-1273-P301-US325-2211US3252211US325USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWADV€Hr i°DVœHr/nhDVœHr/nhDW$HrâñDWAHsùäDWAHsùä.DW]DV€DW#DW$.DV€DW#DW$. >=18 and <65 Years and Not at RiskABÂMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B.mRNA-1273-P301 mRNA-1273-P301-US325-2211US3252211US325USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWADV€Hr i°DVœHr/nhDVœHr/nhDW$HrâñDWAHsùäDWAHsùä.DW]DV€DW#DW$.DV€DW#DW$. >=18 and <65 Years and Not at RiskABÂMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B.B.mômRNA-1273-P301 mRNA-1273-P301-US325-2211US3252211US325USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWADV€Hr i°DVœHr/nhDVœHr/nhDW$HrâñDWAHsùäDWAHsùä.DW]DV€DW#DW$.DV€DW#DW$. >=18 and <65 Years and Not at RiskABÂMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B.môB.ÛæmRNA-1273-P301 mRNA-1273-P301-US325-2212US3252212US325USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV€DVžDV€Hr ‹èDVžHr1¾èDVžHr1¾è......DVôDVôDV€DW'DW(DW)DV€DW'DW(DW) Severe Obesity >=18 and <65 Years and at Risk A BŒMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B,mRNA-1273-P301 mRNA-1273-P301-US325-2212US3252212US325USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV€DVžDV€Hr ‹èDVžHr1¾èDVžHr1¾è......DVôDVôDV€DW'DW(DW)DV€DW'DW(DW) Severe Obesity >=18 and <65 Years and at Risk A BŒMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B,B,mômRNA-1273-P301 mRNA-1273-P301-US325-2212US3252212US325USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV€DVžDV€Hr ‹èDVžHr1¾èDVžHr1¾è......DVôDVôDV€DW'DW(DW)DV€DW'DW(DW) Severe Obesity >=18 and <65 Years and at Risk A BŒMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B,môB,ÛæmRNA-1273-P301 mRNA-1273-P301-US325-2212US3252212US325USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV€DVžDV€Hr ‹èDVžHr1¾èDVžHr1¾è......DVôDVôDV€DW'DW(DW)DV€DW'DW(DW) Severe Obesity >=18 and <65 Years and at Risk A BŒMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B,ÛæB,IÚmRNA-1273-P301 mRNA-1273-P301-US325-2304US3252304US325USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWODV…HrDV¡Hr5û˜DV¡Hr5û˜DWOHs>`DWOHs>`...DW]DV…DWNDWO.DV…DWNDWO. >=18 and <65 Years and Not at RiskAB½Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B‹mRNA-1273-P301 mRNA-1273-P301-US325-2304US3252304US325USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWODV…HrDV¡Hr5û˜DV¡Hr5û˜DWOHs>`DWOHs>`...DW]DV…DWNDWO.DV…DWNDWO. >=18 and <65 Years and Not at RiskAB½Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B‹B‹mðmRNA-1273-P301 mRNA-1273-P301-US325-2304US3252304US325USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWODV…HrDV¡Hr5û˜DV¡Hr5û˜DWOHs>`DWOHs>`...DW]DV…DWNDWO.DV…DWNDWO. >=18 and <65 Years and Not at RiskAB½Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B‹mðB‹ÛèmRNA-1273-P301 mRNA-1273-P301-US325-2304US3252304US325USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWODV…HrDV¡Hr5û˜DV¡Hr5û˜DWOHs>`DWOHs>`...DW]DV…DWNDWO.DV…DWNDWO. >=18 and <65 Years and Not at RiskAB½Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B‹ÛèB‹IØmRNA-1273-P301 mRNA-1273-P301-US325-2334US3252334US325USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWEDVˆHr,DV¥Hr;R´DV¥Hr;R´DW)Hréa`DWEHsALDWEHsAL.DW]DVˆDW(DW).DVˆDW(DW). >=18 and <65 Years and Not at RiskAB¹Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB\mRNA-1273-P301 mRNA-1273-P301-US325-2334US3252334US325USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWEDVˆHr,DV¥Hr;R´DV¥Hr;R´DW)Hréa`DWEHsALDWEHsAL.DW]DVˆDW(DW).DVˆDW(DW). >=18 and <65 Years and Not at RiskAB¹Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB\B\mômRNA-1273-P301 mRNA-1273-P301-US325-2388US3252388US325USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŒDWBDVŒHrX„DV«HrBâàDV«HrBâàDWBHs I„DWBHs I„...DW]DVŒDWADWB.DVŒDWADWB. >=18 and <65 Years and Not at RiskAB³Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BˆmRNA-1273-P301 mRNA-1273-P301-US325-2388US3252388US325USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŒDWBDVŒHrX„DV«HrBâàDV«HrBâàDWBHs I„DWBHs I„...DW]DVŒDWADWB.DVŒDWADWB. >=18 and <65 Years and Not at RiskAB³Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BˆBˆmðmRNA-1273-P301 mRNA-1273-P301-US325-2388US3252388US325USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŒDWBDVŒHrX„DV«HrBâàDV«HrBâàDWBHs I„DWBHs I„...DW]DVŒDWADWB.DVŒDWADWB. >=18 and <65 Years and Not at RiskAB³Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BˆmðBˆÛèmRNA-1273-P301 mRNA-1273-P301-US325-2455US3252455US325USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWHDV˜Hr*+ìDVµHrPJ\DVµHrPJ\DWHHsóDWHHsó...DW]DV˜DWGDWH.DV˜DWGDWH. >=18 and <65 Years and Not at RiskAB©Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B…mRNA-1273-P301 mRNA-1273-P301-US325-2602US3252602US325USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWODV®HrFÿìDVÊHrkØXDVÊHrkØXDW3Hröe|DWOHsNDWOHsN.DW]DV®DW2DW3.DV®DW2DW3. >=18 and <65 Years and Not at RiskAB”Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BCmRNA-1273-P301 mRNA-1273-P301-US325-2602US3252602US325USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWODV®HrFÿìDVÊHrkØXDVÊHrkØXDW3Hröe|DWOHsNDWOHsN.DW]DV®DW2DW3.DV®DW2DW3. >=18 and <65 Years and Not at RiskAB”Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BCBCmômRNA-1273-P301 mRNA-1273-P301-US325-2602US3252602US325USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWODV®HrFÿìDVÊHrkØXDVÊHrkØXDW3Hröe|DWOHsNDWOHsN.DW]DV®DW2DW3.DV®DW2DW3. >=18 and <65 Years and Not at RiskAB”Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BCmôBCÛèmRNA-1273-P301 mRNA-1273-P301-US325-2602US3252602US325USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWODV®HrFÿìDVÊHrkØXDVÊHrkØXDW3Hröe|DWOHsNDWOHsN.DW]DV®DW2DW3.DV®DW2DW3. >=18 and <65 Years and Not at RiskAB”Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BCÛèBCIÜmRNA-1273-P301 mRNA-1273-P301-US325-2642US3252642US325USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DWODV³HrMã˜DVÐHrtˆDVÐHrtˆDW4Hr÷¸dDWOHsˆèDWOHsˆè.DW]DV³DW3DW4.DV³DW3DW4. >=18 and <65 Years and Not at RiskABŽMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BTmRNA-1273-P301 mRNA-1273-P301-US325-2659US3252659US325USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DW0DV¹HrUªœDVÕHrz™DVÕHrz™DWHrÍ…XDW0Hrò‡¸DW0Hrò‡¸.DW]DV¹DWDW.DV¹DWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B*mRNA-1273-P301 mRNA-1273-P301-US325-2659US3252659US325USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DW0DV¹HrUªœDVÕHrz™DVÕHrz™DWHrÍ…XDW0Hrò‡¸DW0Hrò‡¸.DW]DV¹DWDW.DV¹DWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B*B*mômRNA-1273-P301 mRNA-1273-P301-US325-2659US3252659US325USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DW0DV¹HrUªœDVÕHrz™DVÕHrz™DWHrÍ…XDW0Hrò‡¸DW0Hrò‡¸.DW]DV¹DWDW.DV¹DWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B*môB*ÛæmRNA-1273-P301 mRNA-1273-P301-US325-2678US3252678US325USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV¼DVØDV¼HrYqhDVØHr~¡|DVØHr~¡|.......DW]DV¼DWGDWH.DV¼DWGDWH. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B>mRNA-1273-P301 mRNA-1273-P301-US325-2700US3252700US325USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDWODVÃHrb¨ÜDVßHr‡¨lDVßHr‡¨lDWOHs=èDWOHs=è...DW]DVÃDWNDWO.DVÃDWNDWO. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BJmRNA-1273-P301 mRNA-1273-P301-US325-2700US3252700US325USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDWODVÃHrb¨ÜDVßHr‡¨lDVßHr‡¨lDWOHs=èDWOHs=è...DW]DVÃDWNDWO.DVÃDWNDWO. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BJBJmômRNA-1273-P301 mRNA-1273-P301-US325-2700US3252700US325USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDWODVÃHrb¨ÜDVßHr‡¨lDVßHr‡¨lDWOHs=èDWOHs=è...DW]DVÃDWNDWO.DVÃDWNDWO. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BJmôBJÛèmRNA-1273-P301 mRNA-1273-P301-US326-2007US3262007US326USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWNDVkHqîôPDVˆHrèDVˆHrèDWNHså`DWNHså`...DW]DVkDWMDWN.DVkDWMDWN. Diabetes >=18 and <65 Years and at Risk A BÖMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B~mRNA-1273-P301 mRNA-1273-P301-US326-2007US3262007US326USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWNDVkHqîôPDVˆHrèDVˆHrèDWNHså`DWNHså`...DW]DVkDWMDWN.DVkDWMDWN. Diabetes >=18 and <65 Years and at Risk A BÖMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B~B~mômRNA-1273-P301 mRNA-1273-P301-US326-2007US3262007US326USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWNDVkHqîôPDVˆHrèDVˆHrèDWNHså`DWNHså`...DW]DVkDWMDWN.DVkDWMDWN. Diabetes >=18 and <65 Years and at Risk A BÖMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B~môB~ÛèmRNA-1273-P301 mRNA-1273-P301-US326-2054US3262054US326USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDWLDVnHqòÌ8DVHrXDVHrXDWLHs:àDWLHs:à...DW]DVnDWKDWL.DVnDWKDWL. >=18 and <65 Years and Not at RiskABÏMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B³mRNA-1273-P301 mRNA-1273-P301-US326-2099US3262099US326USAB=YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWYDVtHqú¬ÈDV‘Hr ãÔDV‘Hr ãÔDW7Hrû DWYHs(^ØDWYHs(^Ø.DW]DVtDW6DW7.DVtDW6DW7. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÍNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BDmRNA-1273-P301 mRNA-1273-P301-US326-2099US3262099US326USAB=YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWYDVtHqú¬ÈDV‘Hr ãÔDV‘Hr ãÔDW7Hrû DWYHs(^ØDWYHs(^Ø.DW]DVtDW6DW7.DVtDW6DW7. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÍNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BDBDmômRNA-1273-P301 mRNA-1273-P301-US326-2099US3262099US326USAB=YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWYDVtHqú¬ÈDV‘Hr ãÔDV‘Hr ãÔDW7Hrû DWYHs(^ØDWYHs(^Ø.DW]DVtDW6DW7.DVtDW6DW7. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÍNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BDmôBDÛèmRNA-1273-P301 mRNA-1273-P301-US326-2099US3262099US326USAB=YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWYDVtHqú¬ÈDV‘Hr ãÔDV‘Hr ãÔDW7Hrû DWYHs(^ØDWYHs(^Ø.DW]DVtDW6DW7.DVtDW6DW7. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÍNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BDÛèBDIÜmRNA-1273-P301 mRNA-1273-P301-US326-2275US3262275US326USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVµDWMDVµHrP<ˆDVÕHrz8DVÕHrz8DWMHs{€DWMHs{€...DW]DVµDWLDWM.DVµDWLDWM. Significant Cardiac Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BomRNA-1273-P301 mRNA-1273-P301-US326-2275US3262275US326USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVµDWMDVµHrP<ˆDVÕHrz8DVÕHrz8DWMHs{€DWMHs{€...DW]DVµDWLDWM.DVµDWLDWM. Significant Cardiac Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BoBomômRNA-1273-P301 mRNA-1273-P301-US326-2275US3262275US326USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVµDWMDVµHrP<ˆDVÕHrz8DVÕHrz8DWMHs{€DWMHs{€...DW]DVµDWLDWM.DVµDWLDWM. Significant Cardiac Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BomôBoÛèmRNA-1273-P301 mRNA-1273-P301-US326-2275US3262275US326USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVµDWMDVµHrP<ˆDVÕHrz8DVÕHrz8DWMHs{€DWMHs{€...DW]DVµDWLDWM.DVµDWLDWM. Significant Cardiac Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BoÛèBoIÜmRNA-1273-P301 mRNA-1273-P301-US327-2010US3272010US327USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDWODVmHqñ«DV‹Hr#ØDV‹Hr#ØDW0Hrò©´DWOHsvdDWOHsvd.DW]DVmDW/DW0.DVmDW/DW0. >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBrmRNA-1273-P301 mRNA-1273-P301-US327-2010US3272010US327USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDWODVmHqñ«DV‹Hr#ØDV‹Hr#ØDW0Hrò©´DWOHsvdDWOHsvd.DW]DVmDW/DW0.DVmDW/DW0. >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBrBrmômRNA-1273-P301 mRNA-1273-P301-US327-2021US3272021US327USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDWBDVnHqòò0DVHr3<DVHr3<DWBHs D DWBHs D ...DW]DVnDWADWB.DVnDWADWB. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B˜mRNA-1273-P301 mRNA-1273-P301-US327-2021US3272021US327USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDWBDVnHqòò0DVHr3<DVHr3<DWBHs D DWBHs D ...DW]DVnDWADWB.DVnDWADWB. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B˜B˜mðmRNA-1273-P301 mRNA-1273-P301-US327-2021US3272021US327USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDWBDVnHqòò0DVHr3<DVHr3<DWBHs D DWBHs D ...DW]DVnDWADWB.DVnDWADWB. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B˜mðB˜ÛèmRNA-1273-P301 mRNA-1273-P301-US327-2021US3272021US327USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDWBDVnHqòò0DVHr3<DVHr3<DWBHs D DWBHs D ...DW]DVnDWADWB.DVnDWADWB. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B˜ÛèB˜IØmRNA-1273-P301 mRNA-1273-P301-US327-2055US3272055US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDV‘DVtHqúÔdDV‘Hr ÍDV‘Hr Í......DWDWDVtDW6..DVtDW6.. >=18 and <65 Years and Not at RiskAB¦Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B=mRNA-1273-P301 mRNA-1273-P301-US327-2055US3272055US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDV‘DVtHqúÔdDV‘Hr ÍDV‘Hr Í......DWDWDVtDW6..DVtDW6.. >=18 and <65 Years and Not at RiskAB¦Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B=B=mômRNA-1273-P301 mRNA-1273-P301-US327-2055US3272055US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDV‘DVtHqúÔdDV‘Hr ÍDV‘Hr Í......DWDWDVtDW6..DVtDW6.. >=18 and <65 Years and Not at RiskAB¦Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B=môB=ÛæmRNA-1273-P301 mRNA-1273-P301-US327-2097US3272097US327USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW7DVyHr|DV—Hr(À,DV—Hr(À,DWHrÐèDW7HrûLDW7HrûL.DW]DVyDWDW.DVyDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BfmRNA-1273-P301 mRNA-1273-P301-US327-2097US3272097US327USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW7DVyHr|DV—Hr(À,DV—Hr(À,DWHrÐèDW7HrûLDW7HrûL.DW]DVyDWDW.DVyDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BfBfmômRNA-1273-P301 mRNA-1273-P301-US327-2097US3272097US327USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW7DVyHr|DV—Hr(À,DV—Hr(À,DWHrÐèDW7HrûLDW7HrûL.DW]DVyDWDW.DVyDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BfmôBfÛèmRNA-1273-P301 mRNA-1273-P301-US327-2097US3272097US327USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW7DVyHr|DV—Hr(À,DV—Hr(À,DWHrÐèDW7HrûLDW7HrûL.DW]DVyDWDW.DVyDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BfÛèBfIÜmRNA-1273-P301 mRNA-1273-P301-US327-2104US3272104US327USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWPDVzHr°DV–Hr'†DV–Hr'†DWPHs¹˜DWPHs¹˜...DW]DVzDWODWP.DVzDWODWP.Chronic Lung DiseaseSignificant Cardiac Disease Diabetes >=65 Years A0BÈNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B’mRNA-1273-P301 mRNA-1273-P301-US327-2104US3272104US327USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWPDVzHr°DV–Hr'†DV–Hr'†DWPHs¹˜DWPHs¹˜...DW]DVzDWODWP.DVzDWODWP.Chronic Lung DiseaseSignificant Cardiac Disease Diabetes >=65 Years A0BÈNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B’B’mðmRNA-1273-P301 mRNA-1273-P301-US327-2104US3272104US327USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWPDVzHr°DV–Hr'†DV–Hr'†DWPHs¹˜DWPHs¹˜...DW]DVzDWODWP.DVzDWODWP.Chronic Lung DiseaseSignificant Cardiac Disease Diabetes >=65 Years A0BÈNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B’mðB’ÛèmRNA-1273-P301 mRNA-1273-P301-US327-2104US3272104US327USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWPDVzHr°DV–Hr'†DV–Hr'†DWPHs¹˜DWPHs¹˜...DW]DVzDWODWP.DVzDWODWP.Chronic Lung DiseaseSignificant Cardiac Disease Diabetes >=65 Years A0BÈNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B’ÛèB’IØmRNA-1273-P301 mRNA-1273-P301-US327-2142US3272142US327USAB7YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW1DV}HrX\DVHr0ÜDVHr0ÜDWHrÆÉ„DW1Hró¿èDW1Hró¿è.DW]DV}DWDW.DV}DWDW. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BMmRNA-1273-P301 mRNA-1273-P301-US327-2142US3272142US327USAB7YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW1DV}HrX\DVHr0ÜDVHr0ÜDWHrÆÉ„DW1Hró¿èDW1Hró¿è.DW]DV}DWDW.DV}DWDW. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BMBMmômRNA-1273-P301 mRNA-1273-P301-US327-2142US3272142US327USAB7YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW1DV}HrX\DVHr0ÜDVHr0ÜDWHrÆÉ„DW1Hró¿èDW1Hró¿è.DW]DV}DWDW.DV}DWDW. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BMmôBMÛèmRNA-1273-P301 mRNA-1273-P301-US327-2174US3272174US327USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW(DV€Hr sˆDVœHr/oDVœHr/oDWHr½ÈèDW(HrçÕüDW(HrçÕü.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BQmRNA-1273-P301 mRNA-1273-P301-US327-2174US3272174US327USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW(DV€Hr sˆDVœHr/oDVœHr/oDWHr½ÈèDW(HrçÕüDW(HrçÕü.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BQBQmômRNA-1273-P301 mRNA-1273-P301-US327-2174US3272174US327USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW(DV€Hr sˆDVœHr/oDVœHr/oDWHr½ÈèDW(HrçÕüDW(HrçÕü.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BQmôBQÛèmRNA-1273-P301 mRNA-1273-P301-US327-2184US3272184US327USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW+DV‚Hrý8DVžHr1ÞÈDVžHr1ÞÈDWHr½ÖDDW+HrìœDW+Hrìœ.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BHmRNA-1273-P301 mRNA-1273-P301-US327-2184US3272184US327USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW+DV‚Hrý8DVžHr1ÞÈDVžHr1ÞÈDWHr½ÖDDW+HrìœDW+Hrìœ.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BHBHmômRNA-1273-P301 mRNA-1273-P301-US327-2184US3272184US327USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW+DV‚Hrý8DVžHr1ÞÈDVžHr1ÞÈDWHr½ÖDDW+HrìœDW+Hrìœ.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BHmôBHÛèmRNA-1273-P301 mRNA-1273-P301-US327-2184US3272184US327USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW+DV‚Hrý8DVžHr1ÞÈDVžHr1ÞÈDWHr½ÖDDW+HrìœDW+Hrìœ.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BHÛèBHIÜmRNA-1273-P301 mRNA-1273-P301-US327-2186US3272186US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW[DV‚Hr DVŸHr3~TDVŸHr3~TDW2HrõiÄDW[Hs+OäDW[Hs+Oä.DW]DV‚DW1DW2.DV‚DW1DW2. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BLmRNA-1273-P301 mRNA-1273-P301-US327-2186US3272186US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW[DV‚Hr DVŸHr3~TDVŸHr3~TDW2HrõiÄDW[Hs+OäDW[Hs+Oä.DW]DV‚DW1DW2.DV‚DW1DW2. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BLBLmômRNA-1273-P301 mRNA-1273-P301-US327-2186US3272186US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW[DV‚Hr DVŸHr3~TDVŸHr3~TDW2HrõiÄDW[Hs+OäDW[Hs+Oä.DW]DV‚DW1DW2.DV‚DW1DW2. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BLmôBLÛèmRNA-1273-P301 mRNA-1273-P301-US327-2186US3272186US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW[DV‚Hr DVŸHr3~TDVŸHr3~TDW2HrõiÄDW[Hs+OäDW[Hs+Oä.DW]DV‚DW1DW2.DV‚DW1DW2. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BLÛèBLIÜmRNA-1273-P301 mRNA-1273-P301-US327-2188US3272188US327USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWEDV‚Hr DVžHr1õHDVžHr1õHDW)Hréo¬DWEHs\¸DWEHs\¸.DW]DV‚DW(DW).DV‚DW(DW). >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BwmRNA-1273-P301 mRNA-1273-P301-US327-2196US3272196US327USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW0DV‚Hr ||DVžHr27`DVžHr27`DWHrÐutDW0Hrò±4DW0Hrò±4.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BRmRNA-1273-P301 mRNA-1273-P301-US327-2196US3272196US327USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW0DV‚Hr ||DVžHr27`DVžHr27`DWHrÐutDW0Hrò±4DW0Hrò±4.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BRBRmômRNA-1273-P301 mRNA-1273-P301-US327-2196US3272196US327USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW0DV‚Hr ||DVžHr27`DVžHr27`DWHrÐutDW0Hrò±4DW0Hrò±4.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BRmôBRÛèmRNA-1273-P301 mRNA-1273-P301-US327-2196US3272196US327USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW0DV‚Hr ||DVžHr27`DVžHr27`DWHrÐutDW0Hrò±4DW0Hrò±4.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BRÛèBRIÜmRNA-1273-P301 mRNA-1273-P301-US327-2219US3272219US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW2DVƒHrÂDDVŸHr3‡´DVŸHr3‡´DW2Hrôó,DW2Hrôó,...DW]DVƒDW1DW2.DVƒDW1DW2. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B=mRNA-1273-P301 mRNA-1273-P301-US327-2219US3272219US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW2DVƒHrÂDDVŸHr3‡´DVŸHr3‡´DW2Hrôó,DW2Hrôó,...DW]DVƒDW1DW2.DVƒDW1DW2. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B=B=mômRNA-1273-P301 mRNA-1273-P301-US327-2219US3272219US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW2DVƒHrÂDDVŸHr3‡´DVŸHr3‡´DW2Hrôó,DW2Hrôó,...DW]DVƒDW1DW2.DVƒDW1DW2. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B=môB=ÛæmRNA-1273-P301 mRNA-1273-P301-US327-2219US3272219US327USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW2DVƒHrÂDDVŸHr3‡´DVŸHr3‡´DW2Hrôó,DW2Hrôó,...DW]DVƒDW1DW2.DVƒDW1DW2. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B=ÛæB=IÚmRNA-1273-P301 mRNA-1273-P301-US327-2271US3272271US327USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DW6DV…HrDV¤Hr: DV¤Hr: DWHr×HDW6HrúJüDW6HrúJü.DW]DV…DWDW.DV…DWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BCmRNA-1273-P301 mRNA-1273-P301-US327-2271US3272271US327USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DW6DV…HrDV¤Hr: DV¤Hr: DWHr×HDW6HrúJüDW6HrúJü.DW]DV…DWDW.DV…DWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BCBCmômRNA-1273-P301 mRNA-1273-P301-US327-2271US3272271US327USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DW6DV…HrDV¤Hr: DV¤Hr: DWHr×HDW6HrúJüDW6HrúJü.DW]DV…DWDW.DV…DWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BCmôBCÛèmRNA-1273-P301 mRNA-1273-P301-US327-2272US3272272US327USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWPDV…Hr”DV¥Hr;0|DV¥Hr;0|DWPHs°8DWPHs°8...DW]DV…DWODWP.DV…DWODWP. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BØmRNA-1273-P301 mRNA-1273-P301-US327-2305US3272305US327USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DW)DV†Hr:PDV¤Hr9ÅpDV¤Hr9ÅpDWHrÈ<DW)Hré¨DW)Hré¨.DW]DV†DWDW.DV†DWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B;mRNA-1273-P301 mRNA-1273-P301-US327-2305US3272305US327USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DW)DV†Hr:PDV¤Hr9ÅpDV¤Hr9ÅpDWHrÈ<DW)Hré¨DW)Hré¨.DW]DV†DWDW.DV†DWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B;B;mômRNA-1273-P301 mRNA-1273-P301-US327-2305US3272305US327USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DW)DV†Hr:PDV¤Hr9ÅpDV¤Hr9ÅpDWHrÈ<DW)Hré¨DW)Hré¨.DW]DV†DWDW.DV†DWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B;môB;ÛæmRNA-1273-P301 mRNA-1273-P301-US327-2317US3272317US327USABQYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DW+DV†Hr^¤DV¦Hr<âŒDV¦Hr<âŒDWHrÂéàDW+HrëÀ¤DW+HrëÀ¤.DW]DV†DWDW.DV†DWDW. >=65 Years A0B¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BRmRNA-1273-P301 mRNA-1273-P301-US327-2317US3272317US327USABQYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DW+DV†Hr^¤DV¦Hr<âŒDV¦Hr<âŒDWHrÂéàDW+HrëÀ¤DW+HrëÀ¤.DW]DV†DWDW.DV†DWDW. >=65 Years A0B¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BRBRmômRNA-1273-P301 mRNA-1273-P301-US327-2317US3272317US327USABQYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DW+DV†Hr^¤DV¦Hr<âŒDV¦Hr<âŒDWHrÂéàDW+HrëÀ¤DW+HrëÀ¤.DW]DV†DWDW.DV†DWDW. >=65 Years A0B¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BRmôBRÛèmRNA-1273-P301 mRNA-1273-P301-US327-2317US3272317US327USABQYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DW+DV†Hr^¤DV¦Hr<âŒDV¦Hr<âŒDWHrÂéàDW+HrëÀ¤DW+HrëÀ¤.DW]DV†DWDW.DV†DWDW. >=65 Years A0B¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BRÛèBRIÜmRNA-1273-P301 mRNA-1273-P301-US327-2329US3272329US327USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DWBDV†Hr€(DV§Hr=§¨DV§Hr=§¨DWBHs üDWBHs ü...DW]DV†DWADWB.DV†DWADWB. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BGmRNA-1273-P301 mRNA-1273-P301-US327-2342US3272342US327USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DWZDV†Hr¢ØDV¦Hr<á$DV¦Hr<á$DW@Hst DWZHs)¼LDWZHs)¼L.DW]DV†DW?DW@.DV†DW?DW@. Diabetes >=18 and <65 Years and at Risk A B¸Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BemRNA-1273-P301 mRNA-1273-P301-US327-2342US3272342US327USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DWZDV†Hr¢ØDV¦Hr<á$DV¦Hr<á$DW@Hst DWZHs)¼LDWZHs)¼L.DW]DV†DW?DW@.DV†DW?DW@. Diabetes >=18 and <65 Years and at Risk A B¸Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BeBemômRNA-1273-P301 mRNA-1273-P301-US327-2342US3272342US327USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DWZDV†Hr¢ØDV¦Hr<á$DV¦Hr<á$DW@Hst DWZHs)¼LDWZHs)¼L.DW]DV†DW?DW@.DV†DW?DW@. Diabetes >=18 and <65 Years and at Risk A B¸Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BemôBeÛèmRNA-1273-P301 mRNA-1273-P301-US327-2342US3272342US327USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV†DWZDV†Hr¢ØDV¦Hr<á$DV¦Hr<á$DW@Hst DWZHs)¼LDWZHs)¼L.DW]DV†DW?DW@.DV†DW?DW@. Diabetes >=18 and <65 Years and at Risk A B¸Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BeÛèBeIÜmRNA-1273-P301 mRNA-1273-P301-US327-2357US3272357US327USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW+DVˆHrõ8DV¤Hr9ÏüDV¤Hr9ÏüDWHrÆÖ,DW+HrëÇ¬DW+HrëÇ¬.DW]DVˆDWDW.DVˆDWDW. Diabetes >=18 and <65 Years and at Risk A BºMinority .At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BMmRNA-1273-P301 mRNA-1273-P301-US327-2357US3272357US327USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW+DVˆHrõ8DV¤Hr9ÏüDV¤Hr9ÏüDWHrÆÖ,DW+HrëÇ¬DW+HrëÇ¬.DW]DVˆDWDW.DVˆDWDW. Diabetes >=18 and <65 Years and at Risk A BºMinority .At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BMBMmômRNA-1273-P301 mRNA-1273-P301-US327-2357US3272357US327USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW+DVˆHrõ8DV¤Hr9ÏüDV¤Hr9ÏüDWHrÆÖ,DW+HrëÇ¬DW+HrëÇ¬.DW]DVˆDWDW.DVˆDWDW. Diabetes >=18 and <65 Years and at Risk A BºMinority .At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BMmôBMÛèmRNA-1273-P301 mRNA-1273-P301-US327-2357US3272357US327USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW+DVˆHrõ8DV¤Hr9ÏüDV¤Hr9ÏüDWHrÆÖ,DW+HrëÇ¬DW+HrëÇ¬.DW]DVˆDWDW.DVˆDWDW. Diabetes >=18 and <65 Years and at Risk A BºMinority .At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BMÛèBMIÜmRNA-1273-P301 mRNA-1273-P301-US327-2366US3272366US327USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWRDV‹Hrý¤DV¬HrDmÌDV¬HrDmÌDW9HrþUDWRHsQXDWRHsQX.DW]DV‹DW8DW9.DV‹DW8DW9. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BWmRNA-1273-P301 mRNA-1273-P301-US327-2366US3272366US327USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWRDV‹Hrý¤DV¬HrDmÌDV¬HrDmÌDW9HrþUDWRHsQXDWRHsQX.DW]DV‹DW8DW9.DV‹DW8DW9. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BWBWmômRNA-1273-P301 mRNA-1273-P301-US327-2366US3272366US327USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWRDV‹Hrý¤DV¬HrDmÌDV¬HrDmÌDW9HrþUDWRHsQXDWRHsQX.DW]DV‹DW8DW9.DV‹DW8DW9. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BWmôBWÛèmRNA-1273-P301 mRNA-1273-P301-US327-2366US3272366US327USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWRDV‹Hrý¤DV¬HrDmÌDV¬HrDmÌDW9HrþUDWRHsQXDWRHsQX.DW]DV‹DW8DW9.DV‹DW8DW9. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BWÛèBWIÜmRNA-1273-P301 mRNA-1273-P301-US328-2072US3282072US328USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWADV„Hr†èDV£Hr8X„DV£Hr8X„DW"Hrà¨DWAHsÈ¬DWAHsÈ¬.DW]DV„DW!DW".DV„DW!DW". >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBRmRNA-1273-P301 mRNA-1273-P301-US328-2072US3282072US328USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWADV„Hr†èDV£Hr8X„DV£Hr8X„DW"Hrà¨DWAHsÈ¬DWAHsÈ¬.DW]DV„DW!DW".DV„DW!DW". >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBRBRmômRNA-1273-P301 mRNA-1273-P301-US329-2102US3292102US329USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWRDVwHqþã$DV“Hr#ZDV“Hr#ZDW0Hròm<DWRHs> DWRHs> .DW]DVwDW/DW0.DVwDW/DW0. >=18 and <65 Years and Not at RiskABËNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BˆmRNA-1273-P301 mRNA-1273-P301-US329-2102US3292102US329USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWRDVwHqþã$DV“Hr#ZDV“Hr#ZDW0Hròm<DWRHs> DWRHs> .DW]DVwDW/DW0.DVwDW/DW0. >=18 and <65 Years and Not at RiskABËNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BˆBˆmðmRNA-1273-P301 mRNA-1273-P301-US329-2102US3292102US329USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWRDVwHqþã$DV“Hr#ZDV“Hr#ZDW0Hròm<DWRHs> DWRHs> .DW]DVwDW/DW0.DVwDW/DW0. >=18 and <65 Years and Not at RiskABËNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BˆmðBˆÛèmRNA-1273-P301 mRNA-1273-P301-US329-2109US3292109US329USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWEDVzHreøDV–Hr'@DV–Hr'@DWEHspDWEHsp...DW]DVzDWDDWE.DVzDWDDWE. >=18 and <65 Years and Not at RiskABÈMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B•mRNA-1273-P301 mRNA-1273-P301-US329-2188US3292188US329USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWGDV~HrÔÀDVšHr,ÔPDVšHr,ÔPDWGHsýØDWGHsýØ...DW]DV~DWFDWG.DV~DWFDWG. >=18 and <65 Years and Not at RiskABÄNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBžmRNA-1273-P301 mRNA-1273-P301-US329-2188US3292188US329USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWGDV~HrÔÀDVšHr,ÔPDVšHr,ÔPDWGHsýØDWGHsýØ...DW]DV~DWFDWG.DV~DWFDWG. >=18 and <65 Years and Not at RiskABÄNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBžBžmðmRNA-1273-P301 mRNA-1273-P301-US329-2218US3292218US329USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWEDVHrÂìDVHr0‹,DVHr0‹,DWEHs7ìDWEHs7ì...DW]DVDWDDWE.DVDWDDWE. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B“mRNA-1273-P301 mRNA-1273-P301-US329-2280US3292280US329USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWRDV„Hrä0DV Hr4¡lDV Hr4¡lDWRHs^´DWRHs^´...DW]DV„DWQDWR.DV„DWQDWR. >=18 and <65 Years and Not at RiskAB¾Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmmRNA-1273-P301 mRNA-1273-P301-US329-2289US3292289US329USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHrà˜DV¤Hr9ÓøDV¤Hr9Óø.......DW]DVˆDWDWDWDVˆDWDWDWChronic Lung Disease >=18 and <65 Years and at Risk A BcMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BHmRNA-1273-P301 mRNA-1273-P301-US329-2289US3292289US329USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHrà˜DV¤Hr9ÓøDV¤Hr9Óø.......DW]DVˆDWDWDWDVˆDWDWDWChronic Lung Disease >=18 and <65 Years and at Risk A BcMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BHBHmômRNA-1273-P301 mRNA-1273-P301-US329-2289US3292289US329USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHrà˜DV¤Hr9ÓøDV¤Hr9Óø.......DW]DVˆDWDWDWDVˆDWDWDWChronic Lung Disease >=18 and <65 Years and at Risk A BcMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BHmôBHÛèmRNA-1273-P301 mRNA-1273-P301-US329-2289US3292289US329USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHrà˜DV¤Hr9ÓøDV¤Hr9Óø.......DW]DVˆDWDWDWDVˆDWDWDWChronic Lung Disease >=18 and <65 Years and at Risk A BcMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BHÛèBHIÜmRNA-1273-P301 mRNA-1273-P301-US329-2320US3292320US329USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHr4DDV¤Hr:øDV¤Hr:ø.......DW]DVˆDWDDWE.DVˆDWDDWE. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BUmRNA-1273-P301 mRNA-1273-P301-US329-2320US3292320US329USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHr4DDV¤Hr:øDV¤Hr:ø.......DW]DVˆDWDDWE.DVˆDWDDWE. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BUBUmômRNA-1273-P301 mRNA-1273-P301-US329-2320US3292320US329USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHr4DDV¤Hr:øDV¤Hr:ø.......DW]DVˆDWDDWE.DVˆDWDDWE. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BUmôBUÛèmRNA-1273-P301 mRNA-1273-P301-US329-2322US3292322US329USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŠDV¦DVŠHrŒDV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B…mRNA-1273-P301 mRNA-1273-P301-US329-2395US3292395US329USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWEDVŸHr33DV»HrX¬DV»HrX¬DWEHs[ÈDWEHs[È...DW]DVŸDWDDWE.DVŸDWDDWE. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB8mRNA-1273-P301 mRNA-1273-P301-US329-2395US3292395US329USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWEDVŸHr33DV»HrX¬DV»HrX¬DWEHs[ÈDWEHs[È...DW]DVŸDWDDWE.DVŸDWDDWE. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB8B8mômRNA-1273-P301 mRNA-1273-P301-US329-2411US3292411US329USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DWGDV¦Hr=18 and <65 Years and Not at RiskABœMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB`mRNA-1273-P301 mRNA-1273-P301-US329-2411US3292411US329USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DWGDV¦Hr=18 and <65 Years and Not at RiskABœMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB`B`mômRNA-1273-P301 mRNA-1273-P301-US329-2413US3292413US329USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV¦DVÂDV¦Hr=18 and <65 Years and Not at RiskABœMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBgmRNA-1273-P301 mRNA-1273-P301-US329-2413US3292413US329USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV¦DVÂDV¦Hr=18 and <65 Years and Not at RiskABœMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBgBgmômRNA-1273-P301 mRNA-1273-P301-US330-2042US3302042US330USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWHDVtHqúz(DV’Hr"ŒDV’Hr"ŒDW,HríDWHHsêÌDWHHsêÌ.DW]DVtDW+DW,.DVtDW+DW,. Severe Obesity >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‹mRNA-1273-P301 mRNA-1273-P301-US330-2042US3302042US330USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWHDVtHqúz(DV’Hr"ŒDV’Hr"ŒDW,HríDWHHsêÌDWHHsêÌ.DW]DVtDW+DW,.DVtDW+DW,. Severe Obesity >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‹B‹mðmRNA-1273-P301 mRNA-1273-P301-US330-2042US3302042US330USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWHDVtHqúz(DV’Hr"ŒDV’Hr"ŒDW,HríDWHHsêÌDWHHsêÌ.DW]DVtDW+DW,.DVtDW+DW,. Severe Obesity >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‹mðB‹ÛèmRNA-1273-P301 mRNA-1273-P301-US330-2062US3302062US330USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW0DVuHqûÀ,DV‘Hr £$DV‘Hr £$DWHrÍœDW0Hrò„4DW0Hrò„4.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB~mRNA-1273-P301 mRNA-1273-P301-US330-2062US3302062US330USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW0DVuHqûÀ,DV‘Hr £$DV‘Hr £$DWHrÍœDW0Hrò„4DW0Hrò„4.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB~B~mômRNA-1273-P301 mRNA-1273-P301-US330-2143US3302143US330USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWNDVzHr¢4DV–Hr'|¼DV–Hr'|¼DW2Hrõ-DWNHsdDWNHsd.DW]DVzDW1DW2.DVzDW1DW2. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‡mRNA-1273-P301 mRNA-1273-P301-US330-2161US3302161US330USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWADV{HrÓ\DV—Hr(²XDV—Hr(²XDWHrÙ¢ÔDWAHsÏ<DWAHsÏ<.DW]DV{DWDW.DV{DWDW. Diabetes >=18 and <65 Years and at Risk A BÇNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB|mRNA-1273-P301 mRNA-1273-P301-US330-2161US3302161US330USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWADV{HrÓ\DV—Hr(²XDV—Hr(²XDWHrÙ¢ÔDWAHsÏ<DWAHsÏ<.DW]DV{DWDW.DV{DWDW. Diabetes >=18 and <65 Years and at Risk A BÇNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB|B|mômRNA-1273-P301 mRNA-1273-P301-US330-2187US3302187US330USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DV˜DV|Hr%DV˜Hr)ùLDV˜Hr)ùL.......DW]DV|DW(DW).DV|DW(DW). >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB‰mRNA-1273-P301 mRNA-1273-P301-US330-2187US3302187US330USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DV˜DV|Hr%DV˜Hr)ùLDV˜Hr)ùL.......DW]DV|DW(DW).DV|DW(DW). >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB‰B‰mðmRNA-1273-P301 mRNA-1273-P301-US330-2221US3302221US330USAB3YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWSDV}Hr² DV™Hr+<€DV™Hr+<€DW7HrûÑ8DWSHs Ï`DWSHs Ï`.DW]DV}DW6DW7.DV}DW6DW7. Severe Obesity >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBomRNA-1273-P301 mRNA-1273-P301-US330-2221US3302221US330USAB3YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWSDV}Hr² DV™Hr+<€DV™Hr+<€DW7HrûÑ8DWSHs Ï`DWSHs Ï`.DW]DV}DW6DW7.DV}DW6DW7. Severe Obesity >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBoBomômRNA-1273-P301 mRNA-1273-P301-US330-2229US3302229US330USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW@DV€Hr _ØDVœHr/xDVœHr/xDW$Hrâ×xDW@Hs· DW@Hs· .DW]DV€DW#DW$.DV€DW#DW$. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB€mRNA-1273-P301 mRNA-1273-P301-US330-2229US3302229US330USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW@DV€Hr _ØDVœHr/xDVœHr/xDW$Hrâ×xDW@Hs· DW@Hs· .DW]DV€DW#DW$.DV€DW#DW$. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB€B€mðmRNA-1273-P301 mRNA-1273-P301-US330-2236US3302236US330USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW@DV€Hr ‰DVœHr/wPDVœHr/wPDW$HrâÕ˜DW@Hs·ÜDW@Hs·Ü.DW]DV€DW#DW$.DV€DW#DW$. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US330-2236US3302236US330USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW@DV€Hr ‰DVœHr/wPDVœHr/wPDW$HrâÕ˜DW@Hs·ÜDW@Hs·Ü.DW]DV€DW#DW$.DV€DW#DW$. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmômRNA-1273-P301 mRNA-1273-P301-US330-2236US3302236US330USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW@DV€Hr ‰DVœHr/wPDVœHr/wPDW$HrâÕ˜DW@Hs·ÜDW@Hs·Ü.DW]DV€DW#DW$.DV€DW#DW$. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmôBÛèmRNA-1273-P301 mRNA-1273-P301-US330-2318US3302318US330USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWEDV„HrŸüDVŸHr3"°DVŸHr3"°DW)Hré8DWEHs ë„DWEHs ë„.DW]DV„DW(DW).DV„DW(DW). >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‚mRNA-1273-P301 mRNA-1273-P301-US330-2318US3302318US330USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWEDV„HrŸüDVŸHr3"°DVŸHr3"°DW)Hré8DWEHs ë„DWEHs ë„.DW]DV„DW(DW).DV„DW(DW). >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‚B‚mðmRNA-1273-P301 mRNA-1273-P301-US330-2318US3302318US330USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWEDV„HrŸüDVŸHr3"°DVŸHr3"°DW)Hré8DWEHs ë„DWEHs ë„.DW]DV„DW(DW).DV„DW(DW). >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‚mðB‚ÛèmRNA-1273-P301 mRNA-1273-P301-US330-2333US3302333US330USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW@DV‡Hr~8DV£Hr8^`DV£Hr8^`DW$Hrâ¶lDW@Hs˜ìDW@Hs˜ì.DW]DV‡DW#DW$.DV‡DW#DW$. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB1mRNA-1273-P301 mRNA-1273-P301-US330-2333US3302333US330USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW@DV‡Hr~8DV£Hr8^`DV£Hr8^`DW$Hrâ¶lDW@Hs˜ìDW@Hs˜ì.DW]DV‡DW#DW$.DV‡DW#DW$. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB1B1mômRNA-1273-P301 mRNA-1273-P301-US330-2348US3302348US330USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW@DV‡HrÏDV£Hr8¢XDV£Hr8¢XDW$HrâÇLDW@Hs¨(DW@Hs¨(.DW]DV‡DW#DW$.DV‡DW#DW$. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BxmRNA-1273-P301 mRNA-1273-P301-US330-2379US3302379US330USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNNYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW\DV‰Hr>„DV¥Hr;ˆDV¥Hr;ˆDW?Hs„DW\Hs,?¨DW\Hs,?¨.DW]DV‰DW>DW?.DV‰DW>DW?. Diabetes >=18 and <65 Years and at Risk A B¹Non-minorityNon-caucasianA At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B–mRNA-1273-P301 mRNA-1273-P301-US330-2381US3302381US330USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰Hr@(DV¥Hr;'DV¥Hr;'DW)HrèþxDWEHs ê”DWEHs ê”.DW]DV‰DW(DW).DV‰DW(DW).Chronic Lung Disease Diabetes >=18 and <65 Years and at Risk A B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBnmRNA-1273-P301 mRNA-1273-P301-US330-2381US3302381US330USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰Hr@(DV¥Hr;'DV¥Hr;'DW)HrèþxDWEHs ê”DWEHs ê”.DW]DV‰DW(DW).DV‰DW(DW).Chronic Lung Disease Diabetes >=18 and <65 Years and at Risk A B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBnBnmômRNA-1273-P301 mRNA-1273-P301-US330-2458US3302458US330USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DWUDV¤Hr9Î”DV¿Hr][˜DV¿Hr][˜DW7HrûvHDWUHs#´DWUHs#´.DW]DV¤DW6DW7.DV¤DW6DW7. >=65 Years A0BŸMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBjmRNA-1273-P301 mRNA-1273-P301-US330-2458US3302458US330USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DWUDV¤Hr9Î”DV¿Hr][˜DV¿Hr][˜DW7HrûvHDWUHs#´DWUHs#´.DW]DV¤DW6DW7.DV¤DW6DW7. >=65 Years A0BŸMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBjBjmômRNA-1273-P301 mRNA-1273-P301-US330-2470US3302470US330USAB!YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV²DWGDV²HrLsÜDVÎHrqWÄDVÎHrqWÄDWGHs\DWGHs\...DW]DV²DWFDWG.DV²DWFDWG. Severe Obesity >=18 and <65 Years and at Risk A BMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB^mRNA-1273-P301 mRNA-1273-P301-US330-2470US3302470US330USAB!YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV²DWGDV²HrLsÜDVÎHrqWÄDVÎHrqWÄDWGHs\DWGHs\...DW]DV²DWFDWG.DV²DWFDWG. Severe Obesity >=18 and <65 Years and at Risk A BMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB^B^mômRNA-1273-P301 mRNA-1273-P301-US331-2005US3312005US331USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDWDDVyHr7ÜDV•Hr%þðDV•Hr%þðDW(HrèpDWDHs±8DWDHs±8.DW]DVyDW'DW(.DVyDW'DW(. >=18 and <65 Years and Not at RiskABÉNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B“mRNA-1273-P301 mRNA-1273-P301-US331-2005US3312005US331USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDWDDVyHr7ÜDV•Hr%þðDV•Hr%þðDW(HrèpDWDHs±8DWDHs±8.DW]DVyDW'DW(.DVyDW'DW(. >=18 and <65 Years and Not at RiskABÉNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B“B“mðmRNA-1273-P301 mRNA-1273-P301-US331-2005US3312005US331USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDWDDVyHr7ÜDV•Hr%þðDV•Hr%þðDW(HrèpDWDHs±8DWDHs±8.DW]DVyDW'DW(.DVyDW'DW(. >=18 and <65 Years and Not at RiskABÉNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B“mðB“ÛèmRNA-1273-P301 mRNA-1273-P301-US331-2053US3312053US331USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWKDV{HrúDDV—Hr(ß”DV—Hr(ß”DW/Hrñ:pDWKHs"DWKHs".DW]DV{DW.DW/.DV{DW.DW/. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B•mRNA-1273-P301 mRNA-1273-P301-US331-2053US3312053US331USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWKDV{HrúDDV—Hr(ß”DV—Hr(ß”DW/Hrñ:pDWKHs"DWKHs".DW]DV{DW.DW/.DV{DW.DW/. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B•B•mðmRNA-1273-P301 mRNA-1273-P301-US331-2053US3312053US331USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWKDV{HrúDDV—Hr(ß”DV—Hr(ß”DW/Hrñ:pDWKHs"DWKHs".DW]DV{DW.DW/.DV{DW.DW/. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B•mðB•ÛèmRNA-1273-P301 mRNA-1273-P301-US331-2086US3312086US331USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWRDV}Hr˜”DV™Hr+jèDV™Hr+jèDW6Hrú~ÈDWRHsYÈDWRHsYÈ.DW]DV}DW5DW6.DV}DW5DW6. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B™mRNA-1273-P301 mRNA-1273-P301-US331-2086US3312086US331USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWRDV}Hr˜”DV™Hr+jèDV™Hr+jèDW6Hrú~ÈDWRHsYÈDWRHsYÈ.DW]DV}DW5DW6.DV}DW5DW6. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B™B™mðmRNA-1273-P301 mRNA-1273-P301-US331-2086US3312086US331USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWRDV}Hr˜”DV™Hr+jèDV™Hr+jèDW6Hrú~ÈDWRHsYÈDWRHsYÈ.DW]DV}DW5DW6.DV}DW5DW6. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B™mðB™ÛèmRNA-1273-P301 mRNA-1273-P301-US331-2110US3312110US331USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWFDV€Hr ˜DVœHr/YDVœHr/YDWFHs¦ôDWFHs¦ô...DW]DV€DWEDWF.DV€DWEDWF. >=18 and <65 Years and Not at RiskABÂMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B†mRNA-1273-P301 mRNA-1273-P301-US331-2110US3312110US331USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWFDV€Hr ˜DVœHr/YDVœHr/YDWFHs¦ôDWFHs¦ô...DW]DV€DWEDWF.DV€DWEDWF. >=18 and <65 Years and Not at RiskABÂMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B†B†mðmRNA-1273-P301 mRNA-1273-P301-US331-2110US3312110US331USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWFDV€Hr ˜DVœHr/YDVœHr/YDWFHs¦ôDWFHs¦ô...DW]DV€DWEDWF.DV€DWEDWF. >=18 and <65 Years and Not at RiskABÂMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B†mðB†ÛèmRNA-1273-P301 mRNA-1273-P301-US331-2177US3312177US331USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWEDVƒHrC´DVŸHr3flDVŸHr3flDW)HréN(DWEHsüDWEHsü.DW]DVƒDW(DW).DVƒDW(DW). >=65 Years A0B¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B‹mRNA-1273-P301 mRNA-1273-P301-US331-2177US3312177US331USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWEDVƒHrC´DVŸHr3flDVŸHr3flDW)HréN(DWEHsüDWEHsü.DW]DVƒDW(DW).DVƒDW(DW). >=65 Years A0B¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B‹B‹mðmRNA-1273-P301 mRNA-1273-P301-US331-2177US3312177US331USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWEDVƒHrC´DVŸHr3flDVŸHr3flDW)HréN(DWEHsüDWEHsü.DW]DVƒDW(DW).DVƒDW(DW). >=65 Years A0B¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B‹mðB‹ÛèmRNA-1273-P301 mRNA-1273-P301-US331-2177US3312177US331USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWEDVƒHrC´DVŸHr3flDVŸHr3flDW)HréN(DWEHsüDWEHsü.DW]DVƒDW(DW).DVƒDW(DW). >=65 Years A0B¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B‹ÛèB‹IØmRNA-1273-P301 mRNA-1273-P301-US331-2206US3312206US331USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWIDV„HrDV¤Hr9ÊÔDV¤Hr9ÊÔDW,Hrí=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BtmRNA-1273-P301 mRNA-1273-P301-US331-2225US3312225US331USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV£DV‡HrìDV£Hr8mØDV£Hr8mØ.......DW]DV‡DW#DW$.DV‡DW#DW$. Diabetes >=18 and <65 Years and at Risk A B»Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BHmRNA-1273-P301 mRNA-1273-P301-US331-2225US3312225US331USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV£DV‡HrìDV£Hr8mØDV£Hr8mØ.......DW]DV‡DW#DW$.DV‡DW#DW$. Diabetes >=18 and <65 Years and at Risk A B»Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BHBHmômRNA-1273-P301 mRNA-1273-P301-US331-2225US3312225US331USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV£DV‡HrìDV£Hr8mØDV£Hr8mØ.......DW]DV‡DW#DW$.DV‡DW#DW$. Diabetes >=18 and <65 Years and at Risk A B»Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BHmôBHÛèmRNA-1273-P301 mRNA-1273-P301-US331-2235US3312235US331USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWDDV‡Hr¤0DV£Hr8±ÐDV£Hr8±ÐDW(HrçÝôDWDHsÕŒDWDHsÕŒ.DW]DV‡DW'DW(.DV‡DW'DW(. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBMmRNA-1273-P301 mRNA-1273-P301-US331-2235US3312235US331USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWDDV‡Hr¤0DV£Hr8±ÐDV£Hr8±ÐDW(HrçÝôDWDHsÕŒDWDHsÕŒ.DW]DV‡DW'DW(.DV‡DW'DW(. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBMBMmômRNA-1273-P301 mRNA-1273-P301-US331-2296US3312296US331USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWADV‰HrSœDV¥Hr; DV¥Hr; DWHrÚ²´DWAHsÐhDWAHsÐh.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B?mRNA-1273-P301 mRNA-1273-P301-US331-2296US3312296US331USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWADV‰HrSœDV¥Hr; DV¥Hr; DWHrÚ²´DWAHsÐhDWAHsÐh.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B?B?mômRNA-1273-P301 mRNA-1273-P301-US331-2296US3312296US331USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWADV‰HrSœDV¥Hr; DV¥Hr; DWHrÚ²´DWAHsÐhDWAHsÐh.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B?môB?ÛæmRNA-1273-P301 mRNA-1273-P301-US331-2296US3312296US331USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWADV‰HrSœDV¥Hr; DV¥Hr; DWHrÚ²´DWAHsÐhDWAHsÐh.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B?ÛæB?IÚmRNA-1273-P301 mRNA-1273-P301-US331-2307US3312307US331USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW9DV‰Hr€ØDV¥Hr;JDV¥Hr;JDWHrÙˆ”DW9Hrþj`DW9Hrþj`.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BhmRNA-1273-P301 mRNA-1273-P301-US331-2307US3312307US331USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW9DV‰Hr€ØDV¥Hr;JDV¥Hr;JDWHrÙˆ”DW9Hrþj`DW9Hrþj`.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BhBhmômRNA-1273-P301 mRNA-1273-P301-US331-2307US3312307US331USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW9DV‰Hr€ØDV¥Hr;JDV¥Hr;JDWHrÙˆ”DW9Hrþj`DW9Hrþj`.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BhmôBhÛèmRNA-1273-P301 mRNA-1273-P301-US331-2330US3312330US331USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWHDVŠHr¡\DV¥Hr;aDV¥Hr;aDWHHsüœDWHHsüœ...DW]DVŠDWGDWH.DVŠDWGDWH. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BÓmRNA-1273-P301 mRNA-1273-P301-US331-2342US3312342US331USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWIDVŠHr»$DV¦Hr<¤DV¦Hr<¤DW-Hrî«˜DWIHsZÄDWIHsZÄ.DW]DVŠDW,DW-.DVŠDW,DW-. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB{mRNA-1273-P301 mRNA-1273-P301-US331-2342US3312342US331USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWIDVŠHr»$DV¦Hr<¤DV¦Hr<¤DW-Hrî«˜DWIHsZÄDWIHsZÄ.DW]DVŠDW,DW-.DVŠDW,DW-. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB{B{mômRNA-1273-P301 mRNA-1273-P301-US331-2356US3312356US331USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWODV‹Hr×èDV§Hr=ñôDV§Hr=ñôDW6Hrúu¤DWOHsi¼DWOHsi¼.DW]DV‹DW5DW6.DV‹DW5DW6. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmRNA-1273-P301 mRNA-1273-P301-US331-2356US3312356US331USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWODV‹Hr×èDV§Hr=ñôDV§Hr=ñôDW6Hrúu¤DWOHsi¼DWOHsi¼.DW]DV‹DW5DW6.DV‹DW5DW6. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBmðmRNA-1273-P301 mRNA-1273-P301-US331-2388US3312388US331USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHrÁ(DVªHrA¤ DVªHrA¤ DW$Hrâ|ÄDW@Hs] DW@Hs] .DW]DVŽDW#DW$.DVŽDW#DW$. >=18 and <65 Years and Not at RiskAB´Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BqmRNA-1273-P301 mRNA-1273-P301-US331-2388US3312388US331USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHrÁ(DVªHrA¤ DVªHrA¤ DW$Hrâ|ÄDW@Hs] DW@Hs] .DW]DVŽDW#DW$.DVŽDW#DW$. >=18 and <65 Years and Not at RiskAB´Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BqBqmômRNA-1273-P301 mRNA-1273-P301-US331-2388US3312388US331USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHrÁ(DVªHrA¤ DVªHrA¤ DW$Hrâ|ÄDW@Hs] DW@Hs] .DW]DVŽDW#DW$.DVŽDW#DW$. >=18 and <65 Years and Not at RiskAB´Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BqmôBqÛèmRNA-1273-P301 mRNA-1273-P301-US331-2402US3312402US331USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW9DVŽHrþTDVªHrAéDDVªHrAéDDWHrÙ| DW9HrþcXDW9HrþcX.DW]DVŽDWDW.DVŽDWDW. >=18 and <65 Years and Not at RiskAB´Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B5mRNA-1273-P301 mRNA-1273-P301-US331-2437US3312437US331USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW@DVHrS”DV«HrC8lDV«HrC8lDW$Hrâ¡DW@Hs°ÔDW@Hs°Ô.DW]DVDW#DW$.DVDW#DW$. >=65 Years A0B³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBvmRNA-1273-P301 mRNA-1273-P301-US331-2437US3312437US331USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW@DVHrS”DV«HrC8lDV«HrC8lDW$Hrâ¡DW@Hs°ÔDW@Hs°Ô.DW]DVDW#DW$.DVDW#DW$. >=65 Years A0B³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBvBvmômRNA-1273-P301 mRNA-1273-P301-US331-2439US3312439US331USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHrZ`DV«HrC:ÄDV«HrC:ÄDW?HsXÄDW?HsXÄ...DW]DVDW>DW?.DVDW>DW?. Severe Obesity >=18 and <65 Years and at Risk A B³Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B”mRNA-1273-P301 mRNA-1273-P301-US331-2439US3312439US331USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHrZ`DV«HrC:ÄDV«HrC:ÄDW?HsXÄDW?HsXÄ...DW]DVDW>DW?.DVDW>DW?. Severe Obesity >=18 and <65 Years and at Risk A B³Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B”B”mðmRNA-1273-P301 mRNA-1273-P301-US331-2439US3312439US331USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHrZ`DV«HrC:ÄDV«HrC:ÄDW?HsXÄDW?HsXÄ...DW]DVDW>DW?.DVDW>DW?. Severe Obesity >=18 and <65 Years and at Risk A B³Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B”mðB”ÛèmRNA-1273-P301 mRNA-1273-P301-US331-2581US3312581US331USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW9DV—Hr(è|DV³HrM·ÄDV³HrM·ÄDWHrÙ¬DW9Hrþ‚DW9Hrþ‚.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BSmRNA-1273-P301 mRNA-1273-P301-US331-2581US3312581US331USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW9DV—Hr(è|DV³HrM·ÄDV³HrM·ÄDWHrÙ¬DW9Hrþ‚DW9Hrþ‚.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BSBSmômRNA-1273-P301 mRNA-1273-P301-US331-2581US3312581US331USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW9DV—Hr(è|DV³HrM·ÄDV³HrM·ÄDWHrÙ¬DW9Hrþ‚DW9Hrþ‚.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BSmôBSÛèmRNA-1273-P301 mRNA-1273-P301-US331-2581US3312581US331USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW9DV—Hr(è|DV³HrM·ÄDV³HrM·ÄDWHrÙ¬DW9Hrþ‚DW9Hrþ‚.DW]DV—DWDW.DV—DWDW. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BSÛèBSIÜmRNA-1273-P301 mRNA-1273-P301-US331-2608US3312608US331USAB-YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWIDV˜Hr*9DV´HrOÈDV´HrOÈDW-HrîÇDWIHsYÔDWIHsYÔ.DW]DV˜DW,DW-.DV˜DW,DW-. Severe Obesity >=18 and <65 Years and at Risk A BªNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBFmRNA-1273-P301 mRNA-1273-P301-US331-2608US3312608US331USAB-YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWIDV˜Hr*9DV´HrOÈDV´HrOÈDW-HrîÇDWIHsYÔDWIHsYÔ.DW]DV˜DW,DW-.DV˜DW,DW-. Severe Obesity >=18 and <65 Years and at Risk A BªNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBFBFmômRNA-1273-P301 mRNA-1273-P301-US331-2622US3312622US331USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW9DV™Hr+V„DVµHrP, DVµHrP, DWHrÙ¡lDW9Hrþƒ°DW9Hrþƒ°.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B*mRNA-1273-P301 mRNA-1273-P301-US331-2622US3312622US331USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW9DV™Hr+V„DVµHrP, DVµHrP, DWHrÙ¡lDW9Hrþƒ°DW9Hrþƒ°.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B*B*mômRNA-1273-P301 mRNA-1273-P301-US331-2622US3312622US331USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW9DV™Hr+V„DVµHrP, DVµHrP, DWHrÙ¡lDW9Hrþƒ°DW9Hrþƒ°.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B*môB*ÛæmRNA-1273-P301 mRNA-1273-P301-US331-2622US3312622US331USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW9DV™Hr+V„DVµHrP, DVµHrP, DWHrÙ¡lDW9Hrþƒ°DW9Hrþƒ°.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B*ÛæB*IÚmRNA-1273-P301 mRNA-1273-P301-US331-2623US3312623US331USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWEDV™Hr+X DV¹HrUpDV¹HrUpDW)HréqÈDWEHsLDWEHsL.DW]DV™DW(DW).DV™DW(DW). >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B_mRNA-1273-P301 mRNA-1273-P301-US331-2623US3312623US331USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWEDV™Hr+X DV¹HrUpDV¹HrUpDW)HréqÈDWEHsLDWEHsL.DW]DV™DW(DW).DV™DW(DW). >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B_B_mômRNA-1273-P301 mRNA-1273-P301-US331-2623US3312623US331USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWEDV™Hr+X DV¹HrUpDV¹HrUpDW)HréqÈDWEHsLDWEHsL.DW]DV™DW(DW).DV™DW(DW). >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B_môB_ÛèmRNA-1273-P301 mRNA-1273-P301-US332-2064US3322064US332USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWHDV„HrÂèDV¥Hr;Y€DV¥Hr;Y€DWHHsDWHHs...DW]DV„DWDDWE.DV„DWGDWH. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US332-2064US3322064US332USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWHDV„HrÂèDV¥Hr;Y€DV¥Hr;Y€DWHHsDWHHs...DW]DV„DWDDWE.DV„DWGDWH. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmðmRNA-1273-P301 mRNA-1273-P301-US332-2064US3322064US332USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWHDV„HrÂèDV¥Hr;Y€DV¥Hr;Y€DWHHsDWHHs...DW]DV„DWDDWE.DV„DWGDWH. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US332-2123US3322123US332USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW]DVŠHr»œDV¦Hr<£øDV¦Hr<£øDWDHsúDW]Hs-»”DW]Hs-»”.DW]DVŠDW@DWA.DVŠDWCDWD. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B’mRNA-1273-P301 mRNA-1273-P301-US332-2123US3322123US332USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW]DVŠHr»œDV¦Hr<£øDV¦Hr<£øDWDHsúDW]Hs-»”DW]Hs-»”.DW]DVŠDW@DWA.DVŠDWCDWD. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B’B’mðmRNA-1273-P301 mRNA-1273-P301-US332-2123US3322123US332USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW]DVŠHr»œDV¦Hr<£øDV¦Hr<£øDWDHsúDW]Hs-»”DW]Hs-»”.DW]DVŠDW@DWA.DVŠDWCDWD. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B’mðB’ÛèmRNA-1273-P301 mRNA-1273-P301-US332-2204US3322204US332USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‘DVDV‘Hr ÌdDVHrE¢ðDVHrE¢ð......DWDWDV‘DWDWDWDV‘DWDWDW >=18 and <65 Years and Not at RiskABnNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BnmRNA-1273-P301 mRNA-1273-P301-US332-2256US3322256US332USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV–DV²DV–Hr'}pDV²HrLM¨DV²HrLM¨.......DW]DV–DWDWDWDV–DWDWDW >=18 and <65 Years and Not at RiskABnNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBomRNA-1273-P301 mRNA-1273-P301-US332-2256US3322256US332USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV–DV²DV–Hr'}pDV²HrLM¨DV²HrLM¨.......DW]DV–DWDWDWDV–DWDWDW >=18 and <65 Years and Not at RiskABnNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBoBomômRNA-1273-P301 mRNA-1273-P301-US332-2296US3322296US332USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWHDV˜Hr*LDVµHrP%DVµHrP%DW*Hrês DWHHsHŒDWHHsHŒ.DW]DV˜DW)DW*.DV˜DW)DW*. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmmRNA-1273-P301 mRNA-1273-P301-US332-2296US3322296US332USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWHDV˜Hr*LDVµHrP%DVµHrP%DW*Hrês DWHHsHŒDWHHsHŒ.DW]DV˜DW)DW*.DV˜DW)DW*. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BmBmmômRNA-1273-P301 mRNA-1273-P301-US332-2296US3322296US332USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWHDV˜Hr*LDVµHrP%DVµHrP%DW*Hrês DWHHsHŒDWHHsHŒ.DW]DV˜DW)DW*.DV˜DW)DW*. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmmôBmÛèmRNA-1273-P301 mRNA-1273-P301-US332-2301US3322301US332USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWHDV˜Hr*30DV´HrOäDV´HrOäDW*Hrêo`DWHHs5DWHHs5.DW]DV˜DW(DW).DV˜DW)DW*. >=18 and <65 Years and Not at RiskABªMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B[mRNA-1273-P301 mRNA-1273-P301-US332-2301US3322301US332USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWHDV˜Hr*30DV´HrOäDV´HrOäDW*Hrêo`DWHHs5DWHHs5.DW]DV˜DW(DW).DV˜DW)DW*. >=18 and <65 Years and Not at RiskABªMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B[B[mômRNA-1273-P301 mRNA-1273-P301-US332-2301US3322301US332USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWHDV˜Hr*30DV´HrOäDV´HrOäDW*Hrêo`DWHHs5DWHHs5.DW]DV˜DW(DW).DV˜DW)DW*. >=18 and <65 Years and Not at RiskABªMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B[môB[ÛèmRNA-1273-P301 mRNA-1273-P301-US332-2323US3322323US332USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV™DV»DV™Hr+¡„DV»HrX^@DV»HrX^@.......DW]DV™...DV™... >=18 and <65 Years and Not at RiskAB£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmmRNA-1273-P301 mRNA-1273-P301-US332-2323US3322323US332USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV™DV»DV™Hr+¡„DV»HrX^@DV»HrX^@.......DW]DV™...DV™... >=18 and <65 Years and Not at RiskAB£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBmBmmômRNA-1273-P301 mRNA-1273-P301-US332-2347US3322347US332USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW/DVHr0¢œDV¹HrUsDV¹HrUsDWHrÎýDW/Hrñ tDW/Hrñ t.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB¥Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BÀmRNA-1273-P301 mRNA-1273-P301-US332-2365US3322365US332USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWMDVŸHr3yàDVÀHr_PDVÀHr_PDW0Hrò…`DWMHsµ DWMHsµ .DW]DVŸDW*DW+.DVŸDW/DW0. >=18 and <65 Years and Not at RiskABžMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BMmRNA-1273-P301 mRNA-1273-P301-US332-2388US3322388US332USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVªDWGDVªHrAÖÀDVÆHrfÀDVÆHrfÀDWGHsÒ¸DWGHsÒ¸...DW]DVªDW>DW?.DVªDWFDWG. >=18 and <65 Years and Not at RiskAB˜Minority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BTmRNA-1273-P301 mRNA-1273-P301-US332-2388US3322388US332USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVªDWGDVªHrAÖÀDVÆHrfÀDVÆHrfÀDWGHsÒ¸DWGHsÒ¸...DW]DVªDW>DW?.DVªDWFDWG. >=18 and <65 Years and Not at RiskAB˜Minority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BTBTmômRNA-1273-P301 mRNA-1273-P301-US332-2388US3322388US332USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVªDWGDVªHrAÖÀDVÆHrfÀDVÆHrfÀDWGHsÒ¸DWGHsÒ¸...DW]DVªDW>DW?.DVªDWFDWG. >=18 and <65 Years and Not at RiskAB˜Minority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BTmôBTÛèmRNA-1273-P301 mRNA-1273-P301-US332-2400US3322400US332USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DW=DV³HrM¦äDVÝHr…tDVÝHr…tDW$HrâÆÔDW=HsÒ DW=HsÒ .DW]DV³DW#DW$.DV³DW#DW$. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB6mRNA-1273-P301 mRNA-1273-P301-US332-2400US3322400US332USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DW=DV³HrM¦äDVÝHr…tDVÝHr…tDW$HrâÆÔDW=HsÒ DW=HsÒ .DW]DV³DW#DW$.DV³DW#DW$. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB6B6mômRNA-1273-P301 mRNA-1273-P301-US332-2409US3322409US332USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DW3DV®HrG/¼DVÐHrt$@DVÐHrt$@DWHrÕHDW3HrölüDW3Hrölü.DW]DV®DWDW.DV®DWDW. >=18 and <65 Years and Not at RiskABŽNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B,mRNA-1273-P301 mRNA-1273-P301-US332-2412US3322412US332USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWDDV±HrKDVÐHrsÙ@DVÐHrsÙ@DW+HrëáìDWDHs¿ÀDWDHs¿À.DW]DV±DW*DW+.DV±DW*DW+. >=18 and <65 Years and Not at RiskABŽNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B^mRNA-1273-P301 mRNA-1273-P301-US332-2412US3322412US332USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWDDV±HrKDVÐHrsÙ@DVÐHrsÙ@DW+HrëáìDWDHs¿ÀDWDHs¿À.DW]DV±DW*DW+.DV±DW*DW+. >=18 and <65 Years and Not at RiskABŽNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B^B^mômRNA-1273-P301 mRNA-1273-P301-US332-2412US3322412US332USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWDDV±HrKDVÐHrsÙ@DVÐHrsÙ@DW+HrëáìDWDHs¿ÀDWDHs¿À.DW]DV±DW*DW+.DV±DW*DW+. >=18 and <65 Years and Not at RiskABŽNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B^môB^ÛèmRNA-1273-P301 mRNA-1273-P301-US333-2001US3332001US333USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW/DVrHqø?8DV‹Hr8DV‹Hr8DWHrÍÁ”DW/HrñFdDW/HrñFd.DW]DVrDWDW.DVrDWDW. >=65 Years A0BÓNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B;mRNA-1273-P301 mRNA-1273-P301-US333-2068US3332068US333USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‹DV¤DV‹HrðHDV¤Hr9ñ¼DV¤Hr9ñ¼.......DW]DV‹DWS..DV‹DWS.. >=18 and <65 Years and Not at RiskAB°Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US333-2068US3332068US333USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‹DV¤DV‹HrðHDV¤Hr9ñ¼DV¤Hr9ñ¼.......DW]DV‹DWS..DV‹DWS.. >=18 and <65 Years and Not at RiskAB°Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmðmRNA-1273-P301 mRNA-1273-P301-US333-2068US3332068US333USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‹DV¤DV‹HrðHDV¤Hr9ñ¼DV¤Hr9ñ¼.......DW]DV‹DWS..DV‹DWS.. >=18 and <65 Years and Not at RiskAB°Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US333-2101US3332101US333USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¼DWLDV¼HrYž¤DVØHr~› DVØHr~› DW+Hrì(<DWLHsCŒDWLHsCŒ.DW]DV¼DW*DW+.DV¼DW*DW+. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBSmRNA-1273-P301 mRNA-1273-P301-US333-2101US3332101US333USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¼DWLDV¼HrYž¤DVØHr~› DVØHr~› DW+Hrì(<DWLHsCŒDWLHsCŒ.DW]DV¼DW*DW+.DV¼DW*DW+. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBSBSmômRNA-1273-P301 mRNA-1273-P301-US334-2019US3342019US334USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV–DVzHri¸DV–Hr'HDV–Hr'H......DVþDVþDVzDW"..DVzDW".. Severe Obesity >=18 and <65 Years and at Risk A BNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BimRNA-1273-P301 mRNA-1273-P301-US334-2019US3342019US334USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV–DVzHri¸DV–Hr'HDV–Hr'H......DVþDVþDVzDW"..DVzDW".. Severe Obesity >=18 and <65 Years and at Risk A BNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BiBimômRNA-1273-P301 mRNA-1273-P301-US334-2019US3342019US334USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV–DVzHri¸DV–Hr'HDV–Hr'H......DVþDVþDVzDW"..DVzDW".. Severe Obesity >=18 and <65 Years and at Risk A BNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BimôBiÛèmRNA-1273-P301 mRNA-1273-P301-US334-2019US3342019US334USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVzDV–DVzHri¸DV–Hr'HDV–Hr'H......DVþDVþDVzDW"..DVzDW".. Severe Obesity >=18 and <65 Years and at Risk A BNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BiÛèBiIÜmRNA-1273-P301 mRNA-1273-P301-US334-2025US3342025US334USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWADVzHr¡DDVHr0ÚdDVHr0ÚdDW$HrâÉhDWAHs DWAHs .DW]DVzDW#DW$.DVzDW#DW$. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B†mRNA-1273-P301 mRNA-1273-P301-US334-2025US3342025US334USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWADVzHr¡DDVHr0ÚdDVHr0ÚdDW$HrâÉhDWAHs DWAHs .DW]DVzDW#DW$.DVzDW#DW$. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B†B†mðmRNA-1273-P301 mRNA-1273-P301-US334-2025US3342025US334USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWADVzHr¡DDVHr0ÚdDVHr0ÚdDW$HrâÉhDWAHs DWAHs .DW]DVzDW#DW$.DVzDW#DW$. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B†mðB†ÛèmRNA-1273-P301 mRNA-1273-P301-US334-2026US3342026US334USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWKDVzHr¥@DVHr0ØüDVHr0ØüDW/HrñÔDWKHsöDDWKHsöD.DW]DVzDW.DW/.DVzDW.DW/. >=65 Years A0BÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‹mRNA-1273-P301 mRNA-1273-P301-US334-2046US3342046US334USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DVžDV|HrDVžHr1Ü4DVžHr1Ü4......DWDWDV|DW..DV|DW.. >=18 and <65 Years and Not at RiskABoNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BcmRNA-1273-P301 mRNA-1273-P301-US334-2046US3342046US334USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DVžDV|HrDVžHr1Ü4DVžHr1Ü4......DWDWDV|DW..DV|DW.. >=18 and <65 Years and Not at RiskABoNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BcBcmômRNA-1273-P301 mRNA-1273-P301-US334-2046US3342046US334USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DVžDV|HrDVžHr1Ü4DVžHr1Ü4......DWDWDV|DW..DV|DW.. >=18 and <65 Years and Not at RiskABoNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BcmôBcÛèmRNA-1273-P301 mRNA-1273-P301-US334-2048US3342048US334USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWKDV|Hr<DVžHr1ù€DVžHr1ù€DWKHsûäDWKHsûä...DW]DV|DWJDWK.DV|DWJDWK. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B˜mRNA-1273-P301 mRNA-1273-P301-US334-2048US3342048US334USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWKDV|Hr<DVžHr1ù€DVžHr1ù€DWKHsûäDWKHsûä...DW]DV|DWJDWK.DV|DWJDWK. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B˜B˜mðmRNA-1273-P301 mRNA-1273-P301-US334-2048US3342048US334USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWKDV|Hr<DVžHr1ù€DVžHr1ù€DWKHsûäDWKHsûä...DW]DV|DWJDWK.DV|DWJDWK. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B˜mðB˜ÛèmRNA-1273-P301 mRNA-1273-P301-US334-2131US3342131US334USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWEDVƒHr€hDV¦Hr<¶DV¦Hr<¶DWHrÚ°ÔDWEHsSÐDWEHsSÐ.DW]DVƒDWDW.DVƒDWDW. Severe Obesity >=18 and <65 Years and at Risk A B¸Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BgmRNA-1273-P301 mRNA-1273-P301-US334-2131US3342131US334USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWEDVƒHr€hDV¦Hr<¶DV¦Hr<¶DWHrÚ°ÔDWEHsSÐDWEHsSÐ.DW]DVƒDWDW.DVƒDWDW. Severe Obesity >=18 and <65 Years and at Risk A B¸Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BgBgmômRNA-1273-P301 mRNA-1273-P301-US334-2131US3342131US334USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWEDVƒHr€hDV¦Hr<¶DV¦Hr<¶DWHrÚ°ÔDWEHsSÐDWEHsSÐ.DW]DVƒDWDW.DVƒDWDW. Severe Obesity >=18 and <65 Years and at Risk A B¸Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BgmôBgÛèmRNA-1273-P301 mRNA-1273-P301-US334-2131US3342131US334USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWEDVƒHr€hDV¦Hr<¶DV¦Hr<¶DWHrÚ°ÔDWEHsSÐDWEHsSÐ.DW]DVƒDWDW.DVƒDWDW. Severe Obesity >=18 and <65 Years and at Risk A B¸Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BgÛèBgIÜmRNA-1273-P301 mRNA-1273-P301-US334-2146US3342146US334USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWHDV‰Hr‚ôDV§Hr>\DV§Hr>\DW"HràðDWHHsV`DWHHsV`.DW]DV‰DW!DW".DV‰DW!DW". >=18 and <65 Years and Not at RiskAB·Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BMmRNA-1273-P301 mRNA-1273-P301-US334-2152US3342152US334USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWFDV‹Hr@DV§Hr=ìDV§Hr=ìDWFHs¯(DWFHs¯(...DW]DV‹DWEDWF.DV‹DWEDWF. Diabetes >=18 and <65 Years and at Risk A B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB|mRNA-1273-P301 mRNA-1273-P301-US334-2152US3342152US334USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWFDV‹Hr@DV§Hr=ìDV§Hr=ìDWFHs¯(DWFHs¯(...DW]DV‹DWEDWF.DV‹DWEDWF. Diabetes >=18 and <65 Years and at Risk A B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB|B|mômRNA-1273-P301 mRNA-1273-P301-US334-2182US3342182US334USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DWFDV‘Hr öXDV»HrXnlDV»HrXnlDWFHs°DWFHs°...DW]DV‘DW(DW).DV‘DWEDWF. >=65 Years A0B£Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBƒmRNA-1273-P301 mRNA-1273-P301-US334-2182US3342182US334USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DWFDV‘Hr öXDV»HrXnlDV»HrXnlDWFHs°DWFHs°...DW]DV‘DW(DW).DV‘DWEDWF. >=65 Years A0B£Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBƒBƒmðmRNA-1273-P301 mRNA-1273-P301-US335-2071US3352071US335USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW9DV|Hr/hDV–Hr'cäDV–Hr'cäDWHrÒ»,DW9Hrþ?ôDW9Hrþ?ô.DW]DV|DWDW.DV|DWDW. >=18 and <65 Years and Not at RiskABÈMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BvmRNA-1273-P301 mRNA-1273-P301-US335-2090US3352090US335USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW/DV|Hrd$DV–Hr'¢´DV–Hr'¢´DWHrÌg,DW/HrñXpDW/HrñXp.DW]DV|DWDW.DV|DWDW. >=18 and <65 Years and Not at RiskABÈMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BZmRNA-1273-P301 mRNA-1273-P301-US335-2188US3352188US335USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DW4DV…HrðŒDV¡Hr6tDV¡Hr6tDWHrÖúèDW4Hr÷ÈDW4Hr÷È.DW]DV…DWDW.DV…DWDW. >=18 and <65 Years and Not at RiskAB½Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BvmRNA-1273-P301 mRNA-1273-P301-US335-2245US3352245US335USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW4DVˆHrõtDV¡Hr5åDV¡Hr5åDWHrÒÑèDW4Hr÷¬èDW4Hr÷¬è.DW]DVˆDWDW.DVˆDWDW. >=18 and <65 Years and Not at RiskAB½Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BKmRNA-1273-P301 mRNA-1273-P301-US335-2261US3352261US335USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHrØDV¤Hr9ÑÜDV¤Hr9ÑÜ.......DW]DVˆDW!DW".DVˆDW!DW". >=18 and <65 Years and Not at RiskABºMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BZmRNA-1273-P301 mRNA-1273-P301-US335-2261US3352261US335USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHrØDV¤Hr9ÑÜDV¤Hr9ÑÜ.......DW]DVˆDW!DW".DVˆDW!DW". >=18 and <65 Years and Not at RiskABºMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BZBZmômRNA-1273-P301 mRNA-1273-P301-US335-2261US3352261US335USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV¤DVˆHrØDV¤Hr9ÑÜDV¤Hr9ÑÜ.......DW]DVˆDW!DW".DVˆDW!DW". >=18 and <65 Years and Not at RiskABºMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BZmôBZÛèmRNA-1273-P301 mRNA-1273-P301-US335-2307US3352307US335USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVDV«DVHrQxDV«HrC<DV«HrC<.......DW]DVDW8DW9DW\DVDW8DW9DW\ >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBomRNA-1273-P301 mRNA-1273-P301-US335-2307US3352307US335USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVDV«DVHrQxDV«HrC<DV«HrC<.......DW]DVDW8DW9DW\DVDW8DW9DW\ >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBoBomômRNA-1273-P301 mRNA-1273-P301-US336-2018US3362018US336USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW:DVrHq÷èøDVŽHrå|DVŽHrå|DWHrÈ;˜DW:Hrÿ¡(DW:Hrÿ¡(.DW]DVrDWDW.DVrDWDW. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B[mRNA-1273-P301 mRNA-1273-P301-US336-2018US3362018US336USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW:DVrHq÷èøDVŽHrå|DVŽHrå|DWHrÈ;˜DW:Hrÿ¡(DW:Hrÿ¡(.DW]DVrDWDW.DVrDWDW. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B[B[mômRNA-1273-P301 mRNA-1273-P301-US336-2018US3362018US336USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW:DVrHq÷èøDVŽHrå|DVŽHrå|DWHrÈ;˜DW:Hrÿ¡(DW:Hrÿ¡(.DW]DVrDWDW.DVrDWDW. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B[môB[ÛèmRNA-1273-P301 mRNA-1273-P301-US336-2018US3362018US336USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW:DVrHq÷èøDVŽHrå|DVŽHrå|DWHrÈ;˜DW:Hrÿ¡(DW:Hrÿ¡(.DW]DVrDWDW.DVrDWDW. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B[ÛèB[IÜmRNA-1273-P301 mRNA-1273-P301-US336-2039US3362039US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWTDVsHqù|TDVHrbDVHrbDW8Hrý*8DWTHs!ÀPDWTHs!ÀP.DW]DVsDWDW.DVsDW7DW8. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB mRNA-1273-P301 mRNA-1273-P301-US336-2039US3362039US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWTDVsHqù|TDVHrbDVHrbDW8Hrý*8DWTHs!ÀPDWTHs!ÀP.DW]DVsDWDW.DVsDW7DW8. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB B mðmRNA-1273-P301 mRNA-1273-P301-US336-2040US3362040US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW/DVsHqù@DV–Hr'1øDV–Hr'1øDWHrÎÃ(DW/HrñÄDW/HrñÄ.DW]DVsDWDW.DVsDWDW. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B[mRNA-1273-P301 mRNA-1273-P301-US336-2040US3362040US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW/DVsHqù@DV–Hr'1øDV–Hr'1øDWHrÎÃ(DW/HrñÄDW/HrñÄ.DW]DVsDWDW.DVsDWDW. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B[B[mômRNA-1273-P301 mRNA-1273-P301-US336-2040US3362040US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW/DVsHqù@DV–Hr'1øDV–Hr'1øDWHrÎÃ(DW/HrñÄDW/HrñÄ.DW]DVsDWDW.DVsDWDW. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B[môB[ÛèmRNA-1273-P301 mRNA-1273-P301-US336-2040US3362040US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW/DVsHqù@DV–Hr'1øDV–Hr'1øDWHrÎÃ(DW/HrñÄDW/HrñÄ.DW]DVsDWDW.DVsDWDW. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B[ÛèB[IÜmRNA-1273-P301 mRNA-1273-P301-US336-2046US3362046US336USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW=DVtHqú{TDV–Hr'ŽDV–Hr'ŽDW=HspdDW=Hspd...DW]DVtDW<DW=.DVtDW<DW=. Diabetes >=18 and <65 Years and at Risk A BÈNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBvmRNA-1273-P301 mRNA-1273-P301-US336-2046US3362046US336USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW=DVtHqú{TDV–Hr'ŽDV–Hr'ŽDW=HspdDW=Hspd...DW]DVtDW<DW=.DVtDW<DW=. Diabetes >=18 and <65 Years and at Risk A BÈNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBvBvmômRNA-1273-P301 mRNA-1273-P301-US336-2055US3362055US336USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWVDVtHqúÝˆDV–Hr'“ðDV–Hr'“ðDW:HrÿcüDWVHs$OÜDWVHs$OÜ.DW]DVtDW9DW:.DVtDW9DW:. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BœmRNA-1273-P301 mRNA-1273-P301-US336-2055US3362055US336USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWVDVtHqúÝˆDV–Hr'“ðDV–Hr'“ðDW:HrÿcüDWVHs$OÜDWVHs$OÜ.DW]DVtDW9DW:.DVtDW9DW:. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BœBœmðmRNA-1273-P301 mRNA-1273-P301-US336-2055US3362055US336USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWVDVtHqúÝˆDV–Hr'“ðDV–Hr'“ðDW:HrÿcüDWVHs$OÜDWVHs$OÜ.DW]DVtDW9DW:.DVtDW9DW:. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BœmðBœÛèmRNA-1273-P301 mRNA-1273-P301-US336-2055US3362055US336USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWVDVtHqúÝˆDV–Hr'“ðDV–Hr'“ðDW:HrÿcüDWVHs$OÜDWVHs$OÜ.DW]DVtDW9DW:.DVtDW9DW:. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BœÛèBœIØmRNA-1273-P301 mRNA-1273-P301-US336-2061US3362061US336USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW?DVuHqûßDV—Hr(ÜDV—Hr(ÜDWHrÚÍ0DW?HsLDW?HsL.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB‚mRNA-1273-P301 mRNA-1273-P301-US336-2061US3362061US336USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW?DVuHqûßDV—Hr(ÜDV—Hr(ÜDWHrÚÍ0DW?HsLDW?HsL.DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB‚B‚mðmRNA-1273-P301 mRNA-1273-P301-US336-2082US3362082US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWODVvHqýDV’Hr"(èDV’Hr"(èDWOHs^ôDWOHs^ô...DW]DVvDWNDWO.DVvDWNDWO. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B™mRNA-1273-P301 mRNA-1273-P301-US336-2082US3362082US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWODVvHqýDV’Hr"(èDV’Hr"(èDWOHs^ôDWOHs^ô...DW]DVvDWNDWO.DVvDWNDWO. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B™B™mðmRNA-1273-P301 mRNA-1273-P301-US336-2082US3362082US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWODVvHqýDV’Hr"(èDV’Hr"(èDWOHs^ôDWOHs^ô...DW]DVvDWNDWO.DVvDWNDWO. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B™mðB™ÛèmRNA-1273-P301 mRNA-1273-P301-US336-2082US3362082US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWODVvHqýDV’Hr"(èDV’Hr"(èDWOHs^ôDWOHs^ô...DW]DVvDWNDWO.DVvDWNDWO. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B™ÛèB™IØmRNA-1273-P301 mRNA-1273-P301-US336-2133US3362133US336USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWVDV|Hro DVHr0Õ´DVHr0Õ´DW3Hrö|ìDWVHs$¯ôDWVHs$¯ô.DW]DV|DW2DW3.DV|DW2DW3. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmRNA-1273-P301 mRNA-1273-P301-US336-2133US3362133US336USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWVDV|Hro DVHr0Õ´DVHr0Õ´DW3Hrö|ìDWVHs$¯ôDWVHs$¯ô.DW]DV|DW2DW3.DV|DW2DW3. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBmðmRNA-1273-P301 mRNA-1273-P301-US336-2141US3362141US336USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWMDV}Hr‡xDV§Hr=¬XDV§Hr=¬XDW1HróÑ@DWMHs“hDWMHs“h.DW]DV}DW0DW1.DV}DW0DW1. Severe Obesity >=18 and <65 Years and at Risk A B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B’mRNA-1273-P301 mRNA-1273-P301-US336-2141US3362141US336USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWMDV}Hr‡xDV§Hr=¬XDV§Hr=¬XDW1HróÑ@DWMHs“hDWMHs“h.DW]DV}DW0DW1.DV}DW0DW1. Severe Obesity >=18 and <65 Years and at Risk A B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B’B’mðmRNA-1273-P301 mRNA-1273-P301-US336-2141US3362141US336USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWMDV}Hr‡xDV§Hr=¬XDV§Hr=¬XDW1HróÑ@DWMHs“hDWMHs“h.DW]DV}DW0DW1.DV}DW0DW1. Severe Obesity >=18 and <65 Years and at Risk A B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B’mðB’ÛèmRNA-1273-P301 mRNA-1273-P301-US336-2141US3362141US336USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWMDV}Hr‡xDV§Hr=¬XDV§Hr=¬XDW1HróÑ@DWMHs“hDWMHs“h.DW]DV}DW0DW1.DV}DW0DW1. Severe Obesity >=18 and <65 Years and at Risk A B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B’ÛèB’IØmRNA-1273-P301 mRNA-1273-P301-US336-2142US3362142US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWDDV}HrDDV£Hr8³°DV£Hr8³°DW#HráD”DWDHs°üDWDHs°ü.DW]DV}DW"DW#.DV}DW"DW#. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BtmRNA-1273-P301 mRNA-1273-P301-US336-2142US3362142US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWDDV}HrDDV£Hr8³°DV£Hr8³°DW#HráD”DWDHs°üDWDHs°ü.DW]DV}DW"DW#.DV}DW"DW#. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BtBtmômRNA-1273-P301 mRNA-1273-P301-US336-2142US3362142US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWDDV}HrDDV£Hr8³°DV£Hr8³°DW#HráD”DWDHs°üDWDHs°ü.DW]DV}DW"DW#.DV}DW"DW#. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BtmôBtÛèmRNA-1273-P301 mRNA-1273-P301-US336-2142US3362142US336USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWDDV}HrDDV£Hr8³°DV£Hr8³°DW#HráD”DWDHs°üDWDHs°ü.DW]DV}DW"DW#.DV}DW"DW#. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BtÛèBtIÜmRNA-1273-P301 mRNA-1273-P301-US336-2153US3362153US336USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DWVDV—Hr(’<DV³HrMxDV³HrMxDW:HrÿtdDWVHs$¦DWVHs$¦.DW]DV—DW9DW:.DV—DW9DW:. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BwmRNA-1273-P301 mRNA-1273-P301-US336-2153US3362153US336USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DWVDV—Hr(’<DV³HrMxDV³HrMxDW:HrÿtdDWVHs$¦DWVHs$¦.DW]DV—DW9DW:.DV—DW9DW:. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BwBwmômRNA-1273-P301 mRNA-1273-P301-US336-2153US3362153US336USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DWVDV—Hr(’<DV³HrMxDV³HrMxDW:HrÿtdDWVHs$¦DWVHs$¦.DW]DV—DW9DW:.DV—DW9DW:. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BwmôBwÛèmRNA-1273-P301 mRNA-1273-P301-US336-2168US3362168US336USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWYDV€Hr DäDVœHr/(ÌDVœHr/(ÌDW:HrÿnLDWYHs(VhDWYHs(Vh.DW]DV€DW9DW:.DV€DW9DW:. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US336-2168US3362168US336USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWYDV€Hr DäDVœHr/(ÌDVœHr/(ÌDW:HrÿnLDWYHs(VhDWYHs(Vh.DW]DV€DW9DW:.DV€DW9DW:. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmðmRNA-1273-P301 mRNA-1273-P301-US336-2168US3362168US336USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWYDV€Hr DäDVœHr/(ÌDVœHr/(ÌDW:HrÿnLDWYHs(VhDWYHs(Vh.DW]DV€DW9DW:.DV€DW9DW:. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US336-2227US3362227US336USABWYEARS>=65 Years A0>=65 Years A >=75 Years A0>=85 Years A@ .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWKDV…HrDV£Hr8…„DV£Hr8…„DW1Hró¡¬DWKHs1ÌDWKHs1Ì.DW]DV…DW0DW1.DV…DW0DW1. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‹mRNA-1273-P301 mRNA-1273-P301-US336-2281US3362281US336USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW3DV™Hr+%ˆDV¼HrYN|DV¼HrYN|DWHrÕ3DW3Hrö)@DW3Hrö)@.DW]DV™DWDW.DV™DWDW. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B¢Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BImRNA-1273-P301 mRNA-1273-P301-US336-2281US3362281US336USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW3DV™Hr+%ˆDV¼HrYN|DV¼HrYN|DWHrÕ3DW3Hrö)@DW3Hrö)@.DW]DV™DWDW.DV™DWDW. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B¢Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BIBImômRNA-1273-P301 mRNA-1273-P301-US336-2281US3362281US336USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW3DV™Hr+%ˆDV¼HrYN|DV¼HrYN|DWHrÕ3DW3Hrö)@DW3Hrö)@.DW]DV™DWDW.DV™DWDW. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B¢Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BImôBIÛèmRNA-1273-P301 mRNA-1273-P301-US336-2281US3362281US336USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW3DV™Hr+%ˆDV¼HrYN|DV¼HrYN|DWHrÕ3DW3Hrö)@DW3Hrö)@.DW]DV™DWDW.DV™DWDW. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B¢Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BIÛèBIIÜmRNA-1273-P301 mRNA-1273-P301-US336-2283US3362283US336USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWVDV™Hr+jèDV¹HrUƒxDV¹HrUƒxDW3Hrö]„DWVHs$„˜DWVHs$„˜.DW]DV™DW DW.DV™DW2DW3. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BsmRNA-1273-P301 mRNA-1273-P301-US336-2283US3362283US336USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWVDV™Hr+jèDV¹HrUƒxDV¹HrUƒxDW3Hrö]„DWVHs$„˜DWVHs$„˜.DW]DV™DW DW.DV™DW2DW3. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BsBsmômRNA-1273-P301 mRNA-1273-P301-US336-2283US3362283US336USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWVDV™Hr+jèDV¹HrUƒxDV¹HrUƒxDW3Hrö]„DWVHs$„˜DWVHs$„˜.DW]DV™DW DW.DV™DW2DW3. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BsmôBsÛèmRNA-1273-P301 mRNA-1273-P301-US336-2283US3362283US336USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWVDV™Hr+jèDV¹HrUƒxDV¹HrUƒxDW3Hrö]„DWVHs$„˜DWVHs$„˜.DW]DV™DW DW.DV™DW2DW3. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BsÛèBsIÜmRNA-1273-P301 mRNA-1273-P301-US337-2058US3372058US337USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW8DVvHqý$lDV’Hr"SÌDV’Hr"SÌDWHrÕ’¬DW8Hrý ÐDW8Hrý Ð.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BƒmRNA-1273-P301 mRNA-1273-P301-US337-2058US3372058US337USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW8DVvHqý$lDV’Hr"SÌDV’Hr"SÌDWHrÕ’¬DW8Hrý ÐDW8Hrý Ð.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BƒBƒmðmRNA-1273-P301 mRNA-1273-P301-US337-2058US3372058US337USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW8DVvHqý$lDV’Hr"SÌDV’Hr"SÌDWHrÕ’¬DW8Hrý ÐDW8Hrý Ð.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BƒmðBƒÛèmRNA-1273-P301 mRNA-1273-P301-US337-2138US3372138US337USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWHDV€Hr R@DV£Hr8oDV£Hr8oDW+Hrë¼äDWHHs÷tDWHHs÷t.DW]DV€DW*DW+.DV€DW*DW+. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B†mRNA-1273-P301 mRNA-1273-P301-US337-2138US3372138US337USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWHDV€Hr R@DV£Hr8oDV£Hr8oDW+Hrë¼äDWHHs÷tDWHHs÷t.DW]DV€DW*DW+.DV€DW*DW+. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B†B†mðmRNA-1273-P301 mRNA-1273-P301-US337-2138US3372138US337USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWHDV€Hr R@DV£Hr8oDV£Hr8oDW+Hrë¼äDWHHs÷tDWHHs÷t.DW]DV€DW*DW+.DV€DW*DW+. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B†mðB†ÛèmRNA-1273-P301 mRNA-1273-P301-US337-2189US3372189US337USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW[DVƒHrZ¬DV£Hr8vüDV£Hr8vüDW=HsyDW[Hs*û„DW[Hs*û„.DW]DVƒDW<DW=.DVƒDW<DW=. >=18 and <65 Years and Not at RiskAB»Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B{mRNA-1273-P301 mRNA-1273-P301-US337-2189US3372189US337USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW[DVƒHrZ¬DV£Hr8vüDV£Hr8vüDW=HsyDW[Hs*û„DW[Hs*û„.DW]DVƒDW<DW=.DVƒDW<DW=. >=18 and <65 Years and Not at RiskAB»Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B{B{mômRNA-1273-P301 mRNA-1273-P301-US337-2189US3372189US337USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW[DVƒHrZ¬DV£Hr8vüDV£Hr8vüDW=HsyDW[Hs*û„DW[Hs*û„.DW]DVƒDW<DW=.DVƒDW<DW=. >=18 and <65 Years and Not at RiskAB»Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B{môB{ÛèmRNA-1273-P301 mRNA-1273-P301-US337-2237US3372237US337USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWHDVˆHrñðDV¤Hr: dDV¤Hr: dDW,Hrí èDWHHs9ŒDWHHs9Œ.DW]DVˆDW+DW,.DVˆDW+DW,. >=18 and <65 Years and Not at RiskABºMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBHmRNA-1273-P301 mRNA-1273-P301-US337-2237US3372237US337USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDWHDVˆHrñðDV¤Hr: dDV¤Hr: dDW,Hrí èDWHHs9ŒDWHHs9Œ.DW]DVˆDW+DW,.DVˆDW+DW,. >=18 and <65 Years and Not at RiskABºMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBHBHmômRNA-1273-P301 mRNA-1273-P301-US337-2284US3372284US337USAB7YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DW@DV‹HrãdDVªHrAÔ¤DVªHrAÔ¤DW$HrâìDW@HsiDW@Hsi.DW]DV‹DW#DW$.DV‹DW#DW$. Severe Obesity >=18 and <65 Years and at Risk A B´Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBamRNA-1273-P301 mRNA-1273-P301-US337-2284US3372284US337USAB7YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DW@DV‹HrãdDVªHrAÔ¤DVªHrAÔ¤DW$HrâìDW@HsiDW@Hsi.DW]DV‹DW#DW$.DV‹DW#DW$. Severe Obesity >=18 and <65 Years and at Risk A B´Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBaBamômRNA-1273-P301 mRNA-1273-P301-US337-2290US3372290US337USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWSDV‹Hr)ðDV®HrG(<DV®HrG(<DW)HréN DWSHs ÆxDWSHs Æx.DW]DV‹DW(DW).DV‹DW(DW). >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBDmRNA-1273-P301 mRNA-1273-P301-US337-2290US3372290US337USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWSDV‹Hr)ðDV®HrG(<DV®HrG(<DW)HréN DWSHs ÆxDWSHs Æx.DW]DV‹DW(DW).DV‹DW(DW). >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBDBDmômRNA-1273-P301 mRNA-1273-P301-US337-2390US3372390US337USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DW6DV˜Hr*?ØDV»HrX`˜DV»HrX`˜DWHrÕ^,DW6Hrú7ˆDW6Hrú7ˆ.DW]DV˜DWDW.DV˜DWDW. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B_mRNA-1273-P301 mRNA-1273-P301-US338-2016US3382016US338USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW0DVzHrÉXDV–Hr'¦°DV–Hr'¦°DWHrÉƒ@DW0Hròa„DW0Hròa„.DW]DVzDWDW.DVzDWDW. >=18 and <65 Years and Not at RiskABÈMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmRNA-1273-P301 mRNA-1273-P301-US338-2096US3382096US338USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWDDV‡Hr‹ÐDV¥Hr;[`DV¥Hr;[`DWDHsõ0DWDHsõ0...DW]DV‡DWCDWD.DV‡DWCDWD. >=18 and <65 Years and Not at RiskAB¹Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB‘mRNA-1273-P301 mRNA-1273-P301-US338-2096US3382096US338USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWDDV‡Hr‹ÐDV¥Hr;[`DV¥Hr;[`DWDHsõ0DWDHsõ0...DW]DV‡DWCDWD.DV‡DWCDWD. >=18 and <65 Years and Not at RiskAB¹Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB‘B‘mðmRNA-1273-P301 mRNA-1273-P301-US338-2097US3382097US338USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW=DV‡Hr±ÈDVªHrAÄxDVªHrAÄxDWHr×úØDW=HszxDW=Hszx.DW]DV‡DWDW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BimRNA-1273-P301 mRNA-1273-P301-US338-2097US3382097US338USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW=DV‡Hr±ÈDVªHrAÄxDVªHrAÄxDWHr×úØDW=HszxDW=Hszx.DW]DV‡DWDW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BiBimômRNA-1273-P301 mRNA-1273-P301-US338-2097US3382097US338USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW=DV‡Hr±ÈDVªHrAÄxDVªHrAÄxDWHr×úØDW=HszxDW=Hszx.DW]DV‡DWDW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BimôBiÛèmRNA-1273-P301 mRNA-1273-P301-US338-2152US3382152US338USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVŽDV®DVŽHrœDV®HrG+üDV®HrG+ü.......DW]DVŽDVá..DVŽDVá.. >=18 and <65 Years and Not at RiskAB4Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B?mRNA-1273-P301 mRNA-1273-P301-US338-2152US3382152US338USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVŽDV®DVŽHrœDV®HrG+üDV®HrG+ü.......DW]DVŽDVá..DVŽDVá.. >=18 and <65 Years and Not at RiskAB4Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B?B?mômRNA-1273-P301 mRNA-1273-P301-US338-2152US3382152US338USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVŽDV®DVŽHrœDV®HrG+üDV®HrG+ü.......DW]DVŽDVá..DVŽDVá.. >=18 and <65 Years and Not at RiskAB4Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B?môB?ÛæmRNA-1273-P301 mRNA-1273-P301-US338-2235US3382235US338USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV˜DVµDV˜Hr)ùˆDVµHrPg¨DVµHrPg¨.......DW]DV˜DWDW.DV˜DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBUmRNA-1273-P301 mRNA-1273-P301-US338-2235US3382235US338USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV˜DVµDV˜Hr)ùˆDVµHrPg¨DVµHrPg¨.......DW]DV˜DWDW.DV˜DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBUBUmômRNA-1273-P301 mRNA-1273-P301-US338-2256US3382256US338USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYYYYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWDDVšHr,‘ÀDV¸HrT˜DV¸HrT˜DWDHs¬DWDHs¬...DW]DVšDWCDWD.DVšDWCDWD. Severe Obesity >=18 and <65 Years and at Risk A B¦Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BumRNA-1273-P301 mRNA-1273-P301-US338-2256US3382256US338USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYYYYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWDDVšHr,‘ÀDV¸HrT˜DV¸HrT˜DWDHs¬DWDHs¬...DW]DVšDWCDWD.DVšDWCDWD. Severe Obesity >=18 and <65 Years and at Risk A B¦Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BuBumômRNA-1273-P301 mRNA-1273-P301-US338-2256US3382256US338USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYYYYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWDDVšHr,‘ÀDV¸HrT˜DV¸HrT˜DWDHs¬DWDHs¬...DW]DVšDWCDWD.DVšDWCDWD. Severe Obesity >=18 and <65 Years and at Risk A B¦Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BumôBuÛèmRNA-1273-P301 mRNA-1273-P301-US338-2256US3382256US338USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYYYYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWDDVšHr,‘ÀDV¸HrT˜DV¸HrT˜DWDHs¬DWDHs¬...DW]DVšDWCDWD.DVšDWCDWD. Severe Obesity >=18 and <65 Years and at Risk A B¦Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BuÛèBuIÜmRNA-1273-P301 mRNA-1273-P301-US338-2281US3382281US338USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWDDVHr0˜LDV»HrXLDV»HrXLDWDHsÎÀDWDHsÎÀ...DW]DVDWCDWD.DVDWCDWD. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBzmRNA-1273-P301 mRNA-1273-P301-US338-2281US3382281US338USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWDDVHr0˜LDV»HrXLDV»HrXLDWDHsÎÀDWDHsÎÀ...DW]DVDWCDWD.DVDWCDWD. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBzBzmômRNA-1273-P301 mRNA-1273-P301-US339-2010US3392010US339USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWLDV|HrDVœHr/ZDVœHr/ZDW*Hrê~`DWLHsg¤DWLHsg¤.DW]DV|DW)DW*.DV|DW)DW*. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BtmRNA-1273-P301 mRNA-1273-P301-US339-2143US3392143US339USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW:DVHrgpDV¬HrD@DV¬HrD@DWHrÎÕèDW:Hrÿ˜|DW:Hrÿ˜|.DW]DVDWDW.DVDWDW. >=65 Years A0B²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B=mRNA-1273-P301 mRNA-1273-P301-US339-2184US3392184US339USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DW=DV—Hr(ÃìDV²HrLH€DV²HrLH€DW#HráK$DW=Hs¬dDW=Hs¬d.DW]DV—DW"DW#.DV—DW"DW#. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BomRNA-1273-P301 mRNA-1273-P301-US339-2253US3392253US339USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWDDVšHr,¹ÔDV¸HrTs\DV¸HrTs\DW+Hrì üDWDHs ôDWDHs ô.DW]DVšDW*DW+.DVšDW*DW+. >=18 and <65 Years and Not at RiskAB¦Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BSmRNA-1273-P301 mRNA-1273-P301-US339-2309US3392309US339USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWGDVŸHr3XÔDV»HrX>`DV»HrX>`DW+Hrëæ$DWGHsÍDWGHsÍ.DW]DVŸDW*DW+.DVŸDW*DW+. >=18 and <65 Years and Not at RiskAB£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBKmRNA-1273-P301 mRNA-1273-P301-US339-2309US3392309US339USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŸDWGDVŸHr3XÔDV»HrX>`DV»HrX>`DW+Hrëæ$DWGHsÍDWGHsÍ.DW]DVŸDW*DW+.DVŸDW*DW+. >=18 and <65 Years and Not at RiskAB£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBKBKmômRNA-1273-P301 mRNA-1273-P301-US339-2355US3392355US339USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWEDV®HrFþüDVÍHrp" DVÍHrp" DW*Hrêˆ°DWEHsDWEHs.DW]DV®DW)DW*.DV®DW)DW*. >=18 and <65 Years and Not at RiskAB‘Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BWmRNA-1273-P301 mRNA-1273-P301-US340-2001US3402001US340USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW(DVkHqî”tDV‡Hrt`DV‡Hrt`DWHrÃ<DW(Hrç³DW(Hrç³.DW]DVkDWDW.DVkDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBWmRNA-1273-P301 mRNA-1273-P301-US340-2001US3402001US340USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW(DVkHqî”tDV‡Hrt`DV‡Hrt`DWHrÃ<DW(Hrç³DW(Hrç³.DW]DVkDWDW.DVkDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBWBWmômRNA-1273-P301 mRNA-1273-P301-US340-2004US3402004US340USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW8DVkHqîœ0DV‡HrÉìDV‡HrÉìDWHrÏØDW8Hrý)HDW8Hrý)H.DW]DVkDW DW.DVkDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‹mRNA-1273-P301 mRNA-1273-P301-US340-2004US3402004US340USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW8DVkHqîœ0DV‡HrÉìDV‡HrÉìDWHrÏØDW8Hrý)HDW8Hrý)H.DW]DVkDW DW.DVkDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‹B‹mðmRNA-1273-P301 mRNA-1273-P301-US340-2004US3402004US340USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDW8DVkHqîœ0DV‡HrÉìDV‡HrÉìDWHrÏØDW8Hrý)HDW8Hrý)H.DW]DVkDW DW.DVkDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‹mðB‹ÛèmRNA-1273-P301 mRNA-1273-P301-US340-2030US3402030US340USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVkDWADVkHqï ÜDV‡HråÐDV‡HråÐDW$Hrâ¨ DWAHs ÈDWAHs È.DW]DVkDW DW.DVkDW#DW$. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BòmRNA-1273-P301 mRNA-1273-P301-US340-2094US3402094US340USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW>DVmHqñ±TDV‰Hr`DV‰Hr`DWHrÕL˜DW>Hs¿DW>Hs¿.DW]DVmDW DW.DVmDWDW. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÕNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BAmRNA-1273-P301 mRNA-1273-P301-US340-2094US3402094US340USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW>DVmHqñ±TDV‰Hr`DV‰Hr`DWHrÕL˜DW>Hs¿DW>Hs¿.DW]DVmDW DW.DVmDWDW. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÕNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BABAmômRNA-1273-P301 mRNA-1273-P301-US340-2094US3402094US340USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW>DVmHqñ±TDV‰Hr`DV‰Hr`DWHrÕL˜DW>Hs¿DW>Hs¿.DW]DVmDW DW.DVmDWDW. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÕNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BAmôBAÛèmRNA-1273-P301 mRNA-1273-P301-US340-2094US3402094US340USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW>DVmHqñ±TDV‰Hr`DV‰Hr`DWHrÕL˜DW>Hs¿DW>Hs¿.DW]DVmDW DW.DVmDWDW. Significant Cardiac DiseaseSevere Obesity >=18 and <65 Years and at Risk A BÕNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BAÛèBAIÜmRNA-1273-P301 mRNA-1273-P301-US340-2196US3402196US340USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW>DVrHq÷ÃDVŽHr§`DVŽHr§`DW"HrßÐdDW>HsÂ˜DW>HsÂ˜.DW]DVrDW DW.DVrDW!DW". >=65 Years A0BÐNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B•mRNA-1273-P301 mRNA-1273-P301-US340-2196US3402196US340USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW>DVrHq÷ÃDVŽHr§`DVŽHr§`DW"HrßÐdDW>HsÂ˜DW>HsÂ˜.DW]DVrDW DW.DVrDW!DW". >=65 Years A0BÐNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B•B•mðmRNA-1273-P301 mRNA-1273-P301-US340-2196US3402196US340USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW>DVrHq÷ÃDVŽHr§`DVŽHr§`DW"HrßÐdDW>HsÂ˜DW>HsÂ˜.DW]DVrDW DW.DVrDW!DW". >=65 Years A0BÐNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B•mðB•ÛèmRNA-1273-P301 mRNA-1273-P301-US340-2196US3402196US340USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW>DVrHq÷ÃDVŽHr§`DVŽHr§`DW"HrßÐdDW>HsÂ˜DW>HsÂ˜.DW]DVrDW DW.DVrDW!DW". >=65 Years A0BÐNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B•ÛèB•IØmRNA-1273-P301 mRNA-1273-P301-US340-2316US3402316US340USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVxDV™DVxHqÿëüDV™Hr+ŒäDV™Hr+Œä.......DW]DVxDW DW.DVxDW DW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BBmRNA-1273-P301 mRNA-1273-P301-US340-2316US3402316US340USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVxDV™DVxHqÿëüDV™Hr+ŒäDV™Hr+Œä.......DW]DVxDW DW.DVxDW DW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBBBmômRNA-1273-P301 mRNA-1273-P301-US340-2316US3402316US340USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVxDV™DVxHqÿëüDV™Hr+ŒäDV™Hr+Œä.......DW]DVxDW DW.DVxDW DW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BBmôBBÛèmRNA-1273-P301 mRNA-1273-P301-US340-2328US3402328US340USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWNDVzHrPàDVHr0{xDVHr0{xDW(HrçÝ¸DWNHsÌˆDWNHsÌˆ.DW]DVzDW DW.DVzDW'DW(. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‹mRNA-1273-P301 mRNA-1273-P301-US340-2332US3402332US340USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV{DVDV{Hr¼ DVHr0rDVHr0r.......DW]DV{DVì..DV{DVì.. >=18 and <65 Years and Not at RiskABPNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BqmRNA-1273-P301 mRNA-1273-P301-US340-2358US3402358US340USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWKDV~HrÑxDV Hr4uÔDV Hr4uÔDW"HrßÐdDWKHsÜDWKHsÜ.DW]DV~DW DW.DV~DW!DW". Severe Obesity >=18 and <65 Years and at Risk A B¾Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B`mRNA-1273-P301 mRNA-1273-P301-US340-2358US3402358US340USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWKDV~HrÑxDV Hr4uÔDV Hr4uÔDW"HrßÐdDWKHsÜDWKHsÜ.DW]DV~DW DW.DV~DW!DW". Severe Obesity >=18 and <65 Years and at Risk A B¾Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B`B`mômRNA-1273-P301 mRNA-1273-P301-US340-2358US3402358US340USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWKDV~HrÑxDV Hr4uÔDV Hr4uÔDW"HrßÐdDWKHsÜDWKHsÜ.DW]DV~DW DW.DV~DW!DW". Severe Obesity >=18 and <65 Years and at Risk A B¾Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B`môB`ÛèmRNA-1273-P301 mRNA-1273-P301-US340-2408US3402408US340USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWKDV„HrÃØDV¥Hr;2\DV¥Hr;2\DW#HráŽ,DWKHs4œDWKHs4œ.DW]DV„DW DW.DV„DW"DW#. >=18 and <65 Years and Not at RiskAB¹Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BfmRNA-1273-P301 mRNA-1273-P301-US340-2415US3402415US340USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DW6DV…HrÊDV£Hr8uXDV£Hr8uXDWHrÕzLDW6Hrú2œDW6Hrú2œ.DW]DV…DW DW.DV…DWDW. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBOmRNA-1273-P301 mRNA-1273-P301-US340-2415US3402415US340USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DW6DV…HrÊDV£Hr8uXDV£Hr8uXDWHrÕzLDW6Hrú2œDW6Hrú2œ.DW]DV…DW DW.DV…DWDW. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBOBOmômRNA-1273-P301 mRNA-1273-P301-US341-2012US3412012US341USAB.YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW@DVmHqñl¨DV‰Hr<àDV‰Hr<àDW@Hs”xDW@Hs”x...DW]DVmDW!DW".DVmDW?DW@. Severe Obesity >=18 and <65 Years and at Risk A BÕNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B˜mRNA-1273-P301 mRNA-1273-P301-US341-2012US3412012US341USAB.YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW@DVmHqñl¨DV‰Hr<àDV‰Hr<àDW@Hs”xDW@Hs”x...DW]DVmDW!DW".DVmDW?DW@. Severe Obesity >=18 and <65 Years and at Risk A BÕNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B˜B˜mðmRNA-1273-P301 mRNA-1273-P301-US341-2012US3412012US341USAB.YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW@DVmHqñl¨DV‰Hr<àDV‰Hr<àDW@Hs”xDW@Hs”x...DW]DVmDW!DW".DVmDW?DW@. Severe Obesity >=18 and <65 Years and at Risk A BÕNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B˜mðB˜ÛèmRNA-1273-P301 mRNA-1273-P301-US341-2012US3412012US341USAB.YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVmDW@DVmHqñl¨DV‰Hr<àDV‰Hr<àDW@Hs”xDW@Hs”x...DW]DVmDW!DW".DVmDW?DW@. Severe Obesity >=18 and <65 Years and at Risk A BÕNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B˜ÛèB˜IØmRNA-1273-P301 mRNA-1273-P301-US341-2108US3412108US341USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW*DVrHqø)¨DVŽHrÞìDVŽHrÞìDWHrÅÆÄDW*Hrê‘˜DW*Hrê‘˜.DW]DVrDW DW.DVrDW DW. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BëmRNA-1273-P301 mRNA-1273-P301-US341-2141US3412141US341USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWADVtHqú©€DVHr¶0DVHr¶0DW%HrãýœDWAHsÕÌDWAHsÕÌ.DW]DVtDWDW.DVtDW$DW%. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B˜mRNA-1273-P301 mRNA-1273-P301-US341-2208US3412208US341USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW+DVzHrÁ`DV–Hr'ElDV–Hr'ElDWHrÆÏ$DW+Hrë¸4DW+Hrë¸4.DW]DVzDWDW.DVzDWDW. >=65 Years A0BÈNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BymRNA-1273-P301 mRNA-1273-P301-US341-2208US3412208US341USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW+DVzHrÁ`DV–Hr'ElDV–Hr'ElDWHrÆÏ$DW+Hrë¸4DW+Hrë¸4.DW]DVzDWDW.DVzDWDW. >=65 Years A0BÈNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score ByBymômRNA-1273-P301 mRNA-1273-P301-US341-2208US3412208US341USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW+DVzHrÁ`DV–Hr'ElDV–Hr'ElDWHrÆÏ$DW+Hrë¸4DW+Hrë¸4.DW]DVzDWDW.DVzDWDW. >=65 Years A0BÈNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BymôByÛèmRNA-1273-P301 mRNA-1273-P301-US341-2208US3412208US341USABKYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW+DVzHrÁ`DV–Hr'ElDV–Hr'ElDWHrÆÏ$DW+Hrë¸4DW+Hrë¸4.DW]DVzDWDW.DVzDWDW. >=65 Years A0BÈNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score ByÛèByIÜmRNA-1273-P301 mRNA-1273-P301-US341-2224US3412224US341USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW0DV}Hr‚PDV™Hr+?ÈDV™Hr+?ÈDWHrÍ»|DW0HròdDW0Hròd.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BgmRNA-1273-P301 mRNA-1273-P301-US341-2224US3412224US341USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW0DV}Hr‚PDV™Hr+?ÈDV™Hr+?ÈDWHrÍ»|DW0HròdDW0Hròd.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BgBgmômRNA-1273-P301 mRNA-1273-P301-US341-2224US3412224US341USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW0DV}Hr‚PDV™Hr+?ÈDV™Hr+?ÈDWHrÍ»|DW0HròdDW0Hròd.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BgmôBgÛèmRNA-1273-P301 mRNA-1273-P301-US341-2245US3412245US341USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}Hr‡DV™Hr+RˆDV™Hr+Rˆ.......DW]DV}DWDWDWDV}DWDWDW >=18 and <65 Years and Not at RiskAB†Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B‚mRNA-1273-P301 mRNA-1273-P301-US341-2245US3412245US341USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}Hr‡DV™Hr+RˆDV™Hr+Rˆ.......DW]DV}DWDWDWDV}DWDWDW >=18 and <65 Years and Not at RiskAB†Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B‚B‚mðmRNA-1273-P301 mRNA-1273-P301-US341-2245US3412245US341USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}Hr‡DV™Hr+RˆDV™Hr+Rˆ.......DW]DV}DWDWDWDV}DWDWDW >=18 and <65 Years and Not at RiskAB†Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B‚mðB‚ÛèmRNA-1273-P301 mRNA-1273-P301-US341-2245US3412245US341USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}Hr‡DV™Hr+RˆDV™Hr+Rˆ.......DW]DV}DWDWDWDV}DWDWDW >=18 and <65 Years and Not at RiskAB†Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B‚ÛèB‚IØmRNA-1273-P301 mRNA-1273-P301-US341-2259US3412259US341USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW@DV€Hr ‰DV£Hr8hìDV£Hr8hìDWHrÕG¬DW@Hs^TDW@Hs^T.DW]DV€DWDW.DV€DWDW. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBTmRNA-1273-P301 mRNA-1273-P301-US341-2259US3412259US341USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW@DV€Hr ‰DV£Hr8hìDV£Hr8hìDWHrÕG¬DW@Hs^TDW@Hs^T.DW]DV€DWDW.DV€DWDW. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBTBTmômRNA-1273-P301 mRNA-1273-P301-US341-2270US3412270US341USABMYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW0DVHr¶¼DVHr08DVHr08DWHrÇ DW0Hrò‰ÔDW0Hrò‰Ô.DW]DVDWDW.DVDWDW.Chronic Lung Disease >=65 Years A0BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BMmRNA-1273-P301 mRNA-1273-P301-US341-2270US3412270US341USABMYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW0DVHr¶¼DVHr08DVHr08DWHrÇ DW0Hrò‰ÔDW0Hrò‰Ô.DW]DVDWDW.DVDWDW.Chronic Lung Disease >=65 Years A0BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BMBMmômRNA-1273-P301 mRNA-1273-P301-US341-2270US3412270US341USABMYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW0DVHr¶¼DVHr08DVHr08DWHrÇ DW0Hrò‰ÔDW0Hrò‰Ô.DW]DVDWDW.DVDWDW.Chronic Lung Disease >=65 Years A0BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BMmôBMÛèmRNA-1273-P301 mRNA-1273-P301-US341-2270US3412270US341USABMYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW0DVHr¶¼DVHr08DVHr08DWHrÇ DW0Hrò‰ÔDW0Hrò‰Ô.DW]DVDWDW.DVDWDW.Chronic Lung Disease >=65 Years A0BÁNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BMÛèBMIÜmRNA-1273-P301 mRNA-1273-P301-US341-2300US3412300US341USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW2DV‡Hro°DV£Hr8f”DV£Hr8f”DWHrÏö¨DW2HrôÜ4DW2HrôÜ4.DW]DV‡DWDW.DV‡DWDW. Severe Obesity >=18 and <65 Years and at Risk A B»Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BÖmRNA-1273-P301 mRNA-1273-P301-US341-2304US3412304US341USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW@DV‡HrŒüDV£Hr8`¸DV£Hr8`¸DWHrÕL˜DW@HsUlDW@HsUl.DW]DV‡DWDW.DV‡DWDW. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BImRNA-1273-P301 mRNA-1273-P301-US341-2304US3412304US341USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW@DV‡HrŒüDV£Hr8`¸DV£Hr8`¸DWHrÕL˜DW@HsUlDW@HsUl.DW]DV‡DWDW.DV‡DWDW. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BIBImômRNA-1273-P301 mRNA-1273-P301-US341-2304US3412304US341USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW@DV‡HrŒüDV£Hr8`¸DV£Hr8`¸DWHrÕL˜DW@HsUlDW@HsUl.DW]DV‡DWDW.DV‡DWDW. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BImôBIÛèmRNA-1273-P301 mRNA-1273-P301-US342-2087US3422087US342USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWZDV‡HrzDV£Hr8\€DV£Hr8\€DW=Hs_„DWZHs)›DWZHs)›.DW]DV‡DW DW.DV‡DW<DW=. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB…mRNA-1273-P301 mRNA-1273-P301-US342-2087US3422087US342USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWZDV‡HrzDV£Hr8\€DV£Hr8\€DW=Hs_„DWZHs)›DWZHs)›.DW]DV‡DW DW.DV‡DW<DW=. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB…B…mðmRNA-1273-P301 mRNA-1273-P301-US342-2144US3422144US342USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWZDV‹Hr8DV§Hr=ßèDV§Hr=ßèDW8HrüìXDWZHs)ÄDWZHs)Ä.DW]DV‹DW7DW8.DV‹DW7DW8. Severe Obesity >=18 and <65 Years and at Risk A B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBƒmRNA-1273-P301 mRNA-1273-P301-US342-2144US3422144US342USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DWZDV‹Hr8DV§Hr=ßèDV§Hr=ßèDW8HrüìXDWZHs)ÄDWZHs)Ä.DW]DV‹DW7DW8.DV‹DW7DW8. Severe Obesity >=18 and <65 Years and at Risk A B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBƒBƒmðmRNA-1273-P301 mRNA-1273-P301-US342-2149US3422149US342USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW8DVŽHr·DVªHrAš„DVªHrAš„DWHrÚÀDW8HrüÎXDW8HrüÎX.DW]DVŽDWDW.DVŽDWDW. >=18 and <65 Years and Not at RiskAB´Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B8mRNA-1273-P301 mRNA-1273-P301-US342-2149US3422149US342USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW8DVŽHr·DVªHrAš„DVªHrAš„DWHrÚÀDW8HrüÎXDW8HrüÎX.DW]DVŽDWDW.DVŽDWDW. >=18 and <65 Years and Not at RiskAB´Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B8B8mômRNA-1273-P301 mRNA-1273-P301-US342-2149US3422149US342USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW8DVŽHr·DVªHrAš„DVªHrAš„DWHrÚÀDW8HrüÎXDW8HrüÎX.DW]DVŽDWDW.DVŽDWDW. >=18 and <65 Years and Not at RiskAB´Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B8môB8ÛæmRNA-1273-P301 mRNA-1273-P301-US342-2168US3422168US342USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWLDVHrDV«HrCDV«HrCDWLHsApDWLHsAp...DW]DVDW DW.DVDWKDWL. >=18 and <65 Years and Not at RiskAB³Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BUmRNA-1273-P301 mRNA-1273-P301-US342-2168US3422168US342USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWLDVHrDV«HrCDV«HrCDWLHsApDWLHsAp...DW]DVDW DW.DVDWKDWL. >=18 and <65 Years and Not at RiskAB³Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BUBUmômRNA-1273-P301 mRNA-1273-P301-US342-2168US3422168US342USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWLDVHrDV«HrCDV«HrCDWLHsApDWLHsAp...DW]DVDW DW.DVDWKDWL. >=18 and <65 Years and Not at RiskAB³Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BUmôBUÛèmRNA-1273-P301 mRNA-1273-P301-US342-2168US3422168US342USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWLDVHrDV«HrCDV«HrCDWLHsApDWLHsAp...DW]DVDW DW.DVDWKDWL. >=18 and <65 Years and Not at RiskAB³Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BUÛèBUIÜmRNA-1273-P301 mRNA-1273-P301-US342-2201US3422201US342USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‘DVDV‘Hr Î¼DVHrE½0DVHrE½0.......DW]DV‘DWDWDWDV‘DWDWDW >=18 and <65 Years and Not at RiskABdNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BfmRNA-1273-P301 mRNA-1273-P301-US342-2201US3422201US342USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‘DVDV‘Hr Î¼DVHrE½0DVHrE½0.......DW]DV‘DWDWDWDV‘DWDWDW >=18 and <65 Years and Not at RiskABdNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BfBfmômRNA-1273-P301 mRNA-1273-P301-US342-2201US3422201US342USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‘DVDV‘Hr Î¼DVHrE½0DVHrE½0.......DW]DV‘DWDWDWDV‘DWDWDW >=18 and <65 Years and Not at RiskABdNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BfmôBfÛèmRNA-1273-P301 mRNA-1273-P301-US342-2276US3422276US342USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDW2DVœHr/ZDV¸HrT”DV¸HrT”DWHrÐ DW2HrôíÈDW2HrôíÈ.DW]DVœDW DW.DVœDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A B¦Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BXmRNA-1273-P301 mRNA-1273-P301-US342-2276US3422276US342USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDW2DVœHr/ZDV¸HrT”DV¸HrT”DWHrÐ DW2HrôíÈDW2HrôíÈ.DW]DVœDW DW.DVœDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A B¦Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BXBXmômRNA-1273-P301 mRNA-1273-P301-US342-2276US3422276US342USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDW2DVœHr/ZDV¸HrT”DV¸HrT”DWHrÐ DW2HrôíÈDW2HrôíÈ.DW]DVœDW DW.DVœDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A B¦Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BXmôBXÛèmRNA-1273-P301 mRNA-1273-P301-US342-2276US3422276US342USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDW2DVœHr/ZDV¸HrT”DV¸HrT”DWHrÐ DW2HrôíÈDW2HrôíÈ.DW]DVœDW DW.DVœDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A B¦Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BXÛèBXIÜmRNA-1273-P301 mRNA-1273-P301-US342-2311US3422311US342USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNNYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DWADV¬HrDSPDVÆHrfœ0DVÆHrfœ0DWHrÙDœDWAHs²hDWAHs²h.DW]DV¬DW DW.DV¬DWDW. >=18 and <65 Years and Not at RiskAB˜Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB!mRNA-1273-P301 mRNA-1273-P301-US342-2311US3422311US342USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNNYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DWADV¬HrDSPDVÆHrfœ0DVÆHrfœ0DWHrÙDœDWAHs²hDWAHs²h.DW]DV¬DW DW.DV¬DWDW. >=18 and <65 Years and Not at RiskAB˜Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB!B!mômRNA-1273-P301 mRNA-1273-P301-US343-2126US3432126US343USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW1DVƒHrJDDVŸHr3-xDVŸHr3-xDWHrÉ‹°DW1Hró·<DW1Hró·<.DW]DVƒDWDW.DVƒDWDW. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBXmRNA-1273-P301 mRNA-1273-P301-US343-2126US3432126US343USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW1DVƒHrJDDVŸHr3-xDVŸHr3-xDWHrÉ‹°DW1Hró·<DW1Hró·<.DW]DVƒDWDW.DVƒDWDW. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBXBXmômRNA-1273-P301 mRNA-1273-P301-US343-2146US3432146US343USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW\DV}HrˆàDV™Hr+BÔDV™Hr+BÔDW@HsˆDW\Hs,…DDW\Hs,…D.DW]DV}DWDW.DV}DW?DW@. Significant Cardiac Disease DiabetesLiver Disease >=65 Years A0BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B{mRNA-1273-P301 mRNA-1273-P301-US343-2266US3432266US343USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWFDV‡HrÉtDV¤Hr9Ä€DV¤Hr9Ä€DW+HrëË¨DWFHsbÀDWFHsbÀ.DW]DV‡DW*DW+.DV‡DW*DW+. >=18 and <65 Years and Not at RiskABºMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B~mRNA-1273-P301 mRNA-1273-P301-US343-2266US3432266US343USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWFDV‡HrÉtDV¤Hr9Ä€DV¤Hr9Ä€DW+HrëË¨DWFHsbÀDWFHsbÀ.DW]DV‡DW*DW+.DV‡DW*DW+. >=18 and <65 Years and Not at RiskABºMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B~B~mômRNA-1273-P301 mRNA-1273-P301-US343-2266US3432266US343USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWFDV‡HrÉtDV¤Hr9Ä€DV¤Hr9Ä€DW+HrëË¨DWFHsbÀDWFHsbÀ.DW]DV‡DW*DW+.DV‡DW*DW+. >=18 and <65 Years and Not at RiskABºMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B~môB~ÛèmRNA-1273-P301 mRNA-1273-P301-US343-2344US3432344US343USABMYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DW?DV‹HrÄDV§Hr=æ´DV§Hr=æ´DW#Hrá¤DW?HsS`DW?HsS`.DW]DV‹DW"DW#.DV‹DW"DW#.Chronic Lung Disease >=65 Years A0B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B1mRNA-1273-P301 mRNA-1273-P301-US343-2344US3432344US343USABMYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DW?DV‹HrÄDV§Hr=æ´DV§Hr=æ´DW#Hrá¤DW?HsS`DW?HsS`.DW]DV‹DW"DW#.DV‹DW"DW#.Chronic Lung Disease >=65 Years A0B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B1B1mômRNA-1273-P301 mRNA-1273-P301-US343-2344US3432344US343USABMYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DW?DV‹HrÄDV§Hr=æ´DV§Hr=æ´DW#Hrá¤DW?HsS`DW?HsS`.DW]DV‹DW"DW#.DV‹DW"DW#.Chronic Lung Disease >=65 Years A0B·Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B1môB1ÛæmRNA-1273-P301 mRNA-1273-P301-US343-2387US3432387US343USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWODVHrY¬DVHrE¡ˆDVHrE¡ˆDWOHsz`DWOHsz`...DW]DVDWDDWE.DVDWNDWO. >=18 and <65 Years and Not at RiskAB±Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BLmRNA-1273-P301 mRNA-1273-P301-US343-2416US3432416US343USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW?DV‘Hr Û(DVHrE—8DVHrE—8DW$HrâgpDW?HsüDW?Hsü.DW]DV‘DW#DW$.DV‘DW#DW$. >=18 and <65 Years and Not at RiskAB±Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB[mRNA-1273-P301 mRNA-1273-P301-US343-2416US3432416US343USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW?DV‘Hr Û(DVHrE—8DVHrE—8DW$HrâgpDW?HsüDW?Hsü.DW]DV‘DW#DW$.DV‘DW#DW$. >=18 and <65 Years and Not at RiskAB±Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB[B[mômRNA-1273-P301 mRNA-1273-P301-US343-2424US3432424US343USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWKDV’Hr!ùDV®HrFÔTDV®HrFÔTDW/Hrðô˜DWKHsôÜDWKHsôÜ.DW]DV’DW.DW/.DV’DW.DW/. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB{mRNA-1273-P301 mRNA-1273-P301-US343-2424US3432424US343USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWKDV’Hr!ùDV®HrFÔTDV®HrFÔTDW/Hrðô˜DWKHsôÜDWKHsôÜ.DW]DV’DW.DW/.DV’DW.DW/. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB{B{mômRNA-1273-P301 mRNA-1273-P301-US343-2431US3432431US343USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW>DV’Hr"/<DVHrEÜ˜DVHrEÜ˜DW#Hrá`<DW>Hså„DW>Hså„.DW]DV’DW"DW#.DV’DW"DW#. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBTmRNA-1273-P301 mRNA-1273-P301-US343-2431US3432431US343USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW>DV’Hr"/<DVHrEÜ˜DVHrEÜ˜DW#Hrá`<DW>Hså„DW>Hså„.DW]DV’DW"DW#.DV’DW"DW#. >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBTBTmômRNA-1273-P301 mRNA-1273-P301-US343-2521US3432521US343USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVŸDV¼DVŸHr3èDV¼HrYÁTDV¼HrYÁT......DW DW DVŸDWDWDW DVŸDWDWDW >=18 and <65 Years and Not at RiskABRMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BnmRNA-1273-P301 mRNA-1273-P301-US343-2642US3432642US343USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDWHDVÂHraž`DVÞHr†cÐDVÞHr†cÐDW-HrîMØDWHHsHŒDWHHsHŒ.DW]DVÂDW,DW-.DVÂDW,DW-. >=18 and <65 Years and Not at RiskAB€Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BOmRNA-1273-P301 mRNA-1273-P301-US343-2642US3432642US343USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDWHDVÂHraž`DVÞHr†cÐDVÞHr†cÐDW-HrîMØDWHHsHŒDWHHsHŒ.DW]DVÂDW,DW-.DVÂDW,DW-. >=18 and <65 Years and Not at RiskAB€Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BOBOmômRNA-1273-P301 mRNA-1273-P301-US343-2642US3432642US343USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDWHDVÂHraž`DVÞHr†cÐDVÞHr†cÐDW-HrîMØDWHHsHŒDWHHsHŒ.DW]DVÂDW,DW-.DVÂDW,DW-. >=18 and <65 Years and Not at RiskAB€Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BOmôBOÛèmRNA-1273-P301 mRNA-1273-P301-US344-2041US3442041US344USAB@YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYYYYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVƒDVŸDVƒHrsÀDVŸHr3œDVŸHr3œ.......DW]DVƒDW"DW#.DVƒDW"DW#. Significant Cardiac Disease >=18 and <65 Years and at Risk A B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B€mRNA-1273-P301 mRNA-1273-P301-US344-2065US3442065US344USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV„DV DV„HrälDV Hr4}ÌDV Hr4}Ì.......DW]DV„DWDWDWDV„DWDWDW >=18 and <65 Years and Not at RiskABfNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BYmRNA-1273-P301 mRNA-1273-P301-US344-2069US3442069US344USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW3DV„HrDDV¤Hr9µDV¤Hr9µDWHrÕ^,DW3Hrö@ìDW3Hrö@ì.DW]DV„DWDWDWNDV„DWDWDWN Diabetes >=18 and <65 Years and at Risk A B«Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BMmRNA-1273-P301 mRNA-1273-P301-US344-2096US3442096US344USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWADVŠHr˜8DV£Hr8‘xDV£Hr8‘xDW(Hrè)¨DWAHs àDWAHs à.DW]DVŠDW'DW(.DVŠDW'DW(. >=18 and <65 Years and Not at RiskAB»Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B{mRNA-1273-P301 mRNA-1273-P301-US344-2096US3442096US344USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWADVŠHr˜8DV£Hr8‘xDV£Hr8‘xDW(Hrè)¨DWAHs àDWAHs à.DW]DVŠDW'DW(.DVŠDW'DW(. >=18 and <65 Years and Not at RiskAB»Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B{B{mômRNA-1273-P301 mRNA-1273-P301-US344-2096US3442096US344USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWADVŠHr˜8DV£Hr8‘xDV£Hr8‘xDW(Hrè)¨DWAHs àDWAHs à.DW]DVŠDW'DW(.DVŠDW'DW(. >=18 and <65 Years and Not at RiskAB»Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B{môB{ÛèmRNA-1273-P301 mRNA-1273-P301-US344-2096US3442096US344USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWADVŠHr˜8DV£Hr8‘xDV£Hr8‘xDW(Hrè)¨DWAHs àDWAHs à.DW]DVŠDW'DW(.DVŠDW'DW(. >=18 and <65 Years and Not at RiskAB»Minority Non-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B{ÛèB{IÜmRNA-1273-P301 mRNA-1273-P301-US344-2122US3442122US344USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV‘DVªDV‘Hr!ÄDVªHrAÏ¸DVªHrAÏ¸.......DW]DV‘DWDW.DV‘DWDW. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBhmRNA-1273-P301 mRNA-1273-P301-US344-2122US3442122US344USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV‘DVªDV‘Hr!ÄDVªHrAÏ¸DVªHrAÏ¸.......DW]DV‘DWDW.DV‘DWDW. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBhBhmômRNA-1273-P301 mRNA-1273-P301-US344-2131US3442131US344USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWHDV’Hr"1DV®HrFöPDV®HrFöPDW,Hrí!œDWHHsœDWHHsœ.DW]DV’DW+DW,.DV’DW+DW,. >=18 and <65 Years and Not at RiskAB°Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BsmRNA-1273-P301 mRNA-1273-P301-US344-2163US3442163US344USABNYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW3DVHr0ètDVºHrVùLDVºHrVùLDWHrÍÌÔDW3HröŠÀDW3HröŠÀ.DW]DVDWDW.DVDWDW. Significant Cardiac Disease >=65 Years A0B¤Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B$mRNA-1273-P301 mRNA-1273-P301-US344-2163US3442163US344USABNYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW3DVHr0ètDVºHrVùLDVºHrVùLDWHrÍÌÔDW3HröŠÀDW3HröŠÀ.DW]DVDWDW.DVDWDW. Significant Cardiac Disease >=65 Years A0B¤Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B$B$mômRNA-1273-P301 mRNA-1273-P301-US344-2163US3442163US344USABNYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW3DVHr0ètDVºHrVùLDVºHrVùLDWHrÍÌÔDW3HröŠÀDW3HröŠÀ.DW]DVDWDW.DVDWDW. Significant Cardiac Disease >=65 Years A0B¤Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B$môB$ÛæmRNA-1273-P301 mRNA-1273-P301-US344-2163US3442163US344USABNYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW3DVHr0ètDVºHrVùLDVºHrVùLDWHrÍÌÔDW3HröŠÀDW3HröŠÀ.DW]DVDWDW.DVDWDW. Significant Cardiac Disease >=65 Years A0B¤Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B$ÛæB$IÚmRNA-1273-P301 mRNA-1273-P301-US344-2173US3442173US344USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW,DVžHr1÷dDV»HrX.pDV»HrX.pDWHrÌ"DW,Hrí àDW,Hrí à.DW]DVžDWDW.DVžDWDW.Chronic Lung Disease Diabetes >=18 and <65 Years and at Risk A B£Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBRmRNA-1273-P301 mRNA-1273-P301-US344-2173US3442173US344USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW,DVžHr1÷dDV»HrX.pDV»HrX.pDWHrÌ"DW,Hrí àDW,Hrí à.DW]DVžDWDW.DVžDWDW.Chronic Lung Disease Diabetes >=18 and <65 Years and at Risk A B£Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBRBRmômRNA-1273-P301 mRNA-1273-P301-US345-2035US3452035US345USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDW;DVnHqòÕ˜DV‡HrDDV‡HrDDWHrÎÇ`DW;Hsä˜DW;Hsä˜.DW]DVnDWDW.DVnDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BamRNA-1273-P301 mRNA-1273-P301-US345-2035US3452035US345USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDW;DVnHqòÕ˜DV‡HrDDV‡HrDDWHrÎÇ`DW;Hsä˜DW;Hsä˜.DW]DVnDWDW.DVnDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BaBamômRNA-1273-P301 mRNA-1273-P301-US345-2035US3452035US345USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDW;DVnHqòÕ˜DV‡HrDDV‡HrDDWHrÎÇ`DW;Hsä˜DW;Hsä˜.DW]DVnDWDW.DVnDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BamôBaÛèmRNA-1273-P301 mRNA-1273-P301-US345-2035US3452035US345USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDW;DVnHqòÕ˜DV‡HrDDV‡HrDDWHrÎÇ`DW;Hsä˜DW;Hsä˜.DW]DVnDWDW.DVnDWDW. >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BaÛèBaIÜmRNA-1273-P301 mRNA-1273-P301-US345-2041US3452041US345USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDWGDVnHqòôÄDV‡HrÜ4DV‡HrÜ4DW)Hrén¼DWGHs8DWGHs8.DW]DVnDW(DW).DVnDW(DW). >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B„mRNA-1273-P301 mRNA-1273-P301-US345-2041US3452041US345USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDWGDVnHqòôÄDV‡HrÜ4DV‡HrÜ4DW)Hrén¼DWGHs8DWGHs8.DW]DVnDW(DW).DVnDW(DW). >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B„B„mðmRNA-1273-P301 mRNA-1273-P301-US345-2041US3452041US345USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDWGDVnHqòôÄDV‡HrÜ4DV‡HrÜ4DW)Hrén¼DWGHs8DWGHs8.DW]DVnDW(DW).DVnDW(DW). >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B„mðB„ÛèmRNA-1273-P301 mRNA-1273-P301-US345-2041US3452041US345USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVnDWGDVnHqòôÄDV‡HrÜ4DV‡HrÜ4DW)Hrén¼DWGHs8DWGHs8.DW]DVnDW(DW).DVnDW(DW). >=18 and <65 Years and Not at RiskAB×Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B„ÛèB„IØmRNA-1273-P301 mRNA-1273-P301-US345-2102US3452102US345USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVpDV‹DVpHqõm”DV‹Hrí´DV‹Hrí´.......DW]DVp...DVp... >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB¤mRNA-1273-P301 mRNA-1273-P301-US345-2102US3452102US345USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVpDV‹DVpHqõm”DV‹Hrí´DV‹Hrí´.......DW]DVp...DVp... >=18 and <65 Years and Not at RiskABÓNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB¤B¤mðmRNA-1273-P301 mRNA-1273-P301-US345-2127US3452127US345USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVrDVŽDVrHq÷ÏlDVŽHr°„DVŽHr°„.......DW]DVrDWDW.DVrDWDW. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BGmRNA-1273-P301 mRNA-1273-P301-US345-2130US3452130US345USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDWMDVrHq÷ÛØDVŽHr»ÄDVŽHr»ÄDWMHsä¼DWMHsä¼...DW]DVrDWLDWM.DVrDWLDWM. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBjmRNA-1273-P301 mRNA-1273-P301-US345-2130US3452130US345USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDWMDVrHq÷ÛØDVŽHr»ÄDVŽHr»ÄDWMHsä¼DWMHsä¼...DW]DVrDWLDWM.DVrDWLDWM. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBjBjmômRNA-1273-P301 mRNA-1273-P301-US345-2168US3452168US345USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW?DVsHqù 8DVHrOˆDVHrOˆDW!HrÞ˜DW?Hs#DW?Hs#.DW]DVsDW DW!.DVsDW DW!. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BymRNA-1273-P301 mRNA-1273-P301-US345-2203US3452203US345USABPYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWLDVsHqùnDDV‘Hr îœDV‘Hr îœDWLHs|€DWLHs|€...DW]DVsDWKDWL.DVsDWKDWL. >=65 Years A0BÍNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBimRNA-1273-P301 mRNA-1273-P301-US345-2203US3452203US345USABPYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWLDVsHqùnDDV‘Hr îœDV‘Hr îœDWLHs|€DWLHs|€...DW]DVsDWKDWL.DVsDWKDWL. >=65 Years A0BÍNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBiBimômRNA-1273-P301 mRNA-1273-P301-US345-2212US3452212US345USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWFDVsHqù†àDVŽHrÇôDVŽHrÇôDW*HrêYXDWFHsWDWFHsW.DW]DVsDW)DW*.DVsDW)DW*. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BwmRNA-1273-P301 mRNA-1273-P301-US345-2212US3452212US345USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWFDVsHqù†àDVŽHrÇôDVŽHrÇôDW*HrêYXDWFHsWDWFHsW.DW]DVsDW)DW*.DVsDW)DW*. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BwBwmômRNA-1273-P301 mRNA-1273-P301-US345-2212US3452212US345USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWFDVsHqù†àDVŽHrÇôDVŽHrÇôDW*HrêYXDWFHsWDWFHsW.DW]DVsDW)DW*.DVsDW)DW*. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BwmôBwÛèmRNA-1273-P301 mRNA-1273-P301-US345-2212US3452212US345USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWFDVsHqù†àDVŽHrÇôDVŽHrÇôDW*HrêYXDWFHsWDWFHsW.DW]DVsDW)DW*.DVsDW)DW*. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BwÛèBwIÜmRNA-1273-P301 mRNA-1273-P301-US345-2232US3452232US345USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNNYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDV–DVtHqúlDV–Hr'F\DV–Hr'F\.......DW]DVtDW=..DVtDW=.. >=18 and <65 Years and Not at RiskAB¨Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B„mRNA-1273-P301 mRNA-1273-P301-US345-2232US3452232US345USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNNYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDV–DVtHqúlDV–Hr'F\DV–Hr'F\.......DW]DVtDW=..DVtDW=.. >=18 and <65 Years and Not at RiskAB¨Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B„B„mðmRNA-1273-P301 mRNA-1273-P301-US345-2232US3452232US345USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNNYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDV–DVtHqúlDV–Hr'F\DV–Hr'F\.......DW]DVtDW=..DVtDW=.. >=18 and <65 Years and Not at RiskAB¨Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B„mðB„ÛèmRNA-1273-P301 mRNA-1273-P301-US345-2232US3452232US345USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNNYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVtDV–DVtHqúlDV–Hr'F\DV–Hr'F\.......DW]DVtDW=..DVtDW=.. >=18 and <65 Years and Not at RiskAB¨Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B„ÛèB„IØmRNA-1273-P301 mRNA-1273-P301-US345-2278US3452278US345USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDWFDVuHqûüàDV—Hr(¢àDV—Hr(¢àDWFHsX4DWFHsX4...DW]DVuDWEDWF.DVuDWEDWF. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BtmRNA-1273-P301 mRNA-1273-P301-US345-2331US3452331US345USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqýkpDV‘Hr ÎDV‘Hr ÎDW)HréF¨DWFHswœDWFHswœ.DW]DVvDW(DW).DVvDW(DW). >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BPmRNA-1273-P301 mRNA-1273-P301-US345-2331US3452331US345USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqýkpDV‘Hr ÎDV‘Hr ÎDW)HréF¨DWFHswœDWFHswœ.DW]DVvDW(DW).DVvDW(DW). >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BPBPmômRNA-1273-P301 mRNA-1273-P301-US345-2331US3452331US345USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqýkpDV‘Hr ÎDV‘Hr ÎDW)HréF¨DWFHswœDWFHswœ.DW]DVvDW(DW).DVvDW(DW). >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BPmôBPÛèmRNA-1273-P301 mRNA-1273-P301-US345-2331US3452331US345USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqýkpDV‘Hr ÎDV‘Hr ÎDW)HréF¨DWFHswœDWFHswœ.DW]DVvDW(DW).DVvDW(DW). >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BPÛèBPIÜmRNA-1273-P301 mRNA-1273-P301-US345-2332US3452332US345USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqýlØDV‘Hr Î¼DV‘Hr Î¼DW)HréG˜DWFHsw$DWFHsw$.DW]DVvDW(DW).DVvDW(DW). Significant Cardiac Disease Diabetes >=65 Years A0BÍNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BQmRNA-1273-P301 mRNA-1273-P301-US345-2332US3452332US345USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqýlØDV‘Hr Î¼DV‘Hr Î¼DW)HréG˜DWFHsw$DWFHsw$.DW]DVvDW(DW).DVvDW(DW). Significant Cardiac Disease Diabetes >=65 Years A0BÍNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BQBQmômRNA-1273-P301 mRNA-1273-P301-US345-2332US3452332US345USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqýlØDV‘Hr Î¼DV‘Hr Î¼DW)HréG˜DWFHsw$DWFHsw$.DW]DVvDW(DW).DVvDW(DW). Significant Cardiac Disease Diabetes >=65 Years A0BÍNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BQmôBQÛèmRNA-1273-P301 mRNA-1273-P301-US345-2332US3452332US345USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWFDVvHqýlØDV‘Hr Î¼DV‘Hr Î¼DW)HréG˜DWFHsw$DWFHsw$.DW]DVvDW(DW).DVvDW(DW). Significant Cardiac Disease Diabetes >=65 Years A0BÍNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BQÛèBQIÜmRNA-1273-P301 mRNA-1273-P301-US345-2369US3452369US345USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MAMERICAN INDIAN OR ALASKA NATIVE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW2DVžHr1î@DVºHrVÉDVºHrVÉDWHrÐQ DW2HrõHôDW2HrõHô.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskAB¤Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB=mRNA-1273-P301 mRNA-1273-P301-US345-2369US3452369US345USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MAMERICAN INDIAN OR ALASKA NATIVE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW2DVžHr1î@DVºHrVÉDVºHrVÉDWHrÐQ DW2HrõHôDW2HrõHô.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskAB¤Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB=B=mômRNA-1273-P301 mRNA-1273-P301-US346-2051US3462051US346USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDWEDVuHqû£DV‘Hr óˆDV‘Hr óˆDWEHs$ðDWEHs$ð...DW]DVuDWDDWE.DVuDWDDWE. >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBimRNA-1273-P301 mRNA-1273-P301-US346-2051US3462051US346USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDWEDVuHqû£DV‘Hr óˆDV‘Hr óˆDWEHs$ðDWEHs$ð...DW]DVuDWDDWE.DVuDWDDWE. >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBiBimômRNA-1273-P301 mRNA-1273-P301-US346-2161US3462161US346USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW@DV|Hrþ0DVŸHr3‡´DVŸHr3‡´DWHrÕßÈDW@HsÀLDW@HsÀL.DW]DV|DWDW.DV|DWDW.Chronic Lung Disease Severe Obesity >=18 and <65 Years and at Risk A B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB{mRNA-1273-P301 mRNA-1273-P301-US346-2161US3462161US346USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW@DV|Hrþ0DVŸHr3‡´DVŸHr3‡´DWHrÕßÈDW@HsÀLDW@HsÀL.DW]DV|DWDW.DV|DWDW.Chronic Lung Disease Severe Obesity >=18 and <65 Years and at Risk A B¿Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB{B{mômRNA-1273-P301 mRNA-1273-P301-US346-2180US3462180US346USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW2DV}Hr\DV™Hr+:dDV™Hr+:dDWHrÍÇ4DW2HrõDW2Hrõ.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBTmRNA-1273-P301 mRNA-1273-P301-US346-2180US3462180US346USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW2DV}Hr\DV™Hr+:dDV™Hr+:dDWHrÍÇ4DW2HrõDW2Hrõ.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBTBTmômRNA-1273-P301 mRNA-1273-P301-US346-2181US3462181US346USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW2DV}HrpøDV˜Hr*%˜DV˜Hr*%˜DWHrÐH8DW2Hrõ|DW2Hrõ|.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BPmRNA-1273-P301 mRNA-1273-P301-US346-2299US3462299US346USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV¥DV‡Hr‰xDV¥Hr;[`DV¥Hr;[`.......DW]DV‡DVýDVþDVþDV‡DVýDVþDVþ >=18 and <65 Years and Not at RiskABZNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BTmRNA-1273-P301 mRNA-1273-P301-US346-2299US3462299US346USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV¥DV‡Hr‰xDV¥Hr;[`DV¥Hr;[`.......DW]DV‡DVýDVþDVþDV‡DVýDVþDVþ >=18 and <65 Years and Not at RiskABZNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BTBTmômRNA-1273-P301 mRNA-1273-P301-US346-2299US3462299US346USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV¥DV‡Hr‰xDV¥Hr;[`DV¥Hr;[`.......DW]DV‡DVýDVþDVþDV‡DVýDVþDVþ >=18 and <65 Years and Not at RiskABZNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BTmôBTÛèmRNA-1273-P301 mRNA-1273-P301-US346-2299US3462299US346USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‡DV¥DV‡Hr‰xDV¥Hr;[`DV¥Hr;[`.......DW]DV‡DVýDVþDVþDV‡DVýDVþDVþ >=18 and <65 Years and Not at RiskABZNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BTÛèBTIÜmRNA-1273-P301 mRNA-1273-P301-US346-2374US3462374US346USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWNDVŠHrà¤DV¦Hr<ÄDV¦Hr<ÄDWNHs6DWNHs6...DW]DVŠDWMDWN.DVŠDWMDWN. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B‚mRNA-1273-P301 mRNA-1273-P301-US346-2374US3462374US346USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWNDVŠHrà¤DV¦Hr<ÄDV¦Hr<ÄDWNHs6DWNHs6...DW]DVŠDWMDWN.DVŠDWMDWN. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B‚B‚mðmRNA-1273-P301 mRNA-1273-P301-US346-2374US3462374US346USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWNDVŠHrà¤DV¦Hr<ÄDV¦Hr<ÄDWNHs6DWNHs6...DW]DVŠDWMDWN.DVŠDWMDWN. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B‚mðB‚ÛèmRNA-1273-P301 mRNA-1273-P301-US346-2374US3462374US346USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWNDVŠHrà¤DV¦Hr<ÄDV¦Hr<ÄDWNHs6DWNHs6...DW]DVŠDWMDWN.DVŠDWMDWN. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B‚ÛèB‚IØmRNA-1273-P301 mRNA-1273-P301-US346-2375US3462375US346USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWNDVŠHrâDV¦Hr<ÃœDV¦Hr<ÃœDWNHs6<DWNHs6<...DW]DVŠDWMDWN.DVŠDWMDWN. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B†mRNA-1273-P301 mRNA-1273-P301-US347-2020US3472020US347USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW+DV–Hr'ˆ8DV³HrM¥@DV³HrM¥@DW+Hrëý”DW+Hrëý”...DW]DV–DW*DW+.DV–DW*DW+. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BWmRNA-1273-P301 mRNA-1273-P301-US347-2020US3472020US347USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW+DV–Hr'ˆ8DV³HrM¥@DV³HrM¥@DW+Hrëý”DW+Hrëý”...DW]DV–DW*DW+.DV–DW*DW+. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BWBWmômRNA-1273-P301 mRNA-1273-P301-US347-2020US3472020US347USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW+DV–Hr'ˆ8DV³HrM¥@DV³HrM¥@DW+Hrëý”DW+Hrëý”...DW]DV–DW*DW+.DV–DW*DW+. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BWmôBWÛèmRNA-1273-P301 mRNA-1273-P301-US347-2020US3472020US347USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW+DV–Hr'ˆ8DV³HrM¥@DV³HrM¥@DW+Hrëý”DW+Hrëý”...DW]DV–DW*DW+.DV–DW*DW+. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BWÛèBWIÜmRNA-1273-P301 mRNA-1273-P301-US347-2033US3472033US347USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV™DVµDV™Hr+{PDVµHrP‚`DVµHrP‚`.......DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BumRNA-1273-P301 mRNA-1273-P301-US347-2068US3472068US347USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DWLDV¤Hr:(XDVÀHr^üDVÀHr^üDW0Hrò TDWLHs}èDWLHs}è.DW]DV¤DW/DW0.DV¤DW/DW0. Significant Cardiac Disease Diabetes >=18 and <65 Years and at Risk A BžMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BomRNA-1273-P301 mRNA-1273-P301-US347-2068US3472068US347USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DWLDV¤Hr:(XDVÀHr^üDVÀHr^üDW0Hrò TDWLHs}èDWLHs}è.DW]DV¤DW/DW0.DV¤DW/DW0. Significant Cardiac Disease Diabetes >=18 and <65 Years and at Risk A BžMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BoBomômRNA-1273-P301 mRNA-1273-P301-US347-2068US3472068US347USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DWLDV¤Hr:(XDVÀHr^üDVÀHr^üDW0Hrò TDWLHs}èDWLHs}è.DW]DV¤DW/DW0.DV¤DW/DW0. Significant Cardiac Disease Diabetes >=18 and <65 Years and at Risk A BžMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BomôBoÛèmRNA-1273-P301 mRNA-1273-P301-US347-2099US3472099US347USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DWGDV´HrOxDVÖHr{µ\DVÖHr{µ\DW*Hrê–üDWGHs×hDWGHs×h.DW]DV´DW)DW*.DV´DW)DW*. >=18 and <65 Years and Not at RiskABˆMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BQmRNA-1273-P301 mRNA-1273-P301-US348-2036US3482036US348USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWGDV|Hr„DV˜Hr)ÿdDV˜Hr)ÿdDW)Hré4ØDWGHsàDWGHsà.DW]DV|DWDW.DV|DW(DW). >=65 Years A0BÆMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BˆmRNA-1273-P301 mRNA-1273-P301-US348-2045US3482045US348USAB:YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW0DV|HrZLDVœHr/u4DVœHr/u4DWHrÍ’xDW0Hròo”DW0Hròo”.DW]DV|DWDW.DV|DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BgmRNA-1273-P301 mRNA-1273-P301-US348-2045US3482045US348USAB:YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW0DV|HrZLDVœHr/u4DVœHr/u4DWHrÍ’xDW0Hròo”DW0Hròo”.DW]DV|DWDW.DV|DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BgBgmômRNA-1273-P301 mRNA-1273-P301-US348-2045US3482045US348USAB:YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW0DV|HrZLDVœHr/u4DVœHr/u4DWHrÍ’xDW0Hròo”DW0Hròo”.DW]DV|DWDW.DV|DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BgmôBgÛèmRNA-1273-P301 mRNA-1273-P301-US348-2045US3482045US348USAB:YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DW0DV|HrZLDVœHr/u4DVœHr/u4DWHrÍ’xDW0Hròo”DW0Hròo”.DW]DV|DWDW.DV|DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BgÛèBgIÜmRNA-1273-P301 mRNA-1273-P301-US348-2049US3482049US348USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV}DV˜DV}Hr\ÐDV˜Hr* xDV˜Hr* x.......DW]DV}DWDW.DV}DWDW. >=65 Years A0BÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB™mRNA-1273-P301 mRNA-1273-P301-US348-2049US3482049US348USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV}DV˜DV}Hr\ÐDV˜Hr* xDV˜Hr* x.......DW]DV}DWDW.DV}DWDW. >=65 Years A0BÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB™B™mðmRNA-1273-P301 mRNA-1273-P301-US348-2094US3482094US348USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDV¤DVƒHrCxDV¤Hr9ÃTDV¤Hr9ÃT.......DW]DVƒDWDW.DVƒDWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BwmRNA-1273-P301 mRNA-1273-P301-US348-2094US3482094US348USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDV¤DVƒHrCxDV¤Hr9ÃTDV¤Hr9ÃT.......DW]DVƒDWDW.DVƒDWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BwBwmômRNA-1273-P301 mRNA-1273-P301-US348-2094US3482094US348USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDV¤DVƒHrCxDV¤Hr9ÃTDV¤Hr9ÃT.......DW]DVƒDWDW.DVƒDWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BwmôBwÛèmRNA-1273-P301 mRNA-1273-P301-US348-2094US3482094US348USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDV¤DVƒHrCxDV¤Hr9ÃTDV¤Hr9ÃT.......DW]DVƒDWDW.DVƒDWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BwÛèBwIÜmRNA-1273-P301 mRNA-1273-P301-US348-2121US3482121US348USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW,DV‡Hr¿$DV£Hr8’àDV£Hr8’àDWHrÈ/hDW,Hrí%ÔDW,Hrí%Ô.DW]DV‡DWDW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BTmRNA-1273-P301 mRNA-1273-P301-US348-2121US3482121US348USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW,DV‡Hr¿$DV£Hr8’àDV£Hr8’àDWHrÈ/hDW,Hrí%ÔDW,Hrí%Ô.DW]DV‡DWDW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BTBTmômRNA-1273-P301 mRNA-1273-P301-US348-2121US3482121US348USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW,DV‡Hr¿$DV£Hr8’àDV£Hr8’àDWHrÈ/hDW,Hrí%ÔDW,Hrí%Ô.DW]DV‡DWDW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BTmôBTÛèmRNA-1273-P301 mRNA-1273-P301-US348-2187US3482187US348USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWGDVHrGdDV«HrC˜DV«HrC˜DW(Hrçî\DWGHsÃDWGHsÃ.DW]DVDW DW.DVDW'DW(. >=18 and <65 Years and Not at RiskAB³Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B~mRNA-1273-P301 mRNA-1273-P301-US348-2187US3482187US348USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWGDVHrGdDV«HrC˜DV«HrC˜DW(Hrçî\DWGHsÃDWGHsÃ.DW]DVDW DW.DVDW'DW(. >=18 and <65 Years and Not at RiskAB³Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B~B~mômRNA-1273-P301 mRNA-1273-P301-US348-2187US3482187US348USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWGDVHrGdDV«HrC˜DV«HrC˜DW(Hrçî\DWGHsÃDWGHsÃ.DW]DVDW DW.DVDW'DW(. >=18 and <65 Years and Not at RiskAB³Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B~môB~ÛèmRNA-1273-P301 mRNA-1273-P301-US348-2304US3482304US348USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV¿DVÛDV¿Hr]†|DVÛHr‚c\DVÛHr‚c\.......DW]DV¿DWDW.DV¿DWDW. >=18 and <65 Years and Not at RiskABƒMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAANo symptom BžmRNA-1273-P301 mRNA-1273-P301-US349-2071US3492071US349USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW3DV’Hr"[LDV±HrK¼DV±HrK¼DWHrÑ~ÄDW3Hrö^ìDW3Hrö^ì.DW]DV’DWDW.DV’DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BImRNA-1273-P301 mRNA-1273-P301-US349-2071US3492071US349USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW3DV’Hr"[LDV±HrK¼DV±HrK¼DWHrÑ~ÄDW3Hrö^ìDW3Hrö^ì.DW]DV’DWDW.DV’DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BIBImômRNA-1273-P301 mRNA-1273-P301-US349-2071US3492071US349USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW3DV’Hr"[LDV±HrK¼DV±HrK¼DWHrÑ~ÄDW3Hrö^ìDW3Hrö^ì.DW]DV’DWDW.DV’DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BImôBIÛèmRNA-1273-P301 mRNA-1273-P301-US349-2071US3492071US349USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW3DV’Hr"[LDV±HrK¼DV±HrK¼DWHrÑ~ÄDW3Hrö^ìDW3Hrö^ì.DW]DV’DWDW.DV’DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BIÛèBIIÜmRNA-1273-P301 mRNA-1273-P301-US349-2142US3492142US349USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWODVšHr,õÔDVÀHr_°DVÀHr_°DW*Hrê„´DWOHs|¸DWOHs|¸.DW]DVšDW)DW*.DVšDW)DW*. >=18 and <65 Years and Not at RiskABžMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBQmRNA-1273-P301 mRNA-1273-P301-US349-2142US3492142US349USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWODVšHr,õÔDVÀHr_°DVÀHr_°DW*Hrê„´DWOHs|¸DWOHs|¸.DW]DVšDW)DW*.DVšDW)DW*. >=18 and <65 Years and Not at RiskABžMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBQBQmômRNA-1273-P301 mRNA-1273-P301-US350-2076US3502076US350USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MAMERICAN INDIAN OR ALASKA NATIVE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW/DVHrZœDV«HrC:LDV«HrC:LDWHrÌclDW/Hrñ#´DW/Hrñ#´.DW]DVDWDW.DVDWDW. >=65 Years A0B³Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBTmRNA-1273-P301 mRNA-1273-P301-US350-2076US3502076US350USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MAMERICAN INDIAN OR ALASKA NATIVE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW/DVHrZœDV«HrC:LDV«HrC:LDWHrÌclDW/Hrñ#´DW/Hrñ#´.DW]DVDWDW.DVDWDW. >=65 Years A0B³Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBTBTmômRNA-1273-P301 mRNA-1273-P301-US350-2086US3502086US350USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW>DVHrÂØDVªHrAödDVªHrAödDW!HrÞÓDDW>HsüDW>Hsü.DW]DVDW DW!.DVDW DW!. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BYmRNA-1273-P301 mRNA-1273-P301-US351-2116US3512116US351USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW,DV„Hr‹ DV Hr4iàDV Hr4iàDWHrÈNXDW,HríOPDW,HríOP.DW]DV„DWDW.DV„DWDW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BTmRNA-1273-P301 mRNA-1273-P301-US351-2116US3512116US351USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW,DV„Hr‹ DV Hr4iàDV Hr4iàDWHrÈNXDW,HríOPDW,HríOP.DW]DV„DWDW.DV„DWDW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BTBTmômRNA-1273-P301 mRNA-1273-P301-US351-2116US3512116US351USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW,DV„Hr‹ DV Hr4iàDV Hr4iàDWHrÈNXDW,HríOPDW,HríOP.DW]DV„DWDW.DV„DWDW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BTmôBTÛèmRNA-1273-P301 mRNA-1273-P301-US351-2242US3512242US351USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DWMDV—Hr(óDV³HrM½ DV³HrM½ DW1Hró²ŒDWMHs–tDWMHs–t.DW]DV—DW0DW1.DV—DW0DW1. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B|mRNA-1273-P301 mRNA-1273-P301-US351-2242US3512242US351USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DWMDV—Hr(óDV³HrM½ DV³HrM½ DW1Hró²ŒDWMHs–tDWMHs–t.DW]DV—DW0DW1.DV—DW0DW1. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B|B|mômRNA-1273-P301 mRNA-1273-P301-US351-2242US3512242US351USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DWMDV—Hr(óDV³HrM½ DV³HrM½ DW1Hró²ŒDWMHs–tDWMHs–t.DW]DV—DW0DW1.DV—DW0DW1. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B|môB|ÛèmRNA-1273-P301 mRNA-1273-P301-US351-2263US3512263US351USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWHDVšHr,·@DVºHrWLDVºHrWLDWHHsø DWHHsø ...DW]DVšDWGDWH.DVšDWGDWH. >=18 and <65 Years and Not at RiskAB¤Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BEmRNA-1273-P301 mRNA-1273-P301-US351-2263US3512263US351USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWHDVšHr,·@DVºHrWLDVºHrWLDWHHsø DWHHsø ...DW]DVšDWGDWH.DVšDWGDWH. >=18 and <65 Years and Not at RiskAB¤Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BEBEmômRNA-1273-P301 mRNA-1273-P301-US351-2263US3512263US351USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWHDVšHr,·@DVºHrWLDVºHrWLDWHHsø DWHHsø ...DW]DVšDWGDWH.DVšDWGDWH. >=18 and <65 Years and Not at RiskAB¤Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BEmôBEÛèmRNA-1273-P301 mRNA-1273-P301-US351-2263US3512263US351USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVšDWHDVšHr,·@DVºHrWLDVºHrWLDWHHsø DWHHsø ...DW]DVšDWGDWH.DVšDWGDWH. >=18 and <65 Years and Not at RiskAB¤Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BEÛèBEIÜmRNA-1273-P301 mRNA-1273-P301-US352-2105US3522105US352USAB%YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV{DV–DV{Hr |DV–Hr'n¬DV–Hr'n¬.......DW]DV{DWDWDWDV{DWDWDW >=18 and <65 Years and Not at RiskABqNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BKmRNA-1273-P301 mRNA-1273-P301-US352-2127US3522127US352USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW/DV}HrLhDV™Hr+:(DV™Hr+:(DWHrÈDW/HrðùÀDW/HrðùÀ.DW]DV}DWDW.DV}DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BzmRNA-1273-P301 mRNA-1273-P301-US352-2218US3522218US352USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW8DV‚Hr 4DVžHr1ôXDVžHr1ôXDWHrÖÉtDW8Hrüù<DW8Hrüù<.DW]DV‚DWDW.DV‚DWDW. Significant Cardiac Disease Diabetes >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BZmRNA-1273-P301 mRNA-1273-P301-US352-2218US3522218US352USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW8DV‚Hr 4DVžHr1ôXDVžHr1ôXDWHrÖÉtDW8Hrüù<DW8Hrüù<.DW]DV‚DWDW.DV‚DWDW. Significant Cardiac Disease Diabetes >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BZBZmômRNA-1273-P301 mRNA-1273-P301-US352-2218US3522218US352USAB;YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW8DV‚Hr 4DVžHr1ôXDVžHr1ôXDWHrÖÉtDW8Hrüù<DW8Hrüù<.DW]DV‚DWDW.DV‚DWDW. Significant Cardiac Disease Diabetes >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BZmôBZÛèmRNA-1273-P301 mRNA-1273-P301-US352-2248US3522248US352USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW?DVƒHr]ôDVžHr1ï0DVžHr1ï0DW#Hrá<ØDW?HsDW?Hs.DW]DVƒDW"DW#.DVƒDW"DW#. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B„mRNA-1273-P301 mRNA-1273-P301-US352-2460US3522460US352USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWGDVŽHràÌDV±HrKlDV±HrKlDW#HráB<DWGHsÖDWGHsÖ.DW]DVŽDW"DW#.DVŽDW"DW#. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BxmRNA-1273-P301 mRNA-1273-P301-US352-2460US3522460US352USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWGDVŽHràÌDV±HrKlDV±HrKlDW#HráB<DWGHsÖDWGHsÖ.DW]DVŽDW"DW#.DVŽDW"DW#. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BxBxmômRNA-1273-P301 mRNA-1273-P301-US352-2460US3522460US352USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWGDVŽHràÌDV±HrKlDV±HrKlDW#HráB<DWGHsÖDWGHsÖ.DW]DVŽDW"DW#.DVŽDW"DW#. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BxmôBxÛèmRNA-1273-P301 mRNA-1273-P301-US352-2672US3522672US352USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV™DVºDV™Hr+‰œDVºHrVÿdDVºHrVÿd......DWDWDV™DWDWDWDV™DWDWDW >=18 and <65 Years and Not at RiskABWNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB_mRNA-1273-P301 mRNA-1273-P301-US352-2672US3522672US352USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV™DVºDV™Hr+‰œDVºHrVÿdDVºHrVÿd......DWDWDV™DWDWDWDV™DWDWDW >=18 and <65 Years and Not at RiskABWNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB_B_mômRNA-1273-P301 mRNA-1273-P301-US353-2103US3532103US353USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW0DV„Hr£¼DV¥Hr;#˜DV¥Hr;#˜DWHrÌMdDW0HròYÈDW0HròYÈ.DW]DV„DWDW.DV„DWDW. Diabetes >=65 Years A0B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BbmRNA-1273-P301 mRNA-1273-P301-US353-2103US3532103US353USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW0DV„Hr£¼DV¥Hr;#˜DV¥Hr;#˜DWHrÌMdDW0HròYÈDW0HròYÈ.DW]DV„DWDW.DV„DWDW. Diabetes >=65 Years A0B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BbBbmômRNA-1273-P301 mRNA-1273-P301-US353-2103US3532103US353USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW0DV„Hr£¼DV¥Hr;#˜DV¥Hr;#˜DWHrÌMdDW0HròYÈDW0HròYÈ.DW]DV„DWDW.DV„DWDW. Diabetes >=65 Years A0B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BbmôBbÛèmRNA-1273-P301 mRNA-1273-P301-US353-2103US3532103US353USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW0DV„Hr£¼DV¥Hr;#˜DV¥Hr;#˜DWHrÌMdDW0HròYÈDW0HròYÈ.DW]DV„DWDW.DV„DWDW. Diabetes >=65 Years A0B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BbÛèBbIÜmRNA-1273-P301 mRNA-1273-P301-US353-2163US3532163US353USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW9DV‰Hr‘@DV¤Hr:#¨DV¤Hr:#¨DWHrÚ”xDW9Hrþ0|DW9Hrþ0|.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBDmRNA-1273-P301 mRNA-1273-P301-US353-2163US3532163US353USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW9DV‰Hr‘@DV¤Hr:#¨DV¤Hr:#¨DWHrÚ”xDW9Hrþ0|DW9Hrþ0|.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBDBDmômRNA-1273-P301 mRNA-1273-P301-US353-2165US3532165US353USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW+DVŠHroèDV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BCmRNA-1273-P301 mRNA-1273-P301-US353-2165US3532165US353USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW+DVŠHroèDV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BCBCmômRNA-1273-P301 mRNA-1273-P301-US353-2165US3532165US353USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW+DVŠHroèDV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BCmôBCÛèmRNA-1273-P301 mRNA-1273-P301-US353-2165US3532165US353USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW+DVŠHroèDV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BCÛèBCIÜmRNA-1273-P301 mRNA-1273-P301-US353-2246US3532246US353USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW1DV–Hr'B`DV²HrL$hDV²HrL$hDWHrÈxDW1Hró¦\DW1Hró¦\.DW]DV–DWDW.DV–DWDW. >=65 Years A0B¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B2mRNA-1273-P301 mRNA-1273-P301-US353-2246US3532246US353USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW1DV–Hr'B`DV²HrL$hDV²HrL$hDWHrÈxDW1Hró¦\DW1Hró¦\.DW]DV–DWDW.DV–DWDW. >=65 Years A0B¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B2B2mômRNA-1273-P301 mRNA-1273-P301-US353-2246US3532246US353USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW1DV–Hr'B`DV²HrL$hDV²HrL$hDWHrÈxDW1Hró¦\DW1Hró¦\.DW]DV–DWDW.DV–DWDW. >=65 Years A0B¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B2môB2ÛæmRNA-1273-P301 mRNA-1273-P301-US353-2251US3532251US353USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW*DV–Hr'ØDV²HrLVÌDV²HrLVÌDWHrÇäDW*HrêªèDW*Hrêªè.DW]DV–DWDW.DV–DWDW. Significant Cardiac Disease >=65 Years A0B¬Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BUmRNA-1273-P301 mRNA-1273-P301-US353-2251US3532251US353USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW*DV–Hr'ØDV²HrLVÌDV²HrLVÌDWHrÇäDW*HrêªèDW*Hrêªè.DW]DV–DWDW.DV–DWDW. Significant Cardiac Disease >=65 Years A0B¬Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BUBUmômRNA-1273-P301 mRNA-1273-P301-US353-2251US3532251US353USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW*DV–Hr'ØDV²HrLVÌDV²HrLVÌDWHrÇäDW*HrêªèDW*Hrêªè.DW]DV–DWDW.DV–DWDW. Significant Cardiac Disease >=65 Years A0B¬Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BUmôBUÛèmRNA-1273-P301 mRNA-1273-P301-US353-2259US3532259US353USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV—DV³DV—Hr(‘DV³HrMåðDV³HrMåð.......DW]DV—DW1DW2.DV—DW1DW2. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B2mRNA-1273-P301 mRNA-1273-P301-US354-2019US3542019US354USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWUDVHrõÈDVHr0ª”DVHr0ª”DW8HrüòèDWUHs#@ìDWUHs#@ì.DW]DVDWDW.DVDW7DW8. >=65 Years A0BÁMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmRNA-1273-P301 mRNA-1273-P301-US354-2019US3542019US354USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWUDVHrõÈDVHr0ª”DVHr0ª”DW8HrüòèDWUHs#@ìDWUHs#@ì.DW]DVDWDW.DVDW7DW8. >=65 Years A0BÁMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBmðmRNA-1273-P301 mRNA-1273-P301-US354-2153US3542153US354USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW2DV’Hr"DVµHrP˜DVµHrP˜DWHrÑaDW2Hrõ/hDW2Hrõ/h.DW]DV’DWDW.DV’DWDW. >=18 and <65 Years and Not at RiskAB©Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BImRNA-1273-P301 mRNA-1273-P301-US354-2153US3542153US354USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW2DV’Hr"DVµHrP˜DVµHrP˜DWHrÑaDW2Hrõ/hDW2Hrõ/h.DW]DV’DWDW.DV’DWDW. >=18 and <65 Years and Not at RiskAB©Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BIBImômRNA-1273-P301 mRNA-1273-P301-US354-2153US3542153US354USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW2DV’Hr"DVµHrP˜DVµHrP˜DWHrÑaDW2Hrõ/hDW2Hrõ/h.DW]DV’DWDW.DV’DWDW. >=18 and <65 Years and Not at RiskAB©Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BImôBIÛèmRNA-1273-P301 mRNA-1273-P301-US354-2339US3542339US354USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DWKDV¹HrU½˜DVØHr~¹dDVØHr~¹dDW2Hrõ,\DWKHsÛŒDWKHsÛŒ.DW]DV¹DW1DW2.DV¹DW1DW2. >=18 and <65 Years and Not at RiskAB†Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BbmRNA-1273-P301 mRNA-1273-P301-US354-2339US3542339US354USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DWKDV¹HrU½˜DVØHr~¹dDVØHr~¹dDW2Hrõ,\DWKHsÛŒDWKHsÛŒ.DW]DV¹DW1DW2.DV¹DW1DW2. >=18 and <65 Years and Not at RiskAB†Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BbBbmômRNA-1273-P301 mRNA-1273-P301-US354-2339US3542339US354USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DWKDV¹HrU½˜DVØHr~¹dDVØHr~¹dDW2Hrõ,\DWKHsÛŒDWKHsÛŒ.DW]DV¹DW1DW2.DV¹DW1DW2. >=18 and <65 Years and Not at RiskAB†Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BbmôBbÛèmRNA-1273-P301 mRNA-1273-P301-US355-2002US3552002US355USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW/DVyHriPDV•Hr&3èDV•Hr&3èDWHrÍ¼¨DW/HrñS„DW/HrñS„.DW]DVyDVøDVù.DVyDWDW. >=18 and <65 Years and Not at RiskABÉNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B*mRNA-1273-P301 mRNA-1273-P301-US355-2002US3552002US355USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW/DVyHriPDV•Hr&3èDV•Hr&3èDWHrÍ¼¨DW/HrñS„DW/HrñS„.DW]DVyDVøDVù.DVyDWDW. >=18 and <65 Years and Not at RiskABÉNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B*B*mômRNA-1273-P301 mRNA-1273-P301-US355-2002US3552002US355USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW/DVyHriPDV•Hr&3èDV•Hr&3èDWHrÍ¼¨DW/HrñS„DW/HrñS„.DW]DVyDVøDVù.DVyDWDW. >=18 and <65 Years and Not at RiskABÉNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B*môB*ÛæmRNA-1273-P301 mRNA-1273-P301-US355-2020US3552020US355USABLYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW:DV{Hr|DV—Hr(ÈDV—Hr(ÈDW!HrÞ}¸DW:Hrÿz@DW:Hrÿz@.DW]DV{DW DW!.DV{DW DW!. >=65 Years A0BÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BxmRNA-1273-P301 mRNA-1273-P301-US355-2023US3552023US355USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWEDV|Hr)PDV—Hr(´°DV—Hr(´°DW)Hré¨DWEHs ÿ4DWEHs ÿ4.DW]DV|DWDW.DV|DW(DW). Severe Obesity Liver Disease >=18 and <65 Years and at Risk A BÇNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BgmRNA-1273-P301 mRNA-1273-P301-US355-2023US3552023US355USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWEDV|Hr)PDV—Hr(´°DV—Hr(´°DW)Hré¨DWEHs ÿ4DWEHs ÿ4.DW]DV|DWDW.DV|DW(DW). Severe Obesity Liver Disease >=18 and <65 Years and at Risk A BÇNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BgBgmômRNA-1273-P301 mRNA-1273-P301-US355-2023US3552023US355USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWEDV|Hr)PDV—Hr(´°DV—Hr(´°DW)Hré¨DWEHs ÿ4DWEHs ÿ4.DW]DV|DWDW.DV|DW(DW). Severe Obesity Liver Disease >=18 and <65 Years and at Risk A BÇNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BgmôBgÛèmRNA-1273-P301 mRNA-1273-P301-US355-2048US3552048US355USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW0DV€Hr FˆDV™Hr+0ŒDV™Hr+0ŒDWHrÎé\DW0Hrò’€DW0Hrò’€.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B\mRNA-1273-P301 mRNA-1273-P301-US355-2048US3552048US355USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW0DV€Hr FˆDV™Hr+0ŒDV™Hr+0ŒDWHrÎé\DW0Hrò’€DW0Hrò’€.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B\B\mômRNA-1273-P301 mRNA-1273-P301-US355-2048US3552048US355USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW0DV€Hr FˆDV™Hr+0ŒDV™Hr+0ŒDWHrÎé\DW0Hrò’€DW0Hrò’€.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B\môB\ÛèmRNA-1273-P301 mRNA-1273-P301-US355-2153US3552153US355USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWKDV‡HrÛøDV£Hr8«DV£Hr8«DW)Hrén¼DWKHsãÀDWKHsãÀ.DW]DV‡DW(DW).DV‡DW(DW). >=18 and <65 Years and Not at RiskAB»Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BxmRNA-1273-P301 mRNA-1273-P301-US355-2153US3552153US355USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWKDV‡HrÛøDV£Hr8«DV£Hr8«DW)Hrén¼DWKHsãÀDWKHsãÀ.DW]DV‡DW(DW).DV‡DW(DW). >=18 and <65 Years and Not at RiskAB»Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BxBxmômRNA-1273-P301 mRNA-1273-P301-US355-2153US3552153US355USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWKDV‡HrÛøDV£Hr8«DV£Hr8«DW)Hrén¼DWKHsãÀDWKHsãÀ.DW]DV‡DW(DW).DV‡DW(DW). >=18 and <65 Years and Not at RiskAB»Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BxmôBxÛèmRNA-1273-P301 mRNA-1273-P301-US355-2153US3552153US355USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWKDV‡HrÛøDV£Hr8«DV£Hr8«DW)Hrén¼DWKHsãÀDWKHsãÀ.DW]DV‡DW(DW).DV‡DW(DW). >=18 and <65 Years and Not at RiskAB»Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BxÛèBxIÜmRNA-1273-P301 mRNA-1273-P301-US355-2269US3552269US355USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW>DVHr9DV«HrC$øDV«HrC$øDW"HràxDW>HsùèDW>Hsùè.DW]DVDW!DW".DVDW!DW". >=65 Years A0B³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBHmRNA-1273-P301 mRNA-1273-P301-US355-2269US3552269US355USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW>DVHr9DV«HrC$øDV«HrC$øDW"HràxDW>HsùèDW>Hsùè.DW]DVDW!DW".DVDW!DW". >=65 Years A0B³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBHBHmômRNA-1273-P301 mRNA-1273-P301-US355-2270US3552270US355USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWEDVHr7ìDV«HrCÌDV«HrCÌDW)Hré-DWEHs(DWEHs(.DW]DVDW(DW).DVDW(DW). >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBhmRNA-1273-P301 mRNA-1273-P301-US355-2270US3552270US355USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWEDVHr7ìDV«HrCÌDV«HrCÌDW)Hré-DWEHs(DWEHs(.DW]DVDW(DW).DVDW(DW). >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBhBhmômRNA-1273-P301 mRNA-1273-P301-US355-2325US3552325US355USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW:DV’Hr"DV®HrG%¨DV®HrG%¨DWHrÍ½ÔDW:HrÿÕ0DW:HrÿÕ0.DW]DV’DWDW.DV’DWDW. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB[mRNA-1273-P301 mRNA-1273-P301-US355-2325US3552325US355USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DW:DV’Hr"DV®HrG%¨DV®HrG%¨DWHrÍ½ÔDW:HrÿÕ0DW:HrÿÕ0.DW]DV’DWDW.DV’DWDW. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB[B[mômRNA-1273-P301 mRNA-1273-P301-US356-2015US3562015US356USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVuDV‘DVuHqü'ÄDV‘Hr!8DV‘Hr!8.......DW]DVuDW5DW6DWZDVuDW5DW6DWZ Diabetes >=18 and <65 Years and at Risk A BÊMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B”mRNA-1273-P301 mRNA-1273-P301-US356-2015US3562015US356USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVuDV‘DVuHqü'ÄDV‘Hr!8DV‘Hr!8.......DW]DVuDW5DW6DWZDVuDW5DW6DWZ Diabetes >=18 and <65 Years and at Risk A BÊMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B”B”mðmRNA-1273-P301 mRNA-1273-P301-US356-2015US3562015US356USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVuDV‘DVuHqü'ÄDV‘Hr!8DV‘Hr!8.......DW]DVuDW5DW6DWZDVuDW5DW6DWZ Diabetes >=18 and <65 Years and at Risk A BÊMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B”mðB”ÛèmRNA-1273-P301 mRNA-1273-P301-US356-2015US3562015US356USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVuDV‘DVuHqü'ÄDV‘Hr!8DV‘Hr!8.......DW]DVuDW5DW6DWZDVuDW5DW6DWZ Diabetes >=18 and <65 Years and at Risk A BÊMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B”ÛèB”IØmRNA-1273-P301 mRNA-1273-P301-US356-2040US3562040US356USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV DV}Hr}dDV Hr4€DV Hr4€......DVôDVôDV}DW..DV}DW.. >=18 and <65 Years and Not at RiskABmMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BnmRNA-1273-P301 mRNA-1273-P301-US356-2040US3562040US356USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV DV}Hr}dDV Hr4€DV Hr4€......DVôDVôDV}DW..DV}DW.. >=18 and <65 Years and Not at RiskABmMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BnBnmômRNA-1273-P301 mRNA-1273-P301-US356-2040US3562040US356USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV DV}Hr}dDV Hr4€DV Hr4€......DVôDVôDV}DW..DV}DW.. >=18 and <65 Years and Not at RiskABmMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BnmôBnÛèmRNA-1273-P301 mRNA-1273-P301-US356-2073US3562073US356USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWYDV‡HrÛDDV£Hr8«|DV£Hr8«|DW=Hs´\DWYHs(‘´DWYHs(‘´.DW]DV‡DW<DW=.DV‡DW<DW=. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB“mRNA-1273-P301 mRNA-1273-P301-US356-2073US3562073US356USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWYDV‡HrÛDDV£Hr8«|DV£Hr8«|DW=Hs´\DWYHs(‘´DWYHs(‘´.DW]DV‡DW<DW=.DV‡DW<DW=. >=18 and <65 Years and Not at RiskAB»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB“B“mðmRNA-1273-P301 mRNA-1273-P301-US356-2076US3562076US356USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW@DVˆHrLDV¤Hr9êDV¤Hr9êDW$HrâÈ´DW@Hs…´DW@Hs…´.DW]DVˆDW#DW$.DVˆDW#DW$. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BsmRNA-1273-P301 mRNA-1273-P301-US356-2144US3562144US356USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWDDV˜Hr*ÐDVµHrP:äDVµHrP:äDW(HrçÖ8DWDHsÄèDWDHsÄè.DW]DV˜DW'DW(.DV˜DW'DW(. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BSmRNA-1273-P301 mRNA-1273-P301-US356-2144US3562144US356USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWDDV˜Hr*ÐDVµHrP:äDVµHrP:äDW(HrçÖ8DWDHsÄèDWDHsÄè.DW]DV˜DW'DW(.DV˜DW'DW(. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BSBSmômRNA-1273-P301 mRNA-1273-P301-US356-2144US3562144US356USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWDDV˜Hr*ÐDVµHrP:äDVµHrP:äDW(HrçÖ8DWDHsÄèDWDHsÄè.DW]DV˜DW'DW(.DV˜DW'DW(. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BSmôBSÛèmRNA-1273-P301 mRNA-1273-P301-US356-2218US3562218US356USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DW=DV³HrMu4DVÏHrr^¼DVÏHrr^¼DW"HrßÎÀDW=Hs_üDW=Hs_ü.DW]DV³DW!DW".DV³DW!DW". >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B1mRNA-1273-P301 mRNA-1273-P301-US356-2218US3562218US356USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DW=DV³HrMu4DVÏHrr^¼DVÏHrr^¼DW"HrßÎÀDW=Hs_üDW=Hs_ü.DW]DV³DW!DW".DV³DW!DW". >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B1B1mômRNA-1273-P301 mRNA-1273-P301-US356-2218US3562218US356USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DW=DV³HrMu4DVÏHrr^¼DVÏHrr^¼DW"HrßÎÀDW=Hs_üDW=Hs_ü.DW]DV³DW!DW".DV³DW!DW". >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B1môB1ÛæmRNA-1273-P301 mRNA-1273-P301-US356-2220US3562220US356USAB-YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV´DVÐDV´HrNÕðDVÐHrsÊ|DVÐHrsÊ|.......DW]DV´DW%..DV´DW%.. Diabetes >=18 and <65 Years and at Risk A BVMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BYmRNA-1273-P301 mRNA-1273-P301-US356-2220US3562220US356USAB-YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV´DVÐDV´HrNÕðDVÐHrsÊ|DVÐHrsÊ|.......DW]DV´DW%..DV´DW%.. Diabetes >=18 and <65 Years and at Risk A BVMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BYBYmômRNA-1273-P301 mRNA-1273-P301-US356-2220US3562220US356USAB-YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV´DVÐDV´HrNÕðDVÐHrsÊ|DVÐHrsÊ|.......DW]DV´DW%..DV´DW%.. Diabetes >=18 and <65 Years and at Risk A BVMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BYmôBYÛèmRNA-1273-P301 mRNA-1273-P301-US357-2004US3572004US357USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV€DVœDV€Hr fhDVœHr/(DVœHr/(......DWODWODV€DW!DW"DWODV€DW!DW"DWO >=65 Years A0B´Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BwmRNA-1273-P301 mRNA-1273-P301-US357-2004US3572004US357USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV€DVœDV€Hr fhDVœHr/(DVœHr/(......DWODWODV€DW!DW"DWODV€DW!DW"DWO >=65 Years A0B´Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BwBwmômRNA-1273-P301 mRNA-1273-P301-US357-2004US3572004US357USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV€DVœDV€Hr fhDVœHr/(DVœHr/(......DWODWODV€DW!DW"DWODV€DW!DW"DWO >=65 Years A0B´Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BwmôBwÛèmRNA-1273-P301 mRNA-1273-P301-US357-2004US3572004US357USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV€DVœDV€Hr fhDVœHr/(DVœHr/(......DWODWODV€DW!DW"DWODV€DW!DW"DWO >=65 Years A0B´Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BwÛèBwIÜmRNA-1273-P301 mRNA-1273-P301-US357-2030US3572030US357USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV‚DV£DV‚Hr $\DV£Hr8šØDV£Hr8šØ.......DW]DV‚DWDW.DV‚DWDW. >=18 and <65 Years and Not at RiskAB»Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BwmRNA-1273-P301 mRNA-1273-P301-US357-2036US3572036US357USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW@DVƒHrO¨DV¥Hr;4DV¥Hr;4DW@HsèœDW@Hsèœ...DW]DVƒDW DW!.DVƒDW?DW@. >=18 and <65 Years and Not at RiskAB¹Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‹mRNA-1273-P301 mRNA-1273-P301-US357-2156US3572156US357USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW]DVHrXDV¬HrD„ÄDV¬HrD„ÄDW@HsãìDW]Hs-ñ¸DW]Hs-ñ¸.DW]DVDW DW!.DVDW?DW@. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BemRNA-1273-P301 mRNA-1273-P301-US357-2156US3572156US357USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW]DVHrXDV¬HrD„ÄDV¬HrD„ÄDW@HsãìDW]Hs-ñ¸DW]Hs-ñ¸.DW]DVDW DW!.DVDW?DW@. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BeBemômRNA-1273-P301 mRNA-1273-P301-US357-2156US3572156US357USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW]DVHrXDV¬HrD„ÄDV¬HrD„ÄDW@HsãìDW]Hs-ñ¸DW]Hs-ñ¸.DW]DVDW DW!.DVDW?DW@. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BemôBeÛèmRNA-1273-P301 mRNA-1273-P301-US357-2174US3572174US357USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW8DV‘Hr °€DV®HrFÞhDV®HrFÞhDWHrÕÆxDW8HrýE¤DW8HrýE¤.DW]DV‘DWDW.DV‘DWDW. Diabetes >=18 and <65 Years and at Risk A B°Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BmmRNA-1273-P301 mRNA-1273-P301-US357-2174US3572174US357USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW8DV‘Hr °€DV®HrFÞhDV®HrFÞhDWHrÕÆxDW8HrýE¤DW8HrýE¤.DW]DV‘DWDW.DV‘DWDW. Diabetes >=18 and <65 Years and at Risk A B°Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BmBmmômRNA-1273-P301 mRNA-1273-P301-US357-2174US3572174US357USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW8DV‘Hr °€DV®HrFÞhDV®HrFÞhDWHrÕÆxDW8HrýE¤DW8HrýE¤.DW]DV‘DWDW.DV‘DWDW. Diabetes >=18 and <65 Years and at Risk A B°Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BmmôBmÛèmRNA-1273-P301 mRNA-1273-P301-US357-2174US3572174US357USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW8DV‘Hr °€DV®HrFÞhDV®HrFÞhDWHrÕÆxDW8HrýE¤DW8HrýE¤.DW]DV‘DWDW.DV‘DWDW. Diabetes >=18 and <65 Years and at Risk A B°Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BmÛèBmIÜmRNA-1273-P301 mRNA-1273-P301-US357-2186US3572186US357USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV’DV±DV’Hr"äDV±HrJæ˜DV±HrJæ˜......DWRDWRDV’DWU..DV’DWU.. Severe Obesity >=18 and <65 Years and at Risk A B¥Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBMmRNA-1273-P301 mRNA-1273-P301-US357-2186US3572186US357USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV’DV±DV’Hr"äDV±HrJæ˜DV±HrJæ˜......DWRDWRDV’DWU..DV’DWU.. Severe Obesity >=18 and <65 Years and at Risk A B¥Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBMBMmômRNA-1273-P301 mRNA-1273-P301-US357-2256US3572256US357USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWNDV˜Hr*$lDV³HrM¶ DV³HrM¶ DWNHs3äDWNHs3ä...DW]DV˜DW.DW/.DV˜DWMDWN. Severe Obesity >=18 and <65 Years and at Risk A B«Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BvmRNA-1273-P301 mRNA-1273-P301-US357-2306US3572306US357USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW[DVžHr1óhDV¸HrT \DV¸HrT \DW2HrõiˆDW[Hs+CðDW[Hs+Cð.DW]DVžDW.DW/.DVžDW1DW2. >=18 and <65 Years and Not at RiskAB¦Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BnmRNA-1273-P301 mRNA-1273-P301-US357-2320US3572320US357USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DW?DV£Hr8®ÄDVÃHrb–ÐDVÃHrb–ÐDW#HráÂpDW?Hs¥,DW?Hs¥,.DW]DV£DW!DW".DV£DW"DW#. Diabetes >=18 and <65 Years and at Risk A B›Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B]mRNA-1273-P301 mRNA-1273-P301-US357-2320US3572320US357USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DW?DV£Hr8®ÄDVÃHrb–ÐDVÃHrb–ÐDW#HráÂpDW?Hs¥,DW?Hs¥,.DW]DV£DW!DW".DV£DW"DW#. Diabetes >=18 and <65 Years and at Risk A B›Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B]B]mômRNA-1273-P301 mRNA-1273-P301-US357-2320US3572320US357USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DW?DV£Hr8®ÄDVÃHrb–ÐDVÃHrb–ÐDW#HráÂpDW?Hs¥,DW?Hs¥,.DW]DV£DW!DW".DV£DW"DW#. Diabetes >=18 and <65 Years and at Risk A B›Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B]môB]ÛèmRNA-1273-P301 mRNA-1273-P301-US357-2320US3572320US357USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV£DW?DV£Hr8®ÄDVÃHrb–ÐDVÃHrb–ÐDW#HráÂpDW?Hs¥,DW?Hs¥,.DW]DV£DW!DW".DV£DW"DW#. Diabetes >=18 and <65 Years and at Risk A B›Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B]ÛèB]IÜmRNA-1273-P301 mRNA-1273-P301-US357-2324US3572324US357USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DW@DV¤Hr9´DVÁHr``ÌDVÁHr``ÌDW%Hrä?ðDW@HsðDW@Hsð.DW]DV¤DWDW.DV¤DW$DW%. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BdmRNA-1273-P301 mRNA-1273-P301-US357-2324US3572324US357USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DW@DV¤Hr9´DVÁHr``ÌDVÁHr``ÌDW%Hrä?ðDW@HsðDW@Hsð.DW]DV¤DWDW.DV¤DW$DW%. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BdBdmômRNA-1273-P301 mRNA-1273-P301-US357-2324US3572324US357USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DW@DV¤Hr9´DVÁHr``ÌDVÁHr``ÌDW%Hrä?ðDW@HsðDW@Hsð.DW]DV¤DWDW.DV¤DW$DW%. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BdmôBdÛèmRNA-1273-P301 mRNA-1273-P301-US357-2327US3572327US357USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV§DVÊDV§Hr=Ï€DVÊHrkÍÌDVÊHrkÍÌ.......DW]DV§...DV§... >=18 and <65 Years and Not at RiskAB”Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBLmRNA-1273-P301 mRNA-1273-P301-US357-2327US3572327US357USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV§DVÊDV§Hr=Ï€DVÊHrkÍÌDVÊHrkÍÌ.......DW]DV§...DV§... >=18 and <65 Years and Not at RiskAB”Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBLBLmômRNA-1273-P301 mRNA-1273-P301-US358-2110US3582110US358USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV£DV¿DV£Hr8ÉôDV¿Hr]²ÈDV¿Hr]²È.......DW]DV£DW6DW7.DV£DW6DW7. Severe Obesity >=18 and <65 Years and at Risk A BŸMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BsmRNA-1273-P301 mRNA-1273-P301-US358-2142US3582142US358USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWRDV™Hr+hDVµHrPaTDVµHrPaTDW7HrûËÔDWRHst€DWRHst€.DW]DV™DW DW!.DV™DW6DW7. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BTmRNA-1273-P301 mRNA-1273-P301-US358-2142US3582142US358USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWRDV™Hr+hDVµHrPaTDVµHrPaTDW7HrûËÔDWRHst€DWRHst€.DW]DV™DW DW!.DV™DW6DW7. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BTBTmômRNA-1273-P301 mRNA-1273-P301-US358-2142US3582142US358USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWRDV™Hr+hDVµHrPaTDVµHrPaTDW7HrûËÔDWRHst€DWRHst€.DW]DV™DW DW!.DV™DW6DW7. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BTmôBTÛèmRNA-1273-P301 mRNA-1273-P301-US358-2142US3582142US358USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWRDV™Hr+hDVµHrPaTDVµHrPaTDW7HrûËÔDWRHst€DWRHst€.DW]DV™DW DW!.DV™DW6DW7. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BTÛèBTIÜmRNA-1273-P301 mRNA-1273-P301-US359-2014US3592014US359USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWUDVtHqúçØDV’Hr" 4DV’Hr" 4DW8Hrüî8DWUHs#„DWUHs#„.DW]DVtDW7DW8.DVtDW7DW8. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBdmRNA-1273-P301 mRNA-1273-P301-US359-2014US3592014US359USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWUDVtHqúçØDV’Hr" 4DV’Hr" 4DW8Hrüî8DWUHs#„DWUHs#„.DW]DVtDW7DW8.DVtDW7DW8. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBdBdmômRNA-1273-P301 mRNA-1273-P301-US359-2053US3592053US359USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWDDVvHqý† DV’Hr"%ÜDV’Hr"%ÜDW(HrçÆÀDWDHsö˜DWDHsö˜.DW]DVvDW'DW(.DVvDW'DW(. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BtmRNA-1273-P301 mRNA-1273-P301-US359-2053US3592053US359USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWDDVvHqý† DV’Hr"%ÜDV’Hr"%ÜDW(HrçÆÀDWDHsö˜DWDHsö˜.DW]DVvDW'DW(.DVvDW'DW(. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BtBtmômRNA-1273-P301 mRNA-1273-P301-US359-2053US3592053US359USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWDDVvHqý† DV’Hr"%ÜDV’Hr"%ÜDW(HrçÆÀDWDHsö˜DWDHsö˜.DW]DVvDW'DW(.DVvDW'DW(. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BtmôBtÛèmRNA-1273-P301 mRNA-1273-P301-US359-2053US3592053US359USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWDDVvHqý† DV’Hr"%ÜDV’Hr"%ÜDW(HrçÆÀDWDHsö˜DWDHsö˜.DW]DVvDW'DW(.DVvDW'DW(. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BtÛèBtIÜmRNA-1273-P301 mRNA-1273-P301-US359-2063US3592063US359USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWEDVwHqþ{ŒDV“Hr#XäDV“Hr#XäDWEHsKœDWEHsKœ...DW]DVwDWDDWE.DVwDWDDWE. >=18 and <65 Years and Not at RiskABËNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B«mRNA-1273-P301 mRNA-1273-P301-US359-2063US3592063US359USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWEDVwHqþ{ŒDV“Hr#XäDV“Hr#XäDWEHsKœDWEHsKœ...DW]DVwDWDDWE.DVwDWDDWE. >=18 and <65 Years and Not at RiskABËNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B«B«mðmRNA-1273-P301 mRNA-1273-P301-US359-2063US3592063US359USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWEDVwHqþ{ŒDV“Hr#XäDV“Hr#XäDWEHsKœDWEHsKœ...DW]DVwDWDDWE.DVwDWDDWE. >=18 and <65 Years and Not at RiskABËNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B«mðB«ÛèmRNA-1273-P301 mRNA-1273-P301-US359-2075US3592075US359USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWFDVwHqþ½,DV“Hr#z¤DV“Hr#z¤DW(Hrè¤DWFHs‹ˆDWFHs‹ˆ.DW]DVwDW'DW(.DVwDW'DW(. >=65 Years A0BËNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BŽmRNA-1273-P301 mRNA-1273-P301-US359-2075US3592075US359USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWFDVwHqþ½,DV“Hr#z¤DV“Hr#z¤DW(Hrè¤DWFHs‹ˆDWFHs‹ˆ.DW]DVwDW'DW(.DVwDW'DW(. >=65 Years A0BËNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BŽBŽmðmRNA-1273-P301 mRNA-1273-P301-US359-2075US3592075US359USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVwDWFDVwHqþ½,DV“Hr#z¤DV“Hr#z¤DW(Hrè¤DWFHs‹ˆDWFHs‹ˆ.DW]DVwDW'DW(.DVwDW'DW(. >=65 Years A0BËNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BŽmðBŽÛèmRNA-1273-P301 mRNA-1273-P301-US359-2083US3592083US359USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVxDW[DVxHqÿ×˜DV”Hr$¨üDV”Hr$¨üDW?Hs HDW[Hs+LDW[Hs+L.DW]DVxDW>DW?.DVxDW>DW?.Chronic Lung Disease >=18 and <65 Years and at Risk A BÊNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B«mRNA-1273-P301 mRNA-1273-P301-US359-2083US3592083US359USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVxDW[DVxHqÿ×˜DV”Hr$¨üDV”Hr$¨üDW?Hs HDW[Hs+LDW[Hs+L.DW]DVxDW>DW?.DVxDW>DW?.Chronic Lung Disease >=18 and <65 Years and at Risk A BÊNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B«B«mðmRNA-1273-P301 mRNA-1273-P301-US359-2083US3592083US359USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVxDW[DVxHqÿ×˜DV”Hr$¨üDV”Hr$¨üDW?Hs HDW[Hs+LDW[Hs+L.DW]DVxDW>DW?.DVxDW>DW?.Chronic Lung Disease >=18 and <65 Years and at Risk A BÊNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B«mðB«ÛèmRNA-1273-P301 mRNA-1273-P301-US359-2083US3592083US359USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVxDW[DVxHqÿ×˜DV”Hr$¨üDV”Hr$¨üDW?Hs HDW[Hs+LDW[Hs+L.DW]DVxDW>DW?.DVxDW>DW?.Chronic Lung Disease >=18 and <65 Years and at Risk A BÊNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B«ÛèB«IØmRNA-1273-P301 mRNA-1273-P301-US359-2084US3592084US359USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVxDW@DVxHqÿäôDV”Hr$¹ DV”Hr$¹ DW$HrâÞDW@Hs¿˜DW@Hs¿˜.DW]DVxDW#DW$.DVxDW#DW$. Severe Obesity >=18 and <65 Years and at Risk A BÊNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BVmRNA-1273-P301 mRNA-1273-P301-US359-2084US3592084US359USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVxDW@DVxHqÿäôDV”Hr$¹ DV”Hr$¹ DW$HrâÞDW@Hs¿˜DW@Hs¿˜.DW]DVxDW#DW$.DVxDW#DW$. Severe Obesity >=18 and <65 Years and at Risk A BÊNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BVBVmômRNA-1273-P301 mRNA-1273-P301-US359-2084US3592084US359USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVxDW@DVxHqÿäôDV”Hr$¹ DV”Hr$¹ DW$HrâÞDW@Hs¿˜DW@Hs¿˜.DW]DVxDW#DW$.DVxDW#DW$. Severe Obesity >=18 and <65 Years and at Risk A BÊNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BVmôBVÛèmRNA-1273-P301 mRNA-1273-P301-US359-2084US3592084US359USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVxDW@DVxHqÿäôDV”Hr$¹ DV”Hr$¹ DW$HrâÞDW@Hs¿˜DW@Hs¿˜.DW]DVxDW#DW$.DVxDW#DW$. Severe Obesity >=18 and <65 Years and at Risk A BÊNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BVÛèBVIÜmRNA-1273-P301 mRNA-1273-P301-US359-2117US3592117US359USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWADVzHr’DV–Hr'¥HDV–Hr'¥HDW%HrãÏèDWAHsûˆDWAHsûˆ.DW]DVzDW$DW%.DVzDW$DW%. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBWmRNA-1273-P301 mRNA-1273-P301-US359-2117US3592117US359USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWADVzHr’DV–Hr'¥HDV–Hr'¥HDW%HrãÏèDWAHsûˆDWAHsûˆ.DW]DVzDW$DW%.DVzDW$DW%. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBWBWmômRNA-1273-P301 mRNA-1273-P301-US359-2127US3592127US359USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW@DVzHrÙDV˜Hr*X°DV˜Hr*X°DWHrÐHìDW@HsˆDW@Hsˆ.DW]DVzDWDW.DVzDWDW. Diabetes >=18 and <65 Years and at Risk A BÆNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B^mRNA-1273-P301 mRNA-1273-P301-US359-2127US3592127US359USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW@DVzHrÙDV˜Hr*X°DV˜Hr*X°DWHrÐHìDW@HsˆDW@Hsˆ.DW]DVzDWDW.DVzDWDW. Diabetes >=18 and <65 Years and at Risk A BÆNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B^B^mômRNA-1273-P301 mRNA-1273-P301-US359-2127US3592127US359USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW@DVzHrÙDV˜Hr*X°DV˜Hr*X°DWHrÐHìDW@HsˆDW@Hsˆ.DW]DVzDWDW.DVzDWDW. Diabetes >=18 and <65 Years and at Risk A BÆNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B^môB^ÛèmRNA-1273-P301 mRNA-1273-P301-US359-2132US3592132US359USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWDDV{HrØÀDV—Hr(¤DV—Hr(¤DW(Hrè´DWDHsÆPDWDHsÆP.DW]DV{DW'DW(.DV{DW'DW(. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BLmRNA-1273-P301 mRNA-1273-P301-US359-2159US3592159US359USAB.YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrlHDV™Hr+JDV™Hr+J.......DW]DV}DW/DW0.DV}DW/DW0. Severe Obesity >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB‚mRNA-1273-P301 mRNA-1273-P301-US359-2159US3592159US359USAB.YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrlHDV™Hr+JDV™Hr+J.......DW]DV}DW/DW0.DV}DW/DW0. Severe Obesity >=18 and <65 Years and at Risk A BÅNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB‚B‚mðmRNA-1273-P301 mRNA-1273-P301-US359-2161US3592161US359USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrsDV™Hr+’üDV™Hr+’ü.......DW]DV}DW(DW).DV}DW(DW). >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BPmRNA-1273-P301 mRNA-1273-P301-US359-2161US3592161US359USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrsDV™Hr+’üDV™Hr+’ü.......DW]DV}DW(DW).DV}DW(DW). >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BPBPmômRNA-1273-P301 mRNA-1273-P301-US359-2161US3592161US359USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrsDV™Hr+’üDV™Hr+’ü.......DW]DV}DW(DW).DV}DW(DW). >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BPmôBPÛèmRNA-1273-P301 mRNA-1273-P301-US359-2161US3592161US359USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrsDV™Hr+’üDV™Hr+’ü.......DW]DV}DW(DW).DV}DW(DW). >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BPÛèBPIÜmRNA-1273-P301 mRNA-1273-P301-US359-2189US3592189US359USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DWADV~HrTDVšHr,}ÔDVšHr,}ÔDW%HrãÅ DWAHs¾\DWAHs¾\.DW]DV~DW$DW%.DV~DW$DW%. >=18 and <65 Years and Not at RiskABÄNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BSmRNA-1273-P301 mRNA-1273-P301-US359-2197US3592197US359USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDVœDVHr ”DVœHr/UTDVœHr/UT.......DW]DVDW(DW).DVDW(DW). >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB;mRNA-1273-P301 mRNA-1273-P301-US359-2197US3592197US359USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDVœDVHr ”DVœHr/UTDVœHr/UT.......DW]DVDW(DW).DVDW(DW). >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB;B;mômRNA-1273-P301 mRNA-1273-P301-US360-2034US3602034US360USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE UNKNOWN YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW6DV™Hr+‰œDVµHrPnìDVµHrPnìDWHrÖåXDW6Hrú˜DW6Hrú˜.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB/mRNA-1273-P301 mRNA-1273-P301-US360-2034US3602034US360USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE UNKNOWN YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW6DV™Hr+‰œDVµHrPnìDVµHrPnìDWHrÖåXDW6Hrú˜DW6Hrú˜.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB/B/mômRNA-1273-P301 mRNA-1273-P301-US360-2038US3602038US360USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWODVœHr/ŠLDV¿Hr]‡äDV¿Hr]‡äDW,HríI8DWOHsaLDWOHsaL.DW]DVœDW+DW,.DVœDW+DW,. >=18 and <65 Years and Not at RiskABŸNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B8mRNA-1273-P301 mRNA-1273-P301-US360-2038US3602038US360USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWODVœHr/ŠLDV¿Hr]‡äDV¿Hr]‡äDW,HríI8DWOHsaLDWOHsaL.DW]DVœDW+DW,.DVœDW+DW,. >=18 and <65 Years and Not at RiskABŸNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B8B8mômRNA-1273-P301 mRNA-1273-P301-US360-2038US3602038US360USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWODVœHr/ŠLDV¿Hr]‡äDV¿Hr]‡äDW,HríI8DWOHsaLDWOHsaL.DW]DVœDW+DW,.DVœDW+DW,. >=18 and <65 Years and Not at RiskABŸNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B8môB8ÛæmRNA-1273-P301 mRNA-1273-P301-US360-2038US3602038US360USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWODVœHr/ŠLDV¿Hr]‡äDV¿Hr]‡äDW,HríI8DWOHsaLDWOHsaL.DW]DVœDW+DW,.DVœDW+DW,. >=18 and <65 Years and Not at RiskABŸNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B8ÛæB8IÚmRNA-1273-P301 mRNA-1273-P301-US360-2116US3602116US360USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DWODV¬HrDÃÐDVÉHrjÔlDVÉHrjÔlDWOHsrhDWOHsrh...DW]DV¬DW7DW8.DV¬DWNDWO. >=18 and <65 Years and Not at RiskAB•Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBpmRNA-1273-P301 mRNA-1273-P301-US360-2116US3602116US360USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DWODV¬HrDÃÐDVÉHrjÔlDVÉHrjÔlDWOHsrhDWOHsrh...DW]DV¬DW7DW8.DV¬DWNDWO. >=18 and <65 Years and Not at RiskAB•Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBpBpmômRNA-1273-P301 mRNA-1273-P301-US361-2031US3612031US361USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWADV˜Hr)üDV²HrL]\DV²HrL]\DW%HrãÞ¬DWAHsÆTDWAHsÆT.DW]DV˜DW$DW%.DV˜DW$DW%. >=65 Years A0B¬Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmmRNA-1273-P301 mRNA-1273-P301-US361-2031US3612031US361USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWADV˜Hr)üDV²HrL]\DV²HrL]\DW%HrãÞ¬DWAHsÆTDWAHsÆT.DW]DV˜DW$DW%.DV˜DW$DW%. >=65 Years A0B¬Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BmBmmômRNA-1273-P301 mRNA-1273-P301-US361-2031US3612031US361USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWADV˜Hr)üDV²HrL]\DV²HrL]\DW%HrãÞ¬DWAHsÆTDWAHsÆT.DW]DV˜DW$DW%.DV˜DW$DW%. >=65 Years A0B¬Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmmôBmÛèmRNA-1273-P301 mRNA-1273-P301-US361-2037US3612037US361USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNNYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWODVœHr/0ˆDV¸HrT"DV¸HrT"DW,HríøDWOHsSðDWOHsSð.DW]DVœDW+DW,.DVœDW+DW,. >=18 and <65 Years and Not at RiskAB¦Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBemRNA-1273-P301 mRNA-1273-P301-US361-2037US3612037US361USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNNYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWODVœHr/0ˆDV¸HrT"DV¸HrT"DW,HríøDWOHsSðDWOHsSð.DW]DVœDW+DW,.DVœDW+DW,. >=18 and <65 Years and Not at RiskAB¦Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBeBemômRNA-1273-P301 mRNA-1273-P301-US361-2052US3612052US361USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV§DWADV§Hr=Í(DVÆHrf”°DVÆHrf”°DWHrÚ¥XDWAHsº$DWAHsº$.DW]DV§DWDW.DV§DWDW. Significant Cardiac Disease >=65 Years A0B˜Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBTmRNA-1273-P301 mRNA-1273-P301-US361-2052US3612052US361USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV§DWADV§Hr=Í(DVÆHrf”°DVÆHrf”°DWHrÚ¥XDWAHsº$DWAHsº$.DW]DV§DWDW.DV§DWDW. Significant Cardiac Disease >=65 Years A0B˜Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBTBTmômRNA-1273-P301 mRNA-1273-P301-US361-2082US3612082US361USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDWADVÂHraž$DVÜHrƒÕèDVÜHrƒÕèDW%HräHDWAHsýhDWAHsýh.DW]DVÂDW$DW%.DVÂDW$DW%. >=18 and <65 Years and Not at RiskAB‚Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BDmRNA-1273-P301 mRNA-1273-P301-US361-2082US3612082US361USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDWADVÂHraž$DVÜHrƒÕèDVÜHrƒÕèDW%HräHDWAHsýhDWAHsýh.DW]DVÂDW$DW%.DVÂDW$DW%. >=18 and <65 Years and Not at RiskAB‚Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BDBDmômRNA-1273-P301 mRNA-1273-P301-US361-2082US3612082US361USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDWADVÂHraž$DVÜHrƒÕèDVÜHrƒÕèDW%HräHDWAHsýhDWAHsýh.DW]DVÂDW$DW%.DVÂDW$DW%. >=18 and <65 Years and Not at RiskAB‚Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BDmôBDÛèmRNA-1273-P301 mRNA-1273-P301-US362-2115US3622115US362USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWRDVŽHrÁ DVªHrA¢¸DVªHrA¢¸DW7Hrû¨DWRHsäDWRHsä.DW]DVŽDW5DW6.DVŽDW6DW7. Diabetes >=18 and <65 Years and at Risk A B´Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‡mRNA-1273-P301 mRNA-1273-P301-US362-2115US3622115US362USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWRDVŽHrÁ DVªHrA¢¸DVªHrA¢¸DW7Hrû¨DWRHsäDWRHsä.DW]DVŽDW5DW6.DVŽDW6DW7. Diabetes >=18 and <65 Years and at Risk A B´Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‡B‡mðmRNA-1273-P301 mRNA-1273-P301-US362-2115US3622115US362USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWRDVŽHrÁ DVªHrA¢¸DVªHrA¢¸DW7Hrû¨DWRHsäDWRHsä.DW]DVŽDW5DW6.DVŽDW6DW7. Diabetes >=18 and <65 Years and at Risk A B´Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‡mðB‡ÛèmRNA-1273-P301 mRNA-1273-P301-US362-2249US3622249US362USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW7DVHrEÇ€DVÍHroÓàDVÍHroÓàDWHrÖŸ€DW7Hrûq\DW7Hrûq\.DW]DVDWDW.DVDWDW. Diabetes >=18 and <65 Years and at Risk A B‘Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BEmRNA-1273-P301 mRNA-1273-P301-US362-2249US3622249US362USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW7DVHrEÇ€DVÍHroÓàDVÍHroÓàDWHrÖŸ€DW7Hrûq\DW7Hrûq\.DW]DVDWDW.DVDWDW. Diabetes >=18 and <65 Years and at Risk A B‘Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BEBEmômRNA-1273-P301 mRNA-1273-P301-US362-2249US3622249US362USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW7DVHrEÇ€DVÍHroÓàDVÍHroÓàDWHrÖŸ€DW7Hrûq\DW7Hrûq\.DW]DVDWDW.DVDWDW. Diabetes >=18 and <65 Years and at Risk A B‘Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BEmôBEÛèmRNA-1273-P301 mRNA-1273-P301-US362-2249US3622249US362USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW7DVHrEÇ€DVÍHroÓàDVÍHroÓàDWHrÖŸ€DW7Hrûq\DW7Hrûq\.DW]DVDWDW.DVDWDW. Diabetes >=18 and <65 Years and at Risk A B‘Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BEÛèBEIÜmRNA-1273-P301 mRNA-1273-P301-US362-2257US3622257US362USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV²DW2DV²HrLQàDVÏHrräDVÏHrräDWHrÐM$DW2Hrôë¬DW2Hrôë¬.DW]DV²DWDW.DV²DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B#mRNA-1273-P301 mRNA-1273-P301-US362-2263US3622263US362USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¶DWRDV¶HrQ¢¨DVØHr~ŒdDVØHr~ŒdDW3Hrö€èDWRHsUDWRHsU.DW]DV¶DW+DW,.DV¶DW2DW3. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BVmRNA-1273-P301 mRNA-1273-P301-US362-2263US3622263US362USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¶DWRDV¶HrQ¢¨DVØHr~ŒdDVØHr~ŒdDW3Hrö€èDWRHsUDWRHsU.DW]DV¶DW+DW,.DV¶DW2DW3. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BVBVmômRNA-1273-P301 mRNA-1273-P301-US362-2263US3622263US362USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¶DWRDV¶HrQ¢¨DVØHr~ŒdDVØHr~ŒdDW3Hrö€èDWRHsUDWRHsU.DW]DV¶DW+DW,.DV¶DW2DW3. >=18 and <65 Years and Not at RiskAB†Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BVmôBVÛèmRNA-1273-P301 mRNA-1273-P301-US363-2018US3632018US363USAB8YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW9DVŠHrÓ„DV¤Hr9üDV¤Hr9üDWHrÚ¦HDW9HrþD,DW9HrþD,.DW]DVŠDWDW.DVŠDWDW. >=18 and <65 Years and Not at RiskABºMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BumRNA-1273-P301 mRNA-1273-P301-US363-2039US3632039US363USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW3DVHrÆ DV¬HrD¤hDV¬HrD¤hDWHrÑ§PDW3Hrö’|DW3Hrö’|.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BimRNA-1273-P301 mRNA-1273-P301-US363-2039US3632039US363USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW3DVHrÆ DV¬HrD¤hDV¬HrD¤hDWHrÑ§PDW3Hrö’|DW3Hrö’|.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BiBimômRNA-1273-P301 mRNA-1273-P301-US363-2039US3632039US363USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW3DVHrÆ DV¬HrD¤hDV¬HrD¤hDWHrÑ§PDW3Hrö’|DW3Hrö’|.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BimôBiÛèmRNA-1273-P301 mRNA-1273-P301-US363-2039US3632039US363USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW3DVHrÆ DV¬HrD¤hDV¬HrD¤hDWHrÑ§PDW3Hrö’|DW3Hrö’|.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BiÛèBiIÜmRNA-1273-P301 mRNA-1273-P301-US363-2114US3632114US363USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV²DW3DV²HrLOˆDVÑHruDVÑHruDWHrÑ¨DW3Hrö‘ŒDW3Hrö‘Œ.DW]DV²DWDW.DV²DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBEmRNA-1273-P301 mRNA-1273-P301-US363-2114US3632114US363USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV²DW3DV²HrLOˆDVÑHruDVÑHruDWHrÑ¨DW3Hrö‘ŒDW3Hrö‘Œ.DW]DV²DWDW.DV²DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBEBEmômRNA-1273-P301 mRNA-1273-P301-US363-2116US3632116US363USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DW+DV³HrM DVÏHrrÆDVÏHrrÆDWHrÆÜDW+HrëÜˆDW+HrëÜˆ.DW]DV³DWDW.DV³DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B6mRNA-1273-P301 mRNA-1273-P301-US363-2116US3632116US363USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DW+DV³HrM DVÏHrrÆDVÏHrrÆDWHrÆÜDW+HrëÜˆDW+HrëÜˆ.DW]DV³DWDW.DV³DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B6B6mômRNA-1273-P301 mRNA-1273-P301-US363-2116US3632116US363USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DW+DV³HrM DVÏHrrÆDVÏHrrÆDWHrÆÜDW+HrëÜˆDW+HrëÜˆ.DW]DV³DWDW.DV³DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B6môB6ÛæmRNA-1273-P301 mRNA-1273-P301-US363-2116US3632116US363USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DW+DV³HrM DVÏHrrÆDVÏHrrÆDWHrÆÜDW+HrëÜˆDW+HrëÜˆ.DW]DV³DWDW.DV³DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B6ÛæB6IÚmRNA-1273-P301 mRNA-1273-P301-US363-2119US3632119US363USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV´DVÎDV´HrNì¬DVÎHrq2DVÎHrq2.......DW]DV´DWDW.DV´DWDW. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B7mRNA-1273-P301 mRNA-1273-P301-US363-2129US3632129US363USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVºDW+DVºHrWÌDVÕHrznàDVÕHrznàDWHrÆÝpDW+HrëØDW+HrëØ.DW]DVºDWDW.DVºDWDW. >=18 and <65 Years and Not at RiskAB‰Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US363-2129US3632129US363USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVºDW+DVºHrWÌDVÕHrznàDVÕHrznàDWHrÆÝpDW+HrëØDW+HrëØ.DW]DVºDWDW.DVºDWDW. >=18 and <65 Years and Not at RiskAB‰Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmómRNA-1273-P301 mRNA-1273-P301-US363-2129US3632129US363USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVºDW+DVºHrWÌDVÕHrznàDVÕHrznàDWHrÆÝpDW+HrëØDW+HrëØ.DW]DVºDWDW.DVºDWDW. >=18 and <65 Years and Not at RiskAB‰Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmóBÛçmRNA-1273-P301 mRNA-1273-P301-US363-2134US3632134US363USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV»DW9DV»HrX5xDV×Hr}L´DV×Hr}L´DWHrÚ¦üDW9Hrþ/DW9Hrþ/.DW]DV»DWDW.DV»DWDW. >=18 and <65 Years and Not at RiskAB‡Minority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BHmRNA-1273-P301 mRNA-1273-P301-US363-2154US3632154US363USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDW9DVÂHra—ÐDVÞHr†’°DVÞHr†’°DWHrÚ¥XDW9Hrþ{ôDW9Hrþ{ô.DW]DVÂDWDW.DVÂDWDW. Severe Obesity >=18 and <65 Years and at Risk A B€Minority Non-caucasianA At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B1mRNA-1273-P301 mRNA-1273-P301-US363-2154US3632154US363USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDW9DVÂHra—ÐDVÞHr†’°DVÞHr†’°DWHrÚ¥XDW9Hrþ{ôDW9Hrþ{ô.DW]DVÂDWDW.DVÂDWDW. Severe Obesity >=18 and <65 Years and at Risk A B€Minority Non-caucasianA At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B1B1mômRNA-1273-P301 mRNA-1273-P301-US363-2154US3632154US363USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDW9DVÂHra—ÐDVÞHr†’°DVÞHr†’°DWHrÚ¥XDW9Hrþ{ôDW9Hrþ{ô.DW]DVÂDWDW.DVÂDWDW. Severe Obesity >=18 and <65 Years and at Risk A B€Minority Non-caucasianA At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B1môB1ÛæmRNA-1273-P301 mRNA-1273-P301-US363-2154US3632154US363USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÂDW9DVÂHra—ÐDVÞHr†’°DVÞHr†’°DWHrÚ¥XDW9Hrþ{ôDW9Hrþ{ô.DW]DVÂDWDW.DVÂDWDW. Severe Obesity >=18 and <65 Years and at Risk A B€Minority Non-caucasianA At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B1ÛæB1IÚmRNA-1273-P301 mRNA-1273-P301-US364-2086US3642086US364USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHrÂ`DVHrEë\DVHrEë\DWHrØBÌDW?HsV0DW?HsV0.DW]DVDWDW.DVDWDW. Diabetes >=18 and <65 Years and at Risk A B±Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BomRNA-1273-P301 mRNA-1273-P301-US364-2086US3642086US364USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHrÂ`DVHrEë\DVHrEë\DWHrØBÌDW?HsV0DW?HsV0.DW]DVDWDW.DVDWDW. Diabetes >=18 and <65 Years and at Risk A B±Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BoBomômRNA-1273-P301 mRNA-1273-P301-US364-2086US3642086US364USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHrÂ`DVHrEë\DVHrEë\DWHrØBÌDW?HsV0DW?HsV0.DW]DVDWDW.DVDWDW. Diabetes >=18 and <65 Years and at Risk A B±Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BomôBoÛèmRNA-1273-P301 mRNA-1273-P301-US364-2086US3642086US364USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHrÂ`DVHrEë\DVHrEë\DWHrØBÌDW?HsV0DW?HsV0.DW]DVDWDW.DVDWDW. Diabetes >=18 and <65 Years and at Risk A B±Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BoÛèBoIÜmRNA-1273-P301 mRNA-1273-P301-US364-2152US3642152US364USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV—DV´DV—Hr)|DV´HrO;äDV´HrO;ä......DWDWDV—DVÿDWDWDV—DVÿDWDWChronic Lung Disease >=18 and <65 Years and at Risk A BMNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BSmRNA-1273-P301 mRNA-1273-P301-US364-2152US3642152US364USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV—DV´DV—Hr)|DV´HrO;äDV´HrO;ä......DWDWDV—DVÿDWDWDV—DVÿDWDWChronic Lung Disease >=18 and <65 Years and at Risk A BMNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BSBSmômRNA-1273-P301 mRNA-1273-P301-US364-2152US3642152US364USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV—DV´DV—Hr)|DV´HrO;äDV´HrO;ä......DWDWDV—DVÿDWDWDV—DVÿDWDWChronic Lung Disease >=18 and <65 Years and at Risk A BMNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BSmôBSÛèmRNA-1273-P301 mRNA-1273-P301-US364-2152US3642152US364USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV—DV´DV—Hr)|DV´HrO;äDV´HrO;ä......DWDWDV—DVÿDWDWDV—DVÿDWDWChronic Lung Disease >=18 and <65 Years and at Risk A BMNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BSÛèBSIÜmRNA-1273-P301 mRNA-1273-P301-US364-2212US3642212US364USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDW4DVœHr/žìDV¸HrTmøDV¸HrTmøDWHrÓDW4Hr÷ÌDW4Hr÷Ì.DW]DVœDWDW.DVœDWDW. >=18 and <65 Years and Not at RiskAB¦Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B[mRNA-1273-P301 mRNA-1273-P301-US364-2212US3642212US364USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDW4DVœHr/žìDV¸HrTmøDV¸HrTmøDWHrÓDW4Hr÷ÌDW4Hr÷Ì.DW]DVœDWDW.DVœDWDW. >=18 and <65 Years and Not at RiskAB¦Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B[B[mômRNA-1273-P301 mRNA-1273-P301-US364-2212US3642212US364USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDW4DVœHr/žìDV¸HrTmøDV¸HrTmøDWHrÓDW4Hr÷ÌDW4Hr÷Ì.DW]DVœDWDW.DVœDWDW. >=18 and <65 Years and Not at RiskAB¦Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B[môB[ÛèmRNA-1273-P301 mRNA-1273-P301-US364-2212US3642212US364USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDW4DVœHr/žìDV¸HrTmøDV¸HrTmøDWHrÓDW4Hr÷ÌDW4Hr÷Ì.DW]DVœDWDW.DVœDWDW. >=18 and <65 Years and Not at RiskAB¦Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B[ÛèB[IÜmRNA-1273-P301 mRNA-1273-P301-US364-2224US3642224US364USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr2,\DV½Hr[DV½Hr[DWHrÚÉèDW;HsHDW;HsH.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskAB¡Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BVmRNA-1273-P301 mRNA-1273-P301-US364-2224US3642224US364USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr2,\DV½Hr[DV½Hr[DWHrÚÉèDW;HsHDW;HsH.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskAB¡Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BVBVmômRNA-1273-P301 mRNA-1273-P301-US364-2224US3642224US364USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr2,\DV½Hr[DV½Hr[DWHrÚÉèDW;HsHDW;HsH.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskAB¡Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BVmôBVÛèmRNA-1273-P301 mRNA-1273-P301-US364-2224US3642224US364USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr2,\DV½Hr[DV½Hr[DWHrÚÉèDW;HsHDW;HsH.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskAB¡Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BVÛèBVIÜmRNA-1273-P301 mRNA-1273-P301-US364-2227US3642227US364USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr24ÌDVÀHr^ÿ\DVÀHr^ÿ\DWHrÛç$DW;Hsñ@DW;Hsñ@.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskABžMinority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BAmRNA-1273-P301 mRNA-1273-P301-US364-2227US3642227US364USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr24ÌDVÀHr^ÿ\DVÀHr^ÿ\DWHrÛç$DW;Hsñ@DW;Hsñ@.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskABžMinority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BABAmômRNA-1273-P301 mRNA-1273-P301-US364-2227US3642227US364USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr24ÌDVÀHr^ÿ\DVÀHr^ÿ\DWHrÛç$DW;Hsñ@DW;Hsñ@.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskABžMinority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BAmôBAÛèmRNA-1273-P301 mRNA-1273-P301-US364-2227US3642227US364USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr24ÌDVÀHr^ÿ\DVÀHr^ÿ\DWHrÛç$DW;Hsñ@DW;Hsñ@.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskABžMinority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BAÛèBAIÜmRNA-1273-P301 mRNA-1273-P301-US364-2229US3642229US364USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr2;˜DVÀHr_ðDVÀHr_ðDWHrÛë DW;HsðPDW;HsðP.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskABžMinority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B?mRNA-1273-P301 mRNA-1273-P301-US364-2229US3642229US364USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr2;˜DVÀHr_ðDVÀHr_ðDWHrÛë DW;HsðPDW;HsðP.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskABžMinority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B?B?mômRNA-1273-P301 mRNA-1273-P301-US364-2229US3642229US364USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr2;˜DVÀHr_ðDVÀHr_ðDWHrÛë DW;HsðPDW;HsðP.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskABžMinority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B?môB?ÛæmRNA-1273-P301 mRNA-1273-P301-US364-2229US3642229US364USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW;DVžHr2;˜DVÀHr_ðDVÀHr_ðDWHrÛë DW;HsðPDW;HsðP.DW]DVžDWDW.DVžDWDW. >=18 and <65 Years and Not at RiskABžMinority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B?ÛæB?IÚmRNA-1273-P301 mRNA-1273-P301-US364-2345US3642345US364USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW;DVÃHrbüÄDVßHr‡èhDVßHr‡èhDWHrÚÎ\DW;Hs„DW;Hs„.DW]DVÃDWDW.DVÃDWDW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B.mRNA-1273-P301 mRNA-1273-P301-US364-2345US3642345US364USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW;DVÃHrbüÄDVßHr‡èhDVßHr‡èhDWHrÚÎ\DW;Hs„DW;Hs„.DW]DVÃDWDW.DVÃDWDW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B.B.mômRNA-1273-P301 mRNA-1273-P301-US364-2345US3642345US364USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW;DVÃHrbüÄDVßHr‡èhDVßHr‡èhDWHrÚÎ\DW;Hs„DW;Hs„.DW]DVÃDWDW.DVÃDWDW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B.môB.ÛæmRNA-1273-P301 mRNA-1273-P301-US364-2345US3642345US364USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW;DVÃHrbüÄDVßHr‡èhDVßHr‡èhDWHrÚÎ\DW;Hs„DW;Hs„.DW]DVÃDWDW.DVÃDWDW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B.ÛæB.IÚmRNA-1273-P301 mRNA-1273-P301-US366-2030US3662030US366USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW:DV–Hr'ŽDV³HrMÒ@DV³HrMÒ@DWHrØI DW:Hrÿ²DW:Hrÿ².DW]DV–DWDW.DV–DWDW. >=18 and <65 Years and Not at RiskAB«Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BnmRNA-1273-P301 mRNA-1273-P301-US366-2041US3662041US366USABJYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYYYYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW?DV–Hr'[8DV±HrJçÄDV±HrJçÄDW"HràDW?HsBDDW?HsBD.DW]DV–DW!DW".DV–DW!DW". >=65 Years A0BMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BomRNA-1273-P301 mRNA-1273-P301-US366-2041US3662041US366USABJYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYYYYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW?DV–Hr'[8DV±HrJçÄDV±HrJçÄDW"HràDW?HsBDDW?HsBD.DW]DV–DW!DW".DV–DW!DW". >=65 Years A0BMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BoBomômRNA-1273-P301 mRNA-1273-P301-US366-2041US3662041US366USABJYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYYYYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW?DV–Hr'[8DV±HrJçÄDV±HrJçÄDW"HràDW?HsBDDW?HsBD.DW]DV–DW!DW".DV–DW!DW". >=65 Years A0BMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BomôBoÛèmRNA-1273-P301 mRNA-1273-P301-US366-2098US3662098US366USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW*DVHr0×ÐDV¸HrT1øDV¸HrT1øDWHrÅ¶ DW*Hrê¨ÌDW*Hrê¨Ì.DW]DVDW DW.DVDW DW. Human Immunodeficiency Virus Infection>=18 and <65 Years and at Risk A B¦Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB+mRNA-1273-P301 mRNA-1273-P301-US366-2098US3662098US366USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW*DVHr0×ÐDV¸HrT1øDV¸HrT1øDWHrÅ¶ DW*Hrê¨ÌDW*Hrê¨Ì.DW]DVDW DW.DVDW DW. Human Immunodeficiency Virus Infection>=18 and <65 Years and at Risk A B¦Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB+B+mômRNA-1273-P301 mRNA-1273-P301-US367-2018US3672018US367USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWHDVvHqý#|DV—Hr(–ìDV—Hr(–ìDWHHsòLDWHHsòL...DW]DVvDWGDWH.DVvDWGDWH. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BµmRNA-1273-P301 mRNA-1273-P301-US367-2018US3672018US367USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWHDVvHqý#|DV—Hr(–ìDV—Hr(–ìDWHHsòLDWHHsòL...DW]DVvDWGDWH.DVvDWGDWH. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BµBµmðmRNA-1273-P301 mRNA-1273-P301-US367-2018US3672018US367USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWHDVvHqý#|DV—Hr(–ìDV—Hr(–ìDWHHsòLDWHHsòL...DW]DVvDWGDWH.DVvDWGDWH. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BµmðBµÛèmRNA-1273-P301 mRNA-1273-P301-US367-2018US3672018US367USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWHDVvHqý#|DV—Hr(–ìDV—Hr(–ìDWHHsòLDWHHsòL...DW]DVvDWGDWH.DVvDWGDWH. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BµÛèBµIØmRNA-1273-P301 mRNA-1273-P301-US367-2061US3672061US367USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW]DVzHrÀpDV—Hr(÷|DV—Hr(÷|DW?Hst0DW]Hs-ÒÈDW]Hs-ÒÈ.DW]DVzDW>DW?.DVzDW>DW?. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B_mRNA-1273-P301 mRNA-1273-P301-US367-2074US3672074US367USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV{DV™DV{HrÜøDV™Hr+M`DV™Hr+M`.......DW]DV{DW DW!.DV{DW DW!. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BŠmRNA-1273-P301 mRNA-1273-P301-US367-2074US3672074US367USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV{DV™DV{HrÜøDV™Hr+M`DV™Hr+M`.......DW]DV{DW DW!.DV{DW DW!. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BŠBŠmðmRNA-1273-P301 mRNA-1273-P301-US367-2074US3672074US367USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV{DV™DV{HrÜøDV™Hr+M`DV™Hr+M`.......DW]DV{DW DW!.DV{DW DW!. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BŠmðBŠÛèmRNA-1273-P301 mRNA-1273-P301-US367-2146US3672146US367USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW?DV€Hr @DVHr0¿pDVHr0¿pDW#Hrá;èDW?HsjÐDW?HsjÐ.DW]DV€DW"DW#.DV€DW"DW#. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BYmRNA-1273-P301 mRNA-1273-P301-US367-2230US3672230US367USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDVŸDVƒHrƒ°DVŸHr3}dDVŸHr3}d.......DW]DVƒDW DWDWDVƒDW DWDW >=18 and <65 Years and Not at RiskABpNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B;mRNA-1273-P301 mRNA-1273-P301-US367-2230US3672230US367USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDVŸDVƒHrƒ°DVŸHr3}dDVŸHr3}d.......DW]DVƒDW DWDWDVƒDW DWDW >=18 and <65 Years and Not at RiskABpNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B;B;mômRNA-1273-P301 mRNA-1273-P301-US367-2230US3672230US367USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVƒDVŸDVƒHrƒ°DVŸHr3}dDVŸHr3}d.......DW]DVƒDW DWDWDVƒDW DWDW >=18 and <65 Years and Not at RiskABpNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B;môB;ÛæmRNA-1273-P301 mRNA-1273-P301-US367-2232US3672232US367USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW:DVƒHr‹äDV Hr4Ù¬DV Hr4Ù¬DWHrÙmdDW:Hrÿ¢ÌDW:Hrÿ¢Ì.DW]DVƒDWDW.DVƒDWDW. >=65 Years A0B¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB[mRNA-1273-P301 mRNA-1273-P301-US367-2232US3672232US367USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW:DVƒHr‹äDV Hr4Ù¬DV Hr4Ù¬DWHrÙmdDW:Hrÿ¢ÌDW:Hrÿ¢Ì.DW]DVƒDWDW.DVƒDWDW. >=65 Years A0B¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB[B[mômRNA-1273-P301 mRNA-1273-P301-US367-2243US3672243US367USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWLDV„Hr<DV¦Hr<›ÄDV¦Hr<›ÄDW%HrãÒ|DWLHs?DWLHs?.DW]DV„DW$DW%.DV„DW$DW%. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BWmRNA-1273-P301 mRNA-1273-P301-US367-2243US3672243US367USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWLDV„Hr<DV¦Hr<›ÄDV¦Hr<›ÄDW%HrãÒ|DWLHs?DWLHs?.DW]DV„DW$DW%.DV„DW$DW%. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BWBWmômRNA-1273-P301 mRNA-1273-P301-US367-2243US3672243US367USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWLDV„Hr<DV¦Hr<›ÄDV¦Hr<›ÄDW%HrãÒ|DWLHs?DWLHs?.DW]DV„DW$DW%.DV„DW$DW%. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BWmôBWÛèmRNA-1273-P301 mRNA-1273-P301-US367-2244US3672244US367USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWNDV„HrÀDV Hr4³ðDV Hr4³ðDW"HrßÓèDWNHsÐHDWNHsÐH.DW]DV„DW!DW".DV„DW!DW". >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BSmRNA-1273-P301 mRNA-1273-P301-US367-2244US3672244US367USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWNDV„HrÀDV Hr4³ðDV Hr4³ðDW"HrßÓèDWNHsÐHDWNHsÐH.DW]DV„DW!DW".DV„DW!DW". >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BSBSmômRNA-1273-P301 mRNA-1273-P301-US367-2244US3672244US367USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWNDV„HrÀDV Hr4³ðDV Hr4³ðDW"HrßÓèDWNHsÐHDWNHsÐH.DW]DV„DW!DW".DV„DW!DW". >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BSmôBSÛèmRNA-1273-P301 mRNA-1273-P301-US367-2244US3672244US367USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWNDV„HrÀDV Hr4³ðDV Hr4³ðDW"HrßÓèDWNHsÐHDWNHsÐH.DW]DV„DW!DW".DV„DW!DW". >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BSÛèBSIÜmRNA-1273-P301 mRNA-1273-P301-US367-2250US3672250US367USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWADV„HrÐDV Hr4ÌÈDV Hr4ÌÈDW!HrÞ³dDWAHsåøDWAHsåø.DW]DV„DW DW!.DV„DW DW!. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‚mRNA-1273-P301 mRNA-1273-P301-US367-2312US3672312US367USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWJDV‰Hr0ìDV¦Hr<XDV¦Hr<XDW/Hrñ_´DWJHs®œDWJHs®œ.DW]DV‰DW.DW/.DV‰DW.DW/. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB‘mRNA-1273-P301 mRNA-1273-P301-US367-2312US3672312US367USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWJDV‰Hr0ìDV¦Hr<XDV¦Hr<XDW/Hrñ_´DWJHs®œDWJHs®œ.DW]DV‰DW.DW/.DV‰DW.DW/. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB‘B‘mðmRNA-1273-P301 mRNA-1273-P301-US367-2368US3672368US367USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‹DVªDV‹HrµìDVªHrA•˜DVªHrA•˜.......DW]DV‹DW8DW9.DV‹DW8DW9. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmRNA-1273-P301 mRNA-1273-P301-US367-2368US3672368US367USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‹DVªDV‹HrµìDVªHrA•˜DVªHrA•˜.......DW]DV‹DW8DW9.DV‹DW8DW9. >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBmðmRNA-1273-P301 mRNA-1273-P301-US368-2018US3682018US368USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW>DV‰HrapDV¥Hr;DàDV¥Hr;DàDW#HrákDW>HsDW>Hs.DW]DV‰DWDW.DV‰DW"DW#. >=18 and <65 Years and Not at RiskAB¹Minority .Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBkmRNA-1273-P301 mRNA-1273-P301-US368-2018US3682018US368USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW>DV‰HrapDV¥Hr;DàDV¥Hr;DàDW#HrákDW>HsDW>Hs.DW]DV‰DWDW.DV‰DW"DW#. >=18 and <65 Years and Not at RiskAB¹Minority .Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBkBkmômRNA-1273-P301 mRNA-1273-P301-US368-2065US3682065US368USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DWVDV–Hr'oœDV²HrLEtDV²HrLEtDWAHs dDWVHs$Í¸DWVHs$Í¸.DW]DV–DW DW.DV–DW@DWA. >=18 and <65 Years and Not at RiskAB¬Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BvmRNA-1273-P301 mRNA-1273-P301-US368-2065US3682065US368USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DWVDV–Hr'oœDV²HrLEtDV²HrLEtDWAHs dDWVHs$Í¸DWVHs$Í¸.DW]DV–DW DW.DV–DW@DWA. >=18 and <65 Years and Not at RiskAB¬Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BvBvmômRNA-1273-P301 mRNA-1273-P301-US368-2065US3682065US368USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DWVDV–Hr'oœDV²HrLEtDV²HrLEtDWAHs dDWVHs$Í¸DWVHs$Í¸.DW]DV–DW DW.DV–DW@DWA. >=18 and <65 Years and Not at RiskAB¬Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BvmôBvÛèmRNA-1273-P301 mRNA-1273-P301-US368-2197US3682197US368USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DW:DV¹HrUl¼DVÕHrzžìDVÕHrzžìDWHrÙœDDW:Hrÿ’dDW:Hrÿ’d.DW]DV¹DWDW.DV¹DWDW. Liver Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B:mRNA-1273-P301 mRNA-1273-P301-US368-2197US3682197US368USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DW:DV¹HrUl¼DVÕHrzžìDVÕHrzžìDWHrÙœDDW:Hrÿ’dDW:Hrÿ’d.DW]DV¹DWDW.DV¹DWDW. Liver Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B:B:mômRNA-1273-P301 mRNA-1273-P301-US368-2197US3682197US368USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DW:DV¹HrUl¼DVÕHrzžìDVÕHrzžìDWHrÙœDDW:Hrÿ’dDW:Hrÿ’d.DW]DV¹DWDW.DV¹DWDW. Liver Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B:môB:ÛæmRNA-1273-P301 mRNA-1273-P301-US368-2197US3682197US368USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¹DW:DV¹HrUl¼DVÕHrzžìDVÕHrzžìDWHrÙœDDW:Hrÿ’dDW:Hrÿ’d.DW]DV¹DWDW.DV¹DWDW. Liver Disease >=18 and <65 Years and at Risk A B‰Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B:ÛæB:IÚmRNA-1273-P301 mRNA-1273-P301-US369-2096US3692096US369USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWDDV™Hr+f8DV´HrNÞØDV´HrNÞØDW(HrçÔ”DWDHs»ˆDWDHs»ˆ.DW]DV™DW#DW$.DV™DW'DW(. >=18 and <65 Years and Not at RiskABªNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BZmRNA-1273-P301 mRNA-1273-P301-US369-2096US3692096US369USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWDDV™Hr+f8DV´HrNÞØDV´HrNÞØDW(HrçÔ”DWDHs»ˆDWDHs»ˆ.DW]DV™DW#DW$.DV™DW'DW(. >=18 and <65 Years and Not at RiskABªNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BZBZmômRNA-1273-P301 mRNA-1273-P301-US369-2096US3692096US369USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWDDV™Hr+f8DV´HrNÞØDV´HrNÞØDW(HrçÔ”DWDHs»ˆDWDHs»ˆ.DW]DV™DW#DW$.DV™DW'DW(. >=18 and <65 Years and Not at RiskABªNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BZmôBZÛèmRNA-1273-P301 mRNA-1273-P301-US369-2096US3692096US369USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWDDV™Hr+f8DV´HrNÞØDV´HrNÞØDW(HrçÔ”DWDHs»ˆDWDHs»ˆ.DW]DV™DW#DW$.DV™DW'DW(. >=18 and <65 Years and Not at RiskABªNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BZÛèBZIÜmRNA-1273-P301 mRNA-1273-P301-US369-2171US3692171US369USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWRDV±HrK)dDVÑHru'ðDVÑHru'ðDW6HrúHhDWRHs+`DWRHs+`.DW]DV±DWDW.DV±DW5DW6. Severe Obesity >=18 and <65 Years and at Risk A BMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B_mRNA-1273-P301 mRNA-1273-P301-US369-2171US3692171US369USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWRDV±HrK)dDVÑHru'ðDVÑHru'ðDW6HrúHhDWRHs+`DWRHs+`.DW]DV±DWDW.DV±DW5DW6. Severe Obesity >=18 and <65 Years and at Risk A BMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B_B_mômRNA-1273-P301 mRNA-1273-P301-US369-2171US3692171US369USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV±DWRDV±HrK)dDVÑHru'ðDVÑHru'ðDW6HrúHhDWRHs+`DWRHs+`.DW]DV±DWDW.DV±DW5DW6. Severe Obesity >=18 and <65 Years and at Risk A BMinority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B_môB_ÛèmRNA-1273-P301 mRNA-1273-P301-US370-2051US3702051US370USAB+YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWVDV®HrG øDVÍHroé¬DVÍHroé¬DW3HröƒDWVHs$’0DWVHs$’0.DW]DV®DW2DW3.DV®DW2DW3. Severe Obesity >=18 and <65 Years and at Risk A B‘Minority .At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B`mRNA-1273-P301 mRNA-1273-P301-US370-2051US3702051US370USAB+YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWVDV®HrG øDVÍHroé¬DVÍHroé¬DW3HröƒDWVHs$’0DWVHs$’0.DW]DV®DW2DW3.DV®DW2DW3. Severe Obesity >=18 and <65 Years and at Risk A B‘Minority .At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B`B`mômRNA-1273-P301 mRNA-1273-P301-US370-2051US3702051US370USAB+YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWVDV®HrG øDVÍHroé¬DVÍHroé¬DW3HröƒDWVHs$’0DWVHs$’0.DW]DV®DW2DW3.DV®DW2DW3. Severe Obesity >=18 and <65 Years and at Risk A B‘Minority .At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B`môB`ÛèmRNA-1273-P301 mRNA-1273-P301-US370-2051US3702051US370USAB+YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV®DWVDV®HrG øDVÍHroé¬DVÍHroé¬DW3HröƒDWVHs$’0DWVHs$’0.DW]DV®DW2DW3.DV®DW2DW3. Severe Obesity >=18 and <65 Years and at Risk A B‘Minority .At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B`ÛèB`IÜmRNA-1273-P301 mRNA-1273-P301-US371-2025US3712025US371USABJYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWGDV˜Hr*¼DV³HrM‘TDV³HrM‘TDWGHsµäDWGHsµä...DW]DV˜DWFDWG.DV˜DWFDWG. >=65 Years A0B«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBumRNA-1273-P301 mRNA-1273-P301-US371-2025US3712025US371USABJYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWGDV˜Hr*¼DV³HrM‘TDV³HrM‘TDWGHsµäDWGHsµä...DW]DV˜DWFDWG.DV˜DWFDWG. >=65 Years A0B«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBuBumômRNA-1273-P301 mRNA-1273-P301-US371-2058US3712058US371USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDV¹DVHr0ª”DV¹HrU€äDV¹HrU€ä.......DW]DVDW(DW).DVDW(DW). >=65 Years A0B¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B>mRNA-1273-P301 mRNA-1273-P301-US371-2059US3712059US371USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVªDWFDVªHrAÊÌDVÈHriG DVÈHriG DWFHs“DWFHs“...DW]DVªDWEDWF.DVªDWEDWF. >=65 Years A0B–Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBcmRNA-1273-P301 mRNA-1273-P301-US371-2059US3712059US371USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVªDWFDVªHrAÊÌDVÈHriG DVÈHriG DWFHs“DWFHs“...DW]DVªDWEDWF.DVªDWEDWF. >=65 Years A0B–Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBcBcmômRNA-1273-P301 mRNA-1273-P301-US371-2129US3712129US371USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW]DV¦Hr<ž”DVÂHrajXDVÂHrajXDW:Hrÿ¸˜DW]Hs-ŸìDW]Hs-Ÿì.DW]DV¦DW9DW:.DV¦DW9DW:. >=18 and <65 Years and Not at RiskABœNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BgmRNA-1273-P301 mRNA-1273-P301-US371-2129US3712129US371USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW]DV¦Hr<ž”DVÂHrajXDVÂHrajXDW:Hrÿ¸˜DW]Hs-ŸìDW]Hs-Ÿì.DW]DV¦DW9DW:.DV¦DW9DW:. >=18 and <65 Years and Not at RiskABœNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BgBgmômRNA-1273-P301 mRNA-1273-P301-US371-2129US3712129US371USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW]DV¦Hr<ž”DVÂHrajXDVÂHrajXDW:Hrÿ¸˜DW]Hs-ŸìDW]Hs-Ÿì.DW]DV¦DW9DW:.DV¦DW9DW:. >=18 and <65 Years and Not at RiskABœNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BgmôBgÛèmRNA-1273-P301 mRNA-1273-P301-US371-2142US3712142US371USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DWGDV¥Hr;ðDVÁHr_ìPDVÁHr_ìPDWGHs·ˆDWGHs·ˆ...DW]DV¥DWFDWG.DV¥DWFDWG. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BxmRNA-1273-P301 mRNA-1273-P301-US371-2142US3712142US371USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DWGDV¥Hr;ðDVÁHr_ìPDVÁHr_ìPDWGHs·ˆDWGHs·ˆ...DW]DV¥DWFDWG.DV¥DWFDWG. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BxBxmômRNA-1273-P301 mRNA-1273-P301-US371-2142US3712142US371USAB!YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DWGDV¥Hr;ðDVÁHr_ìPDVÁHr_ìPDWGHs·ˆDWGHs·ˆ...DW]DV¥DWFDWG.DV¥DWFDWG. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BxmôBxÛèmRNA-1273-P301 mRNA-1273-P301-US371-2150US3712150US371USAB=YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW]DV¦Hr=18 and <65 Years and at Risk A BœNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBimRNA-1273-P301 mRNA-1273-P301-US371-2150US3712150US371USAB=YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DW]DV¦Hr=18 and <65 Years and at Risk A BœNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBiBimômRNA-1273-P301 mRNA-1273-P301-US371-2159US3712159US371USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DW/DV¤Hr9È|DVÀHr^®øDVÀHr^®øDWHrÅ–DW/Hrñ=DW/Hrñ=.DW]DV¤DW DW.DV¤DW DW. >=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BmRNA-1273-P301 mRNA-1273-P301-US371-2159US3712159US371USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DW/DV¤Hr9È|DVÀHr^®øDVÀHr^®øDWHrÅ–DW/Hrñ=DW/Hrñ=.DW]DV¤DW DW.DV¤DW DW. >=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BBmómRNA-1273-P301 mRNA-1273-P301-US371-2159US3712159US371USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DW/DV¤Hr9È|DVÀHr^®øDVÀHr^®øDWHrÅ–DW/Hrñ=DW/Hrñ=.DW]DV¤DW DW.DV¤DW DW. >=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BmóBÛçmRNA-1273-P301 mRNA-1273-P301-US371-2159US3712159US371USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¤DW/DV¤Hr9È|DVÀHr^®øDVÀHr^®øDWHrÅ–DW/Hrñ=DW/Hrñ=.DW]DV¤DW DW.DV¤DW DW. >=18 and <65 Years and Not at RiskABžMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BÛçBIÚmRNA-1273-P301 mRNA-1273-P301-US371-2247US3712247US371USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVÃDVßDVÃHrbËŒDVßHr‡DVßHr‡.......DW]DVÃDW>DW?.DVÃDW>DW?. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB6mRNA-1273-P301 mRNA-1273-P301-US371-2247US3712247US371USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVÃDVßDVÃHrbËŒDVßHr‡DVßHr‡.......DW]DVÃDW>DW?.DVÃDW>DW?. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB6B6mômRNA-1273-P301 mRNA-1273-P301-US371-2281US3712281US371USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVÃDVâDVÃHrcpDVâHr‹otDVâHr‹ot.......DW]DVÃDW/DW0.DVÃDW/DW0. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BMmRNA-1273-P301 mRNA-1273-P301-US371-2281US3712281US371USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVÃDVâDVÃHrcpDVâHr‹otDVâHr‹ot.......DW]DVÃDW/DW0.DVÃDW/DW0. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BMBMmômRNA-1273-P301 mRNA-1273-P301-US371-2281US3712281US371USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVÃDVâDVÃHrcpDVâHr‹otDVâHr‹ot.......DW]DVÃDW/DW0.DVÃDW/DW0. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BMmôBMÛèmRNA-1273-P301 mRNA-1273-P301-US371-2304US3712304US371USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW]DVÃHrbä DVßHr‡x$DVßHr‡x$DWAHsÂ”DW]Hs-XDW]Hs-X.DW]DVÃDW@DWA.DVÃDW@DWA. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BTmRNA-1273-P301 mRNA-1273-P301-US371-2304US3712304US371USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW]DVÃHrbä DVßHr‡x$DVßHr‡x$DWAHsÂ”DW]Hs-XDW]Hs-X.DW]DVÃDW@DWA.DVÃDW@DWA. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BTBTmômRNA-1273-P301 mRNA-1273-P301-US371-2304US3712304US371USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW]DVÃHrbä DVßHr‡x$DVßHr‡x$DWAHsÂ”DW]Hs-XDW]Hs-X.DW]DVÃDW@DWA.DVÃDW@DWA. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BTmôBTÛèmRNA-1273-P301 mRNA-1273-P301-US371-2308US3712308US371USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW]DVÃHrc äDVâHr‹xÔDVâHr‹xÔDW:Hrÿ‹ DW]Hs-ê°DW]Hs-ê°.DW]DVÃDW9DW:.DVÃDW9DW:. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BLmRNA-1273-P301 mRNA-1273-P301-US371-2308US3712308US371USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW]DVÃHrc äDVâHr‹xÔDVâHr‹xÔDW:Hrÿ‹ DW]Hs-ê°DW]Hs-ê°.DW]DVÃDW9DW:.DVÃDW9DW:. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BLBLmômRNA-1273-P301 mRNA-1273-P301-US371-2308US3712308US371USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW]DVÃHrc äDVâHr‹xÔDVâHr‹xÔDW:Hrÿ‹ DW]Hs-ê°DW]Hs-ê°.DW]DVÃDW9DW:.DVÃDW9DW:. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BLmôBLÛèmRNA-1273-P301 mRNA-1273-P301-US371-2308US3712308US371USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÃDW]DVÃHrc äDVâHr‹xÔDVâHr‹xÔDW:Hrÿ‹ DW]Hs-ê°DW]Hs-ê°.DW]DVÃDW9DW:.DVÃDW9DW:. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BLÛèBLIÜmRNA-1273-P301 mRNA-1273-P301-US372-2006US3722006US372USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW1DVoHqóÅ DVŽHrº DVŽHrº DWHrÎá(DW1Hróø DW1Hróø .DW]DVoDWDW.DVoDWDW. Severe Obesity >=18 and <65 Years and at Risk A BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BlmRNA-1273-P301 mRNA-1273-P301-US372-2046US3722046US372USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW7DVrHq÷Ö°DVŽHr»LDVŽHr»LDWHrÖ—LDW7Hrû~ôDW7Hrû~ô.DW]DVrDWDW.DVrDWDW. Diabetes >=18 and <65 Years and at Risk A BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BŽmRNA-1273-P301 mRNA-1273-P301-US372-2046US3722046US372USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW7DVrHq÷Ö°DVŽHr»LDVŽHr»LDWHrÖ—LDW7Hrû~ôDW7Hrû~ô.DW]DVrDWDW.DVrDWDW. Diabetes >=18 and <65 Years and at Risk A BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BŽBŽmðmRNA-1273-P301 mRNA-1273-P301-US372-2046US3722046US372USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW7DVrHq÷Ö°DVŽHr»LDVŽHr»LDWHrÖ—LDW7Hrû~ôDW7Hrû~ô.DW]DVrDWDW.DVrDWDW. Diabetes >=18 and <65 Years and at Risk A BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BŽmðBŽÛèmRNA-1273-P301 mRNA-1273-P301-US372-2075US3722075US372USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWEDVsHqù!ÜDVŒHrDVŒHrDW)Hré|DWEHsY¬DWEHsY¬.DW]DVsDW(DW).DVsDW(DW). >=18 and <65 Years and Not at RiskABÒNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB›mRNA-1273-P301 mRNA-1273-P301-US372-2075US3722075US372USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWEDVsHqù!ÜDVŒHrDVŒHrDW)Hré|DWEHsY¬DWEHsY¬.DW]DVsDW(DW).DVsDW(DW). >=18 and <65 Years and Not at RiskABÒNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB›B›mðmRNA-1273-P301 mRNA-1273-P301-US372-2085US3722085US372USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDWADVsHqùhàDVHr)dDVHr)dDW"Hrßñ¬DWAHs¶ DWAHs¶ .DW]DVsDW!DW".DVsDW!DW". >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B’mRNA-1273-P301 mRNA-1273-P301-US372-2095US3722095US372USAB=YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW6DVtHqú|DVHrSÀDVHrSÀDWHrÕRìDW6HrúC¸DW6HrúC¸.DW]DVtDWDW.DVtDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BxmRNA-1273-P301 mRNA-1273-P301-US372-2095US3722095US372USAB=YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW6DVtHqú|DVHrSÀDVHrSÀDWHrÕRìDW6HrúC¸DW6HrúC¸.DW]DVtDWDW.DVtDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BxBxmômRNA-1273-P301 mRNA-1273-P301-US372-2095US3722095US372USAB=YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW6DVtHqú|DVHrSÀDVHrSÀDWHrÕRìDW6HrúC¸DW6HrúC¸.DW]DVtDWDW.DVtDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÎNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BxmôBxÛèmRNA-1273-P301 mRNA-1273-P301-US372-2099US3722099US372USAB:YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWEDVtHqúlDVHrDVHrDW)Hré4DWEHs ïøDWEHs ïø.DW]DVtDW(DW).DVtDW(DW). Significant Cardiac Disease >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB˜mRNA-1273-P301 mRNA-1273-P301-US372-2099US3722099US372USAB:YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWEDVtHqúlDVHrDVHrDW)Hré4DWEHs ïøDWEHs ïø.DW]DVtDW(DW).DVtDW(DW). Significant Cardiac Disease >=18 and <65 Years and at Risk A BÏNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB˜B˜mðmRNA-1273-P301 mRNA-1273-P301-US372-2107US3722107US372USAB=YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW/DVtHqú²,DVHrˆ@DVHrˆ@DWHrÎ¿àDW/HrñÈDW/HrñÈ.DW]DVtDWDW.DVtDWDW. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBxmRNA-1273-P301 mRNA-1273-P301-US372-2107US3722107US372USAB=YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW/DVtHqú²,DVHrˆ@DVHrˆ@DWHrÎ¿àDW/HrñÈDW/HrñÈ.DW]DVtDWDW.DVtDWDW. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBxBxmômRNA-1273-P301 mRNA-1273-P301-US372-2121US3722121US372USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW@DVuHqûãTDV–Hr'T¨DV–Hr'T¨DW$Hrâ|DW@HsqŒDW@HsqŒ.DW]DVuDW#DW$.DVuDW#DW$. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B’mRNA-1273-P301 mRNA-1273-P301-US372-2121US3722121US372USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW@DVuHqûãTDV–Hr'T¨DV–Hr'T¨DW$Hrâ|DW@HsqŒDW@HsqŒ.DW]DVuDW#DW$.DVuDW#DW$. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B’B’mðmRNA-1273-P301 mRNA-1273-P301-US372-2121US3722121US372USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW@DVuHqûãTDV–Hr'T¨DV–Hr'T¨DW$Hrâ|DW@HsqŒDW@HsqŒ.DW]DVuDW#DW$.DVuDW#DW$. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B’mðB’ÛèmRNA-1273-P301 mRNA-1273-P301-US372-2125US3722125US372USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVuDVDVuHqûöÈDVHr²¬DVHr²¬.......DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB|mRNA-1273-P301 mRNA-1273-P301-US372-2125US3722125US372USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVuDVDVuHqûöÈDVHr²¬DVHr²¬.......DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÎNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB|B|mômRNA-1273-P301 mRNA-1273-P301-US372-2150US3722150US372USAB@YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW6DVvHqýRÔDV’Hr"DV’Hr"DWHrÕgPDW6HrúT˜DW6HrúT˜.DW]DVvDWDW.DVvDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B…mRNA-1273-P301 mRNA-1273-P301-US372-2150US3722150US372USAB@YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW6DVvHqýRÔDV’Hr"DV’Hr"DWHrÕgPDW6HrúT˜DW6HrúT˜.DW]DVvDWDW.DVvDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B…B…mðmRNA-1273-P301 mRNA-1273-P301-US372-2150US3722150US372USAB@YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW6DVvHqýRÔDV’Hr"DV’Hr"DWHrÕgPDW6HrúT˜DW6HrúT˜.DW]DVvDWDW.DVvDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B…mðB…ÛèmRNA-1273-P301 mRNA-1273-P301-US372-2150US3722150US372USAB@YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW6DVvHqýRÔDV’Hr"DV’Hr"DWHrÕgPDW6HrúT˜DW6HrúT˜.DW]DVvDWDW.DVvDWDW. Significant Cardiac Disease >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B…ÛèB…IØmRNA-1273-P301 mRNA-1273-P301-US372-2154US3722154US372USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW0DVvHqýo¨DV–Hr'FÔDV–Hr'FÔDWHrÍu,DW0HròH¬DW0HròH¬.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB}mRNA-1273-P301 mRNA-1273-P301-US372-2154US3722154US372USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW0DVvHqýo¨DV–Hr'FÔDV–Hr'FÔDWHrÍu,DW0HròH¬DW0HròH¬.DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB}B}mômRNA-1273-P301 mRNA-1273-P301-US372-2196US3722196US372USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWODVzHrñ0DV’Hr"I@DV’Hr"I@DW+Hrì"$DWOHs^¸DWOHs^¸.DW]DVzDW*DW+.DVzDW*DW+. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB“mRNA-1273-P301 mRNA-1273-P301-US372-2196US3722196US372USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDWODVzHrñ0DV’Hr"I@DV’Hr"I@DW+Hrì"$DWOHs^¸DWOHs^¸.DW]DVzDW*DW+.DVzDW*DW+. >=18 and <65 Years and Not at RiskABÌNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB“B“mðmRNA-1273-P301 mRNA-1273-P301-US372-2211US3722211US372USAB9YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DW@DV{HrÒ¨DVœHr/)DDVœHr/)DDW#HrájDW@Hs°˜DW@Hs°˜.DW]DV{DW"DW#.DV{DW"DW#. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BŒmRNA-1273-P301 mRNA-1273-P301-US372-2213US3722213US372USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWGDV{Hrø(DVžHr2DVžHr2DW*Hrê½0DWGHsì€DWGHsì€.DW]DV{DW)DW*.DV{DW)DW*. >=18 and <65 Years and Not at RiskABÀNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB’mRNA-1273-P301 mRNA-1273-P301-US372-2213US3722213US372USAB"YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWGDV{Hrø(DVžHr2DVžHr2DW*Hrê½0DWGHsì€DWGHsì€.DW]DV{DW)DW*.DV{DW)DW*. >=18 and <65 Years and Not at RiskABÀNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB’B’mðmRNA-1273-P301 mRNA-1273-P301-US372-2228US3722228US372USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWDDV|HrPDV—Hr(ž¨DV—Hr(ž¨DW(HrçÕDWDHs´DDWDHs´D.DW]DV|DW'DW(.DV|DW'DW(. >=65 Years A0BÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US372-2228US3722228US372USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWDDV|HrPDV—Hr(ž¨DV—Hr(ž¨DW(HrçÕDWDHs´DDWDHs´D.DW]DV|DW'DW(.DV|DW'DW(. >=65 Years A0BÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmðmRNA-1273-P301 mRNA-1273-P301-US372-2228US3722228US372USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWDDV|HrPDV—Hr(ž¨DV—Hr(ž¨DW(HrçÕDWDHs´DDWDHs´D.DW]DV|DW'DW(.DV|DW'DW(. >=65 Years A0BÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US372-2255US3722255US372USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWDDV}HrYˆDVšHr,Œ˜DVšHr,Œ˜DW(Hrè%¬DWDHs hDWDHs h.DW]DV}DW'DW(.DV}DW'DW(. >=18 and <65 Years and Not at RiskABÄNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmRNA-1273-P301 mRNA-1273-P301-US372-2275US3722275US372USAB-YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DW?DV~Hr«€DVšHr,}˜DVšHr,}˜DW#Hrá/DW?Hs" DW?Hs" .DW]DV~DW"DW#.DV~DW"DW#. Significant Cardiac DiseaseSevere ObesityDiabetes >=18 and <65 Years and at Risk A BÄMinority .At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBrmRNA-1273-P301 mRNA-1273-P301-US372-2275US3722275US372USAB-YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MUNKNOWN HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV~DW?DV~Hr«€DVšHr,}˜DVšHr,}˜DW#Hrá/DW?Hs" DW?Hs" .DW]DV~DW"DW#.DV~DW"DW#. Significant Cardiac DiseaseSevere ObesityDiabetes >=18 and <65 Years and at Risk A BÄMinority .At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBrBrmômRNA-1273-P301 mRNA-1273-P301-US372-2316US3722316US372USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWMDV‚Hr 2lDVžHr20DVžHr20DW1HróÀØDWMHs¥ìDWMHs¥ì.DW]DV‚DW0DW1.DV‚DW0DW1. >=18 and <65 Years and Not at RiskABÀNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‘mRNA-1273-P301 mRNA-1273-P301-US372-2316US3722316US372USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWMDV‚Hr 2lDVžHr20DVžHr20DW1HróÀØDWMHs¥ìDWMHs¥ì.DW]DV‚DW0DW1.DV‚DW0DW1. >=18 and <65 Years and Not at RiskABÀNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‘B‘mðmRNA-1273-P301 mRNA-1273-P301-US372-2316US3722316US372USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWMDV‚Hr 2lDVžHr20DVžHr20DW1HróÀØDWMHs¥ìDWMHs¥ì.DW]DV‚DW0DW1.DV‚DW0DW1. >=18 and <65 Years and Not at RiskABÀNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‘mðB‘ÛèmRNA-1273-P301 mRNA-1273-P301-US372-2347US3722347US372USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWDDV„HrÕ¨DV Hr4{8DV Hr4{8DW$Hrâã0DWDHs ÜDWDHs Ü.DW]DV„DW#DW$.DV„DW#DW$. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‚mRNA-1273-P301 mRNA-1273-P301-US372-2375US3722375US372USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW@DVˆHrÚDV¥Hr;tDV¥Hr;tDW$Hrâ•œDW@HsŸ¸DW@HsŸ¸.DW]DVˆDW#DW$.DVˆDW#DW$. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BLmRNA-1273-P301 mRNA-1273-P301-US372-2375US3722375US372USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW@DVˆHrÚDV¥Hr;tDV¥Hr;tDW$Hrâ•œDW@HsŸ¸DW@HsŸ¸.DW]DVˆDW#DW$.DVˆDW#DW$. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BLBLmômRNA-1273-P301 mRNA-1273-P301-US372-2375US3722375US372USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW@DVˆHrÚDV¥Hr;tDV¥Hr;tDW$Hrâ•œDW@HsŸ¸DW@HsŸ¸.DW]DVˆDW#DW$.DVˆDW#DW$. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BLmôBLÛèmRNA-1273-P301 mRNA-1273-P301-US372-2382US3722382US372USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW*DVˆHrö DV¤Hr:DV¤Hr:DWHrÅá|DW*Hrê~ØDW*Hrê~Ø.DW]DVˆDW DW.DVˆDW DW. >=65 Years A0BºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B3mRNA-1273-P301 mRNA-1273-P301-US372-2382US3722382US372USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW*DVˆHrö DV¤Hr:DV¤Hr:DWHrÅá|DW*Hrê~ØDW*Hrê~Ø.DW]DVˆDW DW.DVˆDW DW. >=65 Years A0BºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B3B3mômRNA-1273-P301 mRNA-1273-P301-US372-2382US3722382US372USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW*DVˆHrö DV¤Hr:DV¤Hr:DWHrÅá|DW*Hrê~ØDW*Hrê~Ø.DW]DVˆDW DW.DVˆDW DW. >=65 Years A0BºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B3môB3ÛæmRNA-1273-P301 mRNA-1273-P301-US373-2075US3732075US373USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW:DV}Hr¹ÜDV˜Hr*J DV˜Hr*J DWHrÚÝÔDW:Hrÿ‘tDW:Hrÿ‘t.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBTmRNA-1273-P301 mRNA-1273-P301-US373-2075US3732075US373USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW:DV}Hr¹ÜDV˜Hr*J DV˜Hr*J DWHrÚÝÔDW:Hrÿ‘tDW:Hrÿ‘t.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskABÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBTBTmômRNA-1273-P301 mRNA-1273-P301-US373-2174US3732174US373USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰Hr-àDV¥Hr;0ôDV¥Hr;0ôDW)Hré&DWEHs^ÔDWEHs^Ô.DW]DV‰DW(DW).DV‰DW(DW). >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BimRNA-1273-P301 mRNA-1273-P301-US373-2174US3732174US373USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰Hr-àDV¥Hr;0ôDV¥Hr;0ôDW)Hré&DWEHs^ÔDWEHs^Ô.DW]DV‰DW(DW).DV‰DW(DW). >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BiBimômRNA-1273-P301 mRNA-1273-P301-US373-2174US3732174US373USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰Hr-àDV¥Hr;0ôDV¥Hr;0ôDW)Hré&DWEHs^ÔDWEHs^Ô.DW]DV‰DW(DW).DV‰DW(DW). >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BimôBiÛèmRNA-1273-P301 mRNA-1273-P301-US373-2174US3732174US373USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWEDV‰Hr-àDV¥Hr;0ôDV¥Hr;0ôDW)Hré&DWEHs^ÔDWEHs^Ô.DW]DV‰DW(DW).DV‰DW(DW). >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BiÛèBiIÜmRNA-1273-P301 mRNA-1273-P301-US373-2202US3732202US373USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŠDV§DVŠHr¼ŒDV§Hr>¤DV§Hr>¤.......DW]DVŠDW DWDWDVŠDW DWDW >=18 and <65 Years and Not at RiskABiNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BNmRNA-1273-P301 mRNA-1273-P301-US373-2280US3732280US373USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWLDV’Hr"øDV²HrLƒDV²HrLƒDW0Hròœ”DWLHs0DWLHs0.DW]DV’DW/DW0.DV’DW/DW0. >=18 and <65 Years and Not at RiskAB¬Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BlmRNA-1273-P301 mRNA-1273-P301-US373-2280US3732280US373USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWLDV’Hr"øDV²HrLƒDV²HrLƒDW0Hròœ”DWLHs0DWLHs0.DW]DV’DW/DW0.DV’DW/DW0. >=18 and <65 Years and Not at RiskAB¬Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BlBlmômRNA-1273-P301 mRNA-1273-P301-US373-2280US3732280US373USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWLDV’Hr"øDV²HrLƒDV²HrLƒDW0Hròœ”DWLHs0DWLHs0.DW]DV’DW/DW0.DV’DW/DW0. >=18 and <65 Years and Not at RiskAB¬Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BlmôBlÛèmRNA-1273-P301 mRNA-1273-P301-US373-2280US3732280US373USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWLDV’Hr"øDV²HrLƒDV²HrLƒDW0Hròœ”DWLHs0DWLHs0.DW]DV’DW/DW0.DV’DW/DW0. >=18 and <65 Years and Not at RiskAB¬Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BlÛèBlIÜmRNA-1273-P301 mRNA-1273-P301-US373-2371US3732371US373USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DW]DV¥Hr;'DVÁHr`%€DVÁHr`%€DW@HsØDW]Hs-÷”DW]Hs-÷”.DW]DV¥DW?DW@.DV¥DW?DW@. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BcmRNA-1273-P301 mRNA-1273-P301-US373-2371US3732371US373USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DW]DV¥Hr;'DVÁHr`%€DVÁHr`%€DW@HsØDW]Hs-÷”DW]Hs-÷”.DW]DV¥DW?DW@.DV¥DW?DW@. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BcBcmômRNA-1273-P301 mRNA-1273-P301-US373-2371US3732371US373USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¥DW]DV¥Hr;'DVÁHr`%€DVÁHr`%€DW@HsØDW]Hs-÷”DW]Hs-÷”.DW]DV¥DW?DW@.DV¥DW?DW@. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BcmôBcÛèmRNA-1273-P301 mRNA-1273-P301-US373-2399US3732399US373USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV¿DVÛDV¿Hr]´äDVÛHr‚™€DVÛHr‚™€.......DW]DV¿DW DW .DV¿DW DW . Liver Disease >=18 and <65 Years and at Risk A BƒNon-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBAmRNA-1273-P301 mRNA-1273-P301-US373-2399US3732399US373USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV¿DVÛDV¿Hr]´äDVÛHr‚™€DVÛHr‚™€.......DW]DV¿DW DW .DV¿DW DW . Liver Disease >=18 and <65 Years and at Risk A BƒNon-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBABAmômRNA-1273-P301 mRNA-1273-P301-US373-2401US3732401US373USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWRDVÁHr`QÌDVßHr‡×DVßHr‡×DW7HrûáÜDWRHsqìDWRHsqì.DW]DVÁDW6DW7.DVÁDW6DW7. Severe Obesity >=18 and <65 Years and at Risk A BMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBDmRNA-1273-P301 mRNA-1273-P301-US373-2401US3732401US373USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWRDVÁHr`QÌDVßHr‡×DVßHr‡×DW7HrûáÜDWRHsqìDWRHsqì.DW]DVÁDW6DW7.DVÁDW6DW7. Severe Obesity >=18 and <65 Years and at Risk A BMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBDBDmômRNA-1273-P301 mRNA-1273-P301-US374-2022US3742022US374USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW8DV‚Hr OôDVžHr2DVžHr2DWHr×Ü$DW8HrüÅèDW8HrüÅè.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBimRNA-1273-P301 mRNA-1273-P301-US374-2022US3742022US374USAB&YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW8DV‚Hr OôDVžHr2DVžHr2DWHr×Ü$DW8HrüÅèDW8HrüÅè.DW]DV‚DWDW.DV‚DWDW. Severe Obesity >=18 and <65 Years and at Risk A BÀNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBiBimômRNA-1273-P301 mRNA-1273-P301-US374-2041US3742041US374USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWGDV…Hr<DV Hr4‹dDV Hr4‹dDW!HrÞ‹DWGHs«”DWGHs«”.DW]DV…DW DW!.DV…DW DW!. >=18 and <65 Years and Not at RiskAB¾Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BnmRNA-1273-P301 mRNA-1273-P301-US374-2041US3742041US374USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWGDV…Hr<DV Hr4‹dDV Hr4‹dDW!HrÞ‹DWGHs«”DWGHs«”.DW]DV…DW DW!.DV…DW DW!. >=18 and <65 Years and Not at RiskAB¾Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BnBnmômRNA-1273-P301 mRNA-1273-P301-US374-2041US3742041US374USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWGDV…Hr<DV Hr4‹dDV Hr4‹dDW!HrÞ‹DWGHs«”DWGHs«”.DW]DV…DW DW!.DV…DW DW!. >=18 and <65 Years and Not at RiskAB¾Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BnmôBnÛèmRNA-1273-P301 mRNA-1273-P301-US374-2047US3742047US374USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV…DWNDV…Hr-DV¡Hr5úlDV¡Hr5úlDW2Hrõ8DWNHsÎ¤DWNHsÎ¤.DW]DV…DW1DW2.DV…DW1DW2.Chronic Lung Disease >=18 and <65 Years and at Risk A B½Minority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmRNA-1273-P301 mRNA-1273-P301-US374-2070US3742070US374USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŠDV¦DVŠHrÐðDV¦Hr<½DV¦Hr<½.......DW]DVŠDWDW.DVŠDWDW. >=18 and <65 Years and Not at RiskAB¸Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBqmRNA-1273-P301 mRNA-1273-P301-US374-2070US3742070US374USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŠDV¦DVŠHrÐðDV¦Hr<½DV¦Hr<½.......DW]DVŠDWDW.DVŠDWDW. >=18 and <65 Years and Not at RiskAB¸Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBqBqmômRNA-1273-P301 mRNA-1273-P301-US374-2120US3742120US374USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHr0DVªHrAýlDVªHrAýlDW!HrÞ£°DW@HsldDW@Hsld.DW]DVŽDW DW!.DVŽDW DW!. >=18 and <65 Years and Not at RiskAB´Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BwmRNA-1273-P301 mRNA-1273-P301-US374-2120US3742120US374USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHr0DVªHrAýlDVªHrAýlDW!HrÞ£°DW@HsldDW@Hsld.DW]DVŽDW DW!.DVŽDW DW!. >=18 and <65 Years and Not at RiskAB´Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BwBwmômRNA-1273-P301 mRNA-1273-P301-US374-2120US3742120US374USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHr0DVªHrAýlDVªHrAýlDW!HrÞ£°DW@HsldDW@Hsld.DW]DVŽDW DW!.DVŽDW DW!. >=18 and <65 Years and Not at RiskAB´Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BwmôBwÛèmRNA-1273-P301 mRNA-1273-P301-US374-2120US3742120US374USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FNOT REPORTED HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHr0DVªHrAýlDVªHrAýlDW!HrÞ£°DW@HsldDW@Hsld.DW]DVŽDW DW!.DVŽDW DW!. >=18 and <65 Years and Not at RiskAB´Minority .Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BwÛèBwIÜmRNA-1273-P301 mRNA-1273-P301-US374-2123US3742123US374USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW@DV‘Hr îœDV´HrO pDV´HrO pDWHrÙb$DW@HsxÐDW@HsxÐ.DW]DV‘DWDW.DV‘DWDW. >=18 and <65 Years and Not at RiskABªMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B0mRNA-1273-P301 mRNA-1273-P301-US374-2123US3742123US374USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW@DV‘Hr îœDV´HrO pDV´HrO pDWHrÙb$DW@HsxÐDW@HsxÐ.DW]DV‘DWDW.DV‘DWDW. >=18 and <65 Years and Not at RiskABªMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B0B0mômRNA-1273-P301 mRNA-1273-P301-US374-2123US3742123US374USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW@DV‘Hr îœDV´HrO pDV´HrO pDWHrÙb$DW@HsxÐDW@HsxÐ.DW]DV‘DWDW.DV‘DWDW. >=18 and <65 Years and Not at RiskABªMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B0môB0ÛæmRNA-1273-P301 mRNA-1273-P301-US374-2123US3742123US374USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW@DV‘Hr îœDV´HrO pDV´HrO pDWHrÙb$DW@HsxÐDW@HsxÐ.DW]DV‘DWDW.DV‘DWDW. >=18 and <65 Years and Not at RiskABªMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B0ÛæB0IÚmRNA-1273-P301 mRNA-1273-P301-US374-2160US3742160US374USABWYEARS>=65 Years A0>=65 Years A >=75 Years A0>=85 Years A@ .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŒDW*DVŒHrfDV¨Hr?5(DV¨Hr?5(DWHrÈ=DW*Hrê~œDW*Hrê~œ.DW]DVŒDWDW.DVŒDWDW. >=65 Years A0B¶Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BWmRNA-1273-P301 mRNA-1273-P301-US374-2160US3742160US374USABWYEARS>=65 Years A0>=65 Years A >=75 Years A0>=85 Years A@ .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŒDW*DVŒHrfDV¨Hr?5(DV¨Hr?5(DWHrÈ=DW*Hrê~œDW*Hrê~œ.DW]DVŒDWDW.DVŒDWDW. >=65 Years A0B¶Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BWBWmômRNA-1273-P301 mRNA-1273-P301-US374-2160US3742160US374USABWYEARS>=65 Years A0>=65 Years A >=75 Years A0>=85 Years A@ .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŒDW*DVŒHrfDV¨Hr?5(DV¨Hr?5(DWHrÈ=DW*Hrê~œDW*Hrê~œ.DW]DVŒDWDW.DVŒDWDW. >=65 Years A0B¶Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BWmôBWÛèmRNA-1273-P301 mRNA-1273-P301-US374-2357US3742357US374USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŸDV»DVŸHr3`TDV»HrX=4DV»HrX=4.......DW]DVŸDWDW.DVŸDWDW. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBfmRNA-1273-P301 mRNA-1273-P301-US374-2357US3742357US374USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŸDV»DVŸHr3`TDV»HrX=4DV»HrX=4.......DW]DVŸDWDW.DVŸDWDW. >=18 and <65 Years and Not at RiskAB£Minority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBfBfmômRNA-1273-P301 mRNA-1273-P301-US374-2491US3742491US374USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DW8DV´HrNì¬DVÐHrsÄÜDVÐHrsÄÜDWHrØ€DW8HrüøÄDW8HrüøÄ.DW]DV´DWDW.DV´DWDW. >=18 and <65 Years and Not at RiskABŽNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BKmRNA-1273-P301 mRNA-1273-P301-US374-2491US3742491US374USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DW8DV´HrNì¬DVÐHrsÄÜDVÐHrsÄÜDWHrØ€DW8HrüøÄDW8HrüøÄ.DW]DV´DWDW.DV´DWDW. >=18 and <65 Years and Not at RiskABŽNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BKBKmômRNA-1273-P301 mRNA-1273-P301-US374-2491US3742491US374USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DW8DV´HrNì¬DVÐHrsÄÜDVÐHrsÄÜDWHrØ€DW8HrüøÄDW8HrüøÄ.DW]DV´DWDW.DV´DWDW. >=18 and <65 Years and Not at RiskABŽNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BKmôBKÛèmRNA-1273-P301 mRNA-1273-P301-US375-2069US3752069US375USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV|DV˜DV|HrDV˜Hr)æŒDV˜Hr)æŒ.......DW]DV|DW@..DV|DW@.. Severe Obesity >=18 and <65 Years and at Risk A B©Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BOmRNA-1273-P301 mRNA-1273-P301-US375-2161US3752161US375USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW?DV‚Hr :dDVžHr1çìDVžHr1çìDWHrÕ_ÐDW?Hs/üDW?Hs/ü.DW]DV‚DWDW.DV‚DWDW. >=65 Years A0BÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBEmRNA-1273-P301 mRNA-1273-P301-US375-2161US3752161US375USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW?DV‚Hr :dDVžHr1çìDVžHr1çìDWHrÕ_ÐDW?Hs/üDW?Hs/ü.DW]DV‚DWDW.DV‚DWDW. >=65 Years A0BÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBEBEmômRNA-1273-P301 mRNA-1273-P301-US375-2162US3752162US375USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW?DV‚Hr =èDVžHr1éDVžHr1éDWHrÕ^hDW?Hs.XDW?Hs.X.DW]DV‚DWDW.DV‚DWDW.Chronic Lung Disease >=65 Years A0BÀNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B;mRNA-1273-P301 mRNA-1273-P301-US375-2162US3752162US375USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW?DV‚Hr =èDVžHr1éDVžHr1éDWHrÕ^hDW?Hs.XDW?Hs.X.DW]DV‚DWDW.DV‚DWDW.Chronic Lung Disease >=65 Years A0BÀNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B;B;mômRNA-1273-P301 mRNA-1273-P301-US375-2162US3752162US375USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW?DV‚Hr =èDVžHr1éDVžHr1éDWHrÕ^hDW?Hs.XDW?Hs.X.DW]DV‚DWDW.DV‚DWDW.Chronic Lung Disease >=65 Years A0BÀNon-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B;môB;ÛæmRNA-1273-P301 mRNA-1273-P301-US375-2208US3752208US375USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW0DV„HrÑ4DV Hr4‘ôDV Hr4‘ôDWHrÑN¸DW0HròH4DW0HròH4.DW]DV„DWDW.DV„DWDW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B_mRNA-1273-P301 mRNA-1273-P301-US375-2208US3752208US375USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW0DV„HrÑ4DV Hr4‘ôDV Hr4‘ôDWHrÑN¸DW0HròH4DW0HròH4.DW]DV„DWDW.DV„DWDW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B_B_mômRNA-1273-P301 mRNA-1273-P301-US375-2208US3752208US375USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW0DV„HrÑ4DV Hr4‘ôDV Hr4‘ôDWHrÑN¸DW0HròH4DW0HròH4.DW]DV„DWDW.DV„DWDW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B_môB_ÛèmRNA-1273-P301 mRNA-1273-P301-US375-2208US3752208US375USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DW0DV„HrÑ4DV Hr4‘ôDV Hr4‘ôDWHrÑN¸DW0HròH4DW0HròH4.DW]DV„DWDW.DV„DWDW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B_ÛèB_IÜmRNA-1273-P301 mRNA-1273-P301-US375-2213US3752213US375USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWGDV„Hrê„DV Hr4˜„DV Hr4˜„DW*Hrê”,DWGHsÔ\DWGHsÔ\.DW]DV„DW)DW*.DV„DW)DW*. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US375-2213US3752213US375USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWGDV„Hrê„DV Hr4˜„DV Hr4˜„DW*Hrê”,DWGHsÔ\DWGHsÔ\.DW]DV„DW)DW*.DV„DW)DW*. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmðmRNA-1273-P301 mRNA-1273-P301-US375-2213US3752213US375USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWGDV„Hrê„DV Hr4˜„DV Hr4˜„DW*Hrê”,DWGHsÔ\DWGHsÔ\.DW]DV„DW)DW*.DV„DW)DW*. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US375-2225US3752225US375USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWLDV‡Hr½øDV¦Hr<“ÌDV¦Hr<“ÌDW0Hròq8DWLHsRDWLHsR.DW]DV‡DW/DW0.DV‡DW/DW0. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B…mRNA-1273-P301 mRNA-1273-P301-US375-2225US3752225US375USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWLDV‡Hr½øDV¦Hr<“ÌDV¦Hr<“ÌDW0Hròq8DWLHsRDWLHsR.DW]DV‡DW/DW0.DV‡DW/DW0. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B…B…mðmRNA-1273-P301 mRNA-1273-P301-US375-2225US3752225US375USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWLDV‡Hr½øDV¦Hr<“ÌDV¦Hr<“ÌDW0Hròq8DWLHsRDWLHsR.DW]DV‡DW/DW0.DV‡DW/DW0. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B…mðB…ÛèmRNA-1273-P301 mRNA-1273-P301-US375-2225US3752225US375USAB0YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DWLDV‡Hr½øDV¦Hr<“ÌDV¦Hr<“ÌDW0Hròq8DWLHsRDWLHsR.DW]DV‡DW/DW0.DV‡DW/DW0. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B…ÛèB…IØmRNA-1273-P301 mRNA-1273-P301-US375-2250US3752250US375USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW=DVˆHr)¸DV¤Hr9ÑdDV¤Hr9ÑdDWHrÌ[°DW=Hs™hDW=Hs™h.DW]DVˆDWDW.DVˆDWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BLmRNA-1273-P301 mRNA-1273-P301-US375-2250US3752250US375USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW=DVˆHr)¸DV¤Hr9ÑdDV¤Hr9ÑdDWHrÌ[°DW=Hs™hDW=Hs™h.DW]DVˆDWDW.DVˆDWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BLBLmômRNA-1273-P301 mRNA-1273-P301-US375-2250US3752250US375USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW=DVˆHr)¸DV¤Hr9ÑdDV¤Hr9ÑdDWHrÌ[°DW=Hs™hDW=Hs™h.DW]DVˆDWDW.DVˆDWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BLmôBLÛèmRNA-1273-P301 mRNA-1273-P301-US375-2250US3752250US375USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW=DVˆHr)¸DV¤Hr9ÑdDV¤Hr9ÑdDWHrÌ[°DW=Hs™hDW=Hs™h.DW]DVˆDWDW.DVˆDWDW. >=18 and <65 Years and Not at RiskABºNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BLÛèBLIÜmRNA-1273-P301 mRNA-1273-P301-US375-2319US3752319US375USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW/DVŽHrù,DV§Hr=«¤DV§Hr=«¤DWHrÐDDW/Hrñ|DW/Hrñ|.DW]DVŽDWDW.DVŽDWDW. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BjmRNA-1273-P301 mRNA-1273-P301-US375-2344US3752344US375USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVDVDVHr^\DVHrEŒ¬DVHrEŒ¬......DWDWDVDW DWDW*DVDW DWDW* >=18 and <65 Years and Not at RiskAB~Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B1mRNA-1273-P301 mRNA-1273-P301-US375-2347US3752347US375USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWADVHrnLDVªHrAÈ8DVªHrAÈ8DW%HräìDWAHsù¨DWAHsù¨.DW]DVDW$DW%.DVDW$DW%. Diabetes >=65 Years A0B´Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B,mRNA-1273-P301 mRNA-1273-P301-US375-2393US3752393US375USABJYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYNNNYYNNNYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV‘DV³DV‘Hr!ôDV³HrM¢¬DV³HrM¢¬.......DW]DV‘DW)DW*.DV‘DW)DW*. >=65 Years A0B«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B}mRNA-1273-P301 mRNA-1273-P301-US376-2061US3762061US376USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWKDV‰Hr.ÐDV«HrBædDV«HrBædDW(HrèDWKHs5ÈDWKHs5È.DW]DV‰DW'DW(.DV‰DW'DW(. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BƒmRNA-1273-P301 mRNA-1273-P301-US376-2061US3762061US376USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWKDV‰Hr.ÐDV«HrBædDV«HrBædDW(HrèDWKHs5ÈDWKHs5È.DW]DV‰DW'DW(.DV‰DW'DW(. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BƒBƒmðmRNA-1273-P301 mRNA-1273-P301-US376-2061US3762061US376USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWKDV‰Hr.ÐDV«HrBædDV«HrBædDW(HrèDWKHs5ÈDWKHs5È.DW]DV‰DW'DW(.DV‰DW'DW(. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BƒmðBƒÛèmRNA-1273-P301 mRNA-1273-P301-US376-2126US3762126US376USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrTDV«HrBêØDV«HrBêØDW*Hrê™DWKHs DWKHs .DW]DVDWDW.DVDW)DW*. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BHmRNA-1273-P301 mRNA-1273-P301-US376-2126US3762126US376USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrTDV«HrBêØDV«HrBêØDW*Hrê™DWKHs DWKHs .DW]DVDWDW.DVDW)DW*. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BHBHmômRNA-1273-P301 mRNA-1273-P301-US376-2126US3762126US376USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrTDV«HrBêØDV«HrBêØDW*Hrê™DWKHs DWKHs .DW]DVDWDW.DVDW)DW*. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BHmôBHÛèmRNA-1273-P301 mRNA-1273-P301-US376-2137US3762137US376USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrEüDV«HrC>üDV«HrC>üDW/Hrñ5„DWKHs|DWKHs|.DW]DVDW.DW/.DVDW.DW/. >=65 Years A0B³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B€mRNA-1273-P301 mRNA-1273-P301-US376-2137US3762137US376USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrEüDV«HrC>üDV«HrC>üDW/Hrñ5„DWKHs|DWKHs|.DW]DVDW.DW/.DVDW.DW/. >=65 Years A0B³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B€B€mðmRNA-1273-P301 mRNA-1273-P301-US376-2137US3762137US376USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWKDVHrEüDV«HrC>üDV«HrC>üDW/Hrñ5„DWKHs|DWKHs|.DW]DVDW.DW/.DVDW.DW/. >=65 Years A0B³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B€mðB€ÛèmRNA-1273-P301 mRNA-1273-P301-US377-2004US3772004US377USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW+DVsHqùwàDVŽHrlDVŽHrlDWHrÇàDW+HrìDW+Hrì.DW]DVsDWDW .DVsDWDW. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBbmRNA-1273-P301 mRNA-1273-P301-US377-2004US3772004US377USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVsDW+DVsHqùwàDVŽHrlDVŽHrlDWHrÇàDW+HrìDW+Hrì.DW]DVsDWDW .DVsDWDW. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBbBbmômRNA-1273-P301 mRNA-1273-P301-US377-2026US3772026US377USABBYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW7DVuHqüôDV˜Hr*?œDV˜Hr*?œDWHrÑ©lDW7HrûÕ¬DW7HrûÕ¬.DW]DVuDWDW.DVuDWDW. >=65 Years A0BÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‚mRNA-1273-P301 mRNA-1273-P301-US377-2035US3772035US377USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW3DVyHrX¬DVœHr/fèDVœHr/fèDWHrÑ¬´DW3HröA(DW3HröA(.DW]DVyDWDW.DVyDWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BbmRNA-1273-P301 mRNA-1273-P301-US377-2035US3772035US377USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW3DVyHrX¬DVœHr/fèDVœHr/fèDWHrÑ¬´DW3HröA(DW3HröA(.DW]DVyDWDW.DVyDWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BbBbmômRNA-1273-P301 mRNA-1273-P301-US377-2035US3772035US377USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW3DVyHrX¬DVœHr/fèDVœHr/fèDWHrÑ¬´DW3HröA(DW3HröA(.DW]DVyDWDW.DVyDWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BbmôBbÛèmRNA-1273-P301 mRNA-1273-P301-US377-2035US3772035US377USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW3DVyHrX¬DVœHr/fèDVœHr/fèDWHrÑ¬´DW3HröA(DW3HröA(.DW]DVyDWDW.DVyDWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BbÛèBbIÜmRNA-1273-P301 mRNA-1273-P301-US377-2064US3772064US377USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV|DVœDV|Hr àDVœHr/)€DVœHr/)€.......DW]DV|DW!DW".DV|DW!DW". >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BZmRNA-1273-P301 mRNA-1273-P301-US377-2095US3772095US377USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWDDV‚HräØDVœHr/6ÜDVœHr/6ÜDW"Hrà+TDWDHs®hDWDHs®h.DW]DV‚DW!DW".DV‚DW!DW". >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBpmRNA-1273-P301 mRNA-1273-P301-US377-2095US3772095US377USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWDDV‚HräØDVœHr/6ÜDVœHr/6ÜDW"Hrà+TDWDHs®hDWDHs®h.DW]DV‚DW!DW".DV‚DW!DW". >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBpBpmômRNA-1273-P301 mRNA-1273-P301-US377-2106US3772106US377USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWLDVƒHrYøDV Hr4”ˆDV Hr4”ˆDW+Hrë×`DWLHsäDWLHsä.DW]DVƒDW"DW#.DVƒDW*DW+. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B‹mRNA-1273-P301 mRNA-1273-P301-US377-2159US3772159US377USABLYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWZDVŠHrÌDV§Hr=ùìDV§Hr=ùìDW:Hrÿ °DWZHs)ó$DWZHs)ó$.DW]DVŠDWDW.DVŠDW9DW:.Chronic Lung Disease >=65 Years A0B·Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BbmRNA-1273-P301 mRNA-1273-P301-US377-2159US3772159US377USABLYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWZDVŠHrÌDV§Hr=ùìDV§Hr=ùìDW:Hrÿ °DWZHs)ó$DWZHs)ó$.DW]DVŠDWDW.DVŠDW9DW:.Chronic Lung Disease >=65 Years A0B·Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BbBbmômRNA-1273-P301 mRNA-1273-P301-US377-2159US3772159US377USABLYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWZDVŠHrÌDV§Hr=ùìDV§Hr=ùìDW:Hrÿ °DWZHs)ó$DWZHs)ó$.DW]DVŠDWDW.DVŠDW9DW:.Chronic Lung Disease >=65 Years A0B·Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BbmôBbÛèmRNA-1273-P301 mRNA-1273-P301-US377-2159US3772159US377USABLYEARS>=65 Years A0>=65 Years A >=75 Years A0>=75 and <85 YearsA0 .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWZDVŠHrÌDV§Hr=ùìDV§Hr=ùìDW:Hrÿ °DWZHs)ó$DWZHs)ó$.DW]DVŠDWDW.DVŠDW9DW:.Chronic Lung Disease >=65 Years A0B·Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BbÛèBbIÜmRNA-1273-P301 mRNA-1273-P301-US377-2182US3772182US377USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW:DVŽHr¸@DV¬HrD@DV¬HrD@DWHrÎ°àDW:Hrÿ¾8DW:Hrÿ¾8.DW]DVŽDWDW.DVŽDWDW. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BMmRNA-1273-P301 mRNA-1273-P301-US377-2184US3772184US377USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW+DVŽHr·ŒDV¬HrD@ÌDV¬HrD@ÌDWHrÅÔÔDW+HrëÕøDW+HrëÕø.DW]DVŽDW DW.DVŽDW DW. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BQmRNA-1273-P301 mRNA-1273-P301-US377-2184US3772184US377USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW+DVŽHr·ŒDV¬HrD@ÌDV¬HrD@ÌDWHrÅÔÔDW+HrëÕøDW+HrëÕø.DW]DVŽDW DW.DVŽDW DW. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BQBQmômRNA-1273-P301 mRNA-1273-P301-US377-2184US3772184US377USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW+DVŽHr·ŒDV¬HrD@ÌDV¬HrD@ÌDWHrÅÔÔDW+HrëÕøDW+HrëÕø.DW]DVŽDW DW.DVŽDW DW. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BQmôBQÛèmRNA-1273-P301 mRNA-1273-P301-US377-2184US3772184US377USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW+DVŽHr·ŒDV¬HrD@ÌDV¬HrD@ÌDWHrÅÔÔDW+HrëÕøDW+HrëÕø.DW]DVŽDW DW.DVŽDW DW. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BQÛèBQIÜmRNA-1273-P301 mRNA-1273-P301-US377-2246US3772246US377USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWFDV˜Hr*;ÜDVµHrP9ôDVµHrP9ôDWHrÙ‹ DWFHsPxDWFHsPx.DW]DV˜DWDW.DV˜DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B@mRNA-1273-P301 mRNA-1273-P301-US377-2246US3772246US377USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWFDV˜Hr*;ÜDVµHrP9ôDVµHrP9ôDWHrÙ‹ DWFHsPxDWFHsPx.DW]DV˜DWDW.DV˜DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B@B@mômRNA-1273-P301 mRNA-1273-P301-US377-2246US3772246US377USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWFDV˜Hr*;ÜDVµHrP9ôDVµHrP9ôDWHrÙ‹ DWFHsPxDWFHsPx.DW]DV˜DWDW.DV˜DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B@môB@ÛèmRNA-1273-P301 mRNA-1273-P301-US377-2246US3772246US377USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWFDV˜Hr*;ÜDVµHrP9ôDVµHrP9ôDWHrÙ‹ DWFHsPxDWFHsPx.DW]DV˜DWDW.DV˜DWDW. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B@ÛèB@IÜmRNA-1273-P301 mRNA-1273-P301-US377-2251US3772251US377USAB-YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWFDV™Hr+=18 and <65 Years and at Risk A B¥Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBˆmRNA-1273-P301 mRNA-1273-P301-US377-2251US3772251US377USAB-YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWFDV™Hr+=18 and <65 Years and at Risk A B¥Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBˆBˆmðmRNA-1273-P301 mRNA-1273-P301-US378-2016US3782016US378USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrL¤DV™Hr+/`DV™Hr+/`.......DW]DV}DVøDVùDVùDV}DVøDVùDVù >=18 and <65 Years and Not at RiskABaNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B:mRNA-1273-P301 mRNA-1273-P301-US378-2016US3782016US378USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrL¤DV™Hr+/`DV™Hr+/`.......DW]DV}DVøDVùDVùDV}DVøDVùDVù >=18 and <65 Years and Not at RiskABaNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B:B:mômRNA-1273-P301 mRNA-1273-P301-US378-2016US3782016US378USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrL¤DV™Hr+/`DV™Hr+/`.......DW]DV}DVøDVùDVùDV}DVøDVùDVù >=18 and <65 Years and Not at RiskABaNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B:môB:ÛæmRNA-1273-P301 mRNA-1273-P301-US378-2016US3782016US378USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV}DV™DV}HrL¤DV™Hr+/`DV™Hr+/`.......DW]DV}DVøDVùDVùDV}DVøDVùDVù >=18 and <65 Years and Not at RiskABaNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B:ÛæB:IÚmRNA-1273-P301 mRNA-1273-P301-US378-2033US3782033US378USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW+DV€Hr a¸DVœHr/WèDVœHr/WèDWHrÇÐDW+HrëœŒDW+HrëœŒ.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BJmRNA-1273-P301 mRNA-1273-P301-US378-2033US3782033US378USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW+DV€Hr a¸DVœHr/WèDVœHr/WèDWHrÇÐDW+HrëœŒDW+HrëœŒ.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BJBJmômRNA-1273-P301 mRNA-1273-P301-US378-2033US3782033US378USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW+DV€Hr a¸DVœHr/WèDVœHr/WèDWHrÇÐDW+HrëœŒDW+HrëœŒ.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BJmôBJÛèmRNA-1273-P301 mRNA-1273-P301-US378-2033US3782033US378USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DW+DV€Hr a¸DVœHr/WèDVœHr/WèDWHrÇÐDW+HrëœŒDW+HrëœŒ.DW]DV€DWDW.DV€DWDW. >=18 and <65 Years and Not at RiskABÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BJÛèBJIÜmRNA-1273-P301 mRNA-1273-P301-US378-2053US3782053US378USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWDDV‚Hr 1@DV£Hr8nŒDV£Hr8nŒDWDHs ,DWDHs ,...DW]DV‚DWCDWD.DV‚DWCDWD. Severe Obesity >=18 and <65 Years and at Risk A B»Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BemRNA-1273-P301 mRNA-1273-P301-US378-2053US3782053US378USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWDDV‚Hr 1@DV£Hr8nŒDV£Hr8nŒDWDHs ,DWDHs ,...DW]DV‚DWCDWD.DV‚DWCDWD. Severe Obesity >=18 and <65 Years and at Risk A B»Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BeBemômRNA-1273-P301 mRNA-1273-P301-US378-2053US3782053US378USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWDDV‚Hr 1@DV£Hr8nŒDV£Hr8nŒDWDHs ,DWDHs ,...DW]DV‚DWCDWD.DV‚DWCDWD. Severe Obesity >=18 and <65 Years and at Risk A B»Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BemôBeÛèmRNA-1273-P301 mRNA-1273-P301-US378-2053US3782053US378USAB)YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DWDDV‚Hr 1@DV£Hr8nŒDV£Hr8nŒDWDHs ,DWDHs ,...DW]DV‚DWCDWD.DV‚DWCDWD. Severe Obesity >=18 and <65 Years and at Risk A B»Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BeÛèBeIÜmRNA-1273-P301 mRNA-1273-P301-US378-2071US3782071US378USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWDDV„HrÀDV£Hr8~¸DV£Hr8~¸DWDHsÄèDWDHsÄè...DW]DV„DWCDWD.DV„DWCDWD. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BbmRNA-1273-P301 mRNA-1273-P301-US378-2071US3782071US378USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWDDV„HrÀDV£Hr8~¸DV£Hr8~¸DWDHsÄèDWDHsÄè...DW]DV„DWCDWD.DV„DWCDWD. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BbBbmômRNA-1273-P301 mRNA-1273-P301-US378-2071US3782071US378USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWDDV„HrÀDV£Hr8~¸DV£Hr8~¸DWDHsÄèDWDHsÄè...DW]DV„DWCDWD.DV„DWCDWD. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BbmôBbÛèmRNA-1273-P301 mRNA-1273-P301-US378-2082US3782082US378USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW=DVˆHrØÜDV¤Hr9º¨DV¤Hr9º¨DWHrÕ7¼DW=HsVØDW=HsVØ.DW]DVˆDWDW.DVˆDWDW. Severe Obesity >=18 and <65 Years and at Risk A BºNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BGmRNA-1273-P301 mRNA-1273-P301-US378-2082US3782082US378USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW=DVˆHrØÜDV¤Hr9º¨DV¤Hr9º¨DWHrÕ7¼DW=HsVØDW=HsVØ.DW]DVˆDWDW.DVˆDWDW. Severe Obesity >=18 and <65 Years and at Risk A BºNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BGBGmômRNA-1273-P301 mRNA-1273-P301-US378-2082US3782082US378USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW=DVˆHrØÜDV¤Hr9º¨DV¤Hr9º¨DWHrÕ7¼DW=HsVØDW=HsVØ.DW]DVˆDWDW.DVˆDWDW. Severe Obesity >=18 and <65 Years and at Risk A BºNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BGmôBGÛèmRNA-1273-P301 mRNA-1273-P301-US378-2082US3782082US378USAB4YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW=DVˆHrØÜDV¤Hr9º¨DV¤Hr9º¨DWHrÕ7¼DW=HsVØDW=HsVØ.DW]DVˆDWDW.DVˆDWDW. Severe Obesity >=18 and <65 Years and at Risk A BºNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BGÛèBGIÜmRNA-1273-P301 mRNA-1273-P301-US378-2136US3782136US378USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWDDVHr|ˆDV¬HrDRØDV¬HrDRØDW(Hrç½`DWDHs£dDWDHs£d.DW]DVDW'DW(.DVDW'DW(. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BFmRNA-1273-P301 mRNA-1273-P301-US378-2136US3782136US378USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWDDVHr|ˆDV¬HrDRØDV¬HrDRØDW(Hrç½`DWDHs£dDWDHs£d.DW]DVDW'DW(.DVDW'DW(. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BFBFmômRNA-1273-P301 mRNA-1273-P301-US378-2136US3782136US378USAB-YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWDDVHr|ˆDV¬HrDRØDV¬HrDRØDW(Hrç½`DWDHs£dDWDHs£d.DW]DVDW'DW(.DVDW'DW(. >=18 and <65 Years and Not at RiskAB²Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BFmôBFÛèmRNA-1273-P301 mRNA-1273-P301-US378-2168US3782168US378USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW=DV™Hr+7XDV¹HrUc DV¹HrUc DWHrÕ DW=Hs›HDW=Hs›H.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B>mRNA-1273-P301 mRNA-1273-P301-US378-2168US3782168US378USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW=DV™Hr+7XDV¹HrUc DV¹HrUc DWHrÕ DW=Hs›HDW=Hs›H.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B>B>mômRNA-1273-P301 mRNA-1273-P301-US378-2168US3782168US378USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW=DV™Hr+7XDV¹HrUc DV¹HrUc DWHrÕ DW=Hs›HDW=Hs›H.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B>môB>ÛæmRNA-1273-P301 mRNA-1273-P301-US378-2168US3782168US378USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW=DV™Hr+7XDV¹HrUc DV¹HrUc DWHrÕ DW=Hs›HDW=Hs›H.DW]DV™DWDW.DV™DWDW. >=18 and <65 Years and Not at RiskAB¥Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B>ÛæB>IÚmRNA-1273-P301 mRNA-1273-P301-US379-2052US3792052US379USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVDV¹DVHr0 DV¹HrU´tDV¹HrU´t.......DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB¥Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBEmRNA-1273-P301 mRNA-1273-P301-US379-2052US3792052US379USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVDV¹DVHr0 DV¹HrU´tDV¹HrU´t.......DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB¥Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBEBEmômRNA-1273-P301 mRNA-1273-P301-US379-2080US3792080US379USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DWADV¬HrDaœDVÏHrrs˜DVÏHrrs˜DW%HrãèÀDWAHsÁ¤DWAHsÁ¤.DW]DV¬DW$DW%.DV¬DW$DW%. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBBmRNA-1273-P301 mRNA-1273-P301-US379-2080US3792080US379USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¬DWADV¬HrDaœDVÏHrrs˜DVÏHrrs˜DW%HrãèÀDWAHsÁ¤DWAHsÁ¤.DW]DV¬DW$DW%.DV¬DW$DW%. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBBBmômRNA-1273-P301 mRNA-1273-P301-US379-2090US3792090US379USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DWADV³HrM±pDVÐHrsÀ¤DVÐHrsÀ¤DWHrÖ¾¬DWAHsõ4DWAHsõ4.DW]DV³DWDW.DV³DWDW. >=18 and <65 Years and Not at RiskABŽMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBDmRNA-1273-P301 mRNA-1273-P301-US379-2090US3792090US379USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV³DWADV³HrM±pDVÐHrsÀ¤DVÐHrsÀ¤DWHrÖ¾¬DWAHsõ4DWAHsõ4.DW]DV³DWDW.DV³DWDW. >=18 and <65 Years and Not at RiskABŽMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBDBDmômRNA-1273-P301 mRNA-1273-P301-US380-2034US3802034US380USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW*DVˆHrtDV£Hr8kDDV£Hr8kDDWHrÅª¤DW*Hrê…àDW*Hrê…à.DW]DVˆDW DW.DVˆDW DW. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BHmRNA-1273-P301 mRNA-1273-P301-US380-2034US3802034US380USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW*DVˆHrtDV£Hr8kDDV£Hr8kDDWHrÅª¤DW*Hrê…àDW*Hrê…à.DW]DVˆDW DW.DVˆDW DW. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BHBHmômRNA-1273-P301 mRNA-1273-P301-US380-2034US3802034US380USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW*DVˆHrtDV£Hr8kDDV£Hr8kDDWHrÅª¤DW*Hrê…àDW*Hrê…à.DW]DVˆDW DW.DVˆDW DW. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BHmôBHÛèmRNA-1273-P301 mRNA-1273-P301-US380-2034US3802034US380USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW*DVˆHrtDV£Hr8kDDV£Hr8kDDWHrÅª¤DW*Hrê…àDW*Hrê…à.DW]DVˆDW DW.DVˆDW DW. >=65 Years A0B»Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BHÛèBHIÜmRNA-1273-P301 mRNA-1273-P301-US380-2091US3802091US380USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW2DVHrDV«HrCDV«HrCDWHrÈ<DW2Hrõ3ÜDW2Hrõ3Ü.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B?mRNA-1273-P301 mRNA-1273-P301-US380-2091US3802091US380USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW2DVHrDV«HrCDV«HrCDWHrÈ<DW2Hrõ3ÜDW2Hrõ3Ü.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B?B?mômRNA-1273-P301 mRNA-1273-P301-US380-2091US3802091US380USAB2YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW2DVHrDV«HrCDV«HrCDWHrÈ<DW2Hrõ3ÜDW2Hrõ3Ü.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B?môB?ÛæmRNA-1273-P301 mRNA-1273-P301-US380-2109US3802109US380USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWZDVHr£4DV®HrFøäDV®HrFøäDWZHs)ÒDWZHs)Ò...DW]DVDW.DW/.DVDWYDWZ. Severe Obesity >=18 and <65 Years and at Risk A B°Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BƒmRNA-1273-P301 mRNA-1273-P301-US380-2109US3802109US380USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWZDVHr£4DV®HrFøäDV®HrFøäDWZHs)ÒDWZHs)Ò...DW]DVDW.DW/.DVDWYDWZ. Severe Obesity >=18 and <65 Years and at Risk A B°Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BƒBƒmðmRNA-1273-P301 mRNA-1273-P301-US380-2109US3802109US380USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWZDVHr£4DV®HrFøäDV®HrFøäDWZHs)ÒDWZHs)Ò...DW]DVDW.DW/.DVDWYDWZ. Severe Obesity >=18 and <65 Years and at Risk A B°Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BƒmðBƒÛèmRNA-1273-P301 mRNA-1273-P301-US380-2109US3802109US380USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWZDVHr£4DV®HrFøäDV®HrFøäDWZHs)ÒDWZHs)Ò...DW]DVDW.DW/.DVDWYDWZ. Severe Obesity >=18 and <65 Years and at Risk A B°Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BƒÛèBƒIØmRNA-1273-P301 mRNA-1273-P301-US380-2220US3802220US380USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW?DV™Hr+U”DV¹HrUª$DV¹HrUª$DW?Hs.ÐDW?Hs.Ð...DW]DV™DWDW.DV™DW>DW?. Significant Cardiac Disease >=18 and <65 Years and at Risk A B¥Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BemRNA-1273-P301 mRNA-1273-P301-US380-2220US3802220US380USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW?DV™Hr+U”DV¹HrUª$DV¹HrUª$DW?Hs.ÐDW?Hs.Ð...DW]DV™DWDW.DV™DW>DW?. Significant Cardiac Disease >=18 and <65 Years and at Risk A B¥Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BeBemômRNA-1273-P301 mRNA-1273-P301-US380-2220US3802220US380USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW?DV™Hr+U”DV¹HrUª$DV¹HrUª$DW?Hs.ÐDW?Hs.Ð...DW]DV™DWDW.DV™DW>DW?. Significant Cardiac Disease >=18 and <65 Years and at Risk A B¥Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BemôBeÛèmRNA-1273-P301 mRNA-1273-P301-US380-2220US3802220US380USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DW?DV™Hr+U”DV¹HrUª$DV¹HrUª$DW?Hs.ÐDW?Hs.Ð...DW]DV™DWDW.DV™DW>DW?. Significant Cardiac Disease >=18 and <65 Years and at Risk A B¥Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BeÛèBeIÜmRNA-1273-P301 mRNA-1273-P301-US381-2044US3812044US381USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWRDVtHqú”àDVŽHr(DVŽHr(DW/Hrñ!˜DWRHszÔDWRHszÔ.DW]DVtDW.DW/.DVtDW.DW/. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B6mRNA-1273-P301 mRNA-1273-P301-US381-2044US3812044US381USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWRDVtHqú”àDVŽHr(DVŽHr(DW/Hrñ!˜DWRHszÔDWRHszÔ.DW]DVtDW.DW/.DVtDW.DW/. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B6B6mômRNA-1273-P301 mRNA-1273-P301-US381-2044US3812044US381USAB<YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDWRDVtHqú”àDVŽHr(DVŽHr(DW/Hrñ!˜DWRHszÔDWRHszÔ.DW]DVtDW.DW/.DVtDW.DW/. >=18 and <65 Years and Not at RiskABÐNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B6môB6ÛæmRNA-1273-P301 mRNA-1273-P301-US381-2046US3812046US381USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVtDW3DVtHqú¥DVŽHrÐ DVŽHrÐ DWHrÒÀTDW3HröUPDW3HröUP.DW]DVtDWDW.DVtDWDW. Significant Cardiac Disease >=65 Years A0BÐNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B|mRNA-1273-P301 mRNA-1273-P301-US381-2111US3812111US381USAB3YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDWRDVyHrcìDV’Hr"EøDV’Hr"EøDW7HrûÄTDWRHsVDDWRHsVD.DW]DVyDW6DW7.DVyDW6DW7.Chronic Lung Disease >=18 and <65 Years and at Risk A BÌNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B~mRNA-1273-P301 mRNA-1273-P301-US381-2114US3812114US381USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW>DVyHr}DV–Hr'®äDV–Hr'®äDW"HrßáøDW>Hs½èDW>Hs½è.DW]DVyDW!DW".DVyDW!DW". >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BrmRNA-1273-P301 mRNA-1273-P301-US381-2114US3812114US381USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW>DVyHr}DV–Hr'®äDV–Hr'®äDW"HrßáøDW>Hs½èDW>Hs½è.DW]DVyDW!DW".DVyDW!DW". >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BrBrmômRNA-1273-P301 mRNA-1273-P301-US381-2114US3812114US381USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW>DVyHr}DV–Hr'®äDV–Hr'®äDW"HrßáøDW>Hs½èDW>Hs½è.DW]DVyDW!DW".DVyDW!DW". >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BrmôBrÛèmRNA-1273-P301 mRNA-1273-P301-US381-2114US3812114US381USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDW>DVyHr}DV–Hr'®äDV–Hr'®äDW"HrßáøDW>Hs½èDW>Hs½è.DW]DVyDW!DW".DVyDW!DW". >=18 and <65 Years and Not at RiskABÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BrÛèBrIÜmRNA-1273-P301 mRNA-1273-P301-US381-2137US3812137US381USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWKDV{Hr(DV™Hr+ XDV™Hr+ XDW0HròKôDWKHsÜ@DWKHsÜ@.DW]DV{DW/DW0.DV{DW/DW0. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BpmRNA-1273-P301 mRNA-1273-P301-US381-2137US3812137US381USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWKDV{Hr(DV™Hr+ XDV™Hr+ XDW0HròKôDWKHsÜ@DWKHsÜ@.DW]DV{DW/DW0.DV{DW/DW0. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BpBpmômRNA-1273-P301 mRNA-1273-P301-US381-2137US3812137US381USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWKDV{Hr(DV™Hr+ XDV™Hr+ XDW0HròKôDWKHsÜ@DWKHsÜ@.DW]DV{DW/DW0.DV{DW/DW0. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BpmôBpÛèmRNA-1273-P301 mRNA-1273-P301-US381-2137US3812137US381USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWKDV{Hr(DV™Hr+ XDV™Hr+ XDW0HròKôDWKHsÜ@DWKHsÜ@.DW]DV{DW/DW0.DV{DW/DW0. >=18 and <65 Years and Not at RiskABÅNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BpÛèBpIÜmRNA-1273-P301 mRNA-1273-P301-US381-2139US3812139US381USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWFDV{HrÀ`DV˜Hr)ú´DV˜Hr)ú´DW*Hrêd\DWFHsc°DWFHsc°.DW]DV{DW)DW*.DV{DW)DW*. >=65 Years A0BÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BgmRNA-1273-P301 mRNA-1273-P301-US381-2139US3812139US381USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWFDV{HrÀ`DV˜Hr)ú´DV˜Hr)ú´DW*Hrêd\DWFHsc°DWFHsc°.DW]DV{DW)DW*.DV{DW)DW*. >=65 Years A0BÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BgBgmômRNA-1273-P301 mRNA-1273-P301-US381-2139US3812139US381USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWFDV{HrÀ`DV˜Hr)ú´DV˜Hr)ú´DW*Hrêd\DWFHsc°DWFHsc°.DW]DV{DW)DW*.DV{DW)DW*. >=65 Years A0BÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BgmôBgÛèmRNA-1273-P301 mRNA-1273-P301-US381-2139US3812139US381USABEYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV{DWFDV{HrÀ`DV˜Hr)ú´DV˜Hr)ú´DW*Hrêd\DWFHsc°DWFHsc°.DW]DV{DW)DW*.DV{DW)DW*. >=65 Years A0BÆNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BgÛèBgIÜmRNA-1273-P301 mRNA-1273-P301-US381-2148US3812148US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV{DV—DV{Hr ¼DV—Hr) DV—Hr) .......DW]DV{DWLDWM.DV{DWLDWM. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB”mRNA-1273-P301 mRNA-1273-P301-US381-2148US3812148US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV{DV—DV{Hr ¼DV—Hr) DV—Hr) .......DW]DV{DWLDWM.DV{DWLDWM. >=18 and <65 Years and Not at RiskABÇNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB”B”mðmRNA-1273-P301 mRNA-1273-P301-US381-2153US3812153US381USAB1YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV|DWHDV|HrûØDVHr0¼ÜDVHr0¼ÜDW,Hrí30DWHHs÷tDWHHs÷t.DW]DV|DW+DW,.DV|DW+DW,. >=18 and <65 Years and Not at RiskABÁNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B„mRNA-1273-P301 mRNA-1273-P301-US381-2168US3812168US381USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW8DV}HrNDV Hr4gLDV Hr4gLDWHrÚÌ¸DW8HrüÞHDW8HrüÞH.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBTmRNA-1273-P301 mRNA-1273-P301-US381-2168US3812168US381USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DW8DV}HrNDV Hr4gLDV Hr4gLDWHrÚÌ¸DW8HrüÞHDW8HrüÞH.DW]DV}DWDW.DV}DWDW. >=18 and <65 Years and Not at RiskAB¾Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBTBTmômRNA-1273-P301 mRNA-1273-P301-US381-2175US3812175US381USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWTDV}Hrž¬DV˜Hr*$lDV˜Hr*$lDWTHs!á\DWTHs!á\...DW]DV}DWSDWT.DV}DWSDWT.Chronic Lung Disease Severe Obesity >=18 and <65 Years and at Risk A BÆNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BemRNA-1273-P301 mRNA-1273-P301-US381-2175US3812175US381USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWTDV}Hrž¬DV˜Hr*$lDV˜Hr*$lDWTHs!á\DWTHs!á\...DW]DV}DWSDWT.DV}DWSDWT.Chronic Lung Disease Severe Obesity >=18 and <65 Years and at Risk A BÆNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BeBemômRNA-1273-P301 mRNA-1273-P301-US381-2175US3812175US381USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWTDV}Hrž¬DV˜Hr*$lDV˜Hr*$lDWTHs!á\DWTHs!á\...DW]DV}DWSDWT.DV}DWSDWT.Chronic Lung Disease Severe Obesity >=18 and <65 Years and at Risk A BÆNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BemôBeÛèmRNA-1273-P301 mRNA-1273-P301-US381-2175US3812175US381USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV}DWTDV}Hrž¬DV˜Hr*$lDV˜Hr*$lDWTHs!á\DWTHs!á\...DW]DV}DWSDWT.DV}DWSDWT.Chronic Lung Disease Severe Obesity >=18 and <65 Years and at Risk A BÆNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BeÛèBeIÜmRNA-1273-P301 mRNA-1273-P301-US381-2216US3812216US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‚DVŸDV‚Hr ¤DVŸHr3[hDVŸHr3[h.......DW]DV‚DWDWDWDV‚DWDWDW >=18 and <65 Years and Not at RiskABiNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B5mRNA-1273-P301 mRNA-1273-P301-US381-2216US3812216US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‚DVŸDV‚Hr ¤DVŸHr3[hDVŸHr3[h.......DW]DV‚DWDWDWDV‚DWDWDW >=18 and <65 Years and Not at RiskABiNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B5B5mômRNA-1273-P301 mRNA-1273-P301-US381-2216US3812216US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‚DVŸDV‚Hr ¤DVŸHr3[hDVŸHr3[h.......DW]DV‚DWDWDWDV‚DWDWDW >=18 and <65 Years and Not at RiskABiNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B5môB5ÛæmRNA-1273-P301 mRNA-1273-P301-US381-2216US3812216US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‚DVŸDV‚Hr ¤DVŸHr3[hDVŸHr3[h.......DW]DV‚DWDWDWDV‚DWDWDW >=18 and <65 Years and Not at RiskABiNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B5ÛæB5IÚmRNA-1273-P301 mRNA-1273-P301-US381-2224US3812224US381USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWSDVƒHr^¨DVœHr/94DVœHr/94DW7Hrûš`DWSHs ‚DDWSHs ‚D.DW]DVƒDW6DW7.DVƒDW6DW7. >=65 Years A0BÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BmRNA-1273-P301 mRNA-1273-P301-US381-2224US3812224US381USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWSDVƒHr^¨DVœHr/94DVœHr/94DW7Hrûš`DWSHs ‚DDWSHs ‚D.DW]DVƒDW6DW7.DVƒDW6DW7. >=65 Years A0BÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BBmðmRNA-1273-P301 mRNA-1273-P301-US381-2224US3812224US381USABCYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDWSDVƒHr^¨DVœHr/94DVœHr/94DW7Hrûš`DWSHs ‚DDWSHs ‚D.DW]DVƒDW6DW7.DVƒDW6DW7. >=65 Years A0BÂNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US381-2263US3812263US381USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV‰DV¥DV‰Hr"ÜDV¥Hr;;DV¥Hr;;.......DW]DV‰DW*DW+.DV‰DW*DW+. Severe ObesityDiabetes >=65 Years A0B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BNmRNA-1273-P301 mRNA-1273-P301-US381-2263US3812263US381USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV‰DV¥DV‰Hr"ÜDV¥Hr;;DV¥Hr;;.......DW]DV‰DW*DW+.DV‰DW*DW+. Severe ObesityDiabetes >=65 Years A0B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BNBNmômRNA-1273-P301 mRNA-1273-P301-US381-2263US3812263US381USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV‰DV¥DV‰Hr"ÜDV¥Hr;;DV¥Hr;;.......DW]DV‰DW*DW+.DV‰DW*DW+. Severe ObesityDiabetes >=65 Years A0B¹Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BNmôBNÛèmRNA-1273-P301 mRNA-1273-P301-US381-2272US3812272US381USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‰DV¦DV‰HrJðDV¦Hr<˜¸DV¦Hr<˜¸.......DW]DV‰DVùDVúDVúDV‰DVùDVúDVú >=18 and <65 Years and Not at RiskABUNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BOmRNA-1273-P301 mRNA-1273-P301-US381-2272US3812272US381USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‰DV¦DV‰HrJðDV¦Hr<˜¸DV¦Hr<˜¸.......DW]DV‰DVùDVúDVúDV‰DVùDVúDVú >=18 and <65 Years and Not at RiskABUNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BOBOmômRNA-1273-P301 mRNA-1273-P301-US381-2272US3812272US381USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‰DV¦DV‰HrJðDV¦Hr<˜¸DV¦Hr<˜¸.......DW]DV‰DVùDVúDVúDV‰DVùDVúDVú >=18 and <65 Years and Not at RiskABUNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BOmôBOÛèmRNA-1273-P301 mRNA-1273-P301-US381-2272US3812272US381USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‰DV¦DV‰HrJðDV¦Hr<˜¸DV¦Hr<˜¸.......DW]DV‰DVùDVúDVúDV‰DVùDVúDVú >=18 and <65 Years and Not at RiskABUNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BOÛèBOIÜmRNA-1273-P301 mRNA-1273-P301-US381-2280US3812280US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWSDVŠHr¥XDV¦Hr<¡dDV¦Hr<¡dDW9HrþrDWSHs ÜDWSHs Ü.DW]DVŠDW8DW9.DVŠDW8DW9. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BTmRNA-1273-P301 mRNA-1273-P301-US381-2280US3812280US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWSDVŠHr¥XDV¦Hr<¡dDV¦Hr<¡dDW9HrþrDWSHs ÜDWSHs Ü.DW]DVŠDW8DW9.DVŠDW8DW9. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BTBTmômRNA-1273-P301 mRNA-1273-P301-US381-2280US3812280US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWSDVŠHr¥XDV¦Hr<¡dDV¦Hr<¡dDW9HrþrDWSHs ÜDWSHs Ü.DW]DVŠDW8DW9.DVŠDW8DW9. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BTmôBTÛèmRNA-1273-P301 mRNA-1273-P301-US381-2280US3812280US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWSDVŠHr¥XDV¦Hr<¡dDV¦Hr<¡dDW9HrþrDWSHs ÜDWSHs Ü.DW]DVŠDW8DW9.DVŠDW8DW9. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BTÛèBTIÜmRNA-1273-P301 mRNA-1273-P301-US381-2306US3812306US381USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDV®DVHrvèDV®HrG),DV®HrG),.......DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BTmRNA-1273-P301 mRNA-1273-P301-US381-2317US3812317US381USAB7YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV’DV®DV’Hr"U4DV®HrFø0DV®HrFø0.......DW]DV’DWoDWp.DV’DWoDWp.Chronic Lung Disease >=18 and <65 Years and at Risk A B°Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BmmRNA-1273-P301 mRNA-1273-P301-US381-2317US3812317US381USAB7YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV’DV®DV’Hr"U4DV®HrFø0DV®HrFø0.......DW]DV’DWoDWp.DV’DWoDWp.Chronic Lung Disease >=18 and <65 Years and at Risk A B°Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BmBmmômRNA-1273-P301 mRNA-1273-P301-US381-2317US3812317US381USAB7YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV’DV®DV’Hr"U4DV®HrFø0DV®HrFø0.......DW]DV’DWoDWp.DV’DWoDWp.Chronic Lung Disease >=18 and <65 Years and at Risk A B°Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BmmôBmÛèmRNA-1273-P301 mRNA-1273-P301-US381-2317US3812317US381USAB7YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV’DV®DV’Hr"U4DV®HrFø0DV®HrFø0.......DW]DV’DWoDWp.DV’DWoDWp.Chronic Lung Disease >=18 and <65 Years and at Risk A B°Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BmÛèBmIÜmRNA-1273-P301 mRNA-1273-P301-US381-2323US3812323US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWADV™Hr+™DV¼HrY¾üDV¼HrY¾üDW%HrãÏpDWAHs°DWAHs°.DW]DV™DW$DW%.DV™DW$DW%. >=18 and <65 Years and Not at RiskAB¢Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B4mRNA-1273-P301 mRNA-1273-P301-US381-2323US3812323US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWADV™Hr+™DV¼HrY¾üDV¼HrY¾üDW%HrãÏpDWAHs°DWAHs°.DW]DV™DW$DW%.DV™DW$DW%. >=18 and <65 Years and Not at RiskAB¢Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B4B4mômRNA-1273-P301 mRNA-1273-P301-US381-2323US3812323US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWADV™Hr+™DV¼HrY¾üDV¼HrY¾üDW%HrãÏpDWAHs°DWAHs°.DW]DV™DW$DW%.DV™DW$DW%. >=18 and <65 Years and Not at RiskAB¢Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B4môB4ÛæmRNA-1273-P301 mRNA-1273-P301-US381-2323US3812323US381USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWADV™Hr+™DV¼HrY¾üDV¼HrY¾üDW%HrãÏpDWAHs°DWAHs°.DW]DV™DW$DW%.DV™DW$DW%. >=18 and <65 Years and Not at RiskAB¢Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B4ÛæB4IÚmRNA-1273-P301 mRNA-1273-P301-US382-2048US3822048US382USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW9DVvHqý“ÀDV’Hr"c¼DV’Hr"c¼DWHrÚøPDW9HrþŒ DW9HrþŒ .DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBJmRNA-1273-P301 mRNA-1273-P301-US382-2048US3822048US382USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDW9DVvHqý“ÀDV’Hr"c¼DV’Hr"c¼DWHrÚøPDW9HrþŒ DW9HrþŒ .DW]DVvDWDW.DVvDWDW. >=18 and <65 Years and Not at RiskABÌMinority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBJBJmômRNA-1273-P301 mRNA-1273-P301-US382-2180US3822180US382USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW8DVHrû,DVžHr2&¼DVžHr2&¼DWHrØÐDW8HrüÝXDW8HrüÝX.DW]DVDWDW.DVDWDW. >=18 and <65 Years and Not at RiskABÀNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BWmRNA-1273-P301 mRNA-1273-P301-US382-2200US3822200US382USAB?YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVƒDW0DVƒHr=`DV¦Hr<¨äDV¦Hr<¨äDWHrÏ|DW0HròlˆDW0Hròlˆ.DW]DVƒDWDW.DVƒDWDW. Diabetes >=18 and <65 Years and at Risk A B¸Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B2mRNA-1273-P301 mRNA-1273-P301-US382-2244US3822244US382USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW,DV‡HrÍ4DV§Hr=æDV§Hr=æDWHrÈVŒDW,Hrí@ÈDW,Hrí@È.DW]DV‡DW DW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B[mRNA-1273-P301 mRNA-1273-P301-US382-2244US3822244US382USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW,DV‡HrÍ4DV§Hr=æDV§Hr=æDWHrÈVŒDW,Hrí@ÈDW,Hrí@È.DW]DV‡DW DW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B[B[mômRNA-1273-P301 mRNA-1273-P301-US382-2244US3822244US382USAB*YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‡DW,DV‡HrÍ4DV§Hr=æDV§Hr=æDWHrÈVŒDW,Hrí@ÈDW,Hrí@È.DW]DV‡DW DW.DV‡DWDW. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B[môB[ÛèmRNA-1273-P301 mRNA-1273-P301-US382-2304US3822304US382USAB>YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‹DW1DV‹HrÆDVHrE±´DVHrE±´DWHrÎÙäDW1Hró¦ÔDW1Hró¦Ô.DW]DV‹DWDW.DV‹DWDW. Diabetes >=18 and <65 Years and at Risk A B±Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BlmRNA-1273-P301 mRNA-1273-P301-US383-2012US3832012US383USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW8DVoHqôDVŠHr·dDVŠHr·dDWHrÖ¨àDW8Hrý|DW8Hrý|.DW]DVoDWDW.DVoDWDW. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B‰mRNA-1273-P301 mRNA-1273-P301-US383-2012US3832012US383USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW8DVoHqôDVŠHr·dDVŠHr·dDWHrÖ¨àDW8Hrý|DW8Hrý|.DW]DVoDWDW.DVoDWDW. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B‰B‰mðmRNA-1273-P301 mRNA-1273-P301-US383-2012US3832012US383USAB*YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVoDW8DVoHqôDVŠHr·dDVŠHr·dDWHrÖ¨àDW8Hrý|DW8Hrý|.DW]DVoDWDW.DVoDWDW. >=18 and <65 Years and Not at RiskABÔNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B‰mðB‰ÛèmRNA-1273-P301 mRNA-1273-P301-US383-2052US3832052US383USAB3YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW8DVrHq÷Ú4DVHr~´DVHr~´DWHrÏàDW8HrýAäDW8HrýAä.DW]DVrDWDW.DVrDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BˆmRNA-1273-P301 mRNA-1273-P301-US383-2052US3832052US383USAB3YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW8DVrHq÷Ú4DVHr~´DVHr~´DWHrÏàDW8HrýAäDW8HrýAä.DW]DVrDWDW.DVrDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BˆBˆmðmRNA-1273-P301 mRNA-1273-P301-US383-2052US3832052US383USAB3YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW8DVrHq÷Ú4DVHr~´DVHr~´DWHrÏàDW8HrýAäDW8HrýAä.DW]DVrDWDW.DVrDWDW. >=18 and <65 Years and Not at RiskABÏNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BˆmðBˆÛèmRNA-1273-P301 mRNA-1273-P301-US383-2059US3832059US383USABYEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVrDW8DVrHqø ¸DVŒHr+DVŒHr+DWHrÎ»¨DW8Hrüï DW8Hrüï .DW]DVrDWDW.DVrDWDW. >=18 and <65 Years and Not at RiskABÒNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BmRNA-1273-P301 mRNA-1273-P301-US383-2118US3832118US383USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW)DVuHqüDV‘Hr í4DV‘Hr í4DW HrÄFdDW)Hré(¨DW)Hré(¨.DW]DVuDWDW .DVuDWDW . Diabetes >=65 Years A0BÍNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB/mRNA-1273-P301 mRNA-1273-P301-US383-2118US3832118US383USABGYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW)DVuHqüDV‘Hr í4DV‘Hr í4DW HrÄFdDW)Hré(¨DW)Hré(¨.DW]DVuDWDW .DVuDWDW . Diabetes >=65 Years A0BÍNon-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB/B/mômRNA-1273-P301 mRNA-1273-P301-US383-2119US3832119US383USAB;YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVuDV‘DVuHqüÌDV‘Hr Ó¨DV‘Hr Ó¨.......DW]DVuDWDW.DVuDWDW. >=18 and <65 Years and Not at RiskABÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BvmRNA-1273-P301 mRNA-1273-P301-US383-2121US3832121US383USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW2DVuHqü-ÜDV‘Hr þÈDV‘Hr þÈDWHrÎá DW2HrõKLDW2HrõKL.DW]DVuDWDW.DVuDWDW. >=65 Years A0BÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBMmRNA-1273-P301 mRNA-1273-P301-US383-2121US3832121US383USABHYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVuDW2DVuHqü-ÜDV‘Hr þÈDV‘Hr þÈDWHrÎá DW2HrõKLDW2HrõKL.DW]DVuDWDW.DVuDWDW. >=65 Years A0BÍNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBMBMmômRNA-1273-P301 mRNA-1273-P301-US383-2155US3832155US383USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW3DVzHrn,DV—Hr(±,DV—Hr(±,DWHrÐ(DW3HröG¸DW3HröG¸.DW]DVzDWDW.DVzDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBmRNA-1273-P301 mRNA-1273-P301-US383-2155US3832155US383USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVzDW3DVzHrn,DV—Hr(±,DV—Hr(±,DWHrÐ(DW3HröG¸DW3HröG¸.DW]DVzDWDW.DVzDWDW. >=18 and <65 Years and Not at RiskABÇNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBBmômRNA-1273-P301 mRNA-1273-P301-US383-2274US3832274US383USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV«DVÈDV«HrC:ˆDVÈHri™0DVÈHri™0.......DW]DV«DWDW.DV«DWDW. Severe Obesity >=18 and <65 Years and at Risk A B–Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB[mRNA-1273-P301 mRNA-1273-P301-US383-2274US3832274US383USAB,YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DV«DVÈDV«HrC:ˆDVÈHri™0DVÈHri™0.......DW]DV«DWDW.DV«DWDW. Severe Obesity >=18 and <65 Years and at Risk A B–Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB[B[mômRNA-1273-P301 mRNA-1273-P301-US384-2039US3842039US384USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DWGDV Hr4¤xDVÃHrb¦HDVÃHrb¦HDW+Hrëð°DWGHs¿øDWGHs¿ø.DW]DV DWDW.DV DW*DW+. >=18 and <65 Years and Not at RiskAB›Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBZmRNA-1273-P301 mRNA-1273-P301-US384-2039US3842039US384USAB3YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DWGDV Hr4¤xDVÃHrb¦HDVÃHrb¦HDW+Hrëð°DWGHs¿øDWGHs¿ø.DW]DV DWDW.DV DW*DW+. >=18 and <65 Years and Not at RiskAB›Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBZBZmômRNA-1273-P301 mRNA-1273-P301-US384-2040US3842040US384USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DW6DV Hr4ÙpDV¼HrY†øDV¼HrY†øDWHrÎùDW6Hrúq¨DW6Hrúq¨.DW]DV DWDW.DV DWDW.Chronic Lung Disease Diabetes >=18 and <65 Years and at Risk A B¢Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B.mRNA-1273-P301 mRNA-1273-P301-US384-2040US3842040US384USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DW6DV Hr4ÙpDV¼HrY†øDV¼HrY†øDWHrÎùDW6Hrúq¨DW6Hrúq¨.DW]DV DWDW.DV DWDW.Chronic Lung Disease Diabetes >=18 and <65 Years and at Risk A B¢Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B.B.mômRNA-1273-P301 mRNA-1273-P301-US384-2040US3842040US384USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DW6DV Hr4ÙpDV¼HrY†øDV¼HrY†øDWHrÎùDW6Hrúq¨DW6Hrúq¨.DW]DV DWDW.DV DWDW.Chronic Lung Disease Diabetes >=18 and <65 Years and at Risk A B¢Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B.môB.ÛæmRNA-1273-P301 mRNA-1273-P301-US384-2040US3842040US384USAB1YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DW6DV Hr4ÙpDV¼HrY†øDV¼HrY†øDWHrÎùDW6Hrúq¨DW6Hrúq¨.DW]DV DWDW.DV DWDW.Chronic Lung Disease Diabetes >=18 and <65 Years and at Risk A B¢Minority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B.ÛæB.IÚmRNA-1273-P301 mRNA-1273-P301-US384-2057US3842057US384USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVµDWGDVµHrP”lDVÕHrz±èDVÕHrz±èDW+Hrëô¬DWGHsâlDWGHsâl.DW]DVµDW$DW%.DVµDW*DW+. >=18 and <65 Years and Not at RiskAB‰Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBKmRNA-1273-P301 mRNA-1273-P301-US384-2057US3842057US384USAB YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVµDWGDVµHrP”lDVÕHrz±èDVÕHrz±èDW+Hrëô¬DWGHsâlDWGHsâl.DW]DVµDW$DW%.DVµDW*DW+. >=18 and <65 Years and Not at RiskAB‰Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBKBKmômRNA-1273-P301 mRNA-1273-P301-US385-2019US3852019US385USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW:DVˆHrß¨DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BpmRNA-1273-P301 mRNA-1273-P301-US385-2019US3852019US385USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW:DVˆHrß¨DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BpBpmômRNA-1273-P301 mRNA-1273-P301-US385-2019US3852019US385USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVˆDW:DVˆHrß¨DV¦Hr=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BpmôBpÛèmRNA-1273-P301 mRNA-1273-P301-US385-2045US3852045US385USAB8YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW8DVŠHr–XDV¦Hr<üDV¦Hr<üDWHrÙ}DW8Hrüä$DW8Hrüä$.DW]DVŠDWDW.DVŠDWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A B¸Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB4mRNA-1273-P301 mRNA-1273-P301-US385-2045US3852045US385USAB8YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW8DVŠHr–XDV¦Hr<üDV¦Hr<üDWHrÙ}DW8Hrüä$DW8Hrüä$.DW]DVŠDWDW.DVŠDWDW.Chronic Lung Disease >=18 and <65 Years and at Risk A B¸Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB4B4mômRNA-1273-P301 mRNA-1273-P301-US385-2064US3852064US385USAB$YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV‹DV§DV‹HrDV§Hr=ðDV§Hr=ð.......DW]DV‹DVÿDWDWDV‹DVÿDWDW >=18 and <65 Years and Not at RiskABZNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B\mRNA-1273-P301 mRNA-1273-P301-US385-2070US3852070US385USAB+YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW:DVŽHrëÐDV§Hr=§äDV§Hr=§äDWHrÚ«4DW:Hrÿ‡ØDW:Hrÿ‡Ø.DW]DVŽDWDW.DVŽDWDW. >=18 and <65 Years and Not at RiskAB·Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B*mRNA-1273-P301 mRNA-1273-P301-US385-2086US3852086US385USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT REPORTED YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHrbüDVHrEáüDVHrEáüDW"HràDW?Hs;ðDW?Hs;ð.DW]DVDW!DW".DVDW!DW". >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB}mRNA-1273-P301 mRNA-1273-P301-US385-2086US3852086US385USAB'YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT REPORTED YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW?DVHrbüDVHrEáüDVHrEáüDW"HràDW?Hs;ðDW?Hs;ð.DW]DVDW!DW".DVDW!DW". >=18 and <65 Years and Not at RiskAB±Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB}B}mômRNA-1273-P301 mRNA-1273-P301-US385-2090US3852090US385USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW@DVHr¢€DVªHrAï\DVªHrAï\DW#HrágDDW@HspDW@Hsp.DW]DVDW"DW#.DVDW"DW#. >=18 and <65 Years and Not at RiskAB´Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B@mRNA-1273-P301 mRNA-1273-P301-US385-2090US3852090US385USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW@DVHr¢€DVªHrAï\DVªHrAï\DW#HrágDDW@HspDW@Hsp.DW]DVDW"DW#.DVDW"DW#. >=18 and <65 Years and Not at RiskAB´Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B@B@mômRNA-1273-P301 mRNA-1273-P301-US385-2090US3852090US385USAB%YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDW@DVHr¢€DVªHrAï\DVªHrAï\DW#HrágDDW@HspDW@Hsp.DW]DVDW"DW#.DVDW"DW#. >=18 and <65 Years and Not at RiskAB´Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B@môB@ÛèmRNA-1273-P301 mRNA-1273-P301-US385-2114US3852114US385USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWTDV’Hr",lDV²HrLADV²HrLADW:HrÿDWTHs!¹DWTHs!¹.DW]DV’DW9DW:.DV’DW9DW:. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBŒmRNA-1273-P301 mRNA-1273-P301-US385-2114US3852114US385USAB/YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV’DWTDV’Hr",lDV²HrLADV²HrLADW:HrÿDWTHs!¹DWTHs!¹.DW]DV’DW9DW:.DV’DW9DW:. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBŒBŒmðmRNA-1273-P301 mRNA-1273-P301-US385-2122US3852122US385USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW?DV–Hr'JDV±HrKÐDV±HrKÐDW$HrâohDW?Hs LDW?Hs L.DW]DV–DW#DW$.DV–DW#DW$. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BimRNA-1273-P301 mRNA-1273-P301-US385-2122US3852122US385USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW?DV–Hr'JDV±HrKÐDV±HrKÐDW$HrâohDW?Hs LDW?Hs L.DW]DV–DW#DW$.DV–DW#DW$. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BiBimômRNA-1273-P301 mRNA-1273-P301-US385-2122US3852122US385USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW?DV–Hr'JDV±HrKÐDV±HrKÐDW$HrâohDW?Hs LDW?Hs L.DW]DV–DW#DW$.DV–DW#DW$. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BimôBiÛèmRNA-1273-P301 mRNA-1273-P301-US385-2122US3852122US385USAB?YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW?DV–Hr'JDV±HrKÐDV±HrKÐDW$HrâohDW?Hs LDW?Hs L.DW]DV–DW#DW$.DV–DW#DW$. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BiÛèBiIÜmRNA-1273-P301 mRNA-1273-P301-US385-2147US3852147US385USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV—DV³DV—Hr(Û DV³HrM–ôDV³HrM–ô.......DW]DV—DW'DW(DW2DV—DW'DW(DW2 >=65 Years A0B€Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B=mRNA-1273-P301 mRNA-1273-P301-US385-2147US3852147US385USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV—DV³DV—Hr(Û DV³HrM–ôDV³HrM–ô.......DW]DV—DW'DW(DW2DV—DW'DW(DW2 >=65 Years A0B€Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B=B=mômRNA-1273-P301 mRNA-1273-P301-US385-2147US3852147US385USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV—DV³DV—Hr(Û DV³HrM–ôDV³HrM–ô.......DW]DV—DW'DW(DW2DV—DW'DW(DW2 >=65 Years A0B€Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B=môB=ÛæmRNA-1273-P301 mRNA-1273-P301-US385-2178US3852178US385USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWEDV™Hr+’HDVµHrPpDVµHrPpDW+HrëÉDWEHs ÷<DWEHs ÷<.DW]DV™DW*DW+.DV™DW*DW+. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B;mRNA-1273-P301 mRNA-1273-P301-US385-2178US3852178US385USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWEDV™Hr+’HDVµHrPpDVµHrPpDW+HrëÉDWEHs ÷<DWEHs ÷<.DW]DV™DW*DW+.DV™DW*DW+. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B;B;mômRNA-1273-P301 mRNA-1273-P301-US385-2178US3852178US385USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWEDV™Hr+’HDVµHrPpDVµHrPpDW+HrëÉDWEHs ÷<DWEHs ÷<.DW]DV™DW*DW+.DV™DW*DW+. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B;môB;ÛæmRNA-1273-P301 mRNA-1273-P301-US385-2178US3852178US385USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWEDV™Hr+’HDVµHrPpDVµHrPpDW+HrëÉDWEHs ÷<DWEHs ÷<.DW]DV™DW*DW+.DV™DW*DW+. >=18 and <65 Years and Not at RiskAB©Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B;ÛæB;IÚmRNA-1273-P301 mRNA-1273-P301-US386-2157US3862157US386USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DWNDV—Hr(ûxDV³HrMÖðDV³HrMÖðDWNHsêÄDWNHsêÄ...DW]DV—DWMDWN.DV—DWMDWN. >=18 and <65 Years and Not at RiskAB«Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BZmRNA-1273-P301 mRNA-1273-P301-US386-2157US3862157US386USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DWNDV—Hr(ûxDV³HrMÖðDV³HrMÖðDWNHsêÄDWNHsêÄ...DW]DV—DWMDWN.DV—DWMDWN. >=18 and <65 Years and Not at RiskAB«Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BZBZmômRNA-1273-P301 mRNA-1273-P301-US386-2157US3862157US386USAB&YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV—DWNDV—Hr(ûxDV³HrMÖðDV³HrMÖðDWNHsêÄDWNHsêÄ...DW]DV—DWMDWN.DV—DWMDWN. >=18 and <65 Years and Not at RiskAB«Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BZmôBZÛèmRNA-1273-P301 mRNA-1273-P301-US386-2169US3862169US386USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWADV™Hr+W8DV¸HrT[tDV¸HrT[tDW$HrâÑØDWAHs xDWAHs x.DW]DV™DW"DW#.DV™DW#DW$. >=18 and <65 Years and Not at RiskAB¦Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBlmRNA-1273-P301 mRNA-1273-P301-US386-2169US3862169US386USAB5YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV™DWADV™Hr+W8DV¸HrT[tDV¸HrT[tDW$HrâÑØDWAHs xDWAHs x.DW]DV™DW"DW#.DV™DW#DW$. >=18 and <65 Years and Not at RiskAB¦Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBlBlmômRNA-1273-P301 mRNA-1273-P301-US386-2196US3862196US386USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDWDDVžHr1î|DVºHrVÊlDVºHrVÊlDWDHsôDWDHsô...DW]DVžDWCDWD.DVžDWCDWD. >=65 Years A0B¤Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B`mRNA-1273-P301 mRNA-1273-P301-US387-2101US3872101US387USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWGDVvHqý^DV’Hr" DV’Hr" DW%HrãÔ˜DWGHs˜ÔDWGHs˜Ô.DW]DVvDW$DW%.DVvDW$DW%.Chronic Lung Disease >=65 Years A0BÌNon-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BvmRNA-1273-P301 mRNA-1273-P301-US387-2101US3872101US387USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWGDVvHqý^DV’Hr" DV’Hr" DW%HrãÔ˜DWGHs˜ÔDWGHs˜Ô.DW]DVvDW$DW%.DVvDW$DW%.Chronic Lung Disease >=65 Years A0BÌNon-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BvBvmômRNA-1273-P301 mRNA-1273-P301-US387-2101US3872101US387USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWGDVvHqý^DV’Hr" DV’Hr" DW%HrãÔ˜DWGHs˜ÔDWGHs˜Ô.DW]DVvDW$DW%.DVvDW$DW%.Chronic Lung Disease >=65 Years A0BÌNon-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BvmôBvÛèmRNA-1273-P301 mRNA-1273-P301-US387-2101US3872101US387USABIYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVvDWGDVvHqý^DV’Hr" DV’Hr" DW%HrãÔ˜DWGHs˜ÔDWGHs˜Ô.DW]DVvDW$DW%.DVvDW$DW%.Chronic Lung Disease >=65 Years A0BÌNon-minorityNon-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BvÛèBvIÜmRNA-1273-P301 mRNA-1273-P301-US387-2112US3872112US387USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDWFDVyHr%”DV–Hr'[°DV–Hr'[°DWFHs]\DWFHs]\...DW]DVyDW/DW0.DVyDWEDWF. >=65 Years A0BÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB…mRNA-1273-P301 mRNA-1273-P301-US387-2112US3872112US387USABFYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVyDWFDVyHr%”DV–Hr'[°DV–Hr'[°DWFHs]\DWFHs]\...DW]DVyDW/DW0.DVyDWEDWF. >=65 Years A0BÈNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB…B…mðmRNA-1273-P301 mRNA-1273-P301-US387-2205US3872205US387USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWNDV€Hr BŒDVŸHr30DVŸHr30DWNHsé˜DWNHsé˜...DW]DV€DWMDWN.DV€DWMDWN. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBˆmRNA-1273-P301 mRNA-1273-P301-US387-2205US3872205US387USAB8YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV€DWNDV€Hr BŒDVŸHr30DVŸHr30DWNHsé˜DWNHsé˜...DW]DV€DWMDWN.DV€DWMDWN. >=18 and <65 Years and Not at RiskAB¿Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBˆBˆmðmRNA-1273-P301 mRNA-1273-P301-US387-2223US3872223US387USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW+DV‚Hræ|DVžHr1Ã˜DVžHr1Ã˜DWHrÇpDW+HrëûðDW+Hrëûð.DW]DV‚DWDW.DV‚DWDW. Diabetes >=18 and <65 Years and at Risk A BÀMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B!mRNA-1273-P301 mRNA-1273-P301-US387-2223US3872223US387USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW+DV‚Hræ|DVžHr1Ã˜DVžHr1Ã˜DWHrÇpDW+HrëûðDW+Hrëûð.DW]DV‚DWDW.DV‚DWDW. Diabetes >=18 and <65 Years and at Risk A BÀMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B!B!mômRNA-1273-P301 mRNA-1273-P301-US387-2223US3872223US387USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW+DV‚Hræ|DVžHr1Ã˜DVžHr1Ã˜DWHrÇpDW+HrëûðDW+Hrëûð.DW]DV‚DWDW.DV‚DWDW. Diabetes >=18 and <65 Years and at Risk A BÀMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B!môB!ÛæmRNA-1273-P301 mRNA-1273-P301-US387-2223US3872223US387USAB0YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‚DW+DV‚Hræ|DVžHr1Ã˜DVžHr1Ã˜DWHrÇpDW+HrëûðDW+Hrëûð.DW]DV‚DWDW.DV‚DWDW. Diabetes >=18 and <65 Years and at Risk A BÀMinority Caucasian AAt Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B!ÛæB!IÚmRNA-1273-P301 mRNA-1273-P301-US387-2295US3872295US387USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV±DVˆHràDV±HrKJ4DV±HrKJ4.......DW]DVˆDWDW DW DVˆDWDW DW >=18 and <65 Years and Not at RiskAB]Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BomRNA-1273-P301 mRNA-1273-P301-US387-2295US3872295US387USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV±DVˆHràDV±HrKJ4DV±HrKJ4.......DW]DVˆDWDW DW DVˆDWDW DW >=18 and <65 Years and Not at RiskAB]Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BoBomômRNA-1273-P301 mRNA-1273-P301-US387-2295US3872295US387USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVˆDV±DVˆHràDV±HrKJ4DV±HrKJ4.......DW]DVˆDWDW DW DVˆDWDW DW >=18 and <65 Years and Not at RiskAB]Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BomôBoÛèmRNA-1273-P301 mRNA-1273-P301-US387-2317US3872317US387USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWKDV‰HrxàDV¥Hr;4<DV¥Hr;4<DW)HréM8DWKHs9LDWKHs9L.DW]DV‰DW(DW).DV‰DW(DW). >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BhmRNA-1273-P301 mRNA-1273-P301-US387-2317US3872317US387USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWKDV‰HrxàDV¥Hr;4<DV¥Hr;4<DW)HréM8DWKHs9LDWKHs9L.DW]DV‰DW(DW).DV‰DW(DW). >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BhBhmômRNA-1273-P301 mRNA-1273-P301-US387-2317US3872317US387USAB,YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DWKDV‰HrxàDV¥Hr;4<DV¥Hr;4<DW)HréM8DWKHs9LDWKHs9L.DW]DV‰DW(DW).DV‰DW(DW). >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BhmôBhÛèmRNA-1273-P301 mRNA-1273-P301-US387-2377US3872377US387USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHr³ÌDV±HrJßDV±HrJßDW@HsuDW@Hsu...DW]DVŽDW?DW@.DVŽDW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BUmRNA-1273-P301 mRNA-1273-P301-US387-2377US3872377US387USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHr³ÌDV±HrJßDV±HrJßDW@HsuDW@Hsu...DW]DVŽDW?DW@.DVŽDW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BUBUmômRNA-1273-P301 mRNA-1273-P301-US387-2377US3872377US387USAB$YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDW@DVŽHr³ÌDV±HrJßDV±HrJßDW@HsuDW@Hsu...DW]DVŽDW?DW@.DVŽDW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityNon-caucasianA Not At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BUmôBUÛèmRNA-1273-P301 mRNA-1273-P301-US387-2409US3872409US387USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDV«DVHr@ DV«HrCYðDV«HrCYð.......DW]DVDW*DW+.DVDW*DW+. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BbmRNA-1273-P301 mRNA-1273-P301-US387-2409US3872409US387USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDV«DVHr@ DV«HrCYðDV«HrCYð.......DW]DVDW*DW+.DVDW*DW+. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BbBbmômRNA-1273-P301 mRNA-1273-P301-US387-2409US3872409US387USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDV«DVHr@ DV«HrCYðDV«HrCYð.......DW]DVDW*DW+.DVDW*DW+. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BbmôBbÛèmRNA-1273-P301 mRNA-1273-P301-US387-2409US3872409US387USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDV«DVHr@ DV«HrCYðDV«HrCYð.......DW]DVDW*DW+.DVDW*DW+. >=18 and <65 Years and Not at RiskAB³Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BbÛèBbIÜmRNA-1273-P301 mRNA-1273-P301-US389-2017US3892017US389USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŽDV®DVŽHrË´DV®HrFá8DV®HrFá8.......DW]DVŽDWDW.DVŽDWDW. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianBQmRNA-1273-P301 mRNA-1273-P301-US389-2017US3892017US389USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVŽDV®DVŽHrË´DV®HrFá8DV®HrFá8.......DW]DVŽDWDW.DVŽDWDW. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianBQBQmômRNA-1273-P301 mRNA-1273-P301-US389-2059US3892059US389USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW*DV–Hr'o`DV±HrJè´DV±HrJè´DWHrÅ«”DW*HrêgàDW*Hrêgà.DW]DV–DW DW.DV–DW DW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BSmRNA-1273-P301 mRNA-1273-P301-US389-2059US3892059US389USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW*DV–Hr'o`DV±HrJè´DV±HrJè´DWHrÅ«”DW*HrêgàDW*Hrêgà.DW]DV–DW DW.DV–DW DW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BSBSmômRNA-1273-P301 mRNA-1273-P301-US389-2059US3892059US389USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW*DV–Hr'o`DV±HrJè´DV±HrJè´DWHrÅ«”DW*HrêgàDW*Hrêgà.DW]DV–DW DW.DV–DW DW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BSmôBSÛèmRNA-1273-P301 mRNA-1273-P301-US389-2059US3892059US389USAB'YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW*DV–Hr'o`DV±HrJè´DV±HrJè´DWHrÅ«”DW*HrêgàDW*Hrêgà.DW]DV–DW DW.DV–DW DW. >=18 and <65 Years and Not at RiskABMinority Caucasian ANot At RiskA Communities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BSÛèBSIÜmRNA-1273-P301 mRNA-1273-P301-US390-2015US3902015US390USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DWSDV–Hr'M(DV²HrL:pDV²HrL:pDW:Hrÿ»àDWSHs ‡0DWSHs ‡0.DW]DV–DW*DW+.DV–DW9DW:. Severe Obesity >=18 and <65 Years and at Risk A B¬Minority Non-caucasianA At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B2mRNA-1273-P301 mRNA-1273-P301-US390-2015US3902015US390USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DWSDV–Hr'M(DV²HrL:pDV²HrL:pDW:Hrÿ»àDWSHs ‡0DWSHs ‡0.DW]DV–DW*DW+.DV–DW9DW:. Severe Obesity >=18 and <65 Years and at Risk A B¬Minority Non-caucasianA At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B2B2mômRNA-1273-P301 mRNA-1273-P301-US390-2015US3902015US390USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DWSDV–Hr'M(DV²HrL:pDV²HrL:pDW:Hrÿ»àDWSHs ‡0DWSHs ‡0.DW]DV–DW*DW+.DV–DW9DW:. Severe Obesity >=18 and <65 Years and at Risk A B¬Minority Non-caucasianA At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B2môB2ÛæmRNA-1273-P301 mRNA-1273-P301-US390-2015US3902015US390USAB5YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DWSDV–Hr'M(DV²HrL:pDV²HrL:pDW:Hrÿ»àDWSHs ‡0DWSHs ‡0.DW]DV–DW*DW+.DV–DW9DW:. Severe Obesity >=18 and <65 Years and at Risk A B¬Minority Non-caucasianA At Risk ACommunities of ColorA YYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B2ÛæB2IÚmRNA-1273-P301 mRNA-1273-P301-US390-2132US3902132US390USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¼DWRDV¼HrYš¨DVØHr~yhDVØHr~yhDWRHs{ˆDWRHs{ˆ...DW]DV¼DW)DW*.DV¼DWQDWR. Significant Cardiac Disease Diabetes >=18 and <65 Years and at Risk A B†Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB1mRNA-1273-P301 mRNA-1273-P301-US390-2132US3902132US390USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¼DWRDV¼HrYš¨DVØHr~yhDVØHr~yhDWRHs{ˆDWRHs{ˆ...DW]DV¼DW)DW*.DV¼DWQDWR. Significant Cardiac Disease Diabetes >=18 and <65 Years and at Risk A B†Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB1B1mômRNA-1273-P301 mRNA-1273-P301-US391-2119US3912119US391USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW1DV–Hr'f<DV²HrL•ØDV²HrL•ØDWHrÐGüDW1Hróñ\DW1Hróñ\.DW]DV–DWDW.DV–DWDW. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B!mRNA-1273-P301 mRNA-1273-P301-US391-2119US3912119US391USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW1DV–Hr'f<DV²HrL•ØDV²HrL•ØDWHrÐGüDW1Hróñ\DW1Hróñ\.DW]DV–DWDW.DV–DWDW. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B!B!mômRNA-1273-P301 mRNA-1273-P301-US391-2119US3912119US391USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW1DV–Hr'f<DV²HrL•ØDV²HrL•ØDWHrÐGüDW1Hróñ\DW1Hróñ\.DW]DV–DWDW.DV–DWDW. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B!môB!ÛæmRNA-1273-P301 mRNA-1273-P301-US391-2119US3912119US391USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV–DW1DV–Hr'f<DV²HrL•ØDV²HrL•ØDWHrÐGüDW1Hróñ\DW1Hróñ\.DW]DV–DWDW.DV–DWDW. >=18 and <65 Years and Not at RiskAB¬Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B!ÛæB!IÚmRNA-1273-P301 mRNA-1273-P301-US392-2006US3922006US392USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVDVDVHrì,DVHr0ÎèDVHr0Îè.......DW]DVDW..DVDW.. >=18 and <65 Years and Not at RiskAB‚Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BšmRNA-1273-P301 mRNA-1273-P301-US392-2006US3922006US392USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVDVDVHrì,DVHr0ÎèDVHr0Îè.......DW]DVDW..DVDW.. >=18 and <65 Years and Not at RiskAB‚Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BšBšmðmRNA-1273-P301 mRNA-1273-P301-US392-2006US3922006US392USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVDVDVHrì,DVHr0ÎèDVHr0Îè.......DW]DVDW..DVDW.. >=18 and <65 Years and Not at RiskAB‚Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BšmðBšÛèmRNA-1273-P301 mRNA-1273-P301-US392-2060US3922060US392USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWFDVŽHrtDV®HrGDV®HrGDWFHsXDWFHsX...DW]DVŽDW0DW1.DVŽDWEDWF. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BwmRNA-1273-P301 mRNA-1273-P301-US392-2060US3922060US392USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWFDVŽHrtDV®HrGDV®HrGDWFHsXDWFHsX...DW]DVŽDW0DW1.DVŽDWEDWF. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BwBwmômRNA-1273-P301 mRNA-1273-P301-US392-2060US3922060US392USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWFDVŽHrtDV®HrGDV®HrGDWFHsXDWFHsX...DW]DVŽDW0DW1.DVŽDWEDWF. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BwmôBwÛèmRNA-1273-P301 mRNA-1273-P301-US392-2060US3922060US392USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWFDVŽHrtDV®HrGDV®HrGDWFHsXDWFHsX...DW]DVŽDW0DW1.DVŽDWEDWF. >=18 and <65 Years and Not at RiskAB°Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BwÛèBwIÜmRNA-1273-P301 mRNA-1273-P301-US392-2160US3922160US392USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¿DW\DV¿Hr]ªXDVßHr‡ÀTDVßHr‡ÀTDW@Hs¢ÄDW\Hs,hèDW\Hs,hè.DW]DV¿DW(DW).DV¿DW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BNmRNA-1273-P301 mRNA-1273-P301-US392-2160US3922160US392USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¿DW\DV¿Hr]ªXDVßHr‡ÀTDVßHr‡ÀTDW@Hs¢ÄDW\Hs,hèDW\Hs,hè.DW]DV¿DW(DW).DV¿DW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BNBNmômRNA-1273-P301 mRNA-1273-P301-US392-2160US3922160US392USAB#YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¿DW\DV¿Hr]ªXDVßHr‡ÀTDVßHr‡ÀTDW@Hs¢ÄDW\Hs,hèDW\Hs,hè.DW]DV¿DW(DW).DV¿DW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BNmôBNÛèmRNA-1273-P301 mRNA-1273-P301-US392-2164US3922164US392USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVÀDVãDVÀHr^ÒÔDVãHrŒáÄDVãHrŒáÄ.......DW]DVÀDW>DW?.DVÀDW>DW?. >=18 and <65 Years and Not at RiskAB{Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BEmRNA-1273-P301 mRNA-1273-P301-US392-2164US3922164US392USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVÀDVãDVÀHr^ÒÔDVãHrŒáÄDVãHrŒáÄ.......DW]DVÀDW>DW?.DVÀDW>DW?. >=18 and <65 Years and Not at RiskAB{Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BEBEmômRNA-1273-P301 mRNA-1273-P301-US392-2164US3922164US392USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVÀDVãDVÀHr^ÒÔDVãHrŒáÄDVãHrŒáÄ.......DW]DVÀDW>DW?.DVÀDW>DW?. >=18 and <65 Years and Not at RiskAB{Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BEmôBEÛèmRNA-1273-P301 mRNA-1273-P301-US392-2164US3922164US392USAB6YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADVÀDVãDVÀHr^ÒÔDVãHrŒáÄDVãHrŒáÄ.......DW]DVÀDW>DW?.DVÀDW>DW?. >=18 and <65 Years and Not at RiskAB{Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BEÛèBEIÜmRNA-1273-P301 mRNA-1273-P301-US393-2049US3932049US393USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWTDVHrìDV¬HrDCœDV¬HrDCœDW/Hrñ$,DWTHs"ˆDWTHs"ˆ.DW]DVDW.DW/.DVDW.DW/. >=65 Years A0B²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BqmRNA-1273-P301 mRNA-1273-P301-US393-2049US3932049US393USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWTDVHrìDV¬HrDCœDV¬HrDCœDW/Hrñ$,DWTHs"ˆDWTHs"ˆ.DW]DVDW.DW/.DVDW.DW/. >=65 Years A0B²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BqBqmômRNA-1273-P301 mRNA-1273-P301-US393-2049US3932049US393USABAYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWTDVHrìDV¬HrDCœDV¬HrDCœDW/Hrñ$,DWTHs"ˆDWTHs"ˆ.DW]DVDW.DW/.DVDW.DW/. >=65 Years A0B²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BqmôBqÛèmRNA-1273-P301 mRNA-1273-P301-US393-2050US3932050US393USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDV¬DVHr"˜DV¬HrD[üDV¬HrD[ü.......DW]DVDW?DW@.DVDW?DW@. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B–mRNA-1273-P301 mRNA-1273-P301-US393-2050US3932050US393USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDV¬DVHr"˜DV¬HrD[üDV¬HrD[ü.......DW]DVDW?DW@.DVDW?DW@. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B–B–mðmRNA-1273-P301 mRNA-1273-P301-US393-2050US3932050US393USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativemRNA-1273A mRNA-1273A . .mRNA-1273 A0mRNA-1273 A0DVDV¬DVHr"˜DV¬HrD[üDV¬HrD[ü.......DW]DVDW?DW@.DVDW?DW@. >=18 and <65 Years and Not at RiskAB²Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B–mðB–ÛèmRNA-1273-P301 mRNA-1273-P301-US393-2100US3932100US393USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWGDV˜Hr*lDV³HrM·LDV³HrM·LDWGHs»DWGHs»...DW]DV˜DWFDWG.DV˜DWFDWG. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B0mRNA-1273-P301 mRNA-1273-P301-US393-2100US3932100US393USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWGDV˜Hr*lDV³HrM·LDV³HrM·LDWGHs»DWGHs»...DW]DV˜DWFDWG.DV˜DWFDWG. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B0B0mômRNA-1273-P301 mRNA-1273-P301-US393-2100US3932100US393USAB#YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV˜DWGDV˜Hr*lDV³HrM·LDV³HrM·LDWGHs»DWGHs»...DW]DV˜DWFDWG.DV˜DWFDWG. >=18 and <65 Years and Not at RiskAB«Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B0môB0ÛæmRNA-1273-P301 mRNA-1273-P301-US393-2230US3932230US393USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYNNNYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV³DVÍDV³HrMÖxDVÍHroËpDVÍHroËp.......DW]DV³DWtDWu.DV³DWtDWu. >=18 and <65 Years and Not at RiskAB‘Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score B[mRNA-1273-P301 mRNA-1273-P301-US393-2230US3932230US393USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYNNNYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV³DVÍDV³HrMÖxDVÍHroËpDVÍHroËp.......DW]DV³DWtDWu.DV³DWtDWu. >=18 and <65 Years and Not at RiskAB‘Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score B[B[mômRNA-1273-P301 mRNA-1273-P301-US393-2230US3932230US393USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYNNNYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV³DVÍDV³HrMÖxDVÍHroËpDVÍHroËp.......DW]DV³DWtDWu.DV³DWtDWu. >=18 and <65 Years and Not at RiskAB‘Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score B[môB[ÛèmRNA-1273-P301 mRNA-1273-P301-US393-2230US3932230US393USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE HISPANIC OR LATINO YYYNNNYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV³DVÍDV³HrMÖxDVÍHroËpDVÍHroËp.......DW]DV³DWtDWu.DV³DWtDWu. >=18 and <65 Years and Not at RiskAB‘Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score B[ÛèB[IÜmRNA-1273-P301 mRNA-1273-P301-US393-2292US3932292US393USAB YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¿DWZDV¿Hr]fØDVØHr~@°DVØHr~@°DW=HsˆÄDWZHs)¶pDWZHs)¶p.DW]DV¿DW1DW2.DV¿DW<DW=. Severe Obesity >=18 and <65 Years and at Risk A B†Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BXmRNA-1273-P301 mRNA-1273-P301-US393-2304US3932304US393USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWYDVÁHr`|DVâHr‹g@DVâHr‹g@DW=Hs¡œDWYHs(UðDWYHs(Uð.DW]DVÁDW<DW=.DVÁDW<DW=. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B/mRNA-1273-P301 mRNA-1273-P301-US393-2304US3932304US393USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWYDVÁHr`|DVâHr‹g@DVâHr‹g@DW=Hs¡œDWYHs(UðDWYHs(Uð.DW]DVÁDW<DW=.DVÁDW<DW=. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B/B/mômRNA-1273-P301 mRNA-1273-P301-US393-2304US3932304US393USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÁDWYDVÁHr`|DVâHr‹g@DVâHr‹g@DW=Hs¡œDWYHs(UðDWYHs(Uð.DW]DVÁDW<DW=.DVÁDW<DW=. >=18 and <65 Years and Not at RiskAB|Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B/môB/ÛæmRNA-1273-P301 mRNA-1273-P301-US395-2154US3952154US395USAB@YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV§DW7DV§Hr=ÚüDVÆHrf²8DVÆHrf²8DW7HrûÃ DW7HrûÃ ...DW]DV§DW6DW7.DV§DW6DW7. >=18 and <65 Years and Not at RiskAB˜Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B7mRNA-1273-P301 mRNA-1273-P301-US396-2016US3962016US396USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWEDV„Hrà4DV¦Hr<¼ÐDV¦Hr<¼ÐDW)HréqDWEHsHÌDWEHsHÌ.DW]DV„DW(DW).DV„DW(DW). >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BpmRNA-1273-P301 mRNA-1273-P301-US396-2016US3962016US396USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWEDV„Hrà4DV¦Hr<¼ÐDV¦Hr<¼ÐDW)HréqDWEHsHÌDWEHsHÌ.DW]DV„DW(DW).DV„DW(DW). >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BpBpmômRNA-1273-P301 mRNA-1273-P301-US396-2016US3962016US396USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWEDV„Hrà4DV¦Hr<¼ÐDV¦Hr<¼ÐDW)HréqDWEHsHÌDWEHsHÌ.DW]DV„DW(DW).DV„DW(DW). >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BpmôBpÛèmRNA-1273-P301 mRNA-1273-P301-US396-2016US3962016US396USAB4YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV„DWEDV„Hrà4DV¦Hr<¼ÐDV¦Hr<¼ÐDW)HréqDWEHsHÌDWEHsHÌ.DW]DV„DW(DW).DV„DW(DW). >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYYTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BpÛèBpIÜmRNA-1273-P301 mRNA-1273-P301-US396-2037US3962037US396USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWFDVŽHrÄèDV«HrCDV«HrCDW,Hrí °DWFHsH€DWFHsH€.DW]DVŽDW+DW,.DVŽDW+DW,. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B³Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BmRNA-1273-P301 mRNA-1273-P301-US396-2037US3962037US396USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWFDVŽHrÄèDV«HrCDV«HrCDW,Hrí °DWFHsH€DWFHsH€.DW]DVŽDW+DW,.DVŽDW+DW,. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B³Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BBmðmRNA-1273-P301 mRNA-1273-P301-US396-2037US3962037US396USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWFDVŽHrÄèDV«HrCDV«HrCDW,Hrí °DWFHsH€DWFHsH€.DW]DVŽDW+DW,.DVŽDW+DW,. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B³Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BmðBÛèmRNA-1273-P301 mRNA-1273-P301-US396-2037US3962037US396USAB/YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWFDVŽHrÄèDV«HrCDV«HrCDW,Hrí °DWFHsH€DWFHsH€.DW]DVŽDW+DW,.DVŽDW+DW,. Severe ObesityDiabetes >=18 and <65 Years and at Risk A B³Non-minorityCaucasian AAt Risk AWhite AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BÛèBIØmRNA-1273-P301 mRNA-1273-P301-US396-2041US3962041US396USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYYYYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWLDVŽHrâèDVªHrA¸DVªHrA¸DW)HréaØDWLHslDWLHsl.DW]DVŽDW(DW).DVŽDW(DW). >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B\mRNA-1273-P301 mRNA-1273-P301-US396-2041US3962041US396USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYYYYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWLDVŽHrâèDVªHrA¸DVªHrA¸DW)HréaØDWLHslDWLHsl.DW]DVŽDW(DW).DVŽDW(DW). >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B\B\mômRNA-1273-P301 mRNA-1273-P301-US396-2041US3962041US396USAB9YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYYYYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŽDWLDVŽHrâèDVªHrA¸DVªHrA¸DW)HréaØDWLHslDWLHsl.DW]DVŽDW(DW).DVŽDW(DW). >=18 and <65 Years and Not at RiskAB´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B\môB\ÛèmRNA-1273-P301 mRNA-1273-P301-US396-2056US3962056US396USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWGDVHr¤$DVªHrA®4DVªHrA®4DWGHsçDWGHsç...DW]DVDWFDWG.DVDWFDWG. >=65 Years A0B´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BdmRNA-1273-P301 mRNA-1273-P301-US396-2056US3962056US396USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWGDVHr¤$DVªHrA®4DVªHrA®4DWGHsçDWGHsç...DW]DVDWFDWG.DVDWFDWG. >=65 Years A0B´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BdBdmômRNA-1273-P301 mRNA-1273-P301-US396-2056US3962056US396USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWGDVHr¤$DVªHrA®4DVªHrA®4DWGHsçDWGHsç...DW]DVDWFDWG.DVDWFDWG. >=65 Years A0B´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BdmôBdÛèmRNA-1273-P301 mRNA-1273-P301-US396-2056US3962056US396USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVDWGDVHr¤$DVªHrA®4DVªHrA®4DWGHsçDWGHsç...DW]DVDWFDWG.DVDWFDWG. >=65 Years A0B´Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BdÛèBdIÜmRNA-1273-P301 mRNA-1273-P301-US396-2065US3962065US396USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW@DV‘Hr Ù„DV±HrK´DV±HrK´DW@Hs„LDW@Hs„L...DW]DV‘DW?DW@.DV‘DW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BnmRNA-1273-P301 mRNA-1273-P301-US396-2065US3962065US396USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW@DV‘Hr Ù„DV±HrK´DV±HrK´DW@Hs„LDW@Hs„L...DW]DV‘DW?DW@.DV‘DW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BnBnmômRNA-1273-P301 mRNA-1273-P301-US396-2065US3962065US396USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW@DV‘Hr Ù„DV±HrK´DV±HrK´DW@Hs„LDW@Hs„L...DW]DV‘DW?DW@.DV‘DW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BnmôBnÛèmRNA-1273-P301 mRNA-1273-P301-US396-2065US3962065US396USAB6YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW@DV‘Hr Ù„DV±HrK´DV±HrK´DW@Hs„LDW@Hs„L...DW]DV‘DW?DW@.DV‘DW?DW@. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BnÛèBnIÜmRNA-1273-P301 mRNA-1273-P301-US396-2066US3962066US396USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW]DV‘Hr ëDVHrE¼ôDVHrE¼ôDWAHsÕÌDW]Hs-½ìDW]Hs-½ì.DW]DV‘DW@DWA.DV‘DW@DWA. Significant Cardiac Disease >=18 and <65 Years and at Risk A B±Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BŠmRNA-1273-P301 mRNA-1273-P301-US396-2066US3962066US396USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW]DV‘Hr ëDVHrE¼ôDVHrE¼ôDWAHsÕÌDW]Hs-½ìDW]Hs-½ì.DW]DV‘DW@DWA.DV‘DW@DWA. Significant Cardiac Disease >=18 and <65 Years and at Risk A B±Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BŠBŠmðmRNA-1273-P301 mRNA-1273-P301-US396-2066US3962066US396USAB<YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‘DW]DV‘Hr ëDVHrE¼ôDVHrE¼ôDWAHsÕÌDW]Hs-½ìDW]Hs-½ì.DW]DV‘DW@DWA.DV‘DW@DWA. Significant Cardiac Disease >=18 and <65 Years and at Risk A B±Non-minorityCaucasian AAt Risk AWhite AYYTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BŠmðBŠÛèmRNA-1273-P301 mRNA-1273-P301-US396-2113US3962113US396USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAFWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVÀDW@DVÀHr^®DDVÝHr„Î”DVÝHr„Î”DW%HrãÃ¸DW@HsRœDW@HsRœ.DW]DVÀDW$DW%.DVÀDW$DW%. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B"mRNA-1273-P301 mRNA-1273-P301-US397-2041US3972041US397USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWGDVŠHr•àDV¦Hr<\ôDV¦Hr<\ôDW+Hrë¯LDWGHsdDWGHsd.DW]DVŠDW*DW+.DVŠDW*DW+. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BFmRNA-1273-P301 mRNA-1273-P301-US397-2041US3972041US397USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWGDVŠHr•àDV¦Hr<\ôDV¦Hr<\ôDW+Hrë¯LDWGHsdDWGHsd.DW]DVŠDW*DW+.DVŠDW*DW+. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BFBFmômRNA-1273-P301 mRNA-1273-P301-US397-2041US3972041US397USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDWGDVŠHr•àDV¦Hr<\ôDV¦Hr<\ôDW+Hrë¯LDWGHsdDWGHsd.DW]DVŠDW*DW+.DVŠDW*DW+. >=18 and <65 Years and Not at RiskAB¸Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BFmôBFÛèmRNA-1273-P301 mRNA-1273-P301-US397-2106US3972106US397USAB)YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVžDW@DVžHr1þäDV¿Hr]ˆ\DV¿Hr]ˆ\DW$Hrâ²¬DW@Hs}€DW@Hs}€.DW]DVžDWDW.DVžDW#DW$. >=18 and <65 Years and Not at RiskABŸNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 BNmRNA-1273-P301 mRNA-1273-P301-US397-2149US3972149US397USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWUDVœHr/2,DV¼HrY”DV¼HrY”DW9Hrþ1lDWUHs#^°DWUHs#^°.DW]DVœDW8DW9.DVœDW8DW9. >=18 and <65 Years and Not at RiskAB¢Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB'mRNA-1273-P301 mRNA-1273-P301-US397-2149US3972149US397USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <=25 YearsAMWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVœDWUDVœHr/2,DV¼HrY”DV¼HrY”DW9Hrþ1lDWUHs#^°DWUHs#^°.DW]DVœDW8DW9.DVœDW8DW9. >=18 and <65 Years and Not at RiskAB¢Minority Caucasian ANot At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB'B'mômRNA-1273-P301 mRNA-1273-P301-US397-2196US3972196US397USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DWGDV Hr4Å„DV»HrXX DV»HrXX DW+HrëÌÔDWGHsé8DWGHsé8.DW]DV DW*DW+.DV DW*DW+. >=18 and <65 Years and Not at RiskAB£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3BJmRNA-1273-P301 mRNA-1273-P301-US397-2196US3972196US397USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DWGDV Hr4Å„DV»HrXX DV»HrXX DW+HrëÌÔDWGHsé8DWGHsé8.DW]DV DW*DW+.DV DW*DW+. >=18 and <65 Years and Not at RiskAB£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3BJBJmômRNA-1273-P301 mRNA-1273-P301-US397-2196US3972196US397USAB7YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV DWGDV Hr4Å„DV»HrXX DV»HrXX DW+HrëÌÔDWGHsé8DWGHsé8.DW]DV DW*DW+.DV DW*DW+. >=18 and <65 Years and Not at RiskAB£Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3BJmôBJÛèmRNA-1273-P301 mRNA-1273-P301-US398-2017US3982017US398USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW8DV‰Hrs¸DV¥Hr;4ðDV¥Hr;4ðDWHrÑpðDW8HrüþdDW8Hrüþd.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB:mRNA-1273-P301 mRNA-1273-P301-US398-2017US3982017US398USAB>YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV‰DW8DV‰Hrs¸DV¥Hr;4ðDV¥Hr;4ðDWHrÑpðDW8HrüþdDW8Hrüþd.DW]DV‰DWDW.DV‰DWDW. >=18 and <65 Years and Not at RiskAB¹Non-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB:B:mômRNA-1273-P301 mRNA-1273-P301-US398-2025US3982025US398USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW\DVŠHr¼PDV¦Hr<‰@DV¦Hr<‰@DW;Hs DW\Hs,qÐDW\Hs,qÐ.DW]DVŠDW0DW1.DVŠDW:DW;. Severe Obesity >=18 and <65 Years and at Risk A B¸Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BamRNA-1273-P301 mRNA-1273-P301-US398-2025US3982025US398USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW\DVŠHr¼PDV¦Hr<‰@DV¦Hr<‰@DW;Hs DW\Hs,qÐDW\Hs,qÐ.DW]DVŠDW0DW1.DVŠDW:DW;. Severe Obesity >=18 and <65 Years and at Risk A B¸Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BaBamômRNA-1273-P301 mRNA-1273-P301-US398-2025US3982025US398USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW\DVŠHr¼PDV¦Hr<‰@DV¦Hr<‰@DW;Hs DW\Hs,qÐDW\Hs,qÐ.DW]DVŠDW0DW1.DVŠDW:DW;. Severe Obesity >=18 and <65 Years and at Risk A B¸Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BamôBaÛèmRNA-1273-P301 mRNA-1273-P301-US398-2025US3982025US398USAB:YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DVŠDW\DVŠHr¼PDV¦Hr<‰@DV¦Hr<‰@DW;Hs DW\Hs,qÐDW\Hs,qÐ.DW]DVŠDW0DW1.DVŠDW:DW;. Severe Obesity >=18 and <65 Years and at Risk A B¸Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BaÛèBaIÜmRNA-1273-P301 mRNA-1273-P301-US398-2256US3982256US398USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV¬DVÈDV¬HrD4DVÈHrijDVÈHrij.......DW]DV¬DW3DW4DW4DV¬DW3DW4DW4 >=18 and <65 Years and Not at RiskABmMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ1 <= Total COVID-19 Symptoms Score < MedianB8mRNA-1273-P301 mRNA-1273-P301-US398-2256US3982256US398USAB.YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYNNNegativeNegativeNegativePlacebo APlacebo A . .Placebo APlacebo ADV¬DVÈDV¬HrD4DVÈHrijDVÈHrij.......DW]DV¬DW3DW4DW4DV¬DW3DW4DW4 >=18 and <65 Years and Not at RiskABmMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q1 <= Total COVID-19 Symptoms Score < MedianB8B8mômRNA-1273-P301 mRNA-1273-P301-US399-2010US3992010US399USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¡DWODV¡Hr5æ¼DVÁHr`ÀDVÁHr`ÀDW0HròVøDWOHs.pDWOHs.p.DW]DV¡DW/DW0.DV¡DW/DW0. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B6mRNA-1273-P301 mRNA-1273-P301-US399-2010US3992010US399USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¡DWODV¡Hr5æ¼DVÁHr`ÀDVÁHr`ÀDW0HròVøDWOHs.pDWOHs.p.DW]DV¡DW/DW0.DV¡DW/DW0. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B6B6mômRNA-1273-P301 mRNA-1273-P301-US399-2010US3992010US399USAB(YEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¡DWODV¡Hr5æ¼DVÁHr`ÀDVÁHr`ÀDW0HròVøDWOHs.pDWOHs.p.DW]DV¡DW/DW0.DV¡DW/DW0. >=18 and <65 Years and Not at RiskABMinority Non-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B6môB6ÛæmRNA-1273-P301 mRNA-1273-P301-US399-2028US3992028US399USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DWODV¦Hr<•¬DVÈHric„DVÈHric„DWOHsdXDWOHsdX...DW]DV¦DWNDWO.DV¦DWNDWO. Diabetes >=65 Years A0B–Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAQ3 <= Total COVID-19 Symptoms Score BNmRNA-1273-P301 mRNA-1273-P301-US399-2028US3992028US399USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DWODV¦Hr<•¬DVÈHric„DVÈHric„DWOHsdXDWOHsdX...DW]DV¦DWNDWO.DV¦DWNDWO. Diabetes >=65 Years A0B–Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Q3 <= Total COVID-19 Symptoms Score BNBNmômRNA-1273-P301 mRNA-1273-P301-US399-2028US3992028US399USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DWODV¦Hr<•¬DVÈHric„DVÈHric„DWOHsdXDWOHsdX...DW]DV¦DWNDWO.DV¦DWNDWO. Diabetes >=65 Years A0B–Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Q3 <= Total COVID-19 Symptoms Score BNmôBNÛèmRNA-1273-P301 mRNA-1273-P301-US399-2028US3992028US399USABDYEARS>=65 Years A0>=65 Years A >=65 and <75 YearsA >=65 and <75 YearsA .FBLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYNNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¦DWODV¦Hr<•¬DVÈHric„DVÈHric„DWOHsdXDWOHsdX...DW]DV¦DWNDWO.DV¦DWNDWO. Diabetes >=65 Years A0B–Minority Non-caucasianA At Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA@Q3 <= Total COVID-19 Symptoms Score BNÛèBNIÜmRNA-1273-P301 mRNA-1273-P301-US399-2039US3992039US399USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV¨DWODV¨Hr?.˜DVÎHrq=DVÎHrq=DW2Hrõ(œDWOHsKDDWOHsKD.DW]DV¨DW1DW2.DV¨DW1DW2. >=18 and <65 Years and Not at RiskABNon-minorityCaucasian ANot At RiskA White AYNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B<mRNA-1273-P301 mRNA-1273-P301-US399-2076US3992076US399USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DWSDV´HrOÔDVÏHrrvàDVÏHrrvàDW2Hrôÿ\DWSHs ™<DWSHs ™<.DW]DV´DW1DW2.DV´DW1DW2. Human Immunodeficiency Virus Infection>=18 and <65 Years and at Risk A BMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREAMedian <= Total COVID-19 Symptoms Score < Q3B/mRNA-1273-P301 mRNA-1273-P301-US399-2076US3992076US399USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DWSDV´HrOÔDVÏHrrvàDVÏHrrvàDW2Hrôÿ\DWSHs ™<DWSHs ™<.DW]DV´DW1DW2.DV´DW1DW2. Human Immunodeficiency Virus Infection>=18 and <65 Years and at Risk A BMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA Median <= Total COVID-19 Symptoms Score < Q3B/B/mômRNA-1273-P301 mRNA-1273-P301-US399-2076US3992076US399USAB(YEARS>=18 and <65 Years and at Risk A >=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MWHITE HISPANIC OR LATINO YYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DWSDV´HrOÔDVÏHrrvàDVÏHrrvàDW2Hrôÿ\DWSHs ™<DWSHs ™<.DW]DV´DW1DW2.DV´DW1DW2. Human Immunodeficiency Virus Infection>=18 and <65 Years and at Risk A BMinority Caucasian AAt Risk ACommunities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0Median <= Total COVID-19 Symptoms Score < Q3B/môB/ÛæmRNA-1273-P301 mRNA-1273-P301-US399-2077US3992077US399USABYEARS>=18 and <65 Years and Not at RiskA>=18 and <65 YearsA>=18 and <65 YearsA>=18 and <65 YearsA>=26 and <=50 YearsA MASIAN NOT HISPANIC OR LATINOYYYYYYYYNNYYYYYNegativeNegativeNegativePlacebo APlacebo AmRNA-1273A mRNA-1273A Placebo-mRNA-1273A Placebo-mRNA-1273A DV´DWODV´HrO˜DVÕHrz±¬DVÕHrz±¬DW2HrõôDWOHsT,DWOHsT,.DW]DV´DW1DW2.DV´DW1DW2. >=18 and <65 Years and Not at RiskAB‰Non-minorityNon-caucasianA Not At RiskA Communities of ColorA YNTotal COVID-19 Symptoms ScoreTOTSCOREA0 < Total COVID-19 Symptoms Score < Q1 B2