HEADER RECORD*******LIBRARY HEADER RECORD!!!!!!!000000000000000000000000000000 SAS SAS SASLIB 9.4 Linux 18NOV21:22:15:3218NOV21:22:15:32 HEADER RECORD*******MEMBER HEADER RECORD!!!!!!!000000000000000001600000000140 HEADER RECORD*******DSCRPTR HEADER RECORD!!!!!!!000000000000000000000000000000 SAS ADDS SASDATA 9.4 Linux 18NOV21:22:15:3218NOV21:22:15:32 HEADER RECORD*******NAMESTR HEADER RECORD!!!!!!!000000010200000000000000000000 STUDYID Study Identifier USUBJID Unique Subject Identifier SUBJID Subject Identifier for the Study SITEID Study Site Identifier &ADT Analysis Date DATE *ASTDT Analysis Start Date DATE 2ASTDY Analysis Start Relative Day :DSPHASE Disposition Phase B DSPHASENDisposition Phase Code (N) V DSCAT Category for Disposition Event ^$DSDECOD Standardized Disposition Term oDSDECODNStandardized Disposition Term (N) “d DSTERM Reported Term for the Disposition Event ›M1PD2DT 1 Month Post Dose 2 Visit Date DATE ÿM6PD2DT 6 Months Post Dose 2 Visit Date DATE M1PX2DT 1 Month Post Dose 4 Visit Date DATE M1P2CUT 1 Month PD2 Cutoff Date for Disposition DATE M1P2EXC Excluded from 1 Month Post Dose 2 AGE Age AGEU Age Units (SEX Sex -SEXN Sex (N) .)RACE Race 6RACEN Race (N) _)ARACE Analysis Race gARACEN Analysis Race (N) RANDFL Randomized Population Flag ˜SAFFL Safety Population Flag ™ARM Description of Planned Arm š ARMCD Planned Arm Code µACTARM Description of Actual Arm ¾ ACTARMCDActual Arm Code Ù!TRTSDT Date of First Exposure to Treatment DATE â"TRTSTM Time of First Exposure to Treatment TIME ê#TRTSDTM Datetime of First Exposure to Treatment DATETIME ò$TRTEDT Date of Last Exposure to Treatment DATE ú%TRTETM Time of Last Exposure to Treatment TIME &TRTEDTM Datetime of Last Exposure to Treatment DATETIME &'TRTSEQP Planned Sequence of Treatments &(TRTSEQA Actual Sequence of Treatments 8)AGEGR1 Pooled Age Group 1 ^*AGEGR1N Pooled Age Group 1 (N) i+COHORT Cohort Group q,COHORTN Cohort Group (N) r-DOSALVL Actual Dosing Level z.DOSALVLNActual Dosing Level (N) {/DOSPLVL Planned Dosing Level ƒ0DOSPLVLNPlanned Dosing Level (N) „1VAX101DTVaccination Date 01 DATE Œ2VAX102DTVaccination Date 02 DATE ”3VAX10UDTVaccination Date Unplanned DATE œ4VAX201DTVaccination Date 03 DATE ¤5VAX202DTVaccination Date 04 DATE ¬6VAX20UDTVaccination Date Unplanned in Period 02 DATE ´7UNBLNDDTTreatment Unblinded Date DATE ¼$8VAX101 Vaccination 01 Ä$9VAX102 Vaccination 02 è$:VAX10U Vaccination Unplanned $;VAX201 Vaccination 03 0$TRT01A Actual Treatment for Period 01 y?TRT01AN Actual Treatment for Period 01 (N) ”@TRT02A Actual Treatment for Period 02 œATRT02AN Actual Treatment for Period 02 (N) ·BTRT01P Planned Treatment for Period 01 ¿CTRT01PN Planned Treatment for Period 01 (N) ÚDTRT02P Planned Treatment for Period 02 âETRT02PN Planned Treatment for Period 02 (N) ýFTR01SDT Date of First Exposure in Period 01 DATE GTR01STM Time of First Exposure in Period 01 TIME HTR01SDTMDatetime of First Exposure in Period 01 DATETIME ITR01EDT Date of Last Exposure in Period 01 DATE JTR01ETM Time of Last Exposure in Period 01 TIME %KTR01EDTMDatetime of Last Exposure in Period 01 DATETIME -LTR02SDT Date of First Exposure in Period 02 DATE 5MTR02STM Time of First Exposure in Period 02 TIME =NTR02SDTMDatetime of First Exposure in Period 02 DATETIME EOTR02EDT Date of Last Exposure in Period 02 DATE MPTR02ETM Time of Last Exposure in Period 02 TIME UQTR02EDTMDatetime of Last Exposure in Period 02 DATETIME ]RPHASE Study Phase eSPHASEN Study Phase (N) lTEOSDCDT End Of Study Discontinuation Date DATE tUEOTDCDT End Of Treatment Discontinuation Date DATE |VBLDV6DT Blood Sample Date 1 Month after Vax 2 DATE „WBLDV7DT Blood Sample Date 6 Months after Vax 2 DATE ŒXAGEGR4 Pooled Age Group 4 ”YAGEGR4N Pooled Age Group 4 (N) ŸZPEDIMMFLPop for Non-inferiority Assessement §[PEDREAFLPhase 2/3 Pop for 12-25 Reacto Subset ¨\HIVFL HIV Positive Subjects Flag ©]DS3KFL FU to 6MPD2 ª^EOTXDCDTEnd Of Open Label Treatment D/C Date DATE «_EOTXDCRSEnd Of Open Label Treatment D/C Reason ³`BDCSRDT Double Blinded Follow-up Censor Date DATE ÈaX1CSRDT Crossover Dose1 Censor Date DATE ÐbSTCSRDT Study Censor Date DATE ØcAGETR01 Age at Vaccination 01 àdAGETRU01Age Units at Vaccination 01 èeDOMAIN Domain Abbreviation ífDSSEQ Sequence Number ï HEADER RECORD*******OBS HEADER RECORD!!!!!!!000000000000000000000000000000 C4591001C4591001 1005 10051317100513171005DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVøDW†.DVø AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀD†ÄHr^¦ÄDV×DøHr|òxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDV×....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀD†ÄHr^¦ÄDV×DøHr|òx......Phase 3A@..DVøDW†12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1005 10051317100513171005.DVøB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVøDW†.DVø AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀD†ÄHr^¦ÄDV×DøHr|òxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDV×....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀD†ÄHr^¦ÄDV×DøHr|òx......Phase 3A@..DVøDW†12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1005 10051328100513281005DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVôDWŠ.DVô AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀD°Hr^ÐDVÖD› Hr{¼ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÖ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀD°Hr^ÐDVÖD› Hr{¼ ......Phase 3A@..DVôDWŠ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1005 10051328100513281005.DVôB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVôDWŠ.DVô AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀD°Hr^ÐDVÖD› Hr{¼ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÖ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀD°Hr^ÐDVÖD› Hr{¼ ......Phase 3A@..DVôDWŠ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1005 10051339100513391005DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŠDWÄDVò AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁD¤LHr`ÌDW¨DLHsLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁD¤LHr`ÌDVÖDÒHr{óDW‘DÒðHsr|pDW¨DLHsLPhase 3A@..DVòDWŠ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1005 10051339100513391005.DVòB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŠDWÄDVò AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁD¤LHr`ÌDW¨DLHsLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁD¤LHr`ÌDVÖDÒHr{óDW‘DÒðHsr|pDW¨DLHsLPhase 3A@..DVòDWŠ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1005 10051339100513391005DW‘DW‘BÑREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŠDWÄDVò AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁD¤LHr`ÌDW¨DLHsLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁD¤LHr`ÌDVÖDÒHr{óDW‘DÒðHsr|pDW¨DLHsLPhase 3A@..DVòDWŠ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1005 10051339100513391005.DWÄC@OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŠDWÄDVòYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁD¤LHr`ÌDW¨DLHsLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁD¤LHr`ÌDVÖDÒHr{óDW‘DÒðHsr|pDW¨DLHsLPhase 3A@..DVòDWŠ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1005 10051410100514101005DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDëÈHr öÈDW¨D×(HsÓ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDëÈHr öÈDWD›dHr»dDW“DÒ´Hsu4DW¨D×(HsÓ(Phase 3A@..DW#.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1005 10051410100514101005.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDëÈHr öÈDW¨D×(HsÓ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDëÈHr öÈDWD›dHr»dDW“DÒ´Hsu4DW¨D×(HsÓ(Phase 3A@..DW#.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1005 10051410100514101005DW“DW“B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDëÈHr öÈDW¨D×(HsÓ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDëÈHr öÈDWD›dHr»dDW“DÒ´Hsu4DW¨D×(HsÓ(Phase 3A@..DW#.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA0C4591001C4591001 1005 10051410100514101005.DWÄBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW#YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDëÈHr öÈDW¨D×(HsÓ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDëÈHr öÈDWD›dHr»dDW“DÒ´Hsu4DW¨D×(HsÓ(Phase 3A@..DW#.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA@C4591001C4591001 1005 10051412100514121005DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DW½.DW0 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DŠHr§,ŒDW D‚ŒHrÄ&BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DŠHr§,ŒDW D‚ŒHrÄ&......Phase 3A@..DW0DW½12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1005 10051412100514121005.DW0B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DW½.DW0 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DŠHr§,ŒDW D‚ŒHrÄ&BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DŠHr§,ŒDW D‚ŒHrÄ&......Phase 3A@..DW0DW½12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1005 10051413100514131005DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¼.DW( AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D†Hr§(DWD‰HrÂÛBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWcBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D†Hr§(DWD‰HrÂÛ......Phase 3A@DW×.DW(DW¼12-15 YearsA YNY. DWbDW×DW×AðYEARSDSAC4591001C4591001 1005 10051413100514131005.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¼.DW( AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D†Hr§(DWD‰HrÂÛBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWcBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D†Hr§(DWD‰HrÂÛ......Phase 3A@DW×.DW(DW¼12-15 YearsA YNY. DWbDW×DW×AðYEARSDSA C4591001C4591001 1005 10051413100514131005.DW×BáFOLLOW-UP BDISPOSITION EVENTOTHER ApParticipant enrolled in C4591031 DW(DW¼.DW(YAðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D†Hr§(DWD‰HrÂÛBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWcBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D†Hr§(DWD‰HrÂÛ......Phase 3A@DW×.DW(DW¼12-15 YearsA YNY. DWbDW×DW×AðYEARSDSAPC4591001C4591001 1005 10051414100514141005DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÔDW( AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D£ Hr§E DW¸Dž¬Hs¥²¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW™DW¸.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D£ Hr§E DWD HrÂòDW™DìôHs}"tDW¸Dž¬Hs¥²¬Phase 3A@..DW(.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1005 10051414100514141005.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÔDW( AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D£ Hr§E DW¸Dž¬Hs¥²¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW™DW¸.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D£ Hr§E DWD HrÂòDW™DìôHs}"tDW¸Dž¬Hs¥²¬Phase 3A@..DW(.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1005 10051414100514141005DW™DW™B£REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÔDW( AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D£ Hr§E DW¸Dž¬Hs¥²¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW™DW¸.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D£ Hr§E DWD HrÂòDW™DìôHs}"tDW¸Dž¬Hs¥²¬Phase 3A@..DW(.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA0C4591001C4591001 1005 10051414100514141005.DWÔBÞOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÔDW(YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D£ Hr§E DW¸Dž¬Hs¥²¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW™DW¸.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D£ Hr§E DWD HrÂòDW™DìôHs}"tDW¸Dž¬Hs¥²¬Phase 3A@..DW(.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA@C4591001C4591001 1005 10051415100514151005DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÅDW( AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DçHr§‰˜DW©DÚ¬Hs’(,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DçHr§‰˜DWDÝôHrÃ/ôDW”DÇtHsvetDW©DÚ¬Hs’(,Phase 3A@..DW(.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1005 10051415100514151005.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÅDW( AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DçHr§‰˜DW©DÚ¬Hs’(,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DçHr§‰˜DWDÝôHrÃ/ôDW”DÇtHsvetDW©DÚ¬Hs’(,Phase 3A@..DW(.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1005 10051415100514151005DW”DW”BžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÅDW( AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DçHr§‰˜DW©DÚ¬Hs’(,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DçHr§‰˜DWDÝôHrÃ/ôDW”DÇtHsvetDW©DÚ¬Hs’(,Phase 3A@..DW(.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA0C4591001C4591001 1005 10051415100514151005.DWÅBÏOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÅDW(YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DçHr§‰˜DW©DÚ¬Hs’(,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DçHr§‰˜DWDÝôHrÃ/ôDW”DÇtHsvetDW©DÚ¬Hs’(,Phase 3A@..DW(.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA@C4591001C4591001 1005 10051417100514171005DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD®œHr©ôDWéD™HsæFŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWÑDWé.DWÍPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD®œHr©ôDWDœHrÅ…œDWÑD¬øHsÆ¶xDWéD™HsæFŒPhase 3A@..DW1DWË12-15 YearsA YNN. DWÌDWýDWýAÐYEARSDSAC4591001C4591001 1005 10051417100514171005.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD®œHr©ôDWéD™HsæFŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWÑDWé.DWÍPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD®œHr©ôDWDœHrÅ…œDWÑD¬øHsÆ¶xDWéD™HsæFŒPhase 3A@..DW1DWË12-15 YearsA YNN. DWÌDWýDWýAÐYEARSDSA C4591001C4591001 1005 10051417100514171005DWÑDWÑBÙREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD®œHr©ôDWéD™HsæFŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWÑDWé.DWÍPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD®œHr©ôDWDœHrÅ…œDWÑD¬øHsÆ¶xDWéD™HsæFŒPhase 3A@..DW1DWË12-15 YearsA YNN. DWÌDWýDWýAÐYEARSDSA0C4591001C4591001 1005 10051418100514181005DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¯ÈHr©õHDWD‘HrÅ†BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWÍBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¯ÈHr©õHDWD‘HrÅ†......Phase 3A@..DW1DWË12-15 YearsA YNY. DWÌDWýDWýAðYEARSDSAC4591001C4591001 1005 10051418100514181005.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¯ÈHr©õHDWD‘HrÅ†BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWÍBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¯ÈHr©õHDWD‘HrÅ†......Phase 3A@..DW1DWË12-15 YearsA YNY. DWÌDWýDWýAðYEARSDSA C4591001C4591001 1005 10051419100514191005DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWpDW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDàLHrª%ÌDWTD×(Hs"(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW?DWT.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDàLHrª%ÌDWD¬¼HrÂþ¼DW?D×ÜHsf\DWTD×(Hs"(Phase 3A@..DW(.12-15 YearsAYYNN. DW5DWýDWýAðYEARSDSAC4591001C4591001 1005 10051419100514191005.DW(B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWpDW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDàLHrª%ÌDWTD×(Hs"(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW?DWT.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDàLHrª%ÌDWD¬¼HrÂþ¼DW?D×ÜHsf\DWTD×(Hs"(Phase 3A@..DW(.12-15 YearsAYYNN. DW5DWýDWýAðYEARSDSA C4591001C4591001 1005 10051419100514191005DW?DW?BGREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWpDW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDàLHrª%ÌDWTD×(Hs"(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW?DWT.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDàLHrª%ÌDWD¬¼HrÂþ¼DW?D×ÜHsf\DWTD×(Hs"(Phase 3A@..DW(.12-15 YearsAYYNN. DW5DWýDWýAðYEARSDSA0C4591001C4591001 1005 10051419100514191005.DWpBxOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWpDW(YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDàLHrª%ÌDWTD×(Hs"(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW?DWT.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDàLHrª%ÌDWD¬¼HrÂþ¼DW?D×ÜHsf\DWTD×(Hs"(Phase 3A@..DW(.12-15 YearsAYYNN. DW5DWýDWýAðYEARSDSA@C4591001C4591001 1005 10051420100514201005DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÐ.DW( AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÞ¨Hrª$(DWD«ÌHrÂýÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÞ¨Hrª$(DWD«ÌHrÂýÌ......Phase 3A@..DW(DWÐ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1005 10051420100514201005.DW(B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÐ.DW( AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÞ¨Hrª$(DWD«ÌHrÂýÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÞ¨Hrª$(DWD«ÌHrÂýÌ......Phase 3A@..DW(DWÐ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1005 10051421100514211005DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÐDW/ AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÞ0Hr«u0DW¨DÓ¤HsÏ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÞ0Hr«u0DWDÛ$HrÇ!¤DW’DäHssßDW¨DÓ¤HsÏ¤Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1005 10051421100514211005.DW/B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÐDW/ AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÞ0Hr«u0DW¨DÓ¤HsÏ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÞ0Hr«u0DWDÛ$HrÇ!¤DW’DäHssßDW¨DÓ¤HsÏ¤Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1005 10051421100514211005DW’DW’B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÐDW/ AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÞ0Hr«u0DW¨DÓ¤HsÏ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÞ0Hr«u0DWDÛ$HrÇ!¤DW’DäHssßDW¨DÓ¤HsÏ¤Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1005 10051421100514211005.DWÐB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÐDW/YAÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÞ0Hr«u0DW¨DÓ¤HsÏ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÞ0Hr«u0DWDÛ$HrÇ!¤DW’DäHssßDW¨DÓ¤HsÏ¤Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1005 10051422100514221005DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÐDW/ AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDàHr«wDW¨DÓhHsÏhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDàHr«wDWDÛØHrÇ"XDW’DäHHssßHDW¨DÓhHsÏhPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1005 10051422100514221005.DW/B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÐDW/ AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDàHr«wDW¨DÓhHsÏhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDàHr«wDWDÛØHrÇ"XDW’DäHHssßHDW¨DÓhHsÏhPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1005 10051422100514221005DW’DW’B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÐDW/ AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDàHr«wDW¨DÓhHsÏhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDàHr«wDWDÛØHrÇ"XDW’DäHHssßHDW¨DÓhHsÏhPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1005 10051422100514221005.DWÐB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÐDW/YAÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDàHr«wDW¨DÓhHsÏhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDàHr«wDWDÛØHrÇ"XDW’DäHHssßHDW¨DÓhHsÏhPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1005 10051424100514241005DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÉ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD‡Hr¬o€DWDDHrÈDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD‡Hr¬o€DWDDHrÈD......Phase 3A@..DW3DWÉ12-15 YearsA YNY. DWŸDWýDWýAÐYEARSDSAC4591001C4591001 1005 10051424100514241005.DW3B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÉ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD‡Hr¬o€DWDDHrÈDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD‡Hr¬o€DWDDHrÈD......Phase 3A@..DW3DWÉ12-15 YearsA YNY. DWŸDWýDWýAÐYEARSDSA C4591001C4591001 1005 10051425100514251005DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÅ.DW0 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD«ÌHr¬”LDWD«ÌHrÈCÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD«ÌHr¬”LDWD«ÌHrÈCÌ......Phase 3A@..DW0DWÅ12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1005 10051425100514251005.DW0B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÅ.DW0 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD«ÌHr¬”LDWD«ÌHrÈCÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD«ÌHr¬”LDWD«ÌHrÈCÌ......Phase 3A@..DW0DWÅ12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1005 10051427100514271005DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÅDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDDHr°zDDW¦D¬øHsŽøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDDHr°zDDWD˜ÐHrÌ%PDW‘D°@HsrYÀDW¦D¬øHsŽøPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1005 10051427100514271005.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÅDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDDHr°zDDW¦D¬øHsŽøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDDHr°zDDWD˜ÐHrÌ%PDW‘D°@HsrYÀDW¦D¬øHsŽøPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1005 10051427100514271005DW‘DW‘B”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÅDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDDHr°zDDW¦D¬øHsŽøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDDHr°zDDWD˜ÐHrÌ%PDW‘D°@HsrYÀDW¦D¬øHsŽøPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1005 10051427100514271005.DWÅBÈOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÅDW/YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDDHr°zDDW¦D¬øHsŽøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDDHr°zDDWD˜ÐHrÌ%PDW‘D°@HsrYÀDW¦D¬øHsŽøPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1005 10051428100514281005DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÍŒHr°ªŒDWDƒ|HrÎ²üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÍŒHr°ªŒDWDƒ|HrÎ²ü......Phase 3A@..DW1DWË12-15 YearsA YNY. DW’DWýDWýAðYEARSDSAC4591001C4591001 1005 10051428100514281005.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÍŒHr°ªŒDWDƒ|HrÎ²üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÍŒHr°ªŒDWDƒ|HrÎ²ü......Phase 3A@..DW1DWË12-15 YearsA YNY. DW’DWýDWýAðYEARSDSA C4591001C4591001 1005 10051429100514291005DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÍ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÕHr°²DWDäÀHrÌq@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÕHr°²DWDäÀHrÌq@......Phase 3A@..DW6DWÍ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1005 10051429100514291005.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÍ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÕHr°²DWDäÀHrÌq@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÕHr°²DWDäÀHrÌq@......Phase 3A@..DW6DWÍ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1005 10051430100514301005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWDW0 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD{ÀHr±ª@DWD•HsløPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWxDW.DWuPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD{ÀHr±ª@DWD4HrÍm4DWxDˆ¤HsQ<¤DWD•HsløPhase 3A@..DW0.12-15 YearsA YNN. DWtDWýDWýAðYEARSDSAC4591001C4591001 1005 10051430100514301005.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWDW0 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD{ÀHr±ª@DWD•HsløPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWxDW.DWuPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD{ÀHr±ª@DWD4HrÍm4DWxDˆ¤HsQ<¤DWD•HsløPhase 3A@..DW0.12-15 YearsA YNN. DWtDWýDWýAðYEARSDSA C4591001C4591001 1005 10051430100514301005DWxDWxBzREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWDW0 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD{ÀHr±ª@DWD•HsløPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWxDW.DWuPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD{ÀHr±ª@DWD4HrÍm4DWxDˆ¤HsQ<¤DWD•HsløPhase 3A@..DW0.12-15 YearsA YNN. DWtDWýDWýAðYEARSDSA0C4591001C4591001 1005 10051430100514301005.DWB¯OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWDW0YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD{ÀHr±ª@DWD•HsløPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWxDW.DWuPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD{ÀHr±ª@DWD4HrÍm4DWxDˆ¤HsQ<¤DWD•HsløPhase 3A@..DW0.12-15 YearsA YNN. DWtDWýDWýAðYEARSDSA@C4591001C4591001 1005 10051431100514311005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÑ.DW0 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD‡ðHr±¶pDWD¦àHrÍ„àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD‡ðHr±¶pDWD¦àHrÍ„à......Phase 3A@..DW0DWÑ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1005 10051431100514311005.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÑ.DW0 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD‡ðHr±¶pDWD¦àHrÍ„àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD‡ðHr±¶pDWD¦àHrÍ„à......Phase 3A@..DW0DWÑ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1005 10051436100514361005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÅ.DW6 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD®ØHr±ÝXDWDÊ¼HrÍ¨¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD®ØHr±ÝXDWDÊ¼HrÍ¨¼......Phase 3A@..DW6DWÅ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1005 10051436100514361005.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÅ.DW6 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD®ØHr±ÝXDWDÊ¼HrÍ¨¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD®ØHr±ÝXDWDÊ¼HrÍ¨¼......Phase 3A@..DW6DWÅ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1005 10051437100514371005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDpHr±ÛðDW°D™üHs›!üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW›DW°.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDpHr±ÛðDWDÊøHrÍ¨øDW›D’@HsjÀDW°D™üHs›!üPhase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1005 10051437100514371005.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDpHr±ÛðDW°D™üHs›!üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW›DW°.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDpHr±ÛðDWDÊøHrÍ¨øDW›D’@HsjÀDW°D™üHs›!üPhase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1005 10051437100514371005DW›DW›BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDpHr±ÛðDW°D™üHs›!üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW›DW°.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDpHr±ÛðDWDÊøHrÍ¨øDW›D’@HsjÀDW°D™üHs›!üPhase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA0C4591001C4591001 1005 10051437100514371005.DWÐBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDpHr±ÛðDW°D™üHs›!üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW›DW°.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDpHr±ÛðDWDÊøHrÍ¨øDW›D’@HsjÀDW°D™üHs›!üPhase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA@C4591001C4591001 1005 10051438100514381005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD«ÌHr±ÚLDW°D™„Hs›!„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW›DW°.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD«ÌHr±ÚLDWDÍŒHrÍ«ŒDW›D‘ÈHsjHDW°D™„Hs›!„Phase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1005 10051438100514381005.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD«ÌHr±ÚLDW°D™„Hs›!„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW›DW°.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD«ÌHr±ÚLDWDÍŒHrÍ«ŒDW›D‘ÈHsjHDW°D™„Hs›!„Phase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1005 10051438100514381005DW›DW›BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD«ÌHr±ÚLDW°D™„Hs›!„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW›DW°.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD«ÌHr±ÚLDWDÍŒHrÍ«ŒDW›D‘ÈHsjHDW°D™„Hs›!„Phase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA0C4591001C4591001 1005 10051438100514381005.DWÐBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD«ÌHr±ÚLDW°D™„Hs›!„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW›DW°.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD«ÌHr±ÚLDWDÍŒHrÍ«ŒDW›D‘ÈHsjHDW°D™„Hs›!„Phase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA@C4591001C4591001 1005 10051439100514391005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÉ.DW0 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÔ”Hr²DWDÕüHrÌb|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÔ”Hr²DWDÕüHrÌb|......Phase 3A@..DW0DWÉ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1005 10051439100514391005.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÉ.DW0 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÔ”Hr²DWDÕüHrÌb|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÔ”Hr²DWDÕüHrÌb|......Phase 3A@..DW0DWÉ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1005 10051440100514401005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÄDW0 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÕHHr²ÈDW¨DÄhHsÀhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÕHHr²ÈDWDÕHrÌaŒDW“D¬¼Hstù<DW¨DÄhHsÀhPhase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1005 10051440100514401005.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÄDW0 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÕHHr²ÈDW¨DÄhHsÀhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÕHHr²ÈDWDÕHrÌaŒDW“D¬¼Hstù<DW¨DÄhHsÀhPhase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1005 10051440100514401005DW“DW“B•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÄDW0 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÕHHr²ÈDW¨DÄhHsÀhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÕHHr²ÈDWDÕHrÌaŒDW“D¬¼Hstù<DW¨DÄhHsÀhPhase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1005 10051440100514401005.DWÄBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÄDW0YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÕHHr²ÈDW¨DÄhHsÀhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÕHHr²ÈDWDÕHrÌaŒDW“D¬¼Hstù<DW¨DÄhHsÀhPhase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1005 10051441100514411005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÄ.DW1 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÒðHr²pDWDÈ(HrÍ¦(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÒðHr²pDWDÈ(HrÍ¦(......Phase 3A@DWá.DW1DWÄ12-15 YearsA YNY. DW’DWáDWáAðYEARSDSAC4591001C4591001 1005 10051441100514411005.DW1B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÄ.DW1 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÒðHr²pDWDÈ(HrÍ¦(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÒðHr²pDWDÈ(HrÍ¦(......Phase 3A@DWá.DW1DWÄ12-15 YearsA YNY. DW’DWáDWáAðYEARSDSA C4591001C4591001 1005 10051441100514411005.DWáBãFOLLOW-UP BDISPOSITION EVENTOTHER ApParticipant enrolled in C4591031 DW1DWÄ.DW1YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÒðHr²pDWDÈ(HrÍ¦(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÒðHr²pDWDÈ(HrÍ¦(......Phase 3A@DWá.DW1DWÄ12-15 YearsA YNY. DW’DWáDWáAðYEARSDSAPC4591001C4591001 1005 10051444100514441005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÅDW0 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDædHr²äDW©D0ÀHs‘~@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDædHr²äDWDÙHrÍ·DW”DÖìHsvtìDW©D0ÀHs‘~@Phase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1005 10051444100514441005.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÅDW0 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDædHr²äDW©D0ÀHs‘~@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDædHr²äDWDÙHrÍ·DW”DÖìHsvtìDW©D0ÀHs‘~@Phase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1005 10051444100514441005DW”DW”B–REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÅDW0 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDædHr²äDW©D0ÀHs‘~@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDædHr²äDWDÙHrÍ·DW”DÖìHsvtìDW©D0ÀHs‘~@Phase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA0C4591001C4591001 1005 10051444100514441005.DWÅBÇOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÅDW0YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDædHr²äDW©D0ÀHs‘~@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDædHr²äDWDÙHrÍ·DW”DÖìHsvtìDW©D0ÀHs‘~@Phase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA@C4591001C4591001 1005 10051445100514451005DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÌDW0 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDì¸Hr²8DW¯D~ÌHs™µLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWšDW¯.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDì¸Hr²8DWDœTHrÍzTDWšD€¬Hs~¬DW¯D~ÌHs™µLPhase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1005 10051445100514451005.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÌDW0 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDì¸Hr²8DW¯D~ÌHs™µLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWšDW¯.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDì¸Hr²8DWDœTHrÍzTDWšD€¬Hs~¬DW¯D~ÌHs™µLPhase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1005 10051445100514451005DWšDWšBœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÌDW0 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDì¸Hr²8DW¯D~ÌHs™µLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWšDW¯.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDì¸Hr²8DWDœTHrÍzTDWšD€¬Hs~¬DW¯D~ÌHs™µLPhase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1005 10051445100514451005.DWÌBÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÌDW0YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDì¸Hr²8DW¯D~ÌHs™µLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWšDW¯.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDì¸Hr²8DWDœTHrÍzTDWšD€¬Hs~¬DW¯D~ÌHs™µLPhase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1005 10051447100514471005DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD—àHrÌ$`DW(DŽDHrçÊDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD—àHrÌ$`DW(DŽDHrçÊD......Phase 3A@..DWDDW×12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1005 10051447100514471005.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD—àHrÌ$`DW(DŽDHrçÊDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD—àHrÌ$`DW(DŽDHrçÊD......Phase 3A@..DWDDW×12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1005 10051448100514481005DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÐDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¶”HrÌCDW¯DÂHs™øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWšDW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¶”HrÌCDW(D HrçÜDWšD‡ðHs~ðDW¯DÂHs™øPhase 3A@..DWD.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1005 10051448100514481005.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÐDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¶”HrÌCDW¯DÂHs™øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWšDW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¶”HrÌCDW(D HrçÜDWšD‡ðHs~ðDW¯DÂHs™øPhase 3A@..DWD.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1005 10051448100514481005DWšDWšBˆREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÐDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¶”HrÌCDW¯DÂHs™øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWšDW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¶”HrÌCDW(D HrçÜDWšD‡ðHs~ðDW¯DÂHs™øPhase 3A@..DWD.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1005 10051448100514481005.DWÐB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÐDWDYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¶”HrÌCDW¯DÂHs™øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWšDW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¶”HrÌCDW(D HrçÜDWšD‡ðHs~ðDW¯DÂHs™øPhase 3A@..DWD.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1005 10051449100514491005DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÞ.DWD AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD´HrÌ@€DW(DŸœHrçÛœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD´HrÌ@€DW(DŸœHrçÛœ......Phase 3A@..DWDDWÞ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1005 10051449100514491005.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÞ.DWD AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD´HrÌ@€DW(DŸœHrçÛœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD´HrÌ@€DW(DŸœHrçÛœ......Phase 3A@..DWDDWÞ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1005 10051450100514501005DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÐDWD AàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÑˆHrÌ^DWDÙøHs—mxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW˜DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑˆHrÌ^DW(DÜPHrèPDW˜Dá<Hs{Å<DWDÙøHs—mxPhase 3A@..DWD.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1005 10051450100514501005.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÐDWD AàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÑˆHrÌ^DWDÙøHs—mxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW˜DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑˆHrÌ^DW(DÜPHrèPDW˜Dá<Hs{Å<DWDÙøHs—mxPhase 3A@..DWD.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1005 10051450100514501005DW˜DW˜B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÐDWD AàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÑˆHrÌ^DWDÙøHs—mxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW˜DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑˆHrÌ^DW(DÜPHrèPDW˜Dá<Hs{Å<DWDÙøHs—mxPhase 3A@..DWD.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1005 10051450100514501005.DWÐB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÐDWDYAàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÑˆHrÌ^DWDÙøHs—mxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW˜DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑˆHrÌ^DW(DÜPHrèPDW˜Dá<Hs{Å<DWDÙøHs—mxPhase 3A@..DWD.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1005 10051451100514511005DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWå.DWF AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌ`HrÍª`DW*D¶Hrê•BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWåBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌ`HrÍª`DW*D¶Hrê•......Phase 3A@..DWFDWå12-15 YearsA YNY. DWäDWýDWýAðYEARSDSAC4591001C4591001 1005 10051451100514511005.DWFB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWå.DWF AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌ`HrÍª`DW*D¶Hrê•BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWåBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌ`HrÍª`DW*D¶Hrê•......Phase 3A@..DWFDWå12-15 YearsA YNY. DWäDWýDWýAðYEARSDSA C4591001C4591001 1006 10061183100611831006DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÉDW0 AàYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVéD„0Hr”±°DW§D‚Hs,”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDW.DW”DW§.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéD„0Hr”±°DWD†HrÆÌDW”D‘ÈHsv/ÈDW§D‚Hs,”Phase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1006 10061183100611831006.DW0BHVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÉDW0 AàYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVéD„0Hr”±°DW§D‚Hs,”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDW.DW”DW§.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéD„0Hr”±°DWD†HrÆÌDW”D‘ÈHsv/ÈDW§D‚Hs,”Phase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1006 10061183100611831006DW”DW”B¬REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÉDW0 AàYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVéD„0Hr”±°DW§D‚Hs,”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDW.DW”DW§.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéD„0Hr”±°DWD†HrÆÌDW”D‘ÈHsv/ÈDW§D‚Hs,”Phase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1006 10061183100611831006.DWÉBáOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÉDW0YAàYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVéD„0Hr”±°DW§D‚Hs,”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDW.DW”DW§.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéD„0Hr”±°DWD†HrÆÌDW”D‘ÈHsv/ÈDW§D‚Hs,”Phase 3A@..DW0.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1006 10061184100611841006DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD©tHr”ÖôDVþD›ÜHr°xÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW¦BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD©tHr”ÖôDVþD›ÜHr°xÜ......Phase 3A@..DWDW12-15 YearsAYYNY. DW¥DWýDWýAðYEARSDSAC4591001C4591001 1006 10061184100611841006.DWB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD©tHr”ÖôDVþD›ÜHr°xÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW¦BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD©tHr”ÖôDVþD›ÜHr°xÜ......Phase 3A@..DWDW12-15 YearsAYYNY. DW¥DWýDWýAðYEARSDSA C4591001C4591001 1006 10061188100611881006DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVêDô°Hr–s°DW¦DïÄHsŽHÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDô°Hr–s°DVÿDúŒHr²)DW’DðHssëDW¦DïÄHsŽHÄPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1006 10061188100611881006.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVêDô°Hr–s°DW¦DïÄHsŽHÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDô°Hr–s°DVÿDúŒHr²)DW’DðHssëDW¦DïÄHsŽHÄPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1006 10061188100611881006DW’DW’B©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVêDô°Hr–s°DW¦DïÄHsŽHÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDô°Hr–s°DVÿDúŒHr²)DW’DðHssëDW¦DïÄHsŽHÄPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1006 10061188100611881006.DWÉBàOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDWYAÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVêDô°Hr–s°DW¦DïÄHsŽHÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDô°Hr–s°DVÿDúŒHr²)DW’DðHssëDW¦DïÄHsŽHÄPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1006 10061189100611891006DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDô°Hr–s°DVÿDîÔHr²TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDô°Hr–s°DVÿDîÔHr²T......Phase 3A@..DWDW®12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1006 10061189100611891006.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDô°Hr–s°DVÿDîÔHr²TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDô°Hr–s°DVÿDîÔHr²T......Phase 3A@..DWDW®12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1006 10061190100611901006DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD|°Hr—M0DVÿD’¸Hr±Á8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD|°Hr—M0DVÿD’¸Hr±Á8......Phase 3A@..DWDW°12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1006 10061190100611901006.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD|°Hr—M0DVÿD’¸Hr±Á8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD|°Hr—M0DVÿD’¸Hr±Á8......Phase 3A@..DWDW°12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1006 10061191100611911006DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW±.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDœÌHr—mLDVÿD—¤Hr±Æ$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDœÌHr—mLDVÿD—¤Hr±Æ$......Phase 3A@..DWDW±12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1006 10061191100611911006.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW±.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDœÌHr—mLDVÿD—¤Hr±Æ$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDœÌHr—mLDVÿD—¤Hr±Æ$......Phase 3A@..DWDW±12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1006 10061196100611961006DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDý Hr—Í DW§D©tHsSôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW“DW§.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDý Hr—Í DVþD÷¼Hr°Ô¼DW“DÅÐHsuPDW§D©tHsSôPhase 3A@..DW.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1006 10061196100611961006.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDý Hr—Í DW§D©tHsSôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW“DW§.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDý Hr—Í DVþD÷¼Hr°Ô¼DW“DÅÐHsuPDW§D©tHsSôPhase 3A@..DW.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1006 10061196100611961006DW“DW“B©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDý Hr—Í DW§D©tHsSôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW“DW§.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDý Hr—Í DVþD÷¼Hr°Ô¼DW“DÅÐHsuPDW§D©tHsSôPhase 3A@..DW.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA0C4591001C4591001 1006 10061196100611961006.DWÃBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDWYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDý Hr—Í DW§D©tHsSôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW“DW§.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDý Hr—Í DVþD÷¼Hr°Ô¼DW“DÅÐHsuPDW§D©tHsSôPhase 3A@..DW.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA@C4591001C4591001 1006 10061200100612001006DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW‹DW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÒ´Hr˜ô´DWiD–ðHs=„pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DWSDWi.DWFPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÒ´Hr˜ô´DWD4Hr´`´DWSDïLHs ÛÌDWiD–ðHs=„pPhase 3A@DWö.DW$.12-15 YearsA YNN. DWEDWöDWöAðYEARSDSAC4591001C4591001 1006 10061200100612001006.DW$B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW‹DW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÒ´Hr˜ô´DWiD–ðHs=„pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DWSDWi.DWFPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÒ´Hr˜ô´DWD4Hr´`´DWSDïLHs ÛÌDWiD–ðHs=„pPhase 3A@DWö.DW$.12-15 YearsA YNN. DWEDWöDWöAðYEARSDSA C4591001C4591001 1006 10061200100612001006DWSDWSBhREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW‹DW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÒ´Hr˜ô´DWiD–ðHs=„pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DWSDWi.DWFPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÒ´Hr˜ô´DWD4Hr´`´DWSDïLHs ÛÌDWiD–ðHs=„pPhase 3A@DWö.DW$.12-15 YearsA YNN. DWEDWöDWöAðYEARSDSA0C4591001C4591001 1006 10061200100612001006.DW‹B OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW‹DW$YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÒ´Hr˜ô´DWiD–ðHs=„pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DWSDWi.DWFPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÒ´Hr˜ô´DWD4Hr´`´DWSDïLHs ÛÌDWiD–ðHs=„pPhase 3A@DWö.DW$.12-15 YearsA YNN. DWEDWöDWöAðYEARSDSA@C4591001C4591001 1006 10061200100612001006.DWöC°FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APLost to follow-up, noncompliant DW$.DW‹DW$YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÒ´Hr˜ô´DWiD–ðHs=„pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DWSDWi.DWFPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÒ´Hr˜ô´DWD4Hr´`´DWSDïLHs ÛÌDWiD–ðHs=„pPhase 3A@DWö.DW$.12-15 YearsA YNN. DWEDWöDWöAðYEARSDSApC4591001C4591001 1006 10061201100612011006DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DWÄ.DW$ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDÒxHr˜ôxDWDpHr´`ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDÒxHr˜ôxDWDpHr´`ð......Phase 3A@..DW$DWÄ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1006 10061201100612011006.DW$B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DWÄ.DW$ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDÒxHr˜ôxDWDpHr´`ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDÒxHr˜ôxDWDpHr´`ð......Phase 3A@..DW$DWÄ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1006 10061203100612031006DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDòXHr™XDVÿD©8Hr±×¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DWšBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDòXHr™XDVÿD©8Hr±×¸......Phase 3A@..DWDW°12-15 YearsA YNY. DW™DWýDWýAÐYEARSDSAC4591001C4591001 1006 10061203100612031006.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDòXHr™XDVÿD©8Hr±×¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DWšBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDòXHr™XDVÿD©8Hr±×¸......Phase 3A@..DWDW°12-15 YearsA YNY. DW™DWýDWýAÐYEARSDSA C4591001C4591001 1006 10061206100612061006DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‚PHr™õÐDWDDHr²ÿDPlacebo Placebo 12-15 YearsA . . .DVíDW....DW’Placebo Placebo Placebo A .Placebo A .DVíD‚PHr™õÐDWDDHr²ÿD......Phase 3A@DW’.DW.12-15 YearsA YNN. DW‘DW’DW’AÀYEARSDSAC4591001C4591001 1006 10061206100612061006.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‚PHr™õÐDWDDHr²ÿDPlacebo Placebo 12-15 YearsA . . .DVíDW....DW’Placebo Placebo Placebo A .Placebo A .DVíD‚PHr™õÐDWDDHr²ÿD......Phase 3A@DW’.DW.12-15 YearsA YNN. DW‘DW’DW’AÀYEARSDSA C4591001C4591001 1006 10061206100612061006.DW’B¦FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT Bparent requested to withdraw consent DW..DWYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‚PHr™õÐDWDDHr²ÿDPlacebo Placebo 12-15 YearsA . . .DVíDW....DW’Placebo Placebo Placebo A .Placebo A .DVíD‚PHr™õÐDWDDHr²ÿD......Phase 3A@DW’.DW.12-15 YearsA YNN. DW‘DW’DW’AÀYEARSDSA`C4591001C4591001 1006 10061207100612071006DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‚ŒHr™öDWDHr²ÿPlacebo Placebo 12-15 YearsA . . .DVíDW....DW’Placebo Placebo Placebo A .Placebo A .DVíD‚ŒHr™öDWDHr²ÿ......Phase 3A@DW’.DW.12-15 YearsA YNN. DW‘DW’DW’AàYEARSDSAC4591001C4591001 1006 10061207100612071006.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‚ŒHr™öDWDHr²ÿPlacebo Placebo 12-15 YearsA . . .DVíDW....DW’Placebo Placebo Placebo A .Placebo A .DVíD‚ŒHr™öDWDHr²ÿ......Phase 3A@DW’.DW.12-15 YearsA YNN. DW‘DW’DW’AàYEARSDSA C4591001C4591001 1006 10061207100612071006.DW’B¦FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT Bparticipant withdrew consent DW..DWYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‚ŒHr™öDWDHr²ÿPlacebo Placebo 12-15 YearsA . . .DVíDW....DW’Placebo Placebo Placebo A .Placebo A .DVíD‚ŒHr™öDWDHr²ÿ......Phase 3A@DW’.DW.12-15 YearsA YNN. DW‘DW’DW’AàYEARSDSA`C4591001C4591001 1006 10061209100612091006DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDªÜHrš\DWDžèHr³èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDªÜHrš\DWDžèHr³è......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1006 10061209100612091006.DW"B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDªÜHrš\DWDžèHr³èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDªÜHrš\DWDžèHr³è......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1006 10061212100612121006DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÅDW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDÊ€Hrš>DW§DÃ<Hsm¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDÊ€Hrš>DWD™üHr³üDW’D›(Hss–(DW§DÃ<Hsm¼Phase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061212100612121006.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÅDW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDÊ€Hrš>DW§DÃ<Hsm¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDÊ€Hrš>DWD™üHr³üDW’D›(Hss–(DW§DÃ<Hsm¼Phase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061212100612121006DW’DW’B¦REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÅDW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDÊ€Hrš>DW§DÃ<Hsm¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDÊ€Hrš>DWD™üHr³üDW’D›(Hss–(DW§DÃ<Hsm¼Phase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1006 10061212100612121006.DWÅBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÅDWYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDÊ€Hrš>DW§DÃ<Hsm¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDÊ€Hrš>DWD™üHr³üDW’D›(Hss–(DW§DÃ<Hsm¼Phase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1006 10061213100612131006DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDÊDHrš=ÄDWDŠÀHr³ ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDÊDHrš=ÄDWDŠÀHr³ À......Phase 3A@..DWDW¯12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1006 10061213100612131006.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDÊDHrš=ÄDWDŠÀHr³ ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDÊDHrš=ÄDWDŠÀHr³ À......Phase 3A@..DWDW¯12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1006 10061214100612141006DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVíDß˜HršSDW´DÕ„Hs £„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDß˜HršSDWDÚ¬Hr³Z¬DW’Dâ¤HssÝ¤DW´DÕ„Hs £„Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1006 10061214100612141006.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVíDß˜HršSDW´DÕ„Hs £„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDß˜HršSDWDÚ¬Hr³Z¬DW’Dâ¤HssÝ¤DW´DÕ„Hs £„Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1006 10061214100612141006DW’DW’B¦REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVíDß˜HršSDW´DÕ„Hs £„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDß˜HršSDWDÚ¬Hr³Z¬DW’Dâ¤HssÝ¤DW´DÕ„Hs £„Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1006 10061214100612141006.DWÐBäOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDWYAàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVíDß˜HršSDW´DÕ„Hs £„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDß˜HršSDWDÚ¬Hr³Z¬DW’Dâ¤HssÝ¤DW´DÕ„Hs £„Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1006 10061219100612191006DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWüDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD‹tHrótDWÛDÛ$HsÔ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW®DWÛ.DW®Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD‹tHrótDWDœHr´SDW®DŠHHs˜oHDWÛDÛ$HsÔ¤Phase 3A@..DW!.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061219100612191006.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWüDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD‹tHrótDWÛDÛ$HsÔ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW®DWÛ.DW®Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD‹tHrótDWDœHr´SDW®DŠHHs˜oHDWÛDÛ$HsÔ¤Phase 3A@..DW!.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061219100612191006DW®DW®B¿REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWüDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD‹tHrótDWÛDÛ$HsÔ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW®DWÛ.DW®Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD‹tHrótDWDœHr´SDW®DŠHHs˜oHDWÛDÛ$HsÔ¤Phase 3A@..DW!.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1006 10061219100612191006.DWüCÐOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWüDW!YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD‹tHrótDWÛDÛ$HsÔ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW®DWÛ.DW®Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD‹tHrótDWDœHr´SDW®DŠHHs˜oHDWÛDÛ$HsÔ¤Phase 3A@..DW!.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1006 10061220100612201006DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¶.DW% AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDš8Hrž8DWDHr¹¤˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW7BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDš8Hrž8DWDHr¹¤˜......Phase 3A@..DW%DW¶12-15 YearsAYYNY. DW6DWýDWýAðYEARSDSAC4591001C4591001 1006 10061220100612201006.DW%B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¶.DW% AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDš8Hrž8DWDHr¹¤˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW7BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDš8Hrž8DWDHr¹¤˜......Phase 3A@..DW%DW¶12-15 YearsAYYNY. DW6DWýDWýAðYEARSDSA C4591001C4591001 1006 10061221100612211006DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DWµ.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDªÜHržÜDWD¥´Hr¹½4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDªÜHržÜDWD¥´Hr¹½4......Phase 3A@DWÞ.DW%DWµ12-15 YearsA YNY. DW‘DWÞDWÞAðYEARSDSAC4591001C4591001 1006 10061221100612211006.DW%B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DWµ.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDªÜHržÜDWD¥´Hr¹½4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDªÜHržÜDWD¥´Hr¹½4......Phase 3A@DWÞ.DW%DWµ12-15 YearsA YNY. DW‘DWÞDWÞAðYEARSDSA C4591001C4591001 1006 10061221100612211006.DWÞBïFOLLOW-UP BDISPOSITION EVENTOTHER Apenrolled in C4591031 DW%DWµ.DW%YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDªÜHržÜDWD¥´Hr¹½4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDªÜHržÜDWD¥´Hr¹½4......Phase 3A@DWÞ.DW%DWµ12-15 YearsA YNY. DW‘DWÞDWÞAðYEARSDSAPC4591001C4591001 1006 10061223100612231006DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÅDW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÂHrž*DW§DDHsGÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÂHrž*DWDóüHr¼®|DW‘D{Hsr$ŒDW§DDHsGÄPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061223100612231006.DW)B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÅDW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÂHrž*DW§DDHsGÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÂHrž*DWDóüHr¼®|DW‘D{Hsr$ŒDW§DDHsGÄPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061223100612231006DW‘DW‘B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÅDW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÂHrž*DW§DDHsGÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÂHrž*DWDóüHr¼®|DW‘D{Hsr$ŒDW§DDHsGÄPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061223100612231006.DWÅBÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÅDW)YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÂHrž*DW§DDHsGÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÂHrž*DWDóüHr¼®|DW‘D{Hsr$ŒDW§DDHsGÄPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1006 10061224100612241006DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DWÅ.DW% AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÕHHrž=HDWDŠHHr¹¡ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÕHHrž=HDWDŠHHr¹¡È......Phase 3A@..DW%DWÅ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1006 10061224100612241006.DW%B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DWÅ.DW% AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÕHHrž=HDWDŠHHr¹¡ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÕHHrž=HDWDŠHHr¹¡È......Phase 3A@..DW%DWÅ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1006 10061226100612261006DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÅDW! AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDçÌHržOÌDW£D™ÀHs‰þ@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDçÌHržOÌDWDõÜHrº \DWŽDŸ$HsnT$DW£D™ÀHs‰þ@Phase 3A@..DW!.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1006 10061226100612261006.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÅDW! AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDçÌHržOÌDW£D™ÀHs‰þ@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDçÌHržOÌDWDõÜHrº \DWŽDŸ$HsnT$DW£D™ÀHs‰þ@Phase 3A@..DW!.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1006 10061226100612261006DWŽDWŽBŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÅDW! AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDçÌHržOÌDW£D™ÀHs‰þ@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDçÌHržOÌDWDõÜHrº \DWŽDŸ$HsnT$DW£D™ÀHs‰þ@Phase 3A@..DW!.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061226100612261006.DWÅBÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÅDW!YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDçÌHržOÌDW£D™ÀHs‰þ@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDçÌHržOÌDWDõÜHrº \DWŽDŸ$HsnT$DW£D™ÀHs‰þ@Phase 3A@..DW!.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1006 10061227100612271006DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDèHržPDWDöHrº ˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDèHržPDWDöHrº ˜......Phase 3A@..DW!DW´12-15 YearsAYYNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1006 10061227100612271006.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDèHržPDWDöHrº ˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDèHržPDWDöHrº ˜......Phase 3A@..DW!DW´12-15 YearsAYYNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1006 10061228100612281006DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÅDW$ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD™ÀHrŸS@DW£DË4HsŠ/´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD™ÀHrŸS@DWDÆHHr»/HDWŽDŸ$HsnT$DW£DË4HsŠ/´Phase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1006 10061228100612281006.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÅDW$ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD™ÀHrŸS@DW£DË4HsŠ/´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD™ÀHrŸS@DWDÆHHr»/HDWŽDŸ$HsnT$DW£DË4HsŠ/´Phase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1006 10061228100612281006DWŽDWŽBžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÅDW$ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD™ÀHrŸS@DW£DË4HsŠ/´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD™ÀHrŸS@DWDÆHHr»/HDWŽDŸ$HsnT$DW£DË4HsŠ/´Phase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1006 10061228100612281006.DWÅBÕOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÅDW$YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD™ÀHrŸS@DW£DË4HsŠ/´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD™ÀHrŸS@DWDÆHHr»/HDWŽDŸ$HsnT$DW£DË4HsŠ/´Phase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1006 10061229100612291006DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWjDW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD¶ÐHrŸpPDWNDè€Hs=€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW9DWN.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD¶ÐHrŸpPDWD®$Hr»$DW9DéèHrþhDWNDè€Hs=€Phase 3A@..DW(.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSAC4591001C4591001 1006 10061229100612291006.DW(B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWjDW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD¶ÐHrŸpPDWNDè€Hs=€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW9DWN.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD¶ÐHrŸpPDWD®$Hr»$DW9DéèHrþhDWNDè€Hs=€Phase 3A@..DW(.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA C4591001C4591001 1006 10061229100612291006DW9DW9BIREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWjDW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD¶ÐHrŸpPDWNDè€Hs=€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW9DWN.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD¶ÐHrŸpPDWD®$Hr»$DW9DéèHrþhDWNDè€Hs=€Phase 3A@..DW(.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA0C4591001C4591001 1006 10061229100612291006.DWjBzOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWjDW(YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD¶ÐHrŸpPDWNDè€Hs=€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW9DWN.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD¶ÐHrŸpPDWD®$Hr»$DW9DéèHrþhDWNDè€Hs=€Phase 3A@..DW(.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA@C4591001C4591001 1006 10061230100612301006DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÃ.DW) AàYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDððHrŸªpDWD±0Hr½½0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDððHrŸªpDWD±0Hr½½0......Phase 3A@..DW)DWÃ12-15 YearsAYYNY. DW“DWýDWýAàYEARSDSAC4591001C4591001 1006 10061230100612301006.DW)B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÃ.DW) AàYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDððHrŸªpDWD±0Hr½½0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDððHrŸªpDWD±0Hr½½0......Phase 3A@..DW)DWÃ12-15 YearsAYYNY. DW“DWýDWýAàYEARSDSA C4591001C4591001 1006 10061231100612311006DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DW´.DW" AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDöÌHrŸ°LDWDŽ¼Hr¹¦<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDöÌHrŸ°LDWDŽ¼Hr¹¦<......Phase 3A@..DW"DW´12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1006 10061231100612311006.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DW´.DW" AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDöÌHrŸ°LDWDŽ¼Hr¹¦<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDöÌHrŸ°LDWDŽ¼Hr¹¦<......Phase 3A@..DW"DW´12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1006 10061232100612321006DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDü0HrŸµ°DW§D÷¼Hs¢<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDü0HrŸµ°DWDþˆHr»gˆDW’Dû@Hssö@DW§D÷¼Hs¢<Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061232100612321006.DW#B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDü0HrŸµ°DW§D÷¼Hs¢<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDü0HrŸµ°DWDþˆHr»gˆDW’Dû@Hssö@DW§D÷¼Hs¢<Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061232100612321006DW’DW’B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDü0HrŸµ°DW§D÷¼Hs¢<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDü0HrŸµ°DWDþˆHr»gˆDW’Dû@Hssö@DW§D÷¼Hs¢<Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1006 10061232100612321006.DWÅBÕOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW#YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDü0HrŸµ°DW§D÷¼Hs¢<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDü0HrŸµ°DWDþˆHr»gˆDW’Dû@Hssö@DW§D÷¼Hs¢<Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1006 10061233100612331006DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDûHrŸ´„DW§D÷øHs¢xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDûHrŸ´„DWDþÄHr»gÄDW’Dû|Hssö|DW§D÷øHs¢xPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061233100612331006.DW#B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDûHrŸ´„DW§D÷øHs¢xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDûHrŸ´„DWDþÄHr»gÄDW’Dû|Hssö|DW§D÷øHs¢xPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061233100612331006DW’DW’B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDûHrŸ´„DW§D÷øHs¢xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDûHrŸ´„DWDþÄHr»gÄDW’Dû|Hssö|DW§D÷øHs¢xPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061233100612331006.DWÅBÕOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW#YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDûHrŸ´„DW§D÷øHs¢xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDûHrŸ´„DWDþÄHr»gÄDW’Dû|Hssö|DW§D÷øHs¢xPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1006 10061234100612341006DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD~THr ‰TDWD}(Hr¼7¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD~THr ‰TDWD}(Hr¼7¨......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061234100612341006.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD~THr ‰TDWD}(Hr¼7¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD~THr ‰TDWD}(Hr¼7¨......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061235100612351006DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD~Hr ‰DW§D~Hs)Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW“DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD~Hr ‰DWD}dHr¼7äDW“DÉHsuDW§D~Hs)Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061235100612351006.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD~Hr ‰DW§D~Hs)Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW“DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD~Hr ‰DWD}dHr¼7äDW“DÉHsuDW§D~Hs)Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061235100612351006DW“DW“B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD~Hr ‰DW§D~Hs)Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW“DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD~Hr ‰DWD}dHr¼7äDW“DÉHsuDW§D~Hs)Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061235100612351006.DWÃBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW#YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD~Hr ‰DW§D~Hs)Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW“DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD~Hr ‰DWD}dHr¼7äDW“DÉHsuDW§D~Hs)Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1006 10061236100612361006DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDŸ`Hr ª`DWDÈ Hr¹à BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDŸ`Hr ª`DWDÈ Hr¹à ......Phase 3A@..DW!DW´12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061236100612361006.DW!B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDŸ`Hr ª`DWDÈ Hr¹à BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDŸ`Hr ª`DWDÈ Hr¹à ......Phase 3A@..DW!DW´12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061237100612371006DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW½DW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD£ÔHr ®ÔDW¡DÁ\Hs‡‚ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD£ÔHr ®ÔDWD¸ìHr¹ÐlDWŽDÕHsnŠDW¡DÁ\Hs‡‚ÜPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1006 10061237100612371006.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW½DW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD£ÔHr ®ÔDW¡DÁ\Hs‡‚ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD£ÔHr ®ÔDWD¸ìHr¹ÐlDWŽDÕHsnŠDW¡DÁ\Hs‡‚ÜPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1006 10061237100612371006DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW½DW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD£ÔHr ®ÔDW¡DÁ\Hs‡‚ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD£ÔHr ®ÔDWD¸ìHr¹ÐlDWŽDÕHsnŠDW¡DÁ\Hs‡‚ÜPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1006 10061237100612371006.DW½BÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW½DW#YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD£ÔHr ®ÔDW¡DÁ\Hs‡‚ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD£ÔHr ®ÔDWD¸ìHr¹ÐlDWŽDÕHsnŠDW¡DÁ\Hs‡‚ÜPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1006 10061239100612391006DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÆDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD®ØHr ¹ØDW¨DøèHsôèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD®ØHr ¹ØDWDª Hr¼e DW‘Dù`Hsr¢àDW¨DøèHsôèPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061239100612391006.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÆDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD®ØHr ¹ØDW¨DøèHsôèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD®ØHr ¹ØDWDª Hr¼e DW‘Dù`Hsr¢àDW¨DøèHsôèPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061239100612391006DW‘DW‘B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÆDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD®ØHr ¹ØDW¨DøèHsôèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD®ØHr ¹ØDWDª Hr¼e DW‘Dù`Hsr¢àDW¨DøèHsôèPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1006 10061239100612391006.DWÆBÕOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÆDW#YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD®ØHr ¹ØDW¨DøèHsôèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD®ØHr ¹ØDWDª Hr¼e DW‘Dù`Hsr¢àDW¨DøèHsôèPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1006 10061241100612411006DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµ.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÉÌHr ÔÌDWDÒHr¹é€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÉÌHr ÔÌDWDÒHr¹é€......Phase 3A@..DW#DWµ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061241100612411006.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµ.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÉÌHr ÔÌDWDÒHr¹é€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÉÌHr ÔÌDWDÒHr¹é€......Phase 3A@..DW#DWµ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061242100612421006DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¿.DW% AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDæ Hr ñ DWD~THr¹•ÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDæ Hr ñ DWD~THr¹•Ô......Phase 3A@..DW%DW¿12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1006 10061242100612421006.DW%B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¿.DW% AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDæ Hr ñ DWD~THr¹•ÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDæ Hr ñ DWD~THr¹•Ô......Phase 3A@..DW%DW¿12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1006 10061243100612431006DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¼.DW" AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDŽDHr¡êÄDWD~THrºçTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDŽDHr¡êÄDWD~THrºçT......Phase 3A@..DW"DW¼12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061243100612431006.DW"B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¼.DW" AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDŽDHr¡êÄDWD~THrºçTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDŽDHr¡êÄDWD~THrºçT......Phase 3A@..DW"DW¼12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061244100612441006DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD«Hr¢˜DWD£ Hr» BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD«Hr¢˜DWD£ Hr» ......Phase 3A@..DW"DWµ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1006 10061244100612441006.DW"B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD«Hr¢˜DWD£ Hr» BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD«Hr¢˜DWD£ Hr» ......Phase 3A@..DW"DWµ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1006 10061245100612451006DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD«THr¢ÔDW¨DÓhHsÏhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD«THr¢ÔDWD£\Hr»\DW’Dì¸Hssç¸DW¨DÓhHsÏhPhase 3A@..DW".12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061245100612451006.DW"B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD«THr¢ÔDW¨DÓhHsÏhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD«THr¢ÔDWD£\Hr»\DW’Dì¸Hssç¸DW¨DÓhHsÏhPhase 3A@..DW".12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061245100612451006DW’DW’B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD«THr¢ÔDW¨DÓhHsÏhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD«THr¢ÔDWD£\Hr»\DW’Dì¸Hssç¸DW¨DÓhHsÏhPhase 3A@..DW".12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061245100612451006.DWÅBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW"YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD«THr¢ÔDW¨DÓhHsÏhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD«THr¢ÔDWD£\Hr»\DW’Dì¸Hssç¸DW¨DÓhHsÏhPhase 3A@..DW".12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1006 10061247100612471006DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÉDW$ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóE@Hr¢^DW£DïLHsŠSÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóE@Hr¢^DWD÷¼Hr»`¼DWŽDù`Hsn®`DW£DïLHsŠSÌPhase 3A@....12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061247100612471006.DW$B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÉDW$ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóE@Hr¢^DW£DïLHsŠSÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóE@Hr¢^DWD÷¼Hr»`¼DWŽDù`Hsn®`DW£DïLHsŠSÌPhase 3A@....12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061247100612471006DWŽDWŽBœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÉDW$ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóE@Hr¢^DW£DïLHsŠSÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóE@Hr¢^DWD÷¼Hr»`¼DWŽDù`Hsn®`DW£DïLHsŠSÌPhase 3A@....12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1006 10061247100612471006.DWÉB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÉDW$YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóE@Hr¢^DW£DïLHsŠSÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóE@Hr¢^DWD÷¼Hr»`¼DWŽDù`Hsn®`DW£DïLHsŠSÌPhase 3A@....12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1006 10061248100612481006DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÆDW% AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD$Hr£/$DW¨D‹°Hs‡°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD$Hr£/$DWD’ôHr¼MtDW“D¤HstðDW¨D‹°Hs‡°Phase 3A@..DW%.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061248100612481006.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÆDW% AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD$Hr£/$DW¨D‹°Hs‡°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD$Hr£/$DWD’ôHr¼MtDW“D¤HstðDW¨D‹°Hs‡°Phase 3A@..DW%.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061248100612481006DW“DW“B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÆDW% AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD$Hr£/$DW¨D‹°Hs‡°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD$Hr£/$DWD’ôHr¼MtDW“D¤HstðDW¨D‹°Hs‡°Phase 3A@..DW%.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1006 10061248100612481006.DWÆBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÆDW%YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD$Hr£/$DW¨D‹°Hs‡°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD$Hr£/$DWD’ôHr¼MtDW“D¤HstðDW¨D‹°Hs‡°Phase 3A@..DW%.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1006 10061249100612491006DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¸.DW+ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDš°Hr£H°DWD› Hr½§ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDš°Hr£H°DWD› Hr½§ ......Phase 3A@..DW+DW¸12-15 YearsAYYNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061249100612491006.DW+B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¸.DW+ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDš°Hr£H°DWD› Hr½§ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDš°Hr£H°DWD› Hr½§ ......Phase 3A@..DW+DW¸12-15 YearsAYYNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061250100612501006DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWØDW+ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD›dHr£IdDW»Dõ Hs©þ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW”DW».DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD›dHr£IdDWD›ÜHr½§ÜDW”D‚PHsv PDW»Dõ Hs©þ Phase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061250100612501006.DW+B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWØDW+ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD›dHr£IdDW»Dõ Hs©þ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW”DW».DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD›dHr£IdDWD›ÜHr½§ÜDW”D‚PHsv PDW»Dõ Hs©þ Phase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061250100612501006DW”DW”B¡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWØDW+ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD›dHr£IdDW»Dõ Hs©þ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW”DW».DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD›dHr£IdDWD›ÜHr½§ÜDW”D‚PHsv PDW»Dõ Hs©þ Phase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1006 10061250100612501006.DWØBåOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWØDW+YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD›dHr£IdDW»Dõ Hs©þ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW”DW».DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD›dHr£IdDWD›ÜHr½§ÜDW”D‚PHsv PDW»Dõ Hs©þ Phase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1006 10061252100612521006DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¸.DW$ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôD²˜Hr£`˜DWD¬DHr½¸DBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôD²˜Hr£`˜DWD¬DHr½¸D......Phase 3A@..DW$DW¸12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061252100612521006.DW$B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¸.DW$ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôD²˜Hr£`˜DWD¬DHr½¸DBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôD²˜Hr£`˜DWD¬DHr½¸D......Phase 3A@..DW$DW¸12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061253100612531006DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÅDW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÈdHr£vdDW§D˜ÐHsCPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÈdHr£vdDWD£ Hr¼] DW‘D~Hsr'˜DW§D˜ÐHsCPPhase 3A@..DW(.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061253100612531006.DW(B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÅDW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÈdHr£vdDW§D˜ÐHsCPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÈdHr£vdDWD£ Hr¼] DW‘D~Hsr'˜DW§D˜ÐHsCPPhase 3A@..DW(.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061253100612531006DW‘DW‘BžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÅDW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÈdHr£vdDW§D˜ÐHsCPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÈdHr£vdDWD£ Hr¼] DW‘D~Hsr'˜DW§D˜ÐHsCPPhase 3A@..DW(.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1006 10061253100612531006.DWÅBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÅDW(YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÈdHr£vdDW§D˜ÐHsCPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÈdHr£vdDWD£ Hr¼] DW‘D~Hsr'˜DW§D˜ÐHsCPPhase 3A@..DW(.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1006 10061254100612541006DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÃ.DW) AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÄàHr£ràDWDÇtHr¼ôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÄàHr£ràDWDÇtHr¼ô......Phase 3A@..DW)DWÃ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061254100612541006.DW)B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÃ.DW) AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÄàHr£ràDWDÇtHr¼ôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÄàHr£ràDWDÇtHr¼ô......Phase 3A@..DW)DWÃ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061256100612561006DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÄ.DW( AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDûôHr£©ôDWDî\Hr¼¨ÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDûôHr£©ôDWDî\Hr¼¨Ü......Phase 3A@..DW(DWÄ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061256100612561006.DW(B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÄ.DW( AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDûôHr£©ôDWDî\Hr¼¨ÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDûôHr£©ôDWDî\Hr¼¨Ü......Phase 3A@..DW(DWÄ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061257100612571006DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWkDW$ AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVôDúÈHr£¨ÈDWODÅ”HslPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW:DWO.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDúÈHr£¨ÈDWDäüHr¼Ÿ|DW:Dî\Hrÿå\DWODÅ”HslPhase 3A@..DW$.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSAC4591001C4591001 1006 10061257100612571006.DW$B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWkDW$ AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVôDúÈHr£¨ÈDWODÅ”HslPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW:DWO.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDúÈHr£¨ÈDWDäüHr¼Ÿ|DW:Dî\Hrÿå\DWODÅ”HslPhase 3A@..DW$.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA C4591001C4591001 1006 10061257100612571006DW:DW:BGREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWkDW$ AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVôDúÈHr£¨ÈDWODÅ”HslPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW:DWO.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDúÈHr£¨ÈDWDäüHr¼Ÿ|DW:Dî\Hrÿå\DWODÅ”HslPhase 3A@..DW$.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA0C4591001C4591001 1006 10061257100612571006.DWkBxOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWkDW$YAðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVôDúÈHr£¨ÈDWODÅ”HslPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW:DWO.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDúÈHr£¨ÈDWDäüHr¼Ÿ|DW:Dî\Hrÿå\DWODÅ”HslPhase 3A@..DW$.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA@C4591001C4591001 1006 10061258100612581006DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÆ.DW/ AàYEARSMANATIVE HAWAIIAN OR OTHER PACIFIC ISLANDERAPNATIVE HAWAIIAN OR OTHER PACIFIC ISLANDERAPYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D‚Hr§$”DW D}ÜHrÄ!\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D‚Hr§$”DW D}ÜHrÄ!\......Phase 3A@..DW/DWÆ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1006 10061258100612581006.DW/B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÆ.DW/ AàYEARSMANATIVE HAWAIIAN OR OTHER PACIFIC ISLANDERAPNATIVE HAWAIIAN OR OTHER PACIFIC ISLANDERAPYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D‚Hr§$”DW D}ÜHrÄ!\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D‚Hr§$”DW D}ÜHrÄ!\......Phase 3A@..DW/DWÆ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1006 10061259100612591006DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DW‹DW) AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D–xHr§8øDWoD„lHsEZìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DWVDWo.DW@Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D–xHr§8øDW D¬HrÄ3,DWVD‡´Hs$h´DWoD„lHsEZìPhase 3A@..DW).12-15 YearsA YNN. DW?DWýDWýAðYEARSDSAC4591001C4591001 1006 10061259100612591006.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW‹DW) AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D–xHr§8øDWoD„lHsEZìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DWVDWo.DW@Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D–xHr§8øDW D¬HrÄ3,DWVD‡´Hs$h´DWoD„lHsEZìPhase 3A@..DW).12-15 YearsA YNN. DW?DWýDWýAðYEARSDSA C4591001C4591001 1006 10061259100612591006DWVDWVB`REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW‹DW) AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D–xHr§8øDWoD„lHsEZìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DWVDWo.DW@Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D–xHr§8øDW D¬HrÄ3,DWVD‡´Hs$h´DWoD„lHsEZìPhase 3A@..DW).12-15 YearsA YNN. DW?DWýDWýAðYEARSDSA0C4591001C4591001 1006 10061259100612591006.DW‹B•OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW‹DW)YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D–xHr§8øDWoD„lHsEZìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DWVDWo.DW@Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D–xHr§8øDW D¬HrÄ3,DWVD‡´Hs$h´DWoD„lHsEZìPhase 3A@..DW).12-15 YearsA YNN. DW?DWýDWýAðYEARSDSA@C4591001C4591001 1006 10061260100612601006DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÆDW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D–ðHr§9pDW¦Dš8Hsó8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D–ðHr§9pDW DèHrÄ3hDW‘D‡´Hsr14DW¦Dš8Hsó8Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1006 10061260100612601006.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÆDW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D–ðHr§9pDW¦Dš8Hsó8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D–ðHr§9pDW DèHrÄ3hDW‘D‡´Hsr14DW¦Dš8Hsó8Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1006 10061260100612601006DW‘DW‘B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÆDW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D–ðHr§9pDW¦Dš8Hsó8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D–ðHr§9pDW DèHrÄ3hDW‘D‡´Hsr14DW¦Dš8Hsó8Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1006 10061260100612601006.DWÆBÐOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÆDW)YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D–ðHr§9pDW¦Dš8Hsó8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D–ðHr§9pDW DèHrÄ3hDW‘D‡´Hsr14DW¦Dš8Hsó8Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1006 10061261100612611006DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW½.DW) AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dß Hr§ DW D$HrÄ3¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dß Hr§ DW D$HrÄ3¤......Phase 3A@..DW)DW½12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061261100612611006.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW½.DW) AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dß Hr§ DW D$HrÄ3¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dß Hr§ DW D$HrÄ3¤......Phase 3A@..DW)DW½12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061262100612621006DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWçDW0 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DøpHr§šðDWÄD”\Hsµz\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW™DWÄ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DøpHr§šðDWDá<HrÅÖ<DW™DøèHs}.hDWÄD”\Hsµz\Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061262100612621006.DW0B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWçDW0 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DøpHr§šðDWÄD”\Hsµz\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW™DWÄ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DøpHr§šðDWDá<HrÅÖ<DW™DøèHs}.hDWÄD”\Hsµz\Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061262100612621006DW™DW™B£REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWçDW0 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DøpHr§šðDWÄD”\Hsµz\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW™DWÄ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DøpHr§šðDWDá<HrÅÖ<DW™DøèHs}.hDWÄD”\Hsµz\Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061262100612621006.DWçBñOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWçDW0YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DøpHr§šðDWÄD”\Hsµz\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW™DWÄ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DøpHr§šðDWDá<HrÅÖ<DW™DøèHs}.hDWÄD”\Hsµz\Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1006 10061263100612631006DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DöHr§˜˜DWDî\HrÃ@\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DöHr§˜˜DWDî\HrÃ@\......Phase 3A@..DW,DWÄ12-15 YearsAYYNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1006 10061263100612631006.DW,B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DöHr§˜˜DWDî\HrÃ@\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DöHr§˜˜DWDî\HrÃ@\......Phase 3A@..DW,DWÄ12-15 YearsAYYNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1006 10061264100612641006DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÃ.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dý Hr§Ÿ DWDöHrÃHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dý Hr§Ÿ DWDöHrÃH......Phase 3A@..DW*DWÃ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061264100612641006.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÃ.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dý Hr§Ÿ DWDöHrÃHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dý Hr§Ÿ DWDöHrÃH......Phase 3A@..DW*DWÃ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061265100612651006DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDŒ Hr¬u DWD{HrÅpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDŒ Hr¬u DWD{HrÅp......Phase 3A@DWŽ.DW+.12-15 YearsAYYNN. DWDWŽDWŽAÐYEARSDSAC4591001C4591001 1006 10061265100612651006.DW+B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDŒ Hr¬u DWD{HrÅpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDŒ Hr¬u DWD{HrÅp......Phase 3A@DWŽ.DW+.12-15 YearsAYYNN. DWDWŽDWŽAÐYEARSDSA C4591001C4591001 1006 10061265100612651006.DWŽB”FOLLOW-UP BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABRECEIVED COVID VACCINE OUTSIDE STUDY DW+..DW+YAÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDŒ Hr¬u DWD{HrÅpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDŒ Hr¬u DWD{HrÅp......Phase 3A@DWŽ.DW+.12-15 YearsAYYNN. DWDWŽDWŽAÐYEARSDSAPC4591001C4591001 1006 10061266100612661006DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWpDW1 AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVøDž4Hr¨’4DWTDštHs!ØtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW?DWT.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDž4Hr¨’4DWD›dHrÅdDW?DžèHs-hDWTDštHs!ØtPhase 3A@..DW1.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSAC4591001C4591001 1006 10061266100612661006.DW1B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWpDW1 AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVøDž4Hr¨’4DWTDštHs!ØtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW?DWT.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDž4Hr¨’4DWD›dHrÅdDW?DžèHs-hDWTDštHs!ØtPhase 3A@..DW1.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA C4591001C4591001 1006 10061266100612661006DW?DW?BHREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWpDW1 AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVøDž4Hr¨’4DWTDštHs!ØtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW?DWT.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDž4Hr¨’4DWD›dHrÅdDW?DžèHs-hDWTDštHs!ØtPhase 3A@..DW1.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA0C4591001C4591001 1006 10061266100612661006.DWpByOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWpDW1YAðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVøDž4Hr¨’4DWTDštHs!ØtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW?DWT.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDž4Hr¨’4DWD›dHrÅdDW?DžèHs-hDWTDštHs!ØtPhase 3A@..DW1.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA@C4591001C4591001 1006 10061267100612671006DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:..DW: AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVøD¼¬Hr¨°¬DWéDÝ¸Hsæ‹8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWÒDWé.DWÒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD¼¬Hr¨°¬DWD¬HrÚœ¬DWÒDøpHsÈSpDWéDÝ¸Hsæ‹8Phase 3A@..DW:.12-15 YearsA YNN. DWÑDWýDWýAðYEARSDSAC4591001C4591001 1006 10061267100612671006.DW:BCVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:..DW: AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVøD¼¬Hr¨°¬DWéDÝ¸Hsæ‹8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWÒDWé.DWÒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD¼¬Hr¨°¬DWD¬HrÚœ¬DWÒDøpHsÈSpDWéDÝ¸Hsæ‹8Phase 3A@..DW:.12-15 YearsA YNN. DWÑDWýDWýAðYEARSDSA C4591001C4591001 1006 10061267100612671006DWÒDWÒBÛREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW:..DW: AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVøD¼¬Hr¨°¬DWéDÝ¸Hsæ‹8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWÒDWé.DWÒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD¼¬Hr¨°¬DWD¬HrÚœ¬DWÒDøpHsÈSpDWéDÝ¸Hsæ‹8Phase 3A@..DW:.12-15 YearsA YNN. DWÑDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061269100612691006DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DW¼.DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD÷€Hr¨ë€DWDåìHrÅÚìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD÷€Hr¨ë€DWDåìHrÅÚì......Phase 3A@..DW1DW¼12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061269100612691006.DW1B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DW¼.DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD÷€Hr¨ë€DWDåìHrÅÚìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD÷€Hr¨ë€DWDåìHrÅÚì......Phase 3A@..DW1DW¼12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061270100612701006DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWkDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD™ÀHr©ß@DWNDèHs=Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW9DWN.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD™ÀHr©ß@DWDTHrÅ‚TDW9D‰XHrþ.ØDWNDèHs=Phase 3A@..DW*.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSAC4591001C4591001 1006 10061270100612701006.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWkDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD™ÀHr©ß@DWNDèHs=Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW9DWN.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD™ÀHr©ß@DWDTHrÅ‚TDW9D‰XHrþ.ØDWNDèHs=Phase 3A@..DW*.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA C4591001C4591001 1006 10061270100612701006DW9DW9BAREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWkDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD™ÀHr©ß@DWNDèHs=Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW9DWN.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD™ÀHr©ß@DWDTHrÅ‚TDW9D‰XHrþ.ØDWNDèHs=Phase 3A@..DW*.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA0C4591001C4591001 1006 10061270100612701006.DWkBsOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWkDW*YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD™ÀHr©ß@DWNDèHs=Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW9DWN.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD™ÀHr©ß@DWDTHrÅ‚TDW9D‰XHrþ.ØDWNDèHs=Phase 3A@..DW*.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA@C4591001C4591001 1006 10061271100612711006DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÄ.DW* AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¥´Hr©ë4DW DÊøHrÄnxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¥´Hr©ë4DW DÊøHrÄnx......Phase 3A@..DW*DWÄ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061271100612711006.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÄ.DW* AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¥´Hr©ë4DW DÊøHrÄnxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¥´Hr©ë4DW DÊøHrÄnx......Phase 3A@..DW*DWÄ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061272100612721006DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DW½.DW/ AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDªdHr©ïäDW‘DêœHsr”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVù.DW‘...DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDªdHr©ïäDW‘DêœHsr”......Phase 3A@..DW/DW½12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061272100612721006.DW´B¼VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DW½.DW/ AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDªdHr©ïäDW‘DêœHsr”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVù.DW‘...DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDªdHr©ïäDW‘DêœHsr”......Phase 3A@..DW/DW½12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061273100612731006DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDâ,Hrª'¬DW©DïLHs’<ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW’DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDâ,Hrª'¬DWDÒHrÈjDW’DÖ°HssÑ°DW©DïLHs’<ÌPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061273100612731006.DW,B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDâ,Hrª'¬DW©DïLHs’<ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW’DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDâ,Hrª'¬DWDÒHrÈjDW’DÖ°HssÑ°DW©DïLHs’<ÌPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061273100612731006DW’DW’BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDâ,Hrª'¬DW©DïLHs’<ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW’DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDâ,Hrª'¬DWDÒHrÈjDW’DÖ°HssÑ°DW©DïLHs’<ÌPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1006 10061273100612731006.DWÅBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW,YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDâ,Hrª'¬DW©DïLHs’<ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW’DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDâ,Hrª'¬DWDÒHrÈjDW’DÖ°HssÑ°DW©DïLHs’<ÌPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1006 10061274100612741006DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDúPHrª?ÐDWD™ÀHrÈ1ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDúPHrª?ÐDWD™ÀHrÈ1À......Phase 3A@..DW,DWÄ12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061274100612741006.DW,B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDúPHrª?ÐDWD™ÀHrÈ1ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDúPHrª?ÐDWD™ÀHrÈ1À......Phase 3A@..DW,DWÄ12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061276100612761006DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÑDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD´ðHr«KðDWµD“¨Hs¡³(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW“DWµ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD´ðHr«KðDWDá´HrÅÖ´DW“Dƒ¸HstÐ8DWµD“¨Hs¡³(Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061276100612761006.DW,B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÑDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD´ðHr«KðDWµD“¨Hs¡³(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW“DWµ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD´ðHr«KðDWDá´HrÅÖ´DW“Dƒ¸HstÐ8DWµD“¨Hs¡³(Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061276100612761006DW“DW“BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÑDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD´ðHr«KðDWµD“¨Hs¡³(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW“DWµ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD´ðHr«KðDWDá´HrÅÖ´DW“Dƒ¸HstÐ8DWµD“¨Hs¡³(Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061276100612761006.DWÑBØOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÑDW,YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD´ðHr«KðDWµD“¨Hs¡³(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW“DWµ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD´ðHr«KðDWDá´HrÅÖ´DW“Dƒ¸HstÐ8DWµD“¨Hs¡³(Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1006 10061277100612771006DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÅDW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÙøHr«pøDW¦Dß HsŽ8 Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÙøHr«pøDWDØHrÈpDW’D¥Hss DW¦Dß HsŽ8 Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061277100612771006.DW/B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÅDW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÙøHr«pøDW¦Dß HsŽ8 Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÙøHr«pøDWDØHrÈpDW’D¥Hss DW¦Dß HsŽ8 Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061277100612771006DW’DW’B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÅDW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÙøHr«pøDW¦Dß HsŽ8 Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÙøHr«pøDWDØHrÈpDW’D¥Hss DW¦Dß HsŽ8 Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1006 10061277100612771006.DWÅBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÅDW/YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÙøHr«pøDW¦Dß HsŽ8 Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÙøHr«pøDWDØHrÈpDW’D¥Hss DW¦Dß HsŽ8 Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1006 10061278100612781006DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¿.DW) AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDñ¤Hr«ˆ¤DW D«HrÄOBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DW¾BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDñ¤Hr«ˆ¤DW D«HrÄO......Phase 3A@..DW)DW¿12-15 YearsA YNY. DW½DWýDWýAÐYEARSDSAC4591001C4591001 1006 10061278100612781006.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¿.DW) AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDñ¤Hr«ˆ¤DW D«HrÄOBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DW¾BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDñ¤Hr«ˆ¤DW D«HrÄO......Phase 3A@..DW)DW¿12-15 YearsA YNY. DW½DWýDWýAÐYEARSDSA C4591001C4591001 1006 10061279100612791006DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÅDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDöTHr«TDW¦DñàHsŽJàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDöTHr«TDW DôtHrÄ—ôDW‘D™HHsrBÈDW¦DñàHsŽJàPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061279100612791006.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÅDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDöTHr«TDW¦DñàHsŽJàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDöTHr«TDW DôtHrÄ—ôDW‘D™HHsrBÈDW¦DñàHsŽJàPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061279100612791006DW‘DW‘B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÅDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDöTHr«TDW¦DñàHsŽJàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDöTHr«TDW DôtHrÄ—ôDW‘D™HHsrBÈDW¦DñàHsŽJàPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1006 10061279100612791006.DWÅBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÅDW)YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDöTHr«TDW¦DñàHsŽJàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDöTHr«TDW DôtHrÄ—ôDW‘D™HHsrBÈDW¦DñàHsŽJàPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1006 10061280100612801006DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÃ.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDø¬Hr«¬DWDïÄHrÇ6DBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDø¬Hr«¬DWDïÄHrÇ6D......Phase 3A@DWÞ.DW1DWÃ12-15 YearsAYYNY. DWDWÞDWÞAðYEARSDSAC4591001C4591001 1006 10061280100612801006.DW1B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÃ.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDø¬Hr«¬DWDïÄHrÇ6DBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDø¬Hr«¬DWDïÄHrÇ6D......Phase 3A@DWÞ.DW1DWÃ12-15 YearsAYYNY. DWDWÞDWÞAðYEARSDSA C4591001C4591001 1006 10061280100612801006.DWÞBåFOLLOW-UP BDISPOSITION EVENTOTHER Apenrolled in C4591031 DW1DWÃ.DW1YAðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDø¬Hr«¬DWDïÄHrÇ6DBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDø¬Hr«¬DWDïÄHrÇ6D......Phase 3A@DWÞ.DW1DWÃ12-15 YearsAYYNY. DWDWÞDWÞAðYEARSDSAPC4591001C4591001 1006 10061282100612821006DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DW¿.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD£\Hr¬‹ÜDWDštHrÈ2tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD£\Hr¬‹ÜDWDštHrÈ2t......Phase 3A@..DW3DW¿12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061282100612821006.DW3B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DW¿.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD£\Hr¬‹ÜDWDštHrÈ2tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD£\Hr¬‹ÜDWDštHrÈ2t......Phase 3A@..DW3DW¿12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061283100612831006DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD¯PHr¬—ÐDW©DÅ”Hs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD¯PHr¬—ÐDWDØHrÈpDW”DðxHsvŽxDW©DÅ”Hs’Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061283100612831006.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD¯PHr¬—ÐDW©DÅ”Hs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD¯PHr¬—ÐDWDØHrÈpDW”DðxHsvŽxDW©DÅ”Hs’Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1006 10061283100612831006DW”DW”BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD¯PHr¬—ÐDW©DÅ”Hs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD¯PHr¬—ÐDWDØHrÈpDW”DðxHsvŽxDW©DÅ”Hs’Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061283100612831006.DWÅBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW,YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD¯PHr¬—ÐDW©DÅ”Hs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD¯PHr¬—ÐDWDØHrÈpDW”DðxHsvŽxDW©DÅ”Hs’Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1006 10061284100612841006DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÌDW, AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD÷€Hr¬àDW®DàLHs˜ÅLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW™DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD÷€Hr¬àDWDí0HrÈ…0DW™D$Hs|¶¤DW®DàLHs˜ÅLPhase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061284100612841006.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÌDW, AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD÷€Hr¬àDW®DàLHs˜ÅLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW™DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD÷€Hr¬àDWDí0HrÈ…0DW™D$Hs|¶¤DW®DàLHs˜ÅLPhase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061284100612841006DW™DW™BŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÌDW, AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD÷€Hr¬àDW®DàLHs˜ÅLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW™DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD÷€Hr¬àDWDí0HrÈ…0DW™D$Hs|¶¤DW®DàLHs˜ÅLPhase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1006 10061284100612841006.DWÌBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÌDW,YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD÷€Hr¬àDW®DàLHs˜ÅLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW™DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD÷€Hr¬àDWDí0HrÈ…0DW™D$Hs|¶¤DW®DàLHs˜ÅLPhase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1006 10061285100612851006DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWØDW7 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¨„Hr°…„DWµDÃ´Hs¡ã4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW¢DWµ.DW¡Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¨„Hr°…„DWDépHrÍÇpDW¢DpHsˆ¢pDWµDÃ´Hs¡ã4Phase 3A@..DW7.12-15 YearsA YNN. DW DWýDWýAàYEARSDSAC4591001C4591001 1006 10061285100612851006.DW7B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWØDW7 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¨„Hr°…„DWµDÃ´Hs¡ã4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW¢DWµ.DW¡Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¨„Hr°…„DWDépHrÍÇpDW¢DpHsˆ¢pDWµDÃ´Hs¡ã4Phase 3A@..DW7.12-15 YearsA YNN. DW DWýDWýAàYEARSDSA C4591001C4591001 1006 10061285100612851006DW¢DW¢B¥REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWØDW7 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¨„Hr°…„DWµDÃ´Hs¡ã4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW¢DWµ.DW¡Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¨„Hr°…„DWDépHrÍÇpDW¢DpHsˆ¢pDWµDÃ´Hs¡ã4Phase 3A@..DW7.12-15 YearsA YNN. DW DWýDWýAàYEARSDSA0C4591001C4591001 1006 10061285100612851006.DWØBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWØDW7YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¨„Hr°…„DWµDÃ´Hs¡ã4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW¢DWµ.DW¡Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¨„Hr°…„DWDépHrÍÇpDW¢DpHsˆ¢pDWµDÃ´Hs¡ã4Phase 3A@..DW7.12-15 YearsA YNN. DW DWýDWýAàYEARSDSA@C4591001C4591001 1006 10061286100612861006DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÉ.DW0 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÊøHr°§øDWDìôHrÌytBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÊøHr°§øDWDìôHrÌyt......Phase 3A@..DW0DWÉ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1006 10061286100612861006.DW0B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÉ.DW0 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÊøHr°§øDWDìôHrÌytBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÊøHr°§øDWDìôHrÌyt......Phase 3A@..DW0DWÉ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1006 10061287100612871006DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDâàHr°¿àDWD÷øHrÌ„xPlacebo Placebo 12-15 YearsA . . .DVþDW....DWŽPlacebo Placebo Placebo A .Placebo A .DVþDâàHr°¿àDWD÷øHrÌ„x......Phase 3A@DW™.DW/.12-15 YearsA YNN. DWDW™DW™AÐYEARSDSAC4591001C4591001 1006 10061287100612871006.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDâàHr°¿àDWD÷øHrÌ„xPlacebo Placebo 12-15 YearsA . . .DVþDW....DWŽPlacebo Placebo Placebo A .Placebo A .DVþDâàHr°¿àDWD÷øHrÌ„x......Phase 3A@DW™.DW/.12-15 YearsA YNN. DWDW™DW™AÐYEARSDSA C4591001C4591001 1006 10061287100612871006.DW™BœFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BDiscontinued DW/..DW/YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDâàHr°¿àDWD÷øHrÌ„xPlacebo Placebo 12-15 YearsA . . .DVþDW....DWŽPlacebo Placebo Placebo A .Placebo A .DVþDâàHr°¿àDWD÷øHrÌ„x......Phase 3A@DW™.DW/.12-15 YearsA YNN. DWDW™DW™AÐYEARSDSApC4591001C4591001 1006 10061288100612881006DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÐ.DW/ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDãHr°ÀDWD÷¼HrÌ„<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW@BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDãHr°ÀDWD÷¼HrÌ„<......Phase 3A@DWÞ.DW/DWÐ12-15 YearsA YNY. DW?DWÞDWÞAðYEARSDSAC4591001C4591001 1006 10061288100612881006.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÐ.DW/ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDãHr°ÀDWD÷¼HrÌ„<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW@BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDãHr°ÀDWD÷¼HrÌ„<......Phase 3A@DWÞ.DW/DWÐ12-15 YearsA YNY. DW?DWÞDWÞAðYEARSDSA C4591001C4591001 1006 10061288100612881006.DWÞBáFOLLOW-UP BDISPOSITION EVENTOTHER Apenrolled in C4591031 DW/DWÐ.DW/YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDãHr°ÀDWD÷¼HrÌ„<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW@BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDãHr°ÀDWD÷¼HrÌ„<......Phase 3A@DWÞ.DW/DWÐ12-15 YearsA YNY. DW?DWÞDWÞAðYEARSDSA@C4591001C4591001 1006 10061289100612891006DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÑ.DW6 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD‚ÈHr±±HDWDì|HrÏüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD‚ÈHr±±HDWDì|HrÏü......Phase 3A@..DW6DWÑ12-15 YearsA YNY. DW”DWýDWýAÐYEARSDSAC4591001C4591001 1006 10061289100612891006.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÑ.DW6 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD‚ÈHr±±HDWDì|HrÏüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD‚ÈHr±±HDWDì|HrÏü......Phase 3A@..DW6DWÑ12-15 YearsA YNY. DW”DWýDWýAÐYEARSDSA C4591001C4591001 1006 10061290100612901006DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÑ.DW6 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDƒHr±±„DWDì¸HrÏ8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDƒHr±±„DWDì¸HrÏ8......Phase 3A@..DW6DWÑ12-15 YearsA YNY. DW”DWýDWýAðYEARSDSAC4591001C4591001 1006 10061290100612901006.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÑ.DW6 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDƒHr±±„DWDì¸HrÏ8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDƒHr±±„DWDì¸HrÏ8......Phase 3A@..DW6DWÑ12-15 YearsA YNY. DW”DWýDWýAðYEARSDSA C4591001C4591001 1006 10061291100612911006DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÊDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDƒ@Hr±±ÀDWDêØHs—~XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW˜DW.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDƒ@Hr±±ÀDWDìôHrÏtDW˜Dô°Hs{Ø°DWDêØHs—~XPhase 3A@..DW6.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSAC4591001C4591001 1006 10061291100612911006.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÊDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDƒ@Hr±±ÀDWDêØHs—~XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW˜DW.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDƒ@Hr±±ÀDWDìôHrÏtDW˜Dô°Hs{Ø°DWDêØHs—~XPhase 3A@..DW6.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA C4591001C4591001 1006 10061291100612911006DW˜DW˜BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÊDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDƒ@Hr±±ÀDWDêØHs—~XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW˜DW.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDƒ@Hr±±ÀDWDìôHrÏtDW˜Dô°Hs{Ø°DWDêØHs—~XPhase 3A@..DW6.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA0C4591001C4591001 1006 10061291100612911006.DWÊBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÊDW6YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDƒ@Hr±±ÀDWDêØHs—~XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW˜DW.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDƒ@Hr±±ÀDWDìôHrÏtDW˜Dô°Hs{Ø°DWDêØHs—~XPhase 3A@..DW6.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA@C4591001C4591001 1006 10061292100612921006DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW½DW1 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÃ<Hr±ñ¼DW¡DøHs‡AxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÃ<Hr±ñ¼DWD‚ŒHrÍ`ŒDWŽDƒ|Hsn8|DW¡DøHs‡AxPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1006 10061292100612921006.DW1B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW½DW1 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÃ<Hr±ñ¼DW¡DøHs‡AxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÃ<Hr±ñ¼DWD‚ŒHrÍ`ŒDWŽDƒ|Hsn8|DW¡DøHs‡AxPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1006 10061292100612921006DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW½DW1 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÃ<Hr±ñ¼DW¡DøHs‡AxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÃ<Hr±ñ¼DWD‚ŒHrÍ`ŒDWŽDƒ|Hsn8|DW¡DøHs‡AxPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1006 10061292100612921006.DW½B¿OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW½DW1YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÃ<Hr±ñ¼DW¡DøHs‡AxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÃ<Hr±ñ¼DWD‚ŒHrÍ`ŒDWŽDƒ|Hsn8|DW¡DøHs‡AxPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1006 10061293100612931006DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÃHr±ñ€DWD‚ÈHrÍ`ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÃHr±ñ€DWD‚ÈHrÍ`È......Phase 3A@..DW1DWË12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1006 10061293100612931006.DW1B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÃHr±ñ€DWD‚ÈHrÍ`ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÃHr±ñ€DWD‚ÈHrÍ`È......Phase 3A@..DW1DWË12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1006 10061294100612941006DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÅDW0 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDëHr²”DW§DçHs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDëHr²”DWDÔ”HrÍ²”DW”DÉHsvgDW§DçHs’Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061294100612941006.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÅDW0 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDëHr²”DW§DçHs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDëHr²”DWDÔ”HrÍ²”DW”DÉHsvgDW§DçHs’Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061294100612941006DW”DW”B–REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÅDW0 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDëHr²”DW§DçHs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDëHr²”DWDÔ”HrÍ²”DW”DÉHsvgDW§DçHs’Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1006 10061294100612941006.DWÅBÇOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÅDW0YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDëHr²”DW§DçHs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDëHr²”DWDÔ”HrÍ²”DW”DÉHsvgDW§DçHs’Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1006 10061295100612951006DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW½DW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‘ŒHr´cDW¡D€4Hs‡A´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‘ŒHr´cDWDƒHrÍaDWŽDƒ¸Hsn8¸DW¡D€4Hs‡A´Phase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1006 10061295100612951006.DW1B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW½DW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‘ŒHr´cDW¡D€4Hs‡A´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‘ŒHr´cDWDƒHrÍaDWŽDƒ¸Hsn8¸DW¡D€4Hs‡A´Phase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1006 10061295100612951006DWŽDWŽBŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW½DW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‘ŒHr´cDW¡D€4Hs‡A´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‘ŒHr´cDWDƒHrÍaDWŽDƒ¸Hsn8¸DW¡D€4Hs‡A´Phase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1006 10061295100612951006.DW½B½OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW½DW1YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‘ŒHr´cDW¡D€4Hs‡A´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‘ŒHr´cDWDƒHrÍaDWŽDƒ¸Hsn8¸DW¡D€4Hs‡A´Phase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1006 10061296100612961006DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‹8Hrºô8DWDáðHrÖúpPlacebo Placebo 12-15 YearsA . . .DWDW....DW›Placebo Placebo Placebo A .Placebo A .DWD‹8Hrºô8DWDáðHrÖúp......Phase 3A@DW›.DW7.12-15 YearsA YNN. DWšDW›DW›AàYEARSDSAC4591001C4591001 1006 10061296100612961006.DW7B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‹8Hrºô8DWDáðHrÖúpPlacebo Placebo 12-15 YearsA . . .DWDW....DW›Placebo Placebo Placebo A .Placebo A .DWD‹8Hrºô8DWDáðHrÖúp......Phase 3A@DW›.DW7.12-15 YearsA YNN. DWšDW›DW›AàYEARSDSA C4591001C4591001 1006 10061296100612961006.DW›B–FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APunable to contact DW7..DW7YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‹8Hrºô8DWDáðHrÖúpPlacebo Placebo 12-15 YearsA . . .DWDW....DW›Placebo Placebo Placebo A .Placebo A .DWD‹8Hrºô8DWDáðHrÖúp......Phase 3A@DW›.DW7.12-15 YearsA YNN. DWšDW›DW›AàYEARSDSAPC4591001C4591001 1006 10061297100612971006DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‹tHrºôtDWDá´HrÖú4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW›BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‹tHrºôtDWDá´HrÖú4......Phase 3A@DW›.DW7.12-15 YearsA YNN. DWšDW›DW›AÀYEARSDSAC4591001C4591001 1006 10061297100612971006.DW7B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‹tHrºôtDWDá´HrÖú4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW›BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‹tHrºôtDWDá´HrÖú4......Phase 3A@DW›.DW7.12-15 YearsA YNN. DWšDW›DW›AÀYEARSDSA C4591001C4591001 1006 10061297100612971006.DW›B–FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APunable to contact DW7..DW7YAÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‹tHrºôtDWDá´HrÖú4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW›BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‹tHrºôtDWDá´HrÖú4......Phase 3A@DW›.DW7.12-15 YearsA YNN. DWšDW›DW›AÀYEARSDSAPC4591001C4591001 1006 10061298100612981006DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÆDW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐÔHr»9ÔDW¨D‰ÐHs…ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐÔHr»9ÔDWD¶HrØ DW“D’@HstÞÀDW¨D‰ÐHs…ÐPhase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1006 10061298100612981006.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÆDW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐÔHr»9ÔDW¨D‰ÐHs…ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐÔHr»9ÔDWD¶HrØ DW“D’@HstÞÀDW¨D‰ÐHs…ÐPhase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1006 10061298100612981006DW“DW“BŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÆDW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐÔHr»9ÔDW¨D‰ÐHs…ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐÔHr»9ÔDWD¶HrØ DW“D’@HstÞÀDW¨D‰ÐHs…ÐPhase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1006 10061298100612981006.DWÆBÁOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÆDW8YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐÔHr»9ÔDW¨D‰ÐHs…ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐÔHr»9ÔDWD¶HrØ DW“D’@HstÞÀDW¨D‰ÐHs…ÐPhase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1006 10061299100612991006DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÍ.DW? AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¤LHr½°LDWDð´HrÚý´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¤LHr½°LDWDð´HrÚý´......Phase 3A@..DW?DWÍ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1006 10061299100612991006.DW?B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÍ.DW? AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¤LHr½°LDWDð´HrÚý´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¤LHr½°LDWDð´HrÚý´......Phase 3A@..DW?DWÍ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1006 10061300100613001006DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÓ.DWA AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDêœHrÇ1DW$Dè¼HrâÞ¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDêœHrÇ1DW$Dè¼HrâÞ¼......Phase 3A@..DWADWÓ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1006 10061300100613001006.DWAB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÓ.DWA AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDêœHrÇ1DW$Dè¼HrâÞ¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDêœHrÇ1DW$Dè¼HrâÞ¼......Phase 3A@..DWADWÓ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1007 10071409100714091007DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVøDWŠ.DVø AÐYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂD¡|Hrad|DW›D–Hsn€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂ.DW›...DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂD¡|Hrad|DW›D–Hsn€......Phase 3A@..DVøDWŠ12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1007 10071409100714091007.DW¾BýVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVøDWŠ.DVø AÐYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂD¡|Hrad|DW›D–Hsn€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂ.DW›...DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂD¡|Hrad|DW›D–Hsn€......Phase 3A@..DVøDWŠ12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1007 10071414100714141007DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†DWÉDVó AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD¬¼Hrao¼DWDÍÈHs—aHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDV×.DW“DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂD¬¼Hrao¼DV×D¸°Hr}+0DW“D·üHsu|DWDÍÈHs—aHPhase 3A@..DVóDW†12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071414100714141007.DVóB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†DWÉDVó AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD¬¼Hrao¼DWDÍÈHs—aHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDV×.DW“DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂD¬¼Hrao¼DV×D¸°Hr}+0DW“D·üHsu|DWDÍÈHs—aHPhase 3A@..DVóDW†12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071414100714141007DW“DW“BÒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†DWÉDVó AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD¬¼Hrao¼DWDÍÈHs—aHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDV×.DW“DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂD¬¼Hrao¼DV×D¸°Hr}+0DW“D·üHsu|DWDÍÈHs—aHPhase 3A@..DVóDW†12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071414100714141007.DWÉC€OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†DWÉDVóYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD¬¼Hrao¼DWDÍÈHs—aHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDV×.DW“DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂD¬¼Hrao¼DV×D¸°Hr}+0DW“D·üHsu|DWDÍÈHs—aHPhase 3A@..DVóDW†12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071415100714151007DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¦.DW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD¶HrayDVóDœHr¡ÞPlacebo Placebo 12-15 YearsA . . .DVÂDVó....DWŒPlacebo Placebo Placebo A .Placebo A .DVÂD¶HrayDVóDœHr¡Þ......Phase 3A@..DWDW¦12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071415100714151007.DWBNVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¦.DW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD¶HrayDVóDœHr¡ÞPlacebo Placebo 12-15 YearsA . . .DVÂDVó....DWŒPlacebo Placebo Placebo A .Placebo A .DVÂD¶HrayDVóDœHr¡Þ......Phase 3A@..DWDW¦12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071417100714171007DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†.DVó AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂD¾PHraPDV×D°ôHr}#tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDV×....DW@BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂD¾PHraPDV×D°ôHr}#t......Phase 3A@..DVóDW†12-15 YearsAYYNY. DW?DWýDWýAðYEARSDSAC4591001C4591001 1007 10071417100714171007.DVóB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†.DVó AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂD¾PHraPDV×D°ôHr}#tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDV×....DW@BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂD¾PHraPDV×D°ôHr}#t......Phase 3A@..DVóDW†12-15 YearsAYYNY. DW?DWýDWýAðYEARSDSA C4591001C4591001 1007 10071428100714281007DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DV÷DWŠ.DV÷ AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVÂDå°Hra¨°DV×DçHr}Y˜Placebo Placebo 12-15 YearsA . . .DVÂDV×....DWPlacebo Placebo Placebo A .Placebo A .DVÂDå°Hra¨°DV×DçHr}Y˜......Phase 3A@..DV÷DWŠ12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071428100714281007.DV÷B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DWŠ.DV÷ AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVÂDå°Hra¨°DV×DçHr}Y˜Placebo Placebo 12-15 YearsA . . .DVÂDV×....DWPlacebo Placebo Placebo A .Placebo A .DVÂDå°Hra¨°DV×DçHr}Y˜......Phase 3A@..DV÷DWŠ12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071429100714291007DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVóDWŠ.DVó AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDèøHra«øDV×Dê`Hr}\àPlacebo Placebo 12-15 YearsA . . .DVÂDV×....DWŒPlacebo Placebo Placebo A .Placebo A .DVÂDèøHra«øDV×Dê`Hr}\à......Phase 3A@..DVóDWŠ12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071429100714291007.DVóB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVóDWŠ.DVó AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDèøHra«øDV×Dê`Hr}\àPlacebo Placebo 12-15 YearsA . . .DVÂDV×....DWŒPlacebo Placebo Placebo A .Placebo A .DVÂDèøHra«øDV×Dê`Hr}\à......Phase 3A@..DVóDWŠ12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071467100714671007DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD’¸Hr”À8DVþDŒdHr°idBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWSBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD’¸Hr”À8DVþDŒdHr°id......Phase 3A@..DWDW12-15 YearsAYYNY. DWRDWýDWýAðYEARSDSAC4591001C4591001 1007 10071467100714671007.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD’¸Hr”À8DVþDŒdHr°idBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWSBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD’¸Hr”À8DVþDŒdHr°id......Phase 3A@..DWDW12-15 YearsAYYNY. DWRDWýDWýAðYEARSDSA C4591001C4591001 1007 10071469100714691007DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDŸØHr”ÍXDVþDŸØHr°|ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDŸØHr”ÍXDVþDŸØHr°|Ø......Phase 3A@..DWDW´12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1007 10071469100714691007.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDŸØHr”ÍXDVþDŸØHr°|ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDŸØHr”ÍXDVþDŸØHr°|Ø......Phase 3A@..DWDW´12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1007 10071471100714711007DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD®œHr”ÜDVþD¢0Hr°0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD®œHr”ÜDVþD¢0Hr°0......Phase 3A@..DWDW12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071471100714711007.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD®œHr”ÜDVþD¢0Hr°0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD®œHr”ÜDVþD¢0Hr°0......Phase 3A@..DWDW12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071472100714721007DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDÄ,Hr”ñ¬DW¦DÓhHsŽ,hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDÄ,Hr”ñ¬DVþDÌHr°jÌDW‘DµàHsr_`DW¦DÓhHsŽ,hPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071472100714721007.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDÄ,Hr”ñ¬DW¦DÓhHsŽ,hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDÄ,Hr”ñ¬DVþDÌHr°jÌDW‘DµàHsr_`DW¦DÓhHsŽ,hPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071472100714721007DW‘DW‘B©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDÄ,Hr”ñ¬DW¦DÓhHsŽ,hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDÄ,Hr”ñ¬DVþDÌHr°jÌDW‘DµàHsr_`DW¦DÓhHsŽ,hPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071472100714721007.DWÉBáOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDWYAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDÄ,Hr”ñ¬DW¦DÓhHsŽ,hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDÄ,Hr”ñ¬DVþDÌHr°jÌDW‘DµàHsr_`DW¦DÓhHsŽ,hPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071475100714751007DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDÓhHr•èDVþDÎHr°«BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDÓhHr•èDVþDÎHr°«......Phase 3A@..DWDW12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1007 10071475100714751007.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDÓhHr•èDVþDÎHr°«BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDÓhHr•èDVþDÎHr°«......Phase 3A@..DWDW12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1007 10071476100714761007DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDóHHr• ÈDVþD¥´Hr°‚´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDóHHr• ÈDVþD¥´Hr°‚´......Phase 3A@..DWDW12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071476100714761007.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDóHHr• ÈDVþD¥´Hr°‚´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDóHHr• ÈDVþD¥´Hr°‚´......Phase 3A@..DWDW12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071478100714781007DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDïˆHr•DW¨DÅHsÁPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDïˆHr•DVþDäHHr°ÁHDW”DÂLHsv`LDW¨DÅHsÁPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071478100714781007.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDïˆHr•DW¨DÅHsÁPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDïˆHr•DVþDäHHr°ÁHDW”DÂLHsv`LDW¨DÅHsÁPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071478100714781007DW”DW”B¬REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDïˆHr•DW¨DÅHsÁPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDïˆHr•DVþDäHHr°ÁHDW”DÂLHsv`LDW¨DÅHsÁPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071478100714781007.DWÊBâOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDWYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDïˆHr•DW¨DÅHsÁPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDïˆHr•DVþDäHHr°ÁHDW”DÂLHsv`LDW¨DÅHsÁPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071480100714801007DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDóüHr•!|DW§DŸ$HsI¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDóüHr•!|DVþDÕÀHr°²ÀDW‘DÃxHsrløDW§DŸ$HsI¤Phase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071480100714801007.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDóüHr•!|DW§DŸ$HsI¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDóüHr•!|DVþDÕÀHr°²ÀDW‘DÃxHsrløDW§DŸ$HsI¤Phase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071480100714801007DW‘DW‘B©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDóüHr•!|DW§DŸ$HsI¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDóüHr•!|DVþDÕÀHr°²ÀDW‘DÃxHsrløDW§DŸ$HsI¤Phase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071480100714801007.DWÊBâOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDWYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDóüHr•!|DW§DŸ$HsI¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDóüHr•!|DVþDÕÀHr°²ÀDW‘DÃxHsrløDW§DŸ$HsI¤Phase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071481100714811007DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÝDW AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDˆ¤Hr–¤DW»D‰XHs©‘ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW¦DW».DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDˆ¤Hr–¤DVÿDŒ Hr±» DW¦D¡ôHsúôDW»D‰XHs©‘ØPhase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071481100714811007.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÝDW AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDˆ¤Hr–¤DW»D‰XHs©‘ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW¦DW».DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDˆ¤Hr–¤DVÿDŒ Hr±» DW¦D¡ôHsúôDW»D‰XHs©‘ØPhase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071481100714811007DW¦DW¦B½REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÝDW AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDˆ¤Hr–¤DW»D‰XHs©‘ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW¦DW».DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDˆ¤Hr–¤DVÿDŒ Hr±» DW¦D¡ôHsúôDW»D‰XHs©‘ØPhase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071481100714811007.DWÝBôOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÝDWYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDˆ¤Hr–¤DW»D‰XHs©‘ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW¦DW».DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDˆ¤Hr–¤DVÿDŒ Hr±» DW¦D¡ôHsúôDW»D‰XHs©‘ØPhase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071482100714821007DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDWÌ.DW AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÌHr–ÌDVÿD” Hr±Â BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÌHr–ÌDVÿD” Hr±Â ......Phase 3A@..DWDWÌ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071482100714821007.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDWÌ.DW AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÌHr–ÌDVÿD” Hr±Â BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÌHr–ÌDVÿD” Hr±Â ......Phase 3A@..DWDWÌ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071483100714831007DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DW’DW" AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDŸ`Hr–`DWvDÛ$HsNì$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWaDWv.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDŸ`Hr–`DVÿD4Hr±Û´DWaDçÌHs3ILDWvDÛ$HsNì$Phase 3A@..DW".12-15 YearsA YNN. DWJDWýDWýAðYEARSDSAC4591001C4591001 1007 10071483100714831007.DW"B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DW’DW" AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDŸ`Hr–`DWvDÛ$HsNì$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWaDWv.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDŸ`Hr–`DVÿD4Hr±Û´DWaDçÌHs3ILDWvDÛ$HsNì$Phase 3A@..DW".12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA C4591001C4591001 1007 10071483100714831007DWaDWaBxREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DW’DW" AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDŸ`Hr–`DWvDÛ$HsNì$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWaDWv.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDŸ`Hr–`DVÿD4Hr±Û´DWaDçÌHs3ILDWvDÛ$HsNì$Phase 3A@..DW".12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA0C4591001C4591001 1007 10071483100714831007.DW’B©OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DW’DW"YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDŸ`Hr–`DWvDÛ$HsNì$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWaDWv.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDŸ`Hr–`DVÿD4Hr±Û´DWaDçÌHs3ILDWvDÛ$HsNì$Phase 3A@..DW".12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA@C4591001C4591001 1007 10071484100714841007DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÄDW" AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDžpHr–pDW¨Dß HsÛ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDžpHr–pDVÿDèHr±ÜhDW“DÇìHsulDW¨Dß HsÛ Phase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071484100714841007.DW"B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÄDW" AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDžpHr–pDW¨Dß HsÛ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDžpHr–pDVÿDèHr±ÜhDW“DÇìHsulDW¨Dß HsÛ Phase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071484100714841007DW“DW“BªREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÄDW" AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDžpHr–pDW¨Dß HsÛ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDžpHr–pDVÿDèHr±ÜhDW“DÇìHsulDW¨Dß HsÛ Phase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071484100714841007.DWÄBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÄDW"YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDžpHr–pDW¨Dß HsÛ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDžpHr–pDVÿDèHr±ÜhDW“DÇìHsulDW¨Dß HsÛ Phase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071485100714851007DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÅÐHr–DÐDVþDÓ,Hr°°,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVþ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÅÐHr–DÐDVþDÓ,Hr°°,......Phase 3A@..DWDW®12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071485100714851007.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÅÐHr–DÐDVþDÓ,Hr°°,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVþ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÅÐHr–DÐDVþDÓ,Hr°°,......Phase 3A@..DWDW®12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071488100714881007DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDàHr–_DVÿD¨ÀHr±×@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDàHr–_DVÿD¨ÀHr±×@......Phase 3A@..DWDW®12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071488100714881007.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDàHr–_DVÿD¨ÀHr±×@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDàHr–_DVÿD¨ÀHr±×@......Phase 3A@..DWDW®12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071490100714901007DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDí¨Hr–l¨DVÿD¨HHr±ÖÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDí¨Hr–l¨DVÿD¨HHr±ÖÈ......Phase 3A@..DWDW¯12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071490100714901007.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDí¨Hr–l¨DVÿD¨HHr±ÖÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDí¨Hr–l¨DVÿD¨HHr±ÖÈ......Phase 3A@..DWDW¯12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071492100714921007DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW·.DW AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDô8Hr–s8DVþDÝ|Hr°º|Placebo Placebo 12-15 YearsA . . .DVêDVþ....DWŒPlacebo Placebo Placebo A .Placebo A .DVêDô8Hr–s8DVþDÝ|Hr°º|......Phase 3A@..DWDW·12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071492100714921007.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW·.DW AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDô8Hr–s8DVþDÝ|Hr°º|Placebo Placebo 12-15 YearsA . . .DVêDVþ....DWŒPlacebo Placebo Placebo A .Placebo A .DVêDô8Hr–s8DVþDÝ|Hr°º|......Phase 3A@..DWDW·12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071494100714941007DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD¡|Hr—qüDVþDÕHr°²BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD¡|Hr—qüDVþDÕHr°²......Phase 3A@..DWDW´12-15 YearsAYYNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071494100714941007.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD¡|Hr—qüDVþDÕHr°²BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD¡|Hr—qüDVþDÕHr°²......Phase 3A@..DWDW´12-15 YearsAYYNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071495100714951007DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÕüHr—¦|DWD©tHs—<ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW™DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÕüHr—¦|DVÿDÆHr±ôŒDW™DÝ¸Hs}8DWD©tHs—<ôPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071495100714951007.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÕüHr—¦|DWD©tHs—<ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW™DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÕüHr—¦|DVÿDÆHr±ôŒDW™DÝ¸Hs}8DWD©tHs—<ôPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071495100714951007DW™DW™B¯REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÕüHr—¦|DWD©tHs—<ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW™DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÕüHr—¦|DVÿDÆHr±ôŒDW™DÝ¸Hs}8DWD©tHs—<ôPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071495100714951007.DWÊBàOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÊDWYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÕüHr—¦|DWD©tHs—<ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW™DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÕüHr—¦|DVÿDÆHr±ôŒDW™DÝ¸Hs}8DWD©tHs—<ôPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071496100714961007DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVëDñàHr—Â`DWD½ØHs—QXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDñàHr—Â`DVÿD‹°Hr±º0DW˜DÒHs{¶DWD½ØHs—QXPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071496100714961007.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVëDñàHr—Â`DWD½ØHs—QXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDñàHr—Â`DVÿD‹°Hr±º0DW˜DÒHs{¶DWD½ØHs—QXPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071496100714961007DW˜DW˜B®REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVëDñàHr—Â`DWD½ØHs—QXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDñàHr—Â`DVÿD‹°Hr±º0DW˜DÒHs{¶DWD½ØHs—QXPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071496100714961007.DWÉBßOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDWYAàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVëDñàHr—Â`DWD½ØHs—QXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDñàHr—Â`DVÿD‹°Hr±º0DW˜DÒHs{¶DWD½ØHs—QXPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071497100714971007DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDô8Hr—Ä¸DVÿDŠHHr±¸ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDô8Hr—Ä¸DVÿDŠHHr±¸È......Phase 3A@..DWDW¯12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071497100714971007.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDô8Hr—Ä¸DVÿDŠHHr±¸ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDô8Hr—Ä¸DVÿDŠHHr±¸È......Phase 3A@..DWDW¯12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071499100714991007DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW».DW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDåìHr™ìDVÿD×(Hr²¨Placebo Placebo 12-15 YearsA . . .DVìDVÿ....DWŒPlacebo Placebo Placebo A .Placebo A .DVìDåìHr™ìDVÿD×(Hr²¨......Phase 3A@..DWDW»12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071499100714991007.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW».DW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDåìHr™ìDVÿD×(Hr²¨Placebo Placebo 12-15 YearsA . . .DVìDVÿ....DWŒPlacebo Placebo Placebo A .Placebo A .DVìDåìHr™ìDVÿD×(Hr²¨......Phase 3A@..DWDW»12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071500100715001007DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDí¨Hr™¨DVÿD’¸Hr±Á8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDí¨Hr™¨DVÿD’¸Hr±Á8......Phase 3A@..DWDWµ12-15 YearsA YNY. DW=DWýDWýAðYEARSDSAC4591001C4591001 1007 10071500100715001007.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDí¨Hr™¨DVÿD’¸Hr±Á8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDí¨Hr™¨DVÿD’¸Hr±Á8......Phase 3A@..DWDWµ12-15 YearsA YNY. DW=DWýDWýAðYEARSDSA C4591001C4591001 1007 10071504100715041007DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDˆ,Hrð,DWD”ÔHr¼OTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDˆ,Hrð,DWD”ÔHr¼OT......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSAC4591001C4591001 1007 10071504100715041007.DW#B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDˆ,Hrð,DWD”ÔHr¼OTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDˆ,Hrð,DWD”ÔHr¼OT......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSA C4591001C4591001 1007 10071505100715051007DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÓDW( AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD`Hrø`DW¶DÂˆHs£3ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW¡DW¶.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD`Hrø`DWDé¬Hrº,DW¡D¼Hs‡_<DW¶DÂˆHs£3ˆPhase 3A@..DW(.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071505100715051007.DW(B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÓDW( AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD`Hrø`DW¶DÂˆHs£3ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW¡DW¶.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD`Hrø`DWDé¬Hrº,DW¡D¼Hs‡_<DW¶DÂˆHs£3ˆPhase 3A@..DW(.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071505100715051007DW¡DW¡B²REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÓDW( AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD`Hrø`DW¶DÂˆHs£3ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW¡DW¶.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD`Hrø`DWDé¬Hrº,DW¡D¼Hs‡_<DW¶DÂˆHs£3ˆPhase 3A@..DW(.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071505100715051007.DWÓBäOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÓDW(YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD`Hrø`DW¶DÂˆHs£3ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW¡DW¶.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD`Hrø`DWDé¬Hrº,DW¡D¼Hs‡_<DW¶DÂˆHs£3ˆPhase 3A@..DW(.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071506100715061007DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD–xHrþxDWDâ,Hr¹ù¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW}BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD–xHrþxDWDâ,Hr¹ù¬......Phase 3A@..DW!DW´12-15 YearsAYYNY. DW|DWýDWýAðYEARSDSAC4591001C4591001 1007 10071506100715061007.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD–xHrþxDWDâ,Hr¹ù¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW}BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD–xHrþxDWDâ,Hr¹ù¬......Phase 3A@..DW!DW´12-15 YearsAYYNY. DW|DWýDWýAðYEARSDSA C4591001C4591001 1007 10071507100715071007DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÆDW! AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDªdHrždDW©DÇ8Hs’¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDªdHrždDWD¦àHr¹¾`DW“DÀ¨Hsu (DW©DÇ8Hs’¸Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071507100715071007.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÆDW! AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDªdHrždDW©DÇ8Hs’¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDªdHrždDWD¦àHr¹¾`DW“DÀ¨Hsu (DW©DÇ8Hs’¸Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071507100715071007DW“DW“B¤REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÆDW! AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDªdHrždDW©DÇ8Hs’¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDªdHrždDWD¦àHr¹¾`DW“DÀ¨Hsu (DW©DÇ8Hs’¸Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071507100715071007.DWÆB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÆDW!YAÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDªdHrždDW©DÇ8Hs’¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDªdHrždDWD¦àHr¹¾`DW“DÀ¨Hsu (DW©DÇ8Hs’¸Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071508100715081007DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW´.DW$ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÁÔHrž)ÔDWDÁ˜Hr¹ÙBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÁÔHrž)ÔDWDÁ˜Hr¹Ù......Phase 3A@..DW$DW´12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1007 10071508100715081007.DW$B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW´.DW$ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÁÔHrž)ÔDWDÁ˜Hr¹ÙBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÁÔHrž)ÔDWDÁ˜Hr¹Ù......Phase 3A@..DW$DW´12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1007 10071509100715091007DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÎ¸Hrž6¸DW¨D¬€Hs¨€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÎ¸Hrž6¸DWD”ÔHr¼OTDW”Dˆ¤Hsv&¤DW¨D¬€Hs¨€Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071509100715091007.DW#B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÎ¸Hrž6¸DW¨D¬€Hs¨€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÎ¸Hrž6¸DWD”ÔHr¼OTDW”Dˆ¤Hsv&¤DW¨D¬€Hs¨€Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071509100715091007DW”DW”B¥REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÎ¸Hrž6¸DW¨D¬€Hs¨€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÎ¸Hrž6¸DWD”ÔHr¼OTDW”Dˆ¤Hsv&¤DW¨D¬€Hs¨€Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071509100715091007.DWÄBÕOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW#YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÎ¸Hrž6¸DW¨D¬€Hs¨€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÎ¸Hrž6¸DWD”ÔHr¼OTDW”Dˆ¤Hsv&¤DW¨D¬€Hs¨€Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071511100715111007DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÊDW! AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDì¸HržT¸DW§DŒÜHs7\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDì¸HržT¸DWD¤Hr¹»DW’D… Hss€ DW§DŒÜHs7\Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071511100715111007.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÊDW! AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDì¸HržT¸DW§DŒÜHs7\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDì¸HržT¸DWD¤Hr¹»DW’D… Hss€ DW§DŒÜHs7\Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071511100715111007DW’DW’B£REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÊDW! AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDì¸HržT¸DW§DŒÜHs7\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDì¸HržT¸DWD¤Hr¹»DW’D… Hss€ DW§DŒÜHs7\Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071511100715111007.DWÊBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÊDW!YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDì¸HržT¸DW§DŒÜHs7\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDì¸HržT¸DWD¤Hr¹»DW’D… Hss€ DW§DŒÜHs7\Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071512100715121007DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDòXHržZXDWDëÈHrºHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDòXHržZXDWDëÈHrºH......Phase 3A@..DW!DW´12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSAC4591001C4591001 1007 10071512100715121007.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDòXHržZXDWDëÈHrºHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDòXHržZXDWDëÈHrºH......Phase 3A@..DW!DW´12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSA C4591001C4591001 1007 10071514100715141007DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW´.DW$ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDñ¤HržY¤DWDÎHr¹å„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDñ¤HržY¤DWDÎHr¹å„......Phase 3A@..DW$DW´12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071514100715141007.DW$B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW´.DW$ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDñ¤HržY¤DWDÎHr¹å„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDñ¤HržY¤DWDÎHr¹å„......Phase 3A@..DW$DW´12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071515100715151007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DW·.DW" AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDŠHHrŸCÈDWDèHrºøèPlacebo Placebo 12-15 YearsA . . .DVñDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVñDŠHHrŸCÈDWDèHrºøè......Phase 3A@..DW"DW·12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071515100715151007.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DW·.DW" AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDŠHHrŸCÈDWDèHrºøèPlacebo Placebo 12-15 YearsA . . .DVñDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVñDŠHHrŸCÈDWDèHrºøè......Phase 3A@..DW"DW·12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071516100715161007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÊDW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDˆ¤HrŸB$DW§D•LHs?ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDˆ¤HrŸB$DWD PHr» PDW’DÔ”HssÏ”DW§D•LHs?ÌPhase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071516100715161007.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÊDW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDˆ¤HrŸB$DW§D•LHs?ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDˆ¤HrŸB$DWD PHr» PDW’DÔ”HssÏ”DW§D•LHs?ÌPhase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071516100715161007DW’DW’B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÊDW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDˆ¤HrŸB$DW§D•LHs?ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDˆ¤HrŸB$DWD PHr» PDW’DÔ”HssÏ”DW§D•LHs?ÌPhase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071516100715161007.DWÊBÚOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÊDW"YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDˆ¤HrŸB$DW§D•LHs?ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDˆ¤HrŸB$DWD PHr» PDW’DÔ”HssÏ”DW§D•LHs?ÌPhase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071517100715171007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD—,HrŸP¬DWDßÔHr»HÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD—,HrŸP¬DWDßÔHr»HÔ......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071517100715171007.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD—,HrŸP¬DWDßÔHr»HÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD—,HrŸP¬DWDßÔHr»HÔ......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071518100715181007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¾.DW" AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDŸ`HrŸXàDWD‡xHrºðxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDŸ`HrŸXàDWD‡xHrºðx......Phase 3A@..DW"DW¾12-15 YearsA YNY. DW=DWýDWýAðYEARSDSAC4591001C4591001 1007 10071518100715181007.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¾.DW" AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDŸ`HrŸXàDWD‡xHrºðxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDŸ`HrŸXàDWD‡xHrºðx......Phase 3A@..DW"DW¾12-15 YearsA YNY. DW=DWýDWýAðYEARSDSA C4591001C4591001 1007 10071519100715191007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW“DW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD¨HHrŸaÈDWwDÇtHsP)ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWbDWw.DWaPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD¨HHrŸaÈDWD Hr» DWbD™HHs4LHDWwDÇtHsP)ôPhase 3A@..DW#.12-15 YearsA YNN. DW`DWýDWýAðYEARSDSAC4591001C4591001 1007 10071519100715191007.DW#B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW“DW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD¨HHrŸaÈDWwDÇtHsP)ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWbDWw.DWaPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD¨HHrŸaÈDWD Hr» DWbD™HHs4LHDWwDÇtHsP)ôPhase 3A@..DW#.12-15 YearsA YNN. DW`DWýDWýAðYEARSDSA C4591001C4591001 1007 10071519100715191007DWbDWbBrREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW“DW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD¨HHrŸaÈDWwDÇtHsP)ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWbDWw.DWaPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD¨HHrŸaÈDWD Hr» DWbD™HHs4LHDWwDÇtHsP)ôPhase 3A@..DW#.12-15 YearsA YNN. DW`DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071519100715191007.DW“B£OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW“DW#YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD¨HHrŸaÈDWwDÇtHsP)ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWbDWw.DWaPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD¨HHrŸaÈDWD Hr» DWbD™HHs4LHDWwDÇtHsP)ôPhase 3A@..DW#.12-15 YearsA YNN. DW`DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071520100715201007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÝDW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD©tHrŸbôDW¾DŒ(Hs‰(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¨DW¾.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD©tHrŸbôDWD¡|Hr» |DW¨D¿@Hs»@DW¾DŒ(Hs‰(Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071520100715201007.DW#B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÝDW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD©tHrŸbôDW¾DŒ(Hs‰(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¨DW¾.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD©tHrŸbôDWD¡|Hr» |DW¨D¿@Hs»@DW¾DŒ(Hs‰(Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071520100715201007DW¨DW¨B¸REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÝDW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD©tHrŸbôDW¾DŒ(Hs‰(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¨DW¾.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD©tHrŸbôDWD¡|Hr» |DW¨D¿@Hs»@DW¾DŒ(Hs‰(Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071520100715201007.DWÝBíOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÝDW#YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD©tHrŸbôDW¾DŒ(Hs‰(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¨DW¾.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD©tHrŸbôDWD¡|Hr» |DW¨D¿@Hs»@DW¾DŒ(Hs‰(Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071521100715211007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DWµ.DW$ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÂˆHrŸ|DWDÑLHr»:LBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÂˆHrŸ|DWDÑLHr»:L......Phase 3A@..DW$DWµ12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071521100715211007.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DWµ.DW$ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÂˆHrŸ|DWDÑLHr»:LBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÂˆHrŸ|DWDÑLHr»:L......Phase 3A@..DW$DWµ12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071522100715221007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÛØHrŸ•XDW¯DÓàHsš `Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDÛØHrŸ•XDWDÎ|Hr»7|DWšD¢0Hs~)0DW¯DÓàHsš `Phase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071522100715221007.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÛØHrŸ•XDW¯DÓàHsš `Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDÛØHrŸ•XDWDÎ|Hr»7|DWšD¢0Hs~)0DW¯DÓàHsš `Phase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071522100715221007DWšDWšBªREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÛØHrŸ•XDW¯DÓàHsš `Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDÛØHrŸ•XDWDÎ|Hr»7|DWšD¢0Hs~)0DW¯DÓàHsš `Phase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071522100715221007.DWÍBÝOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÛØHrŸ•XDW¯DÓàHsš `Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDÛØHrŸ•XDWDÎ|Hr»7|DWšD¢0Hs~)0DW¯DÓàHsš `Phase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071523100715231007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÙøHrŸ“xDWD¤Hr» BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÙøHrŸ“xDWD¤Hr» ......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071523100715231007.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÙøHrŸ“xDWD¤Hr» BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÙøHrŸ“xDWD¤Hr» ......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071524100715241007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWvDW* AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDíäHrŸ§dDWUDãHs#rœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW@DWU.DW1Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDíäHrŸ§dDWD Hr» DW@DÑLHs±LDWUDãHs#rœPhase 3A@..DW*.12-15 YearsA YNN. DW0DWýDWýAðYEARSDSAC4591001C4591001 1007 10071524100715241007.DW*B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWvDW* AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDíäHrŸ§dDWUDãHs#rœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW@DWU.DW1Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDíäHrŸ§dDWD Hr» DW@DÑLHs±LDWUDãHs#rœPhase 3A@..DW*.12-15 YearsA YNN. DW0DWýDWýAðYEARSDSA C4591001C4591001 1007 10071524100715241007DW@DW@BPREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWvDW* AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDíäHrŸ§dDWUDãHs#rœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW@DWU.DW1Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDíäHrŸ§dDWD Hr» DW@DÑLHs±LDWUDãHs#rœPhase 3A@..DW*.12-15 YearsA YNN. DW0DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071524100715241007.DWvB†OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWvDW*YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDíäHrŸ§dDWUDãHs#rœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW@DWU.DW1Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDíäHrŸ§dDWD Hr» DW@DÑLHs±LDWUDãHs#rœPhase 3A@..DW*.12-15 YearsA YNN. DW0DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071525100715251007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW·.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDì@HrŸ¥ÀDWD¡@Hr» @BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDì@HrŸ¥ÀDWD¡@Hr» @......Phase 3A@..DW*DW·12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071525100715251007.DW*B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW·.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDì@HrŸ¥ÀDWD¡@Hr» @BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDì@HrŸ¥ÀDWD¡@Hr» @......Phase 3A@..DW*DW·12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071526100715261007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDóHHrŸ¬ÈDWDÄhHr»-hBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDóHHrŸ¬ÈDWDÄhHr»-h......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071526100715261007.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDóHHrŸ¬ÈDWDÄhHr»-hBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDóHHrŸ¬ÈDWDÄhHr»-h......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071527100715271007DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÒDW" AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDñ,HrŸª¬DWµDÇ°Hs¡ç0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDñ,HrŸª¬DWDÅXHr».XDW¢D©ìHsˆ¼ìDWµDÇ°Hs¡ç0Phase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071527100715271007.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÒDW" AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDñ,HrŸª¬DWµDÇ°Hs¡ç0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDñ,HrŸª¬DWDÅXHr».XDW¢D©ìHsˆ¼ìDWµDÇ°Hs¡ç0Phase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071527100715271007DW¢DW¢B²REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÒDW" AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDñ,HrŸª¬DWµDÇ°Hs¡ç0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDñ,HrŸª¬DWDÅXHr».XDW¢D©ìHsˆ¼ìDWµDÇ°Hs¡ç0Phase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071527100715271007.DWÒBâOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÒDW"YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDñ,HrŸª¬DWµDÇ°Hs¡ç0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDñ,HrŸª¬DWDÅXHr».XDW¢D©ìHsˆ¼ìDWµDÇ°Hs¡ç0Phase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071528100715281007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD‡ðHr ’ðDWD¿@Hr¼yÀPlacebo Placebo 12-15 YearsA . . .DVòDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVòD‡ðHr ’ðDWD¿@Hr¼yÀ......Phase 3A@..DW#DW¶12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071528100715281007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD‡ðHr ’ðDWD¿@Hr¼yÀPlacebo Placebo 12-15 YearsA . . .DVòDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVòD‡ðHr ’ðDWD¿@Hr¼yÀ......Phase 3A@..DW#DW¶12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071529100715291007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¼.DW# AàYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD“0Hr ž0DWD‘ÈHr¼LHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD“0Hr ž0DWD‘ÈHr¼LH......Phase 3A@..DW#DW¼12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071529100715291007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¼.DW# AàYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD“0Hr ž0DWD‘ÈHr¼LHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD“0Hr ž0DWD‘ÈHr¼LH......Phase 3A@..DW#DW¼12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071530100715301007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµ.DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD–Hr ¡DWDçHr»PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD–Hr ¡DWDçHr»P......Phase 3A@..DW#DWµ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071530100715301007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµ.DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD–Hr ¡DWDçHr»PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD–Hr ¡DWDçHr»P......Phase 3A@..DW#DWµ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071531100715311007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÙDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD—hHr ¢hDWµD…\Hs¡¤ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW™DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD—hHr ¢hDWDêØHr»SØDW™DªdHs|ßäDWµD…\Hs¡¤ÜPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071531100715311007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÙDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD—hHr ¢hDWµD…\Hs¡¤ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW™DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD—hHr ¢hDWDêØHr»SØDW™DªdHs|ßäDWµD…\Hs¡¤ÜPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071531100715311007DW™DW™B¨REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÙDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD—hHr ¢hDWµD…\Hs¡¤ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW™DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD—hHr ¢hDWDêØHr»SØDW™DªdHs|ßäDWµD…\Hs¡¤ÜPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1007 10071531100715311007.DWÙBèOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÙDW#YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD—hHr ¢hDWµD…\Hs¡¤ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW™DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD—hHr ¢hDWDêØHr»SØDW™DªdHs|ßäDWµD…\Hs¡¤ÜPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1007 10071533100715331007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÐDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¥xHr °xDW¯D›dHs™ÑäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¥xHr °xDWD§ÐHr¼bPDWšD€Hs~$€DW¯D›dHs™ÑäPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071533100715331007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÐDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¥xHr °xDW¯D›dHs™ÑäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¥xHr °xDWD§ÐHr¼bPDWšD€Hs~$€DW¯D›dHs™ÑäPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071533100715331007DWšDWšB©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÐDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¥xHr °xDW¯D›dHs™ÑäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¥xHr °xDWD§ÐHr¼bPDWšD€Hs~$€DW¯D›dHs™ÑäPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071533100715331007.DWÐBßOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÐDW#YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¥xHr °xDW¯D›dHs™ÑäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¥xHr °xDWD§ÐHr¼bPDWšD€Hs~$€DW¯D›dHs™ÑäPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071535100715351007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW».DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD¨Hr ³DWD´<Hr¼n¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD¨Hr ³DWD´<Hr¼n¼......Phase 3A@..DW#DW»12-15 YearsA YNY. DW=DWýDWýAðYEARSDSAC4591001C4591001 1007 10071535100715351007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW».DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD¨Hr ³DWD´<Hr¼n¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD¨Hr ³DWD´<Hr¼n¼......Phase 3A@..DW#DW»12-15 YearsA YNY. DW=DWýDWýAðYEARSDSA C4591001C4591001 1007 10071536100715361007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DW°.DW" AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD´Hr ¿DWDß˜Hr»H˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD´Hr ¿DWDß˜Hr»H˜......Phase 3A@..DW"DW°12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071536100715361007.DW"B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DW°.DW" AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD´Hr ¿DWDß˜Hr»H˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD´Hr ¿DWDß˜Hr»H˜......Phase 3A@..DW"DW°12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071537100715371007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÇ°Hr Ò°DWDæÜHr¼¡\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÇ°Hr Ò°DWDæÜHr¼¡\......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071537100715371007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÇ°Hr Ò°DWDæÜHr¼¡\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÇ°Hr Ò°DWDæÜHr¼¡\......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071539100715391007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÒDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDØTHr ãTDW¶DË¬Hs£<¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDØTHr ãTDWDÊ€Hr¼…DW¡DË4Hs‡Œ´DW¶DË¬Hs£<¬Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071539100715391007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÒDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDØTHr ãTDW¶DË¬Hs£<¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDØTHr ãTDWDÊ€Hr¼…DW¡DË4Hs‡Œ´DW¶DË¬Hs£<¬Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071539100715391007DW¡DW¡B°REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÒDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDØTHr ãTDW¶DË¬Hs£<¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDØTHr ãTDWDÊ€Hr¼…DW¡DË4Hs‡Œ´DW¶DË¬Hs£<¬Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071539100715391007.DWÒBáOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÒDW#YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDØTHr ãTDW¶DË¬Hs£<¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDØTHr ãTDWDÊ€Hr¼…DW¡DË4Hs‡Œ´DW¶DË¬Hs£<¬Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071540100715401007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÓDW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÙøHr äøDW¶DÈ(Hs£9(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÙøHr äøDWDËpHr¼…ðDW¡DÌ$Hs‡¤DW¶DÈ(Hs£9(Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071540100715401007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÓDW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÙøHr äøDW¶DÈ(Hs£9(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÙøHr äøDWDËpHr¼…ðDW¡DÌ$Hs‡¤DW¶DÈ(Hs£9(Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071540100715401007DW¡DW¡B°REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÓDW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÙøHr äøDW¶DÈ(Hs£9(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÙøHr äøDWDËpHr¼…ðDW¡DÌ$Hs‡¤DW¶DÈ(Hs£9(Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071540100715401007.DWÓBâOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÓDW#YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÙøHr äøDW¶DÈ(Hs£9(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÙøHr äøDWDËpHr¼…ðDW¡DÌ$Hs‡¤DW¶DÈ(Hs£9(Phase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071541100715411007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWaDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDì¸Hr ÷¸DWEDÖ8HsM¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW0DWE.DW/Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDì¸Hr ÷¸DWDÓhHr¼èDW0DÛœHrò£œDWEDÖ8HsM¸Phase 3A@..DW$.12-15 YearsAYYNN. DW.DWýDWýAðYEARSDSAC4591001C4591001 1007 10071541100715411007.DW$B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWaDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDì¸Hr ÷¸DWEDÖ8HsM¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW0DWE.DW/Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDì¸Hr ÷¸DWDÓhHr¼èDW0DÛœHrò£œDWEDÖ8HsM¸Phase 3A@..DW$.12-15 YearsAYYNN. DW.DWýDWýAðYEARSDSA C4591001C4591001 1007 10071541100715411007DW0DW0B?REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWaDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDì¸Hr ÷¸DWEDÖ8HsM¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW0DWE.DW/Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDì¸Hr ÷¸DWDÓhHr¼èDW0DÛœHrò£œDWEDÖ8HsM¸Phase 3A@..DW$.12-15 YearsAYYNN. DW.DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071541100715411007.DWaBpOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWaDW$YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDì¸Hr ÷¸DWEDÖ8HsM¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW0DWE.DW/Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDì¸Hr ÷¸DWDÓhHr¼èDW0DÛœHrò£œDWEDÖ8HsM¸Phase 3A@..DW$.12-15 YearsAYYNN. DW.DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071542100715421007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¶.DW( AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDðHr ûDWDçHr¼¢BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDðHr ûDWDçHr¼¢......Phase 3A@..DW(DW¶12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071542100715421007.DW(B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¶.DW( AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDðHr ûDWDçHr¼¢BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDðHr ûDWDçHr¼¢......Phase 3A@..DW(DW¶12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071543100715431007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDð<Hr û<DWDÆHHr¼€ÈPlacebo Placebo 12-15 YearsA . . .DVòDW....DWPlacebo Placebo Placebo A .Placebo A .DVòDð<Hr û<DWDÆHHr¼€È......Phase 3A@..DW#DW¶12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071543100715431007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDð<Hr û<DWDÆHHr¼€ÈPlacebo Placebo 12-15 YearsA . . .DVòDW....DWPlacebo Placebo Placebo A .Placebo A .DVòDð<Hr û<DWDÆHHr¼€È......Phase 3A@..DW#DW¶12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071544100715441007DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¾.DW# AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDñ,Hr ü,DWDÇìHr¼‚lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDñ,Hr ü,DWDÇìHr¼‚l......Phase 3A@..DW#DW¾12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071544100715441007.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¾.DW# AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDñ,Hr ü,DWDÇìHr¼‚lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDñ,Hr ü,DWDÇìHr¼‚l......Phase 3A@..DW#DW¾12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071546100715461007DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD‹8Hr¡ç¸DWD–Hr¼P€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD‹8Hr¡ç¸DWD–Hr¼P€......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSAC4591001C4591001 1007 10071546100715461007.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD‹8Hr¡ç¸DWD–Hr¼P€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD‹8Hr¡ç¸DWD–Hr¼P€......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSA C4591001C4591001 1007 10071547100715471007DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÊDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDštHr¡öôDW©D› Hs‘é Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDštHr¡öôDWD¼Hr¼X<DW”DÄ¤Hsvb¤DW©D› Hs‘é Phase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071547100715471007.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÊDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDštHr¡öôDW©D› Hs‘é Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDštHr¡öôDWD¼Hr¼X<DW”DÄ¤Hsvb¤DW©D› Hs‘é Phase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071547100715471007DW”DW”B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÊDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDštHr¡öôDW©D› Hs‘é Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDštHr¡öôDWD¼Hr¼X<DW”DÄ¤Hsvb¤DW©D› Hs‘é Phase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1007 10071547100715471007.DWÊBØOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÊDW#YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDštHr¡öôDW©D› Hs‘é Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDštHr¡öôDWD¼Hr¼X<DW”DÄ¤Hsvb¤DW©D› Hs‘é Phase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1007 10071550100715501007DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW·.DW$ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD× Hr¢4 DWDÕüHr¼|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD× Hr¢4 DWDÕüHr¼|......Phase 3A@..DW$DW·12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071550100715501007.DW$B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW·.DW$ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD× Hr¢4 DWDÕüHr¼|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD× Hr¢4 DWDÕüHr¼|......Phase 3A@..DW$DW·12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071551100715511007DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÉDW$ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÔÐHr¢1PDWDÐ\Hs—cÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÔÐHr¢1PDWDÆÀHr»/ÀDW˜DÂÄHs{¦ÄDWDÐ\Hs—cÜPhase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071551100715511007.DW$B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÉDW$ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÔÐHr¢1PDWDÐ\Hs—cÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÔÐHr¢1PDWDÆÀHr»/ÀDW˜DÂÄHs{¦ÄDWDÐ\Hs—cÜPhase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071551100715511007DW˜DW˜B¦REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÉDW$ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÔÐHr¢1PDWDÐ\Hs—cÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÔÐHr¢1PDWDÆÀHr»/ÀDW˜DÂÄHs{¦ÄDWDÐ\Hs—cÜPhase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071551100715511007.DWÉB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÉDW$YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÔÐHr¢1PDWDÐ\Hs—cÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÔÐHr¢1PDWDÆÀHr»/ÀDW˜DÂÄHs{¦ÄDWDÐ\Hs—cÜPhase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071552100715521007DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÍDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDê`Hr¢FàDW¯DÑˆHsšPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDê`Hr¢FàDWDÆ„Hr»/„DWšDÏlHs~VlDW¯DÑˆHsšPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071552100715521007.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÍDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDê`Hr¢FàDW¯DÑˆHsšPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDê`Hr¢FàDWDÆ„Hr»/„DWšDÏlHs~VlDW¯DÑˆHsšPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071552100715521007DWšDWšB¨REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÍDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDê`Hr¢FàDW¯DÑˆHsšPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDê`Hr¢FàDWDÆ„Hr»/„DWšDÏlHs~VlDW¯DÑˆHsšPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071552100715521007.DWÍBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÍDW#YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDê`Hr¢FàDW¯DÑˆHsšPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDê`Hr¢FàDWDÆ„Hr»/„DWšDÏlHs~VlDW¯DÑˆHsšPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071554100715541007DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW·.DW$ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDíäHr¢JdDWDÙ¼Hr¼”<Placebo Placebo 12-15 YearsA . . .DVóDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVóDíäHr¢JdDWDÙ¼Hr¼”<......Phase 3A@..DW$DW·12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071554100715541007.DW$B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW·.DW$ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDíäHr¢JdDWDÙ¼Hr¼”<Placebo Placebo 12-15 YearsA . . .DVóDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVóDíäHr¢JdDWDÙ¼Hr¼”<......Phase 3A@..DW$DW·12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071555100715551007DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDépHr¢EðDWDÞ0Hr»G0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDépHr¢EðDWDÞ0Hr»G0......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071555100715551007.DW"B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDépHr¢EðDWDÞ0Hr»G0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDépHr¢EðDWDÞ0Hr»G0......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071557100715571007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÓ.DW+ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DˆhHr§*èDWDœHrÂîBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DˆhHr§*èDWDœHrÂî......Phase 3A@..DW+DWÓ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071557100715571007.DW+B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÓ.DW+ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DˆhHr§*èDWDœHrÂîBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DˆhHr§*èDWDœHrÂî......Phase 3A@..DW+DWÓ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071558100715581007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW».DW* AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DŠüHr§-|DWD†LHrÂØLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DŠüHr§-|DWD†LHrÂØL......Phase 3A@..DW*DW»12-15 YearsAYYNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1007 10071558100715581007.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW».DW* AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DŠüHr§-|DWD†LHrÂØLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DŠüHr§-|DWD†LHrÂØL......Phase 3A@..DW*DW»12-15 YearsAYYNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1007 10071559100715591007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÍDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D¦àHr§I`DW°D¥ðHs›-ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW›DW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D¦àHr§I`DWDÜŒHrÃ.ŒDW›DÞ0Hs¶°DW°D¥ðHs›-ðPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071559100715591007.DW/B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÍDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D¦àHr§I`DW°D¥ðHs›-ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW›DW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D¦àHr§I`DWDÜŒHrÃ.ŒDW›DÞ0Hs¶°DW°D¥ðHs›-ðPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071559100715591007DW›DW›B¥REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÍDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D¦àHr§I`DW°D¥ðHs›-ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW›DW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D¦àHr§I`DWDÜŒHrÃ.ŒDW›DÞ0Hs¶°DW°D¥ðHs›-ðPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1007 10071559100715591007.DWÍB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÍDW/YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D¦àHr§I`DW°D¥ðHs›-ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW›DW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D¦àHr§I`DWDÜŒHrÃ.ŒDW›DÞ0Hs¶°DW°D¥ðHs›-ðPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1007 10071560100715601007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÉÌHr§lLDW¦DÒHsŽ+Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÉÌHr§lLDW DŠHHrÄ-ÈDW‘D´<Hsr]¼DW¦DÒHsŽ+Phase 3A@..DW).12-15 YearsAYYNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071560100715601007.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÉÌHr§lLDW¦DÒHsŽ+Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÉÌHr§lLDW DŠHHrÄ-ÈDW‘D´<Hsr]¼DW¦DÒHsŽ+Phase 3A@..DW).12-15 YearsAYYNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071560100715601007DW‘DW‘B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÉÌHr§lLDW¦DÒHsŽ+Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÉÌHr§lLDW DŠHHrÄ-ÈDW‘D´<Hsr]¼DW¦DÒHsŽ+Phase 3A@..DW).12-15 YearsAYYNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071560100715601007.DWÃBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW)YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÉÌHr§lLDW¦DÒHsŽ+Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÉÌHr§lLDW DŠHHrÄ-ÈDW‘D´<Hsr]¼DW¦DÒHsŽ+Phase 3A@..DW).12-15 YearsAYYNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071561100715611007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW».DW) AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÔÐHr§wPDWDÓàHrÃ%àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÔÐHr§wPDWDÓàHrÃ%à......Phase 3A@..DW)DW»12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071561100715611007.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW».DW) AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÔÐHr§wPDWDÓàHrÃ%àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÔÐHr§wPDWDÓàHrÃ%à......Phase 3A@..DW)DW»12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071562100715621007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW( AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DèHr§ŠˆDW¦D®ØHsŽØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DèHr§ŠˆDWDð<HrÃB<DW‘D HsrI”DW¦D®ØHsŽØPhase 3A@..DW(.12-15 YearsAYYNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071562100715621007.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW( AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DèHr§ŠˆDW¦D®ØHsŽØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DèHr§ŠˆDWDð<HrÃB<DW‘D HsrI”DW¦D®ØHsŽØPhase 3A@..DW(.12-15 YearsAYYNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071562100715621007DW‘DW‘B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW( AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DèHr§ŠˆDW¦D®ØHsŽØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DèHr§ŠˆDWDð<HrÃB<DW‘D HsrI”DW¦D®ØHsŽØPhase 3A@..DW(.12-15 YearsAYYNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071562100715621007.DWÃBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW(YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DèHr§ŠˆDW¦D®ØHsŽØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DèHr§ŠˆDWDð<HrÃB<DW‘D HsrI”DW¦D®ØHsŽØPhase 3A@..DW(.12-15 YearsAYYNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071563100715631007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW( AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DåìHr§ˆlDW¦D°HsŽ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DåìHr§ˆlDWDî˜HrÃ@˜DW‘D¡HsrJ„DW¦D°HsŽ Phase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071563100715631007.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW( AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DåìHr§ˆlDW¦D°HsŽ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DåìHr§ˆlDWDî˜HrÃ@˜DW‘D¡HsrJ„DW¦D°HsŽ Phase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071563100715631007DW‘DW‘B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW( AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DåìHr§ˆlDW¦D°HsŽ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DåìHr§ˆlDWDî˜HrÃ@˜DW‘D¡HsrJ„DW¦D°HsŽ Phase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071563100715631007.DWÃBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW(YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DåìHr§ˆlDW¦D°HsŽ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DåìHr§ˆlDWDî˜HrÃ@˜DW‘D¡HsrJ„DW¦D°HsŽ Phase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071564100715641007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DW½.DW/ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DñhHr§“èDWDÛØHrÅÐØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DñhHr§“èDWDÛØHrÅÐØ......Phase 3A@..DW/DW½12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071564100715641007.DW/B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DW½.DW/ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DñhHr§“èDWDÛØHrÅÐØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DñhHr§“èDWDÛØHrÅÐØ......Phase 3A@..DW/DW½12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071565100715651007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DW½.DW/ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dô8Hr§–¸DWDÝ@HrÅÒ@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dô8Hr§–¸DWDÝ@HrÅÒ@......Phase 3A@..DW/DW½12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071565100715651007.DW/B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DW½.DW/ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dô8Hr§–¸DWDÝ@HrÅÒ@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dô8Hr§–¸DWDÝ@HrÅÒ@......Phase 3A@..DW/DW½12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071566100715661007DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÄ.DW( AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DòXHr§”ØDWDé4HrÃ;4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DòXHr§”ØDWDé4HrÃ;4......Phase 3A@..DW(DWÄ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1007 10071566100715661007.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÄ.DW( AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DòXHr§”ØDWDé4HrÃ;4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DòXHr§”ØDWDé4HrÃ;4......Phase 3A@..DW(DWÄ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1007 10071567100715671007DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDŽHr¨‚DW DØHrÄ%XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDŽHr¨‚DW DØHrÄ%X......Phase 3A@..DW)DW¼12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071567100715671007.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDŽHr¨‚DW DØHrÄ%XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDŽHr¨‚DW DØHrÄ%X......Phase 3A@..DW)DW¼12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071568100715681007DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÓDW) AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD`Hr¨„`DWµD…\Hs¡¤ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD`Hr¨„`DW DâàHrÄ†`DW DHs…ýDWµD…\Hs¡¤ÜPhase 3A@..DW).12-15 YearsA YNN. DW’DWýDWýAàYEARSDSAC4591001C4591001 1007 10071568100715681007.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÓDW) AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD`Hr¨„`DWµD…\Hs¡¤ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD`Hr¨„`DW DâàHrÄ†`DW DHs…ýDWµD…\Hs¡¤ÜPhase 3A@..DW).12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA C4591001C4591001 1007 10071568100715681007DW DW B©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÓDW) AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD`Hr¨„`DWµD…\Hs¡¤ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD`Hr¨„`DW DâàHrÄ†`DW DHs…ýDWµD…\Hs¡¤ÜPhase 3A@..DW).12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071568100715681007.DWÓBÜOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÓDW)YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD`Hr¨„`DWµD…\Hs¡¤ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD`Hr¨„`DW DâàHrÄ†`DW DHs…ýDWµD…\Hs¡¤ÜPhase 3A@..DW).12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071569100715691007DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÓDW* AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDHr¨‘DW¶D‘ŒHs£ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW¢DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDHr¨‘DW DÃ<HrÄf¼DW¢D§XHsˆºXDW¶D‘ŒHs£ŒPhase 3A@..DW*.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071569100715691007.DW*B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÓDW* AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDHr¨‘DW¶D‘ŒHs£ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW¢DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDHr¨‘DW DÃ<HrÄf¼DW¢D§XHsˆºXDW¶D‘ŒHs£ŒPhase 3A@..DW*.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071569100715691007DW¢DW¢B«REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÓDW* AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDHr¨‘DW¶D‘ŒHs£ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW¢DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDHr¨‘DW DÃ<HrÄf¼DW¢D§XHsˆºXDW¶D‘ŒHs£ŒPhase 3A@..DW*.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071569100715691007.DWÓBÜOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÓDW*YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDHr¨‘DW¶D‘ŒHs£ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW¢DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDHr¨‘DW DÃ<HrÄf¼DW¢D§XHsˆºXDW¶D‘ŒHs£ŒPhase 3A@..DW*.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071570100715701007DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÓDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD PHr¨”PDW¶D“0Hs£0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW¢DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD PHr¨”PDW DÂLHrÄeÌDW¢D¨„Hsˆ»„DW¶D“0Hs£0Phase 3A@..DW*.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071570100715701007.DW*B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÓDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD PHr¨”PDW¶D“0Hs£0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW¢DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD PHr¨”PDW DÂLHrÄeÌDW¢D¨„Hsˆ»„DW¶D“0Hs£0Phase 3A@..DW*.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071570100715701007DW¢DW¢B«REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÓDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD PHr¨”PDW¶D“0Hs£0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW¢DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD PHr¨”PDW DÂLHrÄeÌDW¢D¨„Hsˆ»„DW¶D“0Hs£0Phase 3A@..DW*.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071570100715701007.DWÓBÜOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÓDW*YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD PHr¨”PDW¶D“0Hs£0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW¢DW¶.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD PHr¨”PDW DÂLHrÄeÌDW¢D¨„Hsˆ»„DW¶D“0Hs£0Phase 3A@..DW*.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071571100715711007DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÁ˜Hr¨µ˜DWDè€HrÅÝ€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÁ˜Hr¨µ˜DWDè€HrÅÝ€......Phase 3A@..DW*DW½12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071571100715711007.DW*B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÁ˜Hr¨µ˜DWDè€HrÅÝ€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÁ˜Hr¨µ˜DWDè€HrÅÝ€......Phase 3A@..DW*DW½12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071572100715721007DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÃ.DW) AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDð<Hr¨ä<DW Dá´HrÄ…4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDð<Hr¨ä<DW Dá´HrÄ…4......Phase 3A@..DW)DWÃ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071572100715721007.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÃ.DW) AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDð<Hr¨ä<DW Dá´HrÄ…4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDð<Hr¨ä<DW Dá´HrÄ…4......Phase 3A@..DW)DWÃ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071573100715731007DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDòXHr¨æXDWDÕüHrÃ'üPlacebo Placebo 12-15 YearsA . . .DVøDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVøDòXHr¨æXDWDÕüHrÃ'ü......Phase 3A@..DW*DW½12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071573100715731007.DW*B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDòXHr¨æXDWDÕüHrÃ'üPlacebo Placebo 12-15 YearsA . . .DVøDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVøDòXHr¨æXDWDÕüHrÃ'ü......Phase 3A@..DW*DW½12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071574100715741007DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÃ.DW+ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDŒ Hr©Ò DWD½ØHrÅ²ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDŒ Hr©Ò DWD½ØHrÅ²Ø......Phase 3A@..DW+DWÃ12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSAC4591001C4591001 1007 10071574100715741007.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÃ.DW+ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDŒ Hr©Ò DWD½ØHrÅ²ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDŒ Hr©Ò DWD½ØHrÅ²Ø......Phase 3A@..DW+DWÃ12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSA C4591001C4591001 1007 10071575100715751007DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÕ„HrªDWDÒHrÅÇBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÕ„HrªDWDÒHrÅÇ......Phase 3A@..DW*DW½12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSAC4591001C4591001 1007 10071575100715751007.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÕ„HrªDWDÒHrÅÇBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÕ„HrªDWDÒHrÅÇ......Phase 3A@..DW*DW½12-15 YearsAYYNY. DW=DWýDWýAðYEARSDSA C4591001C4591001 1007 10071576100715761007DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DW¾DW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÚ4Hrª´DW¢DçHsˆúPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŒDW¢.DW}Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÚ4Hrª´DWDÞ¨HrÅÓ¨DWŒDïˆHslˆDW¢DçHsˆúPhase 3A@..DW*.12-15 YearsA YNN. DW|DWýDWýAðYEARSDSAC4591001C4591001 1007 10071576100715761007.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DW¾DW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÚ4Hrª´DW¢DçHsˆúPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŒDW¢.DW}Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÚ4Hrª´DWDÞ¨HrÅÓ¨DWŒDïˆHslˆDW¢DçHsˆúPhase 3A@..DW*.12-15 YearsA YNN. DW|DWýDWýAðYEARSDSA C4591001C4591001 1007 10071576100715761007DWŒDWŒB”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DW¾DW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÚ4Hrª´DW¢DçHsˆúPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŒDW¢.DW}Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÚ4Hrª´DWDÞ¨HrÅÓ¨DWŒDïˆHslˆDW¢DçHsˆúPhase 3A@..DW*.12-15 YearsA YNN. DW|DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071576100715761007.DW¾BÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DW¾DW*YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÚ4Hrª´DW¢DçHsˆúPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŒDW¢.DW}Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÚ4Hrª´DWDÞ¨HrÅÓ¨DWŒDïˆHslˆDW¢DçHsˆúPhase 3A@..DW*.12-15 YearsA YNN. DW|DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071577100715771007DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW§DW+ AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVùDöHrª<DW‹DŽ¼HsjO<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWuDW‹.DWpPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDöHrª<DWDÞäHrÅÓäDWuD‘HsMP”DW‹DŽ¼HsjO<Phase 3A@..DW+.12-15 YearsA YNN. DWoDWýDWýAðYEARSDSAC4591001C4591001 1007 10071577100715771007.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW§DW+ AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVùDöHrª<DW‹DŽ¼HsjO<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWuDW‹.DWpPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDöHrª<DWDÞäHrÅÓäDWuD‘HsMP”DW‹DŽ¼HsjO<Phase 3A@..DW+.12-15 YearsA YNN. DWoDWýDWýAðYEARSDSA C4591001C4591001 1007 10071577100715771007DWuDWuB}REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW§DW+ AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVùDöHrª<DW‹DŽ¼HsjO<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWuDW‹.DWpPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDöHrª<DWDÞäHrÅÓäDWuD‘HsMP”DW‹DŽ¼HsjO<Phase 3A@..DW+.12-15 YearsA YNN. DWoDWýDWýAðYEARSDSA0C4591001C4591001 1007 10071577100715771007.DW§B¯OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW§DW+YAðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVùDöHrª<DW‹DŽ¼HsjO<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWuDW‹.DWpPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDöHrª<DWDÞäHrÅÓäDWuD‘HsMP”DW‹DŽ¼HsjO<Phase 3A@..DW+.12-15 YearsA YNN. DWoDWýDWýAðYEARSDSA@C4591001C4591001 1007 10071578100715781007DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÉDW+ AÀYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVùDõ(Hrª:¨DWDÃðHs—WpPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDõ(Hrª:¨DWDàLHrÅÕLDW˜D¿¸Hs{£¸DWDÃðHs—WpPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071578100715781007.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÉDW+ AÀYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVùDõ(Hrª:¨DWDÃðHs—WpPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDõ(Hrª:¨DWDàLHrÅÕLDW˜D¿¸Hs{£¸DWDÃðHs—WpPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071578100715781007DW˜DW˜B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÉDW+ AÀYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVùDõ(Hrª:¨DWDÃðHs—WpPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDõ(Hrª:¨DWDàLHrÅÕLDW˜D¿¸Hs{£¸DWDÃðHs—WpPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071578100715781007.DWÉBÑOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÉDW+YAÀYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVùDõ(Hrª:¨DWDÃðHs—WpPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDõ(Hrª:¨DWDàLHrÅÕLDW˜D¿¸Hs{£¸DWDÃðHs—WpPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071579100715791007DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÄ.DW/ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD÷€Hrª=DWDÒHrÅÇBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD÷€Hrª=DWDÒHrÅÇ......Phase 3A@..DW/DWÄ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071579100715791007.DW/B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÄ.DW/ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD÷€Hrª=DWDÒHrÅÇBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD÷€Hrª=DWDÒHrÅÇ......Phase 3A@..DW/DWÄ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071580100715801007DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW½.DW+ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDù`Hrª>àDWDëŒHrÅàŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDù`Hrª>àDWDëŒHrÅàŒ......Phase 3A@..DW+DW½12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071580100715801007.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW½.DW+ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDù`Hrª>àDWDëŒHrÅàŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDù`Hrª>àDWDëŒHrÅàŒ......Phase 3A@..DW+DW½12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071581100715811007DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÊDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÞlHr«ulDWD Hs—3”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÞlHr«ulDWDÞlHrÇ$ìDW˜DªdHs{ŽdDWD Hs—3”Phase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071581100715811007.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÊDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÞlHr«ulDWD Hs—3”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÞlHr«ulDWDÞlHrÇ$ìDW˜DªdHs{ŽdDWD Hs—3”Phase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071581100715811007DW˜DW˜BŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÊDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÞlHr«ulDWD Hs—3”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÞlHr«ulDWDÞlHrÇ$ìDW˜DªdHs{ŽdDWD Hs—3”Phase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071581100715811007.DWÊBÑOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÊDW+YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÞlHr«ulDWD Hs—3”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÞlHr«ulDWDÞlHrÇ$ìDW˜DªdHs{ŽdDWD Hs—3”Phase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071582100715821007DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÅ.DW+ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDàÄHr«wÄDWDÝHrÇ#„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDàÄHr«wÄDWDÝHrÇ#„......Phase 3A@..DW+DWÅ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071582100715821007.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÅ.DW+ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDàÄHr«wÄDWDÝHrÇ#„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDàÄHr«wÄDWDÝHrÇ#„......Phase 3A@..DW+DWÅ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071583100715831007DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDêœHr«œDW¨DÃxHs¿xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDêœHr«œDWDàLHrÇ&ÌDW’D×(HssÒ(DW¨DÃxHs¿xPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071583100715831007.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDêœHr«œDW¨DÃxHs¿xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDêœHr«œDWDàLHrÇ&ÌDW’D×(HssÒ(DW¨DÃxHs¿xPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071583100715831007DW’DW’B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDêœHr«œDW¨DÃxHs¿xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDêœHr«œDWDàLHrÇ&ÌDW’D×(HssÒ(DW¨DÃxHs¿xPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071583100715831007.DWÆBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDêœHr«œDW¨DÃxHs¿xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW’DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDêœHr«œDWDàLHrÇ&ÌDW’D×(HssÒ(DW¨DÃxHs¿xPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071584100715841007DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDæÜHr«}ÜDWDãÐHrÇ*PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDæÜHr«}ÜDWDãÐHrÇ*P......Phase 3A@..DW+DW¾12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1007 10071584100715841007.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDæÜHr«}ÜDWDãÐHrÇ*PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDæÜHr«}ÜDWDãÐHrÇ*P......Phase 3A@..DW+DW¾12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1007 10071585100715851007DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDçTHr«~TDW§DÂHslPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDçTHr«~TDWDàˆHrÇ'DW‘DÕÀHsr@DW§DÂHslPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071585100715851007.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDçTHr«~TDW§DÂHslPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDçTHr«~TDWDàˆHrÇ'DW‘DÕÀHsr@DW§DÂHslPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071585100715851007DW‘DW‘B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDçTHr«~TDW§DÂHslPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDçTHr«~TDWDàˆHrÇ'DW‘DÕÀHsr@DW§DÂHslPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071585100715851007.DWÃBÊOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDçTHr«~TDW§DÂHslPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDçTHr«~TDWDàˆHrÇ'DW‘DÕÀHsr@DW§DÂHslPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071586100715861007DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÒDW+ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDèøHr«øDWµDŠHs¡©ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDèøHr«øDWDÞ0HrÇ$°DW DŽHs…þDWµDŠHs¡©ŒPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071586100715861007.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÒDW+ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDèøHr«øDWµDŠHs¡©ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDèøHr«øDWDÞ0HrÇ$°DW DŽHs…þDWµDŠHs¡©ŒPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071586100715861007DW DW B§REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÒDW+ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDèøHr«øDWµDŠHs¡©ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDèøHr«øDWDÞ0HrÇ$°DW DŽHs…þDWµDŠHs¡©ŒPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071586100715861007.DWÒBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÒDW+YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDèøHr«øDWµDŠHs¡©ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDèøHr«øDWDÞ0HrÇ$°DW DŽHs…þDWµDŠHs¡©ŒPhase 3A@..DW+.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071587100715871007DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDìHr«ƒDWDäÀHrÇ+@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDìHr«ƒDWDäÀHrÇ+@......Phase 3A@..DW+DW¾12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071587100715871007.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDìHr«ƒDWDäÀHrÇ+@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDìHr«ƒDWDäÀHrÇ+@......Phase 3A@..DW+DW¾12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071588100715881007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‘Hr¹¨”DWDƒ@Hr×í@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‘Hr¹¨”DWDƒ@Hr×í@......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071588100715881007.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‘Hr¹¨”DWDƒ@Hr×í@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‘Hr¹¨”DWDƒ@Hr×í@......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071589100715891007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÄDW8 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD ŒHr¹¸DW¨DÇ°HsÃ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD ŒHr¹¸DWDŠHHrÖ¢ÈDW’DÎHssÉDW¨DÇ°HsÃ°Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071589100715891007.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÄDW8 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD ŒHr¹¸DW¨DÇ°HsÃ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD ŒHr¹¸DWDŠHHrÖ¢ÈDW’DÎHssÉDW¨DÇ°HsÃ°Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071589100715891007DW’DW’BŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÄDW8 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD ŒHr¹¸DW¨DÇ°HsÃ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD ŒHr¹¸DWDŠHHrÖ¢ÈDW’DÎHssÉDW¨DÇ°HsÃ°Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071589100715891007.DWÄBÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÄDW8YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD ŒHr¹¸DW¨DÇ°HsÃ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD ŒHr¹¸DWDŠHHrÖ¢ÈDW’DÎHssÉDW¨DÇ°HsÃ°Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071590100715901007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¬Hr¹Å,DWDÞlHrØHlBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¬Hr¹Å,DWDÞlHrØHl......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071590100715901007.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¬Hr¹Å,DWDÞlHrØHlBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¬Hr¹Å,DWDÞlHrØHl......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071591100715911007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÓDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDµàHr¹Í`DW¶DƒôHs¢ôôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW¡DW¶.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDµàHr¹Í`DWD‚ÈHrÖ›HDW¡D ŒHs‡bDW¶DƒôHs¢ôôPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1007 10071591100715911007.DW>B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÓDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDµàHr¹Í`DW¶DƒôHs¢ôôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW¡DW¶.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDµàHr¹Í`DWD‚ÈHrÖ›HDW¡D ŒHs‡bDW¶DƒôHs¢ôôPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1007 10071591100715911007DW¡DW¡BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÓDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDµàHr¹Í`DW¶DƒôHs¢ôôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW¡DW¶.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDµàHr¹Í`DWD‚ÈHrÖ›HDW¡D ŒHs‡bDW¶DƒôHs¢ôôPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071591100715911007.DWÓBÏOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÓDW>YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDµàHr¹Í`DW¶DƒôHs¢ôôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW¡DW¶.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDµàHr¹Í`DWD‚ÈHrÖ›HDW¡D ŒHs‡bDW¶DƒôHs¢ôôPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071592100715921007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÊ.DW? AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD´xHr¹ËøDWD…\HrÖÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD´xHr¹ËøDWD…\HrÖÜ......Phase 3A@..DW?DWÊ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071592100715921007.DW?B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÊ.DW? AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD´xHr¹ËøDWD…\HrÖÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD´xHr¹ËøDWD…\HrÖÜ......Phase 3A@..DW?DWÊ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071593100715931007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED ...DWY AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¶Hr¹ÍœDWD¶Hr¹ÍœPlacebo Placebo 12-15 YearsA . . .DW.....DW3Placebo Placebo A .Placebo A .DWD¶Hr¹ÍœDWD¶Hr¹Íœ......Phase 3A@DW3DW..12-15 YearsA YNN. DW2DW3DW3AðYEARSDSAC4591001C4591001 1007 10071593100715931007.DWBVACCINATION BDISPOSITION EVENTPROTOCOL DEVIATION A°receipt of non-study COVID vaccine prior to study end ...DWY AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¶Hr¹ÍœDWD¶Hr¹ÍœPlacebo Placebo 12-15 YearsA . . .DW.....DW3Placebo Placebo A .Placebo A .DWD¶Hr¹ÍœDWD¶Hr¹Íœ......Phase 3A@DW3DW..12-15 YearsA YNN. DW2DW3DW3AðYEARSDSA0C4591001C4591001 1007 10071593100715931007.DW3B/FOLLOW-UP BDISPOSITION EVENTPROTOCOL DEVIATION A°Receipt of non-study COVID vaccine prior to study end ...DWY AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¶Hr¹ÍœDWD¶Hr¹ÍœPlacebo Placebo 12-15 YearsA . . .DW.....DW3Placebo Placebo A .Placebo A .DWD¶Hr¹ÍœDWD¶Hr¹Íœ......Phase 3A@DW3DW..12-15 YearsA YNN. DW2DW3DW3AðYEARSDSA@C4591001C4591001 1007 10071594100715941007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÉÌHr¹áLDWDíäHr×dBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÉÌHr¹áLDWDíäHr×d......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071594100715941007.DW=B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÉÌHr¹áLDWDíäHr×dBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÉÌHr¹áLDWDíäHr×d......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071595100715951007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÅDW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐ˜Hr¹èDW©D™üHs‘ç|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐ˜Hr¹èDWD˜ÐHrÖ±PDW’DŸ$Hssš$DW©D™üHs‘ç|Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071595100715951007.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÅDW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐ˜Hr¹èDW©D™üHs‘ç|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐ˜Hr¹èDWD˜ÐHrÖ±PDW’DŸ$Hssš$DW©D™üHs‘ç|Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071595100715951007DW’DW’BŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÅDW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐ˜Hr¹èDW©D™üHs‘ç|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐ˜Hr¹èDWD˜ÐHrÖ±PDW’DŸ$Hssš$DW©D™üHs‘ç|Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071595100715951007.DWÅBÁOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÅDW8YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐ˜Hr¹èDW©D™üHs‘ç|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐ˜Hr¹èDWD˜ÐHrÖ±PDW’DŸ$Hssš$DW©D™üHs‘ç|Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071596100715961007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÉDW8 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙHr¹ðˆDWD¡ôHs—5tPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙHr¹ðˆDWDÚpHrØDpDW˜DÐÔHs{´ÔDWD¡ôHs—5tPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071596100715961007.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÉDW8 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙHr¹ðˆDWD¡ôHs—5tPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙHr¹ðˆDWDÚpHrØDpDW˜DÐÔHs{´ÔDWD¡ôHs—5tPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071596100715961007DW˜DW˜B”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÉDW8 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙHr¹ðˆDWD¡ôHs—5tPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙHr¹ðˆDWDÚpHrØDpDW˜DÐÔHs{´ÔDWD¡ôHs—5tPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071596100715961007.DWÉBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÉDW8YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙHr¹ðˆDWD¡ôHs—5tPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙHr¹ðˆDWDÚpHrØDpDW˜DÐÔHs{´ÔDWD¡ôHs—5tPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071597100715971007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÌ.DW> AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÛ$Hr¹ò¤DWDãXHrÖûØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÛ$Hr¹ò¤DWDãXHrÖûØ......Phase 3A@..DW>DWÌ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071597100715971007.DW>B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÌ.DW> AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÛ$Hr¹ò¤DWDãXHrÖûØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÛ$Hr¹ò¤DWDãXHrÖûØ......Phase 3A@..DW>DWÌ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071599100715991007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÊ.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDê`HrºàDWDª(HrÖÂ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDê`HrºàDWDª(HrÖÂ¨......Phase 3A@..DW8DWÊ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071599100715991007.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÊ.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDê`HrºàDWDª(HrÖÂ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDê`HrºàDWDª(HrÖÂ¨......Phase 3A@..DW8DWÊ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071600100716001007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWèDW8 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDëPHrºÐDWËD¢¨Hs¾Ã(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWË.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëPHrºÐDWD©8HrÖÁ¸DW D¢lHs†lDWËD¢¨Hs¾Ã(Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071600100716001007.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWèDW8 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDëPHrºÐDWËD¢¨Hs¾Ã(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWË.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëPHrºÐDWD©8HrÖÁ¸DW D¢lHs†lDWËD¢¨Hs¾Ã(Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071600100716001007DW DW BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWèDW8 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDëPHrºÐDWËD¢¨Hs¾Ã(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWË.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëPHrºÐDWD©8HrÖÁ¸DW D¢lHs†lDWËD¢¨Hs¾Ã(Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071600100716001007.DWèBäOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWèDW8YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDëPHrºÐDWËD¢¨Hs¾Ã(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWË.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëPHrºÐDWD©8HrÖÁ¸DW D¢lHs†lDWËD¢¨Hs¾Ã(Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071601100716011007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWSDWÚ.DWS AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDí¨Hrº(DWDÚ4HrÖò´Placebo Placebo 12-15 YearsA . . .DWDW....DWŒPlacebo Placebo Placebo A .Placebo A .DWDí¨Hrº(DWDÚ4HrÖò´......Phase 3A@..DWSDWÚ12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071601100716011007.DWSBOVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWSDWÚ.DWS AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDí¨Hrº(DWDÚ4HrÖò´Placebo Placebo 12-15 YearsA . . .DWDW....DWŒPlacebo Placebo Placebo A .Placebo A .DWDí¨Hrº(DWDÚ4HrÖò´......Phase 3A@..DWSDWÚ12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071602100716021007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÑ.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDïˆHrºDWDî Hr× BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDïˆHrºDWDî Hr× ......Phase 3A@..DW8DWÑ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071602100716021007.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÑ.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDïˆHrºDWDî Hr× BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDïˆHrºDWDî Hr× ......Phase 3A@..DW8DWÑ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071603100716031007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽ€Hrº÷€DWDëŒHr×Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWDŽ€Hrº÷€DWDëŒHr×......Phase 3A@..DW>DWÑ12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1007 10071603100716031007.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽ€Hrº÷€DWDëŒHr×Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWDŽ€Hrº÷€DWDëŒHr×......Phase 3A@..DW>DWÑ12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1007 10071604100716041007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHrºððDWDé¬Hr×,Placebo Placebo 12-15 YearsA . . .DWDW....DWŒPlacebo Placebo Placebo A .Placebo A .DWD‡ðHrºððDWDé¬Hr×,......Phase 3A@..DW8DWË12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071604100716041007.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHrºððDWDé¬Hr×,Placebo Placebo 12-15 YearsA . . .DWDW....DWŒPlacebo Placebo Placebo A .Placebo A .DWD‡ðHrºððDWDé¬Hr×,......Phase 3A@..DW8DWË12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071605100716051007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÊ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD”\Hrºý\DWDŒÜHrÖ¥\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD”\Hrºý\DWDŒÜHrÖ¥\......Phase 3A@..DW>DWÊ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071605100716051007.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÊ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD”\Hrºý\DWDŒÜHrÖ¥\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD”\Hrºý\DWDŒÜHrÖ¥\......Phase 3A@..DW>DWÊ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071606100716061007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWGDWÐ.DWG AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¬DHr»DDWDépHr×ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¬DHr»DDWDépHr×ð......Phase 3A@..DWGDWÐ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1007 10071606100716061007.DWGBBVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWGDWÐ.DWG AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¬DHr»DDWDépHr×ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¬DHr»DDWDépHr×ð......Phase 3A@..DWGDWÐ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1007 10071607100716071007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDË4Hr»44DW©DÇ8Hs’¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDË4Hr»44DWDæ HrÖÿ DW’D®ØHss©ØDW©DÇ8Hs’¸Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071607100716071007.DW?B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDË4Hr»44DW©DÇ8Hs’¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDË4Hr»44DWDæ HrÖÿ DW’D®ØHss©ØDW©DÇ8Hs’¸Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071607100716071007DW’DW’BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDË4Hr»44DW©DÇ8Hs’¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDË4Hr»44DWDæ HrÖÿ DW’D®ØHss©ØDW©DÇ8Hs’¸Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071607100716071007.DWÊBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW?YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDË4Hr»44DW©DÇ8Hs’¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDË4Hr»44DWDæ HrÖÿ DW’D®ØHss©ØDW©DÇ8Hs’¸Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071608100716081007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÉÌHr»2ÌDW©DÆHs’ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÉÌHr»2ÌDWDçTHrÖÿÔDW’D¯ŒHssªŒDW©DÆHs’ŒPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071608100716081007.DW?B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÉÌHr»2ÌDW©DÆHs’ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÉÌHr»2ÌDWDçTHrÖÿÔDW’D¯ŒHssªŒDW©DÆHs’ŒPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071608100716081007DW’DW’BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÉÌHr»2ÌDW©DÆHs’ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÉÌHr»2ÌDWDçTHrÖÿÔDW’D¯ŒHssªŒDW©DÆHs’ŒPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071608100716081007.DWÊBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW?YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÉÌHr»2ÌDW©DÆHs’ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÉÌHr»2ÌDWDçTHrÖÿÔDW’D¯ŒHssªŒDW©DÆHs’ŒPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071609100716091007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÐ\Hr»9\DWDëÈHr×HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÐ\Hr»9\DWDëÈHr×H......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071609100716091007.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÐ\Hr»9\DWDëÈHr×HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÐ\Hr»9\DWDëÈHr×H......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071610100716101007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÓ.DW9 AðYEARSFA AMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÔHr»=DWDáHrÙœ€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW}BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÔHr»=DWDáHrÙœ€......Phase 3A@..DW9DWÓ12-15 YearsA YNY. DW|DWýDWýAðYEARSDSAC4591001C4591001 1007 10071610100716101007.DW9B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÓ.DW9 AðYEARSFA AMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÔHr»=DWDáHrÙœ€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW}BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÔHr»=DWDáHrÙœ€......Phase 3A@..DW9DWÓ12-15 YearsA YNY. DW|DWýDWýAðYEARSDSA C4591001C4591001 1007 10071612100716121007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÊ.DW@ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒðHr»;ðDWDãÐHrÖüPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒðHr»;ðDWDãÐHrÖüP......Phase 3A@..DW@DWÊ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071612100716121007.DW@B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÊ.DW@ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒðHr»;ðDWDãÐHrÖüPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒðHr»;ðDWDãÐHrÖüP......Phase 3A@..DW@DWÊ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071613100716131007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÊDW8 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDäHr»MDW®D‡Hs˜lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDäHr»MDWDÏ¨HrÖè(DW™D¥´Hs|Û4DW®D‡Hs˜lPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071613100716131007.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÊDW8 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDäHr»MDW®D‡Hs˜lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDäHr»MDWDÏ¨HrÖè(DW™D¥´Hs|Û4DW®D‡Hs˜lPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071613100716131007DW™DW™B”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÊDW8 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDäHr»MDW®D‡Hs˜lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDäHr»MDWDÏ¨HrÖè(DW™D¥´Hs|Û4DW®D‡Hs˜lPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071613100716131007.DWÊBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÊDW8YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDäHr»MDW®D‡Hs˜lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDäHr»MDWDÏ¨HrÖè(DW™D¥´Hs|Û4DW®D‡Hs˜lPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071614100716141007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW×DW> AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDê`Hr»S`DW»DÆüHs©Ï|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW».DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDê`Hr»S`DWDçHrÖÿ˜DW”DÓ,Hsvq,DW»DÆüHs©Ï|Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071614100716141007.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW×DW> AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDê`Hr»S`DW»DÆüHs©Ï|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW».DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDê`Hr»S`DWDçHrÖÿ˜DW”DÓ,Hsvq,DW»DÆüHs©Ï|Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071614100716141007DW”DW”BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW×DW> AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDê`Hr»S`DW»DÆüHs©Ï|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW».DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDê`Hr»S`DWDçHrÖÿ˜DW”DÓ,Hsvq,DW»DÆüHs©Ï|Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071614100716141007.DW×BÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW×DW>YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDê`Hr»S`DW»DÆüHs©Ï|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW».DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDê`Hr»S`DWDçHrÖÿ˜DW”DÓ,Hsvq,DW»DÆüHs©Ï|Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071615100716151007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÌ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDãÐHr»LÐDWDèøHr×xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDãÐHr»LÐDWDèøHr×x......Phase 3A@..DW>DWÌ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071615100716151007.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÌ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDãÐHr»LÐDWDèøHr×xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDãÐHr»LÐDWDèøHr×x......Phase 3A@..DW>DWÌ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071616100716161007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÙ.DW> AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèDHr»QDDWDÃ´HrÖÜ4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèDHr»QDDWDÃ´HrÖÜ4......Phase 3A@..DW>DWÙ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1007 10071616100716161007.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÙ.DW> AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèDHr»QDDWDÃ´HrÖÜ4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèDHr»QDDWDÃ´HrÖÜ4......Phase 3A@..DW>DWÙ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1007 10071617100716171007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¨DW8 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòXHr»[XDWŠDïÄHsi^ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWuDWŠ.DWjPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDòXHr»[XDWDâhHrØLhDWuDˆhHsMGèDWŠDïÄHsi^ÄPhase 3A@..DW8.12-15 YearsA YNN. DWiDWýDWýAðYEARSDSAC4591001C4591001 1007 10071617100716171007.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¨DW8 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòXHr»[XDWŠDïÄHsi^ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWuDWŠ.DWjPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDòXHr»[XDWDâhHrØLhDWuDˆhHsMGèDWŠDïÄHsi^ÄPhase 3A@..DW8.12-15 YearsA YNN. DWiDWýDWýAðYEARSDSA C4591001C4591001 1007 10071617100716171007DWuDWuBpREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¨DW8 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòXHr»[XDWŠDïÄHsi^ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWuDWŠ.DWjPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDòXHr»[XDWDâhHrØLhDWuDˆhHsMGèDWŠDïÄHsi^ÄPhase 3A@..DW8.12-15 YearsA YNN. DWiDWýDWýAðYEARSDSA0C4591001C4591001 1007 10071617100716171007.DW¨B£OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¨DW8YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòXHr»[XDWŠDïÄHsi^ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWuDWŠ.DWjPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDòXHr»[XDWDâhHrØLhDWuDˆhHsMGèDWŠDïÄHsi^ÄPhase 3A@..DW8.12-15 YearsA YNN. DWiDWýDWýAðYEARSDSA@C4591001C4591001 1007 10071618100716181007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DW×.DW? AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòHr»[DWD„0HrÖœ°Placebo Placebo 12-15 YearsA . . .DWDW....DWŒPlacebo Placebo Placebo A .Placebo A .DWDòHr»[DWD„0HrÖœ°......Phase 3A@..DW?DW×12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071618100716181007.DW?B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DW×.DW? AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòHr»[DWD„0HrÖœ°Placebo Placebo 12-15 YearsA . . .DWDW....DWŒPlacebo Placebo Placebo A .Placebo A .DWDòHr»[DWD„0HrÖœ°......Phase 3A@..DW?DW×12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071619100716191007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWË.DW? AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‰Hr¼CœDWD€¬Hr×ê¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‰Hr¼CœDWD€¬Hr×ê¬......Phase 3A@..DW?DWË12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071619100716191007.DW?B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWË.DW? AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‰Hr¼CœDWD€¬Hr×ê¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‰Hr¼CœDWD€¬Hr×ê¬......Phase 3A@..DW?DWË12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071620100716201007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWË.DW9 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD’¸Hr¼M8DWDèHrØRBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD’¸Hr¼M8DWDèHrØR......Phase 3A@..DW9DWË12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071620100716201007.DW9B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWË.DW9 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD’¸Hr¼M8DWDèHrØRBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD’¸Hr¼M8DWDèHrØR......Phase 3A@..DW9DWË12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071621100716211007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWË.DW9 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD—,Hr¼Q¬DWDè¼HrØR¼Placebo Placebo 12-15 YearsA . . .DWDW....DW‘Placebo Placebo Placebo A .Placebo A .DWD—,Hr¼Q¬DWDè¼HrØR¼......Phase 3A@..DW9DWË12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1007 10071621100716211007.DW9B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWË.DW9 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD—,Hr¼Q¬DWDè¼HrØR¼Placebo Placebo 12-15 YearsA . . .DWDW....DW‘Placebo Placebo Placebo A .Placebo A .DWD—,Hr¼Q¬DWDè¼HrØR¼......Phase 3A@..DW9DWË12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1007 10071622100716221007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWË.DW9 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD•ÄHr¼PDDWD•ÄHr¼PDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW.....DW6BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD•ÄHr¼PDDWD•ÄHr¼PD......Phase 3A@.DWDW9DWË12-15 YearsA YNN. DW5DWýDWýAðYEARSDSAC4591001C4591001 1007 10071622100716221007.DWBVACCINATION BDISPOSITION EVENTOTHER ApParticipant had COVID-19 prior to second vaccine DW9DWË.DW9 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD•ÄHr¼PDDWD•ÄHr¼PDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW.....DW6BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD•ÄHr¼PDDWD•ÄHr¼PD......Phase 3A@.DWDW9DWË12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071623100716231007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDštHr¼TôDWµDÇìHs¡çlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDštHr¼TôDWDçTHrÙ¢ÔDW DÜÈHs†LÈDWµDÇìHs¡çlPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071623100716231007.DW?B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDštHr¼TôDWµDÇìHs¡çlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDštHr¼TôDWDçTHrÙ¢ÔDW DÜÈHs†LÈDWµDÇìHs¡çlPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071623100716231007DW DW BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDštHr¼TôDWµDÇìHs¡çlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDštHr¼TôDWDçTHrÙ¢ÔDW DÜÈHs†LÈDWµDÇìHs¡çlPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071623100716231007.DWÑBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW?YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDštHr¼TôDWµDÇìHs¡çlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDštHr¼TôDWDçTHrÙ¢ÔDW DÜÈHs†LÈDWµDÇìHs¡çlPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071624100716241007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÄDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDª Hr¼e DW¦DË4HsŽ$4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDª Hr¼e DW"DŒdHrßßdDW“DÌØHsuXDW¦DË4HsŽ$4Phase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1007 10071624100716241007.DW>B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÄDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDª Hr¼e DW¦DË4HsŽ$4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDª Hr¼e DW"DŒdHrßßdDW“DÌØHsuXDW¦DË4HsŽ$4Phase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1007 10071624100716241007DW“DW“BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÄDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDª Hr¼e DW¦DË4HsŽ$4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDª Hr¼e DW"DŒdHrßßdDW“DÌØHsuXDW¦DË4HsŽ$4Phase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071624100716241007.DWÄB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÄDW>YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDª Hr¼e DW¦DË4HsŽ$4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDª Hr¼e DW"DŒdHrßßdDW“DÌØHsuXDW¦DË4HsŽ$4Phase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071625100716251007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÄDW> AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬¼Hr¼g<DW¦DÉÌHsŽ"ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬¼Hr¼g<DW"D‹tHrßÞtDW“DÌ$Hsu¤DW¦DÉÌHsŽ"ÌPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1007 10071625100716251007.DW>B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÄDW> AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬¼Hr¼g<DW¦DÉÌHsŽ"ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬¼Hr¼g<DW"D‹tHrßÞtDW“DÌ$Hsu¤DW¦DÉÌHsŽ"ÌPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1007 10071625100716251007DW“DW“BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÄDW> AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬¼Hr¼g<DW¦DÉÌHsŽ"ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬¼Hr¼g<DW"D‹tHrßÞtDW“DÌ$Hsu¤DW¦DÉÌHsŽ"ÌPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071625100716251007.DWÄB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÄDW>YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬¼Hr¼g<DW¦DÉÌHsŽ"ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬¼Hr¼g<DW"D‹tHrßÞtDW“DÌ$Hsu¤DW¦DÉÌHsŽ"ÌPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071626100716261007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÆHr¼€ŒDWD…˜Hr×ï˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÆHr¼€ŒDWD…˜Hr×ï˜......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071626100716261007.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÆHr¼€ŒDWD…˜Hr×ï˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÆHr¼€ŒDWD…˜Hr×ï˜......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071627100716271007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÒ.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌœHr¼‡DWD~Hr×èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌœHr¼‡DWD~Hr×è......Phase 3A@..DW8DWÒ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071627100716271007.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÒ.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌœHr¼‡DWD~Hr×èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌœHr¼‡DWD~Hr×è......Phase 3A@..DW8DWÒ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071628100716281007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÞ.DW= AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDãXHr¼ØDWDÆ„HrØ0„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDãXHr¼ØDWDÆ„HrØ0„......Phase 3A@..DW=DWÞ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071628100716281007.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÞ.DW= AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDãXHr¼ØDWDÆ„HrØ0„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDãXHr¼ØDWDÆ„HrØ0„......Phase 3A@..DW=DWÞ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071629100716291007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÝ|Hr¼—üDWµD°Hs¡Ï„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÝ|Hr¼—üDWDƒ@Hr×í@DW DÌœHs†<œDWµD°Hs¡Ï„Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1007 10071629100716291007.DW?B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÝ|Hr¼—üDWµD°Hs¡Ï„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÝ|Hr¼—üDWDƒ@Hr×í@DW DÌœHs†<œDWµD°Hs¡Ï„Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1007 10071629100716291007DW DW BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÝ|Hr¼—üDWµD°Hs¡Ï„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÝ|Hr¼—üDWDƒ@Hr×í@DW DÌœHs†<œDWµD°Hs¡Ï„Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1007 10071629100716291007.DWÑBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW?YAðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÝ|Hr¼—üDWµD°Hs¡Ï„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÝ|Hr¼—üDWDƒ@Hr×í@DW DÌœHs†<œDWµD°Hs¡Ï„Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1007 10071630100716301007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÜHr¼–”DWµD±¨Hs¡Ñ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜHr¼–”DWD‚ŒHr×ìŒDW DÎôHs†>ôDWµD±¨Hs¡Ñ(Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071630100716301007.DW?B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÜHr¼–”DWµD±¨Hs¡Ñ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜHr¼–”DWD‚ŒHr×ìŒDW DÎôHs†>ôDWµD±¨Hs¡Ñ(Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071630100716301007DW DW BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÜHr¼–”DWµD±¨Hs¡Ñ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜHr¼–”DWD‚ŒHr×ìŒDW DÎôHs†>ôDWµD±¨Hs¡Ñ(Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071630100716301007.DWÑBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW?YAÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÜHr¼–”DWµD±¨Hs¡Ñ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜHr¼–”DWD‚ŒHr×ìŒDW DÎôHs†>ôDWµD±¨Hs¡Ñ(Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071631100716311007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÌ.DW@ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDçHr¼¡˜DWDáðHrÙpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDçHr¼¡˜DWDáðHrÙp......Phase 3A@..DW@DWÌ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071631100716311007.DW@B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÌ.DW@ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDçHr¼¡˜DWDáðHrÙpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDçHr¼¡˜DWDáðHrÙp......Phase 3A@..DW@DWÌ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071632100716321007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDëŒHr¼¦DW§DŽ€Hs9Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëŒHr¼¦DWD¢lHrÙ]ìDW’D‘PHssŒPDW§DŽ€Hs9Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071632100716321007.DW?B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDëŒHr¼¦DW§DŽ€Hs9Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëŒHr¼¦DWD¢lHrÙ]ìDW’D‘PHssŒPDW§DŽ€Hs9Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071632100716321007DW’DW’BŒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDëŒHr¼¦DW§DŽ€Hs9Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëŒHr¼¦DWD¢lHrÙ]ìDW’D‘PHssŒPDW§DŽ€Hs9Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071632100716321007.DWÄB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW?YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDëŒHr¼¦DW§DŽ€Hs9Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëŒHr¼¦DWD¢lHrÙ]ìDW’D‘PHssŒPDW§DŽ€Hs9Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071633100716331007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÌ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDêœHr¼¥DWDäüHrÙ |BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDêœHr¼¥DWDäüHrÙ |......Phase 3A@..DW>DWÌ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071633100716331007.DW>B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÌ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDêœHr¼¥DWDäüHrÙ |BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDêœHr¼¥DWDäüHrÙ |......Phase 3A@..DW>DWÌ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071634100716341007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD”˜HrÂæ˜DW!DšìHrÞœlBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD”˜HrÂæ˜DW!DšìHrÞœl......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071634100716341007.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD”˜HrÂæ˜DW!DšìHrÞœlBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD”˜HrÂæ˜DW!DšìHrÞœl......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071635100716351007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=..DW= AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽ¼HrÂà¼DW!DÅÐHrÞÇPPlacebo Placebo 12-15 YearsA . . .DWDW!....DWŒPlacebo Placebo Placebo A .Placebo A .DWDŽ¼HrÂà¼DW!DÅÐHrÞÇP......Phase 3A@DWŒ.DW=.12-15 YearsA YNN. DW‹DWŒDWŒAÐYEARSDSAC4591001C4591001 1007 10071635100716351007.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=..DW= AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽ¼HrÂà¼DW!DÅÐHrÞÇPPlacebo Placebo 12-15 YearsA . . .DWDW!....DWŒPlacebo Placebo Placebo A .Placebo A .DWDŽ¼HrÂà¼DW!DÅÐHrÞÇP......Phase 3A@DWŒ.DW=.12-15 YearsA YNN. DW‹DWŒDWŒAÐYEARSDSA C4591001C4591001 1007 10071635100716351007.DWŒBFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BPfizer vaccine outside of study, participant verbalized wanting to withdrawal from the study DW=..DW=YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽ¼HrÂà¼DW!DÅÐHrÞÇPPlacebo Placebo 12-15 YearsA . . .DWDW!....DWŒPlacebo Placebo Placebo A .Placebo A .DWDŽ¼HrÂà¼DW!DÅÐHrÞÇP......Phase 3A@DWŒ.DW=.12-15 YearsA YNN. DW‹DWŒDWŒAÐYEARSDSApC4591001C4591001 1007 10071636100716361007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŸœHrÂñœDW!DŒ HrÞŽ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŸœHrÂñœDW!DŒ HrÞŽ ......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071636100716361007.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŸœHrÂñœDW!DŒ HrÞŽ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŸœHrÂñœDW!DŒ HrÞŽ ......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071638100716381007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¥<HrÂ÷<DW!D†HrÞ‡BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¥<HrÂ÷<DW!D†HrÞ‡......Phase 3A@..DW?DWÞ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071638100716381007.DW?B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¥<HrÂ÷<DW!D†HrÞ‡BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¥<HrÂ÷<DW!D†HrÞ‡......Phase 3A@..DW?DWÞ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071639100716391007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD..DWD AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD«HrÂýDW!D€4HrÞ´Placebo Placebo 12-15 YearsA . . .DWDW!....DWPlacebo Placebo Placebo A .Placebo A .DWD«HrÂýDW!D€4HrÞ´......Phase 3A@DW .DWD.12-15 YearsA YNN. DWŒDW DW AÐYEARSDSAC4591001C4591001 1007 10071639100716391007.DWDB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD..DWD AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD«HrÂýDW!D€4HrÞ´Placebo Placebo 12-15 YearsA . . .DWDW!....DWPlacebo Placebo Placebo A .Placebo A .DWD«HrÂýDW!D€4HrÞ´......Phase 3A@DW .DWD.12-15 YearsA YNN. DWŒDW DW AÐYEARSDSA C4591001C4591001 1007 10071639100716391007.DW B•FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BParticipant Moving DWD..DWDYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD«HrÂýDW!D€4HrÞ´Placebo Placebo 12-15 YearsA . . .DWDW!....DWPlacebo Placebo Placebo A .Placebo A .DWD«HrÂýDW!D€4HrÞ´......Phase 3A@DW .DWD.12-15 YearsA YNN. DWŒDW DW AÐYEARSDSApC4591001C4591001 1007 10071640100716401007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÒDWE AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½ØHrÃØDWµDÄhHs¡ãèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½ØHrÃØDW!DäÀHrÞæ@DW¢DÃHsˆÖDWµDÄhHs¡ãèPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071640100716401007.DWEB:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÒDWE AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½ØHrÃØDWµDÄhHs¡ãèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½ØHrÃØDW!DäÀHrÞæ@DW¢DÃHsˆÖDWµDÄhHs¡ãèPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071640100716401007DW¢DW¢B—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÒDWE AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½ØHrÃØDWµDÄhHs¡ãèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½ØHrÃØDW!DäÀHrÞæ@DW¢DÃHsˆÖDWµDÄhHs¡ãèPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1007 10071640100716401007.DWÒBÇOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÒDWEYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½ØHrÃØDWµDÄhHs¡ãèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½ØHrÃØDW!DäÀHrÞæ@DW¢DÃHsˆÖDWµDÄhHs¡ãèPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1007 10071641100716411007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DW×.DW? AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÈ(HrÃ(DW"DÚèHrà-èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÈ(HrÃ(DW"DÚèHrà-è......Phase 3A@..DW?DW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1007 10071641100716411007.DW?B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DW×.DW? AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÈ(HrÃ(DW"DÚèHrà-èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÈ(HrÃ(DW"DÚèHrà-è......Phase 3A@..DW?DW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1007 10071642100716421007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÙ.DW= AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÓ,HrÃ%,DW›DÎ¸Hs§8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW.DW›...DWBNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÓ,HrÃ%,DW›DÎ¸Hs§8......Phase 3A@..DW=DWÙ12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1007 10071642100716421007.DW¾B³VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÙ.DW= AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÓ,HrÃ%,DW›DÎ¸Hs§8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW.DW›...DWBNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÓ,HrÃ%,DW›DÎ¸Hs§8......Phase 3A@..DW=DWÙ12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1007 10071643100716431007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÓDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑÄHrÃ#ÄDW·D€Hs¤`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW›DW·.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑÄHrÃ#ÄDW!DÖìHrÞØlDW›DÐ˜Hs©DW·D€Hs¤`Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071643100716431007.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÓDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑÄHrÃ#ÄDW·D€Hs¤`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW›DW·.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑÄHrÃ#ÄDW!DÖìHrÞØlDW›DÐ˜Hs©DW·D€Hs¤`Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071643100716431007DW›DW›BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÓDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑÄHrÃ#ÄDW·D€Hs¤`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW›DW·.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑÄHrÃ#ÄDW!DÖìHrÞØlDW›DÐ˜Hs©DW·D€Hs¤`Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071643100716431007.DWÓBÈOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÓDW=YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑÄHrÃ#ÄDW·D€Hs¤`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW›DW·.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑÄHrÃ#ÄDW!DÖìHrÞØlDW›DÐ˜Hs©DW·D€Hs¤`Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071644100716441007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDépHrÃ;pDW!DÚèHrÞÜhBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDépHrÃ;pDW!DÚèHrÞÜh......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071644100716441007.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDépHrÃ;pDW!DÚèHrÞÜhBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDépHrÃ;pDW!DÚèHrÞÜh......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071645100716451007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWËDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæ(HrÃ8(DW¯D’Hs™È„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæ(HrÃ8(DW!Dá´HrÞã4DWšD§Hs~.DW¯D’Hs™È„Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071645100716451007.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWËDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæ(HrÃ8(DW¯D’Hs™È„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæ(HrÃ8(DW!Dá´HrÞã4DWšD§Hs~.DW¯D’Hs™È„Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071645100716451007DWšDWšBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWËDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæ(HrÃ8(DW¯D’Hs™È„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæ(HrÃ8(DW!Dá´HrÞã4DWšD§Hs~.DW¯D’Hs™È„Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071645100716451007.DWËBÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWËDW=YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæ(HrÃ8(DW¯D’Hs™È„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWšDW¯.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæ(HrÃ8(DW!Dá´HrÞã4DWšD§Hs~.DW¯D’Hs™È„Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071646100716461007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÑDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDñ,HrÃC,DWµDØTHs¡÷ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDñ,HrÃC,DW!DàLHrÞáÌDW¢DÍPHsˆàPDWµDØTHs¡÷ÔPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071646100716461007.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÑDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDñ,HrÃC,DWµDØTHs¡÷ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDñ,HrÃC,DW!DàLHrÞáÌDW¢DÍPHsˆàPDWµDØTHs¡÷ÔPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071646100716461007DW¢DW¢B—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÑDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDñ,HrÃC,DWµDØTHs¡÷ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDñ,HrÃC,DW!DàLHrÞáÌDW¢DÍPHsˆàPDWµDØTHs¡÷ÔPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071646100716461007.DWÑBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÑDW=YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDñ,HrÃC,DWµDØTHs¡÷ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW¢DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDñ,HrÃC,DW!DàLHrÞáÌDW¢DÍPHsˆàPDWµDØTHs¡÷ÔPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071647100716471007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÐ.DW@ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDó„HrÃE„DW!DÖìHrÞØlBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDó„HrÃE„DW!DÖìHrÞØl......Phase 3A@..DW@DWÐ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1007 10071647100716471007.DW@B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÐ.DW@ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDó„HrÃE„DW!DÖìHrÞØlBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDó„HrÃE„DW!DÖìHrÞØl......Phase 3A@..DW@DWÐ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1007 10071648100716481007DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW§DW> AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DW D„äHrÄ(dDW‹D¨ÀHsji@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWvDW‹.DWuPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D„äHrÄ(dDW"DøHrßÒøDWvD±¨HsNÂ¨DW‹D¨ÀHsji@Phase 3A@..DW>.12-15 YearsA YNN. DWtDWýDWýAðYEARSDSAC4591001C4591001 1007 10071648100716481007.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW§DW> AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DW D„äHrÄ(dDW‹D¨ÀHsji@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWvDW‹.DWuPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D„äHrÄ(dDW"DøHrßÒøDWvD±¨HsNÂ¨DW‹D¨ÀHsji@Phase 3A@..DW>.12-15 YearsA YNN. DWtDWýDWýAðYEARSDSA C4591001C4591001 1007 10071648100716481007DWvDWvBjREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW§DW> AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DW D„äHrÄ(dDW‹D¨ÀHsji@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWvDW‹.DWuPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D„äHrÄ(dDW"DøHrßÒøDWvD±¨HsNÂ¨DW‹D¨ÀHsji@Phase 3A@..DW>.12-15 YearsA YNN. DWtDWýDWýAðYEARSDSA0C4591001C4591001 1007 10071648100716481007.DW§B›OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW§DW>YAðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DW D„äHrÄ(dDW‹D¨ÀHsji@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWvDW‹.DWuPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D„äHrÄ(dDW"DøHrßÒøDWvD±¨HsNÂ¨DW‹D¨ÀHsji@Phase 3A@..DW>.12-15 YearsA YNN. DWtDWýDWýAðYEARSDSA@C4591001C4591001 1007 10071649100716491007DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D‹tHrÄ.ôDW"DÖìHrà)ìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D‹tHrÄ.ôDW"DÖìHrà)ì......Phase 3A@..DW>DWÑ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071649100716491007.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D‹tHrÄ.ôDW"DÖìHrà)ìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D‹tHrÄ.ôDW"DÖìHrà)ì......Phase 3A@..DW>DWÑ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071650100716501007DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÊDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DœÌHrÄ@LDW®DÍHs˜²Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DœÌHrÄ@LDW"D†HrßÙDW™DËpHs}ðDW®DÍHs˜²Phase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071650100716501007.DW@B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÊDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DœÌHrÄ@LDW®DÍHs˜²Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DœÌHrÄ@LDW"D†HrßÙDW™DËpHs}ðDW®DÍHs˜²Phase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071650100716501007DW™DW™BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÊDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DœÌHrÄ@LDW®DÍHs˜²Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DœÌHrÄ@LDW"D†HrßÙDW™DËpHs}ðDW®DÍHs˜²Phase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071650100716501007.DWÊB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÊDW@YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DœÌHrÄ@LDW®DÍHs˜²Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DœÌHrÄ@LDW"D†HrßÙDW™DËpHs}ðDW®DÍHs˜²Phase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071651100716511007DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÓ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D™„HrÄ=DW"D—àHrßêàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D™„HrÄ=DW"D—àHrßêà......Phase 3A@..DW>DWÓ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071651100716511007.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÓ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D™„HrÄ=DW"D—àHrßêàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D™„HrÄ=DW"D—àHrßêà......Phase 3A@..DW>DWÓ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071652100716521007DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÐDW> AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dž¬HrÄB,DW´Dž¬Hs l¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW™DW´.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dž¬HrÄB,DW"D…\HrßØ\DW™D‘ÈHs|ÇHDW´Dž¬Hs l¬Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071652100716521007.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÐDW> AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dž¬HrÄB,DW´Dž¬Hs l¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW™DW´.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dž¬HrÄB,DW"D…\HrßØ\DW™D‘ÈHs|ÇHDW´Dž¬Hs l¬Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071652100716521007DW™DW™BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÐDW> AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dž¬HrÄB,DW´Dž¬Hs l¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW™DW´.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dž¬HrÄB,DW"D…\HrßØ\DW™D‘ÈHs|ÇHDW´Dž¬Hs l¬Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071652100716521007.DWÐBÄOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÐDW>YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dž¬HrÄB,DW´Dž¬Hs l¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW™DW´.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dž¬HrÄB,DW"D…\HrßØ\DW™D‘ÈHs|ÇHDW´Dž¬Hs l¬Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071653100716531007DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÊ¼HrÄn<DW"DÎ¸Hrà!¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÊ¼HrÄn<DW"DÎ¸Hrà!¸......Phase 3A@..DW>DWÑ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1007 10071653100716531007.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÊ¼HrÄn<DW"DÎ¸Hrà!¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÊ¼HrÄn<DW"DÎ¸Hrà!¸......Phase 3A@..DW>DWÑ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1007 10071654100716541007DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÓ.DW> AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÈ(HrÄk¨DW"DÏäHrà"äPlacebo Placebo 12-15 YearsA . . .DW DW"....DWŒPlacebo Placebo Placebo A .Placebo A .DW DÈ(HrÄk¨DW"DÏäHrà"ä......Phase 3A@....12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071654100716541007.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÓ.DW> AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÈ(HrÄk¨DW"DÏäHrà"äPlacebo Placebo 12-15 YearsA . . .DW DW"....DWŒPlacebo Placebo Placebo A .Placebo A .DW DÈ(HrÄk¨DW"DÏäHrà"ä......Phase 3A@....12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071655100716551007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD†ÄHrÅ{ÄDW¦DâhHsŽ;hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD†ÄHrÅ{ÄDW#D†LHrá*ÌDW‘DÙ¼Hsrƒ<DW¦DâhHsŽ;hPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1007 10071655100716551007.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD†ÄHrÅ{ÄDW¦DâhHsŽ;hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD†ÄHrÅ{ÄDW#D†LHrá*ÌDW‘DÙ¼Hsrƒ<DW¦DâhHsŽ;hPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1007 10071655100716551007DW‘DW‘B„REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD†ÄHrÅ{ÄDW¦DâhHsŽ;hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD†ÄHrÅ{ÄDW#D†LHrá*ÌDW‘DÙ¼Hsrƒ<DW¦DâhHsŽ;hPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1007 10071655100716551007.DWÃB¶OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW?YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD†ÄHrÅ{ÄDW¦DâhHsŽ;hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD†ÄHrÅ{ÄDW#D†LHrá*ÌDW‘DÙ¼Hsrƒ<DW¦DâhHsŽ;hPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1007 10071656100716561007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèHrÅ„èDW#DÒHráv€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèHrÅ„èDW#DÒHráv€......Phase 3A@..DWEDWØ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1007 10071656100716561007.DWEB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèHrÅ„èDW#DÒHráv€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèHrÅ„èDW#DÒHráv€......Phase 3A@..DWEDWØ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1007 10071658100716581007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÉDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDñàHrÅæàDW¦DÔÐHsŽ-ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDñàHrÅæàDW#D”˜Hrá9DW‘DÖìHsr€lDW¦DÔÐHsŽ-ÐPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071658100716581007.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÉDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDñàHrÅæàDW¦DÔÐHsŽ-ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDñàHrÅæàDW#D”˜Hrá9DW‘DÖìHsr€lDW¦DÔÐHsŽ-ÐPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071658100716581007DW‘DW‘B„REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÉDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDñàHrÅæàDW¦DÔÐHsŽ-ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDñàHrÅæàDW#D”˜Hrá9DW‘DÖìHsr€lDW¦DÔÐHsŽ-ÐPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1007 10071658100716581007.DWÉB¼OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÉDW?YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDñàHrÅæàDW¦DÔÐHsŽ-ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDñàHrÅæàDW#D”˜Hrá9DW‘DÖìHsr€lDW¦DÔÐHsŽ-ÐPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1007 10071659100716591007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDî\HrÅã\DW#DàHrá„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDî\HrÅã\DW#DàHrá„......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1007 10071659100716591007.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDî\HrÅã\DW#DàHrá„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDî\HrÅã\DW#DàHrá„......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1007 10071660100716601007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÓDW? AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDílHrÅâlDW·DÌ$Hs¤Ž¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW¡DW·.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDílHrÅâlDW#Dß\HráƒÜDW¡D¯ŒHs‡qDW·DÌ$Hs¤Ž¤Phase 3A@..DW?.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1007 10071660100716601007.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÓDW? AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDílHrÅâlDW·DÌ$Hs¤Ž¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW¡DW·.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDílHrÅâlDW#Dß\HráƒÜDW¡D¯ŒHs‡qDW·DÌ$Hs¤Ž¤Phase 3A@..DW?.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1007 10071660100716601007DW¡DW¡B”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÓDW? AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDílHrÅâlDW·DÌ$Hs¤Ž¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW¡DW·.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDílHrÅâlDW#Dß\HráƒÜDW¡D¯ŒHs‡qDW·DÌ$Hs¤Ž¤Phase 3A@..DW?.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA0C4591001C4591001 1007 10071660100716601007.DWÓBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÓDW?YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDílHrÅâlDW·DÌ$Hs¤Ž¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW¡DW·.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDílHrÅâlDW#Dß\HráƒÜDW¡D¯ŒHs‡qDW·DÌ$Hs¤Ž¤Phase 3A@..DW?.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA@C4591001C4591001 1007 10071661100716611007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙøHrÇ xDW$DâhHrâØhBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙøHrÇ xDW$DâhHrâØh......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1007 10071661100716611007.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙøHrÇ xDW$DâhHrâØhBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙøHrÇ xDW$DâhHrâØh......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1007 10071662100716621007DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWè.DW@ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÇ)$DW$D†LHrâ|LPlacebo Placebo 12-15 YearsA . . .DWDW$....DWPlacebo Placebo Placebo A .Placebo A .DWDâ¤HrÇ)$DW$D†LHrâ|L......Phase 3A@..DW@DWè12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1007 10071662100716621007.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWè.DW@ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÇ)$DW$D†LHrâ|LPlacebo Placebo 12-15 YearsA . . .DWDW$....DWPlacebo Placebo Placebo A .Placebo A .DWDâ¤HrÇ)$DW$D†LHrâ|L......Phase 3A@..DW@DWè12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1008 10081751100817511008DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD› Hr– DW£DŽDHs‰òÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD› Hr– DWD“0Hr³0DWŽDÇ°Hsn|°DW£DŽDHs‰òÄPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081751100817511008.DW!B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD› Hr– DW£DŽDHs‰òÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD› Hr– DWD“0Hr³0DWŽDÇ°Hsn|°DW£DŽDHs‰òÄPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081751100817511008DWŽDWŽB¥REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD› Hr– DW£DŽDHs‰òÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD› Hr– DWD“0Hr³0DWŽDÇ°Hsn|°DW£DŽDHs‰òÄPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081751100817511008.DW¿BÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW!YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD› Hr– DW£DŽDHs‰òÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD› Hr– DWD“0Hr³0DWŽDÇ°Hsn|°DW£DŽDHs‰òÄPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081752100817521008DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¿DW AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVêDÙHr–XDW£DÂˆHsŠ'Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDÙHr–XDVÿDÔÐHr²PDWD‡Hslê€DW£DÂˆHsŠ'Phase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081752100817521008.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¿DW AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVêDÙHr–XDW£DÂˆHsŠ'Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDÙHr–XDVÿDÔÐHr²PDWD‡Hslê€DW£DÂˆHsŠ'Phase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081752100817521008DWDWB¤REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¿DW AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVêDÙHr–XDW£DÂˆHsŠ'Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDÙHr–XDVÿDÔÐHr²PDWD‡Hslê€DW£DÂˆHsŠ'Phase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081752100817521008.DW¿BÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¿DWYAðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVêDÙHr–XDW£DÂˆHsŠ'Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDÙHr–XDVÿDÔÐHr²PDWD‡Hslê€DW£DÂˆHsŠ'Phase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081753100817531008DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÙDHr–XDDVÿDÔHr²œBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÙDHr–XDDVÿDÔHr²œ......Phase 3A@..DWDW°12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081753100817531008.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÙDHr–XDDVÿDÔHr²œBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÙDHr–XDDVÿDÔHr²œ......Phase 3A@..DWDW°12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081754100817541008DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDÂˆHr—“DVÿD|8Hr±ª¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDÂˆHr—“DVÿD|8Hr±ª¸......Phase 3A@..DWDW¯12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081754100817541008.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDÂˆHr—“DVÿD|8Hr±ª¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDÂˆHr—“DVÿD|8Hr±ª¸......Phase 3A@..DWDW¯12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081755100817551008DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDÄ,Hr—”¬DWDš°Hr³°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DWoBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDÄ,Hr—”¬DWDš°Hr³°......Phase 3A@..DWDW°12-15 YearsA YNY. DWnDWýDWýAðYEARSDSAC4591001C4591001 1008 10081755100817551008.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDÄ,Hr—”¬DWDš°Hr³°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DWoBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDÄ,Hr—”¬DWDš°Hr³°......Phase 3A@..DWDW°12-15 YearsA YNY. DWnDWýDWýAðYEARSDSA C4591001C4591001 1008 10081756100817561008DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÊ¼Hr—›<DWŒDÔÐHskæÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DWxDWŒ.DWwPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÊ¼Hr—›<DVÿDÖ°Hr²0DWxDÖ8HsQŠ8DWŒDÔÐHskæÐPhase 3A@..DW.12-15 YearsA YNN. DWvDWýDWýAðYEARSDSAC4591001C4591001 1008 10081756100817561008.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÊ¼Hr—›<DWŒDÔÐHskæÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DWxDWŒ.DWwPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÊ¼Hr—›<DVÿDÖ°Hr²0DWxDÖ8HsQŠ8DWŒDÔÐHskæÐPhase 3A@..DW.12-15 YearsA YNN. DWvDWýDWýAðYEARSDSA C4591001C4591001 1008 10081756100817561008DWxDWxBŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÊ¼Hr—›<DWŒDÔÐHskæÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DWxDWŒ.DWwPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÊ¼Hr—›<DVÿDÖ°Hr²0DWxDÖ8HsQŠ8DWŒDÔÐHskæÐPhase 3A@..DW.12-15 YearsA YNN. DWvDWýDWýAðYEARSDSA0C4591001C4591001 1008 10081756100817561008.DWBÃOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWDWYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÊ¼Hr—›<DWŒDÔÐHskæÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DWxDWŒ.DWwPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÊ¼Hr—›<DVÿDÖ°Hr²0DWxDÖ8HsQŠ8DWŒDÔÐHskæÐPhase 3A@..DW.12-15 YearsA YNN. DWvDWýDWýAðYEARSDSA@C4591001C4591001 1008 10081757100817571008DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÊHr—šˆDW¦D¡HsúPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÊHr—šˆDVÿDÕüHr²|DW‘DÃ´Hsrm4DW¦D¡HsúPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081757100817571008.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÊHr—šˆDW¦D¡HsúPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÊHr—šˆDVÿDÕüHr²|DW‘DÃ´Hsrm4DW¦D¡HsúPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081757100817571008DW‘DW‘B§REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÊHr—šˆDW¦D¡HsúPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÊHr—šˆDVÿDÕüHr²|DW‘DÃ´Hsrm4DW¦D¡HsúPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081757100817571008.DWÄBÚOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDWYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÊHr—šˆDW¦D¡HsúPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÊHr—šˆDVÿDÕüHr²|DW‘DÃ´Hsrm4DW¦D¡HsúPhase 3A@..DW.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081758100817581008DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW·.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDÔHr—¤œDWD”ÔHr³ÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDÔHr—¤œDWD”ÔHr³Ô......Phase 3A@DWÞ.DW!DW·12-15 YearsA YNY. DW‹DWÞDWÞAðYEARSDSAC4591001C4591001 1008 10081758100817581008.DW!B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW·.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDÔHr—¤œDWD”ÔHr³ÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDÔHr—¤œDWD”ÔHr³Ô......Phase 3A@DWÞ.DW!DW·12-15 YearsA YNY. DW‹DWÞDWÞAðYEARSDSA C4591001C4591001 1008 10081758100817581008.DWÞBôFOLLOW-UP BDISPOSITION EVENTOTHER ApParticipant enrolled in C4591031 DW!DW·.DW!YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDÔHr—¤œDWD”ÔHr³ÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDÔHr—¤œDWD”ÔHr³Ô......Phase 3A@DWÞ.DW!DW·12-15 YearsA YNY. DW‹DWÞDWÞAðYEARSDSAPC4591001C4591001 1008 10081760100817601008DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¾.DW" AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDß\HržG\DWDDHr¹´ÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDß\HržG\DWDDHr¹´Ä......Phase 3A@..DW"DW¾12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081760100817601008.DW"B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¾.DW" AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDß\HržG\DWDDHr¹´ÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDß\HržG\DWDDHr¹´Ä......Phase 3A@..DW"DW¾12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081761100817611008DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DW™DW% AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÒðHrž:ðDW}DÒHsX€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWgDW}.DWgPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÒðHrž:ðDWD’ôHr¹ªtDWgDØHs;"˜DW}DÒHsX€Phase 3A@..DW%.12-15 YearsA YNN. DWfDWýDWýAðYEARSDSAC4591001C4591001 1008 10081761100817611008.DW%B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DW™DW% AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÒðHrž:ðDW}DÒHsX€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWgDW}.DWgPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÒðHrž:ðDWD’ôHr¹ªtDWgDØHs;"˜DW}DÒHsX€Phase 3A@..DW%.12-15 YearsA YNN. DWfDWýDWýAðYEARSDSA C4591001C4591001 1008 10081761100817611008DWgDWgBxREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DW™DW% AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÒðHrž:ðDW}DÒHsX€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWgDW}.DWgPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÒðHrž:ðDWD’ôHr¹ªtDWgDØHs;"˜DW}DÒHsX€Phase 3A@..DW%.12-15 YearsA YNN. DWfDWýDWýAðYEARSDSA0C4591001C4591001 1008 10081761100817611008.DW™BªOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DW™DW%YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÒðHrž:ðDW}DÒHsX€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWgDW}.DWgPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÒðHrž:ðDWD’ôHr¹ªtDWgDØHs;"˜DW}DÒHsX€Phase 3A@..DW%.12-15 YearsA YNN. DWfDWýDWýAðYEARSDSA@C4591001C4591001 1008 10081763100817631008DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÅDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDçHržODW¨DÀäHs¼äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDçHržODWD·üHr¼r|DW“DÄ¤Hsu$DW¨DÀäHs¼äPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081763100817631008.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÅDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDçHržODW¨DÀäHs¼äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDçHržODWD·üHr¼r|DW“DÄ¤Hsu$DW¨DÀäHs¼äPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081763100817631008DW“DW“B¤REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÅDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDçHržODW¨DÀäHs¼äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDçHržODWD·üHr¼r|DW“DÄ¤Hsu$DW¨DÀäHs¼äPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081763100817631008.DWÅBÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÅDW!YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDçHržODW¨DÀäHs¼äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDçHržODWD·üHr¼r|DW“DÄ¤Hsu$DW¨DÀäHs¼äPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081764100817641008DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¸.DW! AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDædHržNdDWD ÈHr¼[HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDædHržNdDWD ÈHr¼[H......Phase 3A@..DW!DW¸12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081764100817641008.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¸.DW! AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDædHržNdDWD ÈHr¼[HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDædHržNdDWD ÈHr¼[H......Phase 3A@..DW!DW¸12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081767100817671008DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DW¾DW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÍHrŸ†”DW¢D¼¬HsˆÏ¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDÍHrŸ†”DWDèHrºøèDWDëŒHsmODW¢D¼¬HsˆÏ¬Phase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081767100817671008.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DW¾DW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÍHrŸ†”DW¢D¼¬HsˆÏ¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDÍHrŸ†”DWDèHrºøèDWDëŒHsmODW¢D¼¬HsˆÏ¬Phase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081767100817671008DWDWBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DW¾DW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÍHrŸ†”DW¢D¼¬HsˆÏ¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDÍHrŸ†”DWDèHrºøèDWDëŒHsmODW¢D¼¬HsˆÏ¬Phase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081767100817671008.DW¾BÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DW¾DW"YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÍHrŸ†”DW¢D¼¬HsˆÏ¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDÍHrŸ†”DWDèHrºøèDWDëŒHsmODW¢D¼¬HsˆÏ¬Phase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081768100817681008DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¼.DW% AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÑHrŸŠDWD½œHr»&œPlacebo Placebo 12-15 YearsA . . .DVñDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVñDÑHrŸŠDWD½œHr»&œ......Phase 3A@..DW%DW¼12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081768100817681008.DW%B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¼.DW% AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÑHrŸŠDWD½œHr»&œPlacebo Placebo 12-15 YearsA . . .DVñDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVñDÑHrŸŠDWD½œHr»&œ......Phase 3A@..DW%DW¼12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081769100817691008DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DW¿.DW> AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÔÐHrŸŽPDWD•ÄHrºþÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWvBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÔÐHrŸŽPDWD•ÄHrºþÄ......Phase 3A@..DW>DW¿12-15 YearsA YNY. DWuDWýDWýAðYEARSDSAC4591001C4591001 1008 10081769100817691008.DW>BNVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DW¿.DW> AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÔÐHrŸŽPDWD•ÄHrºþÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWvBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÔÐHrŸŽPDWD•ÄHrºþÄ......Phase 3A@..DW>DW¿12-15 YearsA YNY. DWuDWýDWýAðYEARSDSA C4591001C4591001 1008 10081770100817701008DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD™üHr ¤üDWD¢äHr¼]dBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD™üHr ¤üDWD¢äHr¼]d......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081770100817701008.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD™üHr ¤üDWD¢äHr¼]dBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD™üHr ¤üDWD¢äHr¼]d......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081771100817711008DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD˜XHr £XDWD£˜Hr¼^BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD˜XHr £XDWD£˜Hr¼^......Phase 3A@..DW#DW¶12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081771100817711008.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD˜XHr £XDWD£˜Hr¼^BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD˜XHr £XDWD£˜Hr¼^......Phase 3A@..DW#DW¶12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081773100817731008DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¿DW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÈ(Hr Ó(DW£DžèHsŠhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÈ(Hr Ó(DWD¤Hr» DWŽD«Hsn`DW£DžèHsŠhPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081773100817731008.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¿DW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÈ(Hr Ó(DW£DžèHsŠhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÈ(Hr Ó(DWD¤Hr» DWŽD«Hsn`DW£DžèHsŠhPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081773100817731008DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¿DW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÈ(Hr Ó(DW£DžèHsŠhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÈ(Hr Ó(DWD¤Hr» DWŽD«Hsn`DW£DžèHsŠhPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081773100817731008.DW¿BÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¿DW#YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÈ(Hr Ó(DW£DžèHsŠhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÈ(Hr Ó(DWD¤Hr» DWŽD«Hsn`DW£DžèHsŠhPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081774100817741008DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW½.DW$ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÒðHr ÝðDWDª(Hr¹Á¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÒðHr ÝðDWDª(Hr¹Á¨......Phase 3A@..DW$DW½12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081774100817741008.DW$B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW½.DW$ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÒðHr ÝðDWDª(Hr¹Á¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÒðHr ÝðDWDª(Hr¹Á¨......Phase 3A@..DW$DW½12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081775100817751008DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÒ<Hr Ý<DW±DÍÈHsœ§HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW•DW±.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÒ<Hr Ý<DWD©8Hr¹À¸DW•DÈ Hsw¸ DW±DÍÈHsœ§HPhase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081775100817751008.DW$B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÒ<Hr Ý<DW±DÍÈHsœ§HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW•DW±.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÒ<Hr Ý<DWD©8Hr¹À¸DW•DÈ Hsw¸ DW±DÍÈHsœ§HPhase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081775100817751008DW•DW•B¤REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÒ<Hr Ý<DW±DÍÈHsœ§HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW•DW±.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÒ<Hr Ý<DWD©8Hr¹À¸DW•DÈ Hsw¸ DW±DÍÈHsœ§HPhase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081775100817751008.DWÍBÜOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÒ<Hr Ý<DW±DÍÈHsœ§HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW•DW±.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÒ<Hr Ý<DWD©8Hr¹À¸DW•DÈ Hsw¸ DW±DÍÈHsœ§HPhase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081777100817771008DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW».DW$ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDŸØHr¡üXDWD„äHr½äBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDŸØHr¡üXDWD„äHr½ä......Phase 3A@..DW$DW»12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081777100817771008.DW$B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW».DW$ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDŸØHr¡üXDWD„äHr½äBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDŸØHr¡üXDWD„äHr½ä......Phase 3A@..DW$DW»12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081780100817801008DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÑÄHr¢.DDW¦DˆhHsáhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÑÄHr¢.DDWD¼Hrºè¼DW‘DŠüHsr4|DW¦DˆhHsáhPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081780100817801008.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÑÄHr¢.DDW¦DˆhHsáhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÑÄHr¢.DDWD¼Hrºè¼DW‘DŠüHsr4|DW¦DˆhHsáhPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081780100817801008DW‘DW‘BŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÑÄHr¢.DDW¦DˆhHsáhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÑÄHr¢.DDWD¼Hrºè¼DW‘DŠüHsr4|DW¦DˆhHsáhPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081780100817801008.DWÄBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW#YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÑÄHr¢.DDW¦DˆhHsáhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÑÄHr¢.DDWD¼Hrºè¼DW‘DŠüHsr4|DW¦DˆhHsáhPhase 3A@..DW#.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081781100817811008DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÓhHr¢/èDW¨DŽHsŠPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÓhHr¢/èDWD©8Hr½µ8DW”D‘ÈHsv/ÈDW¨DŽHsŠPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081781100817811008.DW)B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÓhHr¢/èDW¨DŽHsŠPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÓhHr¢/èDWD©8Hr½µ8DW”D‘ÈHsv/ÈDW¨DŽHsŠPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081781100817811008DW”DW”B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÓhHr¢/èDW¨DŽHsŠPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÓhHr¢/èDWD©8Hr½µ8DW”D‘ÈHsv/ÈDW¨DŽHsŠPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081781100817811008.DWÄBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW)YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÓhHr¢/èDW¨DŽHsŠPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÓhHr¢/èDWD©8Hr½µ8DW”D‘ÈHsv/ÈDW¨DŽHsŠPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081785100817851008DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¸.DW% AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÍŒHr£{ŒDWD”\Hr¼NÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÍŒHr£{ŒDWD”\Hr¼NÜ......Phase 3A@..DW%DW¸12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081785100817851008.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¸.DW% AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÍŒHr£{ŒDWD”\Hr¼NÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÍŒHr£{ŒDWD”\Hr¼NÜ......Phase 3A@..DW%DW¸12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081788100817881008DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW( AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DœHr§3DW¢DÑLHsˆäLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DœHr§3DWD£ HrÂõ DWDœTHslÿÔDW¢DÑLHsˆäLPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1008 10081788100817881008.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW( AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DœHr§3DW¢DÑLHsˆäLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DœHr§3DWD£ HrÂõ DWDœTHslÿÔDW¢DÑLHsˆäLPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1008 10081788100817881008DWDWB—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW( AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DœHr§3DW¢DÑLHsˆäLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DœHr§3DWD£ HrÂõ DWDœTHslÿÔDW¢DÑLHsˆäLPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081788100817881008.DW¾BÈOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW(YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DœHr§3DW¢DÑLHsˆäLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DœHr§3DWD£ HrÂõ DWDœTHslÿÔDW¢DÑLHsˆäLPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081789100817891008DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÅ.DW+ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D’Hr§4„DWD¸8HrÃ 8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D’Hr§4„DWD¸8HrÃ 8......Phase 3A@..DW+DWÅ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081789100817891008.DW+B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÅ.DW+ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D’Hr§4„DWD¸8HrÃ 8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D’Hr§4„DWD¸8HrÃ 8......Phase 3A@..DW+DWÅ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081790100817901008DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DW¾DW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÊHr§lˆDW¢DºHsˆÍPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÊHr§lˆDWD¥xHrÂ÷xDWD`HsläàDW¢DºHsˆÍPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081790100817901008.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW¾DW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÊHr§lˆDW¢DºHsˆÍPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÊHr§lˆDWD¥xHrÂ÷xDWD`HsläàDW¢DºHsˆÍPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081790100817901008DWDWB—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW¾DW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÊHr§lˆDW¢DºHsˆÍPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÊHr§lˆDWD¥xHrÂ÷xDWD`HsläàDW¢DºHsˆÍPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081790100817901008.DW¾BÈOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW¾DW)YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÊHr§lˆDW¢DºHsˆÍPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÊHr§lˆDWD¥xHrÂ÷xDWD`HsläàDW¢DºHsˆÍPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081791100817911008DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¿.DW( AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÕ„Hr§xDWD³ˆHrÃˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÕ„Hr§xDWD³ˆHrÃˆ......Phase 3A@..DW(DW¿12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081791100817911008.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¿.DW( AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÕ„Hr§xDWD³ˆHrÃˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÕ„Hr§xDWD³ˆHrÃˆ......Phase 3A@..DW(DW¿12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081792100817921008DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¿.DW( AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÖtHr§xôDWD³HrÃBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÖtHr§xôDWD³HrÃ......Phase 3A@..DW(DW¿12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081792100817921008.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¿.DW( AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÖtHr§xôDWD³HrÃBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÖtHr§xôDWD³HrÃ......Phase 3A@..DW(DW¿12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081793100817931008DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D×ÜHr§z\DW¢DÆÀHsˆÙÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D×ÜHr§z\DWD³LHrÃLDWDÆ„Hsm*DW¢DÆÀHsˆÙÀPhase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081793100817931008.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D×ÜHr§z\DW¢DÆÀHsˆÙÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D×ÜHr§z\DWD³LHrÃLDWDÆ„Hsm*DW¢DÆÀHsˆÙÀPhase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081793100817931008DWDWB—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D×ÜHr§z\DW¢DÆÀHsˆÙÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D×ÜHr§z\DWD³LHrÃLDWDÆ„Hsm*DW¢DÆÀHsˆÙÀPhase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081793100817931008.DW¾BÈOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW(YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D×ÜHr§z\DW¢DÆÀHsˆÙÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D×ÜHr§z\DWD³LHrÃLDWDÆ„Hsm*DW¢DÆÀHsˆÙÀPhase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081794100817941008DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW( AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DV÷DÙHr§{ˆDW¢DÆüHsˆÙüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÙHr§{ˆDWD²˜HrÃ˜DWDÍŒHsm1DW¢DÆüHsˆÙüPhase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081794100817941008.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW( AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DV÷DÙHr§{ˆDW¢DÆüHsˆÙüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÙHr§{ˆDWD²˜HrÃ˜DWDÍŒHsm1DW¢DÆüHsˆÙüPhase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081794100817941008DWDWB—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW( AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DV÷DÙHr§{ˆDW¢DÆüHsˆÙüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÙHr§{ˆDWD²˜HrÃ˜DWDÍŒHsm1DW¢DÆüHsˆÙüPhase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081794100817941008.DW¾BÈOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¾DW(YAÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DV÷DÙHr§{ˆDW¢DÆüHsˆÙüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÙHr§{ˆDWD²˜HrÃ˜DWDÍŒHsm1DW¢DÆüHsˆÙüPhase 3A@..DW(.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081795100817951008DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÃ.DW+ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD¤LHr¨˜LDWD¯HrÆõ”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD¤LHr¨˜LDWD¯HrÆõ”......Phase 3A@..DW+DWÃ12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081795100817951008.DW+B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÃ.DW+ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD¤LHr¨˜LDWD¯HrÆõ”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD¤LHr¨˜LDWD¯HrÆõ”......Phase 3A@..DW+DWÃ12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081796100817961008DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW) AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÆ„Hr¨º„DW¢D Hsˆ³Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWŽDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÆ„Hr¨º„DW DÒHrÄu€DWŽDŽDHsnCDDW¢D Hsˆ³Phase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081796100817961008.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW) AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÆ„Hr¨º„DW¢D Hsˆ³Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWŽDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÆ„Hr¨º„DW DÒHrÄu€DWŽDŽDHsnCDDW¢D Hsˆ³Phase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081796100817961008DWŽDWŽB—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW) AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÆ„Hr¨º„DW¢D Hsˆ³Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWŽDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÆ„Hr¨º„DW DÒHrÄu€DWŽDŽDHsnCDDW¢D Hsˆ³Phase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081796100817961008.DWÃBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW)YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÆ„Hr¨º„DW¢D Hsˆ³Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWŽDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÆ„Hr¨º„DW DÒHrÄu€DWŽDŽDHsnCDDW¢D Hsˆ³Phase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081797100817971008DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÃ.DW* AàYEARSFA AMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÔÐHr¨ÈÐDW DÛ`HrÄ~àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÔÐHr¨ÈÐDW DÛ`HrÄ~à......Phase 3A@..DW*DWÃ12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081797100817971008.DW*B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÃ.DW* AàYEARSFA AMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÔÐHr¨ÈÐDW DÛ`HrÄ~àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÔÐHr¨ÈÐDW DÛ`HrÄ~à......Phase 3A@..DW*DWÃ12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081798100817981008DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DW¿DW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÖ°Hr¨Ê°DW£DÅXHsŠ)ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖ°Hr¨Ê°DW DÚ4HrÄ}´DWŽD4Hsnb4DW£DÅXHsŠ)ØPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081798100817981008.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW¿DW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÖ°Hr¨Ê°DW£DÅXHsŠ)ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖ°Hr¨Ê°DW DÚ4HrÄ}´DWŽD4Hsnb4DW£DÅXHsŠ)ØPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081798100817981008DWŽDWŽB—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW¿DW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÖ°Hr¨Ê°DW£DÅXHsŠ)ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖ°Hr¨Ê°DW DÚ4HrÄ}´DWŽD4Hsnb4DW£DÅXHsŠ)ØPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081798100817981008.DW¿BÈOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW¿DW)YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÖ°Hr¨Ê°DW£DÅXHsŠ)ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖ°Hr¨Ê°DW DÚ4HrÄ}´DWŽD4Hsnb4DW£DÅXHsŠ)ØPhase 3A@..DW).12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081799100817991008DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÉ.DW) AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD×ÜHr¨ËÜDW D‘ÈHrÄ5HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD×ÜHr¨ËÜDW D‘ÈHrÄ5H......Phase 3A@..DW)DWÉ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081799100817991008.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÉ.DW) AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD×ÜHr¨ËÜDW D‘ÈHrÄ5HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD×ÜHr¨ËÜDW D‘ÈHrÄ5H......Phase 3A@..DW)DWÉ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081800100818001008DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÄ.DW* AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDŸ`Hr©äàDWD»DHrÅ°DBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDŸ`Hr©äàDWD»DHrÅ°D......Phase 3A@..DW*DWÄ12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081800100818001008.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÄ.DW* AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDŸ`Hr©äàDWD»DHrÅ°DBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDŸ`Hr©äàDWD»DHrÅ°D......Phase 3A@..DW*DWÄ12-15 YearsAYYNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081801100818011008DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD›(Hr«2(DW¦DÀlHsŽlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD›(Hr«2(DWDHrÈDW‘DÄàHsrn`DW¦DÀlHsŽlPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081801100818011008.DW,B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD›(Hr«2(DW¦DÀlHsŽlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD›(Hr«2(DWDHrÈDW‘DÄàHsrn`DW¦DÀlHsŽlPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081801100818011008DW‘DW‘B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD›(Hr«2(DW¦DÀlHsŽlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD›(Hr«2(DWDHrÈDW‘DÄàHsrn`DW¦DÀlHsŽlPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081801100818011008.DWÃBÊOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW,YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD›(Hr«2(DW¦DÀlHsŽlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD›(Hr«2(DWDHrÈDW‘DÄàHsrn`DW¦DÀlHsŽlPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081802100818021008DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÅÐHr«\ÐDWDˆhHrÆÎèBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÅÐHr«\ÐDWDˆhHrÆÎè......Phase 3A@..DW+DW¾12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081802100818021008.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÅÐHr«\ÐDWDˆhHrÆÎèBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÅÐHr«\ÐDWDˆhHrÆÎè......Phase 3A@..DW+DW¾12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081803100818031008DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW‹DW+ AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÇìHr«^ìDWkDÃxHs@SøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWVDWk.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÇìHr«^ìDWD¥´HrÆì4DWVDÅ”Hs$¦”DWkDÃxHs@SøPhase 3A@..DW+.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSAC4591001C4591001 1008 10081803100818031008.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW‹DW+ AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÇìHr«^ìDWkDÃxHs@SøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWVDWk.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÇìHr«^ìDWD¥´HrÆì4DWVDÅ”Hs$¦”DWkDÃxHs@SøPhase 3A@..DW+.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA C4591001C4591001 1008 10081803100818031008DWVDWVB]REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW‹DW+ AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÇìHr«^ìDWkDÃxHs@SøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWVDWk.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÇìHr«^ìDWD¥´HrÆì4DWVDÅ”Hs$¦”DWkDÃxHs@SøPhase 3A@..DW+.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA0C4591001C4591001 1008 10081803100818031008.DW‹B’OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW‹DW+YAðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÇìHr«^ìDWkDÃxHs@SøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWVDWk.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÇìHr«^ìDWD¥´HrÆì4DWVDÅ”Hs$¦”DWkDÃxHs@SøPhase 3A@..DW+.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA@C4591001C4591001 1008 10081804100818041008DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¾DW2 AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDÎ¸Hr«e¸DW¢DÈÜHsˆÛÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÎ¸Hr«e¸DWDØHrÇDWDÎ@Hsm1ÀDW¢DÈÜHsˆÛÜPhase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081804100818041008.DW2B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¾DW2 AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDÎ¸Hr«e¸DW¢DÈÜHsˆÛÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÎ¸Hr«e¸DWDØHrÇDWDÎ@Hsm1ÀDW¢DÈÜHsˆÛÜPhase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081804100818041008DWDWB”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¾DW2 AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDÎ¸Hr«e¸DW¢DÈÜHsˆÛÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÎ¸Hr«e¸DWDØHrÇDWDÎ@Hsm1ÀDW¢DÈÜHsˆÛÜPhase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081804100818041008.DW¾BÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¾DW2YAàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDÎ¸Hr«e¸DW¢DÈÜHsˆÛÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÎ¸Hr«e¸DWDØHrÇDWDÎ@Hsm1ÀDW¢DÈÜHsˆÛÜPhase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081805100818051008DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÚ¬Hr«q¬DWDÚpHrÇ ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÚ¬Hr«q¬DWDÚpHrÇ ð......Phase 3A@..DW,.12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081805100818051008.DW,B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÚ¬Hr«q¬DWDÚpHrÇ ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÚ¬Hr«q¬DWDÚpHrÇ ð......Phase 3A@..DW,.12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081806100818061008DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÆ.DW+ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÝ|Hr«t|DWDÔHrÇœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÝ|Hr«t|DWDÔHrÇœ......Phase 3A@..DW+DWÆ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081806100818061008.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÆ.DW+ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÝ|Hr«t|DWDÔHrÇœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÝ|Hr«t|DWDÔHrÇœ......Phase 3A@..DW+DWÆ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081807100818071008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD’|Hr¬züDW£D‡´Hs‰ì4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD’|Hr¬züDWD§”HrÈ?”DWŽDŽøHsnCøDW£D‡´Hs‰ì4Phase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081807100818071008.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD’|Hr¬züDW£D‡´Hs‰ì4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD’|Hr¬züDWD§”HrÈ?”DWŽDŽøHsnCøDW£D‡´Hs‰ì4Phase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081807100818071008DWŽDWŽB”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD’|Hr¬züDW£D‡´Hs‰ì4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD’|Hr¬züDWD§”HrÈ?”DWŽDŽøHsnCøDW£D‡´Hs‰ì4Phase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081807100818071008.DWÃBÉOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW,YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD’|Hr¬züDW£D‡´Hs‰ì4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD’|Hr¬züDWD§”HrÈ?”DWŽDŽøHsnCøDW£D‡´Hs‰ì4Phase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081808100818081008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÃDW3 AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûD–Hr¬~€DW¦D‰ÐHsâÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD–Hr¬~€DWD¦¤HrÈ>¤DW‘D‰”Hsr3DW¦D‰ÐHsâÐPhase 3A@..DW3.12-15 YearsAYYNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081808100818081008.DW3B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÃDW3 AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûD–Hr¬~€DW¦D‰ÐHsâÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD–Hr¬~€DWD¦¤HrÈ>¤DW‘D‰”Hsr3DW¦D‰ÐHsâÐPhase 3A@..DW3.12-15 YearsAYYNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081808100818081008DW‘DW‘B—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÃDW3 AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûD–Hr¬~€DW¦D‰ÐHsâÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD–Hr¬~€DWD¦¤HrÈ>¤DW‘D‰”Hsr3DW¦D‰ÐHsâÐPhase 3A@..DW3.12-15 YearsAYYNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081808100818081008.DWÃBÉOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÃDW3YAÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûD–Hr¬~€DW¦D‰ÐHsâÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD–Hr¬~€DWD¦¤HrÈ>¤DW‘D‰”Hsr3DW¦D‰ÐHsâÐPhase 3A@..DW3.12-15 YearsAYYNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081809100818091008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWËDW0 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûD£ Hr¬‹ DW¢DªÜHsˆ½ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD£ Hr¬‹ DWD±0HrÈI0DWDì@HsmOÀDW¢DªÜHsˆ½ÜPhase 3A@..DW0.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081809100818091008.DW0B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWËDW0 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûD£ Hr¬‹ DW¢DªÜHsˆ½ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD£ Hr¬‹ DWD±0HrÈI0DWDì@HsmOÀDW¢DªÜHsˆ½ÜPhase 3A@..DW0.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081809100818091008DWDWB“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWËDW0 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûD£ Hr¬‹ DW¢DªÜHsˆ½ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD£ Hr¬‹ DWD±0HrÈI0DWDì@HsmOÀDW¢DªÜHsˆ½ÜPhase 3A@..DW0.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081809100818091008.DWËBÑOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWËDW0YAÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûD£ Hr¬‹ DW¢DªÜHsˆ½ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD£ Hr¬‹ DWD±0HrÈI0DWDì@HsmOÀDW¢DªÜHsˆ½ÜPhase 3A@..DW0.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081810100818101008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD§ÐHr¬PDWDŸ$HrÈ7$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD§ÐHr¬PDWDŸ$HrÈ7$......Phase 3A@..DW,DW¿12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081810100818101008.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD§ÐHr¬PDWDŸ$HrÈ7$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD§ÐHr¬PDWDŸ$HrÈ7$......Phase 3A@..DW,DW¿12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081811100818111008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD¦,Hr¬Ž¬DWDžpHrÈ6pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD¦,Hr¬Ž¬DWDžpHrÈ6p......Phase 3A@..DW,DW¿12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081811100818111008.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD¦,Hr¬Ž¬DWDžpHrÈ6pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD¦,Hr¬Ž¬DWDžpHrÈ6p......Phase 3A@..DW,DW¿12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081812100818121008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW¿DW1 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÉHr¬²DW£Dˆ¤Hs‰í$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÉHr¬²DWDÎôHrÈfôDWDåtHsmHôDW£Dˆ¤Hs‰í$Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081812100818121008.DW1B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW¿DW1 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÉHr¬²DW£Dˆ¤Hs‰í$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÉHr¬²DWDÎôHrÈfôDWDåtHsmHôDW£Dˆ¤Hs‰í$Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081812100818121008DWDWB“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW¿DW1 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÉHr¬²DW£Dˆ¤Hs‰í$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÉHr¬²DWDÎôHrÈfôDWDåtHsmHôDW£Dˆ¤Hs‰í$Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081812100818121008.DW¿BÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW¿DW1YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÉHr¬²DW£Dˆ¤Hs‰í$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÉHr¬²DWDÎôHrÈfôDWDåtHsmHôDW£Dˆ¤Hs‰í$Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081813100818131008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÉ.DW/ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÎ¸Hr¬·8DWD¥<HrÈ=<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÎ¸Hr¬·8DWD¥<HrÈ=<......Phase 3A@..DW/DWÉ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081813100818131008.DW/B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÉ.DW/ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÎ¸Hr¬·8DWD¥<HrÈ=<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÎ¸Hr¬·8DWD¥<HrÈ=<......Phase 3A@..DW/DWÉ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081814100818141008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÕÀHr¬¾@DWDÕÀHrÈmÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÕÀHr¬¾@DWDÕÀHrÈmÀ......Phase 3A@..DW,DW¿12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081814100818141008.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÕÀHr¬¾@DWDÕÀHrÈmÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÕÀHr¬¾@DWDÕÀHrÈmÀ......Phase 3A@..DW,DW¿12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081815100818151008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVûDØHr¬À˜DW©D„äHs‘ÒdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDØHr¬À˜DWDÐ˜HrÈh˜DW”D¿¸Hsv]¸DW©D„äHs‘ÒdPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1008 10081815100818151008.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVûDØHr¬À˜DW©D„äHs‘ÒdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDØHr¬À˜DWDÐ˜HrÈh˜DW”D¿¸Hsv]¸DW©D„äHs‘ÒdPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1008 10081815100818151008DW”DW”BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVûDØHr¬À˜DW©D„äHs‘ÒdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDØHr¬À˜DWDÐ˜HrÈh˜DW”D¿¸Hsv]¸DW©D„äHs‘ÒdPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081815100818151008.DWÅBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW,YAÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVûDØHr¬À˜DW©D„äHs‘ÒdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDØHr¬À˜DWDÐ˜HrÈh˜DW”D¿¸Hsv]¸DW©D„äHs‘ÒdPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081816100818161008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD×dHr¬¿äDWDÑHrÈiBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD×dHr¬¿äDWDÑHrÈi......Phase 3A@..DW,DW¿12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081816100818161008.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD×dHr¬¿äDWDÑHrÈiBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD×dHr¬¿äDWDÑHrÈi......Phase 3A@..DW,DW¿12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081817100818171008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3.DW¿DW3 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûDÜÈHr¬ÅHDW£D¨HHsŠÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÜÈHr¬ÅHDWD× HrÅÌ DWŽD±äHsnfäDW£D¨HHsŠÈPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081817100818171008.DW3B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DW¿DW3 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûDÜÈHr¬ÅHDW£D¨HHsŠÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÜÈHr¬ÅHDWD× HrÅÌ DWŽD±äHsnfäDW£D¨HHsŠÈPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081817100818171008DWŽDWŽB”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DW¿DW3 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûDÜÈHr¬ÅHDW£D¨HHsŠÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÜÈHr¬ÅHDWD× HrÅÌ DWŽD±äHsnfäDW£D¨HHsŠÈPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081817100818171008.DW¿BÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DW¿DW3YAÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVûDÜÈHr¬ÅHDW£D¨HHsŠÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÜÈHr¬ÅHDWD× HrÅÌ DWŽD±äHsnfäDW£D¨HHsŠÈPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081818100818181008DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÅ.DW, AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÞ¨Hr¬Ç(DWDËpHrÈcpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÞ¨Hr¬Ç(DWDËpHrÈcp......Phase 3A@..DW,DWÅ12-15 YearsAYYNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081818100818181008.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÅ.DW, AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÞ¨Hr¬Ç(DWDËpHrÈcpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÞ¨Hr¬Ç(DWDËpHrÈcp......Phase 3A@..DW,DWÅ12-15 YearsAYYNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081819100818191008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDpHr°lpDW§D… Hs/ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDpHr°lpDWDÓ,HrÌ_¬DW’D€èHss{èDW§D… Hs/ Phase 3A@..DW/.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081819100818191008.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDpHr°lpDW§D… Hs/ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDpHr°lpDWDÓ,HrÌ_¬DW’D€èHss{èDW§D… Hs/ Phase 3A@..DW/.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081819100818191008DW’DW’B•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDpHr°lpDW§D… Hs/ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDpHr°lpDWDÓ,HrÌ_¬DW’D€èHss{èDW§D… Hs/ Phase 3A@..DW/.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081819100818191008.DWÃBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDpHr°lpDW§D… Hs/ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDpHr°lpDWDÓ,HrÌ_¬DW’D€èHss{èDW§D… Hs/ Phase 3A@..DW/.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081820100818201008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÊDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDØHr°mØDW®DºÌHs˜ŸÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDØHr°mØDWD»€HrÌHDW™DÀ0Hs|õ°DW®DºÌHs˜ŸÌPhase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081820100818201008.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÊDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDØHr°mØDW®DºÌHs˜ŸÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDØHr°mØDWD»€HrÌHDW™DÀ0Hs|õ°DW®DºÌHs˜ŸÌPhase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081820100818201008DW™DW™BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÊDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDØHr°mØDW®DºÌHs˜ŸÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDØHr°mØDWD»€HrÌHDW™DÀ0Hs|õ°DW®DºÌHs˜ŸÌPhase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081820100818201008.DWÊBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÊDW1YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDØHr°mØDW®DºÌHs˜ŸÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDØHr°mØDWD»€HrÌHDW™DÀ0Hs|õ°DW®DºÌHs˜ŸÌPhase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081821100818211008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÆ.DW/ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD˜Hr°uDWDÓ¤HrÍ±¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD˜Hr°uDWDÓ¤HrÍ±¤......Phase 3A@..DW/DWÆ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081821100818211008.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÆ.DW/ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD˜Hr°uDWDÓ¤HrÍ±¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD˜Hr°uDWDÓ¤HrÍ±¤......Phase 3A@..DW/DWÆ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081822100818221008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÃDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD›ÜHr°xÜDW£D4Hs‰ó´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD›ÜHr°xÜDWDÕüHrÌb|DWŽD®ØHsncØDW£D4Hs‰ó´Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081822100818221008.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÃDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD›ÜHr°xÜDW£D4Hs‰ó´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD›ÜHr°xÜDWDÕüHrÌb|DWŽD®ØHsncØDW£D4Hs‰ó´Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081822100818221008DWŽDWŽB‘REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÃDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD›ÜHr°xÜDW£D4Hs‰ó´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD›ÜHr°xÜDWDÕüHrÌb|DWŽD®ØHsncØDW£D4Hs‰ó´Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081822100818221008.DWÃBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÃDW1YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD›ÜHr°xÜDW£D4Hs‰ó´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD›ÜHr°xÜDWDÕüHrÌb|DWŽD®ØHsncØDW£D4Hs‰ó´Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081823100818231008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÃ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDHr°zDWD}dHrÌ äBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDHr°zDWD}dHrÌ ä......Phase 3A@..DW6DWÃ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081823100818231008.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÃ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDHr°zDWD}dHrÌ äBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDHr°zDWD}dHrÌ ä......Phase 3A@..DW6DWÃ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081824100818241008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÍ.DW3 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¥<Hr°‚<DWD‡HrÌ€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¥<Hr°‚<DWD‡HrÌ€......Phase 3A@..DW3DWÍ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081824100818241008.DW3B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÍ.DW3 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¥<Hr°‚<DWD‡HrÌ€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¥<Hr°‚<DWD‡HrÌ€......Phase 3A@..DW3DWÍ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081825100818251008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¾DW2 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÆ„Hr°£„DW¢Dž4Hsˆ±4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÆ„Hr°£„DWDÀäHrÌMdDWDÃxHsm&øDW¢Dž4Hsˆ±4Phase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081825100818251008.DW2B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¾DW2 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÆ„Hr°£„DW¢Dž4Hsˆ±4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÆ„Hr°£„DWDÀäHrÌMdDWDÃxHsm&øDW¢Dž4Hsˆ±4Phase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081825100818251008DWDWBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¾DW2 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÆ„Hr°£„DW¢Dž4Hsˆ±4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÆ„Hr°£„DWDÀäHrÌMdDWDÃxHsm&øDW¢Dž4Hsˆ±4Phase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081825100818251008.DW¾BÁOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¾DW2YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÆ„Hr°£„DW¢Dž4Hsˆ±4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÆ„Hr°£„DWDÀäHrÌMdDWDÃxHsm&øDW¢Dž4Hsˆ±4Phase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081826100818261008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÅ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÇìHr°¤ìDWD¿|HrÍ|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÇìHr°¤ìDWD¿|HrÍ|......Phase 3A@..DW6DWÅ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081826100818261008.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÅ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÇìHr°¤ìDWD¿|HrÍ|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÇìHr°¤ìDWD¿|HrÍ|......Phase 3A@..DW6DWÅ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081827100818271008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÄ.DW3 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÔ”Hr°±”DWDÑHrÌ]BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÔ”Hr°±”DWDÑHrÌ]......Phase 3A@..DW3DWÄ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081827100818271008.DW3B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÄ.DW3 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÔ”Hr°±”DWDÑHrÌ]BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÔ”Hr°±”DWDÑHrÌ]......Phase 3A@..DW3DWÄ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081828100818281008DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÒHr°¯DW§DÄ,Hsn¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÒHr°¯DWDÏlHrÚÜlDWŽD£\HsnX\DW§DÄ,Hsn¬Phase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081828100818281008.DW@BCVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÒHr°¯DW§DÄ,Hsn¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÒHr°¯DWDÏlHrÚÜlDWŽD£\HsnX\DW§DÄ,Hsn¬Phase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081828100818281008DWŽDWŽB‘REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÒHr°¯DW§DÄ,Hsn¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÒHr°¯DWDÏlHrÚÜlDWŽD£\HsnX\DW§DÄ,Hsn¬Phase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081828100818281008.DWÄBÇOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÒHr°¯DW§DÄ,Hsn¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÒHr°¯DWDÏlHrÚÜlDWŽD£\HsnX\DW§DÄ,Hsn¬Phase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081829100818291008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0..DW0 AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVÿD‹°Hr±º0DWDÕHrÍ³Placebo Placebo 12-15 YearsA . . .DVÿDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVÿD‹°Hr±º0DWDÕHrÍ³......Phase 3A@DW.DW0.12-15 YearsA YNN. DW‹DWDWAÐYEARSDSAC4591001C4591001 1008 10081829100818291008.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0..DW0 AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVÿD‹°Hr±º0DWDÕHrÍ³Placebo Placebo 12-15 YearsA . . .DVÿDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVÿD‹°Hr±º0DWDÕHrÍ³......Phase 3A@DW.DW0.12-15 YearsA YNN. DW‹DWDWAÐYEARSDSA C4591001C4591001 1008 10081829100818291008.DWBFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN Brequested unblinding 5/12, withdrew consent 5/13 DW0..DW0YAÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVÿD‹°Hr±º0DWDÕHrÍ³Placebo Placebo 12-15 YearsA . . .DVÿDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVÿD‹°Hr±º0DWDÕHrÍ³......Phase 3A@DW.DW0.12-15 YearsA YNN. DW‹DWDWAÐYEARSDSA`C4591001C4591001 1008 10081830100818301008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDHr±»˜DW¨D¡HsPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDHr±»˜DWDÍPHrÎüÐDW“DÃðHsupDW¨D¡HsPhase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081830100818301008.DW1B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDHr±»˜DW¨D¡HsPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDHr±»˜DWDÍPHrÎüÐDW“DÃðHsupDW¨D¡HsPhase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081830100818301008DW“DW“B•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDHr±»˜DW¨D¡HsPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDHr±»˜DWDÍPHrÎüÐDW“DÃðHsupDW¨D¡HsPhase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081830100818301008.DWÄBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDHr±»˜DW¨D¡HsPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDHr±»˜DWDÍPHrÎüÐDW“DÃðHsupDW¨D¡HsPhase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081831100818311008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÃ.DW6 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD—hHr±ÅèDWD{ÀHrÍYÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD—hHr±ÅèDWD{ÀHrÍYÀ......Phase 3A@..DW6DWÃ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081831100818311008.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÃ.DW6 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD—hHr±ÅèDWD{ÀHrÍYÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD—hHr±ÅèDWD{ÀHrÍYÀ......Phase 3A@..DW6DWÃ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081832100818321008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DWð.DW0 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDœHr±Ê˜DWD‚ŒHrÍ`ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW‡BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDœHr±Ê˜DWD‚ŒHrÍ`Œ......Phase 3A@..DW0DWð12-15 YearsA YNY. DW†DWýDWýAðYEARSDSAC4591001C4591001 1008 10081832100818321008.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DWð.DW0 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDœHr±Ê˜DWD‚ŒHrÍ`ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW‡BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDœHr±Ê˜DWD‚ŒHrÍ`Œ......Phase 3A@..DW0DWð12-15 YearsA YNY. DW†DWýDWýAðYEARSDSA C4591001C4591001 1008 10081833100818331008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DW¿DW0 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDšìHr±ÉlDW£D$Hs‰ô¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDšìHr±ÉlDWD‚HrÍ`DWŽDºÌHsnoÌDW£D$Hs‰ô¤Phase 3A@..DW0.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081833100818331008.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DW¿DW0 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDšìHr±ÉlDW£D$Hs‰ô¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDšìHr±ÉlDWD‚HrÍ`DWŽDºÌHsnoÌDW£D$Hs‰ô¤Phase 3A@..DW0.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081833100818331008DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DW¿DW0 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDšìHr±ÉlDW£D$Hs‰ô¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDšìHr±ÉlDWD‚HrÍ`DWŽDºÌHsnoÌDW£D$Hs‰ô¤Phase 3A@..DW0.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081833100818331008.DW¿BÁOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DW¿DW0YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDšìHr±ÉlDW£D$Hs‰ô¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDšìHr±ÉlDWD‚HrÍ`DWŽDºÌHsnoÌDW£D$Hs‰ô¤Phase 3A@..DW0.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081834100818341008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD´xHr±âøDWDÑHrÏPlacebo Placebo 12-15 YearsA . . .DVÿDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVÿD´xHr±âøDWDÑHrÏ......Phase 3A@DW.DW1.12-15 YearsA YNN. DW‹DWDWAÐYEARSDSAC4591001C4591001 1008 10081834100818341008.DW1B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD´xHr±âøDWDÑHrÏPlacebo Placebo 12-15 YearsA . . .DVÿDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVÿD´xHr±âøDWDÑHrÏ......Phase 3A@DW.DW1.12-15 YearsA YNN. DW‹DWDWAÐYEARSDSA C4591001C4591001 1008 10081834100818341008.DWBFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN Brequested unblinding 5/12, withdrew consent 5/13 DW1..DW1YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD´xHr±âøDWDÑHrÏPlacebo Placebo 12-15 YearsA . . .DVÿDW....DWŒPlacebo Placebo Placebo A .Placebo A .DVÿD´xHr±âøDWDÑHrÏ......Phase 3A@DW.DW1.12-15 YearsA YNN. DW‹DWDWAÐYEARSDSA`C4591001C4591001 1008 10081835100818351008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÃ.DW0 AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÉHr±÷˜DWDÒxHrÍ°xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÉHr±÷˜DWDÒxHrÍ°x......Phase 3A@..DW0DWÃ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081835100818351008.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÃ.DW0 AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÉHr±÷˜DWDÒxHrÍ°xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÉHr±÷˜DWDÒxHrÍ°x......Phase 3A@..DW0DWÃ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081836100818361008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¿DW2 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÒ´Hr²4DW£D–xHs‰úøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÒ´Hr²4DWD}(HrÍ[(DWŽD–ðHsnKðDW£D–xHs‰úøPhase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081836100818361008.DW2B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¿DW2 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÒ´Hr²4DW£D–xHs‰úøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÒ´Hr²4DWD}(HrÍ[(DWŽD–ðHsnKðDW£D–xHs‰úøPhase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081836100818361008DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¿DW2 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÒ´Hr²4DW£D–xHs‰úøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÒ´Hr²4DWD}(HrÍ[(DWŽD–ðHsnKðDW£D–xHs‰úøPhase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081836100818361008.DW¿BÁOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DW¿DW2YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÒ´Hr²4DW£D–xHs‰úøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÒ´Hr²4DWD}(HrÍ[(DWŽD–ðHsnKðDW£D–xHs‰úøPhase 3A@..DW2.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081837100818371008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÄDW3 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÜPHr² ÐDW¨DÁÔHs½ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÜPHr² ÐDWDÙDHrÍ·DDW“DÅÐHsuPDW¨DÁÔHs½ÔPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081837100818371008.DW3B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÄDW3 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÜPHr² ÐDW¨DÁÔHs½ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÜPHr² ÐDWDÙDHrÍ·DDW“DÅÐHsuPDW¨DÁÔHs½ÔPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081837100818371008DW“DW“B•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÄDW3 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÜPHr² ÐDW¨DÁÔHs½ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÜPHr² ÐDWDÙDHrÍ·DDW“DÅÐHsuPDW¨DÁÔHs½ÔPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081837100818371008.DWÄBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÄDW3YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÜPHr² ÐDW¨DÁÔHs½ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÜPHr² ÐDWDÙDHrÍ·DDW“DÅÐHsuPDW¨DÁÔHs½ÔPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081838100818381008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÝ@Hr²ÀDWDØTHrÍ¶TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÝ@Hr²ÀDWDØTHrÍ¶T......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081838100818381008.DW3B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÝ@Hr²ÀDWDØTHrÍ¶TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÝ@Hr²ÀDWDØTHrÍ¶T......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081839100818391008DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÐ.DW6 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÞ¨Hr² (DWDËpHrÍ©pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÞ¨Hr² (DWDËpHrÍ©p......Phase 3A@..DW6DWÐ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081839100818391008.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÐ.DW6 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÞ¨Hr² (DWDËpHrÍ©pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÞ¨Hr² (DWDËpHrÍ©p......Phase 3A@..DW6DWÐ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081840100818401008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW¿DW1 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHr³ðDW£DÃHsŠ'€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡ðHr³ðDWDÒ´HrÏ4DWŽDÓ¤Hsnˆ¤DW£DÃHsŠ'€Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081840100818401008.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW¿DW1 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHr³ðDW£DÃHsŠ'€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡ðHr³ðDWDÒ´HrÏ4DWŽDÓ¤Hsnˆ¤DW£DÃHsŠ'€Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081840100818401008DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW¿DW1 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHr³ðDW£DÃHsŠ'€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡ðHr³ðDWDÒ´HrÏ4DWŽDÓ¤Hsnˆ¤DW£DÃHsŠ'€Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081840100818401008.DW¿BÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DW¿DW1YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHr³ðDW£DÃHsŠ'€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡ðHr³ðDWDÒ´HrÏ4DWŽDÓ¤Hsnˆ¤DW£DÃHsŠ'€Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081841100818411008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÊ.DW3 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDˆàHr³àDWDÊøHrÎúxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDˆàHr³àDWDÊøHrÎúx......Phase 3A@..DW3DWÊ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081841100818411008.DW3B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÊ.DW3 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDˆàHr³àDWDÊøHrÎúxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDˆàHr³àDWDÊøHrÎúx......Phase 3A@..DW3DWÊ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081842100818421008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÅDW: AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‰ÐHr³ ÐDW¨D¿ôHs»ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‰ÐHr³ ÐDWDy¤HrÍW¤DW“D¹ Hsu DW¨D¿ôHs»ôPhase 3A@..DW:.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081842100818421008.DW:B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÅDW: AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‰ÐHr³ ÐDW¨D¿ôHs»ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‰ÐHr³ ÐDWDy¤HrÍW¤DW“D¹ Hsu DW¨D¿ôHs»ôPhase 3A@..DW:.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081842100818421008DW“DW“B”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÅDW: AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‰ÐHr³ ÐDW¨D¿ôHs»ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‰ÐHr³ ÐDWDy¤HrÍW¤DW“D¹ Hsu DW¨D¿ôHs»ôPhase 3A@..DW:.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081842100818421008.DWÅBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÅDW:YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‰ÐHr³ ÐDW¨D¿ôHs»ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‰ÐHr³ ÐDWDy¤HrÍW¤DW“D¹ Hsu DW¨D¿ôHs»ôPhase 3A@..DW:.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081843100818431008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÄ.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŽ¼Hr³¼DWDÓ¤HrÏ$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŽ¼Hr³¼DWDÓ¤HrÏ$......Phase 3A@..DW1DWÄ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081843100818431008.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÄ.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŽ¼Hr³¼DWDÓ¤HrÏ$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŽ¼Hr³¼DWDÓ¤HrÏ$......Phase 3A@..DW1DWÄ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081844100818441008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÅDW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr³¬DW¨D×(HsÓ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr³¬DWDÓàHrÏ`DW“DŽDHstÚÄDW¨D×(HsÓ(Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081844100818441008.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÅDW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr³¬DW¨D×(HsÓ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr³¬DWDÓàHrÏ`DW“DŽDHstÚÄDW¨D×(HsÓ(Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081844100818441008DW“DW“B”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÅDW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr³¬DW¨D×(HsÓ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr³¬DWDÓàHrÏ`DW“DŽDHstÚÄDW¨D×(HsÓ(Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081844100818441008.DWÅBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÅDW1YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr³¬DW¨D×(HsÓ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr³¬DWDÓàHrÏ`DW“DŽDHstÚÄDW¨D×(HsÓ(Phase 3A@..DW1.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081845100818451008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÅDW3 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDž4Hr³4DW§D‰Hs3œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDž4Hr³4DWDƒ|HrÌüDW‘DÅXHsrnØDW§D‰Hs3œPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081845100818451008.DW3B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÅDW3 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDž4Hr³4DW§D‰Hs3œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDž4Hr³4DWDƒ|HrÌüDW‘DÅXHsrnØDW§D‰Hs3œPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081845100818451008DW‘DW‘B’REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÅDW3 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDž4Hr³4DW§D‰Hs3œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDž4Hr³4DWDƒ|HrÌüDW‘DÅXHsrnØDW§D‰Hs3œPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081845100818451008.DWÅBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÅDW3YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDž4Hr³4DW§D‰Hs3œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDž4Hr³4DWDƒ|HrÌüDW‘DÅXHsrnØDW§D‰Hs3œPhase 3A@..DW3.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081846100818461008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD PHr³ PDWD‚ÈHrÌHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD PHr³ PDWD‚ÈHrÌH......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081846100818461008.DW3B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD PHr³ PDWD‚ÈHrÌHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD PHr³ PDWD‚ÈHrÌH......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081847100818471008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœÌHr³ÌDWDÂÄHrÎòDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœÌHr³ÌDWDÂÄHrÎòD......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081847100818471008.DW3B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœÌHr³ÌDWDÂÄHrÎòDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœÌHr³ÌDWDÂÄHrÎòD......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081848100818481008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÆ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡ôHr³!ôDWDÔÐHrÐUÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡ôHr³!ôDWDÔÐHrÐUÐ......Phase 3A@..DW3DWÆ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081848100818481008.DW3B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÆ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡ôHr³!ôDWDÔÐHrÐUÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡ôHr³!ôDWDÔÐHrÐUÐ......Phase 3A@..DW3DWÆ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081849100818491008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DW¿DW9 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£\Hr³#\DW£D¨HsŠŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£\Hr³#\DWD´xHrÐ5xDWŽDÅ”Hsnz”DW£D¨HsŠŒPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081849100818491008.DW9B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DW¿DW9 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£\Hr³#\DW£D¨HsŠŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£\Hr³#\DWD´xHrÐ5xDWŽDÅ”Hsnz”DW£D¨HsŠŒPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081849100818491008DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DW¿DW9 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£\Hr³#\DW£D¨HsŠŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£\Hr³#\DWD´xHrÐ5xDWŽDÅ”Hsnz”DW£D¨HsŠŒPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081849100818491008.DW¿BÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DW¿DW9YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£\Hr³#\DW£D¨HsŠŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£\Hr³#\DWD´xHrÐ5xDWŽDÅ”Hsnz”DW£D¨HsŠŒPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081850100818501008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÉ.DW7 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¨HHr³(HDWDÈÜHrÐIÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWVBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¨HHr³(HDWDÈÜHrÐIÜ......Phase 3A@..DW7DWÉ12-15 YearsA YNY. DWUDWýDWýAðYEARSDSAC4591001C4591001 1008 10081850100818501008.DW7B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÉ.DW7 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¨HHr³(HDWDÈÜHrÐIÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWVBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¨HHr³(HDWDÈÜHrÐIÜ......Phase 3A@..DW7DWÉ12-15 YearsA YNY. DWUDWýDWýAðYEARSDSA C4591001C4591001 1008 10081851100818511008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD²ÔHr³2ÔDW§D‚ÈHs-HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD²ÔHr³2ÔDWD¹ HrÑŒ DW’D€4Hss{4DW§D‚ÈHs-HPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081851100818511008.DW9B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD²ÔHr³2ÔDW§D‚ÈHs-HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD²ÔHr³2ÔDWD¹ HrÑŒ DW’D€4Hss{4DW§D‚ÈHs-HPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081851100818511008DW’DW’B“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD²ÔHr³2ÔDW§D‚ÈHs-HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD²ÔHr³2ÔDWD¹ HrÑŒ DW’D€4Hss{4DW§D‚ÈHs-HPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081851100818511008.DWÃBÄOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD²ÔHr³2ÔDW§D‚ÈHs-HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD²ÔHr³2ÔDWD¹ HrÑŒ DW’D€4Hss{4DW§D‚ÈHs-HPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081852100818521008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD³ÄHr³3ÄDW§Dƒ@Hs-ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD³ÄHr³3ÄDWDºÌHrÑLDW’D€¬Hss{¬DW§Dƒ@Hs-ÀPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081852100818521008.DW9B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD³ÄHr³3ÄDW§Dƒ@Hs-ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD³ÄHr³3ÄDWDºÌHrÑLDW’D€¬Hss{¬DW§Dƒ@Hs-ÀPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081852100818521008DW’DW’B“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD³ÄHr³3ÄDW§Dƒ@Hs-ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD³ÄHr³3ÄDWDºÌHrÑLDW’D€¬Hss{¬DW§Dƒ@Hs-ÀPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081852100818521008.DWÃBÄOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD³ÄHr³3ÄDW§Dƒ@Hs-ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD³ÄHr³3ÄDWDºÌHrÑLDW’D€¬Hss{¬DW§Dƒ@Hs-ÀPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081853100818531008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÃDW6 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDØHr¹¨XDW¦DÁ HsŽ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDØHr¹¨XDWD‡ðHrÕNðDW‘DÄhHsrmèDW¦DÁ HsŽ Phase 3A@..DW6.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081853100818531008.DW6B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÃDW6 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDØHr¹¨XDW¦DÁ HsŽ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDØHr¹¨XDWD‡ðHrÕNðDW‘DÄhHsrmèDW¦DÁ HsŽ Phase 3A@..DW6.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081853100818531008DW‘DW‘BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÃDW6 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDØHr¹¨XDW¦DÁ HsŽ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDØHr¹¨XDWD‡ðHrÕNðDW‘DÄhHsrmèDW¦DÁ HsŽ Phase 3A@..DW6.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081853100818531008.DWÃB¿OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÃDW6YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDØHr¹¨XDW¦DÁ HsŽ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDØHr¹¨XDWD‡ðHrÕNðDW‘DÄhHsrmèDW¦DÁ HsŽ Phase 3A@..DW6.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081854100818541008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÆ.DW6 AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD›ÜHr¹³\DWD‹tHrÕRtBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD›ÜHr¹³\DWD‹tHrÕRt......Phase 3A@..DW6DWÆ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081854100818541008.DW6B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÆ.DW6 AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD›ÜHr¹³\DWD‹tHrÕRtBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD›ÜHr¹³\DWD‹tHrÕRt......Phase 3A@..DW6DWÆ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081855100818551008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:DW×.DW: AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD ÈHr¹¸HDWDÒHrÕ™BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD ÈHr¹¸HDWDÒHrÕ™......Phase 3A@..DW:DW×12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081855100818551008.DW:B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:DW×.DW: AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD ÈHr¹¸HDWDÒHrÕ™BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD ÈHr¹¸HDWDÒHrÕ™......Phase 3A@..DW:DW×12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081856100818561008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÅDW: AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£ÔHr¹»TDW¨DŽ¼HsŠ¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£ÔHr¹»TDWD†LHrÕMLDW“DÊ€HsuDW¨DŽ¼HsŠ¼Phase 3A@..DW:.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081856100818561008.DW:B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÅDW: AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£ÔHr¹»TDW¨DŽ¼HsŠ¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£ÔHr¹»TDWD†LHrÕMLDW“DÊ€HsuDW¨DŽ¼HsŠ¼Phase 3A@..DW:.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081856100818561008DW“DW“BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÅDW: AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£ÔHr¹»TDW¨DŽ¼HsŠ¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£ÔHr¹»TDWD†LHrÕMLDW“DÊ€HsuDW¨DŽ¼HsŠ¼Phase 3A@..DW:.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081856100818561008.DWÅBÁOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÅDW:YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£ÔHr¹»TDW¨DŽ¼HsŠ¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£ÔHr¹»TDWD†LHrÕMLDW“DÊ€HsuDW¨DŽ¼HsŠ¼Phase 3A@..DW:.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081857100818571008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÊ.DW7 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÓ¤Hr¹ë$DWD×ÜHrÖð\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÓ¤Hr¹ë$DWD×ÜHrÖð\......Phase 3A@..DW7DWÊ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081857100818571008.DW7B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÊ.DW7 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÓ¤Hr¹ë$DWD×ÜHrÖð\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÓ¤Hr¹ë$DWD×ÜHrÖð\......Phase 3A@..DW7DWÊ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081858100818581008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWiDW7 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒðHr¹êpDWKDÐ˜Hs1Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW8DWK.DW7Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒðHr¹êpDWD× HrÖð DW8D±lHrýlDWKDÐ˜Hs1Phase 3A@..DW7.12-15 YearsA YNN. DW6DWýDWýAðYEARSDSAC4591001C4591001 1008 10081858100818581008.DW7B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWiDW7 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒðHr¹êpDWKDÐ˜Hs1Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW8DWK.DW7Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒðHr¹êpDWD× HrÖð DW8D±lHrýlDWKDÐ˜Hs1Phase 3A@..DW7.12-15 YearsA YNN. DW6DWýDWýAðYEARSDSA C4591001C4591001 1008 10081858100818581008DW8DW8B4REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWiDW7 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒðHr¹êpDWKDÐ˜Hs1Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW8DWK.DW7Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒðHr¹êpDWD× HrÖð DW8D±lHrýlDWKDÐ˜Hs1Phase 3A@..DW7.12-15 YearsA YNN. DW6DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081858100818581008.DWiBeOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWiDW7YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒðHr¹êpDWKDÐ˜Hs1Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW8DWK.DW7Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒðHr¹êpDWD× HrÖð DW8D±lHrýlDWKDÐ˜Hs1Phase 3A@..DW7.12-15 YearsA YNN. DW6DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081859100818591008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:DWÉ.DW: AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÕHHr¹ìÈDWD¥´HrÕl´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÕHHr¹ìÈDWD¥´HrÕl´......Phase 3A@..DW:DWÉ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081859100818591008.DW:B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:DWÉ.DW: AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÕHHr¹ìÈDWD¥´HrÕl´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÕHHr¹ìÈDWD¥´HrÕl´......Phase 3A@..DW:DWÉ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081860100818601008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÐ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÖ°Hr¹î0DWDÆHrÕBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÖ°Hr¹î0DWDÆHrÕ......Phase 3A@..DW6DWÐ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081860100818601008.DW6B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÐ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÖ°Hr¹î0DWDÆHrÕBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÖ°Hr¹î0DWDÆHrÕ......Phase 3A@..DW6DWÐ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081861100818611008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW½DW8 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD’|Hrºû|DW¡DÅXHs‡†ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD’|Hrºû|DWD«HrÕrDWŽDÍHsn‚DW¡DÅXHs‡†ØPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081861100818611008.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW½DW8 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD’|Hrºû|DW¡DÅXHs‡†ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD’|Hrºû|DWD«HrÕrDWŽDÍHsn‚DW¡DÅXHs‡†ØPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081861100818611008DWŽDWŽB‰REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW½DW8 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD’|Hrºû|DW¡DÅXHs‡†ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD’|Hrºû|DWD«HrÕrDWŽDÍHsn‚DW¡DÅXHs‡†ØPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081861100818611008.DW½B¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW½DW8YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD’|Hrºû|DW¡DÅXHs‡†ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD’|Hrºû|DWD«HrÕrDWŽDÍHsn‚DW¡DÅXHs‡†ØPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081862100818621008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWâ.DW8 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDž4Hr»4DWDpHr×ùpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDž4Hr»4DWDpHr×ùp......Phase 3A@..DW8DWâ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081862100818621008.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWâ.DW8 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDž4Hr»4DWDpHr×ùpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDž4Hr»4DWDpHr×ùp......Phase 3A@..DW8DWâ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081863100818631008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÃDW7 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD PHr» PDW¦D‰XHsâXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD PHr» PDWDøHrÕdøDW‘D‰ÐHsr3PDW¦D‰XHsâXPhase 3A@..DW7.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081863100818631008.DW7B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÃDW7 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD PHr» PDW¦D‰XHsâXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD PHr» PDWDøHrÕdøDW‘D‰ÐHsr3PDW¦D‰XHsâXPhase 3A@..DW7.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081863100818631008DW‘DW‘BŒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÃDW7 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD PHr» PDW¦D‰XHsâXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD PHr» PDWDøHrÕdøDW‘D‰ÐHsr3PDW¦D‰XHsâXPhase 3A@..DW7.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081863100818631008.DWÃB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÃDW7YAÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD PHr» PDW¦D‰XHsâXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD PHr» PDWDøHrÕdøDW‘D‰ÐHsr3PDW¦D‰XHsâXPhase 3A@..DW7.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081864100818641008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7DW×.DW7 AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡|Hr» |DWD€HrÕd€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡|Hr» |DWD€HrÕd€......Phase 3A@..DW7DW×12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081864100818641008.DW7B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7DW×.DW7 AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡|Hr» |DWD€HrÕd€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡|Hr» |DWD€HrÕd€......Phase 3A@..DW7DW×12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081865100818651008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÊ.DW7 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¢äHr»äDWDÐ˜HrÖéBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¢äHr»äDWDÐ˜HrÖé......Phase 3A@..DW7DWÊ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081865100818651008.DW7B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÊ.DW7 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¢äHr»äDWDÐ˜HrÖéBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¢äHr»äDWDÐ˜HrÖé......Phase 3A@..DW7DWÊ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081866100818661008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¿DW8 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÏäHr»8äDW£D‰ÐHs‰îPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÏäHr»8äDWD´HrÕ{DWŽDØHsnEØDW£D‰ÐHs‰îPPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081866100818661008.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¿DW8 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÏäHr»8äDW£D‰ÐHs‰îPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÏäHr»8äDWD´HrÕ{DWŽDØHsnEØDW£D‰ÐHs‰îPPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081866100818661008DWŽDWŽB‰REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¿DW8 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÏäHr»8äDW£D‰ÐHs‰îPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÏäHr»8äDWD´HrÕ{DWŽDØHsnEØDW£D‰ÐHs‰îPPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081866100818661008.DW¿BºOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¿DW8YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÏäHr»8äDW£D‰ÐHs‰îPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÏäHr»8äDWD´HrÕ{DWŽDØHsnEØDW£D‰ÐHs‰îPPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081867100818671008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¿DW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐÔHr»9ÔDW£DŠHs‰îŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐÔHr»9ÔDWD´´HrÕ{´DWŽD‘ÈHsnFÈDW£DŠHs‰îŒPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081867100818671008.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¿DW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐÔHr»9ÔDW£DŠHs‰îŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐÔHr»9ÔDWD´´HrÕ{´DWŽD‘ÈHsnFÈDW£DŠHs‰îŒPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081867100818671008DWŽDWŽB‰REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¿DW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐÔHr»9ÔDW£DŠHs‰îŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐÔHr»9ÔDWD´´HrÕ{´DWŽD‘ÈHsnFÈDW£DŠHs‰îŒPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081867100818671008.DW¿BºOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¿DW8YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐÔHr»9ÔDW£DŠHs‰îŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐÔHr»9ÔDWD´´HrÕ{´DWŽD‘ÈHsnFÈDW£DŠHs‰îŒPhase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081868100818681008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒHr»;DWDÁÔHrÖÚTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒHr»;DWDÁÔHrÖÚT......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081868100818681008.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒHr»;DWDÁÔHrÖÚTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒHr»;DWDÁÔHrÖÚT......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081869100818691008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DW½DW9 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÕüHr»>üDW¡D¡¸Hs‡c8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕüHr»>üDWD|tHrÖ”ôDWŽD”ÔHsnIÔDW¡D¡¸Hs‡c8Phase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081869100818691008.DW9B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DW½DW9 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÕüHr»>üDW¡D¡¸Hs‡c8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕüHr»>üDWD|tHrÖ”ôDWŽD”ÔHsnIÔDW¡D¡¸Hs‡c8Phase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081869100818691008DWŽDWŽB‰REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DW½DW9 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÕüHr»>üDW¡D¡¸Hs‡c8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕüHr»>üDWD|tHrÖ”ôDWŽD”ÔHsnIÔDW¡D¡¸Hs‡c8Phase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081869100818691008.DW½B¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DW½DW9YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÕüHr»>üDW¡D¡¸Hs‡c8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕüHr»>üDWD|tHrÖ”ôDWŽD”ÔHsnIÔDW¡D¡¸Hs‡c8Phase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081870100818701008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÆ.DW9 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÚ¬Hr»C¬DWD¬€HrÕs€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÚ¬Hr»C¬DWD¬€HrÕs€......Phase 3A@..DW9DWÆ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081870100818701008.DW9B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÆ.DW9 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÚ¬Hr»C¬DWD¬€HrÕs€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÚ¬Hr»C¬DWD¬€HrÕs€......Phase 3A@..DW9DWÆ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081871100818711008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWT.DW¿DWT AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–Hr¼P€DW¢D»DHsˆÎDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DWDW¢.DWŒPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–Hr¼P€DWD–Hr¼P€DWDÏ0Hsm2°DW¢D»DHsˆÎDPhase 3A@.DWTDWT.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081871100818711008DWDWB‡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWT.DW¿DWT AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–Hr¼P€DW¢D»DHsˆÎDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DWDW¢.DWŒPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–Hr¼P€DWD–Hr¼P€DWDÏ0Hsm2°DW¢D»DHsˆÎDPhase 3A@.DWTDWT.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081871100818711008.DW¿B¹OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWT.DW¿DWTYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–Hr¼P€DW¢D»DHsˆÎDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DWDW¢.DWŒPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–Hr¼P€DWD–Hr¼P€DWDÏ0Hsm2°DW¢D»DHsˆÎDPhase 3A@.DWTDWT.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081871100818711008.DWTBNVACCINATION BDISPOSITION EVENTOTHER Ap2nd vax not given due to confirmed covid illness prior to vax #2 DWT.DW¿DWT AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–Hr¼P€DW¢D»DHsˆÎDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DWDW¢.DWŒPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–Hr¼P€DWD–Hr¼P€DWDÏ0Hsm2°DW¢D»DHsˆÎDPhase 3A@.DWTDWT.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA`C4591001C4591001 1008 10081872100818721008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:.DW DW: AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD€Hr¼XDW~DÐÔHsYmÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWkDW~.DWiPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD€Hr¼XDWDÌ$HrÚÙ$DWkDÑÄHs@bDDW~DÐÔHsYmÔPhase 3A@..DW:.12-15 YearsA YNN. DWhDWýDWýAðYEARSDSAC4591001C4591001 1008 10081872100818721008.DW:B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DW DW: AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD€Hr¼XDW~DÐÔHsYmÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWkDW~.DWiPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD€Hr¼XDWDÌ$HrÚÙ$DWkDÑÄHs@bDDW~DÐÔHsYmÔPhase 3A@..DW:.12-15 YearsA YNN. DWhDWýDWýAðYEARSDSA C4591001C4591001 1008 10081872100818721008DWkDWkBeREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DW DW: AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD€Hr¼XDW~DÐÔHsYmÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWkDW~.DWiPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD€Hr¼XDWDÌ$HrÚÙ$DWkDÑÄHs@bDDW~DÐÔHsYmÔPhase 3A@..DW:.12-15 YearsA YNN. DWhDWýDWýAðYEARSDSA0C4591001C4591001 1008 10081872100818721008.DW BšOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DW DW:YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD€Hr¼XDW~DÐÔHsYmÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWkDW~.DWiPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD€Hr¼XDWDÌ$HrÚÙ$DWkDÑÄHs@bDDW~DÐÔHsYmÔPhase 3A@..DW:.12-15 YearsA YNN. DWhDWýDWýAðYEARSDSA@C4591001C4591001 1008 10081873100818731008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÛ.DW9 AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDžpHr¼XðDWDƒHrÕJBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDžpHr¼XðDWDƒHrÕJ......Phase 3A@..DW9DWÛ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081873100818731008.DW9B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÛ.DW9 AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDžpHr¼XðDWDƒHrÕJBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDžpHr¼XðDWDƒHrÕJ......Phase 3A@..DW9DWÛ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081874100818741008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¥<Hr¼_¼DWDØHr×úØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¥<Hr¼_¼DWDØHr×úØ......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081874100818741008.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¥<Hr¼_¼DWDØHr×úØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¥<Hr¼_¼DWDØHr×úØ......Phase 3A@..DW8DWË12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081875100818751008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¾DW8 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¦,Hr¼`¬DW¢D$Hsˆ”$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¦,Hr¼`¬DWDœHr×úœDWDƒ¸Hslç8DW¢D$Hsˆ”$Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081875100818751008.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¾DW8 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¦,Hr¼`¬DW¢D$Hsˆ”$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¦,Hr¼`¬DWDœHr×úœDWDƒ¸Hslç8DW¢D$Hsˆ”$Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081875100818751008DWDWB‡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¾DW8 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¦,Hr¼`¬DW¢D$Hsˆ”$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¦,Hr¼`¬DWDœHr×úœDWDƒ¸Hslç8DW¢D$Hsˆ”$Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081875100818751008.DW¾B¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DW¾DW8YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¦,Hr¼`¬DW¢D$Hsˆ”$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¦,Hr¼`¬DWDœHr×úœDWDƒ¸Hslç8DW¢D$Hsˆ”$Phase 3A@..DW8.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081876100818761008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÊHr¼„ˆDWD»DHrØ%DBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÊHr¼„ˆDWD»DHrØ%D......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081876100818761008.DW?B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÊHr¼„ˆDWD»DHrØ%DBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÊHr¼„ˆDWD»DHrØ%D......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081877100818771008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÍPHr¼‡ÐDW¦D½$HsŽ$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍPHr¼‡ÐDWDÌØHrØ6ØDW‘DÃ´Hsrm4DW¦D½$HsŽ$Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081877100818771008.DW?B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÍPHr¼‡ÐDW¦D½$HsŽ$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍPHr¼‡ÐDWDÌØHrØ6ØDW‘DÃ´Hsrm4DW¦D½$HsŽ$Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081877100818771008DW‘DW‘B‹REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÍPHr¼‡ÐDW¦D½$HsŽ$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍPHr¼‡ÐDWDÌØHrØ6ØDW‘DÃ´Hsrm4DW¦D½$HsŽ$Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081877100818771008.DWÄB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW?YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÍPHr¼‡ÐDW¦D½$HsŽ$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍPHr¼‡ÐDWDÌØHrØ6ØDW‘DÃ´Hsrm4DW¦D½$HsŽ$Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081878100818781008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÍ.DW8 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÎ¸Hr¼‰8DWDÌ$HrØ6$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÎ¸Hr¼‰8DWDÌ$HrØ6$......Phase 3A@..DW8DWÍ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081878100818781008.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÍ.DW8 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÎ¸Hr¼‰8DWDÌ$HrØ6$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÎ¸Hr¼‰8DWDÌ$HrØ6$......Phase 3A@..DW8DWÍ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081879100818791008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÍ.DW8 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÏäHr¼ŠdDWD—àHrØàPlacebo Placebo 12-15 YearsA . . .DWDW....DWŒPlacebo Placebo Placebo A .Placebo A .DWDÏäHr¼ŠdDWD—àHrØà......Phase 3A@..DW8DWÍ12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081879100818791008.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÍ.DW8 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÏäHr¼ŠdDWD—àHrØàPlacebo Placebo 12-15 YearsA . . .DWDW....DWŒPlacebo Placebo Placebo A .Placebo A .DWDÏäHr¼ŠdDWD—àHrØà......Phase 3A@..DW8DWÍ12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081880100818801008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔÐHr¼PDW§DË4Hsu´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔÐHr¼PDWDÓhHrÖëèDW’DÓàHssÎàDW§DË4Hsu´Phase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081880100818801008.DW9B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔÐHr¼PDW§DË4Hsu´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔÐHr¼PDWDÓhHrÖëèDW’DÓàHssÎàDW§DË4Hsu´Phase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081880100818801008DW’DW’BŒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔÐHr¼PDW§DË4Hsu´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔÐHr¼PDWDÓhHrÖëèDW’DÓàHssÎàDW§DË4Hsu´Phase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081880100818801008.DWÃB½OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔÐHr¼PDW§DË4Hsu´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔÐHr¼PDWDÓhHrÖëèDW’DÓàHssÎàDW§DË4Hsu´Phase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081881100818811008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÕÀHr¼@DW§DËpHsuðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕÀHr¼@DWDÔ”HrÖíDW’DÔXHssÏXDW§DËpHsuðPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081881100818811008.DW9B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÕÀHr¼@DW§DËpHsuðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕÀHr¼@DWDÔ”HrÖíDW’DÔXHssÏXDW§DËpHsuðPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081881100818811008DW’DW’BŒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÕÀHr¼@DW§DËpHsuðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕÀHr¼@DWDÔ”HrÖíDW’DÔXHssÏXDW§DËpHsuðPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081881100818811008.DWÃB½OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÃDW9YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÕÀHr¼@DW§DËpHsuðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕÀHr¼@DWDÔ”HrÖíDW’DÔXHssÏXDW§DËpHsuðPhase 3A@..DW9.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081882100818821008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWì.DW9 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD˜XHr½¤XDWDÒðHrÙŽpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD˜XHr½¤XDWDÒðHrÙŽp......Phase 3A@..DW9DWì12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081882100818821008.DW9B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWì.DW9 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD˜XHr½¤XDWDÒðHrÙŽpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD˜XHr½¤XDWDÒðHrÙŽp......Phase 3A@..DW9DWì12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081883100818831008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÍ.DW@ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD™„Hr½¥„DWDÒ<HrÙ¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‹BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD™„Hr½¥„DWDÒ<HrÙ¼......Phase 3A@..DW@DWÍ12-15 YearsA YNY. DWŠDWýDWýAðYEARSDSAC4591001C4591001 1008 10081883100818831008.DW@B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÍ.DW@ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD™„Hr½¥„DWDÒ<HrÙ¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‹BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD™„Hr½¥„DWDÒ<HrÙ¼......Phase 3A@..DW@DWÍ12-15 YearsA YNY. DWŠDWýDWýAðYEARSDSA C4591001C4591001 1008 10081884100818841008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWV.DWÆDWV AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡¸Hr½¸DW¢D¹ÜHsˆÌÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DWDW¢.DWŒPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡¸Hr½¸DWD¡¸Hr½¸DWDæ(HsmI¨DW¢D¹ÜHsˆÌÜPhase 3A@.DWVDWV.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081884100818841008DWDWB†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWV.DWÆDWV AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡¸Hr½¸DW¢D¹ÜHsˆÌÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DWDW¢.DWŒPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡¸Hr½¸DWD¡¸Hr½¸DWDæ(HsmI¨DW¢D¹ÜHsˆÌÜPhase 3A@.DWVDWV.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081884100818841008.DWÆB¿OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWV.DWÆDWVYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡¸Hr½¸DW¢D¹ÜHsˆÌÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DWDW¢.DWŒPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡¸Hr½¸DWD¡¸Hr½¸DWDæ(HsmI¨DW¢D¹ÜHsˆÌÜPhase 3A@.DWVDWV.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081884100818841008.DWVBOVACCINATION BDISPOSITION EVENTOTHER Ap2nd vax not given due to confirmed covid illness prior to vax #2 DWV.DWÆDWV AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡¸Hr½¸DW¢D¹ÜHsˆÌÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DWDW¢.DWŒPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡¸Hr½¸DWD¡¸Hr½¸DWDæ(HsmI¨DW¢D¹ÜHsˆÌÜPhase 3A@.DWVDWV.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSApC4591001C4591001 1008 10081885100818851008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÒ.DW9 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¦¤Hr½²¤DWD‰HrÙDœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¦¤Hr½²¤DWD‰HrÙDœ......Phase 3A@..DW9DWÒ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081885100818851008.DW9B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÒ.DW9 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¦¤Hr½²¤DWD‰HrÙDœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¦¤Hr½²¤DWD‰HrÙDœ......Phase 3A@..DW9DWÒ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081886100818861008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÒ.DW9 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD§XHr½³XDWD‰ÐHrÙEPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD§XHr½³XDWD‰ÐHrÙEP......Phase 3A@..DW9DWÒ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081886100818861008.DW9B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÒ.DW9 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD§XHr½³XDWD‰ÐHrÙEPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD§XHr½³XDWD‰ÐHrÙEP......Phase 3A@..DW9DWÒ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081887100818871008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¾DW= AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHrÂåäDW¢D€4Hsˆ“4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD“äHrÂåäDW!DÁ\HrÞÂÜDWDèHsmKˆDW¢D€4Hsˆ“4Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081887100818871008.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¾DW= AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHrÂåäDW¢D€4Hsˆ“4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD“äHrÂåäDW!DÁ\HrÞÂÜDWDèHsmKˆDW¢D€4Hsˆ“4Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081887100818871008DWDWB‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¾DW= AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHrÂåäDW¢D€4Hsˆ“4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD“äHrÂåäDW!DÁ\HrÞÂÜDWDèHsmKˆDW¢D€4Hsˆ“4Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081887100818871008.DW¾B³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¾DW=YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHrÂåäDW¢D€4Hsˆ“4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD“äHrÂåäDW!DÁ\HrÞÂÜDWDèHsmKˆDW¢D€4Hsˆ“4Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081888100818881008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¾DW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–HrÂèDW¢DÆHsˆÙPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–HrÂèDW!DÑÄHrÞÓDDWDçTHsmJÔDW¢DÆHsˆÙPhase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081888100818881008.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¾DW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–HrÂèDW¢DÆHsˆÙPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–HrÂèDW!DÑÄHrÞÓDDWDçTHsmJÔDW¢DÆHsˆÙPhase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081888100818881008DWDWB‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¾DW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–HrÂèDW¢DÆHsˆÙPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–HrÂèDW!DÑÄHrÞÓDDWDçTHsmJÔDW¢DÆHsˆÙPhase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081888100818881008.DW¾B³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¾DW=YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–HrÂèDW¢DÆHsˆÙPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–HrÂèDW!DÑÄHrÞÓDDWDçTHsmJÔDW¢DÆHsˆÙPhase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081889100818891008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD PHrÂòPDW!D€pHrÞðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD PHrÂòPDW!D€pHrÞð......Phase 3A@..DW=DW×12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081889100818891008.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD PHrÂòPDW!D€pHrÞðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD PHrÂòPDW!D€pHrÞð......Phase 3A@..DW=DW×12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081890100818901008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŸœHrÂñœDW!D} HrÞ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŸœHrÂñœDW!D} HrÞ ......Phase 3A@..DW=DW×12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081890100818901008.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŸœHrÂñœDW!D} HrÞ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŸœHrÂñœDW!D} HrÞ ......Phase 3A@..DW=DW×12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081891100818911008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡ôHrÂóôDW§D|8Hs&¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡ôHrÂóôDW!D`HrÞ‚àDW’D€4Hss{4DW§D|8Hs&¸Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081891100818911008.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡ôHrÂóôDW§D|8Hs&¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡ôHrÂóôDW!D`HrÞ‚àDW’D€4Hss{4DW§D|8Hs&¸Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081891100818911008DW’DW’B‡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡ôHrÂóôDW§D|8Hs&¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡ôHrÂóôDW!D`HrÞ‚àDW’D€4Hss{4DW§D|8Hs&¸Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081891100818911008.DWÃB¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW=YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡ôHrÂóôDW§D|8Hs&¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW’DW§.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡ôHrÂóôDW!D`HrÞ‚àDW’D€4Hss{4DW§D|8Hs&¸Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081892100818921008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÊDW= AàYEARSMAAMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYPlacebo PLACEBO Placebo PLACEBO DWDÌ`HrÃ`DW®D|8Hs˜a8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌ`HrÃ`DW!DÐ˜HrÞÒDW™D~Hs|´DW®D|8Hs˜a8Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081892100818921008.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÊDW= AàYEARSMAAMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYPlacebo PLACEBO Placebo PLACEBO DWDÌ`HrÃ`DW®D|8Hs˜a8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌ`HrÃ`DW!DÐ˜HrÞÒDW™D~Hs|´DW®D|8Hs˜a8Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081892100818921008DW™DW™BŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÊDW= AàYEARSMAAMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYPlacebo PLACEBO Placebo PLACEBO DWDÌ`HrÃ`DW®D|8Hs˜a8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌ`HrÃ`DW!DÐ˜HrÞÒDW™D~Hs|´DW®D|8Hs˜a8Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081892100818921008.DWÊB¿OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÊDW=YAàYEARSMAAMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYPlacebo PLACEBO Placebo PLACEBO DWDÌ`HrÃ`DW®D|8Hs˜a8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW™DW®.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌ`HrÃ`DW!DÐ˜HrÞÒDW™D~Hs|´DW®D|8Hs˜a8Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081893100818931008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÍŒHrÃŒDW!DÈdHrÞÉäBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÍŒHrÃŒDW!DÈdHrÞÉä......Phase 3A@..DW=DW×12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081893100818931008.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÍŒHrÃŒDW!DÈdHrÞÉäBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÍŒHrÃŒDW!DÈdHrÞÉä......Phase 3A@..DW=DW×12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081894100818941008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWÒ.DWE AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD×ÜHrÃ)ÜDW#DŽHrá2ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD×ÜHrÃ)ÜDW#DŽHrá2ˆ......Phase 3A@..DWEDWÒ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081894100818941008.DWEB:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWÒ.DWE AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD×ÜHrÃ)ÜDW#DŽHrá2ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD×ÜHrÃ)ÜDW#DŽHrá2ˆ......Phase 3A@..DWEDWÒ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081895100818951008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙ€HrÃ+€DW!DÏlHrÞÐìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙ€HrÃ+€DW!DÏlHrÞÐì......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081895100818951008.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙ€HrÃ+€DW!DÏlHrÞÐìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙ€HrÃ+€DW!DÏlHrÞÐì......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081896100818961008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙHrÃ+DW£D¶XHsŠØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙHrÃ+DW!DÎôHrÞÐtDWŽDÈÜHsn}ÜDW£D¶XHsŠØPhase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081896100818961008.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙHrÃ+DW£D¶XHsŠØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙHrÃ+DW!DÎôHrÞÐtDWŽDÈÜHsn}ÜDW£D¶XHsŠØPhase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081896100818961008DWŽDWŽBƒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙHrÃ+DW£D¶XHsŠØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙHrÃ+DW!DÎôHrÞÐtDWŽDÈÜHsn}ÜDW£D¶XHsŠØPhase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081896100818961008.DWÃB¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW=YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙHrÃ+DW£D¶XHsŠØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙHrÃ+DW!DÎôHrÞÐtDWŽDÈÜHsn}ÜDW£D¶XHsŠØPhase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081897100818971008DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÔ.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D™HHrÄ<ÈDW"DŒ Hrßß BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D™HHrÄ<ÈDW"DŒ Hrßß ......Phase 3A@..DWDDWÔ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081897100818971008.DWDB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÔ.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D™HHrÄ<ÈDW"DŒ Hrßß BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D™HHrÄ<ÈDW"DŒ Hrßß ......Phase 3A@..DWDDWÔ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081898100818981008DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¾DW? AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW D›ÜHrÄ?\DW¡D¿@Hs‡€ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D›ÜHrÄ?\DW!D‡xHrÞˆøDWD$Hslä¤DW¡D¿@Hs‡€ÀPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081898100818981008.DW?B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¾DW? AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW D›ÜHrÄ?\DW¡D¿@Hs‡€ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D›ÜHrÄ?\DW!D‡xHrÞˆøDWD$Hslä¤DW¡D¿@Hs‡€ÀPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081898100818981008DWDWBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¾DW? AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW D›ÜHrÄ?\DW¡D¿@Hs‡€ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D›ÜHrÄ?\DW!D‡xHrÞˆøDWD$Hslä¤DW¡D¿@Hs‡€ÀPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081898100818981008.DW¾B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¾DW?YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW D›ÜHrÄ?\DW¡D¿@Hs‡€ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D›ÜHrÄ?\DW!D‡xHrÞˆøDWD$Hslä¤DW¡D¿@Hs‡€ÀPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081899100818991008DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¾DW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DœTHrÄ?ÔDW¡D¿Hs‡€„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DœTHrÄ?ÔDW!D‡ðHrÞ‰pDWDØHslåXDW¡D¿Hs‡€„Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081899100818991008.DW?B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¾DW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DœTHrÄ?ÔDW¡D¿Hs‡€„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DœTHrÄ?ÔDW!D‡ðHrÞ‰pDWDØHslåXDW¡D¿Hs‡€„Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081899100818991008DWDWBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¾DW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DœTHrÄ?ÔDW¡D¿Hs‡€„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DœTHrÄ?ÔDW!D‡ðHrÞ‰pDWDØHslåXDW¡D¿Hs‡€„Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081899100818991008.DW¾B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¾DW?YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DœTHrÄ?ÔDW¡D¿Hs‡€„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DœTHrÄ?ÔDW!D‡ðHrÞ‰pDWDØHslåXDW¡D¿Hs‡€„Phase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081900100819001008DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÏ0HrÄr°DW"DÐ Hrà# BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÏ0HrÄr°DW"DÐ Hrà# ......Phase 3A@..DW>DWÑ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081900100819001008.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÏ0HrÄr°DW"DÐ Hrà# BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÏ0HrÄr°DW"DÐ Hrà# ......Phase 3A@..DW>DWÑ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081901100819011008DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED ..DWgDW5 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÐ˜HrÄtDWKDÅXHs%ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW6DWK.DW3Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÐ˜HrÄtDW"DÑLHrà$LDW6Dš8HrúK8DWKDÅXHs%ØPhase 3A@.DW3..12-15 YearsA YNN. DW2DWýDWýAðYEARSDSAC4591001C4591001 1008 10081901100819011008DW6DW6B*REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED ..DWgDW5 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÐ˜HrÄtDWKDÅXHs%ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW6DWK.DW3Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÐ˜HrÄtDW"DÑLHrà$LDW6Dš8HrúK8DWKDÅXHs%ØPhase 3A@.DW3..12-15 YearsA YNN. DW2DWýDWýAðYEARSDSA C4591001C4591001 1008 10081901100819011008.DWgB[OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED ..DWgDW5YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÐ˜HrÄtDWKDÅXHs%ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW6DWK.DW3Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÐ˜HrÄtDW"DÑLHrà$LDW6Dš8HrúK8DWKDÅXHs%ØPhase 3A@.DW3..12-15 YearsA YNN. DW2DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081901100819011008.DW3B'VACCINATION BDISPOSITION EVENTOTHER Apthe participant is willing/eligible to receive Vaccination 3 ..DWgDW5 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÐ˜HrÄtDWKDÅXHs%ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW6DWK.DW3Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÐ˜HrÄtDW"DÑLHrà$LDW6Dš8HrúK8DWKDÅXHs%ØPhase 3A@.DW3..12-15 YearsA YNN. DW2DWýDWýAðYEARSDSA`C4591001C4591001 1008 10081902100819021008DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW¾DW> AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÓhHrÄvèDW¢DÒ<Hsˆå<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÓhHrÄvèDW"DÂHràDWDä„HsmHDW¢DÒ<Hsˆå<Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081902100819021008.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW¾DW> AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÓhHrÄvèDW¢DÒ<Hsˆå<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÓhHrÄvèDW"DÂHràDWDä„HsmHDW¢DÒ<Hsˆå<Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081902100819021008DWDWBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW¾DW> AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÓhHrÄvèDW¢DÒ<Hsˆå<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÓhHrÄvèDW"DÂHràDWDä„HsmHDW¢DÒ<Hsˆå<Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081902100819021008.DW¾B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW¾DW>YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÓhHrÄvèDW¢DÒ<Hsˆå<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÓhHrÄvèDW"DÂHràDWDä„HsmHDW¢DÒ<Hsˆå<Phase 3A@..DW>.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081903100819031008DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÍ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÔ”HrÄxDW"DŠHHrßÝHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÔ”HrÄxDW"DŠHHrßÝH......Phase 3A@..DW>DWÍ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081903100819031008.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÍ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÔ”HrÄxDW"DŠHHrßÝHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÔ”HrÄxDW"DŠHHrßÝH......Phase 3A@..DW>DWÍ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081904100819041008DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¾DW@ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DØÌHrÄ|LDW¢DÇìHsˆÚìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DØÌHrÄ|LDW"DÄàHrààDWDÛ$Hsm>¤DW¢DÇìHsˆÚìPhase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081904100819041008.DW@B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¾DW@ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DØÌHrÄ|LDW¢DÇìHsˆÚìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DØÌHrÄ|LDW"DÄàHrààDWDÛ$Hsm>¤DW¢DÇìHsˆÚìPhase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081904100819041008DWDWBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¾DW@ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DØÌHrÄ|LDW¢DÇìHsˆÚìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DØÌHrÄ|LDW"DÄàHrààDWDÛ$Hsm>¤DW¢DÇìHsˆÚìPhase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081904100819041008.DW¾B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¾DW@YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DØÌHrÄ|LDW¢DÇìHsˆÚìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DØÌHrÄ|LDW"DÄàHrààDWDÛ$Hsm>¤DW¢DÇìHsˆÚìPhase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081905100819051008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÚ.DWF AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD“0HrÅˆ0DW%DÌœHräBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD“0HrÅˆ0DW%DÌœHrä......Phase 3A@..DWFDWÚ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081905100819051008.DWFB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÚ.DWF AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD“0HrÅˆ0DW%DÌœHräBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD“0HrÅˆ0DW%DÌœHrä......Phase 3A@..DWFDWÚ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081906100819061008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÒ.DWF AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDš8HrÅ8DW#D•LHrá9ÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDš8HrÅ8DW#D•LHrá9Ì......Phase 3A@..DWFDWÒ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081906100819061008.DWFB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÒ.DWF AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDš8HrÅ8DW#D•LHrá9ÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDš8HrÅ8DW#D•LHrá9Ì......Phase 3A@..DWFDWÒ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081907100819071008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¿DW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŸØHrÅ”ØDW£DÆHsŠ*ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŸØHrÅ”ØDW#D‘ÈHrá6HDWŽDÌ$Hsn$DW£DÆHsŠ*ŒPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081907100819071008.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¿DW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŸØHrÅ”ØDW£DÆHsŠ*ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŸØHrÅ”ØDW#D‘ÈHrá6HDWŽDÌ$Hsn$DW£DÆHsŠ*ŒPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081907100819071008DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¿DW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŸØHrÅ”ØDW£DÆHsŠ*ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŸØHrÅ”ØDW#D‘ÈHrá6HDWŽDÌ$Hsn$DW£DÆHsŠ*ŒPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081907100819071008.DW¿B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¿DW?YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŸØHrÅ”ØDW£DÆHsŠ*ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŸØHrÅ”ØDW#D‘ÈHrá6HDWŽDÌ$Hsn$DW£DÆHsŠ*ŒPhase 3A@..DW?.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081908100819081008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDžèHrÅ“èDW#D‘PHrá5ÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDžèHrÅ“èDW#D‘PHrá5Ð......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081908100819081008.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDžèHrÅ“èDW#D‘PHrá5ÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDžèHrÅ“èDW#D‘PHrá5Ð......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081909100819091008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¡@HrÅ–@DW¦D©ìHsŽìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡@HrÅ–@DW#DÑHráuDW“DÆÀHsu@DW¦D©ìHsŽìPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081909100819091008.DWAB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¡@HrÅ–@DW¦D©ìHsŽìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡@HrÅ–@DW#DÑHráuDW“DÆÀHsu@DW¦D©ìHsŽìPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081909100819091008DW“DW“B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¡@HrÅ–@DW¦D©ìHsŽìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡@HrÅ–@DW#DÑHráuDW“DÆÀHsu@DW¦D©ìHsŽìPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081909100819091008.DWÄB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWAYAàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¡@HrÅ–@DW¦D©ìHsŽìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡@HrÅ–@DW#DÑHráuDW“DÆÀHsu@DW¦D©ìHsŽìPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081910100819101008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÙ.DW? AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÏ¨HrÅÄ¨DW#D»¼Hrá`<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÏ¨HrÅÄ¨DW#D»¼Hrá`<......Phase 3A@..DW?DWÙ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081910100819101008.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÙ.DW? AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÏ¨HrÅÄ¨DW#D»¼Hrá`<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÏ¨HrÅÄ¨DW#D»¼Hrá`<......Phase 3A@..DW?DWÙ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081911100819111008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¿DWA AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑHrÅÆDW£D‰Hs‰íœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑHrÅÆDW$D—¤Hrâ¤DWŽDèHsnDèDW£D‰Hs‰íœPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081911100819111008.DWAB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¿DWA AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑHrÅÆDW£D‰Hs‰íœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑHrÅÆDW$D—¤Hrâ¤DWŽDèHsnDèDW£D‰Hs‰íœPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081911100819111008DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¿DWA AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑHrÅÆDW£D‰Hs‰íœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑHrÅÆDW$D—¤Hrâ¤DWŽDèHsnDèDW£D‰Hs‰íœPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081911100819111008.DW¿B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¿DWAYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑHrÅÆDW£D‰Hs‰íœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑHrÅÆDW$D—¤Hrâ¤DWŽDèHsnDèDW£D‰Hs‰íœPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081912100819121008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÚ4HrÅÏ4DW$DÓ,HrâÉ,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÚ4HrÅÏ4DW$DÓ,HrâÉ,......Phase 3A@..DWADWÔ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081912100819121008.DWAB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÚ4HrÅÏ4DW$DÓ,HrâÉ,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÚ4HrÅÏ4DW$DÓ,HrâÉ,......Phase 3A@..DWADWÔ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081913100819131008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD× HrÅÌ DW¦D¿|HsŽ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD× HrÅÌ DW$DÎ@HrâÄ@DW‘DŠ„Hsr4DW¦D¿|HsŽ|Phase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081913100819131008.DWAB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD× HrÅÌ DW¦D¿|HsŽ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD× HrÅÌ DW$DÎ@HrâÄ@DW‘DŠ„Hsr4DW¦D¿|HsŽ|Phase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081913100819131008DW‘DW‘B„REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD× HrÅÌ DW¦D¿|HsŽ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD× HrÅÌ DW$DÎ@HrâÄ@DW‘DŠ„Hsr4DW¦D¿|HsŽ|Phase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081913100819131008.DWÃB¶OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWAYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD× HrÅÌ DW¦D¿|HsŽ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD× HrÅÌ DW$DÎ@HrâÄ@DW‘DŠ„Hsr4DW¦D¿|HsŽ|Phase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081914100819141008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWO.DW½DWO AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÖtHrÅËtDW¡D¾Hs‡”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW3.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÖtHrÅËtDW3DøHröZxDWDÜHsm?”DW¡D¾Hs‡”Phase 3A@..DWO.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081914100819141008.DWOBBVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWO.DW½DWO AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÖtHrÅËtDW¡D¾Hs‡”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW3.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÖtHrÅËtDW3DøHröZxDWDÜHsm?”DW¡D¾Hs‡”Phase 3A@..DWO.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081914100819141008DWDWB€REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWO.DW½DWO AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÖtHrÅËtDW¡D¾Hs‡”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW3.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÖtHrÅËtDW3DøHröZxDWDÜHsm?”DW¡D¾Hs‡”Phase 3A@..DWO.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081914100819141008.DW½B°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWO.DW½DWOYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÖtHrÅËtDW¡D¾Hs‡”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW3.DWDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÖtHrÅËtDW3DøHröZxDWDÜHsm?”DW¡D¾Hs‡”Phase 3A@..DWO.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081915100819151008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD™üHrÆà|DW$D’|Hrâˆ|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD™üHrÆà|DW$D’|Hrâˆ|......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081915100819151008.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD™üHrÆà|DW$D’|Hrâˆ|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD™üHrÆà|DW$D’|Hrâˆ|......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081916100819161008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¼HrÆä<DW$DÍHrâÃBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¼HrÆä<DW$DÍHrâÃ......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081916100819161008.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¼HrÆä<DW$DÍHrâÃBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¼HrÆä<DW$DÍHrâÃ......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081917100819171008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÆDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœHrÆâ˜DW©D{„Hs‘ÉPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDœHrÆâ˜DW$DÌ`HrâÂ`DW“D4HstÛ´DW©D{„Hs‘ÉPhase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081917100819171008.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÆDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœHrÆâ˜DW©D{„Hs‘ÉPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDœHrÆâ˜DW$DÌ`HrâÂ`DW“D4HstÛ´DW©D{„Hs‘ÉPhase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081917100819171008DW“DW“B…REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÆDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœHrÆâ˜DW©D{„Hs‘ÉPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDœHrÆâ˜DW$DÌ`HrâÂ`DW“D4HstÛ´DW©D{„Hs‘ÉPhase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1008 10081917100819171008.DWÆB¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÆDW@YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœHrÆâ˜DW©D{„Hs‘ÉPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDœHrÆâ˜DW$DÌ`HrâÂ`DW“D4HstÛ´DW©D{„Hs‘ÉPhase 3A@..DW@.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1008 10081918100819181008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÏlHrÇìDW$DÆ„Hrâ¼„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÏlHrÇìDW$DÆ„Hrâ¼„......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081918100819181008.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÏlHrÇìDW$DÆ„Hrâ¼„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÏlHrÇìDW$DÆ„Hrâ¼„......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081919100819191008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÅDWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒ<HrÇ¼DW©D»¼Hs’ <Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒ<HrÇ¼DW%DÐÔHräTDW“DÃ<Hsu¼DW©D»¼Hs’ <Phase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081919100819191008.DWAB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÅDWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒ<HrÇ¼DW©D»¼Hs’ <Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒ<HrÇ¼DW%DÐÔHräTDW“DÃ<Hsu¼DW©D»¼Hs’ <Phase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081919100819191008DW“DW“B…REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÅDWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒ<HrÇ¼DW©D»¼Hs’ <Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒ<HrÇ¼DW%DÐÔHräTDW“DÃ<Hsu¼DW©D»¼Hs’ <Phase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081919100819191008.DWÅB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÅDWAYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒ<HrÇ¼DW©D»¼Hs’ <Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW©.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒ<HrÇ¼DW%DÐÔHräTDW“DÃ<Hsu¼DW©D»¼Hs’ <Phase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081920100819201008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÖìHrÇlDW$DÄàHrâºàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÖìHrÇlDW$DÄàHrâºà......Phase 3A@..DWDDW×12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081920100819201008.DWDB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÖìHrÇlDW$DÄàHrâºàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÖìHrÇlDW$DÄàHrâºà......Phase 3A@..DWDDW×12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081921100819211008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWDWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜÈHrÇ#HDW‘DÍŒHsrwPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW|DW‘.DWyPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜÈHrÇ#HDW%DÏ¨Hrä(DW|DÀlHsVºlDW‘DÍŒHsrwPhase 3A@..DWE.12-15 YearsA YNN. DWxDWýDWýAðYEARSDSAC4591001C4591001 1008 10081921100819211008.DWEB7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWDWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜÈHrÇ#HDW‘DÍŒHsrwPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW|DW‘.DWyPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜÈHrÇ#HDW%DÏ¨Hrä(DW|DÀlHsVºlDW‘DÍŒHsrwPhase 3A@..DWE.12-15 YearsA YNN. DWxDWýDWýAðYEARSDSA C4591001C4591001 1008 10081921100819211008DW|DW|BnREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWDWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜÈHrÇ#HDW‘DÍŒHsrwPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW|DW‘.DWyPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜÈHrÇ#HDW%DÏ¨Hrä(DW|DÀlHsVºlDW‘DÍŒHsrwPhase 3A@..DWE.12-15 YearsA YNN. DWxDWýDWýAðYEARSDSA0C4591001C4591001 1008 10081921100819211008.DWBŸOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWDWEYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜÈHrÇ#HDW‘DÍŒHsrwPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW|DW‘.DWyPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜÈHrÇ#HDW%DÏ¨Hrä(DW|DÀlHsVºlDW‘DÍŒHsrwPhase 3A@..DWE.12-15 YearsA YNN. DWxDWýDWýAðYEARSDSA@C4591001C4591001 1008 10081922100819221008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD“0HrÈ+0DW%DÎ¸Hrä8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD“0HrÈ+0DW%DÎ¸Hrä8......Phase 3A@..DWADWÔ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081922100819221008.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD“0HrÈ+0DW%DÎ¸Hrä8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD“0HrÈ+0DW%DÎ¸Hrä8......Phase 3A@..DWADWÔ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081923100819231008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¾DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•HrÈ-DW¢D¤ÄHsˆ·ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD•HrÈ-DW%D‡xHrãÎøDWDÄ¤Hsm($DW¢D¤ÄHsˆ·ÄPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081923100819231008.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¾DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•HrÈ-DW¢D¤ÄHsˆ·ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD•HrÈ-DW%D‡xHrãÎøDWDÄ¤Hsm($DW¢D¤ÄHsˆ·ÄPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081923100819231008DWDWB~REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¾DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•HrÈ-DW¢D¤ÄHsˆ·ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD•HrÈ-DW%D‡xHrãÎøDWDÄ¤Hsm($DW¢D¤ÄHsˆ·ÄPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081923100819231008.DW¾B¯OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¾DWAYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•HrÈ-DW¢D¤ÄHsˆ·ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD•HrÈ-DW%D‡xHrãÎøDWDÄ¤Hsm($DW¢D¤ÄHsˆ·ÄPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081924100819241008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD˜HrÈ0DW£D§XHsŠØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜HrÈ0DW%D‹ìHrãÓlDWŽD“¨HsnH¨DW£D§XHsŠØPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081924100819241008.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD˜HrÈ0DW£D§XHsŠØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜HrÈ0DW%D‹ìHrãÓlDWŽD“¨HsnH¨DW£D§XHsŠØPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081924100819241008DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD˜HrÈ0DW£D§XHsŠØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜HrÈ0DW%D‹ìHrãÓlDWŽD“¨HsnH¨DW£D§XHsŠØPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081924100819241008.DWÃB´OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWAYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD˜HrÈ0DW£D§XHsŠØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜HrÈ0DW%D‹ìHrãÓlDWŽD“¨HsnH¨DW£D§XHsŠØPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081925100819251008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡HrÈ9DW%DÒ<Hrä¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡HrÈ9DW%DÒ<Hrä¼......Phase 3A@..DWADWÙ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081925100819251008.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡HrÈ9DW%DÒ<Hrä¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡HrÈ9DW%DÒ<Hrä¼......Phase 3A@..DWADWÙ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081926100819261008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÕüHrÈmüDW£DÁÔHsŠ&TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕüHrÈmüDW%D»øHräxDWŽDÎHsnƒDW£DÁÔHsŠ&TPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081926100819261008.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÕüHrÈmüDW£DÁÔHsŠ&TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕüHrÈmüDW%D»øHräxDWŽDÎHsnƒDW£DÁÔHsŠ&TPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081926100819261008DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÕüHrÈmüDW£DÁÔHsŠ&TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕüHrÈmüDW%D»øHräxDWŽDÎHsnƒDW£DÁÔHsŠ&TPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081926100819261008.DWÄBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWAYAàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÕüHrÈmüDW£DÁÔHsŠ&TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÕüHrÈmüDW%D»øHräxDWŽDÎHsnƒDW£DÁÔHsŠ&TPhase 3A@..DWA.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081927100819271008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÏ0HrÈg0DW%D»HräˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÏ0HrÈg0DW%D»Hräˆ......Phase 3A@..DWADWÞ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081927100819271008.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÏ0HrÈg0DW%D»HräˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÏ0HrÈg0DW%D»Hräˆ......Phase 3A@..DWADWÞ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081928100819281008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÛ.DWA AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDØTHrÈpTDW%DÊøHräxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDØTHrÈpTDW%DÊøHräx......Phase 3A@..DWADWÛ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081928100819281008.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÛ.DWA AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDØTHrÈpTDW%DÊøHräxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDØTHrÈpTDW%DÊøHräx......Phase 3A@..DWADWÛ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081929100819291008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÛœHrÈsœDW%DÍŒHräBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÛœHrÈsœDW%DÍŒHrä......Phase 3A@..DWEDWØ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081929100819291008.DWEB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÛœHrÈsœDW%DÍŒHräBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÛœHrÈsœDW%DÍŒHrä......Phase 3A@..DWEDWØ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081930100819301008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÃDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–<HrÌ"¼DW£D§ÐHsŠPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–<HrÌ"¼DW(D©8Hrçå8DWDÅXHsm(ØDW£D§ÐHsŠPPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081930100819301008.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÃDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–<HrÌ"¼DW£D§ÐHsŠPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–<HrÌ"¼DW(D©8Hrçå8DWDÅXHsm(ØDW£D§ÐHsŠPPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081930100819301008DWDWB{REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÃDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–<HrÌ"¼DW£D§ÐHsŠPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–<HrÌ"¼DW(D©8Hrçå8DWDÅXHsm(ØDW£D§ÐHsŠPPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081930100819301008.DWÃB±OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÃDWDYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–<HrÌ"¼DW£D§ÐHsŠPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–<HrÌ"¼DW(D©8Hrçå8DWDÅXHsm(ØDW£D§ÐHsŠPPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081931100819311008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÉDWD AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD—àHrÌ$`DW¨DŒÜHsˆÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD—àHrÌ$`DW(DœHrç½œDW“DŽ€HstÛDW¨DŒÜHsˆÜPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081931100819311008.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÉDWD AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD—àHrÌ$`DW¨DŒÜHsˆÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD—àHrÌ$`DW(DœHrç½œDW“DŽ€HstÛDW¨DŒÜHsˆÜPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081931100819311008DW“DW“BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÉDWD AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD—àHrÌ$`DW¨DŒÜHsˆÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD—àHrÌ$`DW(DœHrç½œDW“DŽ€HstÛDW¨DŒÜHsˆÜPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081931100819311008.DWÉB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÉDWDYAÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD—àHrÌ$`DW¨DŒÜHsˆÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD—àHrÌ$`DW(DœHrç½œDW“DŽ€HstÛDW¨DŒÜHsˆÜPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081932100819321008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÄDWD AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD˜ÐHrÌ%PDW¨DTHs‰TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜ÐHrÌ%PDW(D`Hrç½`DW“DŽHstÚˆDW¨DTHs‰TPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081932100819321008.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÄDWD AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD˜ÐHrÌ%PDW¨DTHs‰TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜ÐHrÌ%PDW(D`Hrç½`DW“DŽHstÚˆDW¨DTHs‰TPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081932100819321008DW“DW“BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÄDWD AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD˜ÐHrÌ%PDW¨DTHs‰TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜ÐHrÌ%PDW(D`Hrç½`DW“DŽHstÚˆDW¨DTHs‰TPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081932100819321008.DWÄB²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÄDWDYAàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD˜ÐHrÌ%PDW¨DTHs‰TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW“DW¨.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜ÐHrÌ%PDW(D`Hrç½`DW“DŽHstÚˆDW¨DTHs‰TPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081933100819331008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÂLHrÌNÌDW¦DÆ„HsŽ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÂLHrÌNÌDW)DÉHréV˜DW‘DÌ`HsruàDW¦DÆ„HsŽ„Phase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081933100819331008.DWEB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÂLHrÌNÌDW¦DÆ„HsŽ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÂLHrÌNÌDW)DÉHréV˜DW‘DÌ`HsruàDW¦DÆ„HsŽ„Phase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081933100819331008DW‘DW‘BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÂLHrÌNÌDW¦DÆ„HsŽ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÂLHrÌNÌDW)DÉHréV˜DW‘DÌ`HsruàDW¦DÆ„HsŽ„Phase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081933100819331008.DWÃB±OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWEYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÂLHrÌNÌDW¦DÆ„HsŽ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÂLHrÌNÌDW)DÉHréV˜DW‘DÌ`HsruàDW¦DÆ„HsŽ„Phase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081934100819341008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWØ.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDË4HrÌW´DW(DÑˆHrè ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDË4HrÌW´DW(DÑˆHrè ˆ......Phase 3A@..DWDDWØ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081934100819341008.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWØ.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDË4HrÌW´DW(DÑˆHrè ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDË4HrÌW´DW(DÑˆHrè ˆ......Phase 3A@..DWDDWØ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081935100819351008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWé.DWF AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒ<HrÌ^¼DW*DÈ(Hrê§(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWFBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒ<HrÌ^¼DW*DÈ(Hrê§(......Phase 3A@..DWFDWé12-15 YearsA YNY. DWEDWýDWýAðYEARSDSAC4591001C4591001 1008 10081935100819351008.DWFB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWé.DWF AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒ<HrÌ^¼DW*DÈ(Hrê§(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWFBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒ<HrÌ^¼DW*DÈ(Hrê§(......Phase 3A@..DWFDWé12-15 YearsA YNY. DWEDWýDWýAðYEARSDSA C4591001C4591001 1008 10081936100819361008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DW½DWD AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔXHrÌ`ØDW¡DHs‡OPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔXHrÌ`ØDW(DÌ`Hrè`DWŽD–HsnKDW¡DHs‡OPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081936100819361008.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DW½DWD AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔXHrÌ`ØDW¡DHs‡OPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔXHrÌ`ØDW(DÌ`Hrè`DWŽD–HsnKDW¡DHs‡OPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081936100819361008DWŽDWŽB|REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DW½DWD AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔXHrÌ`ØDW¡DHs‡OPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔXHrÌ`ØDW(DÌ`Hrè`DWŽD–HsnKDW¡DHs‡OPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1008 10081936100819361008.DW½B«OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DW½DWDYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔXHrÌ`ØDW¡DHs‡OPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWŽDW¡.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔXHrÌ`ØDW(DÌ`Hrè`DWŽD–HsnKDW¡DHs‡OPhase 3A@..DWD.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1008 10081937100819371008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙDHrÌeÄDW(DÐ\Hrè\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙDHrÌeÄDW(DÐ\Hrè\......Phase 3A@..DWDDW×12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1008 10081937100819371008.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙDHrÌeÄDW(DÐ\Hrè\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙDHrÌeÄDW(DÐ\Hrè\......Phase 3A@..DWDDW×12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1008 10081938100819381008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÛ`HrÌgàDW¦D HsùPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÛ`HrÌgàDW)DÌœHréZDW‘DŠüHsr4|DW¦D HsùPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081938100819381008.DWEB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÛ`HrÌgàDW¦D HsùPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÛ`HrÌgàDW)DÌœHréZDW‘DŠüHsr4|DW¦D HsùPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081938100819381008DW‘DW‘BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÛ`HrÌgàDW¦D HsùPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÛ`HrÌgàDW)DÌœHréZDW‘DŠüHsr4|DW¦D HsùPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081938100819381008.DWÃB±OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWEYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÛ`HrÌgàDW¦D HsùPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW‘DW¦.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÛ`HrÌgàDW)DÌœHréZDW‘DŠüHsr4|DW¦D HsùPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081940100819401008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¦,HrÍ„,DW)D…˜HréBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¦,HrÍ„,DW)D…˜Hré......Phase 3A@..DWEDWØ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1008 10081940100819401008.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¦,HrÍ„,DW)D…˜HréBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¦,HrÍ„,DW)D…˜Hré......Phase 3A@..DWEDWØ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1008 10081941100819411008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWE AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÌØHrÍªØDW£DÃðHsŠ(pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌØHrÍªØDW)DË4HréX´DWŽDÆ„Hsn{„DW£DÃðHsŠ(pPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1008 10081941100819411008.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWE AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÌØHrÍªØDW£DÃðHsŠ(pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌØHrÍªØDW)DË4HréX´DWŽDÆ„Hsn{„DW£DÃðHsŠ(pPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1008 10081941100819411008DWŽDWŽB{REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWE AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÌØHrÍªØDW£DÃðHsŠ(pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌØHrÍªØDW)DË4HréX´DWŽDÆ„Hsn{„DW£DÃðHsŠ(pPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1008 10081941100819411008.DW¿B¬OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWEYAÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÌØHrÍªØDW£DÃðHsŠ(pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌØHrÍªØDW)DË4HréX´DWŽDÆ„Hsn{„DW£DÃðHsŠ(pPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1008 10081942100819421008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWE AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÍHrÍ«DW£DÃxHsŠ'øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍHrÍ«DW)DË¬HréY,DWŽDÆüHsn{üDW£DÃxHsŠ'øPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081942100819421008.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWE AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÍHrÍ«DW£DÃxHsŠ'øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍHrÍ«DW)DË¬HréY,DWŽDÆüHsn{üDW£DÃxHsŠ'øPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1008 10081942100819421008DWŽDWŽB{REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWE AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÍHrÍ«DW£DÃxHsŠ'øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍHrÍ«DW)DË¬HréY,DWŽDÆüHsn{üDW£DÃxHsŠ'øPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA0C4591001C4591001 1008 10081942100819421008.DW¿B¬OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWEYAðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÍHrÍ«DW£DÃxHsŠ'øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍHrÍ«DW)DË¬HréY,DWŽDÆüHsn{üDW£DÃxHsŠ'øPhase 3A@..DWE.12-15 YearsA YNN. DW‹DWýDWýAðYEARSDSA@C4591001C4591001 1008 10081943100819431008DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWà.DWF AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÎ@HrÍ¬@DW)DÒ´Hré`4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÎ@HrÍ¬@DW)DÒ´Hré`4......Phase 3A@..DWFDWà12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1008 10081943100819431008.DWFB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWà.DWF AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÎ@HrÍ¬@DW)DÒ´Hré`4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÎ@HrÍ¬@DW)DÒ´Hré`4......Phase 3A@..DWFDWà12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1009 10091204100912041009DV»DV»ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVìDW€.DVì AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»DŽøHrXxDWóDß˜Hsó¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÎ.DWÞDWó.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»DŽøHrXxDVÎDÙøHrqnøDWÞDáðHsØðDWóDß˜Hsó¼Phase 3A@..DVìDW€12-15 YearsA YNN. DW—DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091204100912041009.DVìB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVìDW€.DVì AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»DŽøHrXxDWóDß˜Hsó¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÎ.DWÞDWó.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»DŽøHrXxDVÎDÙøHrqnøDWÞDáðHsØðDWóDß˜Hsó¼Phase 3A@..DVìDW€12-15 YearsA YNN. DW—DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091204100912041009DWÞDWÞC@REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVìDW€.DVì AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»DŽøHrXxDWóDß˜Hsó¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÎ.DWÞDWó.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»DŽøHrXxDVÎDÙøHrqnøDWÞDáðHsØðDWóDß˜Hsó¼Phase 3A@..DVìDW€12-15 YearsA YNN. DW—DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091205100912051009DV»DV»ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVíDW€.DVí AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»D¶XHrX>ØDVÑDëŒHruuBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DVÑ....DW„BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»D¶XHrX>ØDVÑDëŒHruu......Phase 3A@..DVíDW€12-15 YearsAYYNY. DWƒDWýDWýAðYEARSDSAC4591001C4591001 1009 10091205100912051009.DVíB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVíDW€.DVí AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»D¶XHrX>ØDVÑDëŒHruuBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DVÑ....DW„BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»D¶XHrX>ØDVÑDëŒHruu......Phase 3A@..DVíDW€12-15 YearsAYYNY. DWƒDWýDWýAðYEARSDSA C4591001C4591001 1009 10091208100912081009DV»DV»ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVí.DWyDVí AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»D¼pHrXDðDW\DáxHs,«xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÑ.DWHDW\.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D¼pHrXDðDVÑDHru˜DWHD¬DHsDDW\DáxHs,«xPhase 3A@..DVí.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSAC4591001C4591001 1009 10091208100912081009.DVíB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVí.DWyDVí AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»D¼pHrXDðDW\DáxHs,«xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÑ.DWHDW\.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D¼pHrXDðDVÑDHru˜DWHD¬DHsDDW\DáxHs,«xPhase 3A@..DVí.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA C4591001C4591001 1009 10091208100912081009DWHDWHBŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVí.DWyDVí AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»D¼pHrXDðDW\DáxHs,«xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÑ.DWHDW\.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D¼pHrXDðDVÑDHru˜DWHD¬DHsDDW\DáxHs,«xPhase 3A@..DVí.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091208100912081009.DWyB¿OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVí.DWyDVíYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»D¼pHrXDðDW\DáxHs,«xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÑ.DWHDW\.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D¼pHrXDðDVÑDHru˜DWHD¬DHsDDW\DáxHs,«xPhase 3A@..DVí.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091209100912091009DV»DV»ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVëDW~.DVë AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»Dí0HrXu°DVÏDæÜHrrÍ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DVÏ....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»Dí0HrXu°DVÏDæÜHrrÍ\......Phase 3A@..DVëDW~12-15 YearsA YNY. DW”DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091209100912091009.DVëB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVëDW~.DVë AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»Dí0HrXu°DVÏDæÜHrrÍ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DVÏ....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»Dí0HrXu°DVÏDæÜHrrÍ\......Phase 3A@..DVëDW~12-15 YearsA YNY. DW”DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091212100912121009DV¼DV¼ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVû.DWÅDVû AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼D‰HrYcDW©DÙ¼Hs’'<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÛ.DW•DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼D‰HrYcDVÛDé4Hr‚¡´DW•D©ìHsw™lDW©DÙ¼Hs’'<Phase 3A@..DVû.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091212100912121009.DVûB@VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVû.DWÅDVû AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼D‰HrYcDW©DÙ¼Hs’'<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÛ.DW•DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼D‰HrYcDVÛDé4Hr‚¡´DW•D©ìHsw™lDW©DÙ¼Hs’'<Phase 3A@..DVû.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091212100912121009DW•DW•BÚREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVû.DWÅDVû AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼D‰HrYcDW©DÙ¼Hs’'<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÛ.DW•DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼D‰HrYcDVÛDé4Hr‚¡´DW•D©ìHsw™lDW©DÙ¼Hs’'<Phase 3A@..DVû.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091212100912121009.DWÅC OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVû.DWÅDVûYAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼D‰HrYcDW©DÙ¼Hs’'<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÛ.DW•DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼D‰HrYcDVÛDé4Hr‚¡´DW•D©ìHsw™lDW©DÙ¼Hs’'<Phase 3A@..DVû.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091213100912131009DV¼DV¼ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVù.DWrDVù AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼D‘ŒHrYkŒDWSD¼Hs l<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW=DWS.DW7Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼D‘ŒHrYkŒDVÏD× Hrr¾ DW=DÝ¸HsÉ8DWSD¼Hs l<Phase 3A@..DVù.12-15 YearsA YNN. DW6DWýDWýAðYEARSDSAC4591001C4591001 1009 10091213100912131009.DVùB>VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVù.DWrDVù AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼D‘ŒHrYkŒDWSD¼Hs l<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW=DWS.DW7Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼D‘ŒHrYkŒDVÏD× Hrr¾ DW=DÝ¸HsÉ8DWSD¼Hs l<Phase 3A@..DVù.12-15 YearsA YNN. DW6DWýDWýAðYEARSDSA C4591001C4591001 1009 10091213100912131009DW=DW=B‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVù.DWrDVù AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼D‘ŒHrYkŒDWSD¼Hs l<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW=DWS.DW7Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼D‘ŒHrYkŒDVÏD× Hrr¾ DW=DÝ¸HsÉ8DWSD¼Hs l<Phase 3A@..DVù.12-15 YearsA YNN. DW6DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091213100912131009.DWrB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVù.DWrDVùYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼D‘ŒHrYkŒDWSD¼Hs l<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW=DWS.DW7Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼D‘ŒHrYkŒDVÏD× Hrr¾ DW=DÝ¸HsÉ8DWSD¼Hs l<Phase 3A@..DVù.12-15 YearsA YNN. DW6DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091216100912161009DV¼DV¼ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVíDW‡.DVí AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¼D¨HHrY‚HDVÑD£˜Hru-BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¼DVÑ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¼D¨HHrY‚HDVÑD£˜Hru-......Phase 3A@..DVíDW‡12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091216100912161009.DVíB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVíDW‡.DVí AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¼D¨HHrY‚HDVÑD£˜Hru-BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¼DVÑ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¼D¨HHrY‚HDVÑD£˜Hru-......Phase 3A@..DVíDW‡12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091218100912181009DV¼DV¼ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVíDW‡.DVí AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¼D©tHrYƒtDVÑD¥Hru.€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¼DVÑ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¼D©tHrYƒtDVÑD¥Hru.€......Phase 3A@..DVíDW‡12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091218100912181009.DVíB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVíDW‡.DVí AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¼D©tHrYƒtDVÑD¥Hru.€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¼DVÑ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¼D©tHrYƒtDVÑD¥Hru.€......Phase 3A@..DVíDW‡12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091220100912201009DV¿DV¿ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVóDWŽ.DVó AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¿DÃ<Hr]‘¼DVÒD€Hrvx€Placebo Placebo 12-15 YearsA . . .DV¿DVÒ....DWPlacebo Placebo Placebo A .Placebo A .DV¿DÃ<Hr]‘¼DVÒD€Hrvx€......Phase 3A@..DVóDWŽ12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1009 10091220100912201009.DVóB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVóDWŽ.DVó AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¿DÃ<Hr]‘¼DVÒD€Hrvx€Placebo Placebo 12-15 YearsA . . .DV¿DVÒ....DWPlacebo Placebo Placebo A .Placebo A .DV¿DÃ<Hr]‘¼DVÒD€Hrvx€......Phase 3A@..DVóDWŽ12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1009 10091221100912211009DV¿DV¿ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVóDWŽ.DVó AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿DÄhHr]’èDVÒDHrvxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÒ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿DÄhHr]’èDVÒDHrvx......Phase 3A@..DVóDWŽ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1009 10091221100912211009.DVóB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVóDWŽ.DVó AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿DÄhHr]’èDVÒDHrvxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÒ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿DÄhHr]’èDVÒDHrvx......Phase 3A@..DVóDWŽ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1009 10091223100912231009DV¿DV¿ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVñDW„.DVñ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿DÇtHr]•ôDVÕDÇtHrz–ôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÕ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿DÇtHr]•ôDVÕDÇtHrz–ô......Phase 3A@..DVñDW„12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1009 10091223100912231009.DVñB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVñDW„.DVñ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿DÇtHr]•ôDVÕDÇtHrz–ôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÕ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿DÇtHr]•ôDVÕDÇtHrz–ô......Phase 3A@..DVñDW„12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1009 10091226100912261009DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVðDWDWËDVð AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀD¹ÜHr^ÙÜDWªDœHs“;Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÔ.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀD¹ÜHr^ÙÜDVÔDºHry8DW”D¯PHsvMPDWªDœHs“;Phase 3A@..DVðDW12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1009 10091226100912261009.DVðB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWDWËDVð AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀD¹ÜHr^ÙÜDWªDœHs“;Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÔ.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀD¹ÜHr^ÙÜDVÔDºHry8DW”D¯PHsvMPDWªDœHs“;Phase 3A@..DVðDW12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1009 10091226100912261009DW”DW”BÕREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWDWËDVð AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀD¹ÜHr^ÙÜDWªDœHs“;Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÔ.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀD¹ÜHr^ÙÜDVÔDºHry8DW”D¯PHsvMPDWªDœHs“;Phase 3A@..DVðDW12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1009 10091226100912261009.DWËCÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWDWËDVðYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀD¹ÜHr^ÙÜDWªDœHs“;Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÔ.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀD¹ÜHr^ÙÜDVÔDºHry8DW”D¯PHsvMPDWªDœHs“;Phase 3A@..DVðDW12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1009 10091227100912271009DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVòDW‹.DVò AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀDì|Hr_|DVÕDäÀHrz´@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÕ....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀDì|Hr_|DVÕDäÀHrz´@......Phase 3A@DW×.DVòDW‹12-15 YearsA YNY. DW<DW×DW×AðYEARSDSAC4591001C4591001 1009 10091227100912271009.DVòB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVòDW‹.DVò AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀDì|Hr_|DVÕDäÀHrz´@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÕ....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀDì|Hr_|DVÕDäÀHrz´@......Phase 3A@DW×.DVòDW‹12-15 YearsA YNY. DW<DW×DW×AðYEARSDSA C4591001C4591001 1009 10091227100912271009.DW×C€FOLLOW-UP BDISPOSITION EVENTOTHER ApSubject enrolled in C4591031 study DVòDW‹.DVòYAðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀDì|Hr_|DVÕDäÀHrz´@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÕ....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀDì|Hr_|DVÕDäÀHrz´@......Phase 3A@DW×.DVòDW‹12-15 YearsA YNY. DW<DW×DW×AðYEARSDSA@C4591001C4591001 1009 10091229100912291009DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVþ.DWÊDVþ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDóüHr_üDWªDÞ0Hs“}0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀ.DWUDW•DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDóüHr_üDWUDóHs#‚ŒDW•DãXHswÒØDWªDÞ0Hs“}0Phase 3A@..DVþ.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091229100912291009.DWrB³VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVþ.DWÊDVþ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDóüHr_üDWªDÞ0Hs“}0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀ.DWUDW•DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDóüHr_üDWUDóHs#‚ŒDW•DãXHswÒØDWªDÞ0Hs“}0Phase 3A@..DVþ.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091229100912291009DW•DW•BÖREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVþ.DWÊDVþ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDóüHr_üDWªDÞ0Hs“}0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀ.DWUDW•DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDóüHr_üDWUDóHs#‚ŒDW•DãXHswÒØDWªDÞ0Hs“}0Phase 3A@..DVþ.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091229100912291009.DWÊC°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVþ.DWÊDVþYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDóüHr_üDWªDÞ0Hs“}0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀ.DWUDW•DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDóüHr_üDWUDóHs#‚ŒDW•DãXHswÒØDWªDÞ0Hs“}0Phase 3A@..DVþ.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1009 10091231100912311009DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVóDW….DVó AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀEHr_ àDVÔDàHry^BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÔ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀEHr_ àDVÔDàHry^......Phase 3A@..DVóDW…12-15 YearsA YNY. DW’DWýDWýAðYEARSDSAC4591001C4591001 1009 10091231100912311009.DVóB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW….DVó AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀEHr_ àDVÔDàHry^BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÔ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀEHr_ àDVÔDàHry^......Phase 3A@..DVóDW…12-15 YearsA YNY. DW’DWýDWýAðYEARSDSA C4591001C4591001 1009 10091233100912331009DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW†DWÓDV÷ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁD—hHr`èDW¶D§XHs£XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDV×.DW¡DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁD—hHr`èDV×DóHr}eŒDW¡DðxHs‡±øDW¶D§XHs£XPhase 3A@..DV÷DW†12-15 YearsAYYNN. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091233100912331009.DV÷B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW†DWÓDV÷ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁD—hHr`èDW¶D§XHs£XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDV×.DW¡DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁD—hHr`èDV×DóHr}eŒDW¡DðxHs‡±øDW¶D§XHs£XPhase 3A@..DV÷DW†12-15 YearsAYYNN. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091233100912331009DW¡DW¡BáREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW†DWÓDV÷ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁD—hHr`èDW¶D§XHs£XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDV×.DW¡DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁD—hHr`èDV×DóHr}eŒDW¡DðxHs‡±øDW¶D§XHs£XPhase 3A@..DV÷DW†12-15 YearsAYYNN. DW’DWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091233100912331009.DWÓC0OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW†DWÓDV÷YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁD—hHr`èDW¶D§XHs£XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDV×.DW¡DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁD—hHr`èDV×DóHr}eŒDW¡DðxHs‡±øDW¶D§XHs£XPhase 3A@..DV÷DW†12-15 YearsAYYNN. DW’DWýDWýAÀYEARSDSA@C4591001C4591001 1009 10091234100912341009DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVùDW“.DVù AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDÎ@Hr`?ÀDVÖDÄàHr{åàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÖ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDÎ@Hr`?ÀDVÖDÄàHr{åà......Phase 3A@..DVùDW“12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091234100912341009.DVùB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVùDW“.DVù AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDÎ@Hr`?ÀDVÖDÄàHr{åàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÖ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDÎ@Hr`?ÀDVÖDÄàHr{åà......Phase 3A@..DVùDW“12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091237100912371009DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW‹.DV÷ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDÝôHr`OtDV×DÇtHr}9ôPlacebo Placebo 12-15 YearsA . . .DVÁDV×....DWŽPlacebo Placebo Placebo A .Placebo A .DVÁDÝôHr`OtDV×DÇtHr}9ô......Phase 3A@..DV÷DW‹12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1009 10091237100912371009.DV÷B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW‹.DV÷ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDÝôHr`OtDV×DÇtHr}9ôPlacebo Placebo 12-15 YearsA . . .DVÁDV×....DWŽPlacebo Placebo Placebo A .Placebo A .DVÁDÝôHr`OtDV×DÇtHr}9ô......Phase 3A@..DV÷DW‹12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1009 10091238100912381009DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVñ.DW´DVñ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDôtHr`eôDW‘D¸tHsraôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÕ.DW|DW‘.DWkPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDôtHr`eôDVÕDßÔHrz¯TDW|DóHsVíDW‘D¸tHsraôPhase 3A@..DVñ.12-15 YearsA YNN. DWjDWýDWýAðYEARSDSAC4591001C4591001 1009 10091238100912381009.DVñB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVñ.DW´DVñ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDôtHr`eôDW‘D¸tHsraôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÕ.DW|DW‘.DWkPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDôtHr`eôDVÕDßÔHrz¯TDW|DóHsVíDW‘D¸tHsraôPhase 3A@..DVñ.12-15 YearsA YNN. DWjDWýDWýAðYEARSDSA C4591001C4591001 1009 10091238100912381009DW|DW|B¼REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVñ.DW´DVñ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDôtHr`eôDW‘D¸tHsraôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÕ.DW|DW‘.DWkPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDôtHr`eôDVÕDßÔHrz¯TDW|DóHsVíDW‘D¸tHsraôPhase 3A@..DVñ.12-15 YearsA YNN. DWjDWýDWýAðYEARSDSA0C4591001C4591001 1009 10091238100912381009.DW´BôOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVñ.DW´DVñYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDôtHr`eôDW‘D¸tHsraôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÕ.DW|DW‘.DWkPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDôtHr`eôDVÕDßÔHrz¯TDW|DóHsVíDW‘D¸tHsraôPhase 3A@..DVñ.12-15 YearsA YNN. DWjDWýDWýAðYEARSDSA@C4591001C4591001 1009 10091240100912401009DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVðDW†.DVð AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDøèHr`jhDVÔDøpHryvpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÔ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDøèHr`jhDVÔDøpHryvp......Phase 3A@..DVðDW†12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091240100912401009.DVðB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVðDW†.DVð AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDøèHr`jhDVÔDøpHryvpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÔ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDøèHr`jhDVÔDøpHryvp......Phase 3A@..DVðDW†12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091246100912461009DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW„DWÅDV÷ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDáxHra¤xDW§DÞ0Hsˆ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÕ.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂDáxHra¤xDVÕDædHrzµäDW’DßÔHssÚÔDW§DÞ0Hsˆ°Phase 3A@..DV÷DW„12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091246100912461009.DV÷B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW„DWÅDV÷ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDáxHra¤xDW§DÞ0Hsˆ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÕ.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂDáxHra¤xDVÕDædHrzµäDW’DßÔHssÚÔDW§DÞ0Hsˆ°Phase 3A@..DV÷DW„12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091246100912461009DW’DW’BÑREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW„DWÅDV÷ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDáxHra¤xDW§DÞ0Hsˆ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÕ.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂDáxHra¤xDVÕDædHrzµäDW’DßÔHssÚÔDW§DÞ0Hsˆ°Phase 3A@..DV÷DW„12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091246100912461009.DWÅC@OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW„DWÅDV÷YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDáxHra¤xDW§DÞ0Hsˆ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÕ.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂDáxHra¤xDVÕDædHrzµäDW’DßÔHssÚÔDW§DÞ0Hsˆ°Phase 3A@..DV÷DW„12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091247100912471009DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVòDW“.DVò AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂDèDHra«DDVÖDð<Hr|<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVÖ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂDèDHra«DDVÖDð<Hr|<......Phase 3A@..DVòDW“12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091247100912471009.DVòB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVòDW“.DVò AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂDèDHra«DDVÖDð<Hr|<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVÖ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂDèDHra«DDVÖDð<Hr|<......Phase 3A@..DVòDW“12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091249100912491009DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVô.DWÊDVô AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂEXHraØ€DW¨DÙøHsÕøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVØ.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂEXHraØ€DVØD´xHr~xxDW’DÉÌHssÄÌDW¨DÙøHsÕøPhase 3A@..DVô.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1009 10091249100912491009.DVôB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVô.DWÊDVô AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂEXHraØ€DW¨DÙøHsÕøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVØ.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂEXHraØ€DVØD´xHr~xxDW’DÉÌHssÄÌDW¨DÙøHsÕøPhase 3A@..DVô.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1009 10091249100912491009DW’DW’BÑREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVô.DWÊDVô AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂEXHraØ€DW¨DÙøHsÕøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVØ.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂEXHraØ€DVØD´xHr~xxDW’DÉÌHssÄÌDW¨DÙøHsÕøPhase 3A@..DVô.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1009 10091249100912491009.DWÊCOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVô.DWÊDVôYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂEXHraØ€DW¨DÙøHsÕøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVØ.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂEXHraØ€DVØD´xHr~xxDW’DÉÌHssÄÌDW¨DÙøHsÕøPhase 3A@..DVô.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1009 10091250100912501009DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVôDW’.DVô AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂE_€HraØøDVØD³ÄHr~wÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVØ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂE_€HraØøDVØD³ÄHr~wÄ......Phase 3A@..DVôDW’12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091250100912501009.DVôB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVôDW’.DVô AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂE_€HraØøDVØD³ÄHr~wÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVØ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂE_€HraØøDVØD³ÄHr~wÄ......Phase 3A@..DVôDW’12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091265100912651009DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¼.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÒ<Hr–Q<DVÿD‚PHr±°ÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÒ<Hr–Q<DVÿD‚PHr±°Ð......Phase 3A@..DWDW¼12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1009 10091265100912651009.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¼.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÒ<Hr–Q<DVÿD‚PHr±°ÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÒ<Hr–Q<DVÿD‚PHr±°Ð......Phase 3A@..DWDW¼12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1009 10091266100912661009DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWvDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD¡@Hr– @DWZD©8Hs)Ð8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DWGDWZ.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD¡@Hr– @DVþD³ˆHr°ˆDWGD±0HsË°DWZD©8Hs)Ð8Phase 3A@..DW.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSAC4591001C4591001 1009 10091266100912661009.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWvDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD¡@Hr– @DWZD©8Hs)Ð8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DWGDWZ.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD¡@Hr– @DVþD³ˆHr°ˆDWGD±0HsË°DWZD©8Hs)Ð8Phase 3A@..DW.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA C4591001C4591001 1009 10091266100912661009DWGDWGB^REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWvDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD¡@Hr– @DWZD©8Hs)Ð8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DWGDWZ.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD¡@Hr– @DVþD³ˆHr°ˆDWGD±0HsË°DWZD©8Hs)Ð8Phase 3A@..DW.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091266100912661009.DWvBOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWvDWYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD¡@Hr– @DWZD©8Hs)Ð8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DWGDWZ.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD¡@Hr– @DVþD³ˆHr°ˆDWGD±0HsË°DWZD©8Hs)Ð8Phase 3A@..DW.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091267100912671009DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDºÌHr–9ÌDW¦DœHsõPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDºÌHr–9ÌDVÿD·Hr±åŒDW‘D×(Hsr€¨DW¦DœHsõPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091267100912671009.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDºÌHr–9ÌDW¦DœHsõPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDºÌHr–9ÌDVÿD·Hr±åŒDW‘D×(Hsr€¨DW¦DœHsõPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091267100912671009DW‘DW‘B¨REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDºÌHr–9ÌDW¦DœHsõPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDºÌHr–9ÌDVÿD·Hr±åŒDW‘D×(Hsr€¨DW¦DœHsõPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091267100912671009.DWÉBàOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDWYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDºÌHr–9ÌDW¦DœHsõPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDºÌHr–9ÌDVÿD·Hr±åŒDW‘D×(Hsr€¨DW¦DœHsõPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091269100912691009DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDþHr–}DWDý˜Hr³}˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDW....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDþHr–}DWDý˜Hr³}˜......Phase 3A@..DWDW¯12-15 YearsA YNY. DW¯DWýDWýAðYEARSDSAC4591001C4591001 1009 10091269100912691009.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDþHr–}DWDý˜Hr³}˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDW....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDþHr–}DWDý˜Hr³}˜......Phase 3A@..DWDW¯12-15 YearsA YNY. DW¯DWýDWýAðYEARSDSA C4591001C4591001 1009 10091270100912701009DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDþˆHr–}ˆDWDþÄHr³~ÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDW....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDþˆHr–}ˆDWDþÄHr³~Ä......Phase 3A@..DWDW¯12-15 YearsAYYNY. DW¯DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091270100912701009.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDþˆHr–}ˆDWDþÄHr³~ÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDW....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDþˆHr–}ˆDWDþÄHr³~Ä......Phase 3A@..DWDW¯12-15 YearsAYYNY. DW¯DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091272100912721009DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDWæ.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD¾ŒHr—DVÿD³ÄHr±âDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD¾ŒHr—DVÿD³ÄHr±âD......Phase 3A@..DWDWæ12-15 YearsAYYNY. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091272100912721009.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDWæ.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD¾ŒHr—DVÿD³ÄHr±âDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD¾ŒHr—DVÿD³ÄHr±âD......Phase 3A@..DWDWæ12-15 YearsAYYNY. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091273100912731009DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÌDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëD¿Hr—„DWªDÒðHs“qðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW•DWª.DWrPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëD¿Hr—„DVÿD´xHr±âøDW•Då8HswÔ¸DWªDÒðHs“qðPhase 3A@..DW.12-15 YearsAYYNN. DWqDWýDWýAðYEARSDSAC4591001C4591001 1009 10091273100912731009.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÌDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëD¿Hr—„DWªDÒðHs“qðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW•DWª.DWrPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëD¿Hr—„DVÿD´xHr±âøDW•Då8HswÔ¸DWªDÒðHs“qðPhase 3A@..DW.12-15 YearsAYYNN. DWqDWýDWýAðYEARSDSA C4591001C4591001 1009 10091273100912731009DW•DW•B«REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÌDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëD¿Hr—„DWªDÒðHs“qðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW•DWª.DWrPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëD¿Hr—„DVÿD´xHr±âøDW•Då8HswÔ¸DWªDÒðHs“qðPhase 3A@..DW.12-15 YearsAYYNN. DWqDWýDWýAðYEARSDSA0C4591001C4591001 1009 10091273100912731009.DWÌBâOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÌDWYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëD¿Hr—„DWªDÒðHs“qðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW•DWª.DWrPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëD¿Hr—„DVÿD´xHr±âøDW•Då8HswÔ¸DWªDÒðHs“qðPhase 3A@..DW.12-15 YearsAYYNN. DWqDWýDWýAðYEARSDSA@C4591001C4591001 1009 10091274100912741009DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWóDW# AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDû@Hr—ËÀDWÒDy,HsÇÔ,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDW.DW¿DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDû@Hr—ËÀDWD¼Hr¹—<DW¿DËèHs¯hDWÒDy,HsÇÔ,Phase 3A@..DW#.12-15 YearsA YNN. DW¶DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091274100912741009.DW#B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWóDW# AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDû@Hr—ËÀDWÒDy,HsÇÔ,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDW.DW¿DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDû@Hr—ËÀDWD¼Hr¹—<DW¿DËèHs¯hDWÒDy,HsÇÔ,Phase 3A@..DW#.12-15 YearsA YNN. DW¶DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091274100912741009DW¿DW¿BÕREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWóDW# AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDû@Hr—ËÀDWÒDy,HsÇÔ,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDW.DW¿DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDû@Hr—ËÀDWD¼Hr¹—<DW¿DËèHs¯hDWÒDy,HsÇÔ,Phase 3A@..DW#.12-15 YearsA YNN. DW¶DWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091274100912741009.DWóCOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWóDW#YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDû@Hr—ËÀDWÒDy,HsÇÔ,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDW.DW¿DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDû@Hr—ËÀDWD¼Hr¹—<DW¿DËèHs¯hDWÒDy,HsÇÔ,Phase 3A@..DW#.12-15 YearsA YNN. DW¶DWýDWýAÀYEARSDSA@C4591001C4591001 1009 10091275100912751009DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWóDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDúÈHr—ËHDWÒDyhHsÇÔhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDW.DW¿DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDúÈHr—ËHDWDDHr¹–ÄDW¿DÌ$Hs¯¤DWÒDyhHsÇÔhPhase 3A@..DW#.12-15 YearsA YNN. DW¶DWýDWýAðYEARSDSAC4591001C4591001 1009 10091275100912751009.DW#B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWóDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDúÈHr—ËHDWÒDyhHsÇÔhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDW.DW¿DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDúÈHr—ËHDWDDHr¹–ÄDW¿DÌ$Hs¯¤DWÒDyhHsÇÔhPhase 3A@..DW#.12-15 YearsA YNN. DW¶DWýDWýAðYEARSDSA C4591001C4591001 1009 10091275100912751009DW¿DW¿BÕREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWóDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDúÈHr—ËHDWÒDyhHsÇÔhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDW.DW¿DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDúÈHr—ËHDWDDHr¹–ÄDW¿DÌ$Hs¯¤DWÒDyhHsÇÔhPhase 3A@..DW#.12-15 YearsA YNN. DW¶DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091275100912751009.DWóCOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWóDW#YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDúÈHr—ËHDWÒDyhHsÇÔhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDW.DW¿DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDúÈHr—ËHDWDDHr¹–ÄDW¿DÌ$Hs¯¤DWÒDyhHsÇÔhPhase 3A@..DW#.12-15 YearsA YNN. DW¶DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091277100912771009DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÛDW$ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDØHr˜úDW»DÈ Hs©Ñ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW¨DW».DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDØHr˜úDWD»DHr¼uÄDW¨DË¬HsÇ¬DW»DÈ Hs©Ñ Phase 3A@..DW$.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091277100912771009.DW$B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÛDW$ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDØHr˜úDW»DÈ Hs©Ñ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW¨DW».DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDØHr˜úDWD»DHr¼uÄDW¨DË¬HsÇ¬DW»DÈ Hs©Ñ Phase 3A@..DW$.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091277100912771009DW¨DW¨B½REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÛDW$ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDØHr˜úDW»DÈ Hs©Ñ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW¨DW».DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDØHr˜úDWD»DHr¼uÄDW¨DË¬HsÇ¬DW»DÈ Hs©Ñ Phase 3A@..DW$.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091277100912771009.DWÛBðOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÛDW$YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDØHr˜úDW»DÈ Hs©Ñ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW¨DW».DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDØHr˜úDWD»DHr¼uÄDW¨DË¬HsÇ¬DW»DÈ Hs©Ñ Phase 3A@..DW$.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091280100912801009DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìE'@Hr™4tDVÿD’ôHr±ÁtBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìE'@Hr™4tDVÿD’ôHr±Át......Phase 3A@..DWDW°12-15 YearsAYYNY. DWµDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091280100912801009.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìE'@Hr™4tDVÿD’ôHr±ÁtBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìE'@Hr™4tDVÿD’ôHr±Át......Phase 3A@..DWDW°12-15 YearsAYYNY. DWµDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091281100912811009DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDóÀHr™ÀDVÿD“äHr±ÂdBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW±BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDóÀHr™ÀDVÿD“äHr±Âd......Phase 3A@..DWDW°12-15 YearsAYYNY. DW°DWýDWýAàYEARSDSAC4591001C4591001 1009 10091281100912811009.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDóÀHr™ÀDVÿD“äHr±ÂdBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW±BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDóÀHr™ÀDVÿD“äHr±Âd......Phase 3A@..DWDW°12-15 YearsAYYNY. DW°DWýDWýAàYEARSDSA C4591001C4591001 1009 10091282100912821009DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®DWåDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDòHr™DWÉDÅHs¼BœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW´DWÉ.DW¯Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDòHr™DVÿD˜ÐHr±ÇPDW´D×ÜHs ¥ÜDWÉDÅHs¼BœPhase 3A@..DWDW®12-15 YearsA YNN. DW®DWýDWýAàYEARSDSAC4591001C4591001 1009 10091282100912821009.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®DWåDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDòHr™DWÉDÅHs¼BœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW´DWÉ.DW¯Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDòHr™DVÿD˜ÐHr±ÇPDW´D×ÜHs ¥ÜDWÉDÅHs¼BœPhase 3A@..DWDW®12-15 YearsA YNN. DW®DWýDWýAàYEARSDSA C4591001C4591001 1009 10091282100912821009DW´DW´BÉREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®DWåDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDòHr™DWÉDÅHs¼BœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW´DWÉ.DW¯Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDòHr™DVÿD˜ÐHr±ÇPDW´D×ÜHs ¥ÜDWÉDÅHs¼BœPhase 3A@..DWDW®12-15 YearsA YNN. DW®DWýDWýAàYEARSDSA0C4591001C4591001 1009 10091282100912821009.DWåBúOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®DWåDWYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDòHr™DWÉDÅHs¼BœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW´DWÉ.DW¯Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDòHr™DVÿD˜ÐHr±ÇPDW´D×ÜHs ¥ÜDWÉDÅHs¼BœPhase 3A@..DWDW®12-15 YearsA YNN. DW®DWýDWýAàYEARSDSA@C4591001C4591001 1009 10091283100912831009DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW±DWéDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDøpHr™pDWÌD`HsÀ`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW¶DWÌ.DW´Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDøpHr™pDWDŽ€Hr³€DW¶D’|Hs£|DWÌD`HsÀ`Phase 3A@..DW#DW±12-15 YearsA YNN. DW³DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091283100912831009.DW#B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW±DWéDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDøpHr™pDWÌD`HsÀ`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW¶DWÌ.DW´Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDøpHr™pDWDŽ€Hr³€DW¶D’|Hs£|DWÌD`HsÀ`Phase 3A@..DW#DW±12-15 YearsA YNN. DW³DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091283100912831009DW¶DW¶BËREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW±DWéDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDøpHr™pDWÌD`HsÀ`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW¶DWÌ.DW´Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDøpHr™pDWDŽ€Hr³€DW¶D’|Hs£|DWÌD`HsÀ`Phase 3A@..DW#DW±12-15 YearsA YNN. DW³DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091283100912831009.DWéBþOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW±DWéDW#YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDøpHr™pDWÌD`HsÀ`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW¶DWÌ.DW´Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDøpHr™pDWDŽ€Hr³€DW¶D’|Hs£|DWÌD`HsÀ`Phase 3A@..DW#DW±12-15 YearsA YNN. DW³DWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091284100912841009DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW±.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDù$Hr™$DWDŽøHr³øBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDù$Hr™$DWDŽøHr³ø......Phase 3A@..DW#DW±12-15 YearsAYYNY. DW³DWýDWýAðYEARSDSAC4591001C4591001 1009 10091284100912841009.DW#B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW±.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDù$Hr™$DWDŽøHr³øBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDù$Hr™$DWDŽøHr³ø......Phase 3A@..DW#DW±12-15 YearsAYYNY. DW³DWýDWýAðYEARSDSA C4591001C4591001 1009 10091287100912871009DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW±.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD½œHrš1DWDÀlHr³@lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD½œHrš1DWDÀlHr³@l......Phase 3A@DWà.DWDW±12-15 YearsA YNY. DW<DWàDWàAðYEARSDSAC4591001C4591001 1009 10091287100912871009.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW±.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD½œHrš1DWDÀlHr³@lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD½œHrš1DWDÀlHr³@l......Phase 3A@DWà.DWDW±12-15 YearsA YNY. DW<DWàDWàAðYEARSDSA C4591001C4591001 1009 10091287100912871009.DWàBôFOLLOW-UP BDISPOSITION EVENTOTHER ApParticipant enrolled in C4591031 DWDW±.DWYAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD½œHrš1DWDÀlHr³@lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD½œHrš1DWDÀlHr³@l......Phase 3A@DWà.DWDW±12-15 YearsA YNY. DW<DWàDWàAðYEARSDSA@C4591001C4591001 1009 10091288100912881009DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW±.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD¾Hrš1”DWDÀ0Hr³@0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD¾Hrš1”DWDÀ0Hr³@0......Phase 3A@..DWDW±12-15 YearsAYYNY. DW³DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091288100912881009.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW±.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD¾Hrš1”DWDÀ0Hr³@0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD¾Hrš1”DWDÀ0Hr³@0......Phase 3A@..DWDW±12-15 YearsAYYNY. DW³DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091289100912891009DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDÑÄHršEDDWDžèHr³èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDÑÄHršEDDWDžèHr³è......Phase 3A@..DWDWµ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091289100912891009.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDÑÄHršEDDWDžèHr³èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDÑÄHršEDDWDžèHr³è......Phase 3A@..DWDWµ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091292100912921009DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWœDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDÛ`HršNàDWyDåìHsRëlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DWdDWy.DWdPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDÛ`HršNàDWD©ìHr³)ìDWdDèøHs7>øDWyDåìHsRëlPhase 3A@..DW.12-15 YearsA YNN. DWcDWýDWýAðYEARSDSAC4591001C4591001 1009 10091292100912921009.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWœDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDÛ`HršNàDWyDåìHsRëlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DWdDWy.DWdPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDÛ`HršNàDWD©ìHr³)ìDWdDèøHs7>øDWyDåìHsRëlPhase 3A@..DW.12-15 YearsA YNN. DWcDWýDWýAðYEARSDSA C4591001C4591001 1009 10091292100912921009DWdDWdBxREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWœDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDÛ`HršNàDWyDåìHsRëlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DWdDWy.DWdPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDÛ`HršNàDWD©ìHr³)ìDWdDèøHs7>øDWyDåìHsRëlPhase 3A@..DW.12-15 YearsA YNN. DWcDWýDWýAðYEARSDSA0C4591001C4591001 1009 10091292100912921009.DWœB°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWœDWYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDÛ`HršNàDWyDåìHsRëlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DWdDWy.DWdPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDÛ`HršNàDWD©ìHr³)ìDWdDèøHs7>øDWyDåìHsRëlPhase 3A@..DW.12-15 YearsA YNN. DWcDWýDWýAðYEARSDSA@C4591001C4591001 1009 10091293100912931009DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWËDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDúŒHršnDW©D× Hs’% Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW“DW©.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDúŒHršnDWDÅXHr³EXDW“Då°Hsu20DW©D× Hs’% Phase 3A@..DW!.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSAC4591001C4591001 1009 10091293100912931009.DW!B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWËDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDúŒHršnDW©D× Hs’% Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW“DW©.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDúŒHršnDWDÅXHr³EXDW“Då°Hsu20DW©D× Hs’% Phase 3A@..DW!.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA C4591001C4591001 1009 10091293100912931009DW“DW“B§REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWËDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDúŒHršnDW©D× Hs’% Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW“DW©.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDúŒHršnDWDÅXHr³EXDW“Då°Hsu20DW©D× Hs’% Phase 3A@..DW!.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA0C4591001C4591001 1009 10091293100912931009.DWËBßOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWËDW!YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDúŒHršnDW©D× Hs’% Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW“DW©.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDúŒHršnDWDÅXHr³EXDW“Då°Hsu20DW©D× Hs’% Phase 3A@..DW!.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA@C4591001C4591001 1009 10091294100912941009DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW DW! AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD£˜Hrž˜DW~D†ÄHsY#ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWhDW~.DWdPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD£˜Hrž˜DWD‡Hr¹ž€DWhDƒ¸Hs<¸DW~D†ÄHsY#ÄPhase 3A@..DW!.12-15 YearsA YNN. DWcDWýDWýAðYEARSDSAC4591001C4591001 1009 10091294100912941009.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW DW! AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD£˜Hrž˜DW~D†ÄHsY#ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWhDW~.DWdPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD£˜Hrž˜DWD‡Hr¹ž€DWhDƒ¸Hs<¸DW~D†ÄHsY#ÄPhase 3A@..DW!.12-15 YearsA YNN. DWcDWýDWýAðYEARSDSA C4591001C4591001 1009 10091294100912941009DWhDWhByREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW DW! AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD£˜Hrž˜DW~D†ÄHsY#ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWhDW~.DWdPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD£˜Hrž˜DWD‡Hr¹ž€DWhDƒ¸Hs<¸DW~D†ÄHsY#ÄPhase 3A@..DW!.12-15 YearsA YNN. DWcDWýDWýAðYEARSDSA0C4591001C4591001 1009 10091294100912941009.DW B±OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW DW!YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD£˜Hrž˜DW~D†ÄHsY#ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWhDW~.DWdPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD£˜Hrž˜DWD‡Hr¹ž€DWhDƒ¸Hs<¸DW~D†ÄHsY#ÄPhase 3A@..DW!.12-15 YearsA YNN. DWcDWýDWýAðYEARSDSA@C4591001C4591001 1009 10091295100912951009DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÎôHrž6ôDWDÄhHr»-hBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÎôHrž6ôDWDÄhHr»-h......Phase 3A@..DW"DWµ12-15 YearsA YNY. DWµDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091295100912951009.DW"B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÎôHrž6ôDWDÄhHr»-hBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÎôHrž6ôDWDÄhHr»-h......Phase 3A@..DW"DWµ12-15 YearsA YNY. DWµDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091296100912961009DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµDWïDW" AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÎ|Hrž6|DWÍD}dHsÁ@äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW·DWÍ.DW¶Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÎ|Hrž6|DWDÃðHr»,ðDW·DÓhHs¤•èDWÍD}dHsÁ@äPhase 3A@..DW"DWµ12-15 YearsA YNN. DWµDWýDWýAàYEARSDSAC4591001C4591001 1009 10091296100912961009.DW"B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµDWïDW" AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÎ|Hrž6|DWÍD}dHsÁ@äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW·DWÍ.DW¶Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÎ|Hrž6|DWDÃðHr»,ðDW·DÓhHs¤•èDWÍD}dHsÁ@äPhase 3A@..DW"DWµ12-15 YearsA YNN. DWµDWýDWýAàYEARSDSA C4591001C4591001 1009 10091296100912961009DW·DW·BÈREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµDWïDW" AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÎ|Hrž6|DWÍD}dHsÁ@äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW·DWÍ.DW¶Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÎ|Hrž6|DWDÃðHr»,ðDW·DÓhHs¤•èDWÍD}dHsÁ@äPhase 3A@..DW"DWµ12-15 YearsA YNN. DWµDWýDWýAàYEARSDSA0C4591001C4591001 1009 10091296100912961009.DWïCOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµDWïDW"YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÎ|Hrž6|DWÍD}dHsÁ@äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW·DWÍ.DW¶Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDÎ|Hrž6|DWDÃðHr»,ðDW·DÓhHs¤•èDWÍD}dHsÁ@äPhase 3A@..DW"DWµ12-15 YearsA YNN. DWµDWýDWýAàYEARSDSA@C4591001C4591001 1009 10091297100912971009DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DW´.DW" AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÙøHržAøDWD² Hr¹É BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWµBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÙøHržAøDWD² Hr¹É ......Phase 3A@..DW"DW´12-15 YearsA YNY. DW´DWýDWýAàYEARSDSAC4591001C4591001 1009 10091297100912971009.DW"B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DW´.DW" AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÙøHržAøDWD² Hr¹É BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWµBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÙøHržAøDWD² Hr¹É ......Phase 3A@..DW"DW´12-15 YearsA YNY. DW´DWýDWýAàYEARSDSA C4591001C4591001 1009 10091298100912981009DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¼.DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDè¼HržP¼DWDÚ¬Hr¹ò,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDè¼HržP¼DWDÚ¬Hr¹ò,......Phase 3A@..DW!DW¼12-15 YearsAYYNY. DW’DWýDWýAàYEARSDSAC4591001C4591001 1009 10091298100912981009.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¼.DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDè¼HržP¼DWDÚ¬Hr¹ò,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDè¼HržP¼DWDÚ¬Hr¹ò,......Phase 3A@..DW!DW¼12-15 YearsAYYNY. DW’DWýDWýAàYEARSDSA C4591001C4591001 1009 10091300100913001009DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW´.DW$ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDþÄHržfÄDWDÍPHr¹äÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDþÄHržfÄDWDÍPHr¹äÐ......Phase 3A@..DW$DW´12-15 YearsA YNY. DW³DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091300100913001009.DW$B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW´.DW$ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDþÄHržfÄDWDÍPHr¹äÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDþÄHržfÄDWDÍPHr¹äÐ......Phase 3A@..DW$DW´12-15 YearsA YNY. DW³DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091301100913011009DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW×DW$ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDþLHržfLDW´Dæ(Hs ´(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW DW´.DW€Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDþLHržfLDWDÌœHr¹äDW Dû¸Hs†k¸DW´Dæ(Hs ´(Phase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1009 10091301100913011009.DW$B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW×DW$ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDþLHržfLDW´Dæ(Hs ´(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW DW´.DW€Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDþLHržfLDWDÌœHr¹äDW Dû¸Hs†k¸DW´Dæ(Hs ´(Phase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1009 10091301100913011009DW„DW B±REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW×DW$ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDþLHržfLDW´Dæ(Hs ´(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW DW´.DW€Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDþLHržfLDWDÌœHr¹äDW Dû¸Hs†k¸DW´Dæ(Hs ´(Phase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1009 10091301100913011009.DW×BèOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW×DW$YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDþLHržfLDW´Dæ(Hs ´(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW DW´.DW€Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDþLHržfLDWDÌœHr¹äDW Dû¸Hs†k¸DW´Dæ(Hs ´(Phase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAPC4591001C4591001 1009 10091303100913031009DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWéDW% AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD´ðHrŸnpDWÉD¶”Hs¼4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW´DWÉ.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD´ðHrŸnpDWD¹dHr¹ÐäDW´D¿@Hs @DWÉD¶”Hs¼4Phase 3A@..DW%.12-15 YearsA YNN. DW—DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091303100913031009.DW%B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWéDW% AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD´ðHrŸnpDWÉD¶”Hs¼4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW´DWÉ.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD´ðHrŸnpDWD¹dHr¹ÐäDW´D¿@Hs @DWÉD¶”Hs¼4Phase 3A@..DW%.12-15 YearsA YNN. DW—DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091303100913031009DW´DW´BÄREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWéDW% AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD´ðHrŸnpDWÉD¶”Hs¼4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW´DWÉ.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD´ðHrŸnpDWD¹dHr¹ÐäDW´D¿@Hs @DWÉD¶”Hs¼4Phase 3A@..DW%.12-15 YearsA YNN. DW—DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091303100913031009.DWéBùOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWéDW%YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD´ðHrŸnpDWÉD¶”Hs¼4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW´DWÉ.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD´ðHrŸnpDWD¹dHr¹ÐäDW´D¿@Hs @DWÉD¶”Hs¼4Phase 3A@..DW%.12-15 YearsA YNN. DW—DWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091304100913041009DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW».DW$ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDìôHrŸ¦tDWDïHr»XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDìôHrŸ¦tDWDïHr»X......Phase 3A@..DW$DW»12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091304100913041009.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW».DW$ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDìôHrŸ¦tDWDïHr»XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDìôHrŸ¦tDWDïHr»X......Phase 3A@..DW$DW»12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091305100913051009DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW‡DW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDý HrŸ¶ DWkD¬DHs@<ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWVDWk.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDý HrŸ¶ DWD–HrºÿDWVD«THs$ŒTDWkD¬DHs@<ÄPhase 3A@..DW#.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSAC4591001C4591001 1009 10091305100913051009.DW#B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW‡DW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDý HrŸ¶ DWkD¬DHs@<ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWVDWk.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDý HrŸ¶ DWD–HrºÿDWVD«THs$ŒTDWkD¬DHs@<ÄPhase 3A@..DW#.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA C4591001C4591001 1009 10091305100913051009DWVDWVBfREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW‡DW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDý HrŸ¶ DWkD¬DHs@<ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWVDWk.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDý HrŸ¶ DWD–HrºÿDWVD«THs$ŒTDWkD¬DHs@<ÄPhase 3A@..DW#.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091305100913051009.DW‡B—OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW‡DW#YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDý HrŸ¶ DWkD¬DHs@<ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWVDWk.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDý HrŸ¶ DWD–HrºÿDWVD«THs$ŒTDWkD¬DHs@<ÄPhase 3A@..DW#.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091306100913061009DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDü¨HrŸ¶(DW¡DˆàHs‡J`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW¡.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDü¨HrŸ¶(DWD–xHrºÿxDWŽDÍHsn‚DW¡DˆàHs‡J`Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1009 10091306100913061009.DW#B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDü¨HrŸ¶(DW¡DˆàHs‡J`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW¡.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDü¨HrŸ¶(DWD–xHrºÿxDWŽDÍHsn‚DW¡DˆàHs‡J`Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1009 10091306100913061009DWŽDWŽBžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDü¨HrŸ¶(DW¡DˆàHs‡J`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW¡.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDü¨HrŸ¶(DWD–xHrºÿxDWŽDÍHsn‚DW¡DˆàHs‡J`Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1009 10091306100913061009.DWÄBÔOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW#YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDü¨HrŸ¶(DW¡DˆàHs‡J`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW¡.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDü¨HrŸ¶(DWD–xHrºÿxDWŽDÍHsn‚DW¡DˆàHs‡J`Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1009 10091307100913071009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¼.DW# AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD‡xHr ’xDWD‚ÈHr¼=HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW¾BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD‡xHr ’xDWD‚ÈHr¼=H......Phase 3A@DWû.DW#DW¼12-15 YearsA YNY. DW½DWûDWûAðYEARSDSAC4591001C4591001 1009 10091307100913071009.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¼.DW# AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD‡xHr ’xDWD‚ÈHr¼=HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW¾BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD‡xHr ’xDWD‚ÈHr¼=H......Phase 3A@DWû.DW#DW¼12-15 YearsA YNY. DW½DWûDWûAðYEARSDSA C4591001C4591001 1009 10091307100913071009.DWûC FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN Bsubject moved to Texas DW#DW¼.DW#YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD‡xHr ’xDWD‚ÈHr¼=HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW¾BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD‡xHr ’xDWD‚ÈHr¼=H......Phase 3A@DWû.DW#DW¼12-15 YearsA YNY. DW½DWûDWûAðYEARSDSApC4591001C4591001 1009 10091308100913081009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¼.DW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD‡ðHr ’ðDWD‚ŒHr¼=Placebo Placebo 12-15 YearsA . . .DVòDW....DW¾Placebo Placebo Placebo A .Placebo A .DVòD‡ðHr ’ðDWD‚ŒHr¼=......Phase 3A@DWû.DW#DW¼12-15 YearsA YNN. DW½DWûDWûAÐYEARSDSAC4591001C4591001 1009 10091308100913081009.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¼.DW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD‡ðHr ’ðDWD‚ŒHr¼=Placebo Placebo 12-15 YearsA . . .DVòDW....DW¾Placebo Placebo Placebo A .Placebo A .DVòD‡ðHr ’ðDWD‚ŒHr¼=......Phase 3A@DWû.DW#DW¼12-15 YearsA YNN. DW½DWûDWûAÐYEARSDSA C4591001C4591001 1009 10091308100913081009.DWûC FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN Bsubject moved to texas DW#DW¼.DW#YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD‡ðHr ’ðDWD‚ŒHr¼=Placebo Placebo 12-15 YearsA . . .DVòDW....DW¾Placebo Placebo Placebo A .Placebo A .DVòD‡ðHr ’ðDWD‚ŒHr¼=......Phase 3A@DWû.DW#DW¼12-15 YearsA YNN. DW½DWûDWûAÐYEARSDSApC4591001C4591001 1009 10091309100913091009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD¤ˆHr ¯ˆDWDÓàHr»<àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD¤ˆHr ¯ˆDWDÓàHr»<à......Phase 3A@..DW"DWµ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091309100913091009.DW"B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD¤ˆHr ¯ˆDWDÓàHr»<àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD¤ˆHr ¯ˆDWDÓàHr»<à......Phase 3A@..DW"DWµ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091310100913101009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW·.DW( AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD¦hHr ±hDWDÆ„Hr»/„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD¦hHr ±hDWDÆ„Hr»/„......Phase 3A@..DW(DW·12-15 YearsAYYNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1009 10091310100913101009.DW(B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW·.DW( AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD¦hHr ±hDWDÆ„Hr»/„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD¦hHr ±hDWDÆ„Hr»/„......Phase 3A@..DW(DW·12-15 YearsAYYNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1009 10091311100913111009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÊDW! AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÃHr ÎDW§D´xHs^øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÃHr ÎDWDwÄHr¹DDW‘Dì¸Hsr–8DW§D´xHs^øPhase 3A@..DW!.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091311100913111009.DW!B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÊDW! AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÃHr ÎDW§D´xHs^øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÃHr ÎDWDwÄHr¹DDW‘Dì¸Hsr–8DW§D´xHs^øPhase 3A@..DW!.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091311100913111009DW‘DW‘B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÊDW! AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÃHr ÎDW§D´xHs^øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÃHr ÎDWDwÄHr¹DDW‘Dì¸Hsr–8DW§D´xHs^øPhase 3A@..DW!.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091311100913111009.DWÊBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÊDW!YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÃHr ÎDW§D´xHs^øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÃHr ÎDWDwÄHr¹DDW‘Dì¸Hsr–8DW§D´xHs^øPhase 3A@..DW!.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091312100913121009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÙDW) AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÛœHr æœDW¸DÅXHs¥ÙXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW DW¸.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÛœHr æœDWD©ìHr»ìDW DÃHs†3DW¸DÅXHs¥ÙXPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091312100913121009.DW)B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÙDW) AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÛœHr æœDW¸DÅXHs¥ÙXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW DW¸.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÛœHr æœDWD©ìHr»ìDW DÃHs†3DW¸DÅXHs¥ÙXPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091312100913121009DW DW B¯REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÙDW) AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÛœHr æœDW¸DÅXHs¥ÙXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW DW¸.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÛœHr æœDWD©ìHr»ìDW DÃHs†3DW¸DÅXHs¥ÙXPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091312100913121009.DWÙBèOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÙDW)YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÛœHr æœDW¸DÅXHs¥ÙXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW DW¸.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÛœHr æœDWD©ìHr»ìDW DÃHs†3DW¸DÅXHs¥ÙXPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1009 10091313100913131009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW½.DW) AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÚèHr åèDWD©tHr»tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWhBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÚèHr åèDWD©tHr»t......Phase 3A@..DW)DW½12-15 YearsAYYNY. DWgDWýDWýAðYEARSDSAC4591001C4591001 1009 10091313100913131009.DW)B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW½.DW) AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÚèHr åèDWD©tHr»tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWhBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÚèHr åèDWD©tHr»t......Phase 3A@..DW)DW½12-15 YearsAYYNY. DWgDWýDWýAðYEARSDSA C4591001C4591001 1009 10091314100913141009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¼.DW( AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDè¼Hr ó¼DWÞD—,Hs×Ä,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWÃDWÞ.DW¾Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDè¼Hr ó¼DWDÒ<Hr¼Œ¼DWÃDµàHs´J`DWÞD—,Hs×Ä,Phase 3A@..DW(DW¼12-15 YearsAYYNN. DW½DWýDWýAðYEARSDSAC4591001C4591001 1009 10091314100913141009.DW(B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¼.DW( AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDè¼Hr ó¼DWÞD—,Hs×Ä,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWÃDWÞ.DW¾Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDè¼Hr ó¼DWDÒ<Hr¼Œ¼DWÃDµàHs´J`DWÞD—,Hs×Ä,Phase 3A@..DW(DW¼12-15 YearsAYYNN. DW½DWýDWýAðYEARSDSA C4591001C4591001 1009 10091314100913141009DWÃDWÃBÒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW¼.DW( AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDè¼Hr ó¼DWÞD—,Hs×Ä,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWÃDWÞ.DW¾Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDè¼Hr ó¼DWDÒ<Hr¼Œ¼DWÃDµàHs´J`DWÞD—,Hs×Ä,Phase 3A@..DW(DW¼12-15 YearsAYYNN. DW½DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091315100913151009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW´.DW% AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòEB€Hr¡(DWD¼Hr¹µ<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW¯BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòEB€Hr¡(DWD¼Hr¹µ<......Phase 3A@..DW%DW´12-15 YearsAYYNY. DW®DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091315100913151009.DW%B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW´.DW% AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòEB€Hr¡(DWD¼Hr¹µ<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW¯BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòEB€Hr¡(DWD¼Hr¹µ<......Phase 3A@..DW%DW´12-15 YearsAYYNY. DW®DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091316100913161009DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DW‡DW% AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòE7@Hr¡tDWjD“¨Hs>Ò¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWTDWj.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòE7@Hr¡tDWDHr¹´ˆDWTDÔHs"DWjD“¨Hs>Ò¨Phase 3A@..DW%.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSAC4591001C4591001 1009 10091316100913161009.DW%B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DW‡DW% AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòE7@Hr¡tDWjD“¨Hs>Ò¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWTDWj.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòE7@Hr¡tDWDHr¹´ˆDWTDÔHs"DWjD“¨Hs>Ò¨Phase 3A@..DW%.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA C4591001C4591001 1009 10091316100913161009DWTDWTBcREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DW‡DW% AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòE7@Hr¡tDWjD“¨Hs>Ò¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWTDWj.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòE7@Hr¡tDWDHr¹´ˆDWTDÔHs"DWjD“¨Hs>Ò¨Phase 3A@..DW%.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091316100913161009.DW‡B–OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DW‡DW%YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòE7@Hr¡tDWjD“¨Hs>Ò¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWTDWj.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòE7@Hr¡tDWDHr¹´ˆDWTDÔHs"DWjD“¨Hs>Ò¨Phase 3A@..DW%.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091317100913171009DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµDWéDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD Hr¡ü”DWÌDœHsÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW¸DWÌ.DW¶Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD Hr¡ü”DWD·„Hr» „DW¸D°Hs¥ÄDWÌDœHsÀPhase 3A@..DW#DWµ12-15 YearsAYYNN. DWµDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091317100913171009.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµDWéDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD Hr¡ü”DWÌDœHsÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW¸DWÌ.DW¶Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD Hr¡ü”DWD·„Hr» „DW¸D°Hs¥ÄDWÌDœHsÀPhase 3A@..DW#DWµ12-15 YearsAYYNN. DWµDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091317100913171009DW¸DW¸BÆREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµDWéDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD Hr¡ü”DWÌDœHsÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW¸DWÌ.DW¶Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD Hr¡ü”DWD·„Hr» „DW¸D°Hs¥ÄDWÌDœHsÀPhase 3A@..DW#DWµ12-15 YearsAYYNN. DWµDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091317100913171009.DWéB÷OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµDWéDW#YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD Hr¡ü”DWÌDœHsÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW¸DWÌ.DW¶Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD Hr¡ü”DWD·„Hr» „DW¸D°Hs¥ÄDWÌDœHsÀPhase 3A@..DW#DWµ12-15 YearsAYYNN. DWµDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091318100913181009DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµ.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD¸tHr¢ôDWD² Hr» BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD¸tHr¢ôDWD² Hr» ......Phase 3A@..DW#DWµ12-15 YearsAYYNY. DWµDWýDWýAàYEARSDSAC4591001C4591001 1009 10091318100913181009.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµ.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD¸tHr¢ôDWD² Hr» BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD¸tHr¢ôDWD² Hr» ......Phase 3A@..DW#DWµ12-15 YearsAYYNY. DWµDWýDWýAàYEARSDSA C4591001C4591001 1009 10091319100913191009DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DWµ.DW) AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDË4Hr¢'´DWDHrºèBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDË4Hr¢'´DWDHrºè......Phase 3A@..DW)DWµ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1009 10091319100913191009.DW)B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DWµ.DW) AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDË4Hr¢'´DWDHrºèBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDË4Hr¢'´DWDHrºè......Phase 3A@..DW)DWµ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1009 10091320100913201009DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÛDW% AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÍHr¢)”DW»D¥ðHs©®pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW DW».DW Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÍHr¢)”DWDÍÈHr¼ˆHDW Dì@Hs†\@DW»D¥ðHs©®pPhase 3A@..DW%.12-15 YearsA YNN. DWŸDWýDWýAàYEARSDSAC4591001C4591001 1009 10091320100913201009.DW%B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÛDW% AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÍHr¢)”DW»D¥ðHs©®pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW DW».DW Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÍHr¢)”DWDÍÈHr¼ˆHDW Dì@Hs†\@DW»D¥ðHs©®pPhase 3A@..DW%.12-15 YearsA YNN. DWŸDWýDWýAàYEARSDSA C4591001C4591001 1009 10091320100913201009DW DW B®REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÛDW% AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÍHr¢)”DW»D¥ðHs©®pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW DW».DW Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÍHr¢)”DWDÍÈHr¼ˆHDW Dì@Hs†\@DW»D¥ðHs©®pPhase 3A@..DW%.12-15 YearsA YNN. DWŸDWýDWýAàYEARSDSA0C4591001C4591001 1009 10091320100913201009.DWÛBéOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÛDW%YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÍHr¢)”DW»D¥ðHs©®pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW DW».DW Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÍHr¢)”DWDÍÈHr¼ˆHDW Dì@Hs†\@DW»D¥ðHs©®pPhase 3A@..DW%.12-15 YearsA YNN. DWŸDWýDWýAàYEARSDSA@C4591001C4591001 1009 10091321100913211009DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW·.DW% AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÚpHr¢6ðDWDÄ¤Hr¼$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW·BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÚpHr¢6ðDWDÄ¤Hr¼$......Phase 3A@..DW%DW·12-15 YearsAYYNY. DW¶DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091321100913211009.DW%B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW·.DW% AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÚpHr¢6ðDWDÄ¤Hr¼$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW·BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÚpHr¢6ðDWDÄ¤Hr¼$......Phase 3A@..DW%DW·12-15 YearsAYYNY. DW¶DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091322100913221009DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW½.DW$ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDæÜHr¢C\DWDè€Hr¼£BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW¿BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDæÜHr¢C\DWDè€Hr¼£......Phase 3A@..DW$DW½12-15 YearsAYYNY. DW¾DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091322100913221009.DW$B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW½.DW$ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDæÜHr¢C\DWDè€Hr¼£BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW¿BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDæÜHr¢C\DWDè€Hr¼£......Phase 3A@..DW$DW½12-15 YearsAYYNY. DW¾DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091323100913231009DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW½DWóDW$ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDçHr¢DDW×D‹8HsÎ}¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWÃDW×.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDçHr¢DDWDèHr¼¢ˆDWÃD‡Hs´€DW×D‹8HsÎ}¸Phase 3A@..DW$DW½12-15 YearsA YNN. DW¾DWýDWýAðYEARSDSAC4591001C4591001 1009 10091323100913231009.DW$B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW½DWóDW$ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDçHr¢DDW×D‹8HsÎ}¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWÃDW×.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDçHr¢DDWDèHr¼¢ˆDWÃD‡Hs´€DW×D‹8HsÎ}¸Phase 3A@..DW$DW½12-15 YearsA YNN. DW¾DWýDWýAðYEARSDSA C4591001C4591001 1009 10091323100913231009DWÃDWÃBÑREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW½DWóDW$ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDçHr¢DDW×D‹8HsÎ}¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWÃDW×.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDçHr¢DDWDèHr¼¢ˆDWÃD‡Hs´€DW×D‹8HsÎ}¸Phase 3A@..DW$DW½12-15 YearsA YNN. DW¾DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091323100913231009.DWóCOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW½DWóDW$YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDçHr¢DDW×D‹8HsÎ}¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWÃDW×.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDçHr¢DDWDèHr¼¢ˆDWÃD‡Hs´€DW×D‹8HsÎ}¸Phase 3A@..DW$DW½12-15 YearsA YNN. DW¾DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091324100913241009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD–ðHr£DðDWîDì@Hsí1@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÚDWî.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD–ðHr£DðDWDŒ(Hr½˜(DWÚD³ÄHsÒšÄDWîDì@Hsí1@Phase 3A@..DW(DW»12-15 YearsA YNN. DW¼DWýDWýAðYEARSDSAC4591001C4591001 1009 10091324100913241009.DW(B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD–ðHr£DðDWîDì@Hsí1@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÚDWî.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD–ðHr£DðDWDŒ(Hr½˜(DWÚD³ÄHsÒšÄDWîDì@Hsí1@Phase 3A@..DW(DW»12-15 YearsA YNN. DW¼DWýDWýAðYEARSDSA C4591001C4591001 1009 10091324100913241009DWÚDWÚBçREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôD–ðHr£DðDWîDì@Hsí1@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÚDWî.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD–ðHr£DðDWDŒ(Hr½˜(DWÚD³ÄHsÒšÄDWîDì@Hsí1@Phase 3A@..DW(DW»12-15 YearsA YNN. DW¼DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091325100913251009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôD—¤Hr£E¤DWD‹tHr½—tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW½BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôD—¤Hr£E¤DWD‹tHr½—t......Phase 3A@..DW(DW»12-15 YearsA YNY. DW¼DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091325100913251009.DW(B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôD—¤Hr£E¤DWD‹tHr½—tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW½BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôD—¤Hr£E¤DWD‹tHr½—t......Phase 3A@..DW(DW»12-15 YearsA YNY. DW¼DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091326100913261009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÙDW% AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDš8Hr£H8DW¸DàÄHs¥ôÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW›DW¸.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDš8Hr£H8DWDHr¼HDW›D£\Hs{ÜDW¸DàÄHs¥ôÄPhase 3A@..DW%.12-15 YearsA YNN. DW”DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091326100913261009.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÙDW% AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDš8Hr£H8DW¸DàÄHs¥ôÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW›DW¸.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDš8Hr£H8DWDHr¼HDW›D£\Hs{ÜDW¸DàÄHs¥ôÄPhase 3A@..DW%.12-15 YearsA YNN. DW”DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091326100913261009DW›DW›B¨REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÙDW% AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDš8Hr£H8DW¸DàÄHs¥ôÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW›DW¸.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDš8Hr£H8DWDHr¼HDW›D£\Hs{ÜDW¸DàÄHs¥ôÄPhase 3A@..DW%.12-15 YearsA YNN. DW”DWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091326100913261009.DWÙBæOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÙDW%YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDš8Hr£H8DW¸DàÄHs¥ôÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW›DW¸.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDš8Hr£H8DWDHr¼HDW›D£\Hs{ÜDW¸DàÄHs¥ôÄPhase 3A@..DW%.12-15 YearsA YNN. DW”DWýDWýAÀYEARSDSA@C4591001C4591001 1009 10091328100913281009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¿.DW) AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÁÔHr£oÔDWD PHr¼ZÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÁÔHr£oÔDWD PHr¼ZÐ......Phase 3A@..DW)DW¿12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091328100913281009.DW)B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¿.DW) AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÁÔHr£oÔDWD PHr¼ZÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÁÔHr£oÔDWD PHr¼ZÐ......Phase 3A@..DW)DW¿12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091329100913291009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÑDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÁ\Hr£o\DW°DØHs›`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWœDW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÁ\Hr£o\DWD ÈHr¼[HDWœDÊHs€ôDW°DØHs›`Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091329100913291009.DW)B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÑDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÁ\Hr£o\DW°DØHs›`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWœDW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÁ\Hr£o\DWD ÈHr¼[HDWœDÊHs€ôDW°DØHs›`Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091329100913291009DWœDWœB©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÑDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÁ\Hr£o\DW°DØHs›`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWœDW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÁ\Hr£o\DWD ÈHr¼[HDWœDÊHs€ôDW°DØHs›`Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091329100913291009.DWÑBÞOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÑDW)YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÁ\Hr£o\DW°DØHs›`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWœDW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÁ\Hr£o\DWD ÈHr¼[HDWœDÊHs€ôDW°DØHs›`Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091330100913301009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¿DWúDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÀäHr£näDWÙD–xHsÑ+øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÄDWÙ.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÀäHr£näDWDŸØHr¼ZXDWÄD’¸Hsµx¸DWÙD–xHsÑ+øPhase 3A@..DW)DW¿12-15 YearsA YNN. DWÂDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091330100913301009.DW)B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¿DWúDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÀäHr£näDWÙD–xHsÑ+øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÄDWÙ.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÀäHr£näDWDŸØHr¼ZXDWÄD’¸Hsµx¸DWÙD–xHsÑ+øPhase 3A@..DW)DW¿12-15 YearsA YNN. DWÂDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091330100913301009DWÄDWÄBÑREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¿DWúDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÀäHr£näDWÙD–xHsÑ+øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÄDWÙ.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÀäHr£näDWDŸØHr¼ZXDWÄD’¸Hsµx¸DWÙD–xHsÑ+øPhase 3A@..DW)DW¿12-15 YearsA YNN. DWÂDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091330100913301009.DWúCpOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¿DWúDW)YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÀäHr£näDWÙD–xHsÑ+øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÄDWÙ.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÀäHr£näDWDŸØHr¼ZXDWÄD’¸Hsµx¸DWÙD–xHsÑ+øPhase 3A@..DW)DW¿12-15 YearsA YNN. DWÂDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091331100913311009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¸.DW% AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÒðHr£€ðDWD¨„Hr¼cBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÒðHr£€ðDWD¨„Hr¼c......Phase 3A@..DW%DW¸12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091331100913311009.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¸.DW% AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÒðHr£€ðDWD¨„Hr¼cBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÒðHr£€ðDWD¨„Hr¼c......Phase 3A@..DW%DW¸12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091332100913321009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¸.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÓàHr£àDWD¨üHr¼c|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWvBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÓàHr£àDWD¨üHr¼c|......Phase 3A@DWÞ.DW%DW¸12-15 YearsAYYNY. DWuDWÞDWÞAðYEARSDSAC4591001C4591001 1009 10091332100913321009.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¸.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÓàHr£àDWD¨üHr¼c|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWvBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÓàHr£àDWD¨üHr¼c|......Phase 3A@DWÞ.DW%DW¸12-15 YearsAYYNY. DWuDWÞDWÞAðYEARSDSA C4591001C4591001 1009 10091332100913321009.DWÞBëFOLLOW-UP BDISPOSITION EVENTOTHER Apparticipant enrolled in C4591031 DW%DW¸.DW%YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÓàHr£àDWD¨üHr¼c|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWvBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÓàHr£àDWD¨üHr¼c|......Phase 3A@DWÞ.DW%DW¸12-15 YearsAYYNY. DWuDWÞDWÞAðYEARSDSA@C4591001C4591001 1009 10091333100913331009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¶.DW% AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÙøHr£‡øDWDºTHr¼tÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW·BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÙøHr£‡øDWDºTHr¼tÔ......Phase 3A@..DW%DW¶12-15 YearsA YNY. DW¶DWýDWýAàYEARSDSAC4591001C4591001 1009 10091333100913331009.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¶.DW% AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÙøHr£‡øDWDºTHr¼tÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW·BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÙøHr£‡øDWDºTHr¼tÔ......Phase 3A@..DW%DW¶12-15 YearsA YNY. DW¶DWýDWýAàYEARSDSA C4591001C4591001 1009 10091334100913341009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÉDW% AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôEÉ€Hr£º˜DW§Dî\Hs˜ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW“DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôEÉ€Hr£º˜DWD´<Hr½À<DW“Dñ,Hsu=¬DW§Dî\Hs˜ÜPhase 3A@..DW%.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091334100913341009.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÉDW% AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôEÉ€Hr£º˜DW§Dî\Hs˜ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW“DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôEÉ€Hr£º˜DWD´<Hr½À<DW“Dñ,Hsu=¬DW§Dî\Hs˜ÜPhase 3A@..DW%.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091334100913341009DW“DW“B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÉDW% AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôEÉ€Hr£º˜DW§Dî\Hs˜ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW“DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôEÉ€Hr£º˜DWD´<Hr½À<DW“Dñ,Hsu=¬DW§Dî\Hs˜ÜPhase 3A@..DW%.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091334100913341009.DWÉBÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÉDW%YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôEÉ€Hr£º˜DW§Dî\Hs˜ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW“DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôEÉ€Hr£º˜DWD´<Hr½À<DW“Dñ,Hsu=¬DW§Dî\Hs˜ÜPhase 3A@..DW%.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091335100913351009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¼.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÿHr£DWD—àHr½£àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÿHr£DWD—àHr½£à......Phase 3A@..DW%DW¼12-15 YearsAYYNY. DW<DWýDWýAðYEARSDSAC4591001C4591001 1009 10091335100913351009.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¼.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÿHr£DWD—àHr½£àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÿHr£DWD—àHr½£à......Phase 3A@..DW%DW¼12-15 YearsAYYNY. DW<DWýDWýAðYEARSDSA C4591001C4591001 1009 10091336100913361009DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¼.DW% AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÿxHr£xDWáDî˜HsÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÍDWá.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÿxHr£xDWD˜XHr½¤XDWÍDwÄHsÁ;DDWáDî˜HsÜPhase 3A@..DW%DW¼12-15 YearsA YNN. DW¾DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091336100913361009.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¼.DW% AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÿxHr£xDWáDî˜HsÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÍDWá.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÿxHr£xDWD˜XHr½¤XDWÍDwÄHsÁ;DDWáDî˜HsÜPhase 3A@..DW%DW¼12-15 YearsA YNN. DW¾DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091336100913361009DWÍDWÍBÚREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¼.DW% AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÿxHr£xDWáDî˜HsÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWÍDWá.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÿxHr£xDWD˜XHr½¤XDWÍDwÄHsÁ;DDWáDî˜HsÜPhase 3A@..DW%DW¼12-15 YearsA YNN. DW¾DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091337100913371009DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÊDW) AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DDHr§?ÄDW§D¸ìHsclPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DDHr§?ÄDWDÕHHrÃ'HDW’DèHssŠèDW§D¸ìHsclPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091337100913371009.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÊDW) AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DDHr§?ÄDW§D¸ìHsclPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DDHr§?ÄDWDÕHHrÃ'HDW’DèHssŠèDW§D¸ìHsclPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091337100913371009DW’DW’BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÊDW) AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DDHr§?ÄDW§D¸ìHsclPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DDHr§?ÄDWDÕHHrÃ'HDW’DèHssŠèDW§D¸ìHsclPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091337100913371009.DWÊBÔOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÊDW)YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DDHr§?ÄDW§D¸ìHsclPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DDHr§?ÄDWDÕHHrÃ'HDW’DèHssŠèDW§D¸ìHsclPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1009 10091338100913381009DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÄ,Hr§f¬DWæD$HsâI$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷..DWÑDWæ.DWµPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÄ,Hr§f¬DV÷DÄ,Hr§f¬DWÑDHsÆ¦ˆDWæD$HsâI$Phase 3A@.DW DW6.12-15 YearsA YNN. DW´DWýDWýAðYEARSDSAC4591001C4591001 1009 10091338100913381009DWÑDWÑBÛREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÄ,Hr§f¬DWæD$HsâI$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷..DWÑDWæ.DWµPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÄ,Hr§f¬DV÷DÄ,Hr§f¬DWÑDHsÆ¦ˆDWæD$HsâI$Phase 3A@.DW DW6.12-15 YearsA YNN. DW´DWýDWýAðYEARSDSA C4591001C4591001 1009 10091338100913381009.DW BVACCINATION BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABexclusion #5 DW6..DW6 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÄ,Hr§f¬DWæD$HsâI$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷..DWÑDWæ.DWµPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÄ,Hr§f¬DV÷DÄ,Hr§f¬DWÑDHsÆ¦ˆDWæD$HsâI$Phase 3A@.DW DW6.12-15 YearsA YNN. DW´DWýDWýAðYEARSDSApC4591001C4591001 1009 10091339100913391009DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÑ.DW6 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÄ¤Hr§g$DWDš8HrÕa8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWµBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÄ¤Hr§g$DWDš8HrÕa8......Phase 3A@..DW6DWÑ12-15 YearsA YNY. DW´DWýDWýAàYEARSDSAC4591001C4591001 1009 10091339100913391009.DW6B@VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÑ.DW6 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÄ¤Hr§g$DWDš8HrÕa8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWµBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÄ¤Hr§g$DWDš8HrÕa8......Phase 3A@..DW6DWÑ12-15 YearsA YNY. DW´DWýDWýAàYEARSDSA C4591001C4591001 1009 10091340100913401009DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DW¾.DW/ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dé¬Hr§Œ,DWDä„HrÃ6„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dé¬Hr§Œ,DWDä„HrÃ6„......Phase 3A@..DW/DW¾12-15 YearsA YNY. DW’DWýDWýAðYEARSDSAC4591001C4591001 1009 10091340100913401009.DW/B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DW¾.DW/ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dé¬Hr§Œ,DWDä„HrÃ6„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dé¬Hr§Œ,DWDä„HrÃ6„......Phase 3A@..DW/DW¾12-15 YearsA YNY. DW’DWýDWýAðYEARSDSA C4591001C4591001 1009 10091341100913411009DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW»DWóDW, AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷E7@Hr§¥ôDWÒD~HsÇÙPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW¿DWÒ.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷E7@Hr§¥ôDWDòXHrÃDXDW¿D»Hs¯ ˆDWÒD~HsÇÙPhase 3A@..DW,DW»12-15 YearsAYYNN. DW¼DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091341100913411009.DW,B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW»DWóDW, AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷E7@Hr§¥ôDWÒD~HsÇÙPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW¿DWÒ.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷E7@Hr§¥ôDWDòXHrÃDXDW¿D»Hs¯ ˆDWÒD~HsÇÙPhase 3A@..DW,DW»12-15 YearsAYYNN. DW¼DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091341100913411009DW¿DW¿BÉREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW»DWóDW, AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷E7@Hr§¥ôDWÒD~HsÇÙPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW¿DWÒ.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷E7@Hr§¥ôDWDòXHrÃDXDW¿D»Hs¯ ˆDWÒD~HsÇÙPhase 3A@..DW,DW»12-15 YearsAYYNN. DW¼DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091341100913411009.DWóBýOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW»DWóDW,YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷E7@Hr§¥ôDWÒD~HsÇÙPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW¿DWÒ.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷E7@Hr§¥ôDWDòXHrÃDXDW¿D»Hs¯ ˆDWÒD~HsÇÙPhase 3A@..DW,DW»12-15 YearsAYYNN. DW¼DWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091342100913421009DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW».DW, AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷E/ÀHr§¥|DWDñ¤HrÃC¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW½BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷E/ÀHr§¥|DWDñ¤HrÃC¤......Phase 3A@..DW,DW»12-15 YearsAYYNY. DW¼DWýDWýAðYEARSDSAC4591001C4591001 1009 10091342100913421009.DW,B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW».DW, AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷E/ÀHr§¥|DWDñ¤HrÃC¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW½BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷E/ÀHr§¥|DWDñ¤HrÃC¤......Phase 3A@..DW,DW»12-15 YearsAYYNY. DW¼DWýDWýAðYEARSDSA C4591001C4591001 1009 10091343100913431009DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD´xHr¨¨xDW DŸœHrÄCBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWÃBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD´xHr¨¨xDW DŸœHrÄC......Phase 3A@..DW,DW¿12-15 YearsA YNY. DWÂDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091343100913431009.DW,B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD´xHr¨¨xDW DŸœHrÄCBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DWÃBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD´xHr¨¨xDW DŸœHrÄC......Phase 3A@..DW,DW¿12-15 YearsA YNY. DWÂDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091344100913441009DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWvDW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD³ÄHr¨§ÄDWZDàˆHs*ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWDDWZ.DW?Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD³ÄHr¨§ÄDWDª(HrÂü(DWDDåtHs tDWZDàˆHs*ˆPhase 3A@..DW).12-15 YearsA YNN. DW>DWýDWýAðYEARSDSA C4591001C4591001 1009 10091344100913441009.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWvDW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD³ÄHr¨§ÄDWZDàˆHs*ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWDDWZ.DW?Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD³ÄHr¨§ÄDWDª(HrÂü(DWDDåtHs tDWZDàˆHs*ˆPhase 3A@..DW).12-15 YearsA YNN. DW>DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091344100913441009DWDDWDBMREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWvDW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD³ÄHr¨§ÄDWZDàˆHs*ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWDDWZ.DW?Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD³ÄHr¨§ÄDWDª(HrÂü(DWDDåtHs tDWZDàˆHs*ˆPhase 3A@..DW).12-15 YearsA YNN. DW>DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091344100913441009.DWvBOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWvDW)YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD³ÄHr¨§ÄDWZDàˆHs*ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWDDWZ.DW?Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD³ÄHr¨§ÄDWDª(HrÂü(DWDDåtHs tDWZDàˆHs*ˆPhase 3A@..DW).12-15 YearsA YNN. DW>DWýDWýAðYEARSDSAPC4591001C4591001 1009 10091345100913451009DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¼.DW, AÀYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÖ°Hr¨Ê°DW DÒðHrÄvpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW½BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÖ°Hr¨Ê°DW DÒðHrÄvp......Phase 3A@..DW,DW¼12-15 YearsA YNY. DW¼DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091345100913451009.DW,B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¼.DW, AÀYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÖ°Hr¨Ê°DW DÒðHrÄvpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW½BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÖ°Hr¨Ê°DW DÒðHrÄvp......Phase 3A@..DW,DW¼12-15 YearsA YNY. DW¼DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091346100913461009DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DW„DW, AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVøDÖ8Hr¨Ê8DWhDãXHs<XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWUDWh.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖ8Hr¨Ê8DW DÓhHrÄvèDWUDäÀHs#t@DWhDãXHs<XPhase 3A@..DW,.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSAC4591001C4591001 1009 10091346100913461009.DW,B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DW„DW, AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVøDÖ8Hr¨Ê8DWhDãXHs<XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWUDWh.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖ8Hr¨Ê8DW DÓhHrÄvèDWUDäÀHs#t@DWhDãXHs<XPhase 3A@..DW,.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA C4591001C4591001 1009 10091346100913461009DWUDWUB^REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DW„DW, AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVøDÖ8Hr¨Ê8DWhDãXHs<XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWUDWh.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖ8Hr¨Ê8DW DÓhHrÄvèDWUDäÀHs#t@DWhDãXHs<XPhase 3A@..DW,.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091346100913461009.DW„BOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DW„DW,YAðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVøDÖ8Hr¨Ê8DWhDãXHs<XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DWUDWh.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖ8Hr¨Ê8DW DÓhHrÄvèDWUDäÀHs#t@DWhDãXHs<XPhase 3A@..DW,.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091347100913471009DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¾.DW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÚ4Hr¨Î4DWáDäüHsÜ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWÆDWá.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÚ4Hr¨Î4DWDHrÅ’DWÆD¤ÄHs¸-ÄDWáDäüHsÜ|Phase 3A@..DW,DW¾12-15 YearsA YNN. DW¾DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091347100913471009.DW,B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¾.DW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÚ4Hr¨Î4DWáDäüHsÜ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWÆDWá.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÚ4Hr¨Î4DWDHrÅ’DWÆD¤ÄHs¸-ÄDWáDäüHsÜ|Phase 3A@..DW,DW¾12-15 YearsA YNN. DW¾DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091347100913471009DWÆDWÆBÏREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¾.DW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÚ4Hr¨Î4DWáDäüHsÜ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DWÆDWá.DW¿Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÚ4Hr¨Î4DWDHrÅ’DWÆD¤ÄHs¸-ÄDWáDäüHsÜ|Phase 3A@..DW,DW¾12-15 YearsA YNN. DW¾DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091348100913481009DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¾.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÚ¬Hr¨Î¬DWDœÌHrÅ‘ÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DW¿BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÚ¬Hr¨Î¬DWDœÌHrÅ‘Ì......Phase 3A@..DW,DW¾12-15 YearsAYYNY. DW¾DWýDWýAàYEARSDSAC4591001C4591001 1009 10091348100913481009.DW,B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¾.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÚ¬Hr¨Î¬DWDœÌHrÅ‘ÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DW¿BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÚ¬Hr¨Î¬DWDœÌHrÅ‘Ì......Phase 3A@..DW,DW¾12-15 YearsAYYNY. DW¾DWýDWýAàYEARSDSA C4591001C4591001 1009 10091349100913491009DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÅDW+ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDúÈHr¨îÈDW¦DïÄHsŽHÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW’DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDúÈHr¨îÈDWDù`HrÅî`DW’DíäHssèäDW¦DïÄHsŽHÄPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1009 10091349100913491009.DW+B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÅDW+ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDúÈHr¨îÈDW¦DïÄHsŽHÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW’DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDúÈHr¨îÈDWDù`HrÅî`DW’DíäHssèäDW¦DïÄHsŽHÄPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1009 10091349100913491009DW’DW’B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÅDW+ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDúÈHr¨îÈDW¦DïÄHsŽHÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW’DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDúÈHr¨îÈDWDù`HrÅî`DW’DíäHssèäDW¦DïÄHsŽHÄPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1009 10091349100913491009.DWÅBÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÅDW+YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDúÈHr¨îÈDW¦DïÄHsŽHÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW’DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDúÈHr¨îÈDWDù`HrÅî`DW’DíäHssèäDW¦DïÄHsŽHÄPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1009 10091350100913501009DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÅ.DW+ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD™üHr©ß|DWàDê$HsÚº$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWËDWà.DWÆPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD™üHr©ß|DWD©°HrÆð0DWËDßÔHs¿TDWàDê$HsÚº$Phase 3A@..DW+DWÅ12-15 YearsA YNN. DWÅDWýDWýAàYEARSDSAC4591001C4591001 1009 10091350100913501009.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÅ.DW+ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD™üHr©ß|DWàDê$HsÚº$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWËDWà.DWÆPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD™üHr©ß|DWD©°HrÆð0DWËDßÔHs¿TDWàDê$HsÚº$Phase 3A@..DW+DWÅ12-15 YearsA YNN. DWÅDWýDWýAàYEARSDSA C4591001C4591001 1009 10091350100913501009DWËDWËBÓREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÅ.DW+ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD™üHr©ß|DWàDê$HsÚº$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWËDWà.DWÆPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD™üHr©ß|DWD©°HrÆð0DWËDßÔHs¿TDWàDê$HsÚº$Phase 3A@..DW+DWÅ12-15 YearsA YNN. DWÅDWýDWýAàYEARSDSA0C4591001C4591001 1009 10091351100913511009DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¶XHr©ûØDWDÃ´HrÅ¸´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW¾BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¶XHr©ûØDWDÃ´HrÅ¸´......Phase 3A@..DW*DW½12-15 YearsAYYNY. DW½DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091351100913511009.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¶XHr©ûØDWDÃ´HrÅ¸´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW¾BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¶XHr©ûØDWDÃ´HrÅ¸´......Phase 3A@..DW*DW½12-15 YearsAYYNY. DW½DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091353100913531009DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÊ.DW* AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD»DHrªÄDWDô8HrÅé8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD»DHrªÄDWDô8HrÅé8......Phase 3A@..DW*DWÊ12-15 YearsA YNY. DWý.DWýAÀYEARSDSAC4591001C4591001 1009 10091353100913531009.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÊ.DW* AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD»DHrªÄDWDô8HrÅé8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD»DHrªÄDWDô8HrÅé8......Phase 3A@..DW*DWÊ12-15 YearsA YNY. DWý.DWýAÀYEARSDSA C4591001C4591001 1009 10091354100913541009DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÅ.DW+ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÏlHrªìDWDTHrÆÓÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÏlHrªìDWDTHrÆÓÔ......Phase 3A@..DW+DWÅ12-15 YearsAYYNY. DW“DWýDWýAàYEARSDSAC4591001C4591001 1009 10091354100913541009.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÅ.DW+ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÏlHrªìDWDTHrÆÓÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÏlHrªìDWDTHrÆÓÔ......Phase 3A@..DW+DWÅ12-15 YearsAYYNY. DW“DWýDWýAàYEARSDSA C4591001C4591001 1009 10091355100913551009DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DWÆ.DW2 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDêœHrª0DWDàÄHrÈxÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWËBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDêœHrª0DWDàÄHrÈxÄ......Phase 3A@..DW2DWÆ12-15 YearsAYYNY. DWÊDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091355100913551009.DW2B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DWÆ.DW2 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDêœHrª0DWDàÄHrÈxÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWËBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDêœHrª0DWDàÄHrÈxÄ......Phase 3A@..DW2DWÆ12-15 YearsAYYNY. DWÊDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091356100913561009DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÆDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDõÜHrª;\DW¦DwÄHsÐÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDõÜHrª;\DWDõ HrÃG DW‘Dâ,Hsr‹¬DW¦DwÄHsÐÄPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091356100913561009.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÆDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDõÜHrª;\DW¦DwÄHsÐÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDõÜHrª;\DWDõ HrÃG DW‘Dâ,Hsr‹¬DW¦DwÄHsÐÄPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091356100913561009DW‘DW‘B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÆDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDõÜHrª;\DW¦DwÄHsÐÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDõÜHrª;\DWDõ HrÃG DW‘Dâ,Hsr‹¬DW¦DwÄHsÐÄPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091356100913561009.DWÆBÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÆDW1YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDõÜHrª;\DW¦DwÄHsÐÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDõÜHrª;\DWDõ HrÃG DW‘Dâ,Hsr‹¬DW¦DwÄHsÐÄPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091357100913571009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DW„DW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD–Hr«-DWgDŽøHs:ÙxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWSDWg.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD–Hr«-DW DèHrÄ3hDWSDÈdHs ´äDWgDŽøHs:ÙxPhase 3A@..DW).12-15 YearsA YNN. DW<DWýDWýAðYEARSDSAC4591001C4591001 1009 10091357100913571009.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW„DW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD–Hr«-DWgDŽøHs:ÙxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWSDWg.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD–Hr«-DW DèHrÄ3hDWSDÈdHs ´äDWgDŽøHs:ÙxPhase 3A@..DW).12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA C4591001C4591001 1009 10091357100913571009DWSDWSBZREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW„DW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD–Hr«-DWgDŽøHs:ÙxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWSDWg.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD–Hr«-DW DèHrÄ3hDWSDÈdHs ´äDWgDŽøHs:ÙxPhase 3A@..DW).12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091357100913571009.DW„B‹OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW„DW)YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD–Hr«-DWgDŽøHs:ÙxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWSDWg.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD–Hr«-DW DèHrÄ3hDWSDÈdHs ´äDWgDŽøHs:ÙxPhase 3A@..DW).12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091358100913581009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD•LHr«,LDWDØHrÅvØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD•LHr«,LDWDØHrÅvØ......Phase 3A@..DW,DWÄ12-15 YearsAYYNY. DW“DWýDWýAàYEARSDSAC4591001C4591001 1009 10091358100913581009.DW,B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD•LHr«,LDWDØHrÅvØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD•LHr«,LDWDØHrÅvØ......Phase 3A@..DW,DWÄ12-15 YearsAYYNY. DW“DWýDWýAàYEARSDSA C4591001C4591001 1009 10091359100913591009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD·HHr«NHDW¦DÁ\HsŽ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD·HHr«NHDWDÌ$HrÅÁ$DW‘D½ØHsrgXDW¦DÁ\HsŽ\Phase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091359100913591009.DW*B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD·HHr«NHDW¦DÁ\HsŽ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD·HHr«NHDWDÌ$HrÅÁ$DW‘D½ØHsrgXDW¦DÁ\HsŽ\Phase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091359100913591009DW‘DW‘B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD·HHr«NHDW¦DÁ\HsŽ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD·HHr«NHDWDÌ$HrÅÁ$DW‘D½ØHsrgXDW¦DÁ\HsŽ\Phase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091359100913591009.DWÅBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW*YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD·HHr«NHDW¦DÁ\HsŽ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD·HHr«NHDWDÌ$HrÅÁ$DW‘D½ØHsrgXDW¦DÁ\HsŽ\Phase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091360100913601009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÉ.DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD·üHr«NüDWDÌœHrÅÁœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŠBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD·üHr«NüDWDÌœHrÅÁœ......Phase 3A@..DW*DWÉ12-15 YearsAYYNY. DW‰DWýDWýAðYEARSDSAC4591001C4591001 1009 10091360100913601009.DW*B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÉ.DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD·üHr«NüDWDÌœHrÅÁœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŠBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD·üHr«NüDWDÌœHrÅÁœ......Phase 3A@..DW*DWÉ12-15 YearsAYYNY. DW‰DWýDWýAðYEARSDSA C4591001C4591001 1009 10091361100913611009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÐDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÇìHr«^ìDW¦D«HsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÇìHr«^ìDW DðxHrÄ“øDW‘DóHsrœŒDW¦D«HsŽPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091361100913611009.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÐDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÇìHr«^ìDW¦D«HsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÇìHr«^ìDW DðxHrÄ“øDW‘DóHsrœŒDW¦D«HsŽPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091361100913611009DW‘DW‘B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÐDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÇìHr«^ìDW¦D«HsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÇìHr«^ìDW DðxHrÄ“øDW‘DóHsrœŒDW¦D«HsŽPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091361100913611009.DWÐB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÐDW)YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÇìHr«^ìDW¦D«HsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÇìHr«^ìDW DðxHrÄ“øDW‘DóHsrœŒDW¦D«HsŽPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091362100913621009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÊ.DW/ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDåìHr«|ìDWDÝ@HrÌiÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWÐBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDåìHr«|ìDWDÝ@HrÌiÀ......Phase 3A@..DW/DWÊ12-15 YearsAYYNY. DWÏDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091362100913621009.DW/B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÊ.DW/ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDåìHr«|ìDWDÝ@HrÌiÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWÐBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDåìHr«|ìDWDÝ@HrÌiÀ......Phase 3A@..DW/DWÊ12-15 YearsAYYNY. DWÏDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091363100913631009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÐ.DW0 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDåtHr«|tDW÷DáðHsùpPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVú..DWÛDW÷.DWÑPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDåtHr«|tDVúDåtHr«|tDWÛDœHsÓÕDW÷DáðHsùpPhase 3A@.DWDW0DWÐ12-15 YearsA YNN. DWÐDWýDWýAàYEARSDSAC4591001C4591001 1009 10091363100913631009DWÛDWÛBâREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÐ.DW0 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDåtHr«|tDW÷DáðHsùpPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVú..DWÛDW÷.DWÑPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDåtHr«|tDVúDåtHr«|tDWÛDœHsÓÕDW÷DáðHsùpPhase 3A@.DWDW0DWÐ12-15 YearsA YNN. DWÐDWýDWýAàYEARSDSA C4591001C4591001 1009 10091363100913631009.DWA°VACCINATION BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABhas tested positive for COVID-19 DW0DWÐ.DW0 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDåtHr«|tDW÷DáðHsùpPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVú..DWÛDW÷.DWÑPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDåtHr«|tDVúDåtHr«|tDWÛDœHsÓÕDW÷DáðHsùpPhase 3A@.DWDW0DWÐ12-15 YearsA YNN. DWÐDWýDWýAàYEARSDSA`C4591001C4591001 1009 10091364100913641009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÑ.DW7 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDìHr«ƒDWD× HrÖð BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWÓBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDìHr«ƒDWD× HrÖð ......Phase 3A@..DW7DWÑ12-15 YearsAYYNY. DWÒDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091364100913641009.DW7B>VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÑ.DW7 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDìHr«ƒDWD× HrÖð BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWÓBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDìHr«ƒDWD× HrÖð ......Phase 3A@..DW7DWÑ12-15 YearsAYYNY. DWÒDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091365100913651009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDì¸Hr«ƒ¸DWïDàLHsîvÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWÑDWï.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDì¸Hr«ƒ¸DWDØHrÖð˜DWÑDÄ¤HsÆÎ$DWïDàLHsîvÌPhase 3A@..DW7.12-15 YearsA YNN. DW—DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091365100913651009.DW7B>VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDì¸Hr«ƒ¸DWïDàLHsîvÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWÑDWï.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDì¸Hr«ƒ¸DWDØHrÖð˜DWÑDÄ¤HsÆÎ$DWïDàLHsîvÌPhase 3A@..DW7.12-15 YearsA YNN. DW—DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091365100913651009DWÑDWÑBØREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDì¸Hr«ƒ¸DWïDàLHsîvÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWÑDWï.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDì¸Hr«ƒ¸DWDØHrÖð˜DWÑDÄ¤HsÆÎ$DWïDàLHsîvÌPhase 3A@..DW7.12-15 YearsA YNN. DW—DWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091366100913661009DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,..DW, AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDð<Hr«‡<DWúD|°Hsü“°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVú.DWADWæDWú.DWáPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDð<Hr«‡<DWADäHHs ÈDWæD€¬Hsâ9¬DWúD|°Hsü“°Phase 3A@..DW,.12-15 YearsA YNN. DWàDWýDWýAàYEARSDSAC4591001C4591001 1009 10091366100913661009.DW]BdVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,..DW, AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDð<Hr«‡<DWúD|°Hsü“°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVú.DWADWæDWú.DWáPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDð<Hr«‡<DWADäHHs ÈDWæD€¬Hsâ9¬DWúD|°Hsü“°Phase 3A@..DW,.12-15 YearsA YNN. DWàDWýDWýAàYEARSDSA C4591001C4591001 1009 10091366100913661009DWæDWæBíREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,..DW, AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDð<Hr«‡<DWúD|°Hsü“°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVú.DWADWæDWú.DWáPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDð<Hr«‡<DWADäHHs ÈDWæD€¬Hsâ9¬DWúD|°Hsü“°Phase 3A@..DW,.12-15 YearsA YNN. DWàDWýDWýAàYEARSDSA0C4591001C4591001 1009 10091369100913691009DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWËDW3 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDš°Hr¬ƒ0DW¨D‰Hs…Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDš°Hr¬ƒ0DWD„¨HrÈ¨DW•D‹°Hsw{0DW¨D‰Hs…Phase 3A@..DW3.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091369100913691009.DW3B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWËDW3 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDš°Hr¬ƒ0DW¨D‰Hs…Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDš°Hr¬ƒ0DWD„¨HrÈ¨DW•D‹°Hsw{0DW¨D‰Hs…Phase 3A@..DW3.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091369100913691009DW•DW•B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWËDW3 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDš°Hr¬ƒ0DW¨D‰Hs…Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDš°Hr¬ƒ0DWD„¨HrÈ¨DW•D‹°Hsw{0DW¨D‰Hs…Phase 3A@..DW3.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091369100913691009.DWËBÑOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWËDW3YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDš°Hr¬ƒ0DW¨D‰Hs…Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDš°Hr¬ƒ0DWD„¨HrÈ¨DW•D‹°Hsw{0DW¨D‰Hs…Phase 3A@..DW3.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1009 10091370100913701009DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD ŒHr¬‰DWD¶XHrÈNXBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW¿BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD ŒHr¬‰DWD¶XHrÈNX......Phase 3A@..DW,DW¿12-15 YearsA YNY. DW¾DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091370100913701009.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW¿.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD ŒHr¬‰DWD¶XHrÈNXBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW¿BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD ŒHr¬‰DWD¶XHrÈNX......Phase 3A@..DW,DW¿12-15 YearsA YNY. DW¾DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091371100913711009DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD¿ôHr¬¨tDWD©ìHrÈAìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD¿ôHr¬¨tDWD©ìHrÈAì......Phase 3A@..DW,DWÄ12-15 YearsA YNY. DWý.DWýAÐYEARSDSAC4591001C4591001 1009 10091371100913711009.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD¿ôHr¬¨tDWD©ìHrÈAìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD¿ôHr¬¨tDWD©ìHrÈAì......Phase 3A@..DW,DWÄ12-15 YearsA YNY. DWý.DWýAÐYEARSDSA C4591001C4591001 1009 10091372100913721009DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DW¿.DW2 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÕHHr¬½ÈDWDÈ(HrÈ`(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÕHHr¬½ÈDWDÈ(HrÈ`(......Phase 3A@..DW2DW¿12-15 YearsA YNY. DWý.DWýAÐYEARSDSAC4591001C4591001 1009 10091372100913721009.DW2B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DW¿.DW2 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÕHHr¬½ÈDWDÈ(HrÈ`(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÕHHr¬½ÈDWDÈ(HrÈ`(......Phase 3A@..DW2DW¿12-15 YearsA YNY. DWý.DWýAÐYEARSDSA C4591001C4591001 1009 10091373100913731009DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÌ.DW, AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDàLHr¬ÈÌDWâDÜPHsÝOPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWÍDWâ.DWÌPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDàLHr¬ÈÌDWDäÀHrÈ|ÀDWÍDâhHsÁ¥èDWâDÜPHsÝOPPhase 3A@..DW,DWÌ12-15 YearsA YNN. DWËDWýDWýAàYEARSDSAC4591001C4591001 1009 10091373100913731009.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÌ.DW, AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDàLHr¬ÈÌDWâDÜPHsÝOPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWÍDWâ.DWÌPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDàLHr¬ÈÌDWDäÀHrÈ|ÀDWÍDâhHsÁ¥èDWâDÜPHsÝOPPhase 3A@..DW,DWÌ12-15 YearsA YNN. DWËDWýDWýAàYEARSDSA C4591001C4591001 1009 10091373100913731009DWÍDWÍBÓREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÌ.DW, AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDàLHr¬ÈÌDWâDÜPHsÝOPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWÍDWâ.DWÌPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDàLHr¬ÈÌDWDäÀHrÈ|ÀDWÍDâhHsÁ¥èDWâDÜPHsÝOPPhase 3A@..DW,DWÌ12-15 YearsA YNN. DWËDWýDWýAàYEARSDSA0C4591001C4591001 1009 10091374100913741009DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÍDW/ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¨HHr°…HDWD°ôHs—DtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW˜DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¨HHr°…HDWDûHrÌ‡„DW˜DÔHs{¸DWD°ôHs—DtPhase 3A@..DW/.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSAC4591001C4591001 1009 10091374100913741009.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÍDW/ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¨HHr°…HDWD°ôHs—DtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW˜DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¨HHr°…HDWDûHrÌ‡„DW˜DÔHs{¸DWD°ôHs—DtPhase 3A@..DW/.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA C4591001C4591001 1009 10091374100913741009DW˜DW˜B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÍDW/ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¨HHr°…HDWD°ôHs—DtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW˜DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¨HHr°…HDWDûHrÌ‡„DW˜DÔHs{¸DWD°ôHs—DtPhase 3A@..DW/.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091374100913741009.DWÍBÐOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÍDW/YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¨HHr°…HDWD°ôHs—DtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW˜DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¨HHr°…HDWDûHrÌ‡„DW˜DÔHs{¸DWD°ôHs—DtPhase 3A@..DW/.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091375100913751009DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÉ.DW/ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¨ÀHr°…ÀDWDúŒHrÌ‡BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¨ÀHr°…ÀDWDúŒHrÌ‡......Phase 3A@..DW/DWÉ12-15 YearsA YNY. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091375100913751009.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÉ.DW/ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¨ÀHr°…ÀDWDúŒHrÌ‡BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¨ÀHr°…ÀDWDúŒHrÌ‡......Phase 3A@..DW/DWÉ12-15 YearsA YNY. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091376100913761009DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÄàHr°¡àDWDÝ¸HrÌj8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÄàHr°¡àDWDÝ¸HrÌj8......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091376100913761009.DW3B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÄàHr°¡àDWDÝ¸HrÌj8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÄàHr°¡àDWDÝ¸HrÌj8......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091377100913771009DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÞ¨Hr°»¨DWD’HrÍpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÞ¨Hr°»¨DWD’HrÍp......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091377100913771009.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÞ¨Hr°»¨DWD’HrÍpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÞ¨Hr°»¨DWD’HrÍp......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091378100913781009DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDß Hr°¼ DWîDëŒHsí0ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW×DWî.DWÒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDß Hr°¼ DWD‘ŒHrÍoŒDW×D¿|HsÎ±üDWîDëŒHsí0ŒPhase 3A@..DW6DWÉ12-15 YearsA YNN. DWÑDWýDWýAàYEARSDSAC4591001C4591001 1009 10091378100913781009.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDß Hr°¼ DWîDëŒHsí0ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW×DWî.DWÒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDß Hr°¼ DWD‘ŒHrÍoŒDW×D¿|HsÎ±üDWîDëŒHsí0ŒPhase 3A@..DW6DWÉ12-15 YearsA YNN. DWÑDWýDWýAàYEARSDSA C4591001C4591001 1009 10091378100913781009DW×DW×BÚREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDß Hr°¼ DWîDëŒHsí0ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW×DWî.DWÒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDß Hr°¼ DWD‘ŒHrÍoŒDW×D¿|HsÎ±üDWîDëŒHsí0ŒPhase 3A@..DW6DWÉ12-15 YearsA YNN. DWÑDWýDWýAàYEARSDSA0C4591001C4591001 1009 10091379100913791009DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÊDW6 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÉTHr±÷ÔDW¨D„lHs€lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÉTHr±÷ÔDWDzÐHrÏûÐDW“D¬HstÜ,DW¨D„lHs€lPhase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091379100913791009.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÊDW6 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÉTHr±÷ÔDW¨D„lHs€lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÉTHr±÷ÔDWDzÐHrÏûÐDW“D¬HstÜ,DW¨D„lHs€lPhase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091379100913791009DW“DW“B•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÊDW6 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÉTHr±÷ÔDW¨D„lHs€lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÉTHr±÷ÔDWDzÐHrÏûÐDW“D¬HstÜ,DW¨D„lHs€lPhase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091379100913791009.DWÊBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÊDW6YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDÉTHr±÷ÔDW¨D„lHs€lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDÉTHr±÷ÔDWDzÐHrÏûÐDW“D¬HstÜ,DW¨D„lHs€lPhase 3A@..DW6.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091380100913801009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWîDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèDHr»QDDWÉDµ¤Hs¼3$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW¶DWÉ.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèDHr»QDDWDÝ¸HrÖö8DW¶DºTHs£+TDWÉDµ¤Hs¼3$Phase 3A@..DW=.12-15 YearsA YNN. DW™DWýDWýAàYEARSDSAC4591001C4591001 1009 10091380100913801009.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWîDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèDHr»QDDWÉDµ¤Hs¼3$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW¶DWÉ.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèDHr»QDDWDÝ¸HrÖö8DW¶DºTHs£+TDWÉDµ¤Hs¼3$Phase 3A@..DW=.12-15 YearsA YNN. DW™DWýDWýAàYEARSDSA C4591001C4591001 1009 10091380100913801009DW¶DW¶B±REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWîDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèDHr»QDDWÉDµ¤Hs¼3$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW¶DWÉ.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèDHr»QDDWDÝ¸HrÖö8DW¶DºTHs£+TDWÉDµ¤Hs¼3$Phase 3A@..DW=.12-15 YearsA YNN. DW™DWýDWýAàYEARSDSA0C4591001C4591001 1009 10091380100913801009.DWîBéOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWîDW=YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèDHr»QDDWÉDµ¤Hs¼3$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW¶DWÉ.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèDHr»QDDWDÝ¸HrÖö8DW¶DºTHs£+TDWÉDµ¤Hs¼3$Phase 3A@..DW=.12-15 YearsA YNN. DW™DWýDWýAàYEARSDSA@C4591001C4591001 1009 10091381100913811009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÊ.DW7 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡@Hr½@DWDx´HrÖ‘4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡@Hr½@DWDx´HrÖ‘4......Phase 3A@..DW7DWÊ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091381100913811009.DW7B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÊ.DW7 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡@Hr½@DWDx´HrÖ‘4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡@Hr½@DWDx´HrÖ‘4......Phase 3A@..DW7DWÊ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091382100913821009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¿DW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèHrÃ:DW¡D‹8Hs‡L¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèHrÃ:DW!DäüHrÞæ|DWŽD€pHsn5pDW¡D‹8Hs‡L¸Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1009 10091382100913821009.DW@B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¿DW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèHrÃ:DW¡D‹8Hs‡L¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèHrÃ:DW!DäüHrÞæ|DWŽD€pHsn5pDW¡D‹8Hs‡L¸Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1009 10091382100913821009DWŽDWŽBƒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¿DW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèHrÃ:DW¡D‹8Hs‡L¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèHrÃ:DW!DäüHrÞæ|DWŽD€pHsn5pDW¡D‹8Hs‡L¸Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1009 10091382100913821009.DW¿B´OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¿DW@YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèHrÃ:DW¡D‹8Hs‡L¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèHrÃ:DW!DäüHrÞæ|DWŽD€pHsn5pDW¡D‹8Hs‡L¸Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1009 10091383100913831009DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÐ.DWD AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D¿ôHrÄctDW!D±0HrÞ²°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW!....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D¿ôHrÄctDW!D±0HrÞ²°......Phase 3A@DWá.DWDDWÐ12-15 YearsA YNY. DW<DWáDWáAðYEARSDSAC4591001C4591001 1009 10091383100913831009.DWDB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÐ.DWD AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D¿ôHrÄctDW!D±0HrÞ²°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW!....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D¿ôHrÄctDW!D±0HrÞ²°......Phase 3A@DWá.DWDDWÐ12-15 YearsA YNY. DW<DWáDWáAðYEARSDSA C4591001C4591001 1009 10091383100913831009.DWáBÕFOLLOW-UP BDISPOSITION EVENTOTHER ApParticipant enrolled in C4591031 DWDDWÐ.DWDYAðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D¿ôHrÄctDW!D±0HrÞ²°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW!....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D¿ôHrÄctDW!D±0HrÞ²°......Phase 3A@DWá.DWDDWÐ12-15 YearsA YNY. DW<DWáDWáAðYEARSDSA@C4591001C4591001 1009 10091384100913841009DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWvDW> AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW D¿|HrÄbüDWSDŽHs zˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DW>DWS.DW:Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D¿|HrÄbüDW!D°@HrÞ±ÀDW>D—,HsÔ,DWSDŽHs zˆPhase 3A@..DW>.12-15 YearsA YNN. DW9DWýDWýAðYEARSDSAC4591001C4591001 1009 10091384100913841009DW>DW>B2REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWvDW> AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW D¿|HrÄbüDWSDŽHs zˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DW>DWS.DW:Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D¿|HrÄbüDW!D°@HrÞ±ÀDW>D—,HsÔ,DWSDŽHs zˆPhase 3A@..DW>.12-15 YearsA YNN. DW9DWýDWýAðYEARSDSA C4591001C4591001 1009 10091384100913841009.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWvDW> AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW D¿|HrÄbüDWSDŽHs zˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DW>DWS.DW:Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D¿|HrÄbüDW!D°@HrÞ±ÀDW>D—,HsÔ,DWSDŽHs zˆPhase 3A@..DW>.12-15 YearsA YNN. DW9DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091384100913841009.DWvBjOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWvDW>YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW D¿|HrÄbüDWSDŽHs zˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DW>DWS.DW:Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D¿|HrÄbüDW!D°@HrÞ±ÀDW>D—,HsÔ,DWSDŽHs zˆPhase 3A@..DW>.12-15 YearsA YNN. DW9DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091385100913851009DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÆHrÄiŒDW®D´ðHs˜™ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW˜DW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÆHrÄiŒDW"Dß˜Hrà2˜DW˜DŸ`Hs{ƒ`DW®D´ðHs˜™ðPhase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSAC4591001C4591001 1009 10091385100913851009.DW?B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÆHrÄiŒDW®D´ðHs˜™ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW˜DW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÆHrÄiŒDW"Dß˜Hrà2˜DW˜DŸ`Hs{ƒ`DW®D´ðHs˜™ðPhase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA C4591001C4591001 1009 10091385100913851009DW˜DW˜BŒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÆHrÄiŒDW®D´ðHs˜™ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW˜DW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÆHrÄiŒDW"Dß˜Hrà2˜DW˜DŸ`Hs{ƒ`DW®D´ðHs˜™ðPhase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA0C4591001C4591001 1009 10091385100913851009.DWÊB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW?YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÆHrÄiŒDW®D´ðHs˜™ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW˜DW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÆHrÄiŒDW"Dß˜Hrà2˜DW˜DŸ`Hs{ƒ`DW®D´ðHs˜™ðPhase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA@C4591001C4591001 1009 10091386100913861009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÒ.DWA AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD² HrÅ§ DW!D‹8HrÞŒ¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD² HrÅ§ DW!D‹8HrÞŒ¸......Phase 3A@..DWADWÒ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1009 10091386100913861009.DWAB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÒ.DWA AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD² HrÅ§ DW!D‹8HrÞŒ¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD² HrÅ§ DW!D‹8HrÞŒ¸......Phase 3A@..DWADWÒ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1009 10091387100913871009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWÛ.DWH AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÇ°HrÅ¼°DW$DïLHrâåLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÇ°HrÅ¼°DW$DïLHrâåL......Phase 3A@..DWHDWÛ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091387100913871009.DWHB;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWÛ.DWH AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÇ°HrÅ¼°DW$DïLHrâåLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÇ°HrÅ¼°DW$DïLHrâåL......Phase 3A@..DWHDWÛ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091388100913881009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÉDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæÜHrÅÛÜDW¦D·HHsŽHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW¦.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæÜHrÅÛÜDW$DßÔHrâÕÔDW“D·üHsu|DW¦D·HHsŽHPhase 3A@..DW@.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091388100913881009.DW@B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÉDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæÜHrÅÛÜDW¦D·HHsŽHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW¦.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæÜHrÅÛÜDW$DßÔHrâÕÔDW“D·üHsu|DW¦D·HHsŽHPhase 3A@..DW@.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091388100913881009DW“DW“B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÉDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæÜHrÅÛÜDW¦D·HHsŽHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW¦.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæÜHrÅÛÜDW$DßÔHrâÕÔDW“D·üHsu|DW¦D·HHsŽHPhase 3A@..DW@.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091388100913881009.DWÉB¼OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÉDW@YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæÜHrÅÛÜDW¦D·HHsŽHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW¦.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæÜHrÅÛÜDW$DßÔHrâÕÔDW“D·üHsu|DW¦D·HHsŽHPhase 3A@..DW@.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091389100913891009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÙ.DW@ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDílHrÅâlDW!Dñ¤HrÞó$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDílHrÅâlDW!Dñ¤HrÞó$......Phase 3A@..DW@DWÙ12-15 YearsA YNY. DW<DWýDWýAðYEARSDSAC4591001C4591001 1009 10091389100913891009.DW@B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÙ.DW@ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDílHrÅâlDW!Dñ¤HrÞó$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDílHrÅâlDW!Dñ¤HrÞó$......Phase 3A@..DW@DWÙ12-15 YearsA YNY. DW<DWýDWýAðYEARSDSA C4591001C4591001 1009 10091390100913901009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWØ.DWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD·HHrÆýÈDWóDíäHsóÊdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWÞDWó.DWÙPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD·HHrÆýÈDW$D|8Hrâr8DWÞDª(Hs××(DWóDíäHsóÊdPhase 3A@..DWADWØ12-15 YearsA YNN. DWØDWýDWýAàYEARSDSAC4591001C4591001 1009 10091390100913901009.DWAB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWØ.DWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD·HHrÆýÈDWóDíäHsóÊdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWÞDWó.DWÙPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD·HHrÆýÈDW$D|8Hrâr8DWÞDª(Hs××(DWóDíäHsóÊdPhase 3A@..DWADWØ12-15 YearsA YNN. DWØDWýDWýAàYEARSDSA C4591001C4591001 1009 10091390100913901009DWÞDWÞBÐREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWADWØ.DWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD·HHrÆýÈDWóDíäHsóÊdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWÞDWó.DWÙPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD·HHrÆýÈDW$D|8Hrâr8DWÞDª(Hs××(DWóDíäHsóÊdPhase 3A@..DWADWØ12-15 YearsA YNN. DWØDWýDWýAàYEARSDSA0C4591001C4591001 1009 10091391100913911009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÞ.DWD AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌØHrÇXDW%D¹(Hrä¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌØHrÇXDW%D¹(Hrä¨......Phase 3A@..DWDDWÞ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1009 10091391100913911009.DWDB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÞ.DWD AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌØHrÇXDW%D¹(Hrä¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌØHrÇXDW%D¹(Hrä¨......Phase 3A@..DWDDWÞ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1009 10091392100913921009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWïDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÍPHrÇÐDWÓD·ÀHsÉd@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW¾DWÓ.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍPHrÇÐDW%D¹ Hrä DW¾D‡ðHs„ðDWÓD·ÀHsÉd@Phase 3A@..DWD.12-15 YearsA YNN. DW¼DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091392100913921009.DWDB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWïDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÍPHrÇÐDWÓD·ÀHsÉd@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW¾DWÓ.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍPHrÇÐDW%D¹ Hrä DW¾D‡ðHs„ðDWÓD·ÀHsÉd@Phase 3A@..DWD.12-15 YearsA YNN. DW¼DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091392100913921009DW¾DW¾B°REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWïDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÍPHrÇÐDWÓD·ÀHsÉd@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW¾DWÓ.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍPHrÇÐDW%D¹ Hrä DW¾D‡ðHs„ðDWÓD·ÀHsÉd@Phase 3A@..DWD.12-15 YearsA YNN. DW¼DWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091392100913921009.DWïBáOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWïDWDYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÍPHrÇÐDWÓD·ÀHsÉd@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW¾DWÓ.DW½Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍPHrÇÐDW%D¹ Hrä DW¾D‡ðHs„ðDWÓD·ÀHsÉd@Phase 3A@..DWD.12-15 YearsA YNN. DW¼DWýDWýAÀYEARSDSA@C4591001C4591001 1009 10091393100913931009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWØ.DWD AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDËèHrÇhDW#D´´HráY4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDËèHrÇhDW#D´´HráY4......Phase 3A@..DWDDWØ12-15 YearsA YNY. DW“DWýDWýAàYEARSDSAC4591001C4591001 1009 10091393100913931009.DWDB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWØ.DWD AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDËèHrÇhDW#D´´HráY4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDËèHrÇhDW#D´´HráY4......Phase 3A@..DWDDWØ12-15 YearsA YNY. DW“DWýDWýAàYEARSDSA C4591001C4591001 1009 10091394100913941009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWà.DWD AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÝ¸HrÇ$8DW#DÅHráiœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÝ¸HrÇ$8DW#DÅHráiœ......Phase 3A@..DWDDWà12-15 YearsA YNY. DW”DWýDWýAðYEARSDSAC4591001C4591001 1009 10091394100913941009.DWDB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWà.DWD AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÝ¸HrÇ$8DW#DÅHráiœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÝ¸HrÇ$8DW#DÅHráiœ......Phase 3A@..DWDDWà12-15 YearsA YNY. DW”DWýDWýAðYEARSDSA C4591001C4591001 1009 10091395100913951009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÍDWD AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÝHrÇ#„DWDštHs—-ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWšDW.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÝHrÇ#„DW#DÅ”HrájDWšDÌ$Hs~S$DWDštHs—-ôPhase 3A@..DWD.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSAC4591001C4591001 1009 10091395100913951009.DWDB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÍDWD AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÝHrÇ#„DWDštHs—-ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWšDW.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÝHrÇ#„DW#DÅ”HrájDWšDÌ$Hs~S$DWDštHs—-ôPhase 3A@..DWD.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA C4591001C4591001 1009 10091395100913951009DWšDWšBŒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÍDWD AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÝHrÇ#„DWDštHs—-ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWšDW.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÝHrÇ#„DW#DÅ”HrájDWšDÌ$Hs~S$DWDštHs—-ôPhase 3A@..DWD.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA0C4591001C4591001 1009 10091395100913951009.DWÍB¿OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÍDWDYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÝHrÇ#„DWDštHs—-ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWšDW.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÝHrÇ#„DW#DÅ”HrájDWšDÌ$Hs~S$DWDštHs—-ôPhase 3A@..DWD.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA@C4591001C4591001 1009 10091396100913961009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWç.DW@ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèHrÇ.ˆDW"DáHrà4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWvBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèHrÇ.ˆDW"DáHrà4......Phase 3A@..DW@DWç12-15 YearsA YNY. DWuDWýDWýAðYEARSDSAC4591001C4591001 1009 10091396100913961009.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWç.DW@ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèHrÇ.ˆDW"DáHrà4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWvBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèHrÇ.ˆDW"DáHrà4......Phase 3A@..DW@DWç12-15 YearsA YNY. DWuDWýDWýAðYEARSDSA C4591001C4591001 1009 10091398100913981009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDøèHrÇ?hDW$DóüHrâéüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DW\BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDøèHrÇ?hDW$DóüHrâéü......Phase 3A@..DWADWÞ12-15 YearsA YNY. DW[DWýDWýAðYEARSDSAC4591001C4591001 1009 10091398100913981009.DWAB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDøèHrÇ?hDW$DóüHrâéüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DW\BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDøèHrÇ?hDW$DóüHrâéü......Phase 3A@..DWADWÞ12-15 YearsA YNY. DW[DWýDWýAðYEARSDSA C4591001C4591001 1009 10091399100913991009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÚ.DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¨ÀHrÈ@ÀDWðDçHsïÏPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWÛDWð.DWÚPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨ÀHrÈ@ÀDW%D¡Hrãè„DWÛD¯PHsÓçÐDWðDçHsïÏPhase 3A@..DWADWÚ12-15 YearsA YNN. DWÙDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091399100913991009.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÚ.DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¨ÀHrÈ@ÀDWðDçHsïÏPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWÛDWð.DWÚPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨ÀHrÈ@ÀDW%D¡Hrãè„DWÛD¯PHsÓçÐDWðDçHsïÏPhase 3A@..DWADWÚ12-15 YearsA YNN. DWÙDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091399100913991009DWÛDWÛBÌREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÚ.DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¨ÀHrÈ@ÀDWðDçHsïÏPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWÛDWð.DWÚPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨ÀHrÈ@ÀDW%D¡Hrãè„DWÛD¯PHsÓçÐDWðDçHsïÏPhase 3A@..DWADWÚ12-15 YearsA YNN. DWÙDWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091400100914001009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWODWâ.DWO AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½`HrÈU`DWúDéèHsýèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW3.DWú..DWçPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½`HrÈU`DW3DŠÀHröG@DWúDéèHsýèDWúDéèHsýèPhase 3A@..DWODWâ12-15 YearsA YNN. DWæDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091400100914001009.DWOB@VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWODWâ.DWO AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½`HrÈU`DWúDéèHsýèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW3.DWú..DWçPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½`HrÈU`DW3DŠÀHröG@DWúDéèHsýèDWúDéèHsýèPhase 3A@..DWODWâ12-15 YearsA YNN. DWæDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091400100914001009DWúDWúBëREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWODWâ.DWO AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½`HrÈU`DWúDéèHsýèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW3.DWú..DWçPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½`HrÈU`DW3DŠÀHröG@DWúDéèHsýèDWúDéèHsýèPhase 3A@..DWODWâ12-15 YearsA YNN. DWæDWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091401100914011009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐ˜HrÈh˜DWóDæ(HsóÂ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWÞDWó.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐ˜HrÈh˜DW%Dß Hrä& DWÞD¸8Hs×å8DWóDæ(HsóÂ¨Phase 3A@..DWADW×12-15 YearsA YNN. DW×DWýDWýAÀYEARSDSAC4591001C4591001 1009 10091401100914011009.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐ˜HrÈh˜DWóDæ(HsóÂ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWÞDWó.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐ˜HrÈh˜DW%Dß Hrä& DWÞD¸8Hs×å8DWóDæ(HsóÂ¨Phase 3A@..DWADW×12-15 YearsA YNN. DW×DWýDWýAÀYEARSDSA C4591001C4591001 1009 10091401100914011009DWÞDWÞBÏREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÐ˜HrÈh˜DWóDæ(HsóÂ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWÞDWó.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÐ˜HrÈh˜DW%Dß Hrä& DWÞD¸8Hs×å8DWóDæ(HsóÂ¨Phase 3A@..DWADW×12-15 YearsA YNN. DW×DWýDWýAÀYEARSDSA0C4591001C4591001 1009 10091402100914021009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÐ HrÈh DW%DßÔHrä'TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWØBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÐ HrÈh DW%DßÔHrä'T......Phase 3A@..DWADW×12-15 YearsA YNY. DW×DWýDWýAàYEARSDSAC4591001C4591001 1009 10091402100914021009.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÐ HrÈh DW%DßÔHrä'TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWØBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÐ HrÈh DW%DßÔHrä'T......Phase 3A@..DWADW×12-15 YearsA YNY. DW×DWýDWýAàYEARSDSA C4591001C4591001 1009 10091403100914031009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWuDW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜŒHrÈtŒDWVDÃ<Hs$¤<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW?DWV.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜŒHrÈtŒDW#DƒHrá'„DW?Dâ¤Hsq$DWVDÃ<Hs$¤<Phase 3A@..DW?.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSAC4591001C4591001 1009 10091403100914031009DW?DW?B0REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWuDW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜŒHrÈtŒDWVDÃ<Hs$¤<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW?DWV.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜŒHrÈtŒDW#DƒHrá'„DW?Dâ¤Hsq$DWVDÃ<Hs$¤<Phase 3A@..DW?.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA C4591001C4591001 1009 10091403100914031009.DW?B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWuDW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜŒHrÈtŒDWVDÃ<Hs$¤<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW?DWV.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜŒHrÈtŒDW#DƒHrá'„DW?Dâ¤Hsq$DWVDÃ<Hs$¤<Phase 3A@..DW?.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091403100914031009.DWuBfOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWuDW?YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜŒHrÈtŒDWVDÃ<Hs$¤<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW?DWV.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜŒHrÈtŒDW#DƒHrá'„DW?Dâ¤Hsq$DWVDÃ<Hs$¤<Phase 3A@..DW?.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091404100914041009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWØ.DWA AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDì|HrÈ„|DW%D†LHrãÍÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDì|HrÈ„|DW%D†LHrãÍÌ......Phase 3A@..DWADWØ12-15 YearsA YNY. DWý.DWýAÀYEARSDSAC4591001C4591001 1009 10091404100914041009.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWØ.DWA AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDì|HrÈ„|DW%D†LHrãÍÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDì|HrÈ„|DW%D†LHrãÍÌ......Phase 3A@..DWADWØ12-15 YearsA YNY. DWý.DWýAÀYEARSDSA C4591001C4591001 1009 10091405100914051009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWEHrÈ˜àDWïDäHsîzŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWÙDWï.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWEHrÈ˜àDW%D‚ŒHrãÊDWÙD¬HsÑC,DWïDäHsîzŒPhase 3A@..DWADW×12-15 YearsA YNN. DW×DWýDWýAðYEARSDSAC4591001C4591001 1009 10091405100914051009.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWEHrÈ˜àDWïDäHsîzŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWÙDWï.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWEHrÈ˜àDW%D‚ŒHrãÊDWÙD¬HsÑC,DWïDäHsîzŒPhase 3A@..DWADW×12-15 YearsA YNN. DW×DWýDWýAðYEARSDSA C4591001C4591001 1009 10091405100914051009DWÙDWÙBÊREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWEHrÈ˜àDWïDäHsîzŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWÙDWï.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWEHrÈ˜àDW%D‚ŒHrãÊDWÙD¬HsÑC,DWïDäHsîzŒPhase 3A@..DWADW×12-15 YearsA YNN. DW×DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091406100914061009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWE€HrÈ˜hDWïDãÐHsîzPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWØDWï.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWE€HrÈ˜hDW%D‚PHrãÉÐDWØD¹dHsÏýdDWïDãÐHsîzPPhase 3A@..DWADW×12-15 YearsA YNN. DW×DWýDWýAðYEARSDSAC4591001C4591001 1009 10091406100914061009.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWE€HrÈ˜hDWïDãÐHsîzPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWØDWï.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWE€HrÈ˜hDW%D‚PHrãÉÐDWØD¹dHsÏýdDWïDãÐHsîzPPhase 3A@..DWADW×12-15 YearsA YNN. DW×DWýDWýAðYEARSDSA C4591001C4591001 1009 10091406100914061009DWØDWØBÉREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWE€HrÈ˜hDWïDãÐHsîzPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWØDWï.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWE€HrÈ˜hDW%D‚PHrãÉÐDWØD¹dHsÏýdDWïDãÐHsîzPPhase 3A@..DWADW×12-15 YearsA YNN. DW×DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091407100914071009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWà.DWD AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDµ¤HrÌB$DW(D«THrççTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDµ¤HrÌB$DW(D«THrççT......Phase 3A@..DWDDWà12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091407100914071009.DWDB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWà.DWD AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDµ¤HrÌB$DW(D«THrççTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDµ¤HrÌB$DW(D«THrççT......Phase 3A@..DWDDWà12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091408100914081009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWâ.DWH AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD÷øHrÌ„xDW)DöTHréƒÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWçBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD÷øHrÌ„xDW)DöTHréƒÔ......Phase 3A@..DWHDWâ12-15 YearsA YNY. DWæDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091408100914081009.DWHB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWâ.DWH AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD÷øHrÌ„xDW)DöTHréƒÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWçBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD÷øHrÌ„xDW)DöTHréƒÔ......Phase 3A@..DWHDWâ12-15 YearsA YNY. DWæDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091409100914091009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWâ.DWH AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD÷€HrÌ„DW)DõÜHréƒ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWçBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD÷€HrÌ„DW)DõÜHréƒ\......Phase 3A@..DWHDWâ12-15 YearsA YNY. DWæDWýDWýAàYEARSDSAC4591001C4591001 1009 10091409100914091009.DWHB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWâ.DWH AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD÷€HrÌ„DW)DõÜHréƒ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWçBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD÷€HrÌ„DW)DõÜHréƒ\......Phase 3A@..DWHDWâ12-15 YearsA YNY. DWæDWýDWýAàYEARSDSA C4591001C4591001 1009 10091410100914101009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‰ÐHrÍgÐDW(DêØHrè&ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‰ÐHrÍgÐDW(DêØHrè&Ø......Phase 3A@..DWDDW×12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1009 10091410100914101009.DWDB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‰ÐHrÍgÐDW(DêØHrè&ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‰ÐHrÍgÐDW(DêØHrè&Ø......Phase 3A@..DWDDW×12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1009 10091411100914111009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÊDWH AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•LHrÍsLDW§DœHsGPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW”DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD•LHrÍsLDW(D× Hrè DW”D¢äHsv@äDW§DœHsGPhase 3A@..DWH.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSAC4591001C4591001 1009 10091411100914111009.DWHB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÊDWH AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•LHrÍsLDW§DœHsGPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW”DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD•LHrÍsLDW(D× Hrè DW”D¢äHsv@äDW§DœHsGPhase 3A@..DWH.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA C4591001C4591001 1009 10091411100914111009DW”DW”BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÊDWH AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•LHrÍsLDW§DœHsGPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW”DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD•LHrÍsLDW(D× Hrè DW”D¢äHsv@äDW§DœHsGPhase 3A@..DWH.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091411100914111009.DWÊB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÊDWHYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•LHrÍsLDW§DœHsGPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW”DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD•LHrÍsLDW(D× Hrè DW”D¢äHsv@äDW§DœHsGPhase 3A@..DWH.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA@C4591001C4591001 1009 10091412100914121009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWRDW×.DWR AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙ¼HrÍ·¼DWðDÔHsï¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWÛDWð.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙ¼HrÍ·¼DW(D†LHrçÂLDWÛD×(HsÔ¨DWðDÔHsï¼Phase 3A@..DWRDW×12-15 YearsA YNN. DW×DWýDWýAðYEARSDSAC4591001C4591001 1009 10091412100914121009.DWRB?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWRDW×.DWR AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙ¼HrÍ·¼DWðDÔHsï¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWÛDWð.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙ¼HrÍ·¼DW(D†LHrçÂLDWÛD×(HsÔ¨DWðDÔHsï¼Phase 3A@..DWRDW×12-15 YearsA YNN. DW×DWýDWýAðYEARSDSA C4591001C4591001 1009 10091412100914121009DWÛDWÛBÈREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWRDW×.DWR AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙ¼HrÍ·¼DWðDÔHsï¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWÛDWð.DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙ¼HrÍ·¼DW(D†LHrçÂLDWÛD×(HsÔ¨DWðDÔHsï¼Phase 3A@..DWRDW×12-15 YearsA YNN. DW×DWýDWýAðYEARSDSA0C4591001C4591001 1009 10091413100914131009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWå.DWH AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÞ¨HrÍ¼¨DW*Då°HrêÄ°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÞ¨HrÍ¼¨DW*Då°HrêÄ°......Phase 3A@..DWHDWå12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1009 10091413100914131009.DWHB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWå.DWH AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÞ¨HrÍ¼¨DW*Då°HrêÄ°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÞ¨HrÍ¼¨DW*Då°HrêÄ°......Phase 3A@..DWHDWå12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1009 10091414100914141009DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWÚ.DWH AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDîÔHrÍÌÔDW+Dè¼Hrì<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW+....DWÞBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDîÔHrÍÌÔDW+Dè¼Hrì<......Phase 3A@..DWHDWÚ12-15 YearsA YNY. DWÝDWýDWýAàYEARSDSAC4591001C4591001 1009 10091414100914141009.DWHB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWÚ.DWH AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDîÔHrÍÌÔDW+Dè¼Hrì<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW+....DWÞBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDîÔHrÍÌÔDW+Dè¼Hrì<......Phase 3A@..DWHDWÚ12-15 YearsA YNY. DWÝDWýDWýAàYEARSDSA C4591001C4591001 1013 10131821101318211013DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD½`Hr”êàDVþDÝ|Hr°º|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD½`Hr”êàDVþDÝ|Hr°º|......Phase 3A@..DWDW´12-15 YearsA YNY. DW³DWýDWýAàYEARSDSAC4591001C4591001 1013 10131821101318211013.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD½`Hr”êàDVþDÝ|Hr°º|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD½`Hr”êàDVþDÝ|Hr°º|......Phase 3A@..DWDW´12-15 YearsA YNY. DW³DWýDWýAàYEARSDSA C4591001C4591001 1013 10131822101318221013DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD¼¬Hr”ê,DVþDÜÈHr°¹ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD¼¬Hr”ê,DVþDÜÈHr°¹È......Phase 3A@..DWDW´12-15 YearsAYYNY. DW³DWýDWýAðYEARSDSAC4591001C4591001 1013 10131822101318221013.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD¼¬Hr”ê,DVþDÜÈHr°¹ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW´BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD¼¬Hr”ê,DVþDÜÈHr°¹È......Phase 3A@..DWDW´12-15 YearsAYYNY. DW³DWýDWýAðYEARSDSA C4591001C4591001 1013 10131823101318231013DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¶DWæDW AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVêD·üHr–6üDWÊDãXHs½²XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW¶DWÊ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD·üHr–6üDVÿDÐ Hr±þ DW¶DŠ„Hs¢û„DWÊDãXHs½²XPhase 3A@..DWDW¶12-15 YearsA YNN. DW’DWýDWýAðYEARSDSAC4591001C4591001 1013 10131823101318231013.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¶DWæDW AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVêD·üHr–6üDWÊDãXHs½²XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW¶DWÊ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD·üHr–6üDVÿDÐ Hr±þ DW¶DŠ„Hs¢û„DWÊDãXHs½²XPhase 3A@..DWDW¶12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA C4591001C4591001 1013 10131823101318231013DW¶DW¶BÍREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¶DWæDW AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVêD·üHr–6üDWÊDãXHs½²XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW¶DWÊ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD·üHr–6üDVÿDÐ Hr±þ DW¶DŠ„Hs¢û„DWÊDãXHs½²XPhase 3A@..DWDW¶12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA0C4591001C4591001 1013 10131823101318231013.DWæBýOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¶DWæDWYAðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVêD·üHr–6üDWÊDãXHs½²XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW¶DWÊ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD·üHr–6üDVÿDÐ Hr±þ DW¶DŠ„Hs¢û„DWÊDãXHs½²XPhase 3A@..DWDW¶12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA@C4591001C4591001 1013 10131824101318241013DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêD¸°Hr–7°DVÿDÐ˜Hr±ÿBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêD¸°Hr–7°DVÿDÐ˜Hr±ÿ......Phase 3A@..DWDWµ12-15 YearsA YNY. DW’DWýDWýAàYEARSDSAC4591001C4591001 1013 10131824101318241013.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêD¸°Hr–7°DVÿDÐ˜Hr±ÿBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêD¸°Hr–7°DVÿDÐ˜Hr±ÿ......Phase 3A@..DWDWµ12-15 YearsA YNY. DW’DWýDWýAàYEARSDSA C4591001C4591001 1013 10131826101318261013DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDçÌHr–fÌDW´DÜÈHs ªÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DW¡DW´.DW Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDçÌHr–fÌDWDé4Hr³i4DW¡D‡ðHs‡IpDW´DÜÈHs ªÈPhase 3A@..DW.12-15 YearsA YNN. DWŸDWýDWýAàYEARSDSAC4591001C4591001 1013 10131826101318261013.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDçÌHr–fÌDW´DÜÈHs ªÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DW¡DW´.DW Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDçÌHr–fÌDWDé4Hr³i4DW¡D‡ðHs‡IpDW´DÜÈHs ªÈPhase 3A@..DW.12-15 YearsA YNN. DWŸDWýDWýAàYEARSDSA C4591001C4591001 1013 10131826101318261013DW¡DW¡B¸REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDçÌHr–fÌDW´DÜÈHs ªÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DW¡DW´.DW Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDçÌHr–fÌDWDé4Hr³i4DW¡D‡ðHs‡IpDW´DÜÈHs ªÈPhase 3A@..DW.12-15 YearsA YNN. DWŸDWýDWýAàYEARSDSA0C4591001C4591001 1013 10131826101318261013.DWÐBçOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDWYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDçÌHr–fÌDW´DÜÈHs ªÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DW¡DW´.DW Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDçÌHr–fÌDWDé4Hr³i4DW¡D‡ðHs‡IpDW´DÜÈHs ªÈPhase 3A@..DW.12-15 YearsA YNN. DWŸDWýDWýAàYEARSDSA@C4591001C4591001 1013 10131828101318281013DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¨.DW$ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD” Hr—d DWDÕHHr¼ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD” Hr—d DWDÕHHr¼È......Phase 3A@..DW$DW¨12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1013 10131828101318281013.DW$B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¨.DW$ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD” Hr—d DWDÕHHr¼ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD” Hr—d DWDÕHHr¼È......Phase 3A@..DW$DW¨12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1013 10131830101318301013DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëD–xHr—føDWD× Hr³W Placebo Placebo 12-15 YearsA . . .DVëDW.....Placebo Placebo Placebo A .Placebo A .DVëD–xHr—føDWD× Hr³W ......Phase 3A@DWŒ.DW.12-15 YearsA YNN. DWŒ.DWŒAàYEARSDSAC4591001C4591001 1013 10131830101318301013.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëD–xHr—føDWD× Hr³W Placebo Placebo 12-15 YearsA . . .DVëDW.....Placebo Placebo Placebo A .Placebo A .DVëD–xHr—føDWD× Hr³W ......Phase 3A@DWŒ.DW.12-15 YearsA YNN. DWŒ.DWŒAàYEARSDSA C4591001C4591001 1013 10131830101318301013.DWŒB¢FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BWanted to get vaccine closer to home and now able to do so. DW..DWYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëD–xHr—føDWD× Hr³W Placebo Placebo 12-15 YearsA . . .DVëDW.....Placebo Placebo Placebo A .Placebo A .DVëD–xHr—føDWD× Hr³W ......Phase 3A@DWŒ.DW.12-15 YearsA YNN. DWŒ.DWŒAàYEARSDSA`C4591001C4591001 1013 10131835101318351013DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëD² Hr—‚ DW®DÈ(Hs˜(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DWšDW®.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëD² Hr—‚ DVÿDÈdHr±öäDWšDëŒHs~rŒDW®DÈ(Hs˜(Phase 3A@..DW.12-15 YearsA YNN. DW“DWýDWýAàYEARSDSAC4591001C4591001 1013 10131835101318351013.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëD² Hr—‚ DW®DÈ(Hs˜(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DWšDW®.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëD² Hr—‚ DVÿDÈdHr±öäDWšDëŒHs~rŒDW®DÈ(Hs˜(Phase 3A@..DW.12-15 YearsA YNN. DW“DWýDWýAàYEARSDSA C4591001C4591001 1013 10131835101318351013DWšDWšB°REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëD² Hr—‚ DW®DÈ(Hs˜(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DWšDW®.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëD² Hr—‚ DVÿDÈdHr±öäDWšDëŒHs~rŒDW®DÈ(Hs˜(Phase 3A@..DW.12-15 YearsA YNN. DW“DWýDWýAàYEARSDSA0C4591001C4591001 1013 10131835101318351013.DWÐBæOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDWYAàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëD² Hr—‚ DW®DÈ(Hs˜(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DWšDW®.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëD² Hr—‚ DVÿDÈdHr±öäDWšDëŒHs~rŒDW®DÈ(Hs˜(Phase 3A@..DW.12-15 YearsA YNN. DW“DWýDWýAàYEARSDSA@C4591001C4591001 1013 10131836101318361013DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD²˜Hr—ƒDVÿDÈÜHr±÷\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD²˜Hr—ƒDVÿDÈÜHr±÷\......Phase 3A@..DWDW®12-15 YearsAYYNY. DW“DWýDWýAÀYEARSDSAC4591001C4591001 1013 10131836101318361013.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD²˜Hr—ƒDVÿDÈÜHr±÷\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD²˜Hr—ƒDVÿDÈÜHr±÷\......Phase 3A@..DWDW®12-15 YearsAYYNY. DW“DWýDWýAÀYEARSDSA C4591001C4591001 1013 10131839101318391013DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDWË.DW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDºTHr—ŠÔDWDÐ Hr³P Placebo Placebo 12-15 YearsA . . .DVëDW....DW¾Placebo Placebo Placebo A .Placebo A .DVëDºTHr—ŠÔDWDÐ Hr³P ......Phase 3A@..DWDWË12-15 YearsA YNN. DW½DWýDWýAàYEARSDSAC4591001C4591001 1013 10131839101318391013.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDWË.DW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDºTHr—ŠÔDWDÐ Hr³P Placebo Placebo 12-15 YearsA . . .DVëDW....DW¾Placebo Placebo Placebo A .Placebo A .DVëDºTHr—ŠÔDWDÐ Hr³P ......Phase 3A@..DWDWË12-15 YearsA YNN. DW½DWýDWýAàYEARSDSA C4591001C4591001 1013 10131841101318411013DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDì¸Hr—½8DVÿDÚ4Hr²´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDì¸Hr—½8DVÿDÚ4Hr²´......Phase 3A@..DWDW°12-15 YearsAYYNY. DW¯DWýDWýAÐYEARSDSAC4591001C4591001 1013 10131841101318411013.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDì¸Hr—½8DVÿDÚ4Hr²´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDì¸Hr—½8DVÿDÚ4Hr²´......Phase 3A@..DWDW°12-15 YearsAYYNY. DW¯DWýDWýAÐYEARSDSA C4591001C4591001 1013 10131842101318421013DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëDí0Hr—½°DWÑDáHsÆê€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW°DWÑ.DW°Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDí0Hr—½°DVÿDØÌHr²LDW°Dß˜Hs›g˜DWÑDáHsÆê€Phase 3A@..DW.12-15 YearsA YNN. DW¯DWýDWýAðYEARSDSAC4591001C4591001 1013 10131842101318421013.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëDí0Hr—½°DWÑDáHsÆê€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW°DWÑ.DW°Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDí0Hr—½°DVÿDØÌHr²LDW°Dß˜Hs›g˜DWÑDáHsÆê€Phase 3A@..DW.12-15 YearsA YNN. DW¯DWýDWýAðYEARSDSA C4591001C4591001 1013 10131842101318421013DW°DW°BÆREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëDí0Hr—½°DWÑDáHsÆê€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW°DWÑ.DW°Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDí0Hr—½°DVÿDØÌHr²LDW°Dß˜Hs›g˜DWÑDáHsÆê€Phase 3A@..DW.12-15 YearsA YNN. DW¯DWýDWýAðYEARSDSA0C4591001C4591001 1013 10131843101318431013DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DWÌ.DW# AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDïˆHr—ÀDVÿDâ,Hr²¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDïˆHr—ÀDVÿDâ,Hr²¬......Phase 3A@..DW#DWÌ12-15 YearsAYYNY. DW’DWýDWýAàYEARSDSAC4591001C4591001 1013 10131843101318431013.DW#B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWÌ.DW# AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDïˆHr—ÀDVÿDâ,Hr²¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDïˆHr—ÀDVÿDâ,Hr²¬......Phase 3A@..DW#DWÌ12-15 YearsAYYNY. DW’DWýDWýAàYEARSDSA C4591001C4591001 1013 10131844101318441013DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWìDW# AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëDïHr—¿DWÌDêØHsÀ\ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW·DWÌ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDïHr—¿DVÿDâàHr²`DW·DìHs¤®„DWÌDêØHsÀ\ØPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1013 10131844101318441013.DW#B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWìDW# AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëDïHr—¿DWÌDêØHsÀ\ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW·DWÌ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDïHr—¿DVÿDâàHr²`DW·DìHs¤®„DWÌDêØHsÀ\ØPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1013 10131844101318441013DW·DW·BÍREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWìDW# AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëDïHr—¿DWÌDêØHsÀ\ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW·DWÌ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDïHr—¿DVÿDâàHr²`DW·DìHs¤®„DWÌDêØHsÀ\ØPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA0C4591001C4591001 1013 10131844101318441013.DWìC OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWìDW#YAÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVëDïHr—¿DWÌDêØHsÀ\ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW·DWÌ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDïHr—¿DVÿDâàHr²`DW·DìHs¤®„DWÌDêØHsÀ\ØPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA@C4591001C4591001 1013 10131845101318451013DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDŒ Hr˜® DWDÈdHr³HdBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDŒ Hr˜® DWDÈdHr³Hd......Phase 3A@..DWDW´12-15 YearsAYYNY. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1013 10131845101318451013.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW´.DW AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDŒ Hr˜® DWDÈdHr³HdBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDŒ Hr˜® DWDÈdHr³Hd......Phase 3A@..DWDW´12-15 YearsAYYNY. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1013 10131846101318461013DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìD¥ðHr˜ÇðDVÿDßÔHr²TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìD¥ðHr˜ÇðDVÿDßÔHr²T......Phase 3A@DWŽ.DW.12-15 YearsA YNN. DWŽ.DWŽAðYEARSDSAC4591001C4591001 1013 10131846101318461013.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìD¥ðHr˜ÇðDVÿDßÔHr²TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìD¥ðHr˜ÇðDVÿDßÔHr²T......Phase 3A@DWŽ.DW.12-15 YearsA YNN. DWŽ.DWŽAðYEARSDSA C4591001C4591001 1013 10131846101318461013.DWŽB£FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BMother wanted unblinded did not want to continue in study; wanted vaccine in community. DW..DWYAðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìD¥ðHr˜ÇðDVÿDßÔHr²TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìD¥ðHr˜ÇðDVÿDßÔHr²T......Phase 3A@DWŽ.DW.12-15 YearsA YNN. DWŽ.DWŽAðYEARSDSAPC4591001C4591001 1013 10131848101318481013DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD¦hHr˜ÈhDVÿDÛØHr² XPlacebo Placebo 12-15 YearsA . . .DVìDVÿ.....Placebo Placebo Placebo A .Placebo A .DVìD¦hHr˜ÈhDVÿDÛØHr² X......Phase 3A@DWŽ.DW.12-15 YearsAYYNN. DWŽ.DWŽAÀYEARSDSAC4591001C4591001 1013 10131848101318481013.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD¦hHr˜ÈhDVÿDÛØHr² XPlacebo Placebo 12-15 YearsA . . .DVìDVÿ.....Placebo Placebo Placebo A .Placebo A .DVìD¦hHr˜ÈhDVÿDÛØHr² X......Phase 3A@DWŽ.DW.12-15 YearsAYYNN. DWŽ.DWŽAÀYEARSDSA C4591001C4591001 1013 10131848101318481013.DWŽB£FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BMother wanted unblinded did not want to continue in study; wanted vaccine in community. DW..DWYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD¦hHr˜ÈhDVÿDÛØHr² XPlacebo Placebo 12-15 YearsA . . .DVìDVÿ.....Placebo Placebo Placebo A .Placebo A .DVìD¦hHr˜ÈhDVÿDÛØHr² X......Phase 3A@DWŽ.DW.12-15 YearsAYYNN. DWŽ.DWŽAÀYEARSDSAPC4591001C4591001 1013 10131850101318501013DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìD·üHr˜ÙüDWDØÌHr³XÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW¯BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìD·üHr˜ÙüDWDØÌHr³XÌ......Phase 3A@..DW!DW´12-15 YearsAYYNY. DW®DWýDWýAðYEARSDSAC4591001C4591001 1013 10131850101318501013.DW!B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW´.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìD·üHr˜ÙüDWDØÌHr³XÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW¯BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìD·üHr˜ÙüDWDØÌHr³XÌ......Phase 3A@..DW!DW´12-15 YearsAYYNY. DW®DWýDWýAðYEARSDSA C4591001C4591001 1013 10131851101318511013DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWûDW! AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVðDž4Hrž4DW×DÊHsÎ¼ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW´DW×.DW´Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDž4Hrž4DWDÈdHr¹ßäDW´DÉÌHs —ÌDW×DÊHsÎ¼ˆPhase 3A@..DW!.12-15 YearsA YNN. DW³DWýDWýAðYEARSDSA C4591001C4591001 1013 10131851101318511013.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWûDW! AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVðDž4Hrž4DW×DÊHsÎ¼ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW´DW×.DW´Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDž4Hrž4DWDÈdHr¹ßäDW´DÉÌHs —ÌDW×DÊHsÎ¼ˆPhase 3A@..DW!.12-15 YearsA YNN. DW³DWýDWýAðYEARSDSA0C4591001C4591001 1013 10131851101318511013DW´DW´BÅREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWûDW! AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVðDž4Hrž4DW×DÊHsÎ¼ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW´DW×.DW´Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDž4Hrž4DWDÈdHr¹ßäDW´DÉÌHs —ÌDW×DÊHsÎ¼ˆPhase 3A@..DW!.12-15 YearsA YNN. DW³DWýDWýAðYEARSDSA@C4591001C4591001 1013 10131851101318511013.DWûCÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWûDW!YAðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVðDž4Hrž4DW×DÊHsÎ¼ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW´DW×.DW´Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDž4Hrž4DWDÈdHr¹ßäDW´DÉÌHs —ÌDW×DÊHsÎ¼ˆPhase 3A@..DW!.12-15 YearsA YNN. DW³DWýDWýAðYEARSDSAPC4591001C4591001 1013 10131852101318521013DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÒDW! AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¦hHržhDWµDÈÜHs¡è\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW DWµ.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD¦hHržhDWDßÔHr¹÷TDW D× Hs†G DWµDÈÜHs¡è\Phase 3A@..DW!.12-15 YearsA YNN. DW—DWýDWýAàYEARSDSAC4591001C4591001 1013 10131852101318521013.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÒDW! AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¦hHržhDWµDÈÜHs¡è\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW DWµ.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD¦hHržhDWDßÔHr¹÷TDW D× Hs†G DWµDÈÜHs¡è\Phase 3A@..DW!.12-15 YearsA YNN. DW—DWýDWýAàYEARSDSA C4591001C4591001 1013 10131852101318521013DW DW B±REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÒDW! AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¦hHržhDWµDÈÜHs¡è\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW DWµ.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD¦hHržhDWDßÔHr¹÷TDW D× Hs†G DWµDÈÜHs¡è\Phase 3A@..DW!.12-15 YearsA YNN. DW—DWýDWýAàYEARSDSA0C4591001C4591001 1013 10131852101318521013.DWÒBãOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÒDW!YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¦hHržhDWµDÈÜHs¡è\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW DWµ.DW˜Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD¦hHržhDWDßÔHr¹÷TDW D× Hs†G DWµDÈÜHs¡è\Phase 3A@..DW!.12-15 YearsA YNN. DW—DWýDWýAàYEARSDSA@C4591001C4591001 1013 10131855101318551013DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD ŒHrŸZDWDæ(Hr»O(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD ŒHrŸZDWDæ(Hr»O(......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DWµDWýDWýAàYEARSDSAC4591001C4591001 1013 10131855101318551013.DW#B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD ŒHrŸZDWDæ(Hr»O(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD ŒHrŸZDWDæ(Hr»O(......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DWµDWýDWýAàYEARSDSA C4591001C4591001 1013 10131856101318561013DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD´Hr ¿DWDàˆHr¼›BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD´Hr ¿DWDàˆHr¼›......Phase 3A@DW‹.DW/.12-15 YearsA YNN. DW‹.DW‹AðYEARSDSAC4591001C4591001 1013 10131856101318561013.DW/B>VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD´Hr ¿DWDàˆHr¼›BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD´Hr ¿DWDàˆHr¼›......Phase 3A@DW‹.DW/.12-15 YearsA YNN. DW‹.DW‹AðYEARSDSA C4591001C4591001 1013 10131856101318561013.DW‹BšFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject no longer able to make appointments due to drive. DW/..DW/YAðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD´Hr ¿DWDàˆHr¼›BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD´Hr ¿DWDàˆHr¼›......Phase 3A@DW‹.DW/.12-15 YearsA YNN. DW‹.DW‹AðYEARSDSA`C4591001C4591001 1013 10131858101318581013DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"..DW" AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD²˜Hr ½˜DW®D× Hs˜¼ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD²˜Hr ½˜DWDËpHr»4pDW’DÞ¨HssÙ¨DW®D× Hs˜¼ Phase 3A@..DW".12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1013 10131858101318581013.DW"B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"..DW" AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD²˜Hr ½˜DW®D× Hs˜¼ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD²˜Hr ½˜DWDËpHr»4pDW’DÞ¨HssÙ¨DW®D× Hs˜¼ Phase 3A@..DW".12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1013 10131858101318581013DW’DW’B¡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW"..DW" AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD²˜Hr ½˜DW®D× Hs˜¼ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD²˜Hr ½˜DWDËpHr»4pDW’DÞ¨HssÙ¨DW®D× Hs˜¼ Phase 3A@..DW".12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1013 10131859101318591013DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW½.DW) AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD±0Hr ¼0DWD…˜Hr½‘˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW½BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD±0Hr ¼0DWD…˜Hr½‘˜......Phase 3A@..DW)DW½12-15 YearsA YNY. DW¼DWýDWýAðYEARSDSAC4591001C4591001 1013 10131859101318591013.DW)B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW½.DW) AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD±0Hr ¼0DWD…˜Hr½‘˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW½BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD±0Hr ¼0DWD…˜Hr½‘˜......Phase 3A@..DW)DW½12-15 YearsA YNY. DW¼DWýDWýAðYEARSDSA C4591001C4591001 1013 10131860101318601013DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÌDW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÒxHr ÝxDW®DØÌHs˜½ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÒxHr ÝxDWDÑÄHr»:ÄDWšDÕHHs~\HDW®DØÌHs˜½ÌPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1013 10131860101318601013.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÌDW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÒxHr ÝxDW®DØÌHs˜½ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÒxHr ÝxDWDÑÄHr»:ÄDWšDÕHHs~\HDW®DØÌHs˜½ÌPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1013 10131860101318601013DWšDWšB©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÌDW# AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÒxHr ÝxDW®DØÌHs˜½ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÒxHr ÝxDWDÑÄHr»:ÄDWšDÕHHs~\HDW®DØÌHs˜½ÌPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA0C4591001C4591001 1013 10131860101318601013.DWÌBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÌDW#YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÒxHr ÝxDW®DØÌHs˜½ÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÒxHr ÝxDWDÑÄHr»:ÄDWšDÕHHs~\HDW®DØÌHs˜½ÌPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA@C4591001C4591001 1013 10131861101318611013DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DWõ.DW2 AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVóD–xHr¡òøDWDÇ8HrÃ8Placebo Placebo 12-15 YearsA . . .DVóDW....DWõPlacebo Placebo Placebo A .Placebo A .DVóD–xHr¡òøDWDÇ8HrÃ8......Phase 3A@..DW2DWõ12-15 YearsA YNN. DWôDWýDWýAÀYEARSDSAC4591001C4591001 1013 10131861101318611013.DW2B@VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DWõ.DW2 AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVóD–xHr¡òøDWDÇ8HrÃ8Placebo Placebo 12-15 YearsA . . .DVóDW....DWõPlacebo Placebo Placebo A .Placebo A .DVóD–xHr¡òøDWDÇ8HrÃ8......Phase 3A@..DW2DWõ12-15 YearsA YNN. DWôDWýDWýAÀYEARSDSA C4591001C4591001 1013 10131862101318621013DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#..DW# AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD¯Hr¢”DWDÐ˜Hr»9˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWšBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD¯Hr¢”DWDÐ˜Hr»9˜......Phase 3A@DWí.DW#.12-15 YearsA YNY. DW™DWíDWíAÐYEARSDSAC4591001C4591001 1013 10131862101318621013.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#..DW# AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD¯Hr¢”DWDÐ˜Hr»9˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWšBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD¯Hr¢”DWDÐ˜Hr»9˜......Phase 3A@DWí.DW#.12-15 YearsA YNY. DW™DWíDWíAÐYEARSDSA C4591001C4591001 1013 10131862101318621013.DWíBûFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSUBJECT MOVED TO SEATTLE DW#..DW#YAÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD¯Hr¢”DWDÐ˜Hr»9˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWšBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD¯Hr¢”DWDÐ˜Hr»9˜......Phase 3A@DWí.DW#.12-15 YearsA YNY. DW™DWíDWíAÐYEARSDSA`C4591001C4591001 1013 10131863101318631013DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÊDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDèHr¢DˆDWDÈdHs—[äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW˜DW.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDèHr¢DˆDWDÕ„Hr¼DW˜DßÔHs{ÃÔDWDÈdHs—[äPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1013 10131863101318631013.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÊDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDèHr¢DˆDWDÈdHs—[äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW˜DW.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDèHr¢DˆDWDÕ„Hr¼DW˜DßÔHs{ÃÔDWDÈdHs—[äPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1013 10131863101318631013DW˜DW˜B¦REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÊDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDèHr¢DˆDWDÈdHs—[äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW˜DW.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDèHr¢DˆDWDÕ„Hr¼DW˜DßÔHs{ÃÔDWDÈdHs—[äPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1013 10131863101318631013.DWÊBØOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÊDW#YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDèHr¢DˆDWDÈdHs—[äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW˜DW.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDèHr¢DˆDWDÕ„Hr¼DW˜DßÔHs{ÃÔDWDÈdHs—[äPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1013 10131865101318651013DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÅ.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D›dHr§=äDWDàHrÅÕBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D›dHr§=äDWDàHrÅÕ......Phase 3A@..DW*DWÅ12-15 YearsA YNY. DW“DWýDWýAÐYEARSDSAC4591001C4591001 1013 10131865101318651013.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÅ.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D›dHr§=äDWDàHrÅÕBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D›dHr§=äDWDàHrÅÕ......Phase 3A@..DW*DWÅ12-15 YearsA YNY. DW“DWýDWýAÐYEARSDSA C4591001C4591001 1013 10131866101318661013DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÅ.DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dš°Hr§=0DWDß˜HrÅÔ˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dš°Hr§=0DWDß˜HrÅÔ˜......Phase 3A@..DW*DWÅ12-15 YearsA YNY. DW“DWýDWýAðYEARSDSAC4591001C4591001 1013 10131866101318661013.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÅ.DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dš°Hr§=0DWDß˜HrÅÔ˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dš°Hr§=0DWDß˜HrÅÔ˜......Phase 3A@..DW*DWÅ12-15 YearsA YNY. DW“DWýDWýAðYEARSDSA C4591001C4591001 1013 10131867101318671013DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÞDW* AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúD°@Hr«G@DW½Dè€Hs¬”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW DW½.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD°@Hr«G@DW Dß HrÄ‚ DW DËèHs†;èDW½Dè€Hs¬”Phase 3A@..DW*.12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1013 10131867101318671013.DW*B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÞDW* AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúD°@Hr«G@DW½Dè€Hs¬”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW DW½.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD°@Hr«G@DW Dß HrÄ‚ DW DËèHs†;èDW½Dè€Hs¬”Phase 3A@..DW*.12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1013 10131867101318671013DW DW B§REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÞDW* AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúD°@Hr«G@DW½Dè€Hs¬”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW DW½.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD°@Hr«G@DW Dß HrÄ‚ DW DËèHs†;èDW½Dè€Hs¬”Phase 3A@..DW*.12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1013 10131867101318671013.DWÞBåOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÞDW*YAÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúD°@Hr«G@DW½Dè€Hs¬”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW DW½.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD°@Hr«G@DW Dß HrÄ‚ DW DËèHs†;èDW½Dè€Hs¬”Phase 3A@..DW*.12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1013 10131868101318681013DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2..DW2 AÐYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVþD› Hr°x DWDÑÄHrÍ¯ÄPlacebo Placebo 12-15 YearsA . . .DVþDW.....Placebo Placebo Placebo A .Placebo A .DVþD› Hr°x DWDÑÄHrÍ¯Ä......Phase 3A@DW’.DW2.12-15 YearsA YNN. DW’.DW’AÐYEARSDSAC4591001C4591001 1013 10131868101318681013.DW2B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2..DW2 AÐYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVþD› Hr°x DWDÑÄHrÍ¯ÄPlacebo Placebo 12-15 YearsA . . .DVþDW.....Placebo Placebo Placebo A .Placebo A .DVþD› Hr°x DWDÑÄHrÍ¯Ä......Phase 3A@DW’.DW2.12-15 YearsA YNN. DW’.DW’AÐYEARSDSA C4591001C4591001 1013 10131868101318681013.DW’B•FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject received first dose in community. DW2..DW2YAÐYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVþD› Hr°x DWDÑÄHrÍ¯ÄPlacebo Placebo 12-15 YearsA . . .DVþDW.....Placebo Placebo Placebo A .Placebo A .DVþD› Hr°x DWDÑÄHrÍ¯Ä......Phase 3A@DW’.DW2.12-15 YearsA YNN. DW’.DW’AÐYEARSDSA`C4591001C4591001 1013 10131869101318691013DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD©ìHr°†ìDWDàÄHrÏDPlacebo Placebo 12-15 YearsA . . .DVþDW....DW¡Placebo Placebo Placebo A .Placebo A .DVþD©ìHr°†ìDWDàÄHrÏD......Phase 3A@DW¡.DW6.12-15 YearsA YNN. DW DW¡DW¡AàYEARSDSAC4591001C4591001 1013 10131869101318691013.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD©ìHr°†ìDWDàÄHrÏDPlacebo Placebo 12-15 YearsA . . .DVþDW....DW¡Placebo Placebo Placebo A .Placebo A .DVþD©ìHr°†ìDWDàÄHrÏD......Phase 3A@DW¡.DW6.12-15 YearsA YNN. DW DW¡DW¡AàYEARSDSA C4591001C4591001 1013 10131869101318691013.DW¡B¤FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject wanted to get vaccine closer to home. DW6..DW6YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD©ìHr°†ìDWDàÄHrÏDPlacebo Placebo 12-15 YearsA . . .DVþDW....DW¡Placebo Placebo Placebo A .Placebo A .DVþD©ìHr°†ìDWDàÄHrÏD......Phase 3A@DW¡.DW6.12-15 YearsA YNN. DW DW¡DW¡AàYEARSDSApC4591001C4591001 1013 10131870101318701013DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDª Hr°‡ DWDàˆHrÏPlacebo Placebo 12-15 YearsA . . .DVþDW.....Placebo Placebo Placebo A .Placebo A .DVþDª Hr°‡ DWDàˆHrÏ......Phase 3A@DWx.DW6.12-15 YearsA YNN. DWx.DWxAðYEARSDSAC4591001C4591001 1013 10131870101318701013.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDª Hr°‡ DWDàˆHrÏPlacebo Placebo 12-15 YearsA . . .DVþDW.....Placebo Placebo Placebo A .Placebo A .DVþDª Hr°‡ DWDàˆHrÏ......Phase 3A@DWx.DW6.12-15 YearsA YNN. DWx.DWxAðYEARSDSA C4591001C4591001 1013 10131870101318701013.DWxB{FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject could not make the time commitment with 2 hour drive. DW6..DW6YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDª Hr°‡ DWDàˆHrÏPlacebo Placebo 12-15 YearsA . . .DVþDW.....Placebo Placebo Placebo A .Placebo A .DVþDª Hr°‡ DWDàˆHrÏ......Phase 3A@DWx.DW6.12-15 YearsA YNN. DWx.DWxAðYEARSDSA`C4591001C4591001 1013 10131871101318711013DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÃ.DW/ AÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD½`Hr°š`DWDáHrÌm€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD½`Hr°š`DWDáHrÌm€......Phase 3A@..DW/DWÃ12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1013 10131871101318711013.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÃ.DW/ AÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD½`Hr°š`DWDáHrÌm€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD½`Hr°š`DWDáHrÌm€......Phase 3A@..DW/DWÃ12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1013 10131872101318721013DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÃ.DW/ AÀYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¼¬Hr°™¬DWDßÔHrÌlTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¼¬Hr°™¬DWDßÔHrÌlT......Phase 3A@..DW/DWÃ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1013 10131872101318721013.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÃ.DW/ AÀYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¼¬Hr°™¬DWDßÔHrÌlTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¼¬Hr°™¬DWDßÔHrÌlT......Phase 3A@..DW/DWÃ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1013 10131873101318731013DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÑ.DW* AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD·HHr±åÈDWDÆ„HrÎöBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD·HHr±åÈDWDÆ„HrÎö......Phase 3A@..DW*DWÑ12-15 YearsA YNY. DWý.DWýAÐYEARSDSA C4591001C4591001 1013 10131873101318731013.DW*B,VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÑ.DW* AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD·HHr±åÈDWDÆ„HrÎöBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD·HHr±åÈDWDÆ„HrÎö......Phase 3A@..DW*DWÑ12-15 YearsA YNY. DWý.DWýAÐYEARSDSA0C4591001C4591001 1013 10131874101318741013DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*..DW* AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVÿD¬Hr±ÚˆDWçDÃ´HsãÎ4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWÑDWç.DWÑPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD¬Hr±ÚˆDWDÄàHrÎô`DWÑDÜPHsÆåÐDWçDÃ´HsãÎ4Phase 3A@..DW*.12-15 YearsA YNN. DWÐDWýDWýAÀYEARSDSA C4591001C4591001 1013 10131874101318741013.DW*B,VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*..DW* AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVÿD¬Hr±ÚˆDWçDÃ´HsãÎ4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWÑDWç.DWÑPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD¬Hr±ÚˆDWDÄàHrÎô`DWÑDÜPHsÆåÐDWçDÃ´HsãÎ4Phase 3A@..DW*.12-15 YearsA YNN. DWÐDWýDWýAÀYEARSDSA0C4591001C4591001 1013 10131874101318741013DWÑDWÑBÓREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*..DW* AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVÿD¬Hr±ÚˆDWçDÃ´HsãÎ4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWÑDWç.DWÑPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD¬Hr±ÚˆDWDÄàHrÎô`DWÑDÜPHsÆåÐDWçDÃ´HsãÎ4Phase 3A@..DW*.12-15 YearsA YNN. DWÐDWýDWýAÀYEARSDSA@C4591001C4591001 1013 10131875101318751013DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÐDW1 AàYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿD¬¼Hr±Û<DWDÉHs—\˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW˜DW.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD¬¼Hr±Û<DWDß HrÏ DW˜DÑÄHs{µÄDWDÉHs—\˜Phase 3A@..DW1.12-15 YearsA YNN. DW“DWýDWýAàYEARSDSAC4591001C4591001 1013 10131875101318751013.DW1B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÐDW1 AàYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿD¬¼Hr±Û<DWDÉHs—\˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW˜DW.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD¬¼Hr±Û<DWDß HrÏ DW˜DÑÄHs{µÄDWDÉHs—\˜Phase 3A@..DW1.12-15 YearsA YNN. DW“DWýDWýAàYEARSDSA C4591001C4591001 1013 10131875101318751013DW˜DW˜BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÐDW1 AàYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿD¬¼Hr±Û<DWDÉHs—\˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW˜DW.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD¬¼Hr±Û<DWDß HrÏ DW˜DÑÄHs{µÄDWDÉHs—\˜Phase 3A@..DW1.12-15 YearsA YNN. DW“DWýDWýAàYEARSDSA0C4591001C4591001 1013 10131875101318751013.DWÐBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÐDW1YAàYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿD¬¼Hr±Û<DWDÉHs—\˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW˜DW.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD¬¼Hr±Û<DWDß HrÏ DW˜DÑÄHs{µÄDWDÉHs—\˜Phase 3A@..DW1.12-15 YearsA YNN. DW“DWýDWýAàYEARSDSA@C4591001C4591001 1013 10131876101318761013DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÉ.DW7 AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD¸8Hr±æ¸DWDÆÀHrÍ¤ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD¸8Hr±æ¸DWDÆÀHrÍ¤À......Phase 3A@..DW7DWÉ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1013 10131876101318761013.DW7B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÉ.DW7 AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD¸8Hr±æ¸DWDÆÀHrÍ¤ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD¸8Hr±æ¸DWDÆÀHrÍ¤À......Phase 3A@..DW7DWÉ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1013 10131877101318771013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÊ.DWD AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŠHHr³ HDWDãHrÏœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŠHHr³ HDWDãHrÏœ......Phase 3A@..DWDDWÊ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1013 10131877101318771013.DWDBEVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÊ.DWD AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŠHHr³ HDWDãHrÏœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŠHHr³ HDWDãHrÏœ......Phase 3A@..DWDDWÊ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1013 10131878101318781013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‘PHr³PDWDÞ¨HrÏ(Placebo Placebo 12-15 YearsA . . .DWDW....DW‘Placebo Placebo Placebo A .Placebo A .DWD‘PHr³PDWDÞ¨HrÏ(......Phase 3A@DW™.DW7.12-15 YearsA YNN. DWDW™DW™AÀYEARSDSAC4591001C4591001 1013 10131878101318781013.DW7B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‘PHr³PDWDÞ¨HrÏ(Placebo Placebo 12-15 YearsA . . .DWDW....DW‘Placebo Placebo Placebo A .Placebo A .DWD‘PHr³PDWDÞ¨HrÏ(......Phase 3A@DW™.DW7.12-15 YearsA YNN. DWDW™DW™AÀYEARSDSA C4591001C4591001 1013 10131878101318781013.DW™BšFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BUnable to make further appointments - vaccinated in community. DW7..DW7YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‘PHr³PDWDÞ¨HrÏ(Placebo Placebo 12-15 YearsA . . .DWDW....DW‘Placebo Placebo Placebo A .Placebo A .DWD‘PHr³PDWDÞ¨HrÏ(......Phase 3A@DW™.DW7.12-15 YearsA YNN. DWDW™DW™AÀYEARSDSApC4591001C4591001 1013 10131879101318791013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DW¯DW/ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèHr³èDW“DÜŒHsu)Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW~DW“.DWxPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèHr³èDWDå8HrÌq¸DW~DÝHsYzDW“DÜŒHsu)Phase 3A@..DW/.12-15 YearsA YNN. DWwDWýDWýAðYEARSDSA C4591001C4591001 1013 10131879101318791013.DW/B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DW¯DW/ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèHr³èDW“DÜŒHsu)Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW~DW“.DWxPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèHr³èDWDå8HrÌq¸DW~DÝHsYzDW“DÜŒHsu)Phase 3A@..DW/.12-15 YearsA YNN. DWwDWýDWýAðYEARSDSA0C4591001C4591001 1013 10131879101318791013DW~DW~BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DW¯DW/ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèHr³èDW“DÜŒHsu)Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW~DW“.DWxPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèHr³èDWDå8HrÌq¸DW~DÝHsYzDW“DÜŒHsu)Phase 3A@..DW/.12-15 YearsA YNN. DWwDWýDWýAðYEARSDSA@C4591001C4591001 1013 10131879101318791013.DW¯B°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DW¯DW/YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèHr³èDW“DÜŒHsu)Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW~DW“.DWxPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèHr³èDWDå8HrÌq¸DW~DÝHsYzDW“DÜŒHsu)Phase 3A@..DW/.12-15 YearsA YNN. DWwDWýDWýAðYEARSDSAPC4591001C4591001 1013 10131880101318801013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÃ.DW/ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŽDHr³DDWDå°HrÌr0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŽDHr³DDWDå°HrÌr0......Phase 3A@..DW/DWÃ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1013 10131880101318801013.DW/B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÃ.DW/ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŽDHr³DDWDå°HrÌr0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŽDHr³DDWDå°HrÌr0......Phase 3A@..DW/DWÃ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1013 10131881101318811013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÌ.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¥<Hr¹¼¼DWDÔXHrØ>XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWÌBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¥<Hr¹¼¼DWDÔXHrØ>X......Phase 3A@..DW8DWÌ12-15 YearsA YNY. DWËDWýDWýAàYEARSDSAC4591001C4591001 1013 10131881101318811013.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÌ.DW8 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¥<Hr¹¼¼DWDÔXHrØ>XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWÌBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¥<Hr¹¼¼DWDÔXHrØ>X......Phase 3A@..DW8DWÌ12-15 YearsA YNY. DWËDWýDWýAàYEARSDSA C4591001C4591001 1013 10131882101318821013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÆDW9 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD™„Hr¼TDW¦DåtHsŽ>tPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™„Hr¼TDWDÔXHrÖìØDW‘DÒðHsr|pDW¦DåtHsŽ>tPhase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1013 10131882101318821013.DW9B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÆDW9 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD™„Hr¼TDW¦DåtHsŽ>tPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™„Hr¼TDWDÔXHrÖìØDW‘DÒðHsr|pDW¦DåtHsŽ>tPhase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1013 10131882101318821013DW‘DW‘B‹REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÆDW9 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD™„Hr¼TDW¦DåtHsŽ>tPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™„Hr¼TDWDÔXHrÖìØDW‘DÒðHsr|pDW¦DåtHsŽ>tPhase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1013 10131882101318821013.DWÆBÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÆDW9YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD™„Hr¼TDW¦DåtHsŽ>tPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™„Hr¼TDWDÔXHrÖìØDW‘DÒðHsr|pDW¦DåtHsŽ>tPhase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1013 10131883101318831013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÅDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDš°Hr½¦°DW©Dâ¤Hs’0$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW©.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDš°Hr½¦°DWDèøHrÙ¤xDW”DêØHsvˆØDW©Dâ¤Hs’0$Phase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1013 10131883101318831013.DW?B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÅDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDš°Hr½¦°DW©Dâ¤Hs’0$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW©.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDš°Hr½¦°DWDèøHrÙ¤xDW”DêØHsvˆØDW©Dâ¤Hs’0$Phase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1013 10131883101318831013DW”DW”BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÅDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDš°Hr½¦°DW©Dâ¤Hs’0$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW©.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDš°Hr½¦°DWDèøHrÙ¤xDW”DêØHsvˆØDW©Dâ¤Hs’0$Phase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1013 10131883101318831013.DWÅB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÅDW?YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDš°Hr½¦°DW©Dâ¤Hs’0$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW©.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDš°Hr½¦°DWDèøHrÙ¤xDW”DêØHsvˆØDW©Dâ¤Hs’0$Phase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1013 10131884101318841013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWî.DW@ AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌHrÆÔLDW$Dé¬Hrâß¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌHrÆÔLDW$Dé¬Hrâß¬......Phase 3A@..DW@DWî12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1013 10131884101318841013.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWî.DW@ AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌHrÆÔLDW$Dé¬Hrâß¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌHrÆÔLDW$Dé¬Hrâß¬......Phase 3A@..DW@DWî12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1013 10131885101318851013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽøHrÆÕxDW®DÉHs˜®Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW›DW®.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŽøHrÆÕxDW"DàˆHrà3ˆDW›DÉHs¢DW®DÉHs˜®Phase 3A@..DW?.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1013 10131885101318851013.DW?B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽøHrÆÕxDW®DÉHs˜®Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW›DW®.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŽøHrÆÕxDW"DàˆHrà3ˆDW›DÉHs¢DW®DÉHs˜®Phase 3A@..DW?.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1013 10131885101318851013DW›DW›BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽøHrÆÕxDW®DÉHs˜®Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW›DW®.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŽøHrÆÕxDW"DàˆHrà3ˆDW›DÉHs¢DW®DÉHs˜®Phase 3A@..DW?.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1013 10131885101318851013.DWÊB¼OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÊDW?YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽøHrÆÕxDW®DÉHs˜®Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW›DW®.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŽøHrÆÕxDW"DàˆHrà3ˆDW›DÉHs¢DW®DÉHs˜®Phase 3A@..DW?.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1013 10131886101318861013DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÆDW? AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW©Dá´Hs’/4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW©.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW#DØÌHrá}LDW“DˆhHstÔèDW©Dá´Hs’/4Phase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1013 10131886101318861013.DW?B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÆDW? AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW©Dá´Hs’/4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW©.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW#DØÌHrá}LDW“DˆhHstÔèDW©Dá´Hs’/4Phase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1013 10131886101318861013DW“DW“B…REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÆDW? AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW©Dá´Hs’/4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW©.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW#DØÌHrá}LDW“DˆhHstÔèDW©Dá´Hs’/4Phase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1013 10131886101318861013.DWÆB¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÆDW?YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW©Dá´Hs’/4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW©.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW#DØÌHrá}LDW“DˆhHstÔèDW©Dá´Hs’/4Phase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161307101613071016DV»DV»ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVìDW€DWÆDVì AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV»D¬øHrX5xDW©Dš°Hs‘è0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÏ.DW“DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D¬øHrX5xDVÏD’|HrrxüDW“D™„HstæDW©Dš°Hs‘è0Phase 3A@..DVìDW€12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161307101613071016.DVìB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVìDW€DWÆDVì AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV»D¬øHrX5xDW©Dš°Hs‘è0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÏ.DW“DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D¬øHrX5xDVÏD’|HrrxüDW“D™„HstæDW©Dš°Hs‘è0Phase 3A@..DVìDW€12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161307101613071016DW“DW“BÙREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVìDW€DWÆDVì AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV»D¬øHrX5xDW©Dš°Hs‘è0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÏ.DW“DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D¬øHrX5xDVÏD’|HrrxüDW“D™„HstæDW©Dš°Hs‘è0Phase 3A@..DVìDW€12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1016 10161307101613071016.DWÆCÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVìDW€DWÆDVìYAÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV»D¬øHrX5xDW©Dš°Hs‘è0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÏ.DW“DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D¬øHrX5xDVÏD’|HrrxüDW“D™„HstæDW©Dš°Hs‘è0Phase 3A@..DVìDW€12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1016 10161308101613081016DV»DV»ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVðDWƒDWÉDVð AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»D®`HrX6àDWD‚PHs—ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÎ.DWšDW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D®`HrX6àDVÎD†LHrqLDWšDŠÀHs~ÀDWD‚PHs—ÐPhase 3A@..DVðDWƒ12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161308101613081016.DVðB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWƒDWÉDVð AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»D®`HrX6àDWD‚PHs—ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÎ.DWšDW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D®`HrX6àDVÎD†LHrqLDWšDŠÀHs~ÀDWD‚PHs—ÐPhase 3A@..DVðDWƒ12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161308101613081016DWšDWšBàREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWƒDWÉDVð AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»D®`HrX6àDWD‚PHs—ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÎ.DWšDW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D®`HrX6àDVÎD†LHrqLDWšDŠÀHs~ÀDWD‚PHs—ÐPhase 3A@..DVðDWƒ12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1016 10161308101613081016.DWÉCðOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWƒDWÉDVðYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV»D®`HrX6àDWD‚PHs—ÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV»DVÎ.DWšDW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV»D®`HrX6àDVÎD†LHrqLDWšDŠÀHs~ÀDWD‚PHs—ÐPhase 3A@..DVðDWƒ12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1016 10161309101613091016DV»DV»ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVùDW.DVù AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»DÑˆHrXZDV×D£ÔHr}TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DV×....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»DÑˆHrXZDV×D£ÔHr}T......Phase 3A@..DVùDW12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1016 10161309101613091016.DVùB?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVùDW.DVù AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»DÑˆHrXZDV×D£ÔHr}TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DV×....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»DÑˆHrXZDV×D£ÔHr}T......Phase 3A@..DVùDW12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1016 10161310101613101016DV»DV»ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVëDW.DVë AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»DÔ”HrX]DVÏD„0Hrrj°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DVÏ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»DÔ”HrX]DVÏD„0Hrrj°......Phase 3A@..DVëDW12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161310101613101016.DVëB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVëDW.DVë AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»DÔ”HrX]DVÏD„0Hrrj°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DVÏ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»DÔ”HrX]DVÏD„0Hrrj°......Phase 3A@..DVëDW12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161311101613111016DV»DV»ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVëDW.DVë AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»DÚpHrXbðDVÎDÊHrq_BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DVÎ....DW@BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»DÚpHrXbðDVÎDÊHrq_......Phase 3A@..DVëDW12-15 YearsA YNY. DW?DWýDWýAðYEARSDSAC4591001C4591001 1016 10161311101613111016.DVëB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVëDW.DVë AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV»DÚpHrXbðDVÎDÊHrq_BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV»DVÎ....DW@BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV»DÚpHrXbðDVÎDÊHrq_......Phase 3A@..DVëDW12-15 YearsA YNY. DW?DWýDWýAðYEARSDSA C4591001C4591001 1016 10161314101613141016DV¼DV¼ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVíDW€.DVí AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¼D¼HrYw¼DVÐDŒ(HrsÄ(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¼DVÐ.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¼D¼HrYw¼DVÐDŒ(HrsÄ(......Phase 3A@..DVíDW€12-15 YearsA YNY. DWý.DWýAÐYEARSDSAC4591001C4591001 1016 10161314101613141016.DVíB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVíDW€.DVí AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¼D¼HrYw¼DVÐDŒ(HrsÄ(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¼DVÐ.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¼D¼HrYw¼DVÐDŒ(HrsÄ(......Phase 3A@..DVíDW€12-15 YearsA YNY. DWý.DWýAÐYEARSDSA C4591001C4591001 1016 10161315101613151016DV¼DV¼ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVíDWƒDWÄDVí AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÓ,HrY,DW¨DÞ¨HsÚ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÑ.DW”DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÓ,HrY,DVÑD”ÔHruTDW”DÎ@Hsvl@DW¨DÞ¨HsÚ¨Phase 3A@..DVíDWƒ12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1016 10161315101613151016.DVíB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVíDWƒDWÄDVí AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÓ,HrY,DW¨DÞ¨HsÚ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÑ.DW”DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÓ,HrY,DVÑD”ÔHruTDW”DÎ@Hsvl@DW¨DÞ¨HsÚ¨Phase 3A@..DVíDWƒ12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1016 10161315101613151016DW”DW”BÙREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVíDWƒDWÄDVí AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÓ,HrY,DW¨DÞ¨HsÚ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÑ.DW”DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÓ,HrY,DVÑD”ÔHruTDW”DÎ@Hsvl@DW¨DÞ¨HsÚ¨Phase 3A@..DVíDWƒ12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1016 10161315101613151016.DWÄCOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVíDWƒDWÄDVíYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÓ,HrY,DW¨DÞ¨HsÚ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÑ.DW”DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÓ,HrY,DVÑD”ÔHruTDW”DÎ@Hsvl@DW¨DÞ¨HsÚ¨Phase 3A@..DVíDWƒ12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1016 10161316101613161016DV¼DV¼ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DV÷.DWoDV÷ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÕHHrY¯HDWSDÌœHs ¹Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼..DW@DWS.DW>Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÕHHrY¯HDV¼DÕHHrY¯HDW@DÏlHs¯lDWSDÌœHs ¹Phase 3A@.DVÌDV÷.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSAC4591001C4591001 1016 10161316101613161016DW@DW@B…REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DV÷.DWoDV÷ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÕHHrY¯HDWSDÌœHs ¹Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼..DW@DWS.DW>Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÕHHrY¯HDV¼DÕHHrY¯HDW@DÏlHs¯lDWSDÌœHs ¹Phase 3A@.DVÌDV÷.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA C4591001C4591001 1016 10161316101613161016.DWoB´OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DV÷.DWoDV÷YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÕHHrY¯HDWSDÌœHs ¹Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼..DW@DWS.DW>Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÕHHrY¯HDV¼DÕHHrY¯HDW@DÏlHs¯lDWSDÌœHs ¹Phase 3A@.DVÌDV÷.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA0C4591001C4591001 1016 10161316101613161016.DVÌBVACCINATION BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABsubject with positive covid-19 DV÷.DWoDV÷ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÕHHrY¯HDWSDÌœHs ¹Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼..DW@DWS.DW>Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÕHHrY¯HDV¼DÕHHrY¯HDW@DÏlHs¯lDWSDÌœHs ¹Phase 3A@.DVÌDV÷.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA`C4591001C4591001 1016 10161318101613181016DV¼DV¼ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVíDWƒDWØDVí AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÜHrY¶DW¼DÐÔHs«*ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW©DW¼.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÜHrY¶DVÏDÐ Hrr¶ DW©DÖ8Hs’#¸DW¼DÐÔHs«*ÔPhase 3A@..DVíDWƒ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1016 10161318101613181016.DVíB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVíDWƒDWØDVí AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÜHrY¶DW¼DÐÔHs«*ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW©DW¼.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÜHrY¶DVÏDÐ Hrr¶ DW©DÖ8Hs’#¸DW¼DÐÔHs«*ÔPhase 3A@..DVíDWƒ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1016 10161318101613181016DW©DW©BîREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVíDWƒDWØDVí AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÜHrY¶DW¼DÐÔHs«*ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW©DW¼.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÜHrY¶DVÏDÐ Hrr¶ DW©DÖ8Hs’#¸DW¼DÐÔHs«*ÔPhase 3A@..DVíDWƒ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1016 10161318101613181016.DWØCÐOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVíDWƒDWØDVíYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼DÜHrY¶DW¼DÐÔHs«*ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW©DW¼.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼DÜHrY¶DVÏDÐ Hrr¶ DW©DÖ8Hs’#¸DW¼DÐÔHs«*ÔPhase 3A@..DVíDWƒ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1016 10161319101613191016DV¼DV¼ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVëDWDWÉDVë AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼Dß\HrY¹\DWDÕüHs—i|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW™DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼Dß\HrY¹\DVÏDÎ|Hrr´üDW™Dâ¤Hs}$DWDÕüHs—i|Phase 3A@..DVëDW12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1016 10161319101613191016.DVëB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVëDWDWÉDVë AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼Dß\HrY¹\DWDÕüHs—i|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW™DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼Dß\HrY¹\DVÏDÎ|Hrr´üDW™Dâ¤Hs}$DWDÕüHs—i|Phase 3A@..DVëDW12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1016 10161319101613191016DW™DW™BÞREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVëDWDWÉDVë AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼Dß\HrY¹\DWDÕüHs—i|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW™DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼Dß\HrY¹\DVÏDÎ|Hrr´üDW™Dâ¤Hs}$DWDÕüHs—i|Phase 3A@..DVëDW12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161319101613191016.DWÉCàOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVëDWDWÉDVëYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV¼Dß\HrY¹\DWDÕüHs—i|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¼DVÏ.DW™DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¼Dß\HrY¹\DVÏDÎ|Hrr´üDW™Dâ¤Hs}$DWDÕüHs—i|Phase 3A@..DVëDW12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161320101613201016DVÁDV¿Á SCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVñDW„.DVñ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDœTHr` ÔDVÔDŽ€Hry€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÔ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDœTHr` ÔDVÔDŽ€Hry€......Phase 3A@..DVñDW„12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1016 10161320101613201016.DVñB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVñDW„.DVñ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDœTHr` ÔDVÔDŽ€Hry€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÔ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDœTHr` ÔDVÔDŽ€Hry€......Phase 3A@..DVñDW„12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1016 10161322101613221016DV¿DV¿ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVðDW„.DVð AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿D¦àHr]u`DVÔD’¸Hry¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÔ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿D¦àHr]u`DVÔD’¸Hry¸......Phase 3A@..DVðDW„12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1016 10161322101613221016.DVðB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVðDW„.DVð AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿D¦àHr]u`DVÔD’¸Hry¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÔ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿D¦àHr]u`DVÔD’¸Hry¸......Phase 3A@..DVðDW„12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1016 10161323101613231016DV¿DV¿ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVðDWŒ.DVð AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿DÅÐHr]”PDVÔD¤ˆHry"ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÔ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿DÅÐHr]”PDVÔD¤ˆHry"ˆ......Phase 3A@..DVðDWŒ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161323101613231016.DVðB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWŒ.DVð AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿DÅÐHr]”PDVÔD¤ˆHry"ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÔ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿DÅÐHr]”PDVÔD¤ˆHry"ˆ......Phase 3A@..DVðDWŒ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161324101613241016DV¿DV¿ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVðDWŒDWÌDVð AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV¿DÅXHr]“ØDW°DÉÌHs›QÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¿DVÔ.DW›DW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¿DÅXHr]“ØDVÔD¥Hry#DW›DÒðHs«pDW°DÉÌHs›QÌPhase 3A@..DVðDWŒ12-15 YearsAYYNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1016 10161324101613241016.DVðB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWŒDWÌDVð AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV¿DÅXHr]“ØDW°DÉÌHs›QÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¿DVÔ.DW›DW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¿DÅXHr]“ØDVÔD¥Hry#DW›DÒðHs«pDW°DÉÌHs›QÌPhase 3A@..DVðDWŒ12-15 YearsAYYNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1016 10161324101613241016DW›DW›BÝREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWŒDWÌDVð AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV¿DÅXHr]“ØDW°DÉÌHs›QÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¿DVÔ.DW›DW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¿DÅXHr]“ØDVÔD¥Hry#DW›DÒðHs«pDW°DÉÌHs›QÌPhase 3A@..DVðDWŒ12-15 YearsAYYNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1016 10161324101613241016.DWÌCàOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWŒDWÌDVðYAðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV¿DÅXHr]“ØDW°DÉÌHs›QÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV¿DVÔ.DW›DW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV¿DÅXHr]“ØDVÔD¥Hry#DW›DÒðHs«pDW°DÉÌHs›QÌPhase 3A@..DVðDWŒ12-15 YearsAYYNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1016 10161325101613251016DV¿DV¿ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVñDW….DVñ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿DÒxHr] øDVÕDß˜Hrz¯BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÕ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿DÒxHr] øDVÕDß˜Hrz¯......Phase 3A@..DVñDW…12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1016 10161325101613251016.DVñB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVñDW….DVñ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV¿DÒxHr] øDVÕDß˜Hrz¯BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV¿DVÕ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV¿DÒxHr] øDVÕDß˜Hrz¯......Phase 3A@..DVñDW…12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1016 10161326101613261016DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVñDW‡.DVñ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀD‰XHr^©XDVÕD—àHrzg`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÕ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀD‰XHr^©XDVÕD—àHrzg`......Phase 3A@..DVñDW‡12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1016 10161326101613261016.DVñB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVñDW‡.DVñ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀD‰XHr^©XDVÕD—àHrzg`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÕ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀD‰XHr^©XDVÕD—àHrzg`......Phase 3A@..DVñDW‡12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1016 10161327101613271016DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVñDW‡DWÑDVñ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀD‰XHr^©XDWµDƒ¸Hs¡£8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÕ.DW DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀD‰XHr^©XDVÕD—¤Hrzg$DW DÖtHs†FtDWµDƒ¸Hs¡£8Phase 3A@..DVñDW‡12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161327101613271016.DVñB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVñDW‡DWÑDVñ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀD‰XHr^©XDWµDƒ¸Hs¡£8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÕ.DW DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀD‰XHr^©XDVÕD—¤Hrzg$DW DÖtHs†FtDWµDƒ¸Hs¡£8Phase 3A@..DVñDW‡12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161327101613271016DW DW BáREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVñDW‡DWÑDVñ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀD‰XHr^©XDWµDƒ¸Hs¡£8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÕ.DW DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀD‰XHr^©XDVÕD—¤Hrzg$DW DÖtHs†FtDWµDƒ¸Hs¡£8Phase 3A@..DVñDW‡12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161327101613271016.DWÑC OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVñDW‡DWÑDVñYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀD‰XHr^©XDWµDƒ¸Hs¡£8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÕ.DW DWµ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀD‰XHr^©XDVÕD—¤Hrzg$DW DÖtHs†FtDWµDƒ¸Hs¡£8Phase 3A@..DVñDW‡12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161329101613291016DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW‡DWÄDV÷ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDŠüHr^ªüDW¨Dß\HsÛ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÕ.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDŠüHr^ªüDVÕDæ Hrz¶ DW“DÔ”Hsu!DW¨Dß\HsÛ\Phase 3A@..DV÷DW‡12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1016 10161329101613291016.DV÷B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW‡DWÄDV÷ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDŠüHr^ªüDW¨Dß\HsÛ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÕ.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDŠüHr^ªüDVÕDæ Hrz¶ DW“DÔ”Hsu!DW¨Dß\HsÛ\Phase 3A@..DV÷DW‡12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1016 10161329101613291016DW“DW“BÔREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW‡DWÄDV÷ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDŠüHr^ªüDW¨Dß\HsÛ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÕ.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDŠüHr^ªüDVÕDæ Hrz¶ DW“DÔ”Hsu!DW¨Dß\HsÛ\Phase 3A@..DV÷DW‡12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1016 10161329101613291016.DWÄCPOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DV÷DW‡DWÄDV÷YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDŠüHr^ªüDW¨Dß\HsÛ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÕ.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDŠüHr^ªüDVÕDæ Hrz¶ DW“DÔ”Hsu!DW¨Dß\HsÛ\Phase 3A@..DV÷DW‡12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1016 10161330101613301016DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVôDW‹.DVô AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀDÒ´Hr^ò´DVÖDâ¤Hr|¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÖ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀDÒ´Hr^ò´DVÖDâ¤Hr|¤......Phase 3A@..DVôDW‹12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161330101613301016.DVôB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVôDW‹.DVô AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÀDÒ´Hr^ò´DVÖDâ¤Hr|¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÀDVÖ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÀDÒ´Hr^ò´DVÖDâ¤Hr|¤......Phase 3A@..DVôDW‹12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161331101613311016DVÀDVÀASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVòDW†DWÉDVò AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDÑˆHr^ñˆDWD§ÐHs—;PPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÖ.DWšDW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDÑˆHr^ñˆDVÖDð<Hr|<DWšDãXHs~jXDWD§ÐHs—;PPhase 3A@..DVòDW†12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1016 10161331101613311016.DVòB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVòDW†DWÉDVò AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDÑˆHr^ñˆDWD§ÐHs—;PPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÖ.DWšDW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDÑˆHr^ñˆDVÖDð<Hr|<DWšDãXHs~jXDWD§ÐHs—;PPhase 3A@..DVòDW†12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1016 10161331101613311016DWšDWšBÛREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVòDW†DWÉDVò AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDÑˆHr^ñˆDWD§ÐHs—;PPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÖ.DWšDW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDÑˆHr^ñˆDVÖDð<Hr|<DWšDãXHs~jXDWD§ÐHs—;PPhase 3A@..DVòDW†12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161331101613311016.DWÉC OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVòDW†DWÉDVòYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÀDÑˆHr^ñˆDWD§ÐHs—;PPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÀDVÖ.DWšDW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÀDÑˆHr^ñˆDVÖDð<Hr|<DWšDãXHs~jXDWD§ÐHs—;PPhase 3A@..DVòDW†12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161332101613321016DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVðDWŒ.DVð AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDÍHr`>”DVÔD£ÔHry!ÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÔ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDÍHr`>”DVÔD£ÔHry!Ô......Phase 3A@..DVðDWŒ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1016 10161332101613321016.DVðB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVðDWŒ.DVð AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDÍHr`>”DVÔD£ÔHry!ÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÔ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDÍHr`>”DVÔD£ÔHry!Ô......Phase 3A@..DVðDWŒ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1016 10161334101613341016DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVóDW‡DWËDVó AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDÒ´Hr`D4DW®D‡´Hs˜l´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DW›DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDÒ´Hr`D4DVÖDß\Hr|\DW›DæÜHs¿\DW®D‡´Hs˜l´Phase 3A@..DVóDW‡12-15 YearsAYYNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1016 10161334101613341016.DVóB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW‡DWËDVó AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDÒ´Hr`D4DW®D‡´Hs˜l´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DW›DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDÒ´Hr`D4DVÖDß\Hr|\DW›DæÜHs¿\DW®D‡´Hs˜l´Phase 3A@..DVóDW‡12-15 YearsAYYNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1016 10161334101613341016DW›DW›BÛREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW‡DWËDVó AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDÒ´Hr`D4DW®D‡´Hs˜l´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DW›DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDÒ´Hr`D4DVÖDß\Hr|\DW›DæÜHs¿\DW®D‡´Hs˜l´Phase 3A@..DVóDW‡12-15 YearsAYYNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1016 10161334101613341016.DWËC°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW‡DWËDVóYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDÒ´Hr`D4DW®D‡´Hs˜l´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DW›DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDÒ´Hr`D4DVÖDß\Hr|\DW›DæÜHs¿\DW®D‡´Hs˜l´Phase 3A@..DVóDW‡12-15 YearsAYYNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1016 10161335101613351016DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŒ.DVò AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDìôHr`^tDVÖD“0Hr{´0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÖ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDìôHr`^tDVÖD“0Hr{´0......Phase 3A@..DVòDWŒ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161335101613351016.DVòB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŒ.DVò AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÁDìôHr`^tDVÖD“0Hr{´0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÁDVÖ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÁDìôHr`^tDVÖD“0Hr{´0......Phase 3A@..DVòDWŒ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161336101613361016DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŒDWóDVò AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDílHr`^ìDW×D§XHsÎ™ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DWÃDW×.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDílHr`^ìDVÖD“¨Hr{´¨DWÃDœÌHs´1LDW×D§XHsÎ™ØPhase 3A@..DVòDWŒ12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1016 10161336101613361016.DVòB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŒDWóDVò AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDílHr`^ìDW×D§XHsÎ™ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DWÃDW×.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDílHr`^ìDVÖD“¨Hr{´¨DWÃDœÌHs´1LDW×D§XHsÎ™ØPhase 3A@..DVòDWŒ12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1016 10161336101613361016DWÃDWÃC0REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŒDWóDVò AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDílHr`^ìDW×D§XHsÎ™ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DWÃDW×.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDílHr`^ìDVÖD“¨Hr{´¨DWÃDœÌHs´1LDW×D§XHsÎ™ØPhase 3A@..DVòDWŒ12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1016 10161336101613361016.DWóC0OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVòDWŒDWóDVòYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDílHr`^ìDW×D§XHsÎ™ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÖ.DWÃDW×.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDílHr`^ìDVÖD“¨Hr{´¨DWÃDœÌHs´1LDW×D§XHsÎ™ØPhase 3A@..DVòDWŒ12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1016 10161337101613371016DVÁDVÁASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVò.DW§DVò AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDèDHr`YÄDWŠDæÜHsiUÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÕ.DWuDWŠ.DWYPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDèDHr`YÄDVÕDå°Hrzµ0DWuDä„HsM¤DWŠDæÜHsiUÜPhase 3A@..DVò.12-15 YearsA YNN. DWXDWýDWýAðYEARSDSAC4591001C4591001 1016 10161337101613371016.DVòB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVò.DW§DVò AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDèDHr`YÄDWŠDæÜHsiUÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÕ.DWuDWŠ.DWYPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDèDHr`YÄDVÕDå°Hrzµ0DWuDä„HsM¤DWŠDæÜHsiUÜPhase 3A@..DVò.12-15 YearsA YNN. DWXDWýDWýAðYEARSDSA C4591001C4591001 1016 10161337101613371016DWuDWuBµREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVò.DW§DVò AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDèDHr`YÄDWŠDæÜHsiUÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÕ.DWuDWŠ.DWYPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDèDHr`YÄDVÕDå°Hrzµ0DWuDä„HsM¤DWŠDæÜHsiUÜPhase 3A@..DVò.12-15 YearsA YNN. DWXDWýDWýAðYEARSDSA0C4591001C4591001 1016 10161337101613371016.DW§BçOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVò.DW§DVòYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÁDèDHr`YÄDWŠDæÜHsiUÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÁDVÕ.DWuDWŠ.DWYPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÁDèDHr`YÄDVÕDå°Hrzµ0DWuDä„HsM¤DWŠDæÜHsiUÜPhase 3A@..DVò.12-15 YearsA YNN. DWXDWýDWýAðYEARSDSA@C4591001C4591001 1016 10161338101613381016DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW„.DW AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂDŽøHraQøDVÕDœHrzk˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVÕ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂDŽøHraQøDVÕDœHrzk˜......Phase 3A@..DWDW„12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161338101613381016.DWBDVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW„.DW AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂDŽøHraQøDVÕDœHrzk˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVÕ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂDŽøHraQøDVÕDœHrzk˜......Phase 3A@..DWDW„12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161339101613391016DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVòDW….DVò AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂD›(Hra^(DVÕD`Hrz_àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVÕ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂD›(Hra^(DVÕD`Hrz_à......Phase 3A@..DVòDW…12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161339101613391016.DVòB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVòDW….DVò AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂD›(Hra^(DVÕD`Hrz_àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVÕ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂD›(Hra^(DVÕD`Hrz_à......Phase 3A@..DVòDW…12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161340101613401016DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVòDW…DWÐDVò AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD›dHra^dDW®D†ÄHs˜kÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÕ.DWšDW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂD›dHra^dDVÕD$Hrz_¤DWšDŠüHs~üDW®D†ÄHs˜kÄPhase 3A@..DVòDW…12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161340101613401016.DVòB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVòDW…DWÐDVò AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD›dHra^dDW®D†ÄHs˜kÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÕ.DWšDW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂD›dHra^dDVÕD$Hrz_¤DWšDŠüHs~üDW®D†ÄHs˜kÄPhase 3A@..DVòDW…12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161340101613401016DWšDWšBÙREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVòDW…DWÐDVò AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD›dHra^dDW®D†ÄHs˜kÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÕ.DWšDW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂD›dHra^dDVÕD$Hrz_¤DWšDŠüHs~üDW®D†ÄHs˜kÄPhase 3A@..DVòDW…12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161340101613401016.DWÐCðOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVòDW…DWÐDVòYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂD›dHra^dDW®D†ÄHs˜kÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÕ.DWšDW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂD›dHra^dDVÕD$Hrz_¤DWšDŠüHs~üDW®D†ÄHs˜kÄPhase 3A@..DVòDW…12-15 YearsAYYNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161343101613431016DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVôDW‹.DVô AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂDê$Hra$DVØDÆÀHr~ŠÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVØ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂDê$Hra$DVØDÆÀHr~ŠÀ......Phase 3A@..DVôDW‹12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1016 10161343101613431016.DVôB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVôDW‹.DVô AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÂDê$Hra$DVØDÆÀHr~ŠÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÂDVØ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÂDê$Hra$DVØDÆÀHr~ŠÀ......Phase 3A@..DVôDW‹12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1016 10161344101613441016DVÂDVÂASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†DWÂDVó AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDëPHra®PDW¦Då°HsŽ>°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÖ.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂDëPHra®PDVÖDÛœHr{üœDW“D‹°HstØ0DW¦Då°HsŽ>°Phase 3A@..DVóDW†12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1016 10161344101613441016.DVóB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†DWÂDVó AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDëPHra®PDW¦Då°HsŽ>°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÖ.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂDëPHra®PDVÖDÛœHr{üœDW“D‹°HstØ0DW¦Då°HsŽ>°Phase 3A@..DVóDW†12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1016 10161344101613441016DW“DW“BÒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†DWÂDVó AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDëPHra®PDW¦Då°HsŽ>°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÖ.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂDëPHra®PDVÖDÛœHr{üœDW“D‹°HstØ0DW¦Då°HsŽ>°Phase 3A@..DVóDW†12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1016 10161344101613441016.DWÂCOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DVóDW†DWÂDVóYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÂDëPHra®PDW¦Då°HsŽ>°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÂDVÖ.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÂDëPHra®PDVÖDÛœHr{üœDW“D‹°HstØ0DW¦Då°HsŽ>°Phase 3A@..DVóDW†12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1016 10161350101613501016DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD“¨Hr”Á(DVþD ŒHr°}ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD“¨Hr”Á(DVþD ŒHr°}Œ......Phase 3A@..DWDW®12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1016 10161350101613501016.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéD“¨Hr”Á(DVþD ŒHr°}ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéD“¨Hr”Á(DVþD ŒHr°}Œ......Phase 3A@..DWDW®12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1016 10161351101613511016DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWåDW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéD’Hr”¿„DWÉD… Hs¼ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DWDWÉ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéD’Hr”¿„DVþDŒÜHr°iÜDWDŽ€Hs—"DWÉD… Hs¼ Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1016 10161351101613511016.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWåDW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéD’Hr”¿„DWÉD… Hs¼ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DWDWÉ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéD’Hr”¿„DVþDŒÜHr°iÜDWDŽ€Hs—"DWÉD… Hs¼ Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1016 10161351101613511016DWDWBÅREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWåDW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéD’Hr”¿„DWÉD… Hs¼ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DWDWÉ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéD’Hr”¿„DVþDŒÜHr°iÜDWDŽ€Hs—"DWÉD… Hs¼ Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1016 10161351101613511016.DWåBýOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWåDWYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéD’Hr”¿„DWÉD… Hs¼ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DWDWÉ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéD’Hr”¿„DVþDŒÜHr°iÜDWDŽ€Hs—"DWÉD… Hs¼ Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1016 10161352101613521016DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDÞlHr•ìDW´D¨Hs vPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW DW´.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDÞlHr•ìDVþDÍŒHr°ªŒDW D‹8Hs…û8DW´D¨Hs vPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1016 10161352101613521016.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDÞlHr•ìDW´D¨Hs vPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW DW´.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDÞlHr•ìDVþDÍŒHr°ªŒDW D‹8Hs…û8DW´D¨Hs vPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1016 10161352101613521016DW DW B¸REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDÞlHr•ìDW´D¨Hs vPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW DW´.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDÞlHr•ìDVþDÍŒHr°ªŒDW D‹8Hs…û8DW´D¨Hs vPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1016 10161352101613521016.DWÐBèOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÐDWYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDÞlHr•ìDW´D¨Hs vPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW DW´.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDÞlHr•ìDVþDÍŒHr°ªŒDW D‹8Hs…û8DW´D¨Hs vPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1016 10161353101613531016DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDè¼Hr•<DWD—,Hs—*¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDW.DW˜DW.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDè¼Hr•<DWD” Hr³ DW˜DèHs{ÌDWD—,Hs—*¬Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161353101613531016.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDè¼Hr•<DWD—,Hs—*¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDW.DW˜DW.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDè¼Hr•<DWD” Hr³ DW˜DèHs{ÌDWD—,Hs—*¬Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161353101613531016DW˜DW˜B°REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDè¼Hr•<DWD—,Hs—*¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDW.DW˜DW.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDè¼Hr•<DWD” Hr³ DW˜DèHs{ÌDWD—,Hs—*¬Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1016 10161353101613531016.DWÉBáOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDWYAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDè¼Hr•<DWD—,Hs—*¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDW.DW˜DW.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDè¼Hr•<DWD” Hr³ DW˜DèHs{ÌDWD—,Hs—*¬Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1016 10161354101613541016DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW·.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDŽ€Hr—_DWDˆàHr³àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDŽ€Hr—_DWDˆàHr³à......Phase 3A@..DWDW·12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1016 10161354101613541016.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW·.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDŽ€Hr—_DWDˆàHr³àBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDŽ€Hr—_DWDˆàHr³à......Phase 3A@..DWDW·12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1016 10161356101613561016DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD›(Hr—k¨DVÿDpHr±½ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD›(Hr—k¨DVÿDpHr±½ð......Phase 3A@..DWDW°12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161356101613561016.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD›(Hr—k¨DVÿDpHr±½ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD›(Hr—k¨DVÿDpHr±½ð......Phase 3A@..DWDW°12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161357101613571016DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD¢0Hr—r°DVÿD•LHr±ÃÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD¢0Hr—r°DVÿD•LHr±ÃÌ......Phase 3A@..DWDW®12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161357101613571016.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD¢0Hr—r°DVÿD•LHr±ÃÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD¢0Hr—r°DVÿD•LHr±ÃÌ......Phase 3A@..DWDW®12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161358101613581016DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD‰Hr˜«DVÿDÊ€Hr±ùPlacebo Placebo 12-15 YearsA . . .DVìDVÿ.....Placebo Placebo Placebo A .Placebo A .DVìD‰Hr˜«DVÿDÊ€Hr±ù......Phase 3A@..DWDWµ12-15 YearsA YNN. DWý.DWýAÐYEARSDSAC4591001C4591001 1016 10161358101613581016.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD‰Hr˜«DVÿDÊ€Hr±ùPlacebo Placebo 12-15 YearsA . . .DVìDVÿ.....Placebo Placebo Placebo A .Placebo A .DVìD‰Hr˜«DVÿDÊ€Hr±ù......Phase 3A@..DWDWµ12-15 YearsA YNN. DWý.DWýAÐYEARSDSA C4591001C4591001 1016 10161361101613611016DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÂDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD“lHršìDW¦DÐ HsŽ) Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD“lHršìDWD™Hr³DW‘DÁ\HsrjÜDW¦DÐ HsŽ) Phase 3A@..DW.12-15 YearsAYYNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161361101613611016.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÂDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD“lHršìDW¦DÐ HsŽ) Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD“lHršìDWD™Hr³DW‘DÁ\HsrjÜDW¦DÐ HsŽ) Phase 3A@..DW.12-15 YearsAYYNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161361101613611016DW‘DW‘B¥REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÂDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD“lHršìDW¦DÐ HsŽ) Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD“lHršìDWD™Hr³DW‘DÁ\HsrjÜDW¦DÐ HsŽ) Phase 3A@..DW.12-15 YearsAYYNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1016 10161361101613611016.DWÂBÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÂDWYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD“lHršìDW¦DÐ HsŽ) Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD“lHršìDWD™Hr³DW‘DÁ\HsrjÜDW¦DÐ HsŽ) Phase 3A@..DW.12-15 YearsAYYNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1016 10161362101613621016DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¶.DW" AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDÛØHršOXDWDÍÈHr¹åHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDÛØHršOXDWDÍÈHr¹åH......Phase 3A@..DW"DW¶12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161362101613621016.DW"B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¶.DW" AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDÛØHršOXDWDÍÈHr¹åHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDÛØHršOXDWDÍÈHr¹åH......Phase 3A@..DW"DW¶12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161363101613631016DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¶.DW" AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDâ¤HrŸœ$DWDÖtHr¹íôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDâ¤HrŸœ$DWDÖtHr¹íô......Phase 3A@..DW"DW¶12-15 YearsAYYNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1016 10161363101613631016.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DW¶.DW" AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDâ¤HrŸœ$DWDÖtHr¹íôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDâ¤HrŸœ$DWDÖtHr¹íô......Phase 3A@..DW"DW¶12-15 YearsAYYNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1016 10161364101613641016DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW».DW+ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÚèHr åèDWDHr½©BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŠBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÚèHr åèDWDHr½©......Phase 3A@..DW+DW»12-15 YearsAYYNY. DW‰DWýDWýAðYEARSDSAC4591001C4591001 1016 10161364101613641016.DW+B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW».DW+ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÚèHr åèDWDHr½©BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŠBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÚèHr åèDWDHr½©......Phase 3A@..DW+DW»12-15 YearsAYYNY. DW‰DWýDWýAðYEARSDSA C4591001C4591001 1016 10161365101613651016DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AÐYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVóD¤ˆHr¢DW©DœHs‘ÞPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD¤ˆHr¢DWDŒ(Hrºõ(DW‘DÔ”Hsr~DW©DœHs‘ÞPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161365101613651016.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AÐYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVóD¤ˆHr¢DW©DœHs‘ÞPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD¤ˆHr¢DWDŒ(Hrºõ(DW‘DÔ”Hsr~DW©DœHs‘ÞPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161365101613651016DW‘DW‘BŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AÐYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVóD¤ˆHr¢DW©DœHs‘ÞPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD¤ˆHr¢DWDŒ(Hrºõ(DW‘DÔ”Hsr~DW©DœHs‘ÞPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1016 10161365101613651016.DWÅBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW#YAÐYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVóD¤ˆHr¢DW©DœHs‘ÞPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD¤ˆHr¢DWDŒ(Hrºõ(DW‘DÔ”Hsr~DW©DœHs‘ÞPhase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1016 10161366101613661016DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWæDW8 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÛØHr¨ÏØDWÄDÙ€Hsµ¿€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW“DWÄ.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÛØHr¨ÏØDWDëPHrÇ1ÐDW“DçHsu3˜DWÄDÙ€Hsµ¿€Phase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161366101613661016.DW8BAVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWæDW8 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÛØHr¨ÏØDWÄDÙ€Hsµ¿€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW“DWÄ.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÛØHr¨ÏØDWDëPHrÇ1ÐDW“DçHsu3˜DWÄDÙ€Hsµ¿€Phase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161366101613661016DW“DW“BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWæDW8 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÛØHr¨ÏØDWÄDÙ€Hsµ¿€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW“DWÄ.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÛØHr¨ÏØDWDëPHrÇ1ÐDW“DçHsu3˜DWÄDÙ€Hsµ¿€Phase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161366101613661016.DWæBïOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWæDW8YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÛØHr¨ÏØDWÄDÙ€Hsµ¿€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW“DWÄ.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÛØHr¨ÏØDWDëPHrÇ1ÐDW“DçHsu3˜DWÄDÙ€Hsµ¿€Phase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161367101613671016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW= AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD™üHr»üDWD«Hs—>˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™üHr»üDWD›dHrÖ³äDW˜DÌ`Hs{°`DWD«Hs—>˜Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161367101613671016.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW= AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD™üHr»üDWD«Hs—>˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™üHr»üDWD›dHrÖ³äDW˜DÌ`Hs{°`DWD«Hs—>˜Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161367101613671016DW˜DW˜B“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW= AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD™üHr»üDWD«Hs—>˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™üHr»üDWD›dHrÖ³äDW˜DÌ`Hs{°`DWD«Hs—>˜Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161367101613671016.DWÉBÄOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW=YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD™üHr»üDWD«Hs—>˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™üHr»üDWD›dHrÖ³äDW˜DÌ`Hs{°`DWD«Hs—>˜Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161368101613681016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÄDW: AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáxHr¼›øDW¨Dè¼Hsä¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáxHr¼›øDWDÔÐHrÖíPDW“DÛ`Hsu'àDW¨Dè¼Hsä¼Phase 3A@..DW:.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161368101613681016.DW:B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÄDW: AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáxHr¼›øDW¨Dè¼Hsä¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáxHr¼›øDWDÔÐHrÖíPDW“DÛ`Hsu'àDW¨Dè¼Hsä¼Phase 3A@..DW:.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161368101613681016DW“DW“BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÄDW: AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáxHr¼›øDW¨Dè¼Hsä¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáxHr¼›øDWDÔÐHrÖíPDW“DÛ`Hsu'àDW¨Dè¼Hsä¼Phase 3A@..DW:.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161368101613681016.DWÄB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÄDW:YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáxHr¼›øDW¨Dè¼Hsä¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáxHr¼›øDWDÔÐHrÖíPDW“DÛ`Hsu'àDW¨Dè¼Hsä¼Phase 3A@..DW:.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161369101613691016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÔ.DWF AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDå8Hr¼Ÿ¸DW#DáxHrá…øBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDå8Hr¼Ÿ¸DW#DáxHrá…ø......Phase 3A@..DWFDWÔ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161369101613691016.DWFB@VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÔ.DWF AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDå8Hr¼Ÿ¸DW#DáxHrá…øBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDå8Hr¼Ÿ¸DW#DáxHrá…ø......Phase 3A@..DWFDWÔ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161370101613701016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD£\HrÂõ\DW!DèøHrÞêxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD£\HrÂõ\DW!DèøHrÞêx......Phase 3A@..DWADWÙ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1016 10161370101613701016.DWAB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD£\HrÂõ\DW!DèøHrÞêxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD£\HrÂõ\DW!DèøHrÞêx......Phase 3A@..DWADWÙ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1016 10161371101613711016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÚèHrÃ,èDWDæ(Hs—y¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW™DW.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÚèHrÃ,èDW"DÝôHrà0ôDW™DÜŒHs}DWDæ(Hs—y¨Phase 3A@..DW>.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161371101613711016.DW>B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÚèHrÃ,èDWDæ(Hs—y¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW™DW.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÚèHrÃ,èDW"DÝôHrà0ôDW™DÜŒHs}DWDæ(Hs—y¨Phase 3A@..DW>.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161371101613711016DW™DW™BŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÚèHrÃ,èDWDæ(Hs—y¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW™DW.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÚèHrÃ,èDW"DÝôHrà0ôDW™DÜŒHs}DWDæ(Hs—y¨Phase 3A@..DW>.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161371101613711016.DWÉB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW>YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÚèHrÃ,èDWDæ(Hs—y¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW™DW.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÚèHrÃ,èDW"DÝôHrà0ôDW™DÜŒHs}DWDæ(Hs—y¨Phase 3A@..DW>.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161372101613721016DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¾DW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÞäHrÄ‚dDW¢DÞ¨Hsˆñ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW#.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÞäHrÄ‚dDW#DáHrá…€DWDæ(HsmI¨DW¢DÞ¨Hsˆñ¨Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1016 10161372101613721016.DW@B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¾DW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÞäHrÄ‚dDW¢DÞ¨Hsˆñ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW#.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÞäHrÄ‚dDW#DáHrá…€DWDæ(HsmI¨DW¢DÞ¨Hsˆñ¨Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1016 10161372101613721016DWDWBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¾DW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÞäHrÄ‚dDW¢DÞ¨Hsˆñ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW#.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÞäHrÄ‚dDW#DáHrá…€DWDæ(HsmI¨DW¢DÞ¨Hsˆñ¨Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1016 10161372101613721016.DW¾B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¾DW@YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÞäHrÄ‚dDW¢DÞ¨Hsˆñ¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW#.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÞäHrÄ‚dDW#DáHrá…€DWDæ(HsmI¨DW¢DÞ¨Hsˆñ¨Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1016 10161373101613731016DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DçHrÄŠ˜DW#DHrá1˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DçHrÄŠ˜DW#DHrá1˜......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1016 10161373101613731016.DW?B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DçHrÄŠ˜DW#DHrá1˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DçHrÄŠ˜DW#DHrá1˜......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1016 10161374101613741016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWà.DWA AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¯PHrÅ¤PDW$D¥<Hrâ›<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¯PHrÅ¤PDW$D¥<Hrâ›<......Phase 3A@..DWADWà12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161374101613741016.DWAB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWà.DWA AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¯PHrÅ¤PDW$D¥<Hrâ›<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¯PHrÅ¤PDW$D¥<Hrâ›<......Phase 3A@..DWADWà12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161375101613751016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâàHrÅ×àDW¦Dš°Hsó°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâàHrÅ×àDW#Dß˜Hrá„DW‘DëPHsr”ÐDW¦Dš°Hsó°Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1016 10161375101613751016.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâàHrÅ×àDW¦Dš°Hsó°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâàHrÅ×àDW#Dß˜Hrá„DW‘DëPHsr”ÐDW¦Dš°Hsó°Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1016 10161375101613751016DW‘DW‘B„REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâàHrÅ×àDW¦Dš°Hsó°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâàHrÅ×àDW#Dß˜Hrá„DW‘DëPHsr”ÐDW¦Dš°Hsó°Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1016 10161375101613751016.DWÃB¶OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW?YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâàHrÅ×àDW¦Dš°Hsó°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâàHrÅ×àDW#Dß˜Hrá„DW‘DëPHsr”ÐDW¦Dš°Hsó°Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1016 10161376101613761016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DW×.DW> AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD©°HrÆð0DW"D¡¸Hrßô¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWƒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD©°HrÆð0DW"D¡¸Hrßô¸......Phase 3A@..DW>DW×12-15 YearsA YNY. DW‚DWýDWýAðYEARSDSAC4591001C4591001 1016 10161376101613761016.DW>B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DW×.DW> AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD©°HrÆð0DW"D¡¸Hrßô¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWƒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD©°HrÆð0DW"D¡¸Hrßô¸......Phase 3A@..DW>DW×12-15 YearsA YNY. DW‚DWýDWýAðYEARSDSA C4591001C4591001 1016 10161377101613771016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DW×.DW> AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD©ìHrÆðlDW"D¢0Hrßõ0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD©ìHrÆðlDW"D¢0Hrßõ0......Phase 3A@..DW>DW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161377101613771016.DW>B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DW×.DW> AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD©ìHrÆðlDW"D¢0Hrßõ0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD©ìHrÆðlDW"D¢0Hrßõ0......Phase 3A@..DW>DW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161378101613781016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÔ.DW> AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâhHrÇ(èDWõDæÜHsöf\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWàDWõ.DW×Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâhHrÇ(èDW"DèDHrà;DDWàDèDHsÚ¸DDWõDæÜHsöf\Phase 3A@..DW>DWÔ12-15 YearsA YNN. DWÖDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161378101613781016.DW>B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÔ.DW> AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâhHrÇ(èDWõDæÜHsöf\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWàDWõ.DW×Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâhHrÇ(èDW"DèDHrà;DDWàDèDHsÚ¸DDWõDæÜHsöf\Phase 3A@..DW>DWÔ12-15 YearsA YNN. DWÖDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161378101613781016DWàDWàBÒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÔ.DW> AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâhHrÇ(èDWõDæÜHsöf\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWàDWõ.DW×Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâhHrÇ(èDW"DèDHrà;DDWàDèDHsÚ¸DDWõDæÜHsöf\Phase 3A@..DW>DWÔ12-15 YearsA YNN. DWÖDWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161379101613791016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWM.DWÙDWM AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDì|HrÇ2üDW»D“¨Hs©œ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DW DW».DWŽPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDì|HrÇ2üDWDì|HrÇ2üDW D¬¼Hs†¼DW»D“¨Hs©œ(Phase 3A@.DW,DWM.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161379101613791016DW DW B’REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWM.DWÙDWM AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDì|HrÇ2üDW»D“¨Hs©œ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DW DW».DWŽPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDì|HrÇ2üDWDì|HrÇ2üDW D¬¼Hs†¼DW»D“¨Hs©œ(Phase 3A@.DW,DWM.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161379101613791016.DWÙBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWM.DWÙDWMYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDì|HrÇ2üDW»D“¨Hs©œ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DW DW».DWŽPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDì|HrÇ2üDWDì|HrÇ2üDW D¬¼Hs†¼DW»D“¨Hs©œ(Phase 3A@.DW,DWM.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1016 10161379101613791016.DW,BVACCINATION BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABsubject with positive covid test DWM.DWÙDWM AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDì|HrÇ2üDW»D“¨Hs©œ(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW..DW DW».DWŽPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDì|HrÇ2üDWDì|HrÇ2üDW D¬¼Hs†¼DW»D“¨Hs©œ(Phase 3A@.DW,DWM.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA`C4591001C4591001 1016 10161381101613811016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWà.DW@ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD–HrÈ.DW$DŸœHrâ•œBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD–HrÈ.DW$DŸœHrâ•œ......Phase 3A@..DW@DWà12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1016 10161381101613811016.DW@B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWà.DW@ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD–HrÈ.DW$DŸœHrâ•œBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD–HrÈ.DW$DŸœHrâ•œ......Phase 3A@..DW@DWà12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1016 10161382101613821016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDštHrÈ2tDW$DÛ$HrâÑ$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDštHrÈ2tDW$DÛ$HrâÑ$......Phase 3A@..DWADW×12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161382101613821016.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDštHrÈ2tDW$DÛ$HrâÑ$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDštHrÈ2tDW$DÛ$HrâÑ$......Phase 3A@..DWADW×12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161383101613831016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW½DWA AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD™ÀHrÈ1ÀDW Dš°Hs† °Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™ÀHrÈ1ÀDW$DÚèHrâÐèDWDÙ€Hsm=DW Dš°Hs† °Phase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1016 10161383101613831016.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW½DWA AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD™ÀHrÈ1ÀDW Dš°Hs† °Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™ÀHrÈ1ÀDW$DÚèHrâÐèDWDÙ€Hsm=DW Dš°Hs† °Phase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1016 10161383101613831016DWDWB~REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW½DWA AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD™ÀHrÈ1ÀDW Dš°Hs† °Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™ÀHrÈ1ÀDW$DÚèHrâÐèDWDÙ€Hsm=DW Dš°Hs† °Phase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1016 10161383101613831016.DW½B®OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW½DWAYAÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD™ÀHrÈ1ÀDW Dš°Hs† °Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD™ÀHrÈ1ÀDW$DÚèHrâÐèDWDÙ€Hsm=DW Dš°Hs† °Phase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1016 10161384101613841016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DW×.DW? AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD HrÈ8DW#Dè€HráBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD HrÈ8DW#Dè€Hrá......Phase 3A@..DW?DW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161384101613841016.DW?B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DW×.DW? AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD HrÈ8DW#Dè€HráBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD HrÈ8DW#Dè€Hrá......Phase 3A@..DW?DW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161385101613851016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDÒðHrÈjðDW%D„¨HrãÌ(Placebo Placebo 12-15 YearsA . . .DWDW%.....Placebo Placebo Placebo A .Placebo A .DWDÒðHrÈjðDW%D„¨HrãÌ(......Phase 3A@..DWADWÞ12-15 YearsA YNN. DWý.DWýAàYEARSDSAC4591001C4591001 1016 10161385101613851016.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDÒðHrÈjðDW%D„¨HrãÌ(Placebo Placebo 12-15 YearsA . . .DWDW%.....Placebo Placebo Placebo A .Placebo A .DWDÒðHrÈjðDW%D„¨HrãÌ(......Phase 3A@..DWADWÞ12-15 YearsA YNN. DWý.DWýAàYEARSDSA C4591001C4591001 1016 10161386101613861016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¼DW@ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDØÌHrÈpÌDW DÉHs†9Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDØÌHrÈpÌDW$D¤HrâšDWDòXHsmUØDW DÉHs†9Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1016 10161386101613861016.DW@B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¼DW@ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDØÌHrÈpÌDW DÉHs†9Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDØÌHrÈpÌDW$D¤HrâšDWDòXHsmUØDW DÉHs†9Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1016 10161386101613861016DWDWB~REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¼DW@ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDØÌHrÈpÌDW DÉHs†9Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDØÌHrÈpÌDW$D¤HrâšDWDòXHsmUØDW DÉHs†9Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1016 10161386101613861016.DW¼BOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DW¼DW@YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDØÌHrÈpÌDW DÉHs†9Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDØÌHrÈpÌDW$D¤HrâšDWDòXHsmUØDW DÉHs†9Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1016 10161387101613871016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDâhHrÈzhDW#DÔÐHráyPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDâhHrÈzhDW#DÔÐHráyP......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1016 10161387101613871016.DW?B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDâhHrÈzhDW#DÔÐHráyPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDâhHrÈzhDW#DÔÐHráyP......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1016 10161388101613881016DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW´DWE AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDäHHrÌpÈDW˜DÌHs{qÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW…DW˜.DWƒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDäHHrÌpÈDW)DÉHréWDW…D“lHsbjìDW˜DÌHs{qÌPhase 3A@..DWE.12-15 YearsA YNN. DW‚DWýDWýAðYEARSDSAC4591001C4591001 1016 10161388101613881016.DWEB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW´DWE AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDäHHrÌpÈDW˜DÌHs{qÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW…DW˜.DWƒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDäHHrÌpÈDW)DÉHréWDW…D“lHsbjìDW˜DÌHs{qÌPhase 3A@..DWE.12-15 YearsA YNN. DW‚DWýDWýAðYEARSDSA C4591001C4591001 1016 10161388101613881016DW…DW…BsREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW´DWE AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDäHHrÌpÈDW˜DÌHs{qÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW…DW˜.DWƒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDäHHrÌpÈDW)DÉHréWDW…D“lHsbjìDW˜DÌHs{qÌPhase 3A@..DWE.12-15 YearsA YNN. DW‚DWýDWýAðYEARSDSA0C4591001C4591001 1016 10161388101613881016.DW´B¢OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW´DWEYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDäHHrÌpÈDW˜DÌHs{qÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW…DW˜.DWƒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDäHHrÌpÈDW)DÉHréWDW…D“lHsbjìDW˜DÌHs{qÌPhase 3A@..DWE.12-15 YearsA YNN. DW‚DWýDWýAðYEARSDSA@C4591001C4591001 1039 10391246103912461039DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWqDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD~THr•ýTDWUDš°Hs#*0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DWADWU.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD~THr•ýTDVþD‚Hr°_DWADm°HsŸ0DWUDš°Hs#*0Phase 3A@..DW.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSAC4591001C4591001 1039 10391246103912461039.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWqDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD~THr•ýTDWUDš°Hs#*0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DWADWU.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD~THr•ýTDVþD‚Hr°_DWADm°HsŸ0DWUDš°Hs#*0Phase 3A@..DW.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA C4591001C4591001 1039 10391246103912461039DWADWABXREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWqDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD~THr•ýTDWUDš°Hs#*0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DWADWU.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD~THr•ýTDVþD‚Hr°_DWADm°HsŸ0DWUDš°Hs#*0Phase 3A@..DW.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA0C4591001C4591001 1039 10391246103912461039.DWqBˆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWqDWYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD~THr•ýTDWUDš°Hs#*0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DWADWU.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD~THr•ýTDVþD‚Hr°_DWADm°HsŸ0DWUDš°Hs#*0Phase 3A@..DW.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA@C4591001C4591001 1039 10391247103912471039DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêD€¬Hr•ÿ¬DVþD‚ŒHr°_ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVþ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêD€¬Hr•ÿ¬DVþD‚ŒHr°_Œ......Phase 3A@..DWDW12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391247103912471039.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêD€¬Hr•ÿ¬DVþD‚ŒHr°_ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVþ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêD€¬Hr•ÿ¬DVþD‚ŒHr°_Œ......Phase 3A@..DWDW12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391250103912501039DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DWÃ.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD†ˆHr™úDWDwHr¹ŽBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD†ˆHr™úDWDwHr¹Ž......Phase 3A@..DW#DWÃ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1039 10391250103912501039.DW#B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWÃ.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD†ˆHr™úDWDwHr¹ŽBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD†ˆHr™úDWDwHr¹Ž......Phase 3A@..DW#DWÃ12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1039 10391251103912511039DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DW\DW) AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDsHrÛDW@DlÀHsLÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW)DW@.DW)Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDsHrÛDWDqèHrÂÃèDW)DwHréDW@DlÀHsLÀPhase 3A@..DW).12-15 YearsA YNN. DW(DWýDWýAðYEARSDSAC4591001C4591001 1039 10391251103912511039DW)DW)B:REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW\DW) AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDsHrÛDW@DlÀHsLÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW)DW@.DW)Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDsHrÛDWDqèHrÂÃèDW)DwHréDW@DlÀHsLÀPhase 3A@..DW).12-15 YearsA YNN. DW(DWýDWýAðYEARSDSA C4591001C4591001 1039 10391251103912511039.DW)B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW\DW) AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDsHrÛDW@DlÀHsLÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW)DW@.DW)Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDsHrÛDWDqèHrÂÃèDW)DwHréDW@DlÀHsLÀPhase 3A@..DW).12-15 YearsA YNN. DW(DWýDWýAðYEARSDSA0C4591001C4591001 1039 10391251103912511039.DW\BmOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW\DW)YAðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDsHrÛDW@DlÀHsLÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW)DW@.DW)Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDsHrÛDWDqèHrÂÃèDW)DwHréDW@DlÀHsLÀPhase 3A@..DW).12-15 YearsA YNN. DW(DWýDWýAðYEARSDSA@C4591001C4591001 1039 10391252103912521039DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWŽDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDxHràDWqDÃ<HsH<¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW\DWq.DWVPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDxHràDWD¼Hr¹µ<DW\DÄàHs,ŽàDWqDÃ<HsH<¼Phase 3A@..DW#.12-15 YearsA YNN. DWUDWýDWýAðYEARSDSAC4591001C4591001 1039 10391252103912521039.DW#B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWŽDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDxHràDWqDÃ<HsH<¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW\DWq.DWVPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDxHràDWD¼Hr¹µ<DW\DÄàHs,ŽàDWqDÃ<HsH<¼Phase 3A@..DW#.12-15 YearsA YNN. DWUDWýDWýAðYEARSDSA C4591001C4591001 1039 10391252103912521039DW\DW\BmREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWŽDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDxHràDWqDÃ<HsH<¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW\DWq.DWVPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDxHràDWD¼Hr¹µ<DW\DÄàHs,ŽàDWqDÃ<HsH<¼Phase 3A@..DW#.12-15 YearsA YNN. DWUDWýDWýAðYEARSDSA0C4591001C4591001 1039 10391252103912521039.DWŽBŸOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWŽDW#YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDxHràDWqDÃ<HsH<¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW\DWq.DWVPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDxHràDWD¼Hr¹µ<DW\DÄàHs,ŽàDWqDÃ<HsH<¼Phase 3A@..DW#.12-15 YearsA YNN. DWUDWýDWýAðYEARSDSA@C4591001C4591001 1039 10391253103912531039DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#..DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD$Hré$DWDž4Hr¹µ´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD$Hré$DWDž4Hr¹µ´......Phase 3A@DWå.DW#.12-15 YearsA YNY. DW‹DWåDWåAÀYEARSDSAC4591001C4591001 1039 10391253103912531039.DW#B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#..DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD$Hré$DWDž4Hr¹µ´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD$Hré$DWDž4Hr¹µ´......Phase 3A@DWå.DW#.12-15 YearsA YNY. DW‹DWåDWåAÀYEARSDSA C4591001C4591001 1039 10391253103912531039.DWåBöFOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APSubject lost to follow up DW#..DW#YAÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD$Hré$DWDž4Hr¹µ´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD$Hré$DWDž4Hr¹µ´......Phase 3A@DWå.DW#.12-15 YearsA YNY. DW‹DWåDWåAÀYEARSDSAPC4591001C4591001 1039 10391255103912551039DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DWÉ.DW# AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD©°Hrž°DWD¡Hr» BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD©°Hrž°DWD¡Hr» ......Phase 3A@..DW#DWÉ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391255103912551039.DW#B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWÉ.DW# AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD©°Hrž°DWD¡Hr» BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD©°Hrž°DWD¡Hr» ......Phase 3A@..DW#DWÉ12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391256103912561039DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¾DW# AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD´<Hrž<DW¢D¯ÈHsˆÂÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD´<Hrž<DWD Hr» DWD·üHsm|DW¢D¯ÈHsˆÂÈPhase 3A@..DW#.12-15 YearsAYYNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391256103912561039.DW#B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¾DW# AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD´<Hrž<DW¢D¯ÈHsˆÂÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD´<Hrž<DWD Hr» DWD·üHsm|DW¢D¯ÈHsˆÂÈPhase 3A@..DW#.12-15 YearsAYYNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391256103912561039DWDWBžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¾DW# AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD´<Hrž<DW¢D¯ÈHsˆÂÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD´<Hrž<DWD Hr» DWD·üHsm|DW¢D¯ÈHsˆÂÈPhase 3A@..DW#.12-15 YearsAYYNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1039 10391256103912561039.DW¾BÏOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¾DW#YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD´<Hrž<DW¢D¯ÈHsˆÂÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD´<Hrž<DWD Hr» DWD·üHsm|DW¢D¯ÈHsˆÂÈPhase 3A@..DW#.12-15 YearsAYYNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1039 10391258103912581039DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÃDW$ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD² Hrž DW D©8Hs†8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW .DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD² Hrž DWD±¨Hr¹É(DWDµ¤Hsm$DW D©8Hs†8Phase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1039 10391258103912581039.DW$B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÃDW$ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD² Hrž DW D©8Hs†8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW .DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD² Hrž DWD±¨Hr¹É(DWDµ¤Hsm$DW D©8Hs†8Phase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1039 10391258103912581039DWDWBžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÃDW$ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD² Hrž DW D©8Hs†8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW .DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD² Hrž DWD±¨Hr¹É(DWDµ¤Hsm$DW D©8Hs†8Phase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391258103912581039.DWÃBÔOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÃDW$YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD² Hrž DW D©8Hs†8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW .DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD² Hrž DWD±¨Hr¹É(DWDµ¤Hsm$DW D©8Hs†8Phase 3A@..DW$.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391259103912591039DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW! AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¿ôHrž'ôDW£D¹dHsŠäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD¿ôHrž'ôDWD¤ˆHr¹¼DWŽDÃ<Hsnx<DW£D¹dHsŠäPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1039 10391259103912591039.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW! AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¿ôHrž'ôDW£D¹dHsŠäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD¿ôHrž'ôDWD¤ˆHr¹¼DWŽDÃ<Hsnx<DW£D¹dHsŠäPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1039 10391259103912591039DWŽDWŽBŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW! AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¿ôHrž'ôDW£D¹dHsŠäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD¿ôHrž'ôDWD¤ˆHr¹¼DWŽDÃ<Hsnx<DW£D¹dHsŠäPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391259103912591039.DW¿BÐOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW!YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¿ôHrž'ôDW£D¹dHsŠäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD¿ôHrž'ôDWD¤ˆHr¹¼DWŽDÃ<Hsnx<DW£D¹dHsŠäPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391260103912601039DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW».DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÉÌHrž1ÌDWDÅXHr¹ÜØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÉÌHrž1ÌDWDÅXHr¹ÜØ......Phase 3A@..DW!DW»12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1039 10391260103912601039.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW».DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÉÌHrž1ÌDWDÅXHr¹ÜØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÉÌHrž1ÌDWDÅXHr¹ÜØ......Phase 3A@..DW!DW»12-15 YearsA YNY. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1039 10391262103912621039DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DWµ.DW$ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDtôHrŸ.tDWDq4HrºÚ4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDtôHrŸ.tDWDq4HrºÚ4......Phase 3A@..DW$DWµ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1039 10391262103912621039.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DWµ.DW$ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDtôHrŸ.tDWDq4HrºÚ4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDtôHrŸ.tDWDq4HrºÚ4......Phase 3A@..DW$DWµ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1039 10391263103912631039DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DWµ.DW$ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDxðHrŸ2pDWDpHrºÙBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDxðHrŸ2pDWDpHrºÙ......Phase 3A@..DW$DWµ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391263103912631039.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DWµ.DW$ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDxðHrŸ2pDWDpHrºÙBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDxðHrŸ2pDWDpHrºÙ......Phase 3A@..DW$DWµ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391264103912641039DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD..DWD AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVñD§”HrŸaDW˜DÄhHs{¨hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW˜..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD§”HrŸaDWD¡Hr» DW˜DÄhHs{¨hDW˜DÄhHs{¨hPhase 3A@DW§.DWD.12-15 YearsA YNNDW§WITHDRAWAL BY SUBJECTDWŒDW§DW§AÀYEARSDSAC4591001C4591001 1039 10391264103912641039.DWDBTVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD..DWD AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVñD§”HrŸaDW˜DÄhHs{¨hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW˜..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD§”HrŸaDWD¡Hr» DW˜DÄhHs{¨hDW˜DÄhHs{¨hPhase 3A@DW§.DWD.12-15 YearsA YNNDW§WITHDRAWAL BY SUBJECTDWŒDW§DW§AÀYEARSDSA C4591001C4591001 1039 10391264103912641039DW˜DW˜B¨REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD..DWD AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVñD§”HrŸaDW˜DÄhHs{¨hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW˜..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD§”HrŸaDWD¡Hr» DW˜DÄhHs{¨hDW˜DÄhHs{¨hPhase 3A@DW§.DWD.12-15 YearsA YNNDW§WITHDRAWAL BY SUBJECTDWŒDW§DW§AÀYEARSDSA0C4591001C4591001 1039 10391264103912641039.DW§B·OPEN LABEL TREATMENTApDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject has withdrawn from study. DWD..DWDYAÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVñD§”HrŸaDW˜DÄhHs{¨hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW˜..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD§”HrŸaDWD¡Hr» DW˜DÄhHs{¨hDW˜DÄhHs{¨hPhase 3A@DW§.DWD.12-15 YearsA YNNDW§WITHDRAWAL BY SUBJECTDWŒDW§DW§AÀYEARSDSA€C4591001C4591001 1039 10391264103912641039.DW§B·FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject has withdrawn from study. DWD..DWDYAÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVñD§”HrŸaDW˜DÄhHs{¨hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW˜..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD§”HrŸaDWD¡Hr» DW˜DÄhHs{¨hDW˜DÄhHs{¨hPhase 3A@DW§.DWD.12-15 YearsA YNNDW§WITHDRAWAL BY SUBJECTDWŒDW§DW§AÀYEARSDSAC4591001C4591001 1039 10391265103912651039DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDW¼.DWD AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD«HrŸd˜DWD®ØHr»ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD«HrŸd˜DWD®ØHr»Ø......Phase 3A@..DWDDW¼12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391265103912651039.DWDBTVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDW¼.DWD AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD«HrŸd˜DWD®ØHr»ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD«HrŸd˜DWD®ØHr»Ø......Phase 3A@..DWDDW¼12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391266103912661039DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDºHrŸtDW¢DÅÐHsˆØÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDºHrŸtDWD˜XHr»XDWŽDÇ°Hsn|°DW¢DÅÐHsˆØÐPhase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391266103912661039.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDºHrŸtDW¢DÅÐHsˆØÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDºHrŸtDWD˜XHr»XDWŽDÇ°Hsn|°DW¢DÅÐHsˆØÐPhase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391266103912661039DWŽDWŽBžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDºHrŸtDW¢DÅÐHsˆØÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDºHrŸtDWD˜XHr»XDWŽDÇ°Hsn|°DW¢DÅÐHsˆØÐPhase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1039 10391266103912661039.DWÅBÕOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW"YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDºHrŸtDW¢DÅÐHsˆØÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWŽDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDºHrŸtDWD˜XHr»XDWŽDÇ°Hsn|°DW¢DÅÐHsˆØÐPhase 3A@..DW".12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1039 10391267103912671039DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¿.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÃxHrŸ|øDWD{ÀHr¹“@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWRBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÃxHrŸ|øDWD{ÀHr¹“@......Phase 3A@..DW!DW¿12-15 YearsA YNY. DWQDWýDWýAðYEARSDSAC4591001C4591001 1039 10391267103912671039.DW!B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¿.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÃxHrŸ|øDWD{ÀHr¹“@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWRBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÃxHrŸ|øDWD{ÀHr¹“@......Phase 3A@..DW!DW¿12-15 YearsA YNY. DWQDWýDWýAðYEARSDSA C4591001C4591001 1039 10391268103912681039DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD½ØHrŸwXDW£D¸ìHsŠlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD½ØHrŸwXDWDpHr¹‡ˆDWDŽøHslòxDW£D¸ìHsŠlPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1039 10391268103912681039.DW!B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD½ØHrŸwXDW£D¸ìHsŠlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD½ØHrŸwXDWDpHr¹‡ˆDWDŽøHslòxDW£D¸ìHsŠlPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1039 10391268103912681039DWDWBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD½ØHrŸwXDW£D¸ìHsŠlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD½ØHrŸwXDWDpHr¹‡ˆDWDŽøHslòxDW£D¸ìHsŠlPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391268103912681039.DW¿BÏOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¿DW!YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD½ØHrŸwXDW£D¸ìHsŠlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD½ØHrŸwXDWDpHr¹‡ˆDWDŽøHslòxDW£D¸ìHsŠlPhase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391269103912691039DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¿.DW! AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÀ¨HrŸz(DWDpøHr¹ˆxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÀ¨HrŸz(DWDpøHr¹ˆx......Phase 3A@..DW!DW¿12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391269103912691039.DW!B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¿.DW! AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÀ¨HrŸz(DWDpøHr¹ˆxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÀ¨HrŸz(DWDpøHr¹ˆx......Phase 3A@..DW!DW¿12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391270103912701039DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¡ôHr ¬ôDW¢D{„HsˆŽ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¡ôHr ¬ôDWDŒdHr¹£äDWD{HslÞŒDW¢D{„HsˆŽ„Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1039 10391270103912701039.DW!B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¡ôHr ¬ôDW¢D{„HsˆŽ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¡ôHr ¬ôDWDŒdHr¹£äDWD{HslÞŒDW¢D{„HsˆŽ„Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1039 10391270103912701039DWDWBœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¡ôHr ¬ôDW¢D{„HsˆŽ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¡ôHr ¬ôDWDŒdHr¹£äDWD{HslÞŒDW¢D{„HsˆŽ„Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391270103912701039.DW¾BÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW!YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¡ôHr ¬ôDW¢D{„HsˆŽ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¡ôHr ¬ôDWDŒdHr¹£äDWD{HslÞŒDW¢D{„HsˆŽ„Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391271103912711039DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW! AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÃðHr ÎðDW¢D¬Hsˆ¿Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÃðHr ÎðDWDºHr¹Ñ˜DWDœTHslÿÔDW¢D¬Hsˆ¿Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1039 10391271103912711039.DW!B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW! AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÃðHr ÎðDW¢D¬Hsˆ¿Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÃðHr ÎðDWDºHr¹Ñ˜DWDœTHslÿÔDW¢D¬Hsˆ¿Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1039 10391271103912711039DWDWBœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW! AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÃðHr ÎðDW¢D¬Hsˆ¿Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÃðHr ÎðDWDºHr¹Ñ˜DWDœTHslÿÔDW¢D¬Hsˆ¿Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1039 10391271103912711039.DW¾BÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW!YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÃðHr ÎðDW¢D¬Hsˆ¿Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÃðHr ÎðDWDºHr¹Ñ˜DWDœTHslÿÔDW¢D¬Hsˆ¿Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1039 10391272103912721039DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW½.DW! AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD¶Hr ÁDWD³ˆHr¹ËBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD¶Hr ÁDWD³ˆHr¹Ë......Phase 3A@..DW!DW½12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391272103912721039.DW!B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW½.DW! AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD¶Hr ÁDWD³ˆHr¹ËBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD¶Hr ÁDWD³ˆHr¹Ë......Phase 3A@..DW!DW½12-15 YearsAYYNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391273103912731039DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW! AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÄhHr ÏhDW¢D¬Hsˆ¿Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÄhHr ÏhDWD¹ÜHr¹Ñ\DWDœHslÿ˜DW¢D¬Hsˆ¿Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391273103912731039.DW!B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW! AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÄhHr ÏhDW¢D¬Hsˆ¿Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÄhHr ÏhDWD¹ÜHr¹Ñ\DWDœHslÿ˜DW¢D¬Hsˆ¿Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391273103912731039DWDWBœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW! AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÄhHr ÏhDW¢D¬Hsˆ¿Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÄhHr ÏhDWD¹ÜHr¹Ñ\DWDœHslÿ˜DW¢D¬Hsˆ¿Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA0C4591001C4591001 1039 10391273103912731039.DW¾BÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DW¾DW!YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÄhHr ÏhDW¢D¬Hsˆ¿Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWDW¢.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÄhHr ÏhDWD¹ÜHr¹Ñ\DWDœHslÿ˜DW¢D¬Hsˆ¿Phase 3A@..DW!.12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA@C4591001C4591001 1039 10391274103912741039DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW( AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD{„Hr©ÁDW£DqèHs‰ÖhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD{„Hr©ÁDWDpDHrÂÂDDWŽDštHsnOtDW£DqèHs‰ÖhPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391274103912741039.DW(B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW( AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD{„Hr©ÁDW£DqèHs‰ÖhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD{„Hr©ÁDWDpDHrÂÂDDWŽDštHsnOtDW£DqèHs‰ÖhPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391274103912741039DWŽDWŽB–REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW( AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD{„Hr©ÁDW£DqèHs‰ÖhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD{„Hr©ÁDWDpDHrÂÂDDWŽDštHsnOtDW£DqèHs‰ÖhPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391274103912741039.DWÃBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÃDW(YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD{„Hr©ÁDW£DqèHs‰ÖhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD{„Hr©ÁDWDpDHrÂÂDDWŽDštHsnOtDW£DqèHs‰ÖhPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391275103912751039DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDx´Hr©¾4DWD¸°HrÃ °BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDx´Hr©¾4DWD¸°HrÃ °......Phase 3A@..DW(DW»12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391275103912751039.DW(B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDx´Hr©¾4DWD¸°HrÃ °BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDx´Hr©¾4DWD¸°HrÃ °......Phase 3A@..DW(DW»12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391276103912761039DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¼.DW, AÐYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD”ÔHr©ÚTDW D‹°HrÄ/0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD”ÔHr©ÚTDW D‹°HrÄ/0......Phase 3A@..DW,DW¼12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1039 10391276103912761039.DW,B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¼.DW, AÐYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD”ÔHr©ÚTDW D‹°HrÄ/0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD”ÔHr©ÚTDW D‹°HrÄ/0......Phase 3A@..DW,DW¼12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1039 10391277103912771039DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÃDW, AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVùD˜Hr©ÝœDW£D ÈHsŠHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD˜Hr©ÝœDWD£\HrÅ˜\DWD¼Hslã<DW£D ÈHsŠHPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1039 10391277103912771039.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÃDW, AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVùD˜Hr©ÝœDW£D ÈHsŠHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD˜Hr©ÝœDWD£\HrÅ˜\DWD¼Hslã<DW£D ÈHsŠHPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1039 10391277103912771039DWDWB•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÃDW, AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVùD˜Hr©ÝœDW£D ÈHsŠHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD˜Hr©ÝœDWD£\HrÅ˜\DWD¼Hslã<DW£D ÈHsŠHPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1039 10391277103912771039.DWÃBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÃDW,YAàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVùD˜Hr©ÝœDW£D ÈHsŠHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD˜Hr©ÝœDWD£\HrÅ˜\DWD¼Hslã<DW£D ÈHsŠHPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1039 10391278103912781039DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DW¿.DW0 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¨HHr©íÈDW D‰ÐHrÄ-PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¨HHr©íÈDW D‰ÐHrÄ-P......Phase 3A@..DW0DW¿12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391278103912781039.DW0B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DW¿.DW0 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¨HHr©íÈDW D‰ÐHrÄ-PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW ....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¨HHr©íÈDW D‰ÐHrÄ-P......Phase 3A@..DW0DW¿12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391279103912791039DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD¯PHr©ôÐDW¦D–<Hsï<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD¯PHr©ôÐDWDÁÔHrÅ¶ÔDW‘DžpHsrGðDW¦D–<Hsï<Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391279103912791039.DW/B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD¯PHr©ôÐDW¦D–<Hsï<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD¯PHr©ôÐDWDÁÔHrÅ¶ÔDW‘DžpHsrGðDW¦D–<Hsï<Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391279103912791039DW‘DW‘B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD¯PHr©ôÐDW¦D–<Hsï<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD¯PHr©ôÐDWDÁÔHrÅ¶ÔDW‘DžpHsrGðDW¦D–<Hsï<Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1039 10391279103912791039.DWÃBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD¯PHr©ôÐDW¦D–<Hsï<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD¯PHr©ôÐDWDÁÔHrÅ¶ÔDW‘DžpHsrGðDW¦D–<Hsï<Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1039 10391280103912801039DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD„äHr«äDW£DÈdHsŠ,äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD„äHr«äDWD“lHrÆÙìDWŽD{ÀHsn0ÀDW£DÈdHsŠ,äPhase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391280103912801039.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD„äHr«äDW£DÈdHsŠ,äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD„äHr«äDWD“lHrÆÙìDWŽD{ÀHsn0ÀDW£DÈdHsŠ,äPhase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391280103912801039DWŽDWŽB•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD„äHr«äDW£DÈdHsŠ,äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD„äHr«äDWD“lHrÆÙìDWŽD{ÀHsn0ÀDW£DÈdHsŠ,äPhase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391280103912801039.DWÃBÊOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD„äHr«äDW£DÈdHsŠ,äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD„äHr«äDWD“lHrÆÙìDWŽD{ÀHsn0ÀDW£DÈdHsŠ,äPhase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391281103912811039DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÃxHr«ZxDW DËèHrÄohBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DW0BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÃxHr«ZxDW DËèHrÄoh......Phase 3A@..DW)DW¼12-15 YearsAYYNY. DW/DWýDWýAðYEARSDSAC4591001C4591001 1039 10391281103912811039.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÃxHr«ZxDW DËèHrÄohBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DW0BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÃxHr«ZxDW DËèHrÄoh......Phase 3A@..DW)DW¼12-15 YearsAYYNY. DW/DWýDWýAðYEARSDSA C4591001C4591001 1039 10391282103912821039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWË.DW, AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDzÐHr¬cPDWD¼¬HrÈT¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDzÐHr¬cPDWD¼¬HrÈT¬......Phase 3A@..DW,DWË12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391282103912821039.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWË.DW, AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDzÐHr¬cPDWD¼¬HrÈT¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDzÐHr¬cPDWD¼¬HrÈT¬......Phase 3A@..DW,DWË12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391283103912831039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW¾DW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD‚ŒHr¬kDW¢D¼4HsˆÏ4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD‚ŒHr¬kDWDl„HrÆ³DWDsHslÖ”DW¢D¼4HsˆÏ4Phase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1039 10391283103912831039.DW+B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW¾DW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD‚ŒHr¬kDW¢D¼4HsˆÏ4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD‚ŒHr¬kDWDl„HrÆ³DWDsHslÖ”DW¢D¼4HsˆÏ4Phase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1039 10391283103912831039DWDWB“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW¾DW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD‚ŒHr¬kDW¢D¼4HsˆÏ4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD‚ŒHr¬kDWDl„HrÆ³DWDsHslÖ”DW¢D¼4HsˆÏ4Phase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1039 10391283103912831039.DW¾BÄOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW¾DW+YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD‚ŒHr¬kDW¢D¼4HsˆÏ4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD‚ŒHr¬kDWDl„HrÆ³DWDsHslÖ”DW¢D¼4HsˆÏ4Phase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1039 10391284103912841039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÃ.DW+ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD„äHr¬mdDWDn(HrÆ´¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD„äHr¬mdDWDn(HrÆ´¨......Phase 3A@..DW+DWÃ12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1039 10391284103912841039.DW+B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÃ.DW+ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD„äHr¬mdDWDn(HrÆ´¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD„äHr¬mdDWDn(HrÆ´¨......Phase 3A@..DW+DWÃ12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1039 10391285103912851039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÉDW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDŒdHr¬täDW£Dt@Hs‰ØÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDŒdHr¬täDWD|tHrÈtDWŽDx´Hsn-´DW£Dt@Hs‰ØÀPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1039 10391285103912851039.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÉDW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDŒdHr¬täDW£Dt@Hs‰ØÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDŒdHr¬täDWD|tHrÈtDWŽDx´Hsn-´DW£Dt@Hs‰ØÀPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1039 10391285103912851039DWŽDWŽB”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÉDW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDŒdHr¬täDW£Dt@Hs‰ØÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDŒdHr¬täDWD|tHrÈtDWŽDx´Hsn-´DW£Dt@Hs‰ØÀPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391285103912851039.DWÉBÏOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÉDW,YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDŒdHr¬täDW£Dt@Hs‰ØÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDŒdHr¬täDWD|tHrÈtDWŽDx´Hsn-´DW£Dt@Hs‰ØÀPhase 3A@..DW,.12-15 YearsA YNN. DW‹DWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391286103912861039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÍ.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD4Hr¬w´DWD|8HrÈ8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD4Hr¬w´DWD|8HrÈ8......Phase 3A@..DW,DWÍ12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1039 10391286103912861039.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÍ.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD4Hr¬w´DWD|8HrÈ8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD4Hr¬w´DWD|8HrÈ8......Phase 3A@..DW,DWÍ12-15 YearsAYYNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1039 10391287103912871039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD™HHr¬ÈDW¢D†ˆHsˆ™ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD™HHr¬ÈDWD{HHrÈHDWDºHsm˜DW¢D†ˆHsˆ™ˆPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391287103912871039.DW/B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD™HHr¬ÈDW¢D†ˆHsˆ™ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD™HHr¬ÈDWD{HHrÈHDWDºHsm˜DW¢D†ˆHsˆ™ˆPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391287103912871039DWDWB“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD™HHr¬ÈDW¢D†ˆHsˆ™ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD™HHr¬ÈDWD{HHrÈHDWDºHsm˜DW¢D†ˆHsˆ™ˆPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1039 10391287103912871039.DWÃBÉOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÃDW/YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD™HHr¬ÈDW¢D†ˆHsˆ™ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD™HHr¬ÈDWD{HHrÈHDWDºHsm˜DW¢D†ˆHsˆ™ˆPhase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1039 10391289103912891039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÉ.DW, AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD¤ˆHr¬DWD²\HrÈJ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD¤ˆHr¬DWD²\HrÈJ\......Phase 3A@..DW,DWÉ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1039 10391289103912891039.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÉ.DW, AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD¤ˆHr¬DWD²\HrÈJ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD¤ˆHr¬DWD²\HrÈJ\......Phase 3A@..DW,DWÉ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1039 10391290103912901039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÊ.DW, AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD¶XHr¬žØDWDˆ¤HrÈ ¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD¶XHr¬žØDWDˆ¤HrÈ ¤......Phase 3A@..DW,DWÊ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391290103912901039.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÊ.DW, AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD¶XHr¬žØDWDˆ¤HrÈ ¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD¶XHr¬žØDWDˆ¤HrÈ ¤......Phase 3A@..DW,DWÊ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391291103912911039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWŽDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÅÐHr¬®PDWrDy,HsID,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW]DWr.DWUPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÅÐHr¬®PDWD—àHrÈ/àDW]D¨ÀHs-Ä@DWrDy,HsID,Phase 3A@..DW,.12-15 YearsA YNN. DWTDWýDWýAðYEARSDSAC4591001C4591001 1039 10391291103912911039.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWŽDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÅÐHr¬®PDWrDy,HsID,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW]DWr.DWUPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÅÐHr¬®PDWD—àHrÈ/àDW]D¨ÀHs-Ä@DWrDy,HsID,Phase 3A@..DW,.12-15 YearsA YNN. DWTDWýDWýAðYEARSDSA C4591001C4591001 1039 10391291103912911039DW]DW]BcREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWŽDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÅÐHr¬®PDWrDy,HsID,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW]DWr.DWUPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÅÐHr¬®PDWD—àHrÈ/àDW]D¨ÀHs-Ä@DWrDy,HsID,Phase 3A@..DW,.12-15 YearsA YNN. DWTDWýDWýAðYEARSDSA0C4591001C4591001 1039 10391291103912911039.DWŽB”OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWŽDW,YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÅÐHr¬®PDWrDy,HsID,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW]DWr.DWUPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÅÐHr¬®PDWD—àHrÈ/àDW]D¨ÀHs-Ä@DWrDy,HsID,Phase 3A@..DW,.12-15 YearsA YNN. DWTDWýDWýAðYEARSDSA@C4591001C4591001 1039 10391292103912921039DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÀ¨Hr¬©(DW£DvÔHs‰ÛTPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÀ¨Hr¬©(DWD¯PHrÈGPDWŽD{Hsn0DW£DvÔHs‰ÛTPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391292103912921039.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÀ¨Hr¬©(DW£DvÔHs‰ÛTPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÀ¨Hr¬©(DWD¯PHrÈGPDWŽD{Hsn0DW£DvÔHs‰ÛTPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391292103912921039DWŽDWŽB”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÀ¨Hr¬©(DW£DvÔHs‰ÛTPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÀ¨Hr¬©(DWD¯PHrÈGPDWŽD{Hsn0DW£DvÔHs‰ÛTPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391292103912921039.DWÃBÉOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW,YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÀ¨Hr¬©(DW£DvÔHs‰ÛTPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÀ¨Hr¬©(DWD¯PHrÈGPDWŽD{Hsn0DW£DvÔHs‰ÛTPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391293103912931039DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÌ.DW/ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD°|Hr°|DWD¯ŒHrÌ<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD°|Hr°|DWD¯ŒHrÌ<......Phase 3A@..DW/DWÌ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391293103912931039.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÌ.DW/ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD°|Hr°|DWD¯ŒHrÌ<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD°|Hr°|DWD¯ŒHrÌ<......Phase 3A@..DW/DWÌ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391294103912941039DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVþD²ÔHr°ÔDW£DHs‰ñ˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD²ÔHr°ÔDWDm°HrÎ0DWŽDv˜Hsn+˜DW£DHs‰ñ˜Phase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391294103912941039.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVþD²ÔHr°ÔDW£DHs‰ñ˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD²ÔHr°ÔDWDm°HrÎ0DWŽDv˜Hsn+˜DW£DHs‰ñ˜Phase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391294103912941039DWŽDWŽB‘REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVþD²ÔHr°ÔDW£DHs‰ñ˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD²ÔHr°ÔDWDm°HrÎ0DWŽDv˜Hsn+˜DW£DHs‰ñ˜Phase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391294103912941039.DWÄBÇOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1YAÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVþD²ÔHr°ÔDW£DHs‰ñ˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD²ÔHr°ÔDWDm°HrÎ0DWŽDv˜Hsn+˜DW£DHs‰ñ˜Phase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391295103912951039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÊ.DW> AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDxHrºáDWD§ÐHrÖÀPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDxHrºáDWD§ÐHrÖÀP......Phase 3A@..DW>DWÊ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSAC4591001C4591001 1039 10391295103912951039.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÊ.DW> AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDxHrºáDWD§ÐHrÖÀPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDxHrºáDWD§ÐHrÖÀP......Phase 3A@..DW>DWÊ12-15 YearsA YNY. DW‹DWýDWýAÐYEARSDSA C4591001C4591001 1039 10391296103912961039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW¿DW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‚PHrºëPDW£DŠÀHs‰ï@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‚PHrºëPDWDr$HrÖŠ¤DWŽDŒÜHsnAÜDW£DŠÀHs‰ï@Phase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391296103912961039.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW¿DW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‚PHrºëPDW£DŠÀHs‰ï@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‚PHrºëPDWDr$HrÖŠ¤DWŽDŒÜHsnAÜDW£DŠÀHs‰ï@Phase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391296103912961039DWŽDWŽB‰REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW¿DW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‚PHrºëPDW£DŠÀHs‰ï@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‚PHrºëPDWDr$HrÖŠ¤DWŽDŒÜHsnAÜDW£DŠÀHs‰ï@Phase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391296103912961039.DW¿BºOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DW¿DW>YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‚PHrºëPDW£DŠÀHs‰ï@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‚PHrºëPDWDr$HrÖŠ¤DWŽDŒÜHsnAÜDW£DŠÀHs‰ï@Phase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391297103912971039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÑ.DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‡xHrºðxDWDkHrÖƒœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‡xHrºðxDWDkHrÖƒœ......Phase 3A@...DWÑ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391297103912971039.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÑ.DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‡xHrºðxDWDkHrÖƒœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‡xHrºðxDWDkHrÖƒœ......Phase 3A@...DWÑ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391298103912981039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÊ.DW> AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŠHHrºóHDWDˆàHrÖ¡`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŠHHrºóHDWDˆàHrÖ¡`......Phase 3A@..DW>DWÊ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391298103912981039.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÊ.DW> AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŠHHrºóHDWDˆàHrÖ¡`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŠHHrºóHDWDˆàHrÖ¡`......Phase 3A@..DW>DWÊ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391299103912991039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¿DW= AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÌHrºöÌDW£DpHs‰óðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌHrºöÌDWDqpHrÖ‰ðDWŽD‹ìHsn@ìDW£DpHs‰óðPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1039 10391299103912991039.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¿DW= AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÌHrºöÌDW£DpHs‰óðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌHrºöÌDWDqpHrÖ‰ðDWŽD‹ìHsn@ìDW£DpHs‰óðPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1039 10391299103912991039DWŽDWŽB‰REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¿DW= AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÌHrºöÌDW£DpHs‰óðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌHrºöÌDWDqpHrÖ‰ðDWŽD‹ìHsn@ìDW£DpHs‰óðPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1039 10391299103912991039.DW¿BºOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¿DW=YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÌHrºöÌDW£DpHs‰óðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌHrºöÌDWDqpHrÖ‰ðDWŽD‹ìHsn@ìDW£DpHs‰óðPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1039 10391300103913001039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÓ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDª(Hr»(DWDsPHrÙ.ÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDª(Hr»(DWDsPHrÙ.Ð......Phase 3A@..DW=DWÓ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391300103913001039.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÓ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDª(Hr»(DWDsPHrÙ.ÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDª(Hr»(DWDsPHrÙ.Ð......Phase 3A@..DW=DWÓ12-15 YearsA YNY. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391301103913011039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÊDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©tHr»tDW£D½œHsŠ"Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©tHr»tDWDsŒHrÙ/DWD©tHsmôDW£D½œHsŠ"Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSAC4591001C4591001 1039 10391301103913011039.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÊDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©tHr»tDW£D½œHsŠ"Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©tHr»tDWDsŒHrÙ/DWD©tHsmôDW£D½œHsŠ"Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA C4591001C4591001 1039 10391301103913011039DWDWBˆREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÊDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©tHr»tDW£D½œHsŠ"Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©tHr»tDWDsŒHrÙ/DWD©tHsmôDW£D½œHsŠ"Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA0C4591001C4591001 1039 10391301103913011039.DWÊBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÊDW=YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©tHr»tDW£D½œHsŠ"Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DWŒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©tHr»tDWDsŒHrÙ/DWD©tHsmôDW£D½œHsŠ"Phase 3A@..DW=.12-15 YearsA YNN. DW‹DWýDWýAàYEARSDSA@C4591001C4591001 1039 10391302103913021039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD±0Hr»0DWD²\HrÕy\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD±0Hr»0DWD²\HrÕy\......Phase 3A@..DW=DW×12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391302103913021039.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD±0Hr»0DWD²\HrÕy\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD±0Hr»0DWD²\HrÕy\......Phase 3A@..DW=DW×12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391303103913031039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÃDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¿ôHr»(ôDW£Dr`Hs‰ÖàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¿ôHr»(ôDWDk”HrÙ'DWD±lHsmìDW£Dr`Hs‰ÖàPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391303103913031039.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÃDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¿ôHr»(ôDW£Dr`Hs‰ÖàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¿ôHr»(ôDWDk”HrÙ'DWD±lHsmìDW£Dr`Hs‰ÖàPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391303103913031039DWDWBˆREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÃDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¿ôHr»(ôDW£Dr`Hs‰ÖàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¿ôHr»(ôDWDk”HrÙ'DWD±lHsmìDW£Dr`Hs‰ÖàPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391303103913031039.DWÃB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÃDW>YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¿ôHr»(ôDW£Dr`Hs‰ÖàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¿ôHr»(ôDWDk”HrÙ'DWD±lHsmìDW£Dr`Hs‰ÖàPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391304103913041039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÊ.DW? AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÂÄHr»+ÄDWD¨HHrÖÀÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÂÄHr»+ÄDWD¨HHrÖÀÈ......Phase 3A@..DW?DWÊ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391304103913041039.DW?B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÊ.DW? AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÂÄHr»+ÄDWD¨HHrÖÀÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÂÄHr»+ÄDWD¨HHrÖÀÈ......Phase 3A@..DW?DWÊ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391305103913051039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW= AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½$HrÅ²$DW£D¹ÜHsŠ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½$HrÅ²$DW!DtHrÞu„DWŽDáHsn–DW£D¹ÜHsŠ\Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391305103913051039.DW=B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW= AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½$HrÅ²$DW£D¹ÜHsŠ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½$HrÅ²$DW!DtHrÞu„DWŽDáHsn–DW£D¹ÜHsŠ\Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391305103913051039DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW= AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½$HrÅ²$DW£D¹ÜHsŠ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½$HrÅ²$DW!DtHrÞu„DWŽDáHsn–DW£D¹ÜHsŠ\Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391305103913051039.DWÉB¼OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW=YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD½$HrÅ²$DW£D¹ÜHsŠ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD½$HrÅ²$DW!DtHrÞu„DWŽDáHsn–DW£D¹ÜHsŠ\Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391306103913061039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÙ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD½œHrÅ²œDW!DsÈHrÞuHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD½œHrÅ²œDW!DsÈHrÞuH......Phase 3A@..DW=DWÙ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391306103913061039.DW=B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÙ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD½œHrÅ²œDW!DsÈHrÞuHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD½œHrÅ²œDW!DsÈHrÞuH......Phase 3A@..DW=DWÙ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391307103913071039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¿DW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÆÀHrÅ»ÀDW£D–´Hs‰û4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÆÀHrÅ»ÀDW#D´´HráY4DWŽDÀ0Hsnu0DW£D–´Hs‰û4Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1039 10391307103913071039.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¿DW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÆÀHrÅ»ÀDW£D–´Hs‰û4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÆÀHrÅ»ÀDW#D´´HráY4DWŽDÀ0Hsnu0DW£D–´Hs‰û4Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1039 10391307103913071039DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¿DW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÆÀHrÅ»ÀDW£D–´Hs‰û4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÆÀHrÅ»ÀDW#D´´HráY4DWŽDÀ0Hsnu0DW£D–´Hs‰û4Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1039 10391307103913071039.DW¿B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW¿DW?YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÆÀHrÅ»ÀDW£D–´Hs‰û4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÆÀHrÅ»ÀDW#D´´HráY4DWŽDÀ0Hsnu0DW£D–´Hs‰û4Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1039 10391308103913081039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÓ.DW? AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÆüHrÅ»üDW#D´ðHráYpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÆüHrÅ»üDW#D´ðHráYp......Phase 3A@..DW?DWÓ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391308103913081039.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÓ.DW? AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÆüHrÅ»üDW#D´ðHráYpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÆüHrÅ»üDW#D´ðHráYp......Phase 3A@..DW?DWÓ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391309103913091039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDrØHrÆ¹XDW§D¸°Hsc0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDrØHrÆ¹XDW#DÇ8Hrák¸DW‘D„äHsr.dDW§D¸°Hsc0Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391309103913091039.DW?B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDrØHrÆ¹XDW§D¸°Hsc0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDrØHrÆ¹XDW#DÇ8Hrák¸DW‘D„äHsr.dDW§D¸°Hsc0Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391309103913091039DW‘DW‘BƒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW? AàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDrØHrÆ¹XDW§D¸°Hsc0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDrØHrÆ¹XDW#DÇ8Hrák¸DW‘D„äHsr.dDW§D¸°Hsc0Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1039 10391309103913091039.DWÑBÃOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÑDW?YAàYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDrØHrÆ¹XDW§D¸°Hsc0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDrØHrÆ¹XDW#DÇ8Hrák¸DW‘D„äHsr.dDW§D¸°Hsc0Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1039 10391310103913101039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÃDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD{HrÆÁŒDW¦D˜XHsñXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWŽDW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD{HrÆÁŒDW"D|8HrßÏ8DWŽDÄ¤Hsny¤DW¦D˜XHsñXPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391310103913101039.DW>B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÃDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD{HrÆÁŒDW¦D˜XHsñXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWŽDW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD{HrÆÁŒDW"D|8HrßÏ8DWŽDÄ¤Hsny¤DW¦D˜XHsñXPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391310103913101039DWŽDWŽB€REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÃDW> AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD{HrÆÁŒDW¦D˜XHsñXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWŽDW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD{HrÆÁŒDW"D|8HrßÏ8DWŽDÄ¤Hsny¤DW¦D˜XHsñXPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391310103913101039.DWÃBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÃDW>YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD{HrÆÁŒDW¦D˜XHsñXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWŽDW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD{HrÆÁŒDW"D|8HrßÏ8DWŽDÄ¤Hsny¤DW¦D˜XHsñXPhase 3A@..DW>.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391311103913111039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÒ.DWD AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‘ÈHrÆØHDW%D„äHrãÌdBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‘ÈHrÆØHDW%D„äHrãÌd......Phase 3A@..DWDDWÒ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1039 10391311103913111039.DWDB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÒ.DWD AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‘ÈHrÆØHDW%D„äHrãÌdBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‘ÈHrÆØHDW%D„äHrãÌd......Phase 3A@..DWDDWÒ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1039 10391312103913121039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWæ.DWD AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŽøHrÆÕxDW$D¼Hrâu¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŽøHrÆÕxDW$D¼Hrâu¼......Phase 3A@..DWDDWæ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391312103913121039.DWDB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWæ.DWD AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŽøHrÆÕxDW$D¼Hrâu¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŽøHrÆÕxDW$D¼Hrâu¼......Phase 3A@..DWDDWæ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391313103913131039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡|HrÆçüDW¢D”ÔHsˆ§ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡|HrÆçüDW$D”\HrâŠ\DWŽD² Hsng DW¢D”ÔHsˆ§ÔPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391313103913131039.DWEB7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡|HrÆçüDW¢D”ÔHsˆ§ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡|HrÆçüDW$D”\HrâŠ\DWŽD² Hsng DW¢D”ÔHsˆ§ÔPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391313103913131039DWŽDWŽB€REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡|HrÆçüDW¢D”ÔHsˆ§ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡|HrÆçüDW$D”\HrâŠ\DWŽD² Hsng DW¢D”ÔHsˆ§ÔPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1039 10391313103913131039.DWÃBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWEYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¡|HrÆçüDW¢D”ÔHsˆ§ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡|HrÆçüDW$D”\HrâŠ\DWŽD² Hsng DW¢D”ÔHsˆ§ÔPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1039 10391314103913141039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¨HrÆîŒDW¦DqèHsÊèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨HrÆîŒDW$D³LHrâ©LDW‘DpHsrˆDW¦DqèHsÊèPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391314103913141039.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¨HrÆîŒDW¦DqèHsÊèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨HrÆîŒDW$D³LHrâ©LDW‘DpHsrˆDW¦DqèHsÊèPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391314103913141039DW‘DW‘BƒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¨HrÆîŒDW¦DqèHsÊèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨HrÆîŒDW$D³LHrâ©LDW‘DpHsrˆDW¦DqèHsÊèPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1039 10391314103913141039.DWÃBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@YAàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¨HrÆîŒDW¦DqèHsÊèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨HrÆîŒDW$D³LHrâ©LDW‘DpHsrˆDW¦DqèHsÊèPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1039 10391315103913151039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÓ.DW? AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÃ´HrÇ 4DW#DÄhHráhèBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÃ´HrÇ 4DW#DÄhHráhè......Phase 3A@..DW?DWÓ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1039 10391315103913151039.DW?B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÓ.DW? AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÃ´HrÇ 4DW#DÄhHráhèBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÃ´HrÇ 4DW#DÄhHráhè......Phase 3A@..DW?DWÓ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1039 10391316103913161039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÓ.DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÄ,HrÇ ¬DW#DÄ,Hráh¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÄ,HrÇ ¬DW#DÄ,Hráh¬......Phase 3A@..DW?DWÓ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391316103913161039.DW?B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÓ.DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÄ,HrÇ ¬DW#DÄ,Hráh¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÄ,HrÇ ¬DW#DÄ,Hráh¬......Phase 3A@..DW?DWÓ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391317103913171039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¾DWA AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÄ¤HrÇ$DW¢DrœHsˆ…œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÄ¤HrÇ$DW$D¾PHrâ´PDWŽDÕüHsnŠüDW¢DrœHsˆ…œPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391317103913171039.DWAB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¾DWA AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÄ¤HrÇ$DW¢DrœHsˆ…œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÄ¤HrÇ$DW$D¾PHrâ´PDWŽDÕüHsnŠüDW¢DrœHsˆ…œPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391317103913171039DWŽDWŽB€REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¾DWA AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÄ¤HrÇ$DW¢DrœHsˆ…œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÄ¤HrÇ$DW$D¾PHrâ´PDWŽDÕüHsnŠüDW¢DrœHsˆ…œPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1039 10391317103913171039.DW¾B°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¾DWAYAÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDÄ¤HrÇ$DW¢DrœHsˆ…œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DWŽDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÄ¤HrÇ$DW$D¾PHrâ´PDWŽDÕüHsnŠüDW¢DrœHsˆ…œPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1039 10391318103913181039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWå.DWA AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÔ”HrÇDW%DÄhHräèBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW‹BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÔ”HrÇDW%DÄhHräè......Phase 3A@..DWADWå12-15 YearsA YNY. DWŠDWýDWýAðYEARSDSAC4591001C4591001 1039 10391318103913181039.DWAB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWå.DWA AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÔ”HrÇDW%DÄhHräèBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW‹BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÔ”HrÇDW%DÄhHräè......Phase 3A@..DWADWå12-15 YearsA YNY. DWŠDWýDWýAðYEARSDSA C4591001C4591001 1039 10391319103913191039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDu0HrÈ 0DWªDÆÀHs“eÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDu0HrÈ 0DW%DŸœHrãçDW”DÅHsvcDWªDÆÀHs“eÀPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391319103913191039.DWEB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDu0HrÈ 0DWªDÆÀHs“eÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDu0HrÈ 0DW%DŸœHrãçDW”DÅHsvcDWªDÆÀHs“eÀPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391319103913191039DW”DW”B…REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDu0HrÈ 0DWªDÆÀHs“eÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDu0HrÈ 0DW%DŸœHrãçDW”DÅHsvcDWªDÆÀHs“eÀPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1039 10391319103913191039.DWÆB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWEYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDu0HrÈ 0DWªDÆÀHs“eÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDu0HrÈ 0DW%DŸœHrãçDW”DÅHsvcDWªDÆÀHs“eÀPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1039 10391320103913201039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWó.DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‘HrÈ)DW%D’HrãÙ„Placebo Placebo 12-15 YearsA . . .DWDW%....DWŒPlacebo Placebo Placebo A .Placebo A .DWD‘HrÈ)DW%D’HrãÙ„......Phase 3A@..DWADWó12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSAC4591001C4591001 1039 10391320103913201039.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWó.DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‘HrÈ)DW%D’HrãÙ„Placebo Placebo 12-15 YearsA . . .DWDW%....DWŒPlacebo Placebo Placebo A .Placebo A .DWD‘HrÈ)DW%D’HrãÙ„......Phase 3A@..DWADWó12-15 YearsA YNN. DW‹DWýDWýAÀYEARSDSA C4591001C4591001 1039 10391321103913211039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÊDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŒ HrÈ$ DW§DÂˆHsmPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŒ HrÈ$ DW%Dm8Hrã´¸DW‘Dp€HsrDW§DÂˆHsmPhase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391321103913211039.DWDB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÊDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŒ HrÈ$ DW§DÂˆHsmPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŒ HrÈ$ DW%Dm8Hrã´¸DW‘Dp€HsrDW§DÂˆHsmPhase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391321103913211039DW‘DW‘B‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÊDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŒ HrÈ$ DW§DÂˆHsmPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŒ HrÈ$ DW%Dm8Hrã´¸DW‘Dp€HsrDW§DÂˆHsmPhase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1039 10391321103913211039.DWÊB»OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÊDWDYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŒ HrÈ$ DW§DÂˆHsmPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŒ HrÈ$ DW%Dm8Hrã´¸DW‘Dp€HsrDW§DÂˆHsmPhase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1039 10391322103913221039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¶”HrÈN”DW%D¡ôHrãétBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¶”HrÈN”DW%D¡ôHrãét......Phase 3A@..DWADWÔ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1039 10391322103913221039.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¶”HrÈN”DW%D¡ôHrãétBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¶”HrÈN”DW%D¡ôHrãét......Phase 3A@..DWADWÔ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1039 10391323103913231039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDºÌHrÈRÌDW%D»€HräBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDºÌHrÈRÌDW%D»€Hrä......Phase 3A@..DWADWÔ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391323103913231039.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDºÌHrÈRÌDW%D»€HräBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDºÌHrÈRÌDW%D»€Hrä......Phase 3A@..DWADWÔ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391324103913241039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÜÈHrÈtÈDW%D½`HräàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÜÈHrÈtÈDW%D½`Hräà......Phase 3A@..DWADWÔ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391324103913241039.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÜÈHrÈtÈDW%D½`HräàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÜÈHrÈtÈDW%D½`Hräà......Phase 3A@..DWADWÔ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391325103913251039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÃDWG AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD´´HrÌA4DW¢DxxHsˆ‹xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´´HrÌA4DW(Dv\Hrç²\DWDHslñDW¢DxxHsˆ‹xPhase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391325103913251039.DWGB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÃDWG AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD´´HrÌA4DW¢DxxHsˆ‹xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´´HrÌA4DW(Dv\Hrç²\DWDHslñDW¢DxxHsˆ‹xPhase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391325103913251039DWDWB{REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÃDWG AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD´´HrÌA4DW¢DxxHsˆ‹xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´´HrÌA4DW(Dv\Hrç²\DWDHslñDW¢DxxHsˆ‹xPhase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391325103913251039.DWÃB±OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÃDWGYAÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD´´HrÌA4DW¢DxxHsˆ‹xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´´HrÌA4DW(Dv\Hrç²\DWDHslñDW¢DxxHsˆ‹xPhase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391326103913261039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWGDWå.DWG AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD´xHrÌ@øDW(DwÄHrç³ÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWjBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD´xHrÌ@øDW(DwÄHrç³Ä......Phase 3A@..DWGDWå12-15 YearsA YNY. DWiDWýDWýAðYEARSDSAC4591001C4591001 1039 10391326103913261039.DWGB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWGDWå.DWG AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD´xHrÌ@øDW(DwÄHrç³ÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWjBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD´xHrÌ@øDW(DwÄHrç³Ä......Phase 3A@..DWGDWå12-15 YearsA YNY. DWiDWýDWýAðYEARSDSA C4591001C4591001 1039 10391327103913271039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWÙ.DWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¸°HrÌE0DW(DzÐHrç¶ÐPlacebo Placebo 12-15 YearsA . . .DWDW(....DWPlacebo Placebo Placebo A .Placebo A .DWD¸°HrÌE0DW(DzÐHrç¶Ð......Phase 3A@..DWEDWÙ12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1039 10391327103913271039.DWEB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWÙ.DWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¸°HrÌE0DW(DzÐHrç¶ÐPlacebo Placebo 12-15 YearsA . . .DWDW(....DWPlacebo Placebo Placebo A .Placebo A .DWD¸°HrÌE0DW(DzÐHrç¶Ð......Phase 3A@..DWEDWÙ12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1039 10391328103913281039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÅDWE AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDºTHrÌFÔDW£D·üHsŠ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDºTHrÌFÔDW)DkÐHrèùPDWŽD¯PHsndPDW£D·üHsŠ|Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391328103913281039.DWEB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÅDWE AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDºTHrÌFÔDW£D·üHsŠ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDºTHrÌFÔDW)DkÐHrèùPDWŽD¯PHsndPDW£D·üHsŠ|Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391328103913281039DWŽDWŽB|REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÅDWE AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDºTHrÌFÔDW£D·üHsŠ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDºTHrÌFÔDW)DkÐHrèùPDWŽD¯PHsndPDW£D·üHsŠ|Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1039 10391328103913281039.DWÅB³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÅDWEYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDºTHrÌFÔDW£D·üHsŠ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDºTHrÌFÔDW)DkÐHrèùPDWŽD¯PHsndPDW£D·üHsŠ|Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1039 10391329103913291039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔXHrÌ`ØDW©D½œHs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔXHrÌ`ØDW(Dy¤Hrçµ¤DW”DÅXHsvcXDW©D½œHs’Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391329103913291039.DWEB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔXHrÌ`ØDW©D½œHs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔXHrÌ`ØDW(Dy¤Hrçµ¤DW”DÅXHsvcXDW©D½œHs’Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391329103913291039DW”DW”B‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔXHrÌ`ØDW©D½œHs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔXHrÌ`ØDW(Dy¤Hrçµ¤DW”DÅXHsvcXDW©D½œHs’Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1039 10391329103913291039.DWÆB´OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWEYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÔXHrÌ`ØDW©D½œHs’Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW”DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÔXHrÌ`ØDW(Dy¤Hrçµ¤DW”DÅXHsvcXDW©D½œHs’Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1039 10391330103913301039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWæ.DWH AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒ´HrÌ_4DW)D¾ÈHréLHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWqBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒ´HrÌ_4DW)D¾ÈHréLH......Phase 3A@..DWHDWæ12-15 YearsA YNY. DWpDWýDWýAðYEARSDSAC4591001C4591001 1039 10391330103913301039.DWHB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWæ.DWH AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒ´HrÌ_4DW)D¾ÈHréLHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWqBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒ´HrÌ_4DW)D¾ÈHréLH......Phase 3A@..DWHDWæ12-15 YearsA YNY. DWpDWýDWýAðYEARSDSA C4591001C4591001 1039 10391331103913311039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDW×.DWE AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDr`HrÍP`DW(Dx<Hrç´<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDr`HrÍP`DW(Dx<Hrç´<......Phase 3A@..DWEDW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1039 10391331103913311039.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDW×.DWE AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDr`HrÍP`DW(Dx<Hrç´<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDr`HrÍP`DW(Dx<Hrç´<......Phase 3A@..DWEDW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1039 10391332103913321039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWL..DWL AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD|°HrÍZ°DW)Dp€HrèþBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWrBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD|°HrÍZ°DW)Dp€Hrèþ......Phase 3A@DW©.DWL.12-15 YearsA YNN. DWqDW©DW©AÐYEARSDSAC4591001C4591001 1039 10391332103913321039.DWLB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWL..DWL AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD|°HrÍZ°DW)Dp€HrèþBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWrBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD|°HrÍZ°DW)Dp€Hrèþ......Phase 3A@DW©.DWL.12-15 YearsA YNN. DWqDW©DW©AÐYEARSDSA C4591001C4591001 1039 10391332103913321039.DW©B–FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject has withdrawn consent. DWL..DWLYAÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD|°HrÍZ°DW)Dp€HrèþBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWrBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD|°HrÍZ°DW)Dp€Hrèþ......Phase 3A@DW©.DWL.12-15 YearsA YNN. DWqDW©DW©AÐYEARSDSApC4591001C4591001 1039 10391333103913331039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡HrÍeDWªDÇtHs“ftPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡HrÍeDW)Du0Hré°DW•DÆHHswµÈDWªDÇtHs“ftPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1039 10391333103913331039.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡HrÍeDWªDÇtHs“ftPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡HrÍeDW)Du0Hré°DW•DÆHHswµÈDWªDÇtHs“ftPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1039 10391333103913331039DW•DW•B‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡HrÍeDWªDÇtHs“ftPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡HrÍeDW)Du0Hré°DW•DÆHHswµÈDWªDÇtHs“ftPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1039 10391333103913331039.DWÆB³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWEYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡HrÍeDWªDÇtHs“ftPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡HrÍeDW)Du0Hré°DW•DÆHHswµÈDWªDÇtHs“ftPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1039 10391334103913341039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHrÍeðDWªDÇ8Hs“f8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡ðHrÍeðDW)DtôHrétDW•DÆ„Hsw¶DWªDÇ8Hs“f8Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391334103913341039.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHrÍeðDWªDÇ8Hs“f8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡ðHrÍeðDW)DtôHrétDW•DÆ„Hsw¶DWªDÇ8Hs“f8Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391334103913341039DW•DW•B‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHrÍeðDWªDÇ8Hs“f8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡ðHrÍeðDW)DtôHrétDW•DÆ„Hsw¶DWªDÇ8Hs“f8Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1039 10391334103913341039.DWÆB³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÆDWEYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD‡ðHrÍeðDWªDÇ8Hs“f8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD‡ðHrÍeðDW)DtôHrétDW•DÆ„Hsw¶DWªDÇ8Hs“f8Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1039 10391335103913351039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWGDWæ.DWG AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD£ HrÍ DW)D|°Hré 0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWGBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD£ HrÍ DW)D|°Hré 0......Phase 3A@..DWGDWæ12-15 YearsA YNY. DWFDWýDWýAðYEARSDSAC4591001C4591001 1039 10391335103913351039.DWGB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWGDWæ.DWG AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD£ HrÍ DW)D|°Hré 0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWGBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD£ HrÍ DW)D|°Hré 0......Phase 3A@..DWGDWæ12-15 YearsA YNY. DWFDWýDWýAðYEARSDSA C4591001C4591001 1039 10391336103913361039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWGDWæ.DWG AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¢¨HrÍ€¨DW)D|tHré ôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¢¨HrÍ€¨DW)D|tHré ô......Phase 3A@..DWGDWæ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1039 10391336103913361039.DWGB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWGDWæ.DWG AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¢¨HrÍ€¨DW)D|tHré ôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¢¨HrÍ€¨DW)D|tHré ô......Phase 3A@..DWGDWæ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1039 10391337103913371039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWL.DW¿DWL AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDªÜHrÍˆÜDW£DŸœHsŠPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDªÜHrÍˆÜDW*DndHrêMdDWŽD ÈHsnUÈDW£DŸœHsŠPhase 3A@..DWL.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1039 10391337103913371039.DWLB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWL.DW¿DWL AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDªÜHrÍˆÜDW£DŸœHsŠPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDªÜHrÍˆÜDW*DndHrêMdDWŽD ÈHsnUÈDW£DŸœHsŠPhase 3A@..DWL.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1039 10391337103913371039DWŽDWŽB{REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWL.DW¿DWL AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDªÜHrÍˆÜDW£DŸœHsŠPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDªÜHrÍˆÜDW*DndHrêMdDWŽD ÈHsnUÈDW£DŸœHsŠPhase 3A@..DWL.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1039 10391337103913371039.DW¿B¬OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWL.DW¿DWLYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDªÜHrÍˆÜDW£DŸœHsŠPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDªÜHrÍˆÜDW*DndHrêMdDWŽD ÈHsnUÈDW£DŸœHsŠPhase 3A@..DWL.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1039 10391338103913381039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWGDWß.DWG AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÐ˜HrÍ®˜DW*DwˆHrêVˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÐ˜HrÍ®˜DW*DwˆHrêVˆ......Phase 3A@..DWGDWß12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1039 10391338103913381039.DWGB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWGDWß.DWG AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÐ˜HrÍ®˜DW*DwˆHrêVˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÐ˜HrÍ®˜DW*DwˆHrêVˆ......Phase 3A@..DWGDWß12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1039 10391339103913391039DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÅDWG AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑHrÍ¯DW¦DrœHsËœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑHrÍ¯DW*DxHrêWDW’D~HssyDW¦DrœHsËœPhase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1039 10391339103913391039.DWGB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÅDWG AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑHrÍ¯DW¦DrœHsËœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑHrÍ¯DW*DxHrêWDW’D~HssyDW¦DrœHsËœPhase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1039 10391339103913391039DW’DW’BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÅDWG AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑHrÍ¯DW¦DrœHsËœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑHrÍ¯DW*DxHrêWDW’D~HssyDW¦DrœHsËœPhase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1039 10391339103913391039.DWÅB²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÅDWGYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÑHrÍ¯DW¦DrœHsËœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÑHrÍ¯DW*DxHrêWDW’D~HssyDW¦DrœHsËœPhase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1044 10441251104412511044DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¶.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDÒ´Hr•4DVÿD§Hr±ÕœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDÒ´Hr•4DVÿD§Hr±Õœ......Phase 3A@..DWDW¶12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441251104412511044.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¶.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDÒ´Hr•4DVÿD§Hr±ÕœBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDÒ´Hr•4DVÿD§Hr±Õœ......Phase 3A@..DWDW¶12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441252104412521044DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDäHHr•ÈDW¦D€Hsö€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDäHHr•ÈDVþD4Hr°Š4DW‘D—hHsr@èDW¦D€Hsö€Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441252104412521044.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDäHHr•ÈDW¦D€Hsö€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDäHHr•ÈDVþD4Hr°Š4DW‘D—hHsr@èDW¦D€Hsö€Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441252104412521044DW‘DW‘B©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDäHHr•ÈDW¦D€Hsö€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDäHHr•ÈDVþD4Hr°Š4DW‘D—hHsr@èDW¦D€Hsö€Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441252104412521044.DWÃBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDWYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVéDäHHr•ÈDW¦D€Hsö€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVéDVþ.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVéDäHHr•ÈDVþD4Hr°Š4DW‘D—hHsr@èDW¦D€Hsö€Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441253104412531044DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDøèHr•&hDVþD§XHr°„XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDøèHr•&hDVþD§XHr°„X......Phase 3A@..DWDW®12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441253104412531044.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDøèHr•&hDVþD§XHr°„XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDøèHr•&hDVþD§XHr°„X......Phase 3A@..DWDW®12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441255104412551044DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¸.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêD¢¨Hr–!¨DVþDÃ´Hr° ´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVþ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêD¢¨Hr–!¨DVþDÃ´Hr° ´......Phase 3A@..DWDW¸12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441255104412551044.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¸.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêD¢¨Hr–!¨DVþDÃ´Hr° ´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVþ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêD¢¨Hr–!¨DVþDÃ´Hr° ´......Phase 3A@..DWDW¸12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441256104412561044DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD¢äHr–!äDW¨D—,Hs“,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DW‘DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD¢äHr–!äDVþDÃðHr° ðDW‘D¼4Hsre´DW¨D—,Hs“,Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1044 10441256104412561044.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD¢äHr–!äDW¨D—,Hs“,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DW‘DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD¢äHr–!äDVþDÃðHr° ðDW‘D¼4Hsre´DW¨D—,Hs“,Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1044 10441256104412561044DW‘DW‘B¨REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD¢äHr–!äDW¨D—,Hs“,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DW‘DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD¢äHr–!äDVþDÃðHr° ðDW‘D¼4Hsre´DW¨D—,Hs“,Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441256104412561044.DWÄBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDWYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD¢äHr–!äDW¨D—,Hs“,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVþ.DW‘DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD¢äHr–!äDVþDÃðHr° ðDW‘D¼4Hsre´DW¨D—,Hs“,Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441257104412571044DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW½.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDØTHr–WTDWDá´Hr³a´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDØTHr–WTDWDá´Hr³a´......Phase 3A@..DWDW½12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441257104412571044.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW½.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDØTHr–WTDWDá´Hr³a´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDØTHr–WTDWDá´Hr³a´......Phase 3A@..DWDW½12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441259104412591044DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDì|Hr–k|DVÿD¥<Hr±Ó¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDì|Hr–k|DVÿD¥<Hr±Ó¼......Phase 3A@..DWDW°12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441259104412591044.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDì|Hr–k|DVÿD¥<Hr±Ó¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVÿ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDì|Hr–k|DVÿD¥<Hr±Ó¼......Phase 3A@..DWDW°12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441260104412601044DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¾DW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDù$Hr–x$DW¢Dá´Hsˆô´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWŽDW¢.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDù$Hr–x$DVÿDÎHr±ü„DWŽDÞäHsn“äDW¢Dá´Hsˆô´Phase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1044 10441260104412601044.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¾DW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDù$Hr–x$DW¢Dá´Hsˆô´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWŽDW¢.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDù$Hr–x$DVÿDÎHr±ü„DWŽDÞäHsn“äDW¢Dá´Hsˆô´Phase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1044 10441260104412601044DWŽDWŽB¥REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¾DW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDù$Hr–x$DW¢Dá´Hsˆô´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWŽDW¢.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDù$Hr–x$DVÿDÎHr±ü„DWŽDÞäHsn“äDW¢Dá´Hsˆô´Phase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441260104412601044.DW¾BÕOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¾DWYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDù$Hr–x$DW¢Dá´Hsˆô´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWŽDW¢.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDù$Hr–x$DVÿDÎHr±ü„DWŽDÞäHsn“äDW¢Dá´Hsˆô´Phase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441261104412611044DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¿DW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDùØHr–xØDW£DäüHsŠI|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDùØHr–xØDVÿDäÀHr²@DWŽDÂHsnwDW£DäüHsŠI|Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1044 10441261104412611044.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¿DW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDùØHr–xØDW£DäüHsŠI|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDùØHr–xØDVÿDäÀHr²@DWŽDÂHsnwDW£DäüHsŠI|Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1044 10441261104412611044DWŽDWŽB¥REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¿DW AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDùØHr–xØDW£DäüHsŠI|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDùØHr–xØDVÿDäÀHr²@DWŽDÂHsnwDW£DäüHsŠI|Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441261104412611044.DW¿BÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¿DWYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDùØHr–xØDW£DäüHsŠI|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDùØHr–xØDVÿDäÀHr²@DWŽDÂHsnwDW£DäüHsŠI|Phase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441263104412631044DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DWµ.DW! AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÓàHrž;àDWDÆHHr¹ÝÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÓàHrž;àDWDÆHHr¹ÝÈ......Phase 3A@..DW!DWµ12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441263104412631044.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DWµ.DW! AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDÓàHrž;àDWDÆHHr¹ÝÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDÓàHrž;àDWDÆHHr¹ÝÈ......Phase 3A@..DW!DWµ12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441264104412641044DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDíäHržUäDWóD•ÄHsórDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW×DWó.DWÅPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDíäHržUäDWDŸ$Hr¹¶¤DW×D×dHsÎÉäDWóD•ÄHsórDPhase 3A@..DW(DW»12-15 YearsA YNN. DWÄDWýDWýAàYEARSDSAC4591001C4591001 1044 10441264104412641044.DW(B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDíäHržUäDWóD•ÄHsórDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW×DWó.DWÅPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDíäHržUäDWDŸ$Hr¹¶¤DW×D×dHsÎÉäDWóD•ÄHsórDPhase 3A@..DW(DW»12-15 YearsA YNN. DWÄDWýDWýAàYEARSDSA C4591001C4591001 1044 10441264104412641044DW×DW×BèREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDíäHržUäDWóD•ÄHsórDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW×DWó.DWÅPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDíäHržUäDWDŸ$Hr¹¶¤DW×D×dHsÎÉäDWóD•ÄHsórDPhase 3A@..DW(DW»12-15 YearsA YNN. DWÄDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441265104412651044DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDöHrž^DW¨DÇ°HsÃ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDöHrž^DWDžpHr¹µðDW“DÃxHsuøDW¨DÇ°HsÃ°Phase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441265104412651044.DW"B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDöHrž^DW¨DÇ°HsÃ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDöHrž^DWDžpHr¹µðDW“DÃxHsuøDW¨DÇ°HsÃ°Phase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441265104412651044DW“DW“B¤REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDöHrž^DW¨DÇ°HsÃ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDöHrž^DWDžpHr¹µðDW“DÃxHsuøDW¨DÇ°HsÃ°Phase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441265104412651044.DWÅBÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW"YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDöHrž^DW¨DÇ°HsÃ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDöHrž^DWDžpHr¹µðDW“DÃxHsuøDW¨DÇ°HsÃ°Phase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441266104412661044DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW».DW% AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD¢¨HrŸ\(DWD»DHr¹ÒÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD¢¨HrŸ\(DWD»DHr¹ÒÄ......Phase 3A@..DW%DW»12-15 YearsA YNY. DWý.DWýAàYEARSDSAC4591001C4591001 1044 10441266104412661044.DW%B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW».DW% AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD¢¨HrŸ\(DWD»DHr¹ÒÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD¢¨HrŸ\(DWD»DHr¹ÒÄ......Phase 3A@..DW%DW»12-15 YearsA YNY. DWý.DWýAàYEARSDSA C4591001C4591001 1044 10441267104412671044DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÉDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD©°HrŸc0DW¨DèHs©èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD©°HrŸc0DWDØHr¹¨XDW“D ÈHstíHDW¨DèHs©èPhase 3A@..DW!.12-15 YearsA YNN. DWŽDWýDWýAàYEARSDSAC4591001C4591001 1044 10441267104412671044.DW!B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÉDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD©°HrŸc0DW¨DèHs©èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD©°HrŸc0DWDØHr¹¨XDW“D ÈHstíHDW¨DèHs©èPhase 3A@..DW!.12-15 YearsA YNN. DWŽDWýDWýAàYEARSDSA C4591001C4591001 1044 10441267104412671044DW“DW“B£REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÉDW! AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD©°HrŸc0DW¨DèHs©èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD©°HrŸc0DWDØHr¹¨XDW“D ÈHstíHDW¨DèHs©èPhase 3A@..DW!.12-15 YearsA YNN. DWŽDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441267104412671044.DWÉBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÉDW!YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñD©°HrŸc0DW¨DèHs©èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñD©°HrŸc0DWDØHr¹¨XDW“D ÈHstíHDW¨DèHs©èPhase 3A@..DW!.12-15 YearsA YNN. DWŽDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441268104412681044DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¿.DW! AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD´ðHrŸnpDWDÞ¨Hr¹ö(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD´ðHrŸnpDWDÞ¨Hr¹ö(......Phase 3A@..DW!DW¿12-15 YearsAYYNY. DWý.DWýAðYEARSDSAC4591001C4591001 1044 10441268104412681044.DW!B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¿.DW! AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD´ðHrŸnpDWDÞ¨Hr¹ö(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD´ðHrŸnpDWDÞ¨Hr¹ö(......Phase 3A@..DW!DW¿12-15 YearsAYYNY. DWý.DWýAðYEARSDSA C4591001C4591001 1044 10441270104412701044DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¾.DW$ AÐYEARSFA NOT REPORTED ApNOT REPORTED ApYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÙHrŸ’ˆDWD ŒHr½¬ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÙHrŸ’ˆDWD ŒHr½¬Œ......Phase 3A@..DW$DW¾12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441270104412701044.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¾.DW$ AÐYEARSFA NOT REPORTED ApNOT REPORTED ApYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDÙHrŸ’ˆDWD ŒHr½¬ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDÙHrŸ’ˆDWD ŒHr½¬Œ......Phase 3A@..DW$DW¾12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441271104412711044DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¹.DW% AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÿxHrŸ¸øDWDØÌHr¹ðLPlacebo Placebo 12-15 YearsA . . .DVñDW....DWPlacebo Placebo Placebo A .Placebo A .DVñDÿxHrŸ¸øDWDØÌHr¹ðL......Phase 3A@..DW%DW¹12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441271104412711044.DW%B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¹.DW% AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDÿxHrŸ¸øDWDØÌHr¹ðLPlacebo Placebo 12-15 YearsA . . .DVñDW....DWPlacebo Placebo Placebo A .Placebo A .DVñDÿxHrŸ¸øDWDØÌHr¹ðL......Phase 3A@..DW%DW¹12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441273104412731044DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¿.DW$ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñEë@HrŸÈ4DWDÍHr¹ä”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñEë@HrŸÈ4DWDÍHr¹ä”......Phase 3A@..DW$DW¿12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441273104412731044.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¿.DW$ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñEë@HrŸÈ4DWDÍHr¹ä”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñEë@HrŸÈ4DWDÍHr¹ä”......Phase 3A@..DW$DW¿12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441274104412741044DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWkDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñEç€HrŸÇøDWODÎHst„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW8DWO.DW0Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñEç€HrŸÇøDWDÅÐHr¹ÝPDW8DDHrüñDDWODÎHst„Phase 3A@..DW$.12-15 YearsA YNN. DW/DWýDWýAðYEARSDSAC4591001C4591001 1044 10441274104412741044.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWkDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñEç€HrŸÇøDWODÎHst„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW8DWO.DW0Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñEç€HrŸÇøDWDÅÐHr¹ÝPDW8DDHrüñDDWODÎHst„Phase 3A@..DW$.12-15 YearsA YNN. DW/DWýDWýAðYEARSDSA C4591001C4591001 1044 10441274104412741044DW8DW8BHREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWkDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñEç€HrŸÇøDWODÎHst„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW8DWO.DW0Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñEç€HrŸÇøDWDÅÐHr¹ÝPDW8DDHrüñDDWODÎHst„Phase 3A@..DW$.12-15 YearsA YNN. DW/DWýDWýAðYEARSDSA0C4591001C4591001 1044 10441274104412741044.DWkB{OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWkDW$YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñEç€HrŸÇøDWODÎHst„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW8DWO.DW0Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñEç€HrŸÇøDWDÅÐHr¹ÝPDW8DDHrüñDDWODÎHst„Phase 3A@..DW$.12-15 YearsA YNN. DW/DWýDWýAðYEARSDSA@C4591001C4591001 1044 10441275104412751044DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÄDW% AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD–´Hr ¡´DW¨DpHs‹pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD–´Hr ¡´DWDžpHr»pDW‘D·HHsr`ÈDW¨DpHs‹pPhase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441275104412751044.DW%B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÄDW% AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD–´Hr ¡´DW¨DpHs‹pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD–´Hr ¡´DWDžpHr»pDW‘D·HHsr`ÈDW¨DpHs‹pPhase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441275104412751044DW‘DW‘B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÄDW% AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD–´Hr ¡´DW¨DpHs‹pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD–´Hr ¡´DWDžpHr»pDW‘D·HHsr`ÈDW¨DpHs‹pPhase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1044 10441275104412751044.DWÄBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÄDW%YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD–´Hr ¡´DW¨DpHs‹pPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD–´Hr ¡´DWDžpHr»pDW‘D·HHsr`ÈDW¨DpHs‹pPhase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1044 10441276104412761044DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW».DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDªdHr µdDWDŸ`Hr»`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDªdHr µdDWDŸ`Hr»`......Phase 3A@..DW!DW»12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1044 10441276104412761044.DW!B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW».DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDªdHr µdDWDŸ`Hr»`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDªdHr µdDWDŸ`Hr»`......Phase 3A@..DW!DW»12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1044 10441277104412771044DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÆüHr ÑüDW§D…˜Hs0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÆüHr ÑüDWD•ˆHrºþˆDW‘Dì|Hsr•üDW§D…˜Hs0Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1044 10441277104412771044.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÆüHr ÑüDW§D…˜Hs0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÆüHr ÑüDWD•ˆHrºþˆDW‘Dì|Hsr•üDW§D…˜Hs0Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1044 10441277104412771044DW‘DW‘B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÆüHr ÑüDW§D…˜Hs0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÆüHr ÑüDWD•ˆHrºþˆDW‘Dì|Hsr•üDW§D…˜Hs0Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441277104412771044.DWÃBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW#YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÆüHr ÑüDW§D…˜Hs0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÆüHr ÑüDWD•ˆHrºþˆDW‘Dì|Hsr•üDW§D…˜Hs0Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441278104412781044DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW½.DW# AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÆHHr ÑHDWDß Hr»H BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÆHHr ÑHDWDß Hr»H ......Phase 3A@..DW#DW½12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441278104412781044.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW½.DW# AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÆHHr ÑHDWDß Hr»H BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÆHHr ÑHDWDß Hr»H ......Phase 3A@..DW#DW½12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441279104412791044DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DWÃ.DW$ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDüäHr¡äDWD”˜Hrºý˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW1BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDüäHr¡äDWD”˜Hrºý˜......Phase 3A@..DW$DWÃ12-15 YearsA YNY. DW0DWýDWýAðYEARSDSAC4591001C4591001 1044 10441279104412791044.DW$B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DWÃ.DW$ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDüäHr¡äDWD”˜Hrºý˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW1BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDüäHr¡äDWD”˜Hrºý˜......Phase 3A@..DW$DWÃ12-15 YearsA YNY. DW0DWýDWýAðYEARSDSA C4591001C4591001 1044 10441280104412801044DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWTDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDü¨Hr¡¨DW8DÍHrý!Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW$DW8.DW"Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDü¨Hr¡¨DWD“äHrºüäDW$D4Hrâ…4DW8DÍHrý!Phase 3A@..DW$.12-15 YearsA YNN. DW!DWýDWýAðYEARSDSAC4591001C4591001 1044 10441280104412801044DW$DW$B3REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWTDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDü¨Hr¡¨DW8DÍHrý!Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW$DW8.DW"Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDü¨Hr¡¨DWD“äHrºüäDW$D4Hrâ…4DW8DÍHrý!Phase 3A@..DW$.12-15 YearsA YNN. DW!DWýDWýAðYEARSDSA C4591001C4591001 1044 10441280104412801044.DW$B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWTDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDü¨Hr¡¨DW8DÍHrý!Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW$DW8.DW"Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDü¨Hr¡¨DWD“äHrºüäDW$D4Hrâ…4DW8DÍHrý!Phase 3A@..DW$.12-15 YearsA YNN. DW!DWýDWýAðYEARSDSA0C4591001C4591001 1044 10441280104412801044.DWTBcOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWTDW$YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDü¨Hr¡¨DW8DÍHrý!Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW$DW8.DW"Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDü¨Hr¡¨DWD“äHrºüäDW$D4Hrâ…4DW8DÍHrý!Phase 3A@..DW$.12-15 YearsA YNN. DW!DWýDWýAðYEARSDSA@C4591001C4591001 1044 10441281104412811044DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¾.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòE`€Hr¡DWDpHr»pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòE`€Hr¡DWDpHr»p......Phase 3A@..DW#DW¾12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441281104412811044.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¾.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòE`€Hr¡DWDpHr»pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòE`€Hr¡DWDpHr»p......Phase 3A@..DW#DW¾12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441282104412821044DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWwDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòEF@Hr¡dDW[DÀäHs+9dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWFDW[.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòEF@Hr¡dDWDÏ¨Hr¼Š(DWFD¼Hsf¼DW[DÀäHs+9dPhase 3A@..DW#.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSAC4591001C4591001 1044 10441282104412821044.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWwDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòEF@Hr¡dDW[DÀäHs+9dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWFDW[.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòEF@Hr¡dDWDÏ¨Hr¼Š(DWFD¼Hsf¼DW[DÀäHs+9dPhase 3A@..DW#.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA C4591001C4591001 1044 10441282104412821044DWFDWFBUREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWwDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòEF@Hr¡dDW[DÀäHs+9dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWFDW[.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòEF@Hr¡dDWDÏ¨Hr¼Š(DWFD¼Hsf¼DW[DÀäHs+9dPhase 3A@..DW#.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA0C4591001C4591001 1044 10441282104412821044.DWwB†OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWwDW#YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòEF@Hr¡dDW[DÀäHs+9dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWFDW[.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòEF@Hr¡dDWDÏ¨Hr¼Š(DWFD¼Hsf¼DW[DÀäHs+9dPhase 3A@..DW#.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA@C4591001C4591001 1044 10441283104412831044DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW½.DW% AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD˜Hr¡ôœDWDèHr»èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD˜Hr¡ôœDWDèHr»è......Phase 3A@..DW%DW½12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1044 10441283104412831044.DW%B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW½.DW% AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD˜Hr¡ôœDWDèHr»èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD˜Hr¡ôœDWDèHr»è......Phase 3A@..DW%DW½12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1044 10441284104412841044DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DW¾DW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÖìHr¢3lDW¢DÑLHsˆäLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWDW¢.DWƒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÖìHr¢3lDWDËèHr»4èDWDÖìHsm:lDW¢DÑLHsˆäLPhase 3A@..DW".12-15 YearsA YNN. DW‚DWýDWýAðYEARSDSAC4591001C4591001 1044 10441284104412841044.DW"B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DW¾DW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÖìHr¢3lDW¢DÑLHsˆäLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWDW¢.DWƒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÖìHr¢3lDWDËèHr»4èDWDÖìHsm:lDW¢DÑLHsˆäLPhase 3A@..DW".12-15 YearsA YNN. DW‚DWýDWýAðYEARSDSA C4591001C4591001 1044 10441284104412841044DWDWB›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DW¾DW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÖìHr¢3lDW¢DÑLHsˆäLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWDW¢.DWƒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÖìHr¢3lDWDËèHr»4èDWDÖìHsm:lDW¢DÑLHsˆäLPhase 3A@..DW".12-15 YearsA YNN. DW‚DWýDWýAðYEARSDSA0C4591001C4591001 1044 10441284104412841044.DW¾BÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DW¾DW"YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÖìHr¢3lDW¢DÑLHsˆäLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DWDW¢.DWƒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÖìHr¢3lDWDËèHr»4èDWDÖìHsm:lDW¢DÑLHsˆäLPhase 3A@..DW".12-15 YearsA YNN. DW‚DWýDWýAðYEARSDSA@C4591001C4591001 1044 10441285104412851044DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¿.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDäHHr¢@ÈDWD’|Hr¼LüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDäHHr¢@ÈDWD’|Hr¼Lü......Phase 3A@..DW%DW¿12-15 YearsAYYNY. DWý.DWýAðYEARSDSAC4591001C4591001 1044 10441285104412851044.DW%B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¿.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDäHHr¢@ÈDWD’|Hr¼LüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDäHHr¢@ÈDWD’|Hr¼Lü......Phase 3A@..DW%DW¿12-15 YearsAYYNY. DWý.DWýAðYEARSDSA C4591001C4591001 1044 10441286104412861044DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDšìHr£HìDW¦D¦àHsÿàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDšìHr£HìDWDæ(Hr¼ ¨DW‘D¦,HsrO¬DW¦D¦àHsÿàPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441286104412861044.DW#B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDšìHr£HìDW¦D¦àHsÿàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDšìHr£HìDWDæ(Hr¼ ¨DW‘D¦,HsrO¬DW¦D¦àHsÿàPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441286104412861044DW‘DW‘BžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW# AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDšìHr£HìDW¦D¦àHsÿàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDšìHr£HìDWDæ(Hr¼ ¨DW‘D¦,HsrO¬DW¦D¦àHsÿàPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441286104412861044.DWÄBÑOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÄDW#YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDšìHr£HìDW¦D¦àHsÿàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDšìHr£HìDWDæ(Hr¼ ¨DW‘D¦,HsrO¬DW¦D¦àHsÿàPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441288104412881044DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DW°.DW/ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¡|Hr©æüDWDÃðHrÅ¸ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¡|Hr©æüDWDÃðHrÅ¸ð......Phase 3A@..DW/DW°12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441288104412881044.DW/B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DW°.DW/ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¡|Hr©æüDWDÃðHrÅ¸ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¡|Hr©æüDWDÃðHrÅ¸ð......Phase 3A@..DW/DW°12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441289104412891006DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÚèHrª hDWDÒHrÌ^€Placebo Placebo 12-15 YearsA . . .DVùDW.....Placebo Placebo Placebo A .Placebo A .DVùDÚèHrª hDWDÒHrÌ^€......Phase 3A@DWî.DW/.12-15 YearsA YNN. DWî.DWîAÐYEARSDSAC4591001C4591001 1044 10441289104412891006.DW/B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÚèHrª hDWDÒHrÌ^€Placebo Placebo 12-15 YearsA . . .DVùDW.....Placebo Placebo Placebo A .Placebo A .DVùDÚèHrª hDWDÒHrÌ^€......Phase 3A@DWî.DW/.12-15 YearsA YNN. DWî.DWîAÐYEARSDSA C4591001C4591001 1044 10441289104412891006.DWîBöFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT Bwithdrew consent DW/..DW/YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÚèHrª hDWDÒHrÌ^€Placebo Placebo 12-15 YearsA . . .DVùDW.....Placebo Placebo Placebo A .Placebo A .DVùDÚèHrª hDWDÒHrÌ^€......Phase 3A@DWî.DW/.12-15 YearsA YNN. DWî.DWîAÐYEARSDSAPC4591001C4591001 1044 10441290104412901044DWDVùÂSCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÚ.DWA AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÂÄHrÈZÄDW%DÃðHräpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÂÄHrÈZÄDW%DÃðHräp......Phase 3A@..DWADWÚ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441290104412901044.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÚ.DWA AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÂÄHrÈZÄDW%DÃðHräpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÂÄHrÈZÄDW%DÃðHräp......Phase 3A@..DWADWÚ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441291104412911044DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¿.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÄàHr«[àDWDê`HrÅß`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÄàHr«[àDWDê`HrÅß`......Phase 3A@..DW*DW¿12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441291104412911044.DW*B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¿.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÄàHr«[àDWDê`HrÅß`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÄàHr«[àDWDê`HrÅß`......Phase 3A@..DW*DW¿12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441292104412921044DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWƒDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÎHr«eDWcD·„Hs5¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWMDWc.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÎHr«eDW D¦,HrÄI¬DWMDÕHHsØÈDWcD·„Hs5¼Phase 3A@..DW+.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSAC4591001C4591001 1044 10441292104412921044.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWƒDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÎHr«eDWcD·„Hs5¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWMDWc.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÎHr«eDW D¦,HrÄI¬DWMDÕHHsØÈDWcD·„Hs5¼Phase 3A@..DW+.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA C4591001C4591001 1044 10441292104412921044DWMDWMBTREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWƒDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÎHr«eDWcD·„Hs5¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWMDWc.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÎHr«eDW D¦,HrÄI¬DWMDÕHHsØÈDWcD·„Hs5¼Phase 3A@..DW+.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441292104412921044.DWƒBŠOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWƒDW+YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÎHr«eDWcD·„Hs5¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWMDWc.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÎHr«eDW D¦,HrÄI¬DWMDÕHHsØÈDWcD·„Hs5¼Phase 3A@..DW+.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441293104412931044DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúE7@Hr«štDWŽDçHsnœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWŽ..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúE7@Hr«štDW DðHrÄ“€DWŽDçHsnœDWŽDçHsnœPhase 3A@..DW+.12-15 YearsA YNNDW´PROTOCOL DEVIATION DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441293104412931044.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúE7@Hr«štDWŽDçHsnœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWŽ..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúE7@Hr«štDW DðHrÄ“€DWŽDçHsnœDWŽDçHsnœPhase 3A@..DW+.12-15 YearsA YNNDW´PROTOCOL DEVIATION DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441293104412931044DWŽDWŽB•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúE7@Hr«štDWŽDçHsnœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWŽ..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúE7@Hr«štDW DðHrÄ“€DWŽDçHsnœDWŽDçHsnœPhase 3A@..DW+.12-15 YearsA YNNDW´PROTOCOL DEVIATION DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1044 10441293104412931044.DW´B»OPEN LABEL TREATMENTApDISPOSITION EVENTPROTOCOL DEVIATION A°subject received dose outside of study DW+..DW+YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúE7@Hr«štDWŽDçHsnœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWŽ..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúE7@Hr«štDW DðHrÄ“€DWŽDçHsnœDWŽDçHsnœPhase 3A@..DW+.12-15 YearsA YNNDW´PROTOCOL DEVIATION DWŒDWýDWýAÀYEARSDSA`C4591001C4591001 1044 10441294104412941044DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW¿DW+ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúE;Hr«š°DWŽDçTHsnœTPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWŽ..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúE;Hr«š°DW DïÄHrÄ“DDWŽDçTHsnœTDWŽDçTHsnœTPhase 3A@..DW+.12-15 YearsA YNNDW¿PROTOCOL DEVIATION DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441294104412941044.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW¿DW+ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúE;Hr«š°DWŽDçTHsnœTPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWŽ..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúE;Hr«š°DW DïÄHrÄ“DDWŽDçTHsnœTDWŽDçTHsnœTPhase 3A@..DW+.12-15 YearsA YNNDW¿PROTOCOL DEVIATION DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441294104412941044DWŽDWŽB•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW¿DW+ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúE;Hr«š°DWŽDçTHsnœTPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWŽ..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúE;Hr«š°DW DïÄHrÄ“DDWŽDçTHsnœTDWŽDçTHsnœTPhase 3A@..DW+.12-15 YearsA YNNDW¿PROTOCOL DEVIATION DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441294104412941044.DW¿BÆOPEN LABEL TREATMENTApDISPOSITION EVENTPROTOCOL DEVIATION A°subject received dose outside of study DW+.DW¿DW+YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúE;Hr«š°DWŽDçTHsnœTPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWŽ..DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúE;Hr«š°DW DïÄHrÄ“DDWŽDçTHsnœTDWŽDçTHsnœTPhase 3A@..DW+.12-15 YearsA YNNDW¿PROTOCOL DEVIATION DWŒDWýDWýAàYEARSDSA`C4591001C4591001 1044 10441295104412951044DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DW×.DW1 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDˆàHr¬q`DWD¬HrÈ'¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDˆàHr¬q`DWD¬HrÈ'¬......Phase 3A@..DW1DW×12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441295104412951044.DW1B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DW×.DW1 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDˆàHr¬q`DWD¬HrÈ'¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDˆàHr¬q`DWD¬HrÈ'¬......Phase 3A@..DW1DW×12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441296104412961044DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÆHr±ôŒDWD˜XHrÌ$ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÆHr±ôŒDWD˜XHrÌ$Ø......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441296104412961044.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÆHr±ôŒDWD˜XHrÌ$ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÆHr±ôŒDWD˜XHrÌ$Ø......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441297104412971044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÌ.DW1 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDˆàHr³àDWDØÌHrÏLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDˆàHr³àDWDØÌHrÏL......Phase 3A@..DW1DWÌ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441297104412971044.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÌ.DW1 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDˆàHr³àDWDØÌHrÏLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDˆàHr³àDWDØÌHrÏL......Phase 3A@..DW1DWÌ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441298104412981044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÍDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§Hr³'DW±DÁÔHsœ›TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW±.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§Hr³'DWD•ÄHrÎÅDDWœDÌØHs€öØDW±DÁÔHsœ›TPhase 3A@..DW1.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1044 10441298104412981044.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÍDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§Hr³'DW±DÁÔHsœ›TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW±.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§Hr³'DWD•ÄHrÎÅDDWœDÌØHs€öØDW±DÁÔHsœ›TPhase 3A@..DW1.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1044 10441298104412981044DWœDWœBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÍDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§Hr³'DW±DÁÔHsœ›TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW±.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§Hr³'DWD•ÄHrÎÅDDWœDÌØHs€öØDW±DÁÔHsœ›TPhase 3A@..DW1.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1044 10441298104412981044.DWÍBÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÍDW1YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§Hr³'DW±DÁÔHsœ›TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW±.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§Hr³'DWD•ÄHrÎÅDDWœDÌØHs€öØDW±DÁÔHsœ›TPhase 3A@..DW1.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1044 10441299104412991044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÃDW7 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæ Hr¹þ DW£DÒ<HsŠ6¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DW…Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæ Hr¹þ DWDÛØHrÖôXDWD‘PHslôÐDW£DÒ<HsŠ6¼Phase 3A@..DW7.12-15 YearsA YNN. DW„DWýDWýAðYEARSDSAC4591001C4591001 1044 10441299104412991044.DW7B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÃDW7 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæ Hr¹þ DW£DÒ<HsŠ6¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DW…Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæ Hr¹þ DWDÛØHrÖôXDWD‘PHslôÐDW£DÒ<HsŠ6¼Phase 3A@..DW7.12-15 YearsA YNN. DW„DWýDWýAðYEARSDSA C4591001C4591001 1044 10441299104412991044DWDWB‰REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÃDW7 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæ Hr¹þ DW£DÒ<HsŠ6¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DW…Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæ Hr¹þ DWDÛØHrÖôXDWD‘PHslôÐDW£DÒ<HsŠ6¼Phase 3A@..DW7.12-15 YearsA YNN. DW„DWýDWýAðYEARSDSA0C4591001C4591001 1044 10441299104412991044.DWÃB¿OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÃDW7YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDæ Hr¹þ DW£DÒ<HsŠ6¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW£.DW…Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDæ Hr¹þ DWDÛØHrÖôXDWD‘PHslôÐDW£DÒ<HsŠ6¼Phase 3A@..DW7.12-15 YearsA YNN. DW„DWýDWýAðYEARSDSA@C4591001C4591001 1044 10441300104413001044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÑ.DW6 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDúPHrºÐDWD¬HrÕt¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDúPHrºÐDWD¬HrÕt¬......Phase 3A@..DW6DWÑ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441300104413001044.DW6B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÑ.DW6 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDúPHrºÐDWD¬HrÕt¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDúPHrºÐDWD¬HrÕt¬......Phase 3A@..DW6DWÑ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441301104413011044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒxHr»;xDWD¢lHrÕilBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWiBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒxHr»;xDWD¢lHrÕil......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DWhDWýDWýAðYEARSDSAC4591001C4591001 1044 10441301104413011044.DW6B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒxHr»;xDWD¢lHrÕilBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWiBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒxHr»;xDWD¢lHrÕil......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DWhDWýDWýAðYEARSDSA C4591001C4591001 1044 10441302104413021044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDíäHr»VäDW¦D’@Hsë@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDíäHr»VäDWDô8Hr×¸DW‘DâhHsr‹èDW¦D’@Hsë@Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441302104413021044.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDíäHr»VäDW¦D’@Hsë@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDíäHr»VäDWDô8Hr×¸DW‘DâhHsr‹èDW¦D’@Hsë@Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441302104413021044DW‘DW‘BŒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDíäHr»VäDW¦D’@Hsë@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDíäHr»VäDWDô8Hr×¸DW‘DâhHsr‹èDW¦D’@Hsë@Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441302104413021044.DWÃB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW=YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDíäHr»VäDW¦D’@Hsë@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDíäHr»VäDWDô8Hr×¸DW‘DâhHsr‹èDW¦D’@Hsë@Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441303104413031044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWDW= AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDî\Hr»W\DWD’Hslõ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWvDW.DWrPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDî\Hr»W\DWDóüHr×|DWvDœÌHsNÌDWD’Hslõ„Phase 3A@..DW=.12-15 YearsA YNN. DWqDWýDWýAðYEARSDSAC4591001C4591001 1044 10441303104413031044.DW=B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWDW= AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDî\Hr»W\DWD’Hslõ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWvDW.DWrPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDî\Hr»W\DWDóüHr×|DWvDœÌHsNÌDWD’Hslõ„Phase 3A@..DW=.12-15 YearsA YNN. DWqDWýDWýAðYEARSDSA C4591001C4591001 1044 10441303104413031044DWvDWvBqREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWDW= AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDî\Hr»W\DWD’Hslõ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWvDW.DWrPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDî\Hr»W\DWDóüHr×|DWvDœÌHsNÌDWD’Hslõ„Phase 3A@..DW=.12-15 YearsA YNN. DWqDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441303104413031044.DWB¨OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWDW=YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDî\Hr»W\DWD’Hslõ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWvDW.DWrPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDî\Hr»W\DWDóüHr×|DWvDœÌHsNÌDWD’Hslõ„Phase 3A@..DW=.12-15 YearsA YNN. DWqDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441304104413041044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWË.DW> AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDû¸Hr»d¸DWDÓàHrÖì`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDû¸Hr»d¸DWDÓàHrÖì`......Phase 3A@..DW>DWË12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1044 10441304104413041044.DW>B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWË.DW> AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDû¸Hr»d¸DWDÓàHrÖì`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDû¸Hr»d¸DWDÓàHrÖì`......Phase 3A@..DW>DWË12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1044 10441306104413061044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¨ÀHr¼c@DWD‘PHrÕXPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¨ÀHr¼c@DWD‘PHrÕXP......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DW¬DWýDWýAÀYEARSDSAC4591001C4591001 1044 10441306104413061044.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¨ÀHr¼c@DWD‘PHrÕXPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¨ÀHr¼c@DWD‘PHrÕXP......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DW¬DWýDWýAÀYEARSDSA C4591001C4591001 1044 10441307104413071044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¨üHr¼c|DWíD`HsëƒàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWí..DWÉPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨üHr¼c|DWD‘ŒHrÕXŒDWíD`HsëƒàDWíD`HsëƒàPhase 3A@..DW=DWÉ12-15 YearsA YNN. DWÈDWýDWýAàYEARSDSAC4591001C4591001 1044 10441307104413071044.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¨üHr¼c|DWíD`HsëƒàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWí..DWÉPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨üHr¼c|DWD‘ŒHrÕXŒDWíD`HsëƒàDWíD`HsëƒàPhase 3A@..DW=DWÉ12-15 YearsA YNN. DWÈDWýDWýAàYEARSDSA C4591001C4591001 1044 10441307104413071044DWíDWíBçREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¨üHr¼c|DWíD`HsëƒàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWí..DWÉPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¨üHr¼c|DWD‘ŒHrÕXŒDWíD`HsëƒàDWíD`HsëƒàPhase 3A@..DW=DWÉ12-15 YearsA YNN. DWÈDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441308104413081044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD®`Hr¼hàDW¨DÃxHs¿xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD®`Hr¼hàDWDÚ¬HrØD¬DW‘DÆüHsrp|DW¨DÃxHs¿xPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441308104413081044.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD®`Hr¼hàDW¨DÃxHs¿xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD®`Hr¼hàDWDÚ¬HrØD¬DW‘DÆüHsrp|DW¨DÃxHs¿xPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441308104413081044DW‘DW‘B‹REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD®`Hr¼hàDW¨DÃxHs¿xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD®`Hr¼hàDWDÚ¬HrØD¬DW‘DÆüHsrp|DW¨DÃxHs¿xPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1044 10441308104413081044.DWÄB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW=YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD®`Hr¼hàDW¨DÃxHs¿xPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD®`Hr¼hàDWDÚ¬HrØD¬DW‘DÆüHsrp|DW¨DÃxHs¿xPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1044 10441309104413091044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¹ÜHr¼t\DWDÂLHrÕ‰LBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¹ÜHr¼t\DWDÂLHrÕ‰L......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DWý.DWýAÀYEARSDSAC4591001C4591001 1044 10441309104413091044.DW6B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¹ÜHr¼t\DWDÂLHrÕ‰LBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¹ÜHr¼t\DWDÂLHrÕ‰L......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DWý.DWýAÀYEARSDSA C4591001C4591001 1044 10441310104413101044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÒ.DW8 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÎ@Hr¼ˆÀDWDÉÌHrÕÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÎ@Hr¼ˆÀDWDÉÌHrÕÌ......Phase 3A@..DW8DWÒ12-15 YearsA YNY. DWý.DWýAÐYEARSDSAC4591001C4591001 1044 10441310104413101044.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÒ.DW8 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÎ@Hr¼ˆÀDWDÉÌHrÕÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÎ@Hr¼ˆÀDWDÉÌHrÕÌ......Phase 3A@..DW8DWÒ12-15 YearsA YNY. DWý.DWýAÐYEARSDSA C4591001C4591001 1044 10441311104413111044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÑ.DW= AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD—,HrÂé,DW!D’HrÞ“„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD—,HrÂé,DW!D’HrÞ“„......Phase 3A@..DW=DWÑ12-15 YearsA YNY. DWý.DWýAÀYEARSDSAC4591001C4591001 1044 10441311104413111044.DW=B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÑ.DW= AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD—,HrÂé,DW!D’HrÞ“„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD—,HrÂé,DW!D’HrÞ“„......Phase 3A@..DW=DWÑ12-15 YearsA YNY. DWý.DWýAÀYEARSDSA C4591001C4591001 1044 10441312104413121044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW½DW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD˜”HrÂê”DW¡D ÈHs‡bHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜”HrÂê”DW"D³ÄHràÄDWŽDÁ Hsnv DW¡D ÈHs‡bHPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441312104413121044.DW?B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW½DW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD˜”HrÂê”DW¡D ÈHs‡bHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜”HrÂê”DW"D³ÄHràÄDWŽDÁ Hsnv DW¡D ÈHs‡bHPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441312104413121044DWŽDWŽBƒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW½DW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD˜”HrÂê”DW¡D ÈHs‡bHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜”HrÂê”DW"D³ÄHràÄDWŽDÁ Hsnv DW¡D ÈHs‡bHPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441312104413121044.DW½B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DW½DW?YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD˜”HrÂê”DW¡D ÈHs‡bHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD˜”HrÂê”DW"D³ÄHràÄDWŽDÁ Hsnv DW¡D ÈHs‡bHPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441313104413131044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DW×.DW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§HrÂùDWíDŽ€Hsë‚Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW×DWí.DW×Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§HrÂùDW!D–<HrÞ—¼DW×D³ˆHsÎ¦DWíDŽ€Hsë‚Phase 3A@..DW?DW×12-15 YearsA YNN. DWÖDWýDWýAàYEARSDSAC4591001C4591001 1044 10441313104413131044.DW?B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DW×.DW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§HrÂùDWíDŽ€Hsë‚Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW×DWí.DW×Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§HrÂùDW!D–<HrÞ—¼DW×D³ˆHsÎ¦DWíDŽ€Hsë‚Phase 3A@..DW?DW×12-15 YearsA YNN. DWÖDWýDWýAàYEARSDSA C4591001C4591001 1044 10441313104413131044DW×DW×BÌREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?DW×.DW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§HrÂùDWíDŽ€Hsë‚Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW×DWí.DW×Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§HrÂùDW!D–<HrÞ—¼DW×D³ˆHsÎ¦DWíDŽ€Hsë‚Phase 3A@..DW?DW×12-15 YearsA YNN. DWÖDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441314104413141044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÞ.DW@ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÈdHrÃdDW!DÜPHrÞÝÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÈdHrÃdDW!DÜPHrÞÝÐ......Phase 3A@..DW@DWÞ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441314104413141044.DW@B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÞ.DW@ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÈdHrÃdDW!DÜPHrÞÝÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÈdHrÃdDW!DÜPHrÞÝÐ......Phase 3A@..DW@DWÞ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441315104413151044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈ(HrÃ(DW§DHs8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÈ(HrÃ(DW!DÜHrÞÝ”DW‘Dð´Hsrš4DW§DHs8Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441315104413151044.DW@B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈ(HrÃ(DW§DHs8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÈ(HrÃ(DW!DÜHrÞÝ”DW‘Dð´Hsrš4DW§DHs8Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441315104413151044DW‘DW‘B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈ(HrÃ(DW§DHs8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÈ(HrÃ(DW!DÜHrÞÝ”DW‘Dð´Hsrš4DW§DHs8Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441315104413151044.DWÃB¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈ(HrÃ(DW§DHs8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÈ(HrÃ(DW!DÜHrÞÝ”DW‘Dð´Hsrš4DW§DHs8Phase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441316104413161044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÛØHrÃ-ØDW!D´ðHrÞ¶pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÛØHrÃ-ØDW!D´ðHrÞ¶p......Phase 3A@..DW>DWÑ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1044 10441316104413161044.DW>B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÑ.DW> AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÛØHrÃ-ØDW!D´ðHrÞ¶pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÛØHrÃ-ØDW!D´ðHrÞ¶p......Phase 3A@..DW>DWÑ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1044 10441317104413171044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÆDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÃ4¤DW¨D¸8Hs´8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâ¤HrÃ4¤DW#DÚpHrá~ðDW“D¼4Hsu´DW¨D¸8Hs´8Phase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1044 10441317104413171044.DW?B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÆDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÃ4¤DW¨D¸8Hs´8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâ¤HrÃ4¤DW#DÚpHrá~ðDW“D¼4Hsu´DW¨D¸8Hs´8Phase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1044 10441317104413171044DW“DW“BˆREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÆDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÃ4¤DW¨D¸8Hs´8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâ¤HrÃ4¤DW#DÚpHrá~ðDW“D¼4Hsu´DW¨D¸8Hs´8Phase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441317104413171044.DWÆB»OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÆDW?YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÃ4¤DW¨D¸8Hs´8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâ¤HrÃ4¤DW#DÚpHrá~ðDW“D¼4Hsu´DW¨D¸8Hs´8Phase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441318104413181044DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DW D—àHrÄ;`DW£DÌ`HsŠ0àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D—àHrÄ;`DW!D” HrÞ• DWŽDªÜHsn_ÜDW£DÌ`HsŠ0àPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441318104413181044.DWAB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DW D—àHrÄ;`DW£DÌ`HsŠ0àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D—àHrÄ;`DW!D” HrÞ• DWŽDªÜHsn_ÜDW£DÌ`HsŠ0àPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441318104413181044DWŽDWŽB‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DW D—àHrÄ;`DW£DÌ`HsŠ0àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D—àHrÄ;`DW!D” HrÞ• DWŽDªÜHsn_ÜDW£DÌ`HsŠ0àPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441318104413181044.DWÃB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWAYAàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DW D—àHrÄ;`DW£DÌ`HsŠ0àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW D—àHrÄ;`DW!D” HrÞ• DWŽDªÜHsn_ÜDW£DÌ`HsŠ0àPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441319104413191044DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D˜HrÄ;œDW!D”\HrÞ•ÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW!....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D˜HrÄ;œDW!D”\HrÞ•Ü......Phase 3A@..DWADWÞ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441319104413191044.DWAB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D˜HrÄ;œDW!D”\HrÞ•ÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW!....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D˜HrÄ;œDW!D”\HrÞ•Ü......Phase 3A@..DWADWÞ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441320104413201044DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DµàHrÄY`DW£DÄ,HsŠ(¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DµàHrÄY`DW"D¬HrßÿDWŽDÈdHsn}dDW£DÄ,HsŠ(¬Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441320104413201044.DWEB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DµàHrÄY`DW£DÄ,HsŠ(¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DµàHrÄY`DW"D¬HrßÿDWŽDÈdHsn}dDW£DÄ,HsŠ(¬Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441320104413201044DWŽDWŽB‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DµàHrÄY`DW£DÄ,HsŠ(¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DµàHrÄY`DW"D¬HrßÿDWŽDÈdHsn}dDW£DÄ,HsŠ(¬Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441320104413201044.DW¿B³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DW¿DWEYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DµàHrÄY`DW£DÄ,HsŠ(¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DµàHrÄY`DW"D¬HrßÿDWŽDÈdHsn}dDW£DÄ,HsŠ(¬Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441321104413211044DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWß.DW> AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D¿|HrÄbüDW"DÆ„Hrà„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D¿|HrÄbüDW"DÆ„Hrà„......Phase 3A@..DW>DWß12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441321104413211044.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWß.DW> AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D¿|HrÄbüDW"DÆ„Hrà„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D¿|HrÄbüDW"DÆ„Hrà„......Phase 3A@..DW>DWß12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441322104413221044DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE..DWE AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÚ4HrÄ}´DW#Dê$HráŽ¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW#....DWNBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÚ4HrÄ}´DW#Dê$HráŽ¤......Phase 3A@DWP...12-15 YearsA YNN. DWMDWPDWPAàYEARSDSAC4591001C4591001 1044 10441322104413221044.DWEB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE..DWE AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÚ4HrÄ}´DW#Dê$HráŽ¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW#....DWNBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÚ4HrÄ}´DW#Dê$HráŽ¤......Phase 3A@DWP...12-15 YearsA YNN. DWMDWPDWPAàYEARSDSA C4591001C4591001 1044 10441322104413221044.DWPBDFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BRefused further follow-up DWE..DWEYAàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÚ4HrÄ}´DW#Dê$HráŽ¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW#....DWNBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÚ4HrÄ}´DW#Dê$HráŽ¤......Phase 3A@DWP...12-15 YearsA YNN. DWMDWPDWPAàYEARSDSA`C4591001C4591001 1044 10441323104413231044DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DóHrÄ–ŒDW§DÌHs8LPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW$.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DóHrÄ–ŒDW$DÂLHrâ¸LDW‘DððHsršpDW§DÌHs8LPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441323104413231044.DW@B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DóHrÄ–ŒDW§DÌHs8LPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW$.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DóHrÄ–ŒDW$DÂLHrâ¸LDW‘DððHsršpDW§DÌHs8LPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441323104413231044DW‘DW‘B…REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DóHrÄ–ŒDW§DÌHs8LPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW$.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DóHrÄ–ŒDW$DÂLHrâ¸LDW‘DððHsršpDW§DÌHs8LPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441323104413231044.DWÃB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DóHrÄ–ŒDW§DÌHs8LPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW$.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DóHrÄ–ŒDW$DÂLHrâ¸LDW‘DððHsršpDW§DÌHs8LPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441324104413241044DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Ed@HrÄ©ÄDW¢D’Hsˆ¥Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWŽDW¢.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Ed@HrÄ©ÄDW!DŸœHrÞ¡DWŽDÕHHsnŠHDW¢D’Hsˆ¥Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1044 10441324104413241044.DW=B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Ed@HrÄ©ÄDW¢D’Hsˆ¥Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWŽDW¢.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Ed@HrÄ©ÄDW!DŸœHrÞ¡DWŽDÕHHsnŠHDW¢D’Hsˆ¥Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1044 10441324104413241044DWŽDWŽB‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW= AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Ed@HrÄ©ÄDW¢D’Hsˆ¥Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWŽDW¢.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Ed@HrÄ©ÄDW!DŸœHrÞ¡DWŽDÕHHsnŠHDW¢D’Hsˆ¥Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441324104413241044.DWÃB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÃDW=YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Ed@HrÄ©ÄDW¢D’Hsˆ¥Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW!.DWŽDW¢.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Ed@HrÄ©ÄDW!DŸœHrÞ¡DWŽDÕHHsnŠHDW¢D’Hsˆ¥Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441325104413251044DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DW×.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW Es@HrÄª´DW"Dê$Hrà=$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW Es@HrÄª´DW"Dê$Hrà=$......Phase 3A@..DW>DW×12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441325104413251044.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DW×.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW Es@HrÄª´DW"Dê$Hrà=$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW Es@HrÄª´DW"Dê$Hrà=$......Phase 3A@..DW>DW×12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441326104413261044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHrÅˆäDW¨DÅHsÁPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD“äHrÅˆäDW!D´<HrÞµ¼DW“DÈdHsuäDW¨DÅHsÁPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1044 10441326104413261044.DW>B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHrÅˆäDW¨DÅHsÁPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD“äHrÅˆäDW!D´<HrÞµ¼DW“DÈdHsuäDW¨DÅHsÁPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1044 10441326104413261044DW“DW“B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHrÅˆäDW¨DÅHsÁPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD“äHrÅˆäDW!D´<HrÞµ¼DW“DÈdHsuäDW¨DÅHsÁPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441326104413261044.DWÉB¼OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW>YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHrÅˆäDW¨DÅHsÁPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD“äHrÅˆäDW!D´<HrÞµ¼DW“DÈdHsuäDW¨DÅHsÁPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441327104413271044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD” HrÅ‰ DW¨DÅXHsÁXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD” HrÅ‰ DW!D´xHrÞµøDW“DÈ(Hsu¨DW¨DÅXHsÁXPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1044 10441327104413271044.DW>B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD” HrÅ‰ DW¨DÅXHsÁXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD” HrÅ‰ DW!D´xHrÞµøDW“DÈ(Hsu¨DW¨DÅXHsÁXPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1044 10441327104413271044DW“DW“B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD” HrÅ‰ DW¨DÅXHsÁXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD” HrÅ‰ DW!D´xHrÞµøDW“DÈ(Hsu¨DW¨DÅXHsÁXPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA0C4591001C4591001 1044 10441327104413271044.DWÉB¼OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW>YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD” HrÅ‰ DW¨DÅXHsÁXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD” HrÅ‰ DW!D´xHrÞµøDW“DÈ(Hsu¨DW¨DÅXHsÁXPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA@C4591001C4591001 1044 10441328104413281044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWß.DW> AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¦àHrÅ›àDW"D‘PHrßäPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¦àHrÅ›àDW"D‘PHrßäP......Phase 3A@..DW>DWß12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441328104413281044.DW>B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWß.DW> AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¦àHrÅ›àDW"D‘PHrßäPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¦àHrÅ›àDW"D‘PHrßäP......Phase 3A@..DW>DWß12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441329104413291044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWæ.DWA AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÃxHrÅ¸xDW#DàˆHrá…BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÃxHrÅ¸xDW#DàˆHrá…......Phase 3A@..DWADWæ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441329104413291044.DWAB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWæ.DWA AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÃxHrÅ¸xDW#DàˆHrá…BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÃxHrÅ¸xDW#DàˆHrá…......Phase 3A@..DWADWæ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441330104413301044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙDHrÅÎDDW§DËèHsvhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙDHrÅÎDDW#DÑˆHrávDW“D¶HsuœDW§DËèHsvhPhase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSAC4591001C4591001 1044 10441330104413301044.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙDHrÅÎDDW§DËèHsvhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙDHrÅÎDDW#DÑˆHrávDW“D¶HsuœDW§DËèHsvhPhase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA C4591001C4591001 1044 10441330104413301044DW“DW“B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙDHrÅÎDDW§DËèHsvhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙDHrÅÎDDW#DÑˆHrávDW“D¶HsuœDW§DËèHsvhPhase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA0C4591001C4591001 1044 10441330104413301044.DWÄB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW?YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙDHrÅÎDDW§DËèHsvhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW§.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙDHrÅÎDDW#DÑˆHrávDW“D¶HsuœDW§DËèHsvhPhase 3A@..DW?.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA@C4591001C4591001 1044 10441331104413311044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDW×.DWE AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDøèHrÅíèDW#DêœHráBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDøèHrÅíèDW#DêœHrá......Phase 3A@..DWEDW×12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441331104413311044.DWEB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDW×.DWE AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDøèHrÅíèDW#DêœHráBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDøèHrÅíèDW#DêœHrá......Phase 3A@..DWEDW×12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441332104413321044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDù$HrÅî$DW£DäHHsŠHÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDù$HrÅî$DW#DêØHráXDWŽDÉHsn~DW£DäHHsŠHÈPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1044 10441332104413321044.DWEB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDù$HrÅî$DW£DäHHsŠHÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDù$HrÅî$DW#DêØHráXDWŽDÉHsn~DW£DäHHsŠHÈPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1044 10441332104413321044DWŽDWŽBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDù$HrÅî$DW£DäHHsŠHÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDù$HrÅî$DW#DêØHráXDWŽDÉHsn~DW£DäHHsŠHÈPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441332104413321044.DWÃB¶OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWEYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDù$HrÅî$DW£DäHHsŠHÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDù$HrÅî$DW#DêØHráXDWŽDÉHsn~DW£DäHHsŠHÈPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441333104413331044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÒ.DWA AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWE†HrÅý`DW#DÍHráq”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWE†HrÅý`DW#DÍHráq”......Phase 3A@..DWADWÒ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441333104413331044.DWAB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÒ.DWA AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWE†HrÅý`DW#DÍHráq”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWE†HrÅý`DW#DÍHráq”......Phase 3A@..DWADWÒ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441334104413341044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWß.DWH AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD’@HrÆØÀDW"DŽøHrßáøBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD’@HrÆØÀDW"DŽøHrßáø......Phase 3A@..DWHDWß12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441334104413341044.DWHB:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWß.DWH AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD’@HrÆØÀDW"DŽøHrßáøBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD’@HrÆØÀDW"DŽøHrßáø......Phase 3A@..DWHDWß12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441335104413351044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÄDWH AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙ¼HrÇ <DW¦Dæ(HsŽ?(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙ¼HrÇ <DW%D× Hrä DW’DêœHssåœDW¦Dæ(HsŽ?(Phase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1044 10441335104413351044.DWHB:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÄDWH AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙ¼HrÇ <DW¦Dæ(HsŽ?(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙ¼HrÇ <DW%D× Hrä DW’DêœHssåœDW¦Dæ(HsŽ?(Phase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1044 10441335104413351044DW’DW’B„REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÄDWH AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙ¼HrÇ <DW¦Dæ(HsŽ?(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙ¼HrÇ <DW%D× Hrä DW’DêœHssåœDW¦Dæ(HsŽ?(Phase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441335104413351044.DWÄB¶OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÄDWHYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÙ¼HrÇ <DW¦Dæ(HsŽ?(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÙ¼HrÇ <DW%D× Hrä DW’DêœHssåœDW¦Dæ(HsŽ?(Phase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441336104413361044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWØ.DW@ AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDé4HrÇ/´DW$Dä„HrâÚ„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDé4HrÇ/´DW$Dä„HrâÚ„......Phase 3A@..DW@DWØ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441336104413361044.DW@B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWØ.DW@ AÀYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDé4HrÇ/´DW$Dä„HrâÚ„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDé4HrÇ/´DW$Dä„HrâÚ„......Phase 3A@..DW@DWØ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441337104413371044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD$HrÈ($DW¦D¦hHsÿhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD$HrÈ($DW%D“¨HrãÛ(DW“D–<Hstâ¼DW¦D¦hHsÿhPhase 3A@..DWA.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441337104413371044.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD$HrÈ($DW¦D¦hHsÿhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD$HrÈ($DW%D“¨HrãÛ(DW“D–<Hstâ¼DW¦D¦hHsÿhPhase 3A@..DWA.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441337104413371044DW“DW“B„REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD$HrÈ($DW¦D¦hHsÿhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD$HrÈ($DW%D“¨HrãÛ(DW“D–<Hstâ¼DW¦D¦hHsÿhPhase 3A@..DWA.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441337104413371044.DWÃB´OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWAYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD$HrÈ($DW¦D¦hHsÿhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD$HrÈ($DW%D“¨HrãÛ(DW“D–<Hstâ¼DW¦D¦hHsÿhPhase 3A@..DWA.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441338104413381044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD$HrÈ($DW%D¢0Hrãé°Placebo Placebo 12-15 YearsA . . .DWDW%.....Placebo Placebo Placebo A .Placebo A .DWD$HrÈ($DW%D¢0Hrãé°......Phase 3A@..DWADWÙ12-15 YearsA YNN. DWý.DWýAÐYEARSDSAC4591001C4591001 1044 10441338104413381044.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD$HrÈ($DW%D¢0Hrãé°Placebo Placebo 12-15 YearsA . . .DWDW%.....Placebo Placebo Placebo A .Placebo A .DWD$HrÈ($DW%D¢0Hrãé°......Phase 3A@..DWADWÙ12-15 YearsA YNN. DWý.DWýAÐYEARSDSA C4591001C4591001 1044 10441339104413391044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWß.DWE AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDáxHrÈyxDW%DÝôHrä%tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDáxHrÈyxDW%DÝôHrä%t......Phase 3A@..DWEDWß12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441339104413391044.DWEB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWß.DWE AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDáxHrÈyxDW%DÝôHrä%tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDáxHrÈyxDW%DÝôHrä%t......Phase 3A@..DWEDWß12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441340104413401044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâhHrÈzhDW D¦,Hs†,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâhHrÈzhDW%Dß\Hrä&ÜDWDÝôHsmAtDW D¦,Hs†,Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441340104413401044.DWEB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâhHrÈzhDW D¦,Hs†,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâhHrÈzhDW%Dß\Hrä&ÜDWDÝôHsmAtDW D¦,Hs†,Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441340104413401044DWDWB~REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâhHrÈzhDW D¦,Hs†,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâhHrÈzhDW%Dß\Hrä&ÜDWDÝôHsmAtDW D¦,Hs†,Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441340104413401044.DWÃB´OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWEYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâhHrÈzhDW D¦,Hs†,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâhHrÈzhDW%Dß\Hrä&ÜDWDÝôHsmAtDW D¦,Hs†,Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441341104413411044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÈz¤DW D¦hHs†hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâ¤HrÈz¤DW%DßÔHrä'TDWDÝôHsmAtDW D¦hHs†hPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441341104413411044.DWEB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÈz¤DW D¦hHs†hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâ¤HrÈz¤DW%DßÔHrä'TDWDÝôHsmAtDW D¦hHs†hPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441341104413411044DWDWB~REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÈz¤DW D¦hHs†hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâ¤HrÈz¤DW%DßÔHrä'TDWDÝôHsmAtDW D¦hHs†hPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441341104413411044.DWÃB´OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWEYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDâ¤HrÈz¤DW D¦hHs†hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDâ¤HrÈz¤DW%DßÔHrä'TDWDÝôHsmAtDW D¦hHs†hPhase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441342104413421044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÓ.DWD AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‘PHrÉzÐDW$DÚ¬HrâÐ¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‘PHrÉzÐDW$DÚ¬HrâÐ¬......Phase 3A@..DWDDWÓ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441342104413421044.DWDB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÓ.DWD AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‘PHrÉzÐDW$DÚ¬HrâÐ¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‘PHrÉzÐDW$DÚ¬HrâÐ¬......Phase 3A@..DWDDWÓ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441343104413431044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÚ.DWA AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD’@HrÉ{ÀDW%DÙHrä ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD’@HrÉ{ÀDW%DÙHrä ˆ......Phase 3A@..DWADWÚ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441343104413431044.DWAB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÚ.DWA AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD’@HrÉ{ÀDW%DÙHrä ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD’@HrÉ{ÀDW%DÙHrä ˆ......Phase 3A@..DWADWÚ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441344104413441044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED ..DWoDW9 AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD’HrÉ{„DWSD”˜Hs Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW:DWS.DW1Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD’HrÉ{„DW%DØÌHrä LDW:D³LHrÿªLDWSD”˜Hs Phase 3A@.DW/..12-15 YearsA YNN. DW0DWýDWýAðYEARSDSAC4591001C4591001 1044 10441344104413441044DW:DW:B*REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED ..DWoDW9 AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD’HrÉ{„DWSD”˜Hs Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW:DWS.DW1Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD’HrÉ{„DW%DØÌHrä LDW:D³LHrÿªLDWSD”˜Hs Phase 3A@.DW/..12-15 YearsA YNN. DW0DWýDWýAðYEARSDSA C4591001C4591001 1044 10441344104413441044.DWoB_OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED ..DWoDW9YAðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD’HrÉ{„DWSD”˜Hs Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW:DWS.DW1Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD’HrÉ{„DW%DØÌHrä LDW:D³LHrÿªLDWSD”˜Hs Phase 3A@.DW/..12-15 YearsA YNN. DW0DWýDWýAðYEARSDSA0C4591001C4591001 1044 10441344104413441044.DW/BVACCINATION BDISPOSITION EVENTOTHER Aptransitioning to open label ..DWoDW9 AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD’HrÉ{„DWSD”˜Hs Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW:DWS.DW1Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD’HrÉ{„DW%DØÌHrä LDW:D³LHrÿªLDWSD”˜Hs Phase 3A@.DW/..12-15 YearsA YNN. DW0DWýDWýAðYEARSDSA`C4591001C4591001 1044 10441345104413451044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¢äHrÉŒdDW¦D“0Hsì0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¢äHrÉŒdDW$DÞ0HrâÔ0DW‘D™üHsrC|DW¦D“0Hsì0Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441345104413451044.DWEB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¢äHrÉŒdDW¦D“0Hsì0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¢äHrÉŒdDW$DÞ0HrâÔ0DW‘D™üHsrC|DW¦D“0Hsì0Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441345104413451044DW‘DW‘BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¢äHrÉŒdDW¦D“0Hsì0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¢äHrÉŒdDW$DÞ0HrâÔ0DW‘D™üHsrC|DW¦D“0Hsì0Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1044 10441345104413451044.DWÃB³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWEYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¢äHrÉŒdDW¦D“0Hsì0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¢äHrÉŒdDW$DÞ0HrâÔ0DW‘D™üHsrC|DW¦D“0Hsì0Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1044 10441346104413461044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDW×.DWE AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¢lHrÉ‹ìDW$D¬Hrâ…¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¢lHrÉ‹ìDW$D¬Hrâ…¬......Phase 3A@..DWEDW×12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441346104413461044.DWEB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDW×.DWE AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¢lHrÉ‹ìDW$D¬Hrâ…¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¢lHrÉ‹ìDW$D¬Hrâ…¬......Phase 3A@..DWEDW×12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441347104413471044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£˜HrÉDW%D·ÀHrãÿ@Placebo Placebo 12-15 YearsA . . .DWDW%....DWŽPlacebo Placebo Placebo A .Placebo A .DWD£˜HrÉDW%D·ÀHrãÿ@......Phase 3A@DWœ.DWF.12-15 YearsA YNN. DWDWœDWœAàYEARSDSAC4591001C4591001 1044 10441347104413471044.DWFB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£˜HrÉDW%D·ÀHrãÿ@Placebo Placebo 12-15 YearsA . . .DWDW%....DWŽPlacebo Placebo Placebo A .Placebo A .DWD£˜HrÉDW%D·ÀHrãÿ@......Phase 3A@DWœ.DWF.12-15 YearsA YNN. DWDWœDWœAàYEARSDSA C4591001C4591001 1044 10441347104413471044.DWœBŒFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BParent/guardian contacted the site to advise that her daughter is no longer interested in continuingDWF..DWFYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£˜HrÉDW%D·ÀHrãÿ@Placebo Placebo 12-15 YearsA . . .DWDW%....DWŽPlacebo Placebo Placebo A .Placebo A .DWD£˜HrÉDW%D·ÀHrãÿ@......Phase 3A@DWœ.DWF.12-15 YearsA YNN. DWDWœDWœAàYEARSDSA`C4591001C4591001 1044 10441348104413481044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬€HrÉ–DW§DàLHsŠÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬€HrÉ–DW$DÑÄHrâÇÄDW‘DÜPHsr…ÐDW§DàLHsŠÌPhase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441348104413481044.DW@B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬€HrÉ–DW§DàLHsŠÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬€HrÉ–DW$DÑÄHrâÇÄDW‘DÜPHsr…ÐDW§DàLHsŠÌPhase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441348104413481044DW‘DW‘BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬€HrÉ–DW§DàLHsŠÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬€HrÉ–DW$DÑÄHrâÇÄDW‘DÜPHsr…ÐDW§DàLHsŠÌPhase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441348104413481044.DWÃB³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÃDW@YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬€HrÉ–DW§DàLHsŠÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬€HrÉ–DW$DÑÄHrâÇÄDW‘DÜPHsr…ÐDW§DàLHsŠÌPhase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441349104413491044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD4HrÉ–´DW%D’¸HrãÚ8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD4HrÉ–´DW%D’¸HrãÚ8......Phase 3A@..DWADWÞ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441349104413491044.DWAB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÞ.DWA AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD4HrÉ–´DW%D’¸HrãÚ8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD4HrÉ–´DW%D’¸HrãÚ8......Phase 3A@..DWADWÞ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441350104413501044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWØ.DWA AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD´HrÉ€DW%D°ôHrãøtBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWuBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD´HrÉ€DW%D°ôHrãøt......Phase 3A@..DWADWØ12-15 YearsA YNY. DWtDWýDWýAðYEARSDSAC4591001C4591001 1044 10441350104413501044.DWAB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWØ.DWA AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD´HrÉ€DW%D°ôHrãøtBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWuBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD´HrÉ€DW%D°ôHrãøt......Phase 3A@..DWADWØ12-15 YearsA YNY. DWtDWýDWýAðYEARSDSA C4591001C4591001 1044 10441351104413511044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWGDWÚ.DWG AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽ¼HrÊÉ¼DWóDß Hsó» Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWßDWó.DWÚPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŽ¼HrÊÉ¼DW(DáHrèDWßDåtHsÙcôDWóDß Hsó» Phase 3A@..DWGDWÚ12-15 YearsA YNN. DWÙDWýDWýAðYEARSDSAC4591001C4591001 1044 10441351104413511044.DWGB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWGDWÚ.DWG AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽ¼HrÊÉ¼DWóDß Hsó» Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWßDWó.DWÚPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŽ¼HrÊÉ¼DW(DáHrèDWßDåtHsÙcôDWóDß Hsó» Phase 3A@..DWGDWÚ12-15 YearsA YNN. DWÙDWýDWýAðYEARSDSA C4591001C4591001 1044 10441351104413511044DWßDWßBÎREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWGDWÚ.DWG AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŽ¼HrÊÉ¼DWóDß Hsó» Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWßDWó.DWÚPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDŽ¼HrÊÉ¼DW(DáHrèDWßDåtHsÙcôDWóDß Hsó» Phase 3A@..DWGDWÚ12-15 YearsA YNN. DWÙDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441352104413521044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWá.DWE AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD`HrÊË`DW%D¶ÐHrãþPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD`HrÊË`DW%D¶ÐHrãþP......Phase 3A@..DWEDWá12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441352104413521044.DWEB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWá.DWE AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD`HrÊË`DW%D¶ÐHrãþPBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD`HrÊË`DW%D¶ÐHrãþP......Phase 3A@..DWEDWá12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441353104413531044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÚ.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‘HrÊÌDW(DÚ¬Hrè¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‘HrÊÌDW(DÚ¬Hrè¬......Phase 3A@..DWDDWÚ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441353104413531044.DWDB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÚ.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‘HrÊÌDW(DÚ¬Hrè¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‘HrÊÌDW(DÚ¬Hrè¬......Phase 3A@..DWDDWÚ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441354104413541044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÆDWA AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¢lHrÊÝlDW¨DèHs‹èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¢lHrÊÝlDW%D² Hrãù DW“D•ˆHstâDW¨DèHs‹èPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441354104413541044.DWAB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÆDWA AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¢lHrÊÝlDW¨DèHs‹èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¢lHrÊÝlDW%D² Hrãù DW“D•ˆHstâDW¨DèHs‹èPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441354104413541044DW“DW“B‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÆDWA AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¢lHrÊÝlDW¨DèHs‹èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¢lHrÊÝlDW%D² Hrãù DW“D•ˆHstâDW¨DèHs‹èPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441354104413541044.DWÆBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÆDWAYAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¢lHrÊÝlDW¨DèHs‹èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¢lHrÊÝlDW%D² Hrãù DW“D•ˆHstâDW¨DèHs‹èPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441355104413551044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¢¨HrÊÝ¨DW%D²˜HrãúBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¢¨HrÊÝ¨DW%D²˜Hrãú......Phase 3A@..DWADWÙ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441355104413551044.DWAB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¢¨HrÊÝ¨DW%D²˜HrãúBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¢¨HrÊÝ¨DW%D²˜Hrãú......Phase 3A@..DWADWÙ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441356104413561044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWKDWÚ.DWK AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£˜HrÊÞ˜DW)DôìHré‚lPlacebo Placebo 12-15 YearsA . . .DWDW).....Placebo Placebo Placebo A .Placebo A .DWD£˜HrÊÞ˜DW)DôìHré‚l......Phase 3A@..DWKDWÚ12-15 YearsA YNN. DWý.DWýAÀYEARSDSAC4591001C4591001 1044 10441356104413561044.DWKB:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWKDWÚ.DWK AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£˜HrÊÞ˜DW)DôìHré‚lPlacebo Placebo 12-15 YearsA . . .DWDW).....Placebo Placebo Placebo A .Placebo A .DWD£˜HrÊÞ˜DW)DôìHré‚l......Phase 3A@..DWKDWÚ12-15 YearsA YNN. DWý.DWýAÀYEARSDSA C4591001C4591001 1044 10441357104413571044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÄDWH AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°¸HrÊë¸DW¦DædHsŽ?dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°¸HrÊë¸DW%D×dHrääDW’DêØHssåØDW¦DædHsŽ?dPhase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441357104413571044.DWHB7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÄDWH AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°¸HrÊë¸DW¦DædHsŽ?dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°¸HrÊë¸DW%D×dHrääDW’DêØHssåØDW¦DædHsŽ?dPhase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441357104413571044DW’DW’BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÄDWH AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°¸HrÊë¸DW¦DædHsŽ?dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°¸HrÊë¸DW%D×dHrääDW’DêØHssåØDW¦DædHsŽ?dPhase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441357104413571044.DWÄB³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÄDWHYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°¸HrÊë¸DW¦DædHsŽ?dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°¸HrÊë¸DW%D×dHrääDW’DêØHssåØDW¦DædHsŽ?dPhase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441358104413581044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWå.DWH AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD°HrÊëDW(D¼¬Hrçø¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD°HrÊëDW(D¼¬Hrçø¬......Phase 3A@..DWHDWå12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1044 10441358104413581044.DWHB7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWå.DWH AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD°HrÊëDW(D¼¬Hrçø¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD°HrÊëDW(D¼¬Hrçø¬......Phase 3A@..DWHDWå12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1044 10441359104413591044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW\DWó.DW\ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌHrÌLDW@DíäHsÍäBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW@....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌHrÌLDW@DíäHsÍä......Phase 3A@..DW\DWó12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1044 10441359104413591044.DW\BJVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW\DWó.DW\ AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌHrÌLDW@DíäHsÍäBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW@....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌHrÌLDW@DíäHsÍä......Phase 3A@..DW\DWó12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1044 10441360104413601044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW\.DWÄDW\ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDHrÌDW¦DêØHsŽCØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW@.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDHrÌDW@Dî HsÎ DW‘D—¤HsrA$DW¦DêØHsŽCØPhase 3A@..DW\.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441360104413601044.DW\BJVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW\.DWÄDW\ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDHrÌDW¦DêØHsŽCØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW@.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDHrÌDW@Dî HsÎ DW‘D—¤HsrA$DW¦DêØHsŽCØPhase 3A@..DW\.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441360104413601044DW‘DW‘BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW\.DWÄDW\ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDHrÌDW¦DêØHsŽCØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW@.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDHrÌDW@Dî HsÎ DW‘D—¤HsrA$DW¦DêØHsŽCØPhase 3A@..DW\.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441360104413601044.DWÄB²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW\.DWÄDW\YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDHrÌDW¦DêØHsŽCØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW@.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDHrÌDW@Dî HsÎ DW‘D—¤HsrA$DW¦DêØHsŽCØPhase 3A@..DW\.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441361104413611044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWLDWÙ.DWL AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD²ÔHrÌ?TDW*D¶Hrê•BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD²ÔHrÌ?TDW*D¶Hrê•......Phase 3A@..DWLDWÙ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1044 10441361104413611044.DWLB:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWLDWÙ.DWL AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD²ÔHrÌ?TDW*D¶Hrê•BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD²ÔHrÌ?TDW*D¶Hrê•......Phase 3A@..DWLDWÙ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1044 10441362104413621044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWG.DW¿DWG AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÂÄHrÌODDW£DÑHsŠ5Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÂÄHrÌODDW*D˜XHrêwXDWDçHsmKDW£DÑHsŠ5Phase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441362104413621044.DWGB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DW¿DWG AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÂÄHrÌODDW£DÑHsŠ5Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÂÄHrÌODDW*D˜XHrêwXDWDçHsmKDW£DÑHsŠ5Phase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441362104413621044DWDWB{REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DW¿DWG AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÂÄHrÌODDW£DÑHsŠ5Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÂÄHrÌODDW*D˜XHrêwXDWDçHsmKDW£DÑHsŠ5Phase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441362104413621044.DW¿BOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DW¿DWGYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÂÄHrÌODDW£DÑHsŠ5Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÂÄHrÌODDW*D˜XHrêwXDWDçHsmKDW£DÑHsŠ5Phase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441363104413631044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWF AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÎôHrÌ[tDW£DÝHsŠA„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÎôHrÌ[tDW(DÅXHrèXDWŽDÚpHsnpDW£DÝHsŠA„Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441363104413631044.DWFB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWF AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÎôHrÌ[tDW£DÝHsŠA„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÎôHrÌ[tDW(DÅXHrèXDWŽDÚpHsnpDW£DÝHsŠA„Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441363104413631044DWŽDWŽB|REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWF AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÎôHrÌ[tDW£DÝHsŠA„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÎôHrÌ[tDW(DÅXHrèXDWŽDÚpHsnpDW£DÝHsŠA„Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441363104413631044.DWÃB±OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWFYAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÎôHrÌ[tDW£DÝHsŠA„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÎôHrÌ[tDW(DÅXHrèXDWŽDÚpHsnpDW£DÝHsŠA„Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441364104413641044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWGDWà.DWG AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÖ°HrÌc0DW*DÚèHrê¹èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÖ°HrÌc0DW*DÚèHrê¹è......Phase 3A@..DWGDWà12-15 YearsA YNY. DW“DWýDWýAðYEARSDSAC4591001C4591001 1044 10441364104413641044.DWGB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWGDWà.DWG AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÖ°HrÌc0DW*DÚèHrê¹èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÖ°HrÌc0DW*DÚèHrê¹è......Phase 3A@..DWGDWà12-15 YearsA YNY. DW“DWýDWýAðYEARSDSA C4591001C4591001 1044 10441365104413651044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWF AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜÈHrÌiHDW¡D”\Hs‡UÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜÈHrÌiHDW)D×ÜHrée\DWDÃxHsm&øDW¡D”\Hs‡UÜPhase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441365104413651044.DWFB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWF AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜÈHrÌiHDW¡D”\Hs‡UÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜÈHrÌiHDW)D×ÜHrée\DWDÃxHsm&øDW¡D”\Hs‡UÜPhase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441365104413651044DWDWB{REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWF AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜÈHrÌiHDW¡D”\Hs‡UÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜÈHrÌiHDW)D×ÜHrée\DWDÃxHsm&øDW¡D”\Hs‡UÜPhase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441365104413651044.DWÃB±OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWFYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜÈHrÌiHDW¡D”\Hs‡UÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜÈHrÌiHDW)D×ÜHrée\DWDÃxHsm&øDW¡D”\Hs‡UÜPhase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441366104413661044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÞ.DWF AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÜPHrÌhÐDW)D× Hrée BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÜPHrÌhÐDW)D× Hrée ......Phase 3A@..DWFDWÞ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441366104413661044.DWFB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÞ.DWF AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÜPHrÌhÐDW)D× Hrée BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÜPHrÌhÐDW)D× Hrée ......Phase 3A@..DWFDWÞ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441367104413671044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWLDWÙ.DWL AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDî HrÌz DW*D¨„Hrê‡„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDî HrÌz DW*D¨„Hrê‡„......Phase 3A@..DWLDWÙ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441367104413671044.DWLB:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWLDWÙ.DWL AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDî HrÌz DW*D¨„Hrê‡„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDî HrÌz DW*D¨„Hrê‡„......Phase 3A@..DWLDWÙ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441368104413681044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWL.DW}DWL AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDõ HrÌ‚ DWaDØTHs39ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWLDWa.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDõ HrÌ‚ DW*DÃ´Hrê¢´DWLDÛ`Hs`DWaDØTHs39ÔPhase 3A@..DWL.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSAC4591001C4591001 1044 10441368104413681044DWLDWLB:REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWL.DW}DWL AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDõ HrÌ‚ DWaDØTHs39ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWLDWa.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDõ HrÌ‚ DW*DÃ´Hrê¢´DWLDÛ`Hs`DWaDØTHs39ÔPhase 3A@..DWL.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA C4591001C4591001 1044 10441368104413681044.DWLB:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWL.DW}DWL AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDõ HrÌ‚ DWaDØTHs39ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWLDWa.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDõ HrÌ‚ DW*DÃ´Hrê¢´DWLDÛ`Hs`DWaDØTHs39ÔPhase 3A@..DWL.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441368104413681044.DW}BkOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWL.DW}DWLYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDõ HrÌ‚ DWaDØTHs39ÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWLDWa.DWKPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDõ HrÌ‚ DW*DÃ´Hrê¢´DWLDÛ`Hs`DWaDØTHs39ÔPhase 3A@..DWL.12-15 YearsA YNN. DWJDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441369104413691044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWß.DWF AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDùœHrÌ†DW)Dí¨Hré{(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDùœHrÌ†DW)Dí¨Hré{(......Phase 3A@..DWFDWß12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441369104413691044.DWFB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWß.DWF AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDùœHrÌ†DW)Dí¨Hré{(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDùœHrÌ†DW)Dí¨Hré{(......Phase 3A@..DWFDWß12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441370104413701044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÑDWF AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDù`HrÌ…àDW´DŸ$Hs m$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDù`HrÌ…àDW)DílHrézìDW DÐ\Hs†@\DW´DŸ$Hs m$Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441370104413701044.DWFB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÑDWF AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDù`HrÌ…àDW´DŸ$Hs m$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDù`HrÌ…àDW)DílHrézìDW DÐ\Hs†@\DW´DŸ$Hs m$Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441370104413701044DW DW BŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÑDWF AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDù`HrÌ…àDW´DŸ$Hs m$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDù`HrÌ…àDW)DílHrézìDW DÐ\Hs†@\DW´DŸ$Hs m$Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1044 10441370104413701044.DWÑB¿OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÑDWFYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDù`HrÌ…àDW´DŸ$Hs m$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDù`HrÌ…àDW)DílHrézìDW DÐ\Hs†@\DW´DŸ$Hs m$Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1044 10441371104413711044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWH..DWH AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWEkÀHrÌ“<DW)DÆÀHréT@Placebo Placebo 12-15 YearsA . . .DWDW).....Placebo Placebo Placebo A .Placebo A .DWEkÀHrÌ“<DW)DÆÀHréT@......Phase 3A@DWß.DWH.12-15 YearsA YNN. DWß.DWßAðYEARSDSAC4591001C4591001 1044 10441371104413711044.DWHB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWH..DWH AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWEkÀHrÌ“<DW)DÆÀHréT@Placebo Placebo 12-15 YearsA . . .DWDW).....Placebo Placebo Placebo A .Placebo A .DWEkÀHrÌ“<DW)DÆÀHréT@......Phase 3A@DWß.DWH.12-15 YearsA YNN. DWß.DWßAðYEARSDSA C4591001C4591001 1044 10441371104413711044.DWßBÍFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT Bsubject moved from area DWH..DWHYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWEkÀHrÌ“<DW)DÆÀHréT@Placebo Placebo 12-15 YearsA . . .DWDW).....Placebo Placebo Placebo A .Placebo A .DWEkÀHrÌ“<DW)DÆÀHréT@......Phase 3A@DWß.DWH.12-15 YearsA YNN. DWß.DWßAðYEARSDSAPC4591001C4591001 1044 10441372104413721044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWH..DWH AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWEhHrÌ“DW)DÆ„HréTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWEhHrÌ“DW)DÆ„HréT......Phase 3A@DWß.DWH.12-15 YearsA YNY. DWŒDWßDWßAÐYEARSDSAC4591001C4591001 1044 10441372104413721044.DWHB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWH..DWH AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWEhHrÌ“DW)DÆ„HréTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWEhHrÌ“DW)DÆ„HréT......Phase 3A@DWß.DWH.12-15 YearsA YNY. DWŒDWßDWßAÐYEARSDSA C4591001C4591001 1044 10441372104413721044.DWßBÍFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT Bsubject moved from area DWH..DWHYAÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWEhHrÌ“DW)DÆ„HréTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWEhHrÌ“DW)DÆ„HréT......Phase 3A@DWß.DWH.12-15 YearsA YNY. DWŒDWßDWßAÐYEARSDSA`C4591001C4591001 1044 10441373104413731044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWL.DWÄDWL AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD”\HrÍr\DW§D‡<Hs1¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW+.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD”\HrÍr\DW+DHrë¾DW‘D–´Hsr@4DW§D‡<Hs1¼Phase 3A@..DWL.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441373104413731044.DWLB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWL.DWÄDWL AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD”\HrÍr\DW§D‡<Hs1¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW+.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD”\HrÍr\DW+DHrë¾DW‘D–´Hsr@4DW§D‡<Hs1¼Phase 3A@..DWL.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441373104413731044DW‘DW‘B~REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWL.DWÄDWL AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD”\HrÍr\DW§D‡<Hs1¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW+.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD”\HrÍr\DW+DHrë¾DW‘D–´Hsr@4DW§D‡<Hs1¼Phase 3A@..DWL.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1044 10441373104413731044.DWÄB±OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWL.DWÄDWLYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD”\HrÍr\DW§D‡<Hs1¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW+.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD”\HrÍr\DW+DHrë¾DW‘D–´Hsr@4DW§D‡<Hs1¼Phase 3A@..DWL.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1044 10441374104413741044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWØ.DWF AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£ HrÍ DWðD PHsïˆPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWð..DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£ HrÍ DW)D•LHré"ÌDWðD PHsïˆPDWðD PHsïˆPPhase 3A@..DWFDWØ12-15 YearsA YNN. DW×DWýDWýAðYEARSDSAC4591001C4591001 1044 10441374104413741044.DWFB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWØ.DWF AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£ HrÍ DWðD PHsïˆPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWð..DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£ HrÍ DW)D•LHré"ÌDWðD PHsïˆPDWðD PHsïˆPPhase 3A@..DWFDWØ12-15 YearsA YNN. DW×DWýDWýAðYEARSDSA C4591001C4591001 1044 10441374104413741044DWðDWðBÝREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWØ.DWF AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD£ HrÍ DWðD PHsïˆPPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DWð..DWØPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD£ HrÍ DW)D•LHré"ÌDWðD PHsïˆPDWðD PHsïˆPPhase 3A@..DWFDWØ12-15 YearsA YNN. DW×DWýDWýAðYEARSDSA0C4591001C4591001 1044 10441375104413751044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWÚ.DWE AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD²˜HrÍ˜DW)D¡¸Hré/8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD²˜HrÍ˜DW)D¡¸Hré/8......Phase 3A@..DWEDWÚ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441375104413751044.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWÚ.DWE AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD²˜HrÍ˜DW)D¡¸Hré/8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD²˜HrÍ˜DW)D¡¸Hré/8......Phase 3A@..DWEDWÚ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441376104413761044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWÚ.DWE AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD²ÔHrÍÔDW)D¡|Hré.üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD²ÔHrÍÔDW)D¡|Hré.ü......Phase 3A@..DWEDWÚ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1044 10441376104413761044.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWÚ.DWE AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD²ÔHrÍÔDW)D¡|Hré.üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD²ÔHrÍÔDW)D¡|Hré.ü......Phase 3A@..DWEDWÚ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1044 10441377104413771044DWDWÂSCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWYDWõ.DWY AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW(D½œHrçùœDW=DÜPHsÇÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW(DW=....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW(D½œHrçùœDW=DÜPHsÇÐ......Phase 3A@..DWYDWõ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441377104413771044.DWYB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWYDWõ.DWY AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW(D½œHrçùœDW=DÜPHsÇÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW(DW=....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW(D½œHrçùœDW=DÜPHsÇÐ......Phase 3A@..DWYDWõ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441378104413781044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWKDWÞ.DWK AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌ$HrÍª$DW+DàLHrìÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW+....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌ$HrÍª$DW+DàLHrìÌ......Phase 3A@..DWKDWÞ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441378104413781044.DWKB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWKDWÞ.DWK AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌ$HrÍª$DW+DàLHrìÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW+....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌ$HrÍª$DW+DàLHrìÌ......Phase 3A@..DWKDWÞ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441379104413791044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWKDWÞ.DWK AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌ`HrÍª`DW+DàˆHrìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW+....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌ`HrÍª`DW+DàˆHrì......Phase 3A@..DWKDWÞ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1044 10441379104413791044.DWKB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWKDWÞ.DWK AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌ`HrÍª`DW+DàˆHrìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW+....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌ`HrÍª`DW+DàˆHrì......Phase 3A@..DWKDWÞ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1044 10441380104413801044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWG.DW¾DWG AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDä„HrÍÂ„DW¢DÞ0Hsˆñ0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDä„HrÍÂ„DW*DëŒHrêÊŒDWDÃðHsm'pDW¢DÞ0Hsˆñ0Phase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441380104413801044.DWGB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DW¾DWG AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDä„HrÍÂ„DW¢DÞ0Hsˆñ0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDä„HrÍÂ„DW*DëŒHrêÊŒDWDÃðHsm'pDW¢DÞ0Hsˆñ0Phase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441380104413801044DWDWBzREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DW¾DWG AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDä„HrÍÂ„DW¢DÞ0Hsˆñ0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDä„HrÍÂ„DW*DëŒHrêÊŒDWDÃðHsm'pDW¢DÞ0Hsˆñ0Phase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441380104413801044.DW¾B«OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DW¾DWGYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDä„HrÍÂ„DW¢DÞ0Hsˆñ0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDä„HrÍÂ„DW*DëŒHrêÊŒDWDÃðHsm'pDW¢DÞ0Hsˆñ0Phase 3A@..DWG.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441381104413811044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÆDWH AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDå°HrÍÃ°DWªDÑˆHs“pˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW‘DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDå°HrÍÃ°DW(D¥xHrçáxDW‘Dé¬Hsr“,DWªDÑˆHs“pˆPhase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1044 10441381104413811044.DWHB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÆDWH AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDå°HrÍÃ°DWªDÑˆHs“pˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW‘DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDå°HrÍÃ°DW(D¥xHrçáxDW‘Dé¬Hsr“,DWªDÑˆHs“pˆPhase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1044 10441381104413811044DW‘DW‘B~REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÆDWH AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDå°HrÍÃ°DWªDÑˆHs“pˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW‘DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDå°HrÍÃ°DW(D¥xHrçáxDW‘Dé¬Hsr“,DWªDÑˆHs“pˆPhase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1044 10441381104413811044.DWÆB³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWH.DWÆDWHYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDå°HrÍÃ°DWªDÑˆHs“pˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW‘DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDå°HrÍÃ°DW(D¥xHrçáxDW‘Dé¬Hsr“,DWªDÑˆHs“pˆPhase 3A@..DWH.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1044 10441382104413821044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWK.DW½DWK AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDùØHrÍ×ØDW¡DÛœHs‡Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDùØHrÍ×ØDW*DÖ8Hrêµ8DWDéèHsmMhDW¡DÛœHs‡Phase 3A@..DWK.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441382104413821044.DWKB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWK.DW½DWK AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDùØHrÍ×ØDW¡DÛœHs‡Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDùØHrÍ×ØDW*DÖ8Hrêµ8DWDéèHsmMhDW¡DÛœHs‡Phase 3A@..DWK.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441382104413821044DWDWBzREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWK.DW½DWK AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDùØHrÍ×ØDW¡DÛœHs‡Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDùØHrÍ×ØDW*DÖ8Hrêµ8DWDéèHsmMhDW¡DÛœHs‡Phase 3A@..DWK.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441382104413821044.DW½BªOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWK.DW½DWKYAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDùØHrÍ×ØDW¡DÛœHs‡Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW*.DWDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDùØHrÍ×ØDW*DÖ8Hrêµ8DWDéèHsmMhDW¡DÛœHs‡Phase 3A@..DWK.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1044 10441383104413831044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWKDWÚ.DWK AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDùœHrÍ×œDW*DÕüHrê´üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDùœHrÍ×œDW*DÕüHrê´ü......Phase 3A@..DWKDWÚ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1044 10441383104413831044.DWKB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWKDWÚ.DWK AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDùœHrÍ×œDW*DÕüHrê´üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDùœHrÍ×œDW*DÕüHrê´ü......Phase 3A@..DWKDWÚ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1044 10441384104413841044DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÃDWG AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDúÈHrÍØÈDW§DÜŒHs‡Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW+.DW”DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDúÈHrÍØÈDW+DílHrììDW”DØÌHsvvÌDW§DÜŒHs‡Phase 3A@..DWG.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1044 10441384104413841044.DWGB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÃDWG AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDúÈHrÍØÈDW§DÜŒHs‡Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW+.DW”DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDúÈHrÍØÈDW+DílHrììDW”DØÌHsvvÌDW§DÜŒHs‡Phase 3A@..DWG.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1044 10441384104413841044DW”DW”BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÃDWG AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDúÈHrÍØÈDW§DÜŒHs‡Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW+.DW”DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDúÈHrÍØÈDW+DílHrììDW”DØÌHsvvÌDW§DÜŒHs‡Phase 3A@..DWG.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1044 10441384104413841044.DWÃB°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÃDWGYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDúÈHrÍØÈDW§DÜŒHs‡Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW+.DW”DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDúÈHrÍØÈDW+DílHrììDW”DØÌHsvvÌDW§DÜŒHs‡Phase 3A@..DWG.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1057 10571376105713761057DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD•ÄHrýÄDWDÃ<HrÃ<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD•ÄHrýÄDWDÃ<HrÃ<......Phase 3A@..DW(DW»12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571376105713761057.DW(B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD•ÄHrýÄDWDÃ<HrÃ<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD•ÄHrýÄDWDÃ<HrÃ<......Phase 3A@..DW(DW»12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571377105713771057DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!..DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÑHrž9DWDøHr¹µxPlacebo Placebo 12-15 YearsA . . .DVðDW....DWPlacebo Placebo Placebo A .Placebo A .DVðDÑHrž9DWDøHr¹µx......Phase 3A@DWõ.DW!.12-15 YearsA YNN. DWŒDWõDWõAÐYEARSDSAC4591001C4591001 1057 10571377105713771057.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!..DW! AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÑHrž9DWDøHr¹µxPlacebo Placebo 12-15 YearsA . . .DVðDW....DWPlacebo Placebo Placebo A .Placebo A .DVðDÑHrž9DWDøHr¹µx......Phase 3A@DWõ.DW!.12-15 YearsA YNN. DWŒDWõDWõAÐYEARSDSA C4591001C4591001 1057 10571377105713771057.DWõC`FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BUNABLE TO DRIVE TO JACKSONVILLE FOR STUDY VISITS DW!..DW!YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDÑHrž9DWDøHr¹µxPlacebo Placebo 12-15 YearsA . . .DVðDW....DWPlacebo Placebo Placebo A .Placebo A .DVðDÑHrž9DWDøHr¹µx......Phase 3A@DWõ.DW!.12-15 YearsA YNN. DWŒDWõDWõAÐYEARSDSA`C4591001C4591001 1057 10571378105713781057DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!..DW! AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD×(Hrž?(DWDž¬Hr¹¶,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD×(Hrž?(DWDž¬Hr¹¶,......Phase 3A@DWõ.DW!.12-15 YearsAYYNY. DWŒDWõDWõAÀYEARSDSAC4591001C4591001 1057 10571378105713781057.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!..DW! AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD×(Hrž?(DWDž¬Hr¹¶,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD×(Hrž?(DWDž¬Hr¹¶,......Phase 3A@DWõ.DW!.12-15 YearsAYYNY. DWŒDWõDWõAÀYEARSDSA C4591001C4591001 1057 10571378105713781057.DWõC`FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BUNABLE TO DRIVE TO JACKSONVILLE FOR STUDY VISITS DW!..DW!YAÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD×(Hrž?(DWDž¬Hr¹¶,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD×(Hrž?(DWDž¬Hr¹¶,......Phase 3A@DWõ.DW!.12-15 YearsAYYNY. DWŒDWõDWõAÀYEARSDSA`C4591001C4591001 1057 10571379105713791057DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW¿DW$ AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDè¼HržP¼DW£D¢äHsŠdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDè¼HržP¼DWDïÄHr¼ªDDWDå8HsmH¸DW£D¢äHsŠdPhase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571379105713791057.DW$B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW¿DW$ AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDè¼HržP¼DW£D¢äHsŠdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDè¼HržP¼DWDïÄHr¼ªDDWDå8HsmH¸DW£D¢äHsŠdPhase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571379105713791057DWDWBžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW¿DW$ AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDè¼HržP¼DW£D¢äHsŠdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDè¼HržP¼DWDïÄHr¼ªDDWDå8HsmH¸DW£D¢äHsŠdPhase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1057 10571379105713791057.DW¿BÐOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DW¿DW$YAàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVðDè¼HržP¼DW£D¢äHsŠdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DWDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDè¼HržP¼DWDïÄHr¼ªDDWDå8HsmH¸DW£D¢äHsŠdPhase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1057 10571380105713801057DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÃ.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDŠ„HrŸDDWD~HrÂÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDŠ„HrŸDDWD~HrÂÐ......Phase 3A@..DW,DWÃ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571380105713801057.DW,B<VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÃ.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDŠ„HrŸDDWD~HrÂÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDŠ„HrŸDDWD~HrÂÐ......Phase 3A@..DW,DWÃ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571382105713821057DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDè€HrŸ¢DW D’ôHrÄ6tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDè€HrŸ¢DW D’ôHrÄ6t......Phase 3A@..DW)DW¼12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571382105713821057.DW)B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDè€HrŸ¢DW D’ôHrÄ6tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDè€HrŸ¢DW D’ôHrÄ6t......Phase 3A@..DW)DW¼12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571383105713831057DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDß˜HrŸ™DWªD¨ÀHs“GÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW‘DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDß˜HrŸ™DWDâàHr¼`DW‘Dã”HsrDWªD¨ÀHs“GÀPhase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571383105713831057.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDß˜HrŸ™DWªD¨ÀHs“GÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW‘DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDß˜HrŸ™DWDâàHr¼`DW‘Dã”HsrDWªD¨ÀHs“GÀPhase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571383105713831057DW‘DW‘B¡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDß˜HrŸ™DWªD¨ÀHs“GÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW‘DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDß˜HrŸ™DWDâàHr¼`DW‘Dã”HsrDWªD¨ÀHs“GÀPhase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1057 10571383105713831057.DWÍBÝOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÍDW$YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDß˜HrŸ™DWªD¨ÀHs“GÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW‘DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDß˜HrŸ™DWDâàHr¼`DW‘Dã”HsrDWªD¨ÀHs“GÀPhase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1057 10571384105713841057DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DWíDW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDæÜHrŸ \DWÑD–xHsÆŸøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¼DWÑ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDæÜHrŸ \DWD’@Hr¹©ÀDW¼DÄhHs«hDWÑD–xHsÆŸøPhase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1057 10571384105713841057.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWíDW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDæÜHrŸ \DWÑD–xHsÆŸøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¼DWÑ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDæÜHrŸ \DWD’@Hr¹©ÀDW¼DÄhHs«hDWÑD–xHsÆŸøPhase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1057 10571384105713841057DW¼DW¼BÌREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWíDW" AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDæÜHrŸ \DWÑD–xHsÆŸøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¼DWÑ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDæÜHrŸ \DWD’@Hr¹©ÀDW¼DÄhHs«hDWÑD–xHsÆŸøPhase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1057 10571384105713841057.DWíBýOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWíDW"YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDæÜHrŸ \DWÑD–xHsÆŸøPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW¼DWÑ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDæÜHrŸ \DWD’@Hr¹©ÀDW¼DÄhHs«hDWÑD–xHsÆŸøPhase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1057 10571385105713851057DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¿.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDëŒHrŸ¥DWDÎôHr¹ætBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW3BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDëŒHrŸ¥DWDÎôHr¹æt......Phase 3A@DWÓ.DW!DW¿12-15 YearsA YNY. DW2DWÓDWÓAðYEARSDSAC4591001C4591001 1057 10571385105713851057.DW!B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¿.DW! AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDëŒHrŸ¥DWDÎôHr¹ætBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW3BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDëŒHrŸ¥DWDÎôHr¹æt......Phase 3A@DWÓ.DW!DW¿12-15 YearsA YNY. DW2DWÓDWÓAðYEARSDSA C4591001C4591001 1057 10571385105713851057.DWÓBãFOLLOW-UP BDISPOSITION EVENTOTHER ApENROLLED INTO C4591031 DW!DW¿.DW!YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDëŒHrŸ¥DWDÎôHr¹ætBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW3BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDëŒHrŸ¥DWDÎôHr¹æt......Phase 3A@DWÓ.DW!DW¿12-15 YearsA YNY. DW2DWÓDWÓAðYEARSDSA@C4591001C4591001 1057 10571386105713861057DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVñDëPHrŸ¤ÐDWDß˜Hr»H˜Placebo Placebo 12-15 YearsA . . .DVñDW....DWPlacebo Placebo Placebo A .Placebo A .DVñDëPHrŸ¤ÐDWDß˜Hr»H˜......Phase 3A@..DW"DWµ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571386105713861057.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVñDëPHrŸ¤ÐDWDß˜Hr»H˜Placebo Placebo 12-15 YearsA . . .DVñDW....DWPlacebo Placebo Placebo A .Placebo A .DVñDëPHrŸ¤ÐDWDß˜Hr»H˜......Phase 3A@..DW"DWµ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571387105713871057DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÒDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÅ”Hr Ð”DW¶DãÐHs£TÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÅ”Hr Ð”DWDÁ\Hr¹ØÜDW¡DÚpHs‡›ðDW¶DãÐHs£TÐPhase 3A@..DW#.12-15 YearsA YNN. DW™DWýDWýAàYEARSDSAC4591001C4591001 1057 10571387105713871057.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÒDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÅ”Hr Ð”DW¶DãÐHs£TÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÅ”Hr Ð”DWDÁ\Hr¹ØÜDW¡DÚpHs‡›ðDW¶DãÐHs£TÐPhase 3A@..DW#.12-15 YearsA YNN. DW™DWýDWýAàYEARSDSA C4591001C4591001 1057 10571387105713871057DW¡DW¡B°REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÒDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÅ”Hr Ð”DW¶DãÐHs£TÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÅ”Hr Ð”DWDÁ\Hr¹ØÜDW¡DÚpHs‡›ðDW¶DãÐHs£TÐPhase 3A@..DW#.12-15 YearsA YNN. DW™DWýDWýAàYEARSDSA0C4591001C4591001 1057 10571387105713871057.DWÒBáOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÒDW#YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÅ”Hr Ð”DW¶DãÐHs£TÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW¡DW¶.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÅ”Hr Ð”DWDÁ\Hr¹ØÜDW¡DÚpHs‡›ðDW¶DãÐHs£TÐPhase 3A@..DW#.12-15 YearsA YNN. DW™DWýDWýAàYEARSDSA@C4591001C4591001 1057 10571388105713881057DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÉ.DW* AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÊHr ÕDWD™üHr¹±|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÊHr ÕDWD™üHr¹±|......Phase 3A@..DW*DWÉ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571388105713881057.DW*B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÉ.DW* AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÊHr ÕDWD™üHr¹±|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÊHr ÕDWD™üHr¹±|......Phase 3A@..DW*DWÉ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571389105713891057DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÉ.DW* AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDË4Hr Ö4DWDêØHrÃ<ØPlacebo Placebo 12-15 YearsA . . .DVòDW....DWPlacebo Placebo Placebo A .Placebo A .DVòDË4Hr Ö4DWDêØHrÃ<Ø......Phase 3A@..DW*DWÉ12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571389105713891057.DW*B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÉ.DW* AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDË4Hr Ö4DWDêØHrÃ<ØPlacebo Placebo 12-15 YearsA . . .DVòDW....DWPlacebo Placebo Placebo A .Placebo A .DVòDË4Hr Ö4DWDêØHrÃ<Ø......Phase 3A@..DW*DWÉ12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571390105713901057DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW·.DW$ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÏlHr ÚlDWDÐ˜Hr¹èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÏlHr ÚlDWDÐ˜Hr¹è......Phase 3A@DWÛ.DW$DW·12-15 YearsA YNY. DWDWÛDWÛAðYEARSDSAC4591001C4591001 1057 10571390105713901057.DW$B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW·.DW$ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÏlHr ÚlDWDÐ˜Hr¹èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÏlHr ÚlDWDÐ˜Hr¹è......Phase 3A@DWÛ.DW$DW·12-15 YearsA YNY. DWDWÛDWÛAðYEARSDSA C4591001C4591001 1057 10571390105713901057.DWÛBêFOLLOW-UP BDISPOSITION EVENTOTHER ApPARTICIPANT ENROLLED INTO C4591031 DW$DW·.DW$YAðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÏlHr ÚlDWDÐ˜Hr¹èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÏlHr ÚlDWDÐ˜Hr¹è......Phase 3A@DWÛ.DW$DW·12-15 YearsA YNY. DWDWÛDWÛAðYEARSDSA@C4591001C4591001 1057 10571391105713911057DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWpDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÐ˜Hr Û˜DWTDÝ@Hs"@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW?DWT.DW:Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÐ˜Hr Û˜DWDÑLHr¹èÌDW?DÙHsgˆDWTDÝ@Hs"@Phase 3A@..DW$.12-15 YearsA YNN. DW9DWýDWýAðYEARSDSAC4591001C4591001 1057 10571391105713911057.DW$B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWpDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÐ˜Hr Û˜DWTDÝ@Hs"@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW?DWT.DW:Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÐ˜Hr Û˜DWDÑLHr¹èÌDW?DÙHsgˆDWTDÝ@Hs"@Phase 3A@..DW$.12-15 YearsA YNN. DW9DWýDWýAðYEARSDSA C4591001C4591001 1057 10571391105713911057DW?DW?BNREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWpDW$ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÐ˜Hr Û˜DWTDÝ@Hs"@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW?DWT.DW:Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÐ˜Hr Û˜DWDÑLHr¹èÌDW?DÙHsgˆDWTDÝ@Hs"@Phase 3A@..DW$.12-15 YearsA YNN. DW9DWýDWýAðYEARSDSA0C4591001C4591001 1057 10571391105713911057.DWpBOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWpDW$YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÐ˜Hr Û˜DWTDÝ@Hs"@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW?DWT.DW:Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÐ˜Hr Û˜DWDÑLHr¹èÌDW?DÙHsgˆDWTDÝ@Hs"@Phase 3A@..DW$.12-15 YearsA YNN. DW9DWýDWýAðYEARSDSA@C4591001C4591001 1057 10571392105713921057DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDáHr ìDWDÅ”Hr¹ÝBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW3BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDáHr ìDWDÅ”Hr¹Ý......Phase 3A@DWÓ.DW#DW¶12-15 YearsA YNY. DW2DWÓDWÓAðYEARSDSAC4591001C4591001 1057 10571392105713921057.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDáHr ìDWDÅ”Hr¹ÝBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW3BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDáHr ìDWDÅ”Hr¹Ý......Phase 3A@DWÓ.DW#DW¶12-15 YearsA YNY. DW2DWÓDWÓAðYEARSDSA C4591001C4591001 1057 10571392105713921057.DWÓBâFOLLOW-UP BDISPOSITION EVENTOTHER ApENROLLED INTO C4591031 DW#DW¶.DW#YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDáHr ìDWDÅ”Hr¹ÝBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW3BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDáHr ìDWDÅ”Hr¹Ý......Phase 3A@DWÓ.DW#DW¶12-15 YearsA YNY. DW2DWÓDWÓAðYEARSDSA@C4591001C4591001 1057 10571393105713931057DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÊDW% AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDäHHr ïHDW®DãXHs˜ÈXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW›DW®.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDäHHr ïHDWDÆüHr¹Þ|DW›DÚ¬Hs³,DW®DãXHs˜ÈXPhase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1057 10571393105713931057.DW%B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÊDW% AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDäHHr ïHDW®DãXHs˜ÈXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW›DW®.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDäHHr ïHDWDÆüHr¹Þ|DW›DÚ¬Hs³,DW®DãXHs˜ÈXPhase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1057 10571393105713931057DW›DW›BªREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÊDW% AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDäHHr ïHDW®DãXHs˜ÈXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW›DW®.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDäHHr ïHDWDÆüHr¹Þ|DW›DÚ¬Hs³,DW®DãXHs˜ÈXPhase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1057 10571393105713931057.DWÊBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÊDW%YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDäHHr ïHDW®DãXHs˜ÈXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW›DW®.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDäHHr ïHDWDÆüHr¹Þ|DW›DÚ¬Hs³,DW®DãXHs˜ÈXPhase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1057 10571394105713941057DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDèDHr óDDW§Dß\Hs‰ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDèDHr óDDWDÅXHr».XDW‘DÝ¸Hsr‡8DW§Dß\Hs‰ÜPhase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1057 10571394105713941057.DW"B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDèDHr óDDW§Dß\Hs‰ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDèDHr óDDWDÅXHr».XDW‘DÝ¸Hsr‡8DW§Dß\Hs‰ÜPhase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1057 10571394105713941057DW‘DW‘B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW" AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDèDHr óDDW§Dß\Hs‰ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDèDHr óDDWDÅXHr».XDW‘DÝ¸Hsr‡8DW§Dß\Hs‰ÜPhase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1057 10571394105713941057.DWÅBÔOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW".DWÅDW"YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDèDHr óDDW§Dß\Hs‰ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDèDHr óDDWDÅXHr».XDW‘DÝ¸Hsr‡8DW§Dß\Hs‰ÜPhase 3A@..DW".12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1057 10571395105713951057DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8..DW8 AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDê$Hr õ$DWDäÀHrÐeÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDê$Hr õ$DWDäÀHrÐeÀ......Phase 3A@..DW8.12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571395105713951057.DW8BGVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8..DW8 AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDê$Hr õ$DWDäÀHrÐeÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDê$Hr õ$DWDäÀHrÐeÀ......Phase 3A@..DW8.12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571396105713961057DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW´.DW( AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÎ¸Hr¢+8DWDÆHr¹ÝŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÎ¸Hr¢+8DWDÆHr¹ÝŒ......Phase 3A@..DW(DW´12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571396105713961057.DW(B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW´.DW( AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÎ¸Hr¢+8DWDÆHr¹ÝŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÎ¸Hr¢+8DWDÆHr¹ÝŒ......Phase 3A@..DW(DW´12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571397105713971057DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDãXHr¢?ØDWDÛœHr¼–BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDãXHr¢?ØDWDÛœHr¼–......Phase 3A@..DW#DW¶12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571397105713971057.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDãXHr¢?ØDWDÛœHr¼–BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDãXHr¢?ØDWDÛœHr¼–......Phase 3A@..DW#DW¶12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571398105713981057DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¾DW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDäüHr¢A|DW¢DÄhHsˆ×hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDäüHr¢A|DWDÀ¨Hr¼{(DW‘DÁ\HsrjÜDW¢DÄhHsˆ×hPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571398105713981057.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¾DW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDäüHr¢A|DW¢DÄhHsˆ×hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDäüHr¢A|DWDÀ¨Hr¼{(DW‘DÁ\HsrjÜDW¢DÄhHsˆ×hPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571398105713981057DW‘DW‘BŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¾DW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDäüHr¢A|DW¢DÄhHsˆ×hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDäüHr¢A|DWDÀ¨Hr¼{(DW‘DÁ\HsrjÜDW¢DÄhHsˆ×hPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1057 10571398105713981057.DW¾BÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW¾DW#YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDäüHr¢A|DW¢DÄhHsˆ×hPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¢.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDäüHr¢A|DWDÀ¨Hr¼{(DW‘DÁ\HsrjÜDW¢DÄhHsˆ×hPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1057 10571399105713991057DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDé4Hr¢E´DWDÕHHr»>HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDé4Hr¢E´DWDÕHHr»>H......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571399105713991057.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDé4Hr¢E´DWDÕHHr»>HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDé4Hr¢E´DWDÕHHr»>H......Phase 3A@..DW#DW¶12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571400105714001057DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWàDW( AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD™„Hr£G„DW¦DÖìHsŽ/ìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD™„Hr£G„DWD{HHr¼5ÈDW‘DÄàHsrn`DW¦DÖìHsŽ/ìPhase 3A@..DW(.12-15 YearsAYYNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571400105714001057.DW(B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWàDW( AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD™„Hr£G„DW¦DÖìHsŽ/ìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD™„Hr£G„DWD{HHr¼5ÈDW‘DÄàHsrn`DW¦DÖìHsŽ/ìPhase 3A@..DW(.12-15 YearsAYYNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571400105714001057DW‘DW‘BžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWàDW( AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD™„Hr£G„DW¦DÖìHsŽ/ìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD™„Hr£G„DWD{HHr¼5ÈDW‘DÄàHsrn`DW¦DÖìHsŽ/ìPhase 3A@..DW(.12-15 YearsAYYNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1057 10571400105714001057.DWàBíOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWàDW(YAÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD™„Hr£G„DW¦DÖìHsŽ/ìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD™„Hr£G„DWD{HHr¼5ÈDW‘DÄàHsrn`DW¦DÖìHsŽ/ìPhase 3A@..DW(.12-15 YearsAYYNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1057 10571401105714011057DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW.DW$ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôD¬Hr£ZDWDÄhHr¼~èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôD¬Hr£ZDWDÄhHr¼~è......Phase 3A@..DW$DW12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571401105714011057.DW$B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW.DW$ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôD¬Hr£ZDWDÄhHr¼~èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôD¬Hr£ZDWDÄhHr¼~è......Phase 3A@..DW$DW12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571402105714021057DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWwDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DãÐHr§†PDW[DàLHs+XÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWFDW[.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DãÐHr§†PDWDÐ HrÅÅ DWFDædHs¯dDW[DàLHs+XÌPhase 3A@..DW*.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSAC4591001C4591001 1057 10571402105714021057.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWwDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DãÐHr§†PDW[DàLHs+XÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWFDW[.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DãÐHr§†PDWDÐ HrÅÅ DWFDædHs¯dDW[DàLHs+XÌPhase 3A@..DW*.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA C4591001C4591001 1057 10571402105714021057DWFDWFBPREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWwDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DãÐHr§†PDW[DàLHs+XÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWFDW[.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DãÐHr§†PDWDÐ HrÅÅ DWFDædHs¯dDW[DàLHs+XÌPhase 3A@..DW*.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA0C4591001C4591001 1057 10571402105714021057.DWwBOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWwDW*YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DãÐHr§†PDW[DàLHs+XÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWFDW[.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DãÐHr§†PDWDÐ HrÅÅ DWFDædHs¯dDW[DàLHs+XÌPhase 3A@..DW*.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA@C4591001C4591001 1057 10571403105714031057DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW».DW) AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dé¬Hr§Œ,DWDÄàHrÃàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dé¬Hr§Œ,DWDÄàHrÃà......Phase 3A@..DW)DW»12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571403105714031057.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW».DW) AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dé¬Hr§Œ,DWDÄàHrÃàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dé¬Hr§Œ,DWDÄàHrÃà......Phase 3A@..DW)DW»12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571404105714041057DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWïDW7 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŸØHr©åXDWÒDËèHsÈ&èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW»DWÒ.DW»Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŸØHr©åXDWDÕÀHrÃ'ÀDW»DÔ”Hs©ÝDWÒDËèHsÈ&èPhase 3A@..DW7.12-15 YearsA YNN. DWºDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571404105714041057.DW7B?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWïDW7 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŸØHr©åXDWÒDËèHsÈ&èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW»DWÒ.DW»Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŸØHr©åXDWDÕÀHrÃ'ÀDW»DÔ”Hs©ÝDWÒDËèHsÈ&èPhase 3A@..DW7.12-15 YearsA YNN. DWºDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571404105714041057DW»DW»BÃREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWïDW7 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŸØHr©åXDWÒDËèHsÈ&èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW»DWÒ.DW»Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŸØHr©åXDWDÕÀHrÃ'ÀDW»DÔ”Hs©ÝDWÒDËèHsÈ&èPhase 3A@..DW7.12-15 YearsA YNN. DWºDWýDWýAÐYEARSDSA0C4591001C4591001 1057 10571404105714041057.DWïB÷OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWïDW7YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŸØHr©åXDWÒDËèHsÈ&èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW»DWÒ.DW»Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŸØHr©åXDWDÕÀHrÃ'ÀDW»DÔ”Hs©ÝDWÒDËèHsÈ&èPhase 3A@..DW7.12-15 YearsA YNN. DWºDWýDWýAÐYEARSDSA@C4591001C4591001 1057 10571405105714051057DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¾.DW) AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDé4Hrª.´DW DáxHrÄ„øBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDé4Hrª.´DW DáxHrÄ„ø......Phase 3A@..DW)DW¾12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1057 10571405105714051057.DW)B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¾.DW) AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDé4Hrª.´DW DáxHrÄ„øBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDé4Hrª.´DW DáxHrÄ„ø......Phase 3A@..DW)DW¾12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1057 10571406105714061057DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÂDW) AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDê`Hrª/àDW¦DÃ<HsŽ<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDê`Hrª/àDW Dâ¤HrÄ†$DW‘Dâ,Hsr‹¬DW¦DÃ<HsŽ<Phase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571406105714061057.DW)B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÂDW) AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDê`Hrª/àDW¦DÃ<HsŽ<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDê`Hrª/àDW Dâ¤HrÄ†$DW‘Dâ,Hsr‹¬DW¦DÃ<HsŽ<Phase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571406105714061057DW‘DW‘B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÂDW) AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDê`Hrª/àDW¦DÃ<HsŽ<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDê`Hrª/àDW Dâ¤HrÄ†$DW‘Dâ,Hsr‹¬DW¦DÃ<HsŽ<Phase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1057 10571406105714061057.DWÂBÊOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÂDW)YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDê`Hrª/àDW¦DÃ<HsŽ<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDê`Hrª/àDW Dâ¤HrÄ†$DW‘Dâ,Hsr‹¬DW¦DÃ<HsŽ<Phase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1057 10571407105714071057DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DW€DW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDËèHr«bèDWdD—àHs6íàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWODWd.DW3Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDËèHr«bèDW Dß HrÄ‚ DWOD¨„HsODWdD—àHs6íàPhase 3A@..DW).12-15 YearsA YNN. DW2DWýDWýAðYEARSDSAC4591001C4591001 1057 10571407105714071057.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW€DW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDËèHr«bèDWdD—àHs6íàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWODWd.DW3Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDËèHr«bèDW Dß HrÄ‚ DWOD¨„HsODWdD—àHs6íàPhase 3A@..DW).12-15 YearsA YNN. DW2DWýDWýAðYEARSDSA C4591001C4591001 1057 10571407105714071057DWODWOBVREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW€DW) AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDËèHr«bèDWdD—àHs6íàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWODWd.DW3Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDËèHr«bèDW Dß HrÄ‚ DWOD¨„HsODWdD—àHs6íàPhase 3A@..DW).12-15 YearsA YNN. DW2DWýDWýAðYEARSDSA0C4591001C4591001 1057 10571407105714071057.DW€B‡OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DW€DW)YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDËèHr«bèDWdD—àHs6íàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DWODWd.DW3Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDËèHr«bèDW Dß HrÄ‚ DWOD¨„HsODWdD—àHs6íàPhase 3A@..DW).12-15 YearsA YNN. DW2DWýDWýAðYEARSDSA@C4591001C4591001 1057 10571408105714081057DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWËDW) AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÍÈHr«dÈDW¯DËèHsšhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW™DW¯.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÍÈHr«dÈDW Dß˜HrÄƒDW™DÝ@Hs}ÀDW¯DËèHsšhPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571408105714081057.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWËDW) AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÍÈHr«dÈDW¯DËèHsšhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW™DW¯.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÍÈHr«dÈDW Dß˜HrÄƒDW™DÝ@Hs}ÀDW¯DËèHsšhPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571408105714081057DW™DW™B REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWËDW) AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÍÈHr«dÈDW¯DËèHsšhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW™DW¯.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÍÈHr«dÈDW Dß˜HrÄƒDW™DÝ@Hs}ÀDW¯DËèHsšhPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1057 10571408105714081057.DWËBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWËDW)YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÍÈHr«dÈDW¯DËèHsšhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW™DW¯.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÍÈHr«dÈDW Dß˜HrÄƒDW™DÝ@Hs}ÀDW¯DËèHsšhPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1057 10571409105714091057DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÆüHr«]üDW DàˆHrÄ„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÆüHr«]üDW DàˆHrÄ„......Phase 3A@..DW)DW¼12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571409105714091057.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÆüHr«]üDW DàˆHrÄ„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÆüHr«]üDW DàˆHrÄ„......Phase 3A@..DW)DW¼12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571410105714101057DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW) AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDãXHr«zXDW¨DŠHHs†HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDãXHr«zXDW DÃHrÄf€DW“DÁ Hsu DW¨DŠHHs†HPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571410105714101057.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW) AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDãXHr«zXDW¨DŠHHs†HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDãXHr«zXDW DÃHrÄf€DW“DÁ Hsu DW¨DŠHHs†HPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571410105714101057DW“DW“BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW) AÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDãXHr«zXDW¨DŠHHs†HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDãXHr«zXDW DÃHrÄf€DW“DÁ Hsu DW¨DŠHHs†HPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1057 10571410105714101057.DWÄBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW)YAÀYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDãXHr«zXDW¨DŠHHs†HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDãXHr«zXDW DÃHrÄf€DW“DÁ Hsu DW¨DŠHHs†HPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1057 10571411105714111057DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¸.DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDêØHr«ØDWDŠÀHrÅÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDêØHr«ØDWDŠÀHrÅÀ......Phase 3A@..DW*DW¸12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1057 10571411105714111057.DW*B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¸.DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDêØHr«ØDWDŠÀHrÅÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDêØHr«ØDWDŠÀHrÅÀ......Phase 3A@..DW*DW¸12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1057 10571412105714121057DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÒ.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDëHr«‚DWDŠüHrÅüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDëHr«‚DWDŠüHrÅü......Phase 3A@..DW*DWÒ12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571412105714121057.DW*B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÒ.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDëHr«‚DWDŠüHrÅüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDëHr«‚DWDŠüHrÅü......Phase 3A@..DW*DWÒ12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571413105714131057DVþDVþ.SCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED ...DVþ AÐYEARSMAWHITE AWHITE AYNBNT162b2 Phase 2/3 (30 mcg)B2_P23_30Not Treated NOTTRT ......BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . ........ . .BNT162b2 Phase 2/3 (30 mcg)A€ .............Phase 3A@DVþDVþ..12-15 YearsA NN. DVþ.DVþAÐYEARSDSAC4591001C4591001 1057 10571413105714131057.DVþ.VACCINATION BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABDELAY CRITERIA MET ...DVþ AÐYEARSMAWHITE AWHITE AYNBNT162b2 Phase 2/3 (30 mcg)B2_P23_30Not Treated NOTTRT ......BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . ........ . .BNT162b2 Phase 2/3 (30 mcg)A€ .............Phase 3A@DVþDVþ..12-15 YearsA NN. DVþ.DVþAÐYEARSDSA0C4591001C4591001 1057 10571413105714131057.DVþ.FOLLOW-UP BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABDELAY CRITERIA MET ...DVþ AÐYEARSMAWHITE AWHITE AYNBNT162b2 Phase 2/3 (30 mcg)B2_P23_30Not Treated NOTTRT ......BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . ........ . .BNT162b2 Phase 2/3 (30 mcg)A€ .............Phase 3A@DVþDVþ..12-15 YearsA NN. DVþ.DVþAÐYEARSDSA@C4591001C4591001 1057 10571414105714141057DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVþD× Hr°´ DWDÜPHrÍºPPlacebo Placebo 12-15 YearsA . . .DVþDW.....Placebo Placebo Placebo A .Placebo A .DVþD× Hr°´ DWDÜPHrÍºP......Phase 3A@DW§.DW1.12-15 YearsA YNN. DW§.DW§AðYEARSDSAC4591001C4591001 1057 10571414105714141057.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVþD× Hr°´ DWDÜPHrÍºPPlacebo Placebo 12-15 YearsA . . .DVþDW.....Placebo Placebo Placebo A .Placebo A .DVþD× Hr°´ DWDÜPHrÍºP......Phase 3A@DW§.DW1.12-15 YearsA YNN. DW§.DW§AðYEARSDSA C4591001C4591001 1057 10571414105714141057.DW§BªFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT Bsubject no longer wants to participate DW1..DW1YAðYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVþD× Hr°´ DWDÜPHrÍºPPlacebo Placebo 12-15 YearsA . . .DVþDW.....Placebo Placebo Placebo A .Placebo A .DVþD× Hr°´ DWDÜPHrÍºP......Phase 3A@DW§.DW1.12-15 YearsA YNN. DW§.DW§AðYEARSDSAPC4591001C4591001 1057 10571415105714151057DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWO.DWâDWO AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDØHr°µDWÆD¨Hs¸1Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW¢DWÆ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDØHr°µDWDÜPHrÐ]PDW¢DÅXHsˆØXDWÆD¨Hs¸1Phase 3A@..DWO.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571415105714151057.DWOBRVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWO.DWâDWO AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDØHr°µDWÆD¨Hs¸1Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW¢DWÆ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDØHr°µDWDÜPHrÐ]PDW¢DÅXHsˆØXDWÆD¨Hs¸1Phase 3A@..DWO.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571415105714151057DW¢DW¢B¥REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWO.DWâDWO AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDØHr°µDWÆD¨Hs¸1Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW¢DWÆ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDØHr°µDWDÜPHrÐ]PDW¢DÅXHsˆØXDWÆD¨Hs¸1Phase 3A@..DWO.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1057 10571415105714151057.DWâBåOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWO.DWâDWOYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDØHr°µDWÆD¨Hs¸1Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW¢DWÆ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDØHr°µDWDÜPHrÐ]PDW¢DÅXHsˆØXDWÆD¨Hs¸1Phase 3A@..DWO.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1057 10571416105714161057DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWVDWÐ.DWV AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÙøHr°¶øDWDÞ¨HrÏ(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÙøHr°¶øDWDÞ¨HrÏ(......Phase 3A@..DWVDWÐ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571416105714161057.DWVBYVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWVDWÐ.DWV AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÙøHr°¶øDWDÞ¨HrÏ(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÙøHr°¶øDWDÞ¨HrÏ(......Phase 3A@..DWVDWÐ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571417105714171057DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÉDW7 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÛØHr°¸ØDWDÎ@Hs—aÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW‘DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÛØHr°¸ØDWDÝ|HrÌiüDW‘DÏlHsrxìDWDÎ@Hs—aÀPhase 3A@..DW7.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571417105714171057.DW7B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÉDW7 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÛØHr°¸ØDWDÎ@Hs—aÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW‘DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÛØHr°¸ØDWDÝ|HrÌiüDW‘DÏlHsrxìDWDÎ@Hs—aÀPhase 3A@..DW7.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571417105714171057DW‘DW‘B”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÉDW7 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÛØHr°¸ØDWDÎ@Hs—aÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW‘DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÛØHr°¸ØDWDÝ|HrÌiüDW‘DÏlHsrxìDWDÎ@Hs—aÀPhase 3A@..DW7.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1057 10571417105714171057.DWÉBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW7.DWÉDW7YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÛØHr°¸ØDWDÎ@Hs—aÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW‘DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÛØHr°¸ØDWDÝ|HrÌiüDW‘DÏlHsrxìDWDÎ@Hs—aÀPhase 3A@..DW7.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1057 10571418105714181057DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÙDHr²ÄDWDÊøHrÌWxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÙDHr²ÄDWDÊøHrÌWx......Phase 3A@DW÷.DW/.12-15 YearsA YNY. DWDW÷DW÷AàYEARSDSAC4591001C4591001 1057 10571418105714181057.DW/B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÙDHr²ÄDWDÊøHrÌWxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÙDHr²ÄDWDÊøHrÌWx......Phase 3A@DW÷.DW/.12-15 YearsA YNY. DWDW÷DW÷AàYEARSDSA C4591001C4591001 1057 10571418105714181057.DW÷BùFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN Bfather stated just didn't want daughter participating at this time. no other reason disclosed DW/..DW/YAàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÙDHr²ÄDWDÊøHrÌWxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÙDHr²ÄDWDÊøHrÌWx......Phase 3A@DW÷.DW/.12-15 YearsA YNY. DWDW÷DW÷AàYEARSDSA`C4591001C4591001 1057 10571419105714191057DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÛ$Hr² ¤DWD§HrÌ3œBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÛ$Hr² ¤DWD§HrÌ3œ......Phase 3A@..DW7.12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1057 10571419105714191057.DW7B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÛ$Hr² ¤DWD§HrÌ3œBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÛ$Hr² ¤DWD§HrÌ3œ......Phase 3A@..DW7.12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1057 10571420105714201057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED ...DW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¼Hr³¼DWD¥´HrÌ24Placebo Placebo 12-15 YearsA . . .DWDW.....Placebo Placebo Placebo A .Placebo A .DWD¼Hr³¼DWD¥´HrÌ24......Phase 3A@DW?DW?..12-15 YearsA YNN. DW?.DW?AàYEARSDSAC4591001C4591001 1057 10571420105714201057.DW?B@VACCINATION BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN Bmother stated she didn't want him to do it anymore ...DW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¼Hr³¼DWD¥´HrÌ24Placebo Placebo 12-15 YearsA . . .DWDW.....Placebo Placebo Placebo A .Placebo A .DWD¼Hr³¼DWD¥´HrÌ24......Phase 3A@DW?DW?..12-15 YearsA YNN. DW?.DW?AàYEARSDSA@C4591001C4591001 1057 10571420105714201057.DW?B@FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN Bmother stated she didn't want him to do it anymore ...DW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¼Hr³¼DWD¥´HrÌ24Placebo Placebo 12-15 YearsA . . .DWDW.....Placebo Placebo Placebo A .Placebo A .DWD¼Hr³¼DWD¥´HrÌ24......Phase 3A@DW?DW?..12-15 YearsA YNN. DW?.DW?AàYEARSDSAPC4591001C4591001 1057 10571421105714211057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDÍPHr³MPDWDÝ|HrÌiüPlacebo Placebo 12-15 YearsA . . .DWDW.....Placebo Placebo Placebo A .Placebo A .DWDÍPHr³MPDWDÝ|HrÌiü......Phase 3A@DWÆ.DW/.12-15 YearsA YNN. DWÆ.DWÆAðYEARSDSAC4591001C4591001 1057 10571421105714211057.DW/B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDÍPHr³MPDWDÝ|HrÌiüPlacebo Placebo 12-15 YearsA . . .DWDW.....Placebo Placebo Placebo A .Placebo A .DWDÍPHr³MPDWDÝ|HrÌiü......Phase 3A@DWÆ.DW/.12-15 YearsA YNN. DWÆ.DWÆAðYEARSDSA C4591001C4591001 1057 10571421105714211057.DWÆBÇFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BWITHDRAWAL BY PARENT/GUARDIAN DW/..DW/YAðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDÍPHr³MPDWDÝ|HrÌiüPlacebo Placebo 12-15 YearsA . . .DWDW.....Placebo Placebo Placebo A .Placebo A .DWDÍPHr³MPDWDÝ|HrÌiü......Phase 3A@DWÆ.DW/.12-15 YearsA YNN. DWÆ.DWÆAðYEARSDSAPC4591001C4591001 1057 10571422105714221057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÅ.DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÞ¨Hr³^¨DWDß HrÏ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÞ¨Hr³^¨DWDß HrÏ ......Phase 3A@..DW1DWÅ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1057 10571422105714221057.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÅ.DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÞ¨Hr³^¨DWDß HrÏ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÞ¨Hr³^¨DWDß HrÏ ......Phase 3A@..DW1DWÅ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1057 10571423105714231057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÉ.DW3 AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‰”Hr´[DWDŽDHrÑ`ÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‰”Hr´[DWDŽDHrÑ`Ä......Phase 3A@..DW3DWÉ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1057 10571423105714231057.DW3B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÉ.DW3 AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD‰”Hr´[DWDŽDHrÑ`ÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD‰”Hr´[DWDŽDHrÑ`Ä......Phase 3A@..DW3DWÉ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1057 10571424105714241057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÅDW3 AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDˆhHr´YèDW¨D‰Hs…Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDˆhHr´YèDWDpHrÑaðDW‘D«HsrT˜DW¨D‰Hs…Phase 3A@..DW3.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571424105714241057.DW3B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÅDW3 AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDˆhHr´YèDW¨D‰Hs…Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDˆhHr´YèDWDpHrÑaðDW‘D«HsrT˜DW¨D‰Hs…Phase 3A@..DW3.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571424105714241057DW‘DW‘B‘REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÅDW3 AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDˆhHr´YèDW¨D‰Hs…Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDˆhHr´YèDWDpHrÑaðDW‘D«HsrT˜DW¨D‰Hs…Phase 3A@..DW3.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1057 10571424105714241057.DWÅBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÅDW3YAÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDˆhHr´YèDW¨D‰Hs…Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDˆhHr´YèDWDpHrÑaðDW‘D«HsrT˜DW¨D‰Hs…Phase 3A@..DW3.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1057 10571425105714251057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœHr´nDWDÅHrÍ£Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWDœHr´nDWDÅHrÍ£......Phase 3A@DWÌ.DW7.12-15 YearsA YNN. DWŒDWÌDWÌAÐYEARSDSAC4591001C4591001 1057 10571425105714251057.DW7B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœHr´nDWDÅHrÍ£Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWDœHr´nDWDÅHrÍ£......Phase 3A@DWÌ.DW7.12-15 YearsA YNN. DWŒDWÌDWÌAÐYEARSDSA C4591001C4591001 1057 10571425105714251057.DWÌBÌFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BNO LONGER WISHES TO PARTICIPATE DW7..DW7YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœHr´nDWDÅHrÍ£Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWDœHr´nDWDÅHrÍ£......Phase 3A@DWÌ.DW7.12-15 YearsA YNN. DWŒDWÌDWÌAÐYEARSDSA`C4591001C4591001 1057 10571426105714261057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?..DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDžèHr´phDWDæ HrÙ¢ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDžèHr´phDWDæ HrÙ¢ ......Phase 3A@DWÞ.DW?.12-15 YearsA YNY. DWŒDWÞDWÞAÀYEARSDSAC4591001C4591001 1057 10571426105714261057.DW?B?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?..DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDžèHr´phDWDæ HrÙ¢ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDžèHr´phDWDæ HrÙ¢ ......Phase 3A@DWÞ.DW?.12-15 YearsA YNY. DWŒDWÞDWÞAÀYEARSDSA C4591001C4591001 1057 10571426105714261057.DWÞBÞFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BUNABLE TO COME IN FOR STUDY VISIT DW?..DW?YAÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDžèHr´phDWDæ HrÙ¢ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDžèHr´phDWDæ HrÙ¢ ......Phase 3A@DWÞ.DW?.12-15 YearsA YNY. DWŒDWÞDWÞAÀYEARSDSApC4591001C4591001 1057 10571427105714271057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD PHr´qÐDWDäüHrÙ |BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD PHr´qÐDWDäüHrÙ |......Phase 3A@..DW?DWÞ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571427105714271057.DW?B?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD PHr´qÐDWDäüHrÙ |BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD PHr´qÐDWDäüHrÙ |......Phase 3A@..DW?DWÞ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571428105714281057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¤Hr´uDWDæ HrÙ¢ Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWD¤Hr´uDWDæ HrÙ¢ ......Phase 3A@..DW?DWÞ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571428105714281057.DW?B?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¤Hr´uDWDæ HrÙ¢ Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWD¤Hr´uDWDæ HrÙ¢ ......Phase 3A@..DW?DWÞ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571429105714291057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¥Hr´v€DWDä„HrÙ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¥Hr´v€DWDä„HrÙ ......Phase 3A@..DW?DWÞ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1057 10571429105714291057.DW?B?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¥Hr´v€DWDä„HrÙ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¥Hr´v€DWDä„HrÙ ......Phase 3A@..DW?DWÞ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1057 10571430105714301057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÍŒHr»6ŒDWDÆHrÕBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÍŒHr»6ŒDWDÆHrÕ......Phase 3A@..DW6.12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571430105714301057.DW6B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÍŒHr»6ŒDWDÆHrÕBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÍŒHr»6ŒDWDÆHrÕ......Phase 3A@..DW6.12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571431105714311057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÊ¼Hr¼…<DW´D×ÜHs ¥ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW›DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÊ¼Hr¼…<DWDÃ´HrÕŠ´DW›DÝHsµ„DW´D×ÜHs ¥ÜPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571431105714311057.DW6B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÊ¼Hr¼…<DW´D×ÜHs ¥ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW›DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÊ¼Hr¼…<DWDÃ´HrÕŠ´DW›DÝHsµ„DW´D×ÜHs ¥ÜPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571431105714311057DW›DW›B•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÊ¼Hr¼…<DW´D×ÜHs ¥ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW›DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÊ¼Hr¼…<DWDÃ´HrÕŠ´DW›DÝHsµ„DW´D×ÜHs ¥ÜPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1057 10571431105714311057.DWÐBÊOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÐDW6YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÊ¼Hr¼…<DW´D×ÜHs ¥ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW›DW´.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÊ¼Hr¼…<DWDÃ´HrÕŠ´DW›DÝHsµ„DW´D×ÜHs ¥ÜPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1057 10571432105714321057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¼DW= AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÎHr¼ˆ„DW DÞ0Hs†N0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÎHr¼ˆ„DWDáxHrÕ¨xDWDÔHsm7œDW DÞ0Hs†N0Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571432105714321057.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¼DW= AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÎHr¼ˆ„DW DÞ0Hs†N0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÎHr¼ˆ„DWDáxHrÕ¨xDWDÔHsm7œDW DÞ0Hs†N0Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571432105714321057DWDWB‡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¼DW= AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÎHr¼ˆ„DW DÞ0Hs†N0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÎHr¼ˆ„DWDáxHrÕ¨xDWDÔHsm7œDW DÞ0Hs†N0Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1057 10571432105714321057.DW¼B¶OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DW¼DW=YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÎHr¼ˆ„DW DÞ0Hs†N0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWDW .DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÎHr¼ˆ„DWDáxHrÕ¨xDWDÔHsm7œDW DÞ0Hs†N0Phase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1057 10571433105714331057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:DWÍ.DW: AÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDçHr¼¢DWD{HrÚˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDçHr¼¢DWD{HrÚˆ......Phase 3A@..DW:DWÍ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571433105714331057.DW:B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:DWÍ.DW: AÀYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDçHr¼¢DWD{HrÚˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDçHr¼¢DWD{HrÚˆ......Phase 3A@..DW:DWÍ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571434105714341057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWØDW9 AÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DWDž4Hr½ª4DW¼D¦¤Hs«¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW©DW¼.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDž4Hr½ª4DWDÛ`HrÙ–àDW©D£˜Hs‘ñDW¼D¦¤Hs«¤Phase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571434105714341057.DW9B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWØDW9 AÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DWDž4Hr½ª4DW¼D¦¤Hs«¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW©DW¼.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDž4Hr½ª4DWDÛ`HrÙ–àDW©D£˜Hs‘ñDW¼D¦¤Hs«¤Phase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571434105714341057DW©DW©B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWØDW9 AÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DWDž4Hr½ª4DW¼D¦¤Hs«¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW©DW¼.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDž4Hr½ª4DWDÛ`HrÙ–àDW©D£˜Hs‘ñDW¼D¦¤Hs«¤Phase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1057 10571434105714341057.DWØBÑOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWØDW9YAÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DWDž4Hr½ª4DW¼D¦¤Hs«¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW©DW¼.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDž4Hr½ª4DWDÛ`HrÙ–àDW©D£˜Hs‘ñDW¼D¦¤Hs«¤Phase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1057 10571435105714351057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÒ.DW> AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌØHrÃØDW!D‡ðHrÞ‰pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWµBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌØHrÃØDW!D‡ðHrÞ‰p......Phase 3A@..DW>DWÒ12-15 YearsA YNY. DW´DWýDWýAÀYEARSDSAC4591001C4591001 1057 10571435105714351057.DW>B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÒ.DW> AÀYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌØHrÃØDW!D‡ðHrÞ‰pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWµBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌØHrÃØDW!D‡ðHrÞ‰p......Phase 3A@..DW>DWÒ12-15 YearsA YNY. DW´DWýDWýAÀYEARSDSA C4591001C4591001 1057 10571436105714361057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÒ.DW> AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDÍÈHrÃÈDWíDÞlHsëÑìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWÓDWí.DWµPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍÈHrÃÈDW!D‰ÐHrÞ‹PDWÓD’@HsÉ>ÀDWíDÞlHsëÑìPhase 3A@..DW>DWÒ12-15 YearsA YNN. DW´DWýDWýAàYEARSDSAC4591001C4591001 1057 10571436105714361057.DW>B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÒ.DW> AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDÍÈHrÃÈDWíDÞlHsëÑìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWÓDWí.DWµPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍÈHrÃÈDW!D‰ÐHrÞ‹PDWÓD’@HsÉ>ÀDWíDÞlHsëÑìPhase 3A@..DW>DWÒ12-15 YearsA YNN. DW´DWýDWýAàYEARSDSA C4591001C4591001 1057 10571436105714361057DWÓDWÓBÈREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÒ.DW> AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWDÍÈHrÃÈDWíDÞlHsëÑìPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWÓDWí.DWµPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÍÈHrÃÈDW!D‰ÐHrÞ‹PDWÓD’@HsÉ>ÀDWíDÞlHsëÑìPhase 3A@..DW>DWÒ12-15 YearsA YNN. DW´DWýDWýAàYEARSDSA0C4591001C4591001 1057 10571437105714371057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD..DWD AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDä„HrÃ6„DWæD™HHsâRHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWÑDWæ.DWÐPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDä„HrÃ6„DW!DÝ|HrÞÞüDWÑDÓ¤HsÆÝ$DWæD™HHsâRHPhase 3A@..DWD.12-15 YearsA YNN. DWÏDWýDWýAðYEARSDSAC4591001C4591001 1057 10571437105714371057.DWDB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD..DWD AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDä„HrÃ6„DWæD™HHsâRHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWÑDWæ.DWÐPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDä„HrÃ6„DW!DÝ|HrÞÞüDWÑDÓ¤HsÆÝ$DWæD™HHsâRHPhase 3A@..DWD.12-15 YearsA YNN. DWÏDWýDWýAðYEARSDSA C4591001C4591001 1057 10571437105714371057DWÑDWÑBÆREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD..DWD AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDä„HrÃ6„DWæD™HHsâRHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWÑDWæ.DWÐPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDä„HrÃ6„DW!DÝ|HrÞÞüDWÑDÓ¤HsÆÝ$DWæD™HHsâRHPhase 3A@..DWD.12-15 YearsA YNN. DWÏDWýDWýAðYEARSDSA0C4591001C4591001 1057 10571438105714381057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÑ.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDçHrÃ9DW!DÜŒHrÞÞBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWÐBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDçHrÃ9DW!DÜŒHrÞÞ......Phase 3A@..DWDDWÑ12-15 YearsA YNY. DWÏDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571438105714381057.DWDB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÑ.DWD AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDçHrÃ9DW!DÜŒHrÞÞBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DWÐBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDçHrÃ9DW!DÜŒHrÞÞ......Phase 3A@..DWDDWÑ12-15 YearsA YNY. DWÏDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571439105714391057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÂDWD AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈdHrÅ½dDW¦DÏ¨HsŽ(¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÈdHrÅ½dDW!DâàHrÞä`DW“DÒxHsuøDW¦DÏ¨HsŽ(¨Phase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571439105714391057.DWDB7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÂDWD AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈdHrÅ½dDW¦DÏ¨HsŽ(¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÈdHrÅ½dDW!DâàHrÞä`DW“DÒxHsuøDW¦DÏ¨HsŽ(¨Phase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571439105714391057DW“DW“B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÂDWD AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈdHrÅ½dDW¦DÏ¨HsŽ(¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÈdHrÅ½dDW!DâàHrÞä`DW“DÒxHsuøDW¦DÏ¨HsŽ(¨Phase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1057 10571439105714391057.DWÂBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÂDWDYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈdHrÅ½dDW¦DÏ¨HsŽ(¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DW“DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÈdHrÅ½dDW!DâàHrÞä`DW“DÒxHsuøDW¦DÏ¨HsŽ(¨Phase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1057 10571440105714401057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÐ.DW? AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDâhHrÅ×hDW#DÌœHráqBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDâhHrÅ×hDW#DÌœHráq......Phase 3A@..DW?DWÐ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571440105714401057.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÐ.DW? AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDâhHrÅ×hDW#DÌœHráqBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDâhHrÅ×hDW#DÌœHráq......Phase 3A@..DW?DWÐ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571441105714411057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDåìHrÅÚìDW¨DëŒHsçŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDåìHrÅÚìDW#DÙøHrá~xDW“DâhHsu.èDW¨DëŒHsçŒPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571441105714411057.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDåìHrÅÚìDW¨DëŒHsçŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDåìHrÅÚìDW#DÙøHrá~xDW“DâhHsu.èDW¨DëŒHsçŒPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571441105714411057DW“DW“B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDåìHrÅÚìDW¨DëŒHsçŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDåìHrÅÚìDW#DÙøHrá~xDW“DâhHsu.èDW¨DëŒHsçŒPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1057 10571441105714411057.DWÄB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW?YAÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDåìHrÅÚìDW¨DëŒHsçŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDåìHrÅÚìDW#DÙøHrá~xDW“DâhHsu.èDW¨DëŒHsçŒPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1057 10571442105714421057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWïDWE AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWD¡HrÆç„DWÓDHsÉ:Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWœDWÓ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡HrÆç„DW%D¥Hrãì€DWœD™üHs€ÃüDWÓDHsÉ:Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571442105714421057.DWEB7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWïDWE AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWD¡HrÆç„DWÓDHsÉ:Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWœDWÓ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡HrÆç„DW%D¥Hrãì€DWœD™üHs€ÃüDWÓDHsÉ:Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571442105714421057DWœDWœBŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWïDWE AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWD¡HrÆç„DWÓDHsÉ:Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWœDWÓ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡HrÆç„DW%D¥Hrãì€DWœD™üHs€ÃüDWÓDHsÉ:Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1057 10571442105714421057.DWïBáOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWïDWEYAÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWD¡HrÆç„DWÓDHsÉ:Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DWœDWÓ.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¡HrÆç„DW%D¥Hrãì€DWœD™üHs€ÃüDWÓDHsÉ:Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1057 10571443105714431057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWç.DW@ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŸœHrÈ7œDW$DÍÈHrâÃÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŸœHrÈ7œDW$DÍÈHrâÃÈ......Phase 3A@..DW@DWç12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571443105714431057.DW@B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWç.DW@ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŸœHrÈ7œDW$DÍÈHrâÃÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŸœHrÈ7œDW$DÍÈHrâÃÈ......Phase 3A@..DW@DWç12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571444105714441057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWç.DW@ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡@HrÈ9@DW$DÐ\HrâÆ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡@HrÈ9@DW$DÐ\HrâÆ\......Phase 3A@..DW@DWç12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1057 10571444105714441057.DW@B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWç.DW@ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡@HrÈ9@DW$DÐ\HrâÆ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡@HrÈ9@DW$DÐ\HrâÆ\......Phase 3A@..DW@DWç12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1057 10571445105714451057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWß.DWH AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœTHrÌ(ÔDW(D¨üHrçäüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DW|BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœTHrÌ(ÔDW(D¨üHrçäü......Phase 3A@..DWHDWß12-15 YearsA YNY. DW{DWýDWýAðYEARSDSAC4591001C4591001 1057 10571445105714451057.DWHB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWß.DWH AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœTHrÌ(ÔDW(D¨üHrçäüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DW|BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœTHrÌ(ÔDW(D¨üHrçäü......Phase 3A@..DWHDWß12-15 YearsA YNY. DW{DWýDWýAðYEARSDSA C4591001C4591001 1057 10571446105714461057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWG..DWG AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÊHrÌVˆDW(DàLHrèLPlacebo Placebo 12-15 YearsA . . .DWDW(.....Placebo Placebo Placebo A .Placebo A .DWDÊHrÌVˆDW(DàLHrèL......Phase 3A@DWü.DWG.12-15 YearsA YNN. DWü.DWüAÐYEARSDSAC4591001C4591001 1057 10571446105714461057.DWGB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWG..DWG AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÊHrÌVˆDW(DàLHrèLPlacebo Placebo 12-15 YearsA . . .DWDW(.....Placebo Placebo Placebo A .Placebo A .DWDÊHrÌVˆDW(DàLHrèL......Phase 3A@DWü.DWG.12-15 YearsA YNN. DWü.DWüAÐYEARSDSA C4591001C4591001 1057 10571446105714461057.DWüBêFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT Bno longer interested DWG..DWGYAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÊHrÌVˆDW(DàLHrèLPlacebo Placebo 12-15 YearsA . . .DWDW(.....Placebo Placebo Placebo A .Placebo A .DWDÊHrÌVˆDW(DàLHrèL......Phase 3A@DWü.DWG.12-15 YearsA YNN. DWü.DWüAÐYEARSDSAPC4591001C4591001 1057 10571447105714471057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÂDWF AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèøHrÌuxDW¦D} HsÖ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèøHrÌuxDW(DÞlHrèlDW’DÞ¨HssÙ¨DW¦D} HsÖ Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1057 10571447105714471057.DWFB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÂDWF AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèøHrÌuxDW¦D} HsÖ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèøHrÌuxDW(DÞlHrèlDW’DÞ¨HssÙ¨DW¦D} HsÖ Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1057 10571447105714471057DW’DW’B€REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÂDWF AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèøHrÌuxDW¦D} HsÖ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèøHrÌuxDW(DÞlHrèlDW’DÞ¨HssÙ¨DW¦D} HsÖ Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1057 10571447105714471057.DWÂB°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÂDWFYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDèøHrÌuxDW¦D} HsÖ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDèøHrÌuxDW(DÞlHrèlDW’DÞ¨HssÙ¨DW¦D} HsÖ Phase 3A@..DWF.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1057 10571448105714481057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDW×.DWF AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDëHrÌw”DW(DÞ¨Hrè¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDëHrÌw”DW(DÞ¨Hrè¨......Phase 3A@..DWFDW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571448105714481057.DWFB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDW×.DWF AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDëHrÌw”DW(DÞ¨Hrè¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW(....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDëHrÌw”DW(DÞ¨Hrè¨......Phase 3A@..DWFDW×12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571449105714491057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDøHrÍ{øDW§DÞ0Hsˆ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW”DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDøHrÍ{øDW)DÎ@Hré[ÀDW”Dß˜Hsv}˜DW§DÞ0Hsˆ°Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571449105714491057.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDøHrÍ{øDW§DÞ0Hsˆ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW”DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDøHrÍ{øDW)DÎ@Hré[ÀDW”Dß˜Hsv}˜DW§DÞ0Hsˆ°Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571449105714491057DW”DW”BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDøHrÍ{øDW§DÞ0Hsˆ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW”DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDøHrÍ{øDW)DÎ@Hré[ÀDW”Dß˜Hsv}˜DW§DÞ0Hsˆ°Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1057 10571449105714491057.DWÃB°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÃDWEYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDøHrÍ{øDW§DÞ0Hsˆ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW”DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDøHrÍ{øDW)DÎ@Hré[ÀDW”Dß˜Hsv}˜DW§DÞ0Hsˆ°Phase 3A@..DWE.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1057 10571450105714501057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE..DWE AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŸ`HrÍ}`DW)DÄ¤HréR$Placebo Placebo 12-15 YearsA . . .DWDW)....DWPlacebo Placebo Placebo A .Placebo A .DWDŸ`HrÍ}`DW)DÄ¤HréR$......Phase 3A@DWö.DWE.12-15 YearsA YNN. DWŒDWöDWöAÐYEARSDSAC4591001C4591001 1057 10571450105714501057.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE..DWE AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŸ`HrÍ}`DW)DÄ¤HréR$Placebo Placebo 12-15 YearsA . . .DWDW)....DWPlacebo Placebo Placebo A .Placebo A .DWDŸ`HrÍ}`DW)DÄ¤HréR$......Phase 3A@DWö.DWE.12-15 YearsA YNN. DWŒDWöDWöAÐYEARSDSA C4591001C4591001 1057 10571450105714501057.DWöBãFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT Bno longer interested in revax V101, no longer interested in study participation DWE..DWEYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDŸ`HrÍ}`DW)DÄ¤HréR$Placebo Placebo 12-15 YearsA . . .DWDW)....DWPlacebo Placebo Placebo A .Placebo A .DWDŸ`HrÍ}`DW)DÄ¤HréR$......Phase 3A@DWö.DWE.12-15 YearsA YNN. DWŒDWöDWöAÐYEARSDSApC4591001C4591001 1057 10571451105714511057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDË4HrÍ©4DW)DÆ„HréTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDË4HrÍ©4DW)DÆ„HréT......Phase 3A@..DWEDWØ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571451105714511057.DWEB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDË4HrÍ©4DW)DÆ„HréTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDË4HrÍ©4DW)DÆ„HréT......Phase 3A@..DWEDWØ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571452105714521057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWHDWÙ.DWH AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌ`HrÍª`DW*DÕHHrê´HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌ`HrÍª`DW*DÕHHrê´H......Phase 3A@..DWHDWÙ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1057 10571452105714521057.DWHB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWHDWÙ.DWH AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÌ`HrÍª`DW*DÕHHrê´HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÌ`HrÍª`DW*DÕHHrê´H......Phase 3A@..DWHDWÙ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1057 10571453105714531057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÂDWD AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáHrÍ¿DW¦D¿¸HsŽ¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáHrÍ¿DW(DÐÔHrèÔDW‘DàHsr‰DW¦D¿¸HsŽ¸Phase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571453105714531057.DWDB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÂDWD AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáHrÍ¿DW¦D¿¸HsŽ¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáHrÍ¿DW(DÐÔHrèÔDW‘DàHsr‰DW¦D¿¸HsŽ¸Phase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1057 10571453105714531057DW‘DW‘B~REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÂDWD AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáHrÍ¿DW¦D¿¸HsŽ¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáHrÍ¿DW(DÐÔHrèÔDW‘DàHsr‰DW¦D¿¸HsŽ¸Phase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1057 10571453105714531057.DWÂB¯OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÂDWDYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáHrÍ¿DW¦D¿¸HsŽ¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW(.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáHrÍ¿DW(DÐÔHrèÔDW‘DàHsr‰DW¦D¿¸HsŽ¸Phase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1057 10571454105714541057DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÞ.DWF AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDàˆHrÍ¾ˆDW*DÏlHrê®lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDàˆHrÍ¾ˆDW*DÏlHrê®l......Phase 3A@..DWFDWÞ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1057 10571454105714541057.DWFB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÞ.DWF AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDàˆHrÍ¾ˆDW*DÏlHrê®lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW*....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDàˆHrÍ¾ˆDW*DÏlHrê®l......Phase 3A@..DWFDWÞ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1066 10661394106613941066DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÌDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDž4Hr ©4DW®D¾Hs˜£Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDž4Hr ©4DWD¢äHr¼]dDW’Dv\Hssq\DW®D¾Hs˜£Phase 3A@..DW#.12-15 YearsAYYNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661394106613941066.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÌDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDž4Hr ©4DW®D¾Hs˜£Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDž4Hr ©4DWD¢äHr¼]dDW’Dv\Hssq\DW®D¾Hs˜£Phase 3A@..DW#.12-15 YearsAYYNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661394106613941066DW’DW’B¡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÌDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDž4Hr ©4DW®D¾Hs˜£Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDž4Hr ©4DWD¢äHr¼]dDW’Dv\Hssq\DW®D¾Hs˜£Phase 3A@..DW#.12-15 YearsAYYNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661394106613941066.DWÌBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÌDW#YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDž4Hr ©4DW®D¾Hs˜£Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDž4Hr ©4DWD¢äHr¼]dDW’Dv\Hssq\DW®D¾Hs˜£Phase 3A@..DW#.12-15 YearsAYYNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661395106613951066DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÍÈHr–LÈDVþD² Hr° BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVþ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÍÈHr–LÈDVþD² Hr° ......Phase 3A@..DWDW®12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1066 10661395106613951066.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVêDÍÈHr–LÈDVþD² Hr° BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVêDVþ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVêDÍÈHr–LÈDVþD² Hr° ......Phase 3A@..DWDW®12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1066 10661397106613971066DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDõdHr–tdDW¨D¦àHs¢àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDõdHr–tdDVÿDá<Hr²¼DW“D{„HstÈDW¨D¦àHs¢àPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661397106613971066.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDõdHr–tdDW¨D¦àHs¢àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDõdHr–tdDVÿDá<Hr²¼DW“D{„HstÈDW¨D¦àHs¢àPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661397106613971066DW“DW“BªREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDõdHr–tdDW¨D¦àHs¢àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDõdHr–tdDVÿDá<Hr²¼DW“D{„HstÈDW¨D¦àHs¢àPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661397106613971066.DWÄBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDWYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDõdHr–tdDW¨D¦àHs¢àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDõdHr–tdDVÿDá<Hr²¼DW“D{„HstÈDW¨D¦àHs¢àPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661401106614011066DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÅDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÒðHr—£pDW¦DxxHsÑxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÒðHr—£pDVþDÎ¸Hr°«¸DW“DÝ|Hsu)üDW¦DxxHsÑxPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661401106614011066.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÅDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÒðHr—£pDW¦DxxHsÑxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÒðHr—£pDVþDÎ¸Hr°«¸DW“DÝ|Hsu)üDW¦DxxHsÑxPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661401106614011066DW“DW“B©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÅDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÒðHr—£pDW¦DxxHsÑxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÒðHr—£pDVþDÎ¸Hr°«¸DW“DÝ|Hsu)üDW¦DxxHsÑxPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661401106614011066.DWÅBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÅDWYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDÒðHr—£pDW¦DxxHsÑxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDÒðHr—£pDVþDÎ¸Hr°«¸DW“DÝ|Hsu)üDW¦DxxHsÑxPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661402106614021066DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDÞ¨Hr—¯(DVþDÞ¨Hr°»¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDÞ¨Hr—¯(DVþDÞ¨Hr°»¨......Phase 3A@..DWDW°12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661402106614021066.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDÞ¨Hr—¯(DVþDÞ¨Hr°»¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDÞ¨Hr—¯(DVþDÞ¨Hr°»¨......Phase 3A@..DWDW°12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661403106614031066DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÄDW$ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD¤LHr˜ÆLDW¨D„äHs€äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìD¤LHr˜ÆLDWD–<Hr³<DW’D®`Hss©`DW¨D„äHs€äPhase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661403106614031066.DW$B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÄDW$ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD¤LHr˜ÆLDW¨D„äHs€äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìD¤LHr˜ÆLDWD–<Hr³<DW’D®`Hss©`DW¨D„äHs€äPhase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661403106614031066DW’DW’B§REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÄDW$ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD¤LHr˜ÆLDW¨D„äHs€äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìD¤LHr˜ÆLDWD–<Hr³<DW’D®`Hss©`DW¨D„äHs€äPhase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661403106614031066.DWÄBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÄDW$YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD¤LHr˜ÆLDW¨D„äHs€äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìD¤LHr˜ÆLDWD–<Hr³<DW’D®`Hss©`DW¨D„äHs€äPhase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661404106614041066DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¯.DW$ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìD¤Hr˜ÆDWD–xHr³xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìD¤Hr˜ÆDWD–xHr³x......Phase 3A@..DW$DW¯12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1066 10661404106614041066.DW$B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¯.DW$ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìD¤Hr˜ÆDWD–xHr³xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìD¤Hr˜ÆDWD–xHr³x......Phase 3A@..DW$DW¯12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1066 10661405106614051066DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÂDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDå8Hr™8DW¦DÍŒHsŽ&ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW’DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDå8Hr™8DVÿD§”Hr±ÖDW’DÈ(HssÃ(DW¦DÍŒHsŽ&ŒPhase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1066 10661405106614051066.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÂDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDå8Hr™8DW¦DÍŒHsŽ&ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW’DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDå8Hr™8DVÿD§”Hr±ÖDW’DÈ(HssÃ(DW¦DÍŒHsŽ&ŒPhase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1066 10661405106614051066DW’DW’B§REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÂDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDå8Hr™8DW¦DÍŒHsŽ&ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW’DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDå8Hr™8DVÿD§”Hr±ÖDW’DÈ(HssÃ(DW¦DÍŒHsŽ&ŒPhase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1066 10661405106614051066.DWÂB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÂDWYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDå8Hr™8DW¦DÍŒHsŽ&ŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW’DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDå8Hr™8DVÿD§”Hr±ÖDW’DÈ(HssÃ(DW¦DÍŒHsŽ&ŒPhase 3A@..DW.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1066 10661407106614071066DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD˜XHršØDVÿD€èHr±¯hBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDVÿ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD˜XHršØDVÿD€èHr±¯h......Phase 3A@..DWDW°12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1066 10661407106614071066.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD˜XHršØDVÿD€èHr±¯hBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDVÿ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD˜XHršØDVÿD€èHr±¯h......Phase 3A@..DWDW°12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1066 10661408106614081066DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDè¼HrŸ¢<DWDÂˆHr¹ÚBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW2BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDè¼HrŸ¢<DWDÂˆHr¹Ú......Phase 3A@DWÞ.DW"DWµ12-15 YearsAYYNY. DW1DWÞDWÞAðYEARSDSAC4591001C4591001 1066 10661408106614081066.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDè¼HrŸ¢<DWDÂˆHr¹ÚBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW2BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDè¼HrŸ¢<DWDÂˆHr¹Ú......Phase 3A@DWÞ.DW"DWµ12-15 YearsAYYNY. DW1DWÞDWÞAðYEARSDSA C4591001C4591001 1066 10661408106614081066.DWÞBîFOLLOW-UP BDISPOSITION EVENTOTHER ApSubject enrolled in C4591031 DW"DWµ.DW"YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDè¼HrŸ¢<DWDÂˆHr¹ÚBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW2BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDè¼HrŸ¢<DWDÂˆHr¹Ú......Phase 3A@DWÞ.DW"DWµ12-15 YearsAYYNY. DW1DWÞDWÞAðYEARSDSA@C4591001C4591001 1066 10661409106614091066DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDé4HrŸ¢´DWDÂÄHr¹ÚDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDé4HrŸ¢´DWDÂÄHr¹ÚD......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1066 10661409106614091066.DW"B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDé4HrŸ¢´DWDÂÄHr¹ÚDBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDé4HrŸ¢´DWDÂÄHr¹ÚD......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1066 10661410106614101066DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÂˆHr ÍˆDW§D¬HsX,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÂˆHr ÍˆDWDÚèHr»CèDW’Dµ¤Hss°¤DW§D¬HsX,Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1066 10661410106614101066.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÂˆHr ÍˆDW§D¬HsX,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÂˆHr ÍˆDWDÚèHr»CèDW’Dµ¤Hss°¤DW§D¬HsX,Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1066 10661410106614101066DW’DW’B¡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÂˆHr ÍˆDW§D¬HsX,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÂˆHr ÍˆDWDÚèHr»CèDW’Dµ¤Hss°¤DW§D¬HsX,Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1066 10661410106614101066.DWÅBÔOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÅDW#YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÂˆHr ÍˆDW§D¬HsX,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDÂˆHr ÍˆDWDÚèHr»CèDW’Dµ¤Hss°¤DW§D¬HsX,Phase 3A@..DW#.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1066 10661411106614111066DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¶.DW$ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDìHr ÷DWDÀlHr»)lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW2BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDìHr ÷DWDÀlHr»)l......Phase 3A@..DW$DW¶12-15 YearsA YNY. DW1DWýDWýAðYEARSDSAC4591001C4591001 1066 10661411106614111066.DW$B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW¶.DW$ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDìHr ÷DWDÀlHr»)lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW2BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDìHr ÷DWDÀlHr»)l......Phase 3A@..DW$DW¶12-15 YearsA YNY. DW1DWýDWýAðYEARSDSA C4591001C4591001 1066 10661412106614121066DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÑDW$ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDëŒHr öŒDW¨DÇtHsÃtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDëŒHr öŒDWDÀ0Hr»)0DW’Dn(Hssi(DW¨DÇtHsÃtPhase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661412106614121066.DW$B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÑDW$ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDëŒHr öŒDW¨DÇtHsÃtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDëŒHr öŒDWDÀ0Hr»)0DW’Dn(Hssi(DW¨DÇtHsÃtPhase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661412106614121066DW’DW’B¡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÑDW$ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDëŒHr öŒDW¨DÇtHsÃtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDëŒHr öŒDWDÀ0Hr»)0DW’Dn(Hssi(DW¨DÇtHsÃtPhase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661412106614121066.DWÑBàOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÑDW$YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDëŒHr öŒDW¨DÇtHsÃtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòDëŒHr öŒDWDÀ0Hr»)0DW’Dn(Hssi(DW¨DÇtHsÃtPhase 3A@..DW$.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661414106614141066DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÞ¨Hr§(DWD©°HrÂû°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW»BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÞ¨Hr§(DWD©°HrÂû°......Phase 3A@..DW(DW»12-15 YearsA YNY. DWºDWýDWýAðYEARSDSAC4591001C4591001 1066 10661414106614141066.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW».DW( AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÞ¨Hr§(DWD©°HrÂû°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW»BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÞ¨Hr§(DWD©°HrÂû°......Phase 3A@..DW(DW»12-15 YearsA YNY. DWºDWýDWýAðYEARSDSA C4591001C4591001 1066 10661415106614151066DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW»DWóDW( AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÜÈHr§HDW×D•ˆHsÎˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWÂDW×.DW»Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÜÈHr§HDWD©tHrÂûtDWÂD‘PHs²ÔPDW×D•ˆHsÎˆPhase 3A@..DW(DW»12-15 YearsA YNN. DWºDWýDWýAàYEARSDSAC4591001C4591001 1066 10661415106614151066.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW»DWóDW( AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÜÈHr§HDW×D•ˆHsÎˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWÂDW×.DW»Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÜÈHr§HDWD©tHrÂûtDWÂD‘PHs²ÔPDW×D•ˆHsÎˆPhase 3A@..DW(DW»12-15 YearsA YNN. DWºDWýDWýAàYEARSDSA C4591001C4591001 1066 10661415106614151066DWÂDWÂBÌREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW»DWóDW( AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÜÈHr§HDW×D•ˆHsÎˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWÂDW×.DW»Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÜÈHr§HDWD©tHrÂûtDWÂD‘PHs²ÔPDW×D•ˆHsÎˆPhase 3A@..DW(DW»12-15 YearsA YNN. DWºDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661415106614151066.DWóBýOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW»DWóDW(YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÜÈHr§HDW×D•ˆHsÎˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWÂDW×.DW»Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÜÈHr§HDWD©tHrÂûtDWÂD‘PHs²ÔPDW×D•ˆHsÎˆPhase 3A@..DW(DW»12-15 YearsA YNN. DWºDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661416106614161066DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWËDW) AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDæÜHr¨ÚÜDW¯Dƒ¸Hs™º8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW™DW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDæÜHr¨ÚÜDW DÙøHrÄ}xDW™DÙDHs}ÄDW¯Dƒ¸Hs™º8Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1066 10661416106614161066.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWËDW) AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDæÜHr¨ÚÜDW¯Dƒ¸Hs™º8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW™DW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDæÜHr¨ÚÜDW DÙøHrÄ}xDW™DÙDHs}ÄDW¯Dƒ¸Hs™º8Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1066 10661416106614161066DW™DW™B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWËDW) AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDæÜHr¨ÚÜDW¯Dƒ¸Hs™º8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW™DW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDæÜHr¨ÚÜDW DÙøHrÄ}xDW™DÙDHs}ÄDW¯Dƒ¸Hs™º8Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1066 10661416106614161066.DWËBÔOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWËDW)YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDæÜHr¨ÚÜDW¯Dƒ¸Hs™º8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW™DW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDæÜHr¨ÚÜDW DÙøHrÄ}xDW™DÙDHs}ÄDW¯Dƒ¸Hs™º8Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1066 10661417106614171066DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWî.DW1 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÑÄHrªDDWD× HrÅÌ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÑÄHrªDDWD× HrÅÌ ......Phase 3A@..DW1DWî12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1066 10661417106614171066.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWî.DW1 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÑÄHrªDDWD× HrÅÌ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÑÄHrªDDWD× HrÅÌ ......Phase 3A@..DW1DWî12-15 YearsAYYNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1066 10661418106614181066DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÑDW) AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÖìHrªlDW°D…\Hs› \Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW”DW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÖìHrªlDW D× HrÄ{ DW”DÉHsvgDW°D…\Hs› \Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661418106614181066.DW)B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÑDW) AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÖìHrªlDW°D…\Hs› \Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW”DW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÖìHrªlDW D× HrÄ{ DW”DÉHsvgDW°D…\Hs› \Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661418106614181066DW”DW”BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÑDW) AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÖìHrªlDW°D…\Hs› \Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW”DW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÖìHrªlDW D× HrÄ{ DW”DÉHsvgDW°D…\Hs› \Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661418106614181066.DWÑBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÑDW)YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÖìHrªlDW°D…\Hs› \Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW”DW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÖìHrªlDW D× HrÄ{ DW”DÉHsvgDW°D…\Hs› \Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661419106614191066DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÐ.DW* AàYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDáHrª&€DWDÂˆHrÅ·ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDáHrª&€DWDÂˆHrÅ·ˆ......Phase 3A@..DW*DWÐ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661419106614191066.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÐ.DW* AàYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDáHrª&€DWDÂˆHrÅ·ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDáHrª&€DWDÂˆHrÅ·ˆ......Phase 3A@..DW*DWÐ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661420106614201066DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*..DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÙ€Hr«p€DW DáHrÄ„€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DWKBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÙ€Hr«p€DW DáHrÄ„€......Phase 3A@..DW*.12-15 YearsAYYNY. DWJDWýDWýAðYEARSDSAC4591001C4591001 1066 10661420106614201066.DW*B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*..DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÙ€Hr«p€DW DáHrÄ„€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DWKBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÙ€Hr«p€DW DáHrÄ„€......Phase 3A@..DW*.12-15 YearsAYYNY. DWJDWýDWýAðYEARSDSA C4591001C4591001 1066 10661421106614211066DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÌDW2 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD”ÔHr±ÃTDW°DœHs›œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD”ÔHr±ÃTDWDHrÎ½DW“D¨ÀHstõ@DW°DœHs›œPhase 3A@..DW2.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661421106614211066.DW2B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÌDW2 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD”ÔHr±ÃTDW°DœHs›œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD”ÔHr±ÃTDWDHrÎ½DW“D¨ÀHstõ@DW°DœHs›œPhase 3A@..DW2.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661421106614211066DW“DW“B•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÌDW2 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD”ÔHr±ÃTDW°DœHs›œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD”ÔHr±ÃTDWDHrÎ½DW“D¨ÀHstõ@DW°DœHs›œPhase 3A@..DW2.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661421106614211066.DWÌBÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÌDW2YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD”ÔHr±ÃTDW°DœHs›œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW“DW°.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD”ÔHr±ÃTDWDHrÎ½DW“D¨ÀHstõ@DW°DœHs›œPhase 3A@..DW2.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661422106614221066DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DWÅ.DW2 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD•LHr±ÃÌDWDTHrÎ¼ÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD•LHr±ÃÌDWDTHrÎ¼Ô......Phase 3A@..DW2DWÅ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1066 10661422106614221066.DW2B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DWÅ.DW2 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD•LHr±ÃÌDWDTHrÎ¼ÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD•LHr±ÃÌDWDTHrÎ¼Ô......Phase 3A@..DW2DWÅ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1066 10661423106614231066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDu0Hr¼/°DWD®œHs—BPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDu0Hr¼/°DW"D{HHrßÎHDW“DÔÐHsu!PDWD®œHs—BPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1066 10661423106614231066.DW>B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDu0Hr¼/°DWD®œHs—BPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDu0Hr¼/°DW"D{HHrßÎHDW“DÔÐHsu!PDWD®œHs—BPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1066 10661423106614231066DW“DW“BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW> AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDu0Hr¼/°DWD®œHs—BPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDu0Hr¼/°DW"D{HHrßÎHDW“DÔÐHsu!PDWD®œHs—BPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1066 10661423106614231066.DWÉBÃOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÉDW>YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDu0Hr¼/°DWD®œHs—BPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDu0Hr¼/°DW"D{HHrßÎHDW“DÔÐHsu!PDWD®œHs—BPhase 3A@..DW>.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1066 10661424106614241066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÙ.DW? AàYEARSMANATIVE HAWAIIAN OR OTHER PACIFIC ISLANDERAPNATIVE HAWAIIAN OR OTHER PACIFIC ISLANDERAPYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDØHr¼KXDWD£ HrØ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDØHr¼KXDWD£ HrØ ......Phase 3A@..DW?DWÙ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661424106614241066.DW?B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÙ.DW? AàYEARSMANATIVE HAWAIIAN OR OTHER PACIFIC ISLANDERAPNATIVE HAWAIIAN OR OTHER PACIFIC ISLANDERAPYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDØHr¼KXDWD£ HrØ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDØHr¼KXDWD£ HrØ ......Phase 3A@..DW?DWÙ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661425106614251066DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÅDWE AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dá<HrÄ„¼DW§D”ÔHs?TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW”DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dá<HrÄ„¼DW"DÏäHrà"äDW”Dx´Hsv´DW§D”ÔHs?TPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661425106614251066.DWEB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÅDWE AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dá<HrÄ„¼DW§D”ÔHs?TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW”DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dá<HrÄ„¼DW"DÏäHrà"äDW”Dx´Hsv´DW§D”ÔHs?TPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661425106614251066DW”DW”BˆREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÅDWE AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dá<HrÄ„¼DW§D”ÔHs?TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW”DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dá<HrÄ„¼DW"DÏäHrà"äDW”Dx´Hsv´DW§D”ÔHs?TPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661425106614251066.DWÅB¹OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÅDWEYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dá<HrÄ„¼DW§D”ÔHs?TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW”DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dá<HrÄ„¼DW"DÏäHrà"äDW”Dx´Hsv´DW§D”ÔHs?TPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661426106614261066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÂDWG AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DWD›ÜHrÅÜDW¦D‚ÈHsÛÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD›ÜHrÅÜDW$D’|Hrâˆ|DW“D˜XHstäØDW¦D‚ÈHsÛÈPhase 3A@..DWG.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1066 10661426106614261066.DWGB:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÂDWG AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DWD›ÜHrÅÜDW¦D‚ÈHsÛÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD›ÜHrÅÜDW$D’|Hrâˆ|DW“D˜XHstäØDW¦D‚ÈHsÛÈPhase 3A@..DWG.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1066 10661426106614261066DW“DW“B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÂDWG AðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DWD›ÜHrÅÜDW¦D‚ÈHsÛÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD›ÜHrÅÜDW$D’|Hrâˆ|DW“D˜XHstäØDW¦D‚ÈHsÛÈPhase 3A@..DWG.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1066 10661426106614261066.DWÂBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWG.DWÂDWGYAðYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DWD›ÜHrÅÜDW¦D‚ÈHsÛÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW$.DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD›ÜHrÅÜDW$D’|Hrâˆ|DW“D˜XHstäØDW¦D‚ÈHsÛÈPhase 3A@..DWG.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1066 10661427106614271066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÒ.DWF AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœHrÅ‘DW#D’@Hrá6ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœHrÅ‘DW#D’@Hrá6À......Phase 3A@..DWFDWÒ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1066 10661427106614271066.DWFB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÒ.DWF AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœHrÅ‘DW#D’@Hrá6ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœHrÅ‘DW#D’@Hrá6À......Phase 3A@..DWFDWÒ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1066 10661428106614281066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED ..DWƒDWL AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWD¶ÐHrÅ«ÐDWgD¹dHs;äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWRDWg.DW2Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¶ÐHrÅ«ÐDW"DÔ”Hrà'”DWRDÛ$Hsv$DWgD¹dHs;äPhase 3A@.DW2..12-15 YearsA YNN. DW1DWýDWýAðYEARSDSAC4591001C4591001 1066 10661428106614281066DWRDWRBEREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED ..DWƒDWL AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWD¶ÐHrÅ«ÐDWgD¹dHs;äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWRDWg.DW2Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¶ÐHrÅ«ÐDW"DÔ”Hrà'”DWRDÛ$Hsv$DWgD¹dHs;äPhase 3A@.DW2..12-15 YearsA YNN. DW1DWýDWýAðYEARSDSA C4591001C4591001 1066 10661428106614281066.DWƒBvOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED ..DWƒDWLYAðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWD¶ÐHrÅ«ÐDWgD¹dHs;äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWRDWg.DW2Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¶ÐHrÅ«ÐDW"DÔ”Hrà'”DWRDÛ$Hsv$DWgD¹dHs;äPhase 3A@.DW2..12-15 YearsA YNN. DW1DWýDWýAðYEARSDSA0C4591001C4591001 1066 10661428106614281066.DW2B%VACCINATION BDISPOSITION EVENTOTHER Apsubject unblinded for vax 3 per protocol ..DWƒDWL AðYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DWD¶ÐHrÅ«ÐDWgD¹dHs;äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DWRDWg.DW2Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¶ÐHrÅ«ÐDW"DÔ”Hrà'”DWRDÛ$Hsv$DWgD¹dHs;äPhase 3A@.DW2..12-15 YearsA YNN. DW1DWýDWýAðYEARSDSA`C4591001C4591001 1066 10661429106614291066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÞ¨HrÅÓ¨DWìDÚ¬Hsê|¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW×DWì.DWÒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÞ¨HrÅÓ¨DW#DÜPHrá€ÐDW×D”ÔHsÎ‡TDWìDÚ¬Hsê|¬Phase 3A@..DWF.12-15 YearsA YNN. DWÑDWýDWýAÀYEARSDSAC4591001C4591001 1066 10661429106614291066.DWFB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÞ¨HrÅÓ¨DWìDÚ¬Hsê|¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW×DWì.DWÒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÞ¨HrÅÓ¨DW#DÜPHrá€ÐDW×D”ÔHsÎ‡TDWìDÚ¬Hsê|¬Phase 3A@..DWF.12-15 YearsA YNN. DWÑDWýDWýAÀYEARSDSA C4591001C4591001 1066 10661429106614291066DW×DW×BÊREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÞ¨HrÅÓ¨DWìDÚ¬Hsê|¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW×DWì.DWÒPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÞ¨HrÅÓ¨DW#DÜPHrá€ÐDW×D”ÔHsÎ‡TDWìDÚ¬Hsê|¬Phase 3A@..DWF.12-15 YearsA YNN. DWÑDWýDWýAÀYEARSDSA0C4591001C4591001 1066 10661430106614301066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDp€HrÆ·DW"Dg Hrßº BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDp€HrÆ·DW"Dg Hrßº ......Phase 3A@..DWEDWØ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1066 10661430106614301066.DWEB7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWEDWØ.DWE AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDp€HrÆ·DW"Dg Hrßº BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW"....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDp€HrÆ·DW"Dg Hrßº ......Phase 3A@..DWEDWØ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1066 10661431106614311066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD©ìHrÆðlDW#DoÌHráLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD©ìHrÆðlDW#DoÌHráL......Phase 3A@DWÙ.DWF.12-15 YearsA YNY. DWDWÙDWÙAðYEARSDSAC4591001C4591001 1066 10661431106614311066.DWFB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD©ìHrÆðlDW#DoÌHráLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD©ìHrÆðlDW#DoÌHráL......Phase 3A@DWÙ.DWF.12-15 YearsA YNY. DWDWÙDWÙAðYEARSDSA C4591001C4591001 1066 10661431106614311066.DWÙBËFOLLOW-UP BDISPOSITION EVENTOTHER Apsubject enrolled in C4591031 DWF..DWFYAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD©ìHrÆðlDW#DoÌHráLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD©ìHrÆðlDW#DoÌHráL......Phase 3A@DWÙ.DWF.12-15 YearsA YNY. DWDWÙDWÙAðYEARSDSAPC4591001C4591001 1066 10661432106614321066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWËDWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW¨D»¼Hs·¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW"D½$Hrà$DW’D—,Hss’,DW¨D»¼Hs·¼Phase 3A@..DWF.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1066 10661432106614321066.DWFB8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWËDWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW¨D»¼Hs·¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW"D½$Hrà$DW’D—,Hss’,DW¨D»¼Hs·¼Phase 3A@..DWF.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1066 10661432106614321066DW’DW’B„REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWËDWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW¨D»¼Hs·¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW"D½$Hrà$DW’D—,Hss’,DW¨D»¼Hs·¼Phase 3A@..DWF.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1066 10661432106614321066.DWËB½OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWËDWFYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW¨D»¼Hs·¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW’DW¨.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW"D½$Hrà$DW’D—,Hss’,DW¨D»¼Hs·¼Phase 3A@..DWF.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1066 10661433106614331066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÅDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáHrÇ'€DW¦D©°HsŽ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáHrÇ'€DW"DÔXHrà'XDW“D‰HstÕœDW¦D©°HsŽ°Phase 3A@..DWD.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1066 10661433106614331066.DWDB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÅDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáHrÇ'€DW¦D©°HsŽ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáHrÇ'€DW"DÔXHrà'XDW“D‰HstÕœDW¦D©°HsŽ°Phase 3A@..DWD.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1066 10661433106614331066DW“DW“B…REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÅDWD AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáHrÇ'€DW¦D©°HsŽ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáHrÇ'€DW"DÔXHrà'XDW“D‰HstÕœDW¦D©°HsŽ°Phase 3A@..DWD.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1066 10661433106614331066.DWÅB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÅDWDYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDáHrÇ'€DW¦D©°HsŽ°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW".DW“DW¦.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDáHrÇ'€DW"DÔXHrà'XDW“D‰HstÕœDW¦D©°HsŽ°Phase 3A@..DWD.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1066 10661434106614341066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWLDWÛ.DWL AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD®œHrÍŒœDW)D ŒHré.BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD®œHrÍŒœDW)D ŒHré.......Phase 3A@..DWLDWÛ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1066 10661434106614341066.DWLB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWLDWÛ.DWL AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD®œHrÍŒœDW)D ŒHré.BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD®œHrÍŒœDW)D ŒHré.......Phase 3A@..DWLDWÛ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1066 10661435106614351066DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWLDWÛ.DWL AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD®`HrÍŒ`DW)D ÈHré.HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD®`HrÍŒ`DW)D ÈHré.H......Phase 3A@..DWLDWÛ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1066 10661435106614351066.DWLB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWLDWÛ.DWL AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD®`HrÍŒ`DW)D ÈHré.HBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW)....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD®`HrÍŒ`DW)D ÈHré.H......Phase 3A@..DWLDWÛ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1077 10771274107712741077DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDÓhHr˜õhDVÿDê$Hr²¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDÓhHr˜õhDVÿDê$Hr²¤......Phase 3A@..DWDW®12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1077 10771274107712741077.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDÓhHr˜õhDVÿDê$Hr²¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDÓhHr˜õhDVÿDê$Hr²¤......Phase 3A@..DWDW®12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1077 10771275107712751077DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÓ¤Hr˜õ¤DW¦DÂHsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÓ¤Hr˜õ¤DVÿDêØHr²XDW‘DÈdHsrqäDW¦DÂHsŽPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1077 10771275107712751077.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÓ¤Hr˜õ¤DW¦DÂHsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÓ¤Hr˜õ¤DVÿDêØHr²XDW‘DÈdHsrqäDW¦DÂHsŽPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1077 10771275107712751077DW‘DW‘B¦REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÓ¤Hr˜õ¤DW¦DÂHsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÓ¤Hr˜õ¤DVÿDêØHr²XDW‘DÈdHsrqäDW¦DÂHsŽPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1077 10771275107712751077.DWÄBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDWYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÓ¤Hr˜õ¤DW¦DÂHsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDVÿ.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÓ¤Hr˜õ¤DVÿDêØHr²XDW‘DÈdHsrqäDW¦DÂHsŽPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1077 10771277107712771077DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÑDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‰”Hr™ýDW¯D¬DHs™âÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW˜DW¯.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD‰”Hr™ýDWDŽ€Hr³€DW˜D«Hs{DW¯D¬DHs™âÄPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1077 10771277107712771077.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÑDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‰”Hr™ýDW¯D¬DHs™âÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW˜DW¯.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD‰”Hr™ýDWDŽ€Hr³€DW˜D«Hs{DW¯D¬DHs™âÄPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1077 10771277107712771077DW˜DW˜B¬REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÑDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‰”Hr™ýDW¯D¬DHs™âÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW˜DW¯.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD‰”Hr™ýDWDŽ€Hr³€DW˜D«Hs{DW¯D¬DHs™âÄPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1077 10771277107712771077.DWÑBåOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÑDWYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD‰”Hr™ýDW¯D¬DHs™âÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW˜DW¯.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD‰”Hr™ýDWDŽ€Hr³€DW˜D«Hs{DW¯D¬DHs™âÄPhase 3A@..DW.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1077 10771278107712781077DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD‰Hr™üœDWDŽ¼Hr³¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD‰Hr™üœDWDŽ¼Hr³¼......Phase 3A@..DWDW¯12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1077 10771278107712781077.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD‰Hr™üœDWDŽ¼Hr³¼BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD‰Hr™üœDWDŽ¼Hr³¼......Phase 3A@..DWDW¯12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1077 10771279107712791077DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW½.DW) AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DœHr§$DWD‚HrÂÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DœHr§$DWD‚HrÂÔ......Phase 3A@..DW)DW½12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1077 10771279107712791077.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW½.DW) AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DœHr§$DWD‚HrÂÔBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DœHr§$DWD‚HrÂÔ......Phase 3A@..DW)DW½12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1077 10771280107712801077DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÍDW) AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D€èHr§#hDW±DštHsœsôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWœDW±.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D€èHr§#hDWD‚ŒHrÂÔŒDWœD¶XHs€àXDW±DštHsœsôPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1077 10771280107712801077.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÍDW) AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D€èHr§#hDW±DštHsœsôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWœDW±.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D€èHr§#hDWD‚ŒHrÂÔŒDWœD¶XHs€àXDW±DštHsœsôPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1077 10771280107712801077DWœDWœB¦REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÍDW) AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D€èHr§#hDW±DštHsœsôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWœDW±.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D€èHr§#hDWD‚ŒHrÂÔŒDWœD¶XHs€àXDW±DštHsœsôPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1077 10771280107712801077.DWÍB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÍDW)YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D€èHr§#hDW±DštHsœsôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DWœDW±.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D€èHr§#hDWD‚ŒHrÂÔŒDWœD¶XHs€àXDW±DštHsœsôPhase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1077 10771281107712811077DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÅ.DW) AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D‹tHr§-ôDWDÔ”HrÃ&”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D‹tHr§-ôDWDÔ”HrÃ&”......Phase 3A@..DW)DWÅ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1077 10771281107712811077.DW)B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÅ.DW) AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D‹tHr§-ôDWDÔ”HrÃ&”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D‹tHr§-ôDWDÔ”HrÃ&”......Phase 3A@..DW)DWÅ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1077 10771282107712821077DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DððHr§“pDW Dè¼HrÄŒ<Placebo Placebo 12-15 YearsA . . .DV÷DW ....DWPlacebo Placebo Placebo A .Placebo A .DV÷DððHr§“pDW Dè¼HrÄŒ<......Phase 3A@DW‘.DW+.12-15 YearsA YNN. DWŒDW‘DW‘AàYEARSDSAC4591001C4591001 1077 10771282107712821077.DW+B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DððHr§“pDW Dè¼HrÄŒ<Placebo Placebo 12-15 YearsA . . .DV÷DW ....DWPlacebo Placebo Placebo A .Placebo A .DV÷DððHr§“pDW Dè¼HrÄŒ<......Phase 3A@DW‘.DW+.12-15 YearsA YNN. DWŒDW‘DW‘AàYEARSDSA C4591001C4591001 1077 10771282107712821077.DW‘B›FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BSubject recieved covid-19 vaccine outside study and is moving. Does not wish to continue in followupDW+..DW+YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DððHr§“pDW Dè¼HrÄŒ<Placebo Placebo 12-15 YearsA . . .DV÷DW ....DWPlacebo Placebo Placebo A .Placebo A .DV÷DððHr§“pDW Dè¼HrÄŒ<......Phase 3A@DW‘.DW+.12-15 YearsA YNN. DWŒDW‘DW‘AàYEARSDSA`C4591001C4591001 1077 10771283107712831077DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÄDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD‚ÈHr¨vÈDW§DuäHs dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD‚ÈHr¨vÈDWDrœHrÅgœDW‘DvÔHsr TDW§DuäHs dPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1077 10771283107712831077.DW*B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÄDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD‚ÈHr¨vÈDW§DuäHs dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD‚ÈHr¨vÈDWDrœHrÅgœDW‘DvÔHsr TDW§DuäHs dPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1077 10771283107712831077DW‘DW‘BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÄDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD‚ÈHr¨vÈDW§DuäHs dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD‚ÈHr¨vÈDWDrœHrÅgœDW‘DvÔHsr TDW§DuäHs dPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1077 10771283107712831077.DWÄBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÄDW*YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD‚ÈHr¨vÈDW§DuäHs dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD‚ÈHr¨vÈDWDrœHrÅgœDW‘DvÔHsr TDW§DuäHs dPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1077 10771284107712841077DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW».DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD‚PHr¨vPDWDr$HrÅg$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWABNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD‚PHr¨vPDWDr$HrÅg$......Phase 3A@..DW*DW»12-15 YearsAYYNY. DW@DWýDWýAðYEARSDSAC4591001C4591001 1077 10771284107712841077.DW*B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW».DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD‚PHr¨vPDWDr$HrÅg$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWABNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD‚PHr¨vPDWDr$HrÅg$......Phase 3A@..DW*DW»12-15 YearsAYYNY. DW@DWýDWýAðYEARSDSA C4591001C4591001 1077 10771285107712851077DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÄDW, AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDƒ@Hr¨w@DW¦D|8HsÕ8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDƒ@Hr¨w@DWDyàHrÆÀ`DW’Dr`Hssm`DW¦D|8HsÕ8Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1077 10771285107712851077.DW,B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÄDW, AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDƒ@Hr¨w@DW¦D|8HsÕ8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDƒ@Hr¨w@DWDyàHrÆÀ`DW’Dr`Hssm`DW¦D|8HsÕ8Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1077 10771285107712851077DW’DW’B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÄDW, AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDƒ@Hr¨w@DW¦D|8HsÕ8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDƒ@Hr¨w@DWDyàHrÆÀ`DW’Dr`Hssm`DW¦D|8HsÕ8Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1077 10771285107712851077.DWÄBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÄDW,YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDƒ@Hr¨w@DW¦D|8HsÕ8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDƒ@Hr¨w@DWDyàHrÆÀ`DW’Dr`Hssm`DW¦D|8HsÕ8Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1077 10771286107712861077DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¿.DW* AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÅ”Hr¨¹”DWDž4HrÂð4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÅ”Hr¨¹”DWDž4HrÂð4......Phase 3A@..DW*DW¿12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1077 10771286107712861077.DW*B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¿.DW* AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÅ”Hr¨¹”DWDž4HrÂð4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÅ”Hr¨¹”DWDž4HrÂð4......Phase 3A@..DW*DW¿12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1077 10771287107712871077DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÃ.DW6 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÊ¼Hr¨¾¼DWD«HrÅ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÊ¼Hr¨¾¼DWD«HrÅ ......Phase 3A@..DW6DWÃ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1077 10771287107712871077.DW6B?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÃ.DW6 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÊ¼Hr¨¾¼DWD«HrÅ BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÊ¼Hr¨¾¼DWD«HrÅ ......Phase 3A@..DW6DWÃ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1077 10771288107712881077DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÉ.DW+ AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÙøHrªxDWD—¤HrÅŒ¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÙøHrªxDWD—¤HrÅŒ¤......Phase 3A@..DW+DWÉ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1077 10771288107712881077.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÉ.DW+ AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÙøHrªxDWD—¤HrÅŒ¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÙøHrªxDWD—¤HrÅŒ¤......Phase 3A@..DW+DWÉ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1077 10771289107712891077DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3..DW3 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÔHr¬¼œDWDÍPHrÈePPlacebo Placebo 12-15 YearsA . . .DVûDW....DWPlacebo Placebo Placebo A .Placebo A .DVûDÔHr¬¼œDWDÍPHrÈeP......Phase 3A@DWŽ.DW3.12-15 YearsA YNN. DWŒDWŽDWŽAàYEARSDSAC4591001C4591001 1077 10771289107712891077.DW3B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3..DW3 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÔHr¬¼œDWDÍPHrÈePPlacebo Placebo 12-15 YearsA . . .DVûDW....DWPlacebo Placebo Placebo A .Placebo A .DVûDÔHr¬¼œDWDÍPHrÈeP......Phase 3A@DWŽ.DW3.12-15 YearsA YNN. DWŒDWŽDWŽAàYEARSDSA C4591001C4591001 1077 10771289107712891077.DWŽB”FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BWITHDRAWAL BY PARENT/GUARDIAN DW3..DW3YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÔHr¬¼œDWDÍPHrÈePPlacebo Placebo 12-15 YearsA . . .DVûDW....DWPlacebo Placebo Placebo A .Placebo A .DVûDÔHr¬¼œDWDÍPHrÈeP......Phase 3A@DWŽ.DW3.12-15 YearsA YNN. DWŒDWŽDWŽAàYEARSDSA`C4591001C4591001 1077 10771290107712901077DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3..DW3 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÔXHr¬¼ØDWDÍÈHrÈeÈPlacebo Placebo 12-15 YearsA . . .DVûDW....DWŽPlacebo Placebo Placebo A .Placebo A .DVûDÔXHr¬¼ØDWDÍÈHrÈeÈ......Phase 3A@DWŽ.DW3.12-15 YearsA YNN. DWDWŽDWŽAàYEARSDSAC4591001C4591001 1077 10771290107712901077.DW3B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3..DW3 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÔXHr¬¼ØDWDÍÈHrÈeÈPlacebo Placebo 12-15 YearsA . . .DVûDW....DWŽPlacebo Placebo Placebo A .Placebo A .DVûDÔXHr¬¼ØDWDÍÈHrÈeÈ......Phase 3A@DWŽ.DW3.12-15 YearsA YNN. DWDWŽDWŽAàYEARSDSA C4591001C4591001 1077 10771290107712901077.DWŽB”FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BWITHDRAWAL BY PARENT/GUARDIAN DW3..DW3YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÔXHr¬¼ØDWDÍÈHrÈeÈPlacebo Placebo 12-15 YearsA . . .DVûDW....DWŽPlacebo Placebo Placebo A .Placebo A .DVûDÔXHr¬¼ØDWDÍÈHrÈeÈ......Phase 3A@DWŽ.DW3.12-15 YearsA YNN. DWDWŽDWŽAàYEARSDSA`C4591001C4591001 1077 10771291107712911077DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DW½.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDãXHr¬ËØDWD¯ŒHrÅ¤ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWABNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDãXHr¬ËØDWD¯ŒHrÅ¤Œ......Phase 3A@..DW1DW½12-15 YearsA YNY. DW@DWýDWýAðYEARSDSAC4591001C4591001 1077 10771291107712911077.DW1B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DW½.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDãXHr¬ËØDWD¯ŒHrÅ¤ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWABNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDãXHr¬ËØDWD¯ŒHrÅ¤Œ......Phase 3A@..DW1DW½12-15 YearsA YNY. DW@DWýDWýAðYEARSDSA C4591001C4591001 1077 10771292107712921077DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDã”Hr¬ÌDWD¯ÈHrÅ¤ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW‹BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDã”Hr¬ÌDWD¯ÈHrÅ¤È......Phase 3A@DW’.DW1.12-15 YearsAYYNN. DWŠDW’DW’AàYEARSDSAC4591001C4591001 1077 10771292107712921077.DW1B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDã”Hr¬ÌDWD¯ÈHrÅ¤ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW‹BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDã”Hr¬ÌDWD¯ÈHrÅ¤È......Phase 3A@DW’.DW1.12-15 YearsAYYNN. DWŠDW’DW’AàYEARSDSA C4591001C4591001 1077 10771292107712921077.DW’B˜FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BWITHDRAWAL BY PARENT/GUARDIAN DW1..DW1YAàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDã”Hr¬ÌDWD¯ÈHrÅ¤ÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW‹BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDã”Hr¬ÌDWD¯ÈHrÅ¤È......Phase 3A@DW’.DW1.12-15 YearsAYYNN. DWŠDW’DW’AàYEARSDSA`C4591001C4591001 1077 10771293107712931077DVûDVû.SCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED .... AÀYEARSMAWHITE AWHITE AYNPlacebo PLACEBO Not Treated NOTTRT ......Placebo 12-15 YearsA . . ........ . .Placebo A .............Phase 3A@DVû...12-15 YearsA NN. DVû.DVûAÀYEARSDSAC4591001C4591001 1077 10771293107712931077.DVû.FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject withdrew consent prior to blood draw. .... AÀYEARSMAWHITE AWHITE AYNPlacebo PLACEBO Not Treated NOTTRT ......Placebo 12-15 YearsA . . ........ . .Placebo A .............Phase 3A@DVû...12-15 YearsA NN. DVû.DVûAÀYEARSDSA@C4591001C4591001 1077 10771294107712941077DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÍDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¾Hr¹Õ”DW±DÇ8Hsœ ¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW±.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¾Hr¹Õ”DWD»HrØ%DW˜DÐ Hs{´ DW±DÇ8Hsœ ¸Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1077 10771294107712941077.DW=B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÍDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¾Hr¹Õ”DW±DÇ8Hsœ ¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW±.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¾Hr¹Õ”DWD»HrØ%DW˜DÐ Hs{´ DW±DÇ8Hsœ ¸Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1077 10771294107712941077DW˜DW˜B”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÍDW= AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¾Hr¹Õ”DW±DÇ8Hsœ ¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW±.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¾Hr¹Õ”DWD»HrØ%DW˜DÐ Hs{´ DW±DÇ8Hsœ ¸Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1077 10771294107712941077.DWÍBÉOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÍDW=YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¾Hr¹Õ”DW±DÇ8Hsœ ¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW˜DW±.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¾Hr¹Õ”DWD»HrØ%DW˜DÐ Hs{´ DW±DÇ8Hsœ ¸Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1077 10771295107712951077DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWpDW8 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÆ„Hr¹ÞDWTDÂˆHs"ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW@DWT.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÆ„Hr¹ÞDWDÅXHrØ/XDW@DßÔHs¿ÔDWTDÂˆHs"ˆPhase 3A@..DW8.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSAC4591001C4591001 1077 10771295107712951077.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWpDW8 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÆ„Hr¹ÞDWTDÂˆHs"ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW@DWT.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÆ„Hr¹ÞDWDÅXHrØ/XDW@DßÔHs¿ÔDWTDÂˆHs"ˆPhase 3A@..DW8.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA C4591001C4591001 1077 10771295107712951077DW@DW@B<REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWpDW8 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÆ„Hr¹ÞDWTDÂˆHs"ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW@DWT.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÆ„Hr¹ÞDWDÅXHrØ/XDW@DßÔHs¿ÔDWTDÂˆHs"ˆPhase 3A@..DW8.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA0C4591001C4591001 1077 10771295107712951077.DWpBlOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWpDW8YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÆ„Hr¹ÞDWTDÂˆHs"ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW@DWT.DW=Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÆ„Hr¹ÞDWDÅXHrØ/XDW@DßÔHs¿ÔDWTDÂˆHs"ˆPhase 3A@..DW8.12-15 YearsA YNN. DW<DWýDWýAðYEARSDSA@C4591001C4591001 1077 10771296107712961077DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÄ.DW8 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¨ÀHr»ÀDWDHrØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¨ÀHr»ÀDWDHrØ......Phase 3A@..DW8DWÄ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1077 10771296107712961077.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÄ.DW8 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¨ÀHr»ÀDWDHrØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¨ÀHr»ÀDWDHrØ......Phase 3A@..DW8DWÄ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1077 10771297107712971077DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÛ.DW@ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÏ¨HrÅÄ¨DW$DÞ¨HrâÔ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÏ¨HrÅÄ¨DW$DÞ¨HrâÔ¨......Phase 3A@..DW@DWÛ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1077 10771297107712971077.DW@B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÛ.DW@ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÏ¨HrÅÄ¨DW$DÞ¨HrâÔ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW$....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÏ¨HrÅÄ¨DW$DÞ¨HrâÔ¨......Phase 3A@..DW@DWÛ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1077 10771298107712981077DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW£Dß\HsŠCÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW#D¶XHráZØDWŽDå8Hsnš8DW£Dß\HsŠCÜPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1077 10771298107712981077.DW?B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW£Dß\HsŠCÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW#D¶XHráZØDWŽDå8Hsnš8DW£Dß\HsŠCÜPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1077 10771298107712981077DWŽDWŽB€REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW£Dß\HsŠCÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW#D¶XHráZØDWŽDå8Hsnš8DW£Dß\HsŠCÜPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1077 10771298107712981077.DWÄB¶OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW?YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÆóðDW£Dß\HsŠCÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWŽDW£.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÆóðDW#D¶XHráZØDWŽDå8Hsnš8DW£Dß\HsŠCÜPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1077 10771299107712991077DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÒ.DWA AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDË¬HrÇ,DW#DÀ¨Hráe(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDË¬HrÇ,DW#DÀ¨Hráe(......Phase 3A@..DWADWÒ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1077 10771299107712991077.DWAB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÒ.DWA AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDË¬HrÇ,DW#DÀ¨Hráe(BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDË¬HrÇ,DW#DÀ¨Hráe(......Phase 3A@..DWADWÒ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1077 10771300107713001077DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÓ.DW? AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDéèHrÇ0hDW#DäÀHrá‰@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWƒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDéèHrÇ0hDW#DäÀHrá‰@......Phase 3A@..DW?DWÓ12-15 YearsA YNY. DW‚DWýDWýAðYEARSDSAC4591001C4591001 1077 10771300107713001077.DW?B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÓ.DW? AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDéèHrÇ0hDW#DäÀHrá‰@BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWƒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDéèHrÇ0hDW#DäÀHrá‰@......Phase 3A@..DW?DWÓ12-15 YearsA YNY. DW‚DWýDWýAðYEARSDSA C4591001C4591001 1084 10841541108415411084DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¸.DW% AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÌHr£;ÌDWDÝ|Hr¼—üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÌHr£;ÌDWDÝ|Hr¼—ü......Phase 3A@..DW%DW¸12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1084 10841541108415411084.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¸.DW% AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDÌHr£;ÌDWDÝ|Hr¼—üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDÌHr£;ÌDWDÝ|Hr¼—ü......Phase 3A@..DW%DW¸12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1084 10841542108415421084DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%..DW% AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVôD©ìHr£WìDWDÙøHr¼”xPlacebo Placebo 12-15 YearsA . . .DVôDW....DWPlacebo Placebo Placebo A .Placebo A .DVôD©ìHr£WìDWDÙøHr¼”x......Phase 3A@DW¾.DW%.12-15 YearsA YNN. DWŒDW¾DW¾AðYEARSDSAC4591001C4591001 1084 10841542108415421084.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%..DW% AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVôD©ìHr£WìDWDÙøHr¼”xPlacebo Placebo 12-15 YearsA . . .DVôDW....DWPlacebo Placebo Placebo A .Placebo A .DVôD©ìHr£WìDWDÙøHr¼”x......Phase 3A@DW¾.DW%.12-15 YearsA YNN. DWŒDW¾DW¾AðYEARSDSA C4591001C4591001 1084 10841542108415421084.DW¾BËFOLLOW-UP BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABsubject received vaccine outside of study. DW%..DW%YAðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVôD©ìHr£WìDWDÙøHr¼”xPlacebo Placebo 12-15 YearsA . . .DVôDW....DWPlacebo Placebo Placebo A .Placebo A .DVôD©ìHr£WìDWDÙøHr¼”x......Phase 3A@DW¾.DW%.12-15 YearsA YNN. DWŒDW¾DW¾AðYEARSDSAPC4591001C4591001 1084 10841543108415431084DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÂDW, AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDèDHr¬ÐÄDW¦DÛ`HsŽ4`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDèDHr¬ÐÄDWDàLHrÈxLDW‘DäüHsrŽ|DW¦DÛ`HsŽ4`Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841543108415431084.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÂDW, AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDèDHr¬ÐÄDW¦DÛ`HsŽ4`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDèDHr¬ÐÄDWDàLHrÈxLDW‘DäüHsrŽ|DW¦DÛ`HsŽ4`Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841543108415431084DW‘DW‘B—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÂDW, AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDèDHr¬ÐÄDW¦DÛ`HsŽ4`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDèDHr¬ÐÄDWDàLHrÈxLDW‘DäüHsrŽ|DW¦DÛ`HsŽ4`Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1084 10841543108415431084.DWÂBÈOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÂDW,YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDèDHr¬ÐÄDW¦DÛ`HsŽ4`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW‘DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDèDHr¬ÐÄDWDàLHrÈxLDW‘DäüHsrŽ|DW¦DÛ`HsŽ4`Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1084 10841544108415441084DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW½.DW, AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDó„Hr¬ÜDWDçÌHrÅÜÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDó„Hr¬ÜDWDçÌHrÅÜÌ......Phase 3A@..DW,DW½12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1084 10841544108415441084.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW½.DW, AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDó„Hr¬ÜDWDçÌHrÅÜÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDó„Hr¬ÜDWDçÌHrÅÜÌ......Phase 3A@..DW,DW½12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1084 10841545108415451084DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDôìHr¬ÝlDW¨D€Hs{€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDôìHr¬ÝlDWDè¼HrÅÝ¼DW’DçÌHssâÌDW¨D€Hs{€Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841545108415451084.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDôìHr¬ÝlDW¨D€Hs{€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDôìHr¬ÝlDWDè¼HrÅÝ¼DW’DçÌHssâÌDW¨D€Hs{€Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841545108415451084DW’DW’B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW, AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDôìHr¬ÝlDW¨D€Hs{€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDôìHr¬ÝlDWDè¼HrÅÝ¼DW’DçÌHssâÌDW¨D€Hs{€Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1084 10841545108415451084.DWÃBÉOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÃDW,YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDôìHr¬ÝlDW¨D€Hs{€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDôìHr¬ÝlDWDè¼HrÅÝ¼DW’DçÌHssâÌDW¨D€Hs{€Phase 3A@..DW,.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1084 10841546108415461084DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DW½.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDöHr¬Þ˜DWDépHrÅÞpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDöHr¬Þ˜DWDépHrÅÞp......Phase 3A@..DW,DW½12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1084 10841546108415461084.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DW½.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDöHr¬Þ˜DWDépHrÅÞpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDöHr¬Þ˜DWDépHrÅÞp......Phase 3A@..DW,DW½12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1084 10841547108415471084DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDŒ Hr°i DW¨DøHs™øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDŒ Hr°i DWDÓàHrÏ`DW•D€4Hswo´DW¨DøHs™øPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1084 10841547108415471084.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDŒ Hr°i DW¨DøHs™øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDŒ Hr°i DWDÓàHrÏ`DW•D€4Hswo´DW¨DøHs™øPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1084 10841547108415471084DW•DW•B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDŒ Hr°i DW¨DøHs™øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDŒ Hr°i DWDÓàHrÏ`DW•D€4Hswo´DW¨DøHs™øPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1084 10841547108415471084.DWÄBÇOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDŒ Hr°i DW¨DøHs™øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDŒ Hr°i DWDÓàHrÏ`DW•D€4Hswo´DW¨DøHs™øPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1084 10841548108415481084DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÆ.DW3 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÍPHr°ªPDWDßÔHrÏTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÍPHr°ªPDWDßÔHrÏT......Phase 3A@..DW3DWÆ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1084 10841548108415481084.DW3B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÆ.DW3 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÍPHr°ªPDWDßÔHrÏTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÍPHr°ªPDWDßÔHrÏT......Phase 3A@..DW3DWÆ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1084 10841549108415491084DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÉ.DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¦àHr°ƒàDWD”˜HrÌ!BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¦àHr°ƒàDWD”˜HrÌ!......Phase 3A@..DW1DWÉ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1084 10841549108415491084.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÉ.DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¦àHr°ƒàDWD”˜HrÌ!BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¦àHr°ƒàDWD”˜HrÌ!......Phase 3A@..DW1DWÉ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1084 10841550108415501084DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3..DW3 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÎ|Hr°«|DWõD¬Hsö,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWÞDWõ.DWÞPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÎ|Hr°«|DWDÜŒHrÏDWÞDÄ¤Hs×ñ¤DWõD¬Hsö,Phase 3A@..DW3.12-15 YearsA YNN. DWÝDWýDWýAðYEARSDSAC4591001C4591001 1084 10841550108415501084.DW3B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3..DW3 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÎ|Hr°«|DWõD¬Hsö,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWÞDWõ.DWÞPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÎ|Hr°«|DWDÜŒHrÏDWÞDÄ¤Hs×ñ¤DWõD¬Hsö,Phase 3A@..DW3.12-15 YearsA YNN. DWÝDWýDWýAðYEARSDSA C4591001C4591001 1084 10841550108415501084DWÞDWÞBáREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW3..DW3 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÎ|Hr°«|DWõD¬Hsö,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWÞDWõ.DWÞPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÎ|Hr°«|DWDÜŒHrÏDWÞDÄ¤Hs×ñ¤DWõD¬Hsö,Phase 3A@..DW3.12-15 YearsA YNN. DWÝDWýDWýAðYEARSDSA0C4591001C4591001 1084 10841551108415511084DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÞ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÏäHr°¬äDWDÛØHrÏXBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÏäHr°¬äDWDÛØHrÏX......Phase 3A@..DW3DWÞ12-15 YearsA YNY. DWý.DWýAÐYEARSDSAC4591001C4591001 1084 10841551108415511084.DW3B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÞ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÏäHr°¬äDWDÛØHrÏXBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÏäHr°¬äDWDÛØHrÏX......Phase 3A@..DW3DWÞ12-15 YearsA YNY. DWý.DWýAÐYEARSDSA C4591001C4591001 1084 10841552108415521084DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÊDW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÑLHr°®LDWªD»¼Hs“Z¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW˜DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÑLHr°®LDWDäHrÌpŒDW˜DëÈHs{ÏÈDWªD»¼Hs“Z¼Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1084 10841552108415521084.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÊDW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÑLHr°®LDWªD»¼Hs“Z¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW˜DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÑLHr°®LDWDäHrÌpŒDW˜DëÈHs{ÏÈDWªD»¼Hs“Z¼Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1084 10841552108415521084DW˜DW˜B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÊDW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÑLHr°®LDWªD»¼Hs“Z¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW˜DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÑLHr°®LDWDäHrÌpŒDW˜DëÈHs{ÏÈDWªD»¼Hs“Z¼Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1084 10841552108415521084.DWÊBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWÊDW/YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÑLHr°®LDWªD»¼Hs“Z¼Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW˜DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÑLHr°®LDWDäHrÌpŒDW˜DëÈHs{ÏÈDWªD»¼Hs“Z¼Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1084 10841553108415531084DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÄ.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDäHr°ÁDWDœHrÌ(˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDäHr°ÁDWDœHrÌ(˜......Phase 3A@..DW1DWÄ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1084 10841553108415531084.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÄ.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDäHr°ÁDWDœHrÌ(˜BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDäHr°ÁDWDœHrÌ(˜......Phase 3A@..DW1DWÄ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1084 10841555108415551084DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDèHr°ÅDWðD“0Hsï{0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWÛDWð.DW×Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDèHr°ÅDWDÕüHrÌb|DWÛDÜHsÔ”DWðD“0Hsï{0Phase 3A@..DW/.12-15 YearsA YNN. DWÖDWýDWýAÐYEARSDSAC4591001C4591001 1084 10841555108415551084.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDèHr°ÅDWðD“0Hsï{0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWÛDWð.DW×Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDèHr°ÅDWDÕüHrÌb|DWÛDÜHsÔ”DWðD“0Hsï{0Phase 3A@..DW/.12-15 YearsA YNN. DWÖDWýDWýAÐYEARSDSA C4591001C4591001 1084 10841555108415551084DWÛDWÛBÞREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDèHr°ÅDWðD“0Hsï{0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWÛDWð.DW×Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDèHr°ÅDWDÕüHrÌb|DWÛDÜHsÔ”DWðD“0Hsï{0Phase 3A@..DW/.12-15 YearsA YNN. DWÖDWýDWýAÐYEARSDSA0C4591001C4591001 1084 10841556108415561084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDHr¹´ˆDWD`HrÕH`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDHr¹´ˆDWD`HrÕH`......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1084 10841556108415561084.DW=B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDHr¹´ˆDWD`HrÕH`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDHr¹´ˆDWD`HrÕH`......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1084 10841557108415571084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@..DW@ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHr¹«dDWDƒ|HrÕJ|Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWD“äHr¹«dDWDƒ|HrÕJ|......Phase 3A@DW.DW@.12-15 YearsA YNN. DWŒDWDWAÐYEARSDSAC4591001C4591001 1084 10841557108415571084.DW@B<VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@..DW@ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHr¹«dDWDƒ|HrÕJ|Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWD“äHr¹«dDWDƒ|HrÕJ|......Phase 3A@DW.DW@.12-15 YearsA YNN. DWŒDWDWAÐYEARSDSA C4591001C4591001 1084 10841557108415571084.DWB‰FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BWITHDRAWAL BY PARENT/GUARDIAN DW@..DW@YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD“äHr¹«dDWDƒ|HrÕJ|Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWD“äHr¹«dDWDƒ|HrÕJ|......Phase 3A@DW.DW@.12-15 YearsA YNN. DWŒDWDWAÐYEARSDSApC4591001C4591001 1084 10841558108415581084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDºHr¹Ñ˜DWD4HrÕV4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDºHr¹Ñ˜DWD4HrÕV4......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1084 10841558108415581084.DW=B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDºHr¹Ñ˜DWD4HrÕV4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDºHr¹Ñ˜DWD4HrÕV4......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1084 10841559108415591084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÀäHr¹ØdDWDHrÕTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÀäHr¹ØdDWDHrÕT......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1084 10841559108415591084.DW=B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÀäHr¹ØdDWDHrÕTBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÀäHr¹ØdDWDHrÕT......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1084 10841560108415601084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÐDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD´xHr¹ËøDW´D ÈHs nÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW´.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´xHr¹ËøDWDîÔHrÚûÔDWœDÐ˜Hs€ú˜DW´D ÈHs nÈPhase 3A@..DW@.12-15 YearsA YNN. DW“DWýDWýAðYEARSDSAC4591001C4591001 1084 10841560108415601084.DW@B<VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÐDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD´xHr¹ËøDW´D ÈHs nÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW´.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´xHr¹ËøDWDîÔHrÚûÔDWœDÐ˜Hs€ú˜DW´D ÈHs nÈPhase 3A@..DW@.12-15 YearsA YNN. DW“DWýDWýAðYEARSDSA C4591001C4591001 1084 10841560108415601084DWœDWœB˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÐDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD´xHr¹ËøDW´D ÈHs nÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW´.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´xHr¹ËøDWDîÔHrÚûÔDWœDÐ˜Hs€ú˜DW´D ÈHs nÈPhase 3A@..DW@.12-15 YearsA YNN. DW“DWýDWýAðYEARSDSA0C4591001C4591001 1084 10841560108415601084.DWÐBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÐDW@YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD´xHr¹ËøDW´D ÈHs nÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW´.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´xHr¹ËøDWDîÔHrÚûÔDWœDÐ˜Hs€ú˜DW´D ÈHs nÈPhase 3A@..DW@.12-15 YearsA YNN. DW“DWýDWýAðYEARSDSA@C4591001C4591001 1084 10841561108415611084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÂDW= AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÃHr¹Ú€DW¦DÆüHsŽüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÃHr¹Ú€DWD”˜HrÕ[˜DW‘Dæ(Hsr¨DW¦DÆüHsŽüPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1084 10841561108415611084.DW=B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÂDW= AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÃHr¹Ú€DW¦DÆüHsŽüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÃHr¹Ú€DWD”˜HrÕ[˜DW‘Dæ(Hsr¨DW¦DÆüHsŽüPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1084 10841561108415611084DW‘DW‘BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÂDW= AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÃHr¹Ú€DW¦DÆüHsŽüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÃHr¹Ú€DWD”˜HrÕ[˜DW‘Dæ(Hsr¨DW¦DÆüHsŽüPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1084 10841561108415611084.DWÂB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÂDW=YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÃHr¹Ú€DW¦DÆüHsŽüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÃHr¹Ú€DWD”˜HrÕ[˜DW‘Dæ(Hsr¨DW¦DÆüHsŽüPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1084 10841562108415621084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDáHr¹ø€DWD˜XHrÕ_XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDáHr¹ø€DWD˜XHrÕ_X......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DWý.DWýAÀYEARSDSAC4591001C4591001 1084 10841562108415621084.DW=B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDáHr¹ø€DWD˜XHrÕ_XBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDáHr¹ø€DWD˜XHrÕ_X......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DWý.DWýAÀYEARSDSA C4591001C4591001 1084 10841563108415631084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœHr¼V˜DWD HrÕgBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœHr¼V˜DWD HrÕg......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1084 10841563108415631084.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÉ.DW= AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœHr¼V˜DWD HrÕgBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœHr¼V˜DWD HrÕg......Phase 3A@..DW=DWÉ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1084 10841564108415641084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWáDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœÌHr¼WLDWªDÍŒHs“lŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDœÌHr¼WLDWDœTHrÕcTDW•DÃ<Hsw²¼DWªDÍŒHs“lŒPhase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841564108415641084.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWáDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœÌHr¼WLDWªDÍŒHs“lŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDœÌHr¼WLDWDœTHrÕcTDW•DÃ<Hsw²¼DWªDÍŒHs“lŒPhase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841564108415641084DW•DW•BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWáDW= AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœÌHr¼WLDWªDÍŒHs“lŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDœÌHr¼WLDWDœTHrÕcTDW•DÃ<Hsw²¼DWªDÍŒHs“lŒPhase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1084 10841564108415641084.DWáBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWáDW=YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDœÌHr¼WLDWªDÍŒHs“lŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDœÌHr¼WLDWDœTHrÕcTDW•DÃ<Hsw²¼DWªDÍŒHs“lŒPhase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1084 10841565108415651084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD«THr¼eÔDWªDÎ@Hs“m@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD«THr¼eÔDWDæÜHrØPÜDW•D€¬Hswp,DWªDÎ@Hs“m@Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1084 10841565108415651084.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD«THr¼eÔDWªDÎ@Hs“m@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD«THr¼eÔDWDæÜHrØPÜDW•D€¬Hswp,DWªDÎ@Hs“m@Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1084 10841565108415651084DW•DW•BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD«THr¼eÔDWªDÎ@Hs“m@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD«THr¼eÔDWDæÜHrØPÜDW•D€¬Hswp,DWªDÎ@Hs“m@Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1084 10841565108415651084.DWÄB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW=YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD«THr¼eÔDWªDÎ@Hs“m@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD«THr¼eÔDWDæÜHrØPÜDW•D€¬Hswp,DWªDÎ@Hs“m@Phase 3A@..DW=.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1084 10841566108415661084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÀlHr¼zìDWD–xHrÕ]xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÀlHr¼zìDWD–xHrÕ]x......Phase 3A@..DW=DW×12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1084 10841566108415661084.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DW×.DW= AðYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÀlHr¼zìDWD–xHrÕ]xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÀlHr¼zìDWD–xHrÕ]x......Phase 3A@..DW=DW×12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1084 10841567108415671084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÉ.DW? AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÉTHr¼ƒÔDWDÛ`HrÕ¢`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÉTHr¼ƒÔDWDÛ`HrÕ¢`......Phase 3A@..DW?DWÉ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1084 10841567108415671084.DW?B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÉ.DW? AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÉTHr¼ƒÔDWDÛ`HrÕ¢`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÉTHr¼ƒÔDWDÛ`HrÕ¢`......Phase 3A@..DW?DWÉ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1084 10841568108415681084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWK..DWK AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD×ÜHr¼’\DWD™HHrÕ`HPlacebo Placebo 12-15 YearsA . . .DWDW....DW Placebo Placebo Placebo A .Placebo A .DWD×ÜHr¼’\DWD™HHrÕ`H......Phase 3A@DW®.DWK.12-15 YearsA YNN. DWŸDW®DW®AðYEARSDSAC4591001C4591001 1084 10841568108415681084.DWKBEVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWK..DWK AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD×ÜHr¼’\DWD™HHrÕ`HPlacebo Placebo 12-15 YearsA . . .DWDW....DW Placebo Placebo Placebo A .Placebo A .DWD×ÜHr¼’\DWD™HHrÕ`H......Phase 3A@DW®.DWK.12-15 YearsA YNN. DWŸDW®DW®AðYEARSDSA C4591001C4591001 1084 10841568108415681084.DW®B¨FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT Bsubject drop to due summer activities DWK..DWKYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD×ÜHr¼’\DWD™HHrÕ`HPlacebo Placebo 12-15 YearsA . . .DWDW....DW Placebo Placebo Placebo A .Placebo A .DWD×ÜHr¼’\DWD™HHrÕ`H......Phase 3A@DW®.DWK.12-15 YearsA YNN. DWŸDW®DW®AðYEARSDSApC4591001C4591001 1084 10841569108415691084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDè¼Hr¼£<DWªD›ÜHs“:ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDè¼Hr¼£<DWDê`HrÚ÷`DW•DêØHswÚXDWªD›ÜHs“:ÜPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1084 10841569108415691084.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDè¼Hr¼£<DWªD›ÜHs“:ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDè¼Hr¼£<DWDê`HrÚ÷`DW•DêØHswÚXDWªD›ÜHs“:ÜPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1084 10841569108415691084DW•DW•BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDè¼Hr¼£<DWªD›ÜHs“:ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDè¼Hr¼£<DWDê`HrÚ÷`DW•DêØHswÚXDWªD›ÜHs“:ÜPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1084 10841569108415691084.DWÄB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW=YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDè¼Hr¼£<DWªD›ÜHs“:ÜPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDè¼Hr¼£<DWDê`HrÚ÷`DW•DêØHswÚXDWªD›ÜHs“:ÜPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1084 10841570108415701084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDépHr¼£ðDWªDœTHs“;TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDépHr¼£ðDWDé¬HrÚö¬DW•DëPHswÚÐDWªDœTHs“;TPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1084 10841570108415701084.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDépHr¼£ðDWªDœTHs“;TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDépHr¼£ðDWDé¬HrÚö¬DW•DëPHswÚÐDWªDœTHs“;TPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1084 10841570108415701084DW•DW•BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW= AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDépHr¼£ðDWªDœTHs“;TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDépHr¼£ðDWDé¬HrÚö¬DW•DëPHswÚÐDWªDœTHs“;TPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1084 10841570108415701084.DWÄB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÄDW=YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDépHr¼£ðDWªDœTHs“;TPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDépHr¼£ðDWDé¬HrÚö¬DW•DëPHswÚÐDWªDœTHs“;TPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1084 10841571108415711084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWüDW= AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDëHr¼¥”DWàDöHsÚÆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWà.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëHr¼¥”DWDÕ„HrØ?„DW•DÎ@Hsw½ÀDWàDöHsÚÆPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1084 10841571108415711084.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWüDW= AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDëHr¼¥”DWàDöHsÚÆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWà.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëHr¼¥”DWDÕ„HrØ?„DW•DÎ@Hsw½ÀDWàDöHsÚÆPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1084 10841571108415711084DW•DW•BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWüDW= AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDëHr¼¥”DWàDöHsÚÆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWà.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëHr¼¥”DWDÕ„HrØ?„DW•DÎ@Hsw½ÀDWàDöHsÚÆPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1084 10841571108415711084.DWüBöOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWüDW=YAðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDëHr¼¥”DWàDöHsÚÆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWà.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDëHr¼¥”DWDÕ„HrØ?„DW•DÎ@Hsw½ÀDWàDöHsÚÆPhase 3A@..DW=.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1084 10841572108415721084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÍDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÂápDW±DÍHsœ¦”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWœDW±.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÂápDW!Dæ HrÞè DWœDàÄHs ÄDW±DÍHsœ¦”Phase 3A@..DW?.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSAC4591001C4591001 1084 10841572108415721084.DW?B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÍDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÂápDW±DÍHsœ¦”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWœDW±.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÂápDW!Dæ HrÞè DWœDàÄHs ÄDW±DÍHsœ¦”Phase 3A@..DW?.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA C4591001C4591001 1084 10841572108415721084DWœDWœB‘REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÍDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÂápDW±DÍHsœ¦”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWœDW±.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÂápDW!Dæ HrÞè DWœDàÄHs ÄDW±DÍHsœ¦”Phase 3A@..DW?.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA0C4591001C4591001 1084 10841572108415721084.DWÍBÂOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÍDW?YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHrÂápDW±DÍHsœ¦”Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW!.DWœDW±.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHrÂápDW!Dæ HrÞè DWœDàÄHs ÄDW±DÍHsœ¦”Phase 3A@..DW?.12-15 YearsA YNN. DW”DWýDWýAÐYEARSDSA@C4591001C4591001 1084 10841573108415731084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèHrÃ:DW#DÜÈHráHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèHrÃ:DW#DÜÈHráH......Phase 3A@..DWADWÙ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841573108415731084.DWAB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèHrÃ:DW#DÜÈHráHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèHrÃ:DW#DÜÈHráH......Phase 3A@..DWADWÙ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841574108415741084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDéèHrÃ;èDW#DÚ4Hrá~´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDéèHrÃ;èDW#DÚ4Hrá~´......Phase 3A@..DWADWÙ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841574108415741084.DWAB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÙ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDéèHrÃ;èDW#DÚ4Hrá~´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDéèHrÃ;èDW#DÚ4Hrá~´......Phase 3A@..DWADWÙ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841575108415751084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW½DWA AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDî\HrÃ@\DW‡DåìHse`lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWrDW‡.DWqPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDî\HrÃ@\DW#Dõ Hráš DWrDëŒHsI¶ŒDW‡DåìHse`lPhase 3A@..DWA.12-15 YearsA YNN. DWpDWýDWýAðYEARSDSAC4591001C4591001 1084 10841575108415751084.DWAB6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW½DWA AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDî\HrÃ@\DW‡DåìHse`lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWrDW‡.DWqPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDî\HrÃ@\DW#Dõ Hráš DWrDëŒHsI¶ŒDW‡DåìHse`lPhase 3A@..DWA.12-15 YearsA YNN. DWpDWýDWýAðYEARSDSA C4591001C4591001 1084 10841575108415751084DWrDWrBgREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW½DWA AðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDî\HrÃ@\DW‡DåìHse`lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWrDW‡.DWqPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDî\HrÃ@\DW#Dõ Hráš DWrDëŒHsI¶ŒDW‡DåìHse`lPhase 3A@..DWA.12-15 YearsA YNN. DWpDWýDWýAðYEARSDSA0C4591001C4591001 1084 10841575108415751084.DW½B²OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW½DWAYAðYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWDî\HrÃ@\DW‡DåìHse`lPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DWrDW‡.DWqPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDî\HrÃ@\DW#Dõ Hráš DWrDëŒHsI¶ŒDW‡DåìHse`lPhase 3A@..DWA.12-15 YearsA YNN. DWpDWýDWýAðYEARSDSA@C4591001C4591001 1084 10841576108415761084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŒ(HrÅ(DW!D€¬HrÞ‚,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŒ(HrÅ(DW!D€¬HrÞ‚,......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW’DWýDWýAðYEARSDSAC4591001C4591001 1084 10841576108415761084.DW=B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=DWÐ.DW= AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŒ(HrÅ(DW!D€¬HrÞ‚,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŒ(HrÅ(DW!D€¬HrÞ‚,......Phase 3A@..DW=DWÐ12-15 YearsA YNY. DW’DWýDWýAðYEARSDSA C4591001C4591001 1084 10841577108415771084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD´´HrÅ©´DW¨DœHsŒœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW”DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´´HrÅ©´DW#Dß˜Hrá„DW”Då8Hsvƒ8DW¨DœHsŒœPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1084 10841577108415771084.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD´´HrÅ©´DW¨DœHsŒœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW”DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´´HrÅ©´DW#Dß˜Hrá„DW”Då8Hsvƒ8DW¨DœHsŒœPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1084 10841577108415771084DW”DW”B‡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW? AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD´´HrÅ©´DW¨DœHsŒœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW”DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´´HrÅ©´DW#Dß˜Hrá„DW”Då8Hsvƒ8DW¨DœHsŒœPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1084 10841577108415771084.DWÄB·OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÄDW?YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD´´HrÅ©´DW¨DœHsŒœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW”DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD´´HrÅ©´DW#Dß˜Hrá„DW”Då8Hsvƒ8DW¨DœHsŒœPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1084 10841578108415781084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÙ.DW? AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDµ,HrÅª,DW#DâàHrá‡`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDµ,HrÅª,DW#DâàHrá‡`......Phase 3A@..DW?DWÙ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1084 10841578108415781084.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÙ.DW? AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDµ,HrÅª,DW#DâàHrá‡`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDµ,HrÅª,DW#DâàHrá‡`......Phase 3A@..DW?DWÙ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1084 10841579108415791084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@..DW@ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈÜHrÅ½ÜDW#Dð<Hrá”¼Placebo Placebo 12-15 YearsA . . .DWDW#....DWPlacebo Placebo Placebo A .Placebo A .DWDÈÜHrÅ½ÜDW#Dð<Hrá”¼......Phase 3A@DW˜.DW@.12-15 YearsA YNN. DWŒDW˜DW˜AÐYEARSDSAC4591001C4591001 1084 10841579108415791084.DW@B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@..DW@ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈÜHrÅ½ÜDW#Dð<Hrá”¼Placebo Placebo 12-15 YearsA . . .DWDW#....DWPlacebo Placebo Placebo A .Placebo A .DWDÈÜHrÅ½ÜDW#Dð<Hrá”¼......Phase 3A@DW˜.DW@.12-15 YearsA YNN. DWŒDW˜DW˜AÐYEARSDSA C4591001C4591001 1084 10841579108415791084.DW˜B‹FOLLOW-UP BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABSubject received outside Pfizer Vaccine 14May2021 DW@..DW@YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÈÜHrÅ½ÜDW#Dð<Hrá”¼Placebo Placebo 12-15 YearsA . . .DWDW#....DWPlacebo Placebo Placebo A .Placebo A .DWDÈÜHrÅ½ÜDW#Dð<Hrá”¼......Phase 3A@DW˜.DW@.12-15 YearsA YNN. DWŒDW˜DW˜AÐYEARSDSAPC4591001C4591001 1084 10841580108415801084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÔ.DW@ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÉHrÅ¾DW#DòÐHrá—PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÉHrÅ¾DW#DòÐHrá—P......Phase 3A@..DW@DWÔ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841580108415801084.DW@B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÔ.DW@ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÉHrÅ¾DW#DòÐHrá—PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÉHrÅ¾DW#DòÐHrá—P......Phase 3A@..DW@DWÔ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841581108415811084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜPHrÅÑPDW¦DàˆHsŽ9ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜPHrÅÑPDW#DÔHráxœDW‘DªÜHsrT\DW¦DàˆHsŽ9ˆPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1084 10841581108415811084.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜPHrÅÑPDW¦DàˆHsŽ9ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜPHrÅÑPDW#DÔHráxœDW‘DªÜHsrT\DW¦DàˆHsŽ9ˆPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1084 10841581108415811084DW‘DW‘B„REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW? AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜPHrÅÑPDW¦DàˆHsŽ9ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜPHrÅÑPDW#DÔHráxœDW‘DªÜHsrT\DW¦DàˆHsŽ9ˆPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1084 10841581108415811084.DWÃB¶OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÃDW?YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÜPHrÅÑPDW¦DàˆHsŽ9ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÜPHrÅÑPDW#DÔHráxœDW‘DªÜHsrT\DW¦DàˆHsŽ9ˆPhase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1084 10841582108415821084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDß˜HrÅÔ˜DW#Dõ(Hrá™¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDß˜HrÅÔ˜DW#Dõ(Hrá™¨......Phase 3A@..DWADW×12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1084 10841582108415821084.DWAB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDß˜HrÅÔ˜DW#Dõ(Hrá™¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDß˜HrÅÔ˜DW#Dõ(Hrá™¨......Phase 3A@..DWADW×12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1084 10841583108415831084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWà.DWA AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD—¤HrÈ/¤DW#DëÈHráHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD—¤HrÈ/¤DW#DëÈHráH......Phase 3A@..DWADWà12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1084 10841583108415831084.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWà.DWA AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD—¤HrÈ/¤DW#DëÈHráHBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD—¤HrÈ/¤DW#DëÈHráH......Phase 3A@..DWADWà12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1084 10841584108415841084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŸ`HrÈ7`DW%DÉHräBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŸ`HrÈ7`DW%DÉHrä......Phase 3A@..DWDDW×12-15 YearsA YNY. DW”DWýDWýAàYEARSDSAC4591001C4591001 1084 10841584108415841084.DWDB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDW×.DWD AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDŸ`HrÈ7`DW%DÉHräBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDŸ`HrÈ7`DW%DÉHrä......Phase 3A@..DWDDW×12-15 YearsA YNY. DW”DWýDWýAàYEARSDSA C4591001C4591001 1084 10841586108415861084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬€HrÈD€DWªD€4Hs“4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬€HrÈD€DW%DŸ$Hrãæ¤DW”DÐÔHsvnÔDWªD€4Hs“4Phase 3A@..DWA.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1084 10841586108415861084.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬€HrÈD€DWªD€4Hs“4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬€HrÈD€DW%DŸ$Hrãæ¤DW”DÐÔHsvnÔDWªD€4Hs“4Phase 3A@..DWA.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1084 10841586108415861084DW”DW”B…REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬€HrÈD€DWªD€4Hs“4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬€HrÈD€DW%DŸ$Hrãæ¤DW”DÐÔHsvnÔDWªD€4Hs“4Phase 3A@..DWA.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1084 10841586108415861084.DWÄBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWAYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬€HrÈD€DWªD€4Hs“4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬€HrÈD€DW%DŸ$Hrãæ¤DW”DÐÔHsvnÔDWªD€4Hs“4Phase 3A@..DWA.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1084 10841587108415871084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD·HrÈODW¨D¬Hs‹¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD·HrÈODW%D„0HrãË°DW”DÏ¨Hsvm¨DW¨D¬Hs‹¬Phase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841587108415871084.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD·HrÈODW¨D¬Hs‹¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD·HrÈODW%D„0HrãË°DW”DÏ¨Hsvm¨DW¨D¬Hs‹¬Phase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841587108415871084DW”DW”B…REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD·HrÈODW¨D¬Hs‹¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD·HrÈODW%D„0HrãË°DW”DÏ¨Hsvm¨DW¨D¬Hs‹¬Phase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1084 10841587108415871084.DWÄBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWAYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD·HrÈODW¨D¬Hs‹¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW”DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD·HrÈODW%D„0HrãË°DW”DÏ¨Hsvm¨DW¨D¬Hs‹¬Phase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1084 10841588108415881084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÀ¨HrÈX¨DWªD–´Hs“5´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW•DWª.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÀ¨HrÈX¨DW#DÓ,Hráw¬DW•Dê$HswÙ¤DWªD–´Hs“5´Phase 3A@..DWA.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1084 10841588108415881084.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÀ¨HrÈX¨DWªD–´Hs“5´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW•DWª.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÀ¨HrÈX¨DW#DÓ,Hráw¬DW•Dê$HswÙ¤DWªD–´Hs“5´Phase 3A@..DWA.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1084 10841588108415881084DW•DW•B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÀ¨HrÈX¨DWªD–´Hs“5´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW•DWª.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÀ¨HrÈX¨DW#DÓ,Hráw¬DW•Dê$HswÙ¤DWªD–´Hs“5´Phase 3A@..DWA.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1084 10841588108415881084.DWÄBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÄDWAYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÀ¨HrÈX¨DWªD–´Hs“5´Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW•DWª.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÀ¨HrÈX¨DW#DÓ,Hráw¬DW•Dê$HswÙ¤DWªD–´Hs“5´Phase 3A@..DWA.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1084 10841589108415891084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¼pHrÈTpDW%DøHrãåxPlacebo Placebo 12-15 YearsA . . .DWDW%.....Placebo Placebo Placebo A .Placebo A .DWD¼pHrÈTpDW%DøHrãåx......Phase 3A@..DWADWÔ12-15 YearsA YNN. DWý.DWýAðYEARSDSAC4591001C4591001 1084 10841589108415891084.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¼pHrÈTpDW%DøHrãåxPlacebo Placebo 12-15 YearsA . . .DWDW%.....Placebo Placebo Placebo A .Placebo A .DWD¼pHrÈTpDW%DøHrãåx......Phase 3A@..DWADWÔ12-15 YearsA YNN. DWý.DWýAðYEARSDSA C4591001C4591001 1084 10841590108415901084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÄDWD AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒ´HrÈj´DW¦D‹tHsätPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒ´HrÈj´DW%D$Hrã×¤DW‘DºHsrdDW¦D‹tHsätPhase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1084 10841590108415901084.DWDB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÄDWD AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒ´HrÈj´DW¦D‹tHsätPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒ´HrÈj´DW%D$Hrã×¤DW‘DºHsrdDW¦D‹tHsätPhase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1084 10841590108415901084DW‘DW‘B‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÄDWD AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒ´HrÈj´DW¦D‹tHsätPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒ´HrÈj´DW%D$Hrã×¤DW‘DºHsrdDW¦D‹tHsätPhase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1084 10841590108415901084.DWÄBµOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWD.DWÄDWDYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÒ´HrÈj´DW¦D‹tHsätPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÒ´HrÈj´DW%D$Hrã×¤DW‘DºHsrdDW¦D‹tHsätPhase 3A@..DWD.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1084 10841591108415911084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÔ.DWD AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒHrÈjDW%DŒÜHrãÔ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒHrÈjDW%DŒÜHrãÔ\......Phase 3A@..DWDDWÔ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841591108415911084.DWDB5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDDWÔ.DWD AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÒHrÈjDW%DŒÜHrãÔ\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÒHrÈjDW%DŒÜHrãÔ\......Phase 3A@..DWDDWÔ12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841592108415921084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÛ.DWF AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDË¬HrÈc¬DW#DøHráBxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDË¬HrÈc¬DW#DøHráBx......Phase 3A@..DWFDWÛ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1084 10841592108415921084.DWFB7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWFDWÛ.DWF AàYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDË¬HrÈc¬DW#DøHráBxBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDË¬HrÈc¬DW#DøHráBx......Phase 3A@..DWFDWÛ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1084 10841593108415931084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙ¼HrÈq¼DW%D¦,Hrãí¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙ¼HrÈq¼DW%D¦,Hrãí¬......Phase 3A@..DWADWÔ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841593108415931084.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÔ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙ¼HrÈq¼DW%D¦,Hrãí¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙ¼HrÈq¼DW%D¦,Hrãí¬......Phase 3A@..DWADWÔ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841594108415941084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWÛ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDåìHrÈ}ìDW%D©tHrãðôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDåìHrÈ}ìDW%D©tHrãðô......Phase 3A@..DWADWÛ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1084 10841594108415941084.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWÛ.DWA AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDåìHrÈ}ìDW%D©tHrãðôBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDåìHrÈ}ìDW%D©tHrãðô......Phase 3A@..DWADWÛ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1084 10841595108415951084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÂDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDçÌHrÈÌDW¦DÑHsŽ*Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDçÌHrÈÌDW#Dì|HráüDW‘DêœHsr”DW¦DÑHsŽ*Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1084 10841595108415951084.DW?B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÂDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDçÌHrÈÌDW¦DÑHsŽ*Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDçÌHrÈÌDW#Dì|HráüDW‘DêœHsr”DW¦DÑHsŽ*Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1084 10841595108415951084DW‘DW‘B‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÂDW? AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDçÌHrÈÌDW¦DÑHsŽ*Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDçÌHrÈÌDW#Dì|HráüDW‘DêœHsr”DW¦DÑHsŽ*Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1084 10841595108415951084.DWÂB³OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWÂDW?YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDçÌHrÈÌDW¦DÑHsŽ*Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDçÌHrÈÌDW#Dì|HráüDW‘DêœHsr”DW¦DÑHsŽ*Phase 3A@..DW?.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1084 10841596108415961084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDé4HrÈ4DW¦D‰ÐHsâÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDé4HrÈ4DW%D°|Hrã÷üDW‘D¬øHsrVxDW¦D‰ÐHsâÐPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1084 10841596108415961084.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDé4HrÈ4DW¦D‰ÐHsâÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDé4HrÈ4DW%D°|Hrã÷üDW‘D¬øHsrVxDW¦D‰ÐHsâÐPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1084 10841596108415961084DW‘DW‘B‚REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWA AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDé4HrÈ4DW¦D‰ÐHsâÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDé4HrÈ4DW%D°|Hrã÷üDW‘D¬øHsrVxDW¦D‰ÐHsâÐPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1084 10841596108415961084.DWÃB´OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DWÃDWAYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDé4HrÈ4DW¦D‰ÐHsâÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDé4HrÈ4DW%D°|Hrã÷üDW‘D¬øHsrVxDW¦D‰ÐHsâÐPhase 3A@..DWA.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1084 10841597108415971084DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¼DWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDêØHrÈ‚ØDWœDÛ`Hs`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‡DWœ.DWwPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDêØHrÈ‚ØDW#Dä„Hrá‰DW‡DÈÜHseC\DWœDÛ`Hs`Phase 3A@..DWA.12-15 YearsA YNN. DWvDWýDWýAðYEARSDSAC4591001C4591001 1084 10841597108415971084.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¼DWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDêØHrÈ‚ØDWœDÛ`Hs`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‡DWœ.DWwPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDêØHrÈ‚ØDW#Dä„Hrá‰DW‡DÈÜHseC\DWœDÛ`Hs`Phase 3A@..DWA.12-15 YearsA YNN. DWvDWýDWýAðYEARSDSA C4591001C4591001 1084 10841597108415971084DW‡DW‡BxREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¼DWA AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDêØHrÈ‚ØDWœDÛ`Hs`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‡DWœ.DWwPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDêØHrÈ‚ØDW#Dä„Hrá‰DW‡DÈÜHseC\DWœDÛ`Hs`Phase 3A@..DWA.12-15 YearsA YNN. DWvDWýDWýAðYEARSDSA0C4591001C4591001 1084 10841597108415971084.DW¼BOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWA.DW¼DWAYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDêØHrÈ‚ØDWœDÛ`Hs`Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‡DWœ.DWwPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDêØHrÈ‚ØDW#Dä„Hrá‰DW‡DÈÜHseC\DWœDÛ`Hs`Phase 3A@..DWA.12-15 YearsA YNN. DWvDWýDWýAðYEARSDSA@C4591001C4591001 1091 10911394109113941091DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD½œHr—ŽDVþD³Hr°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DW;BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD½œHr—ŽDVþD³Hr°......Phase 3A@..DWDW°12-15 YearsAYYNY. DW:DWýDWýAðYEARSDSAC4591001C4591001 1091 10911394109113941091.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD½œHr—ŽDVþD³Hr°BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DW;BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD½œHr—ŽDVþD³Hr°......Phase 3A@..DWDW°12-15 YearsAYYNY. DW:DWýDWýAðYEARSDSA C4591001C4591001 1091 10911395109113951091DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD½$Hr—¤DVþD³ˆHr°ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD½$Hr—¤DVþD³ˆHr°ˆ......Phase 3A@..DWDW°12-15 YearsAYYNY. DW¯DWýDWýAàYEARSDSAC4591001C4591001 1091 10911395109113951091.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD½$Hr—¤DVþD³ˆHr°ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD½$Hr—¤DVþD³ˆHr°ˆ......Phase 3A@..DWDW°12-15 YearsAYYNY. DW¯DWýDWýAàYEARSDSA C4591001C4591001 1091 10911396109113961091DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¾DW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDäHHr—´ÈDW D›(Hs†(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DWŒDW .DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDäHHr—´ÈDVþDÚ4Hr°·4DWŒD„äHsk–äDW D›(Hs†(Phase 3A@..DW.12-15 YearsA YNN. DW…DWýDWýAðYEARSDSAC4591001C4591001 1091 10911396109113961091.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¾DW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDäHHr—´ÈDW D›(Hs†(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DWŒDW .DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDäHHr—´ÈDVþDÚ4Hr°·4DWŒD„äHsk–äDW D›(Hs†(Phase 3A@..DW.12-15 YearsA YNN. DW…DWýDWýAðYEARSDSA C4591001C4591001 1091 10911396109113961091DWŒDWŒB¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¾DW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDäHHr—´ÈDW D›(Hs†(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DWŒDW .DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDäHHr—´ÈDVþDÚ4Hr°·4DWŒD„äHsk–äDW D›(Hs†(Phase 3A@..DW.12-15 YearsA YNN. DW…DWýDWýAðYEARSDSA0C4591001C4591001 1091 10911396109113961091.DW¾BÔOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DW¾DWYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDäHHr—´ÈDW D›(Hs†(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DWŒDW .DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDäHHr—´ÈDVþDÚ4Hr°·4DWŒD„äHsk–äDW D›(Hs†(Phase 3A@..DW.12-15 YearsA YNN. DW…DWýDWýAðYEARSDSA@C4591001C4591001 1091 10911399109113991091DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÒ.DW+ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD™„Hrš DWDèHrÇ.ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD™„Hrš DWDèHrÇ.ˆ......Phase 3A@..DW+DWÒ12-15 YearsAYYNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1091 10911399109113991091.DW+B?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÒ.DW+ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD™„Hrš DWDèHrÇ.ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD™„Hrš DWDèHrÇ.ˆ......Phase 3A@..DW+DWÒ12-15 YearsAYYNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1091 10911400109114001091DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWôDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD ÈHršHDWÃDÙDHs´mÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW DWÃ.DW™Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD ÈHršHDWDÜPHr»EPDW DÒ<Hs†B<DWÃDÙDHs´mÄPhase 3A@..DW#.12-15 YearsAYYNN. DW˜DWýDWýAàYEARSDSAC4591001C4591001 1091 10911400109114001091.DW#B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWôDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD ÈHršHDWÃDÙDHs´mÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW DWÃ.DW™Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD ÈHršHDWDÜPHr»EPDW DÒ<Hs†B<DWÃDÙDHs´mÄPhase 3A@..DW#.12-15 YearsAYYNN. DW˜DWýDWýAàYEARSDSA C4591001C4591001 1091 10911400109114001091DW DW B´REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWôDW# AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD ÈHršHDWÃDÙDHs´mÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW DWÃ.DW™Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD ÈHršHDWDÜPHr»EPDW DÒ<Hs†B<DWÃDÙDHs´mÄPhase 3A@..DW#.12-15 YearsAYYNN. DW˜DWýDWýAàYEARSDSA0C4591001C4591001 1091 10911400109114001091.DWôC€OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWôDW#YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíD ÈHršHDWÃDÙDHs´mÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW DWÃ.DW™Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíD ÈHršHDWDÜPHr»EPDW DÒ<Hs†B<DWÃDÙDHs´mÄPhase 3A@..DW#.12-15 YearsAYYNN. DW˜DWýDWýAàYEARSDSA@C4591001C4591001 1091 10911402109114021091DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW½.DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDŽ€Hrö€DWD–HrºÿBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDŽ€Hrö€DWD–Hrºÿ......Phase 3A@..DW#DW½12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1091 10911402109114021091.DW#B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW½.DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDŽ€Hrö€DWD–HrºÿBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDŽ€Hrö€DWD–Hrºÿ......Phase 3A@..DW#DW½12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1091 10911403109114031091DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD£ÔHržÔDWD€4Hrºé4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD£ÔHržÔDWD€4Hrºé4......Phase 3A@..DW"DWµ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1091 10911403109114031091.DW"B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðD£ÔHržÔDWD€4Hrºé4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðD£ÔHržÔDWD€4Hrºé4......Phase 3A@..DW"DWµ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1091 10911404109114041091DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DWË.DW0 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¿ôHrž'ôDWD¨„Hr¹ÀPlacebo Placebo 12-15 YearsA . . .DVðDW....DWÃPlacebo Placebo Placebo A .Placebo A .DVðD¿ôHrž'ôDWD¨„Hr¹À......Phase 3A@..DW0DWË12-15 YearsA YNN. DWÂDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911404109114041091.DW0BAVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DWË.DW0 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD¿ôHrž'ôDWD¨„Hr¹ÀPlacebo Placebo 12-15 YearsA . . .DVðDW....DWÃPlacebo Placebo Placebo A .Placebo A .DVðD¿ôHrž'ôDWD¨„Hr¹À......Phase 3A@..DW0DWË12-15 YearsA YNN. DWÂDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911405109114051091DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÒDW$ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDß˜HržG˜DW¯D¬¼Hs™ã<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW›DW¯.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDß˜HržG˜DWD¨HHr¹¿ÈDW›D«THsƒÔDW¯D¬¼Hs™ã<Phase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1091 10911405109114051091.DW$B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÒDW$ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDß˜HržG˜DW¯D¬¼Hs™ã<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW›DW¯.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDß˜HržG˜DWD¨HHr¹¿ÈDW›D«THsƒÔDW¯D¬¼Hs™ã<Phase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1091 10911405109114051091DW›DW›B¬REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÒDW$ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDß˜HržG˜DW¯D¬¼Hs™ã<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW›DW¯.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDß˜HržG˜DWD¨HHr¹¿ÈDW›D«THsƒÔDW¯D¬¼Hs™ã<Phase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1091 10911405109114051091.DWÒBãOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW$.DWÒDW$YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðDß˜HržG˜DW¯D¬¼Hs™ã<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW›DW¯.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðDß˜HržG˜DWD¨HHr¹¿ÈDW›D«THsƒÔDW¯D¬¼Hs™ã<Phase 3A@..DW$.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1091 10911406109114061091DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW.DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDé¬HržQ¬DWD¢lHr¹¹ìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW®BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDé¬HržQ¬DWD¢lHr¹¹ì......Phase 3A@..DW!DW12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1091 10911406109114061091.DW!B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW.DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDé¬HržQ¬DWD¢lHr¹¹ìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW®BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDé¬HržQ¬DWD¢lHr¹¹ì......Phase 3A@..DW!DW12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1091 10911407109114071091DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¾DWûDW! AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDß\HrŸ˜ÜDWßD´HsÙ2€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWËDWß.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDß\HrŸ˜ÜDWDàLHr¹÷ÌDWËDÍÈHs¾îHDWßD´HsÙ2€Phase 3A@..DW!DW¾12-15 YearsAYYNN. DWÂDWýDWýAÀYEARSDSAC4591001C4591001 1091 10911407109114071091.DW!B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¾DWûDW! AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDß\HrŸ˜ÜDWßD´HsÙ2€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWËDWß.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDß\HrŸ˜ÜDWDàLHr¹÷ÌDWËDÍÈHs¾îHDWßD´HsÙ2€Phase 3A@..DW!DW¾12-15 YearsAYYNN. DWÂDWýDWýAÀYEARSDSA C4591001C4591001 1091 10911407109114071091DWËDWËBÛREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¾DWûDW! AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDß\HrŸ˜ÜDWßD´HsÙ2€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWËDWß.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDß\HrŸ˜ÜDWDàLHr¹÷ÌDWËDÍÈHs¾îHDWßD´HsÙ2€Phase 3A@..DW!DW¾12-15 YearsAYYNN. DWÂDWýDWýAÀYEARSDSA0C4591001C4591001 1091 10911407109114071091.DWûC°OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¾DWûDW!YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñDß\HrŸ˜ÜDWßD´HsÙ2€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DWËDWß.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñDß\HrŸ˜ÜDWDàLHr¹÷ÌDWËDÍÈHs¾îHDWßD´HsÙ2€Phase 3A@..DW!DW¾12-15 YearsAYYNN. DWÂDWýDWýAÀYEARSDSA@C4591001C4591001 1091 10911408109114081091DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW$DW».DW$ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDßÔHrŸ™TDWDÄhHr¼~èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWbBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDßÔHrŸ™TDWDÄhHr¼~è......Phase 3A@..DW$DW»12-15 YearsA YNY. DWaDWýDWýAðYEARSDSAC4591001C4591001 1091 10911408109114081091.DW$B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW$DW».DW$ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñDßÔHrŸ™TDWDÄhHr¼~èBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DWbBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñDßÔHrŸ™TDWDÄhHr¼~è......Phase 3A@..DW$DW»12-15 YearsA YNY. DWaDWýDWýAðYEARSDSA C4591001C4591001 1091 10911409109114091091DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(..DW( AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVòD–´Hr ¡´DWD‡Hr¹ž€Placebo Placebo 12-15 YearsA . . .DVòDW....DWPlacebo Placebo Placebo A .Placebo A .DVòD–´Hr ¡´DWD‡Hr¹ž€......Phase 3A@DWš.DW(.12-15 YearsA YNN. DWŒDWšDWšAàYEARSDSAC4591001C4591001 1091 10911409109114091091.DW(B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(..DW( AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVòD–´Hr ¡´DWD‡Hr¹ž€Placebo Placebo 12-15 YearsA . . .DVòDW....DWPlacebo Placebo Placebo A .Placebo A .DVòD–´Hr ¡´DWD‡Hr¹ž€......Phase 3A@DWš.DW(.12-15 YearsA YNN. DWŒDWšDWšAàYEARSDSA C4591001C4591001 1091 10911409109114091091.DWšB©FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY PARENT/GUARDIAN BWITHDRAWAL BY PARENT/GUARDIAN DW(..DW(YAàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVòD–´Hr ¡´DWD‡Hr¹ž€Placebo Placebo 12-15 YearsA . . .DVòDW....DWPlacebo Placebo Placebo A .Placebo A .DVòD–´Hr ¡´DWD‡Hr¹ž€......Phase 3A@DWš.DW(.12-15 YearsA YNN. DWŒDWšDWšAàYEARSDSA`C4591001C4591001 1091 10911410109114101091DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW·.DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD§XHr ²XDWD¡|Hr¹¸üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD§XHr ²XDWD¡|Hr¹¸ü......Phase 3A@..DW#DW·12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1091 10911410109114101091.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW·.DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD§XHr ²XDWD¡|Hr¹¸üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD§XHr ²XDWD¡|Hr¹¸ü......Phase 3A@..DW#DW·12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1091 10911411109114111091DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW×DW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¨HHr ³HDW·Dž¬Hs¤a,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW DW·.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¨HHr ³HDWD¡¸Hr¹¹8DW Dš°Hs† °DW·Dž¬Hs¤a,Phase 3A@..DW#.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1091 10911411109114111091.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW×DW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¨HHr ³HDW·Dž¬Hs¤a,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW DW·.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¨HHr ³HDWD¡¸Hr¹¹8DW Dš°Hs† °DW·Dž¬Hs¤a,Phase 3A@..DW#.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1091 10911411109114111091DW DW B¯REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW×DW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¨HHr ³HDW·Dž¬Hs¤a,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW DW·.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¨HHr ³HDWD¡¸Hr¹¹8DW Dš°Hs† °DW·Dž¬Hs¤a,Phase 3A@..DW#.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA0C4591001C4591001 1091 10911411109114111091.DW×BæOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DW×DW#YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD¨HHr ³HDW·Dž¬Hs¤a,Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DW DW·.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD¨HHr ³HDWD¡¸Hr¹¹8DW Dš°Hs† °DW·Dž¬Hs¤a,Phase 3A@..DW#.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA@C4591001C4591001 1091 10911412109114121091DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµ.DW# AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDäüHr ïüDWDÝôHr¼˜tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDäüHr ïüDWDÝôHr¼˜t......Phase 3A@..DW#DWµ12-15 YearsA YNY. DWµDWýDWýAðYEARSDSAC4591001C4591001 1091 10911412109114121091.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWµ.DW# AðYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDäüHr ïüDWDÝôHr¼˜tBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW¶BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDäüHr ïüDWDÝôHr¼˜t......Phase 3A@..DW#DWµ12-15 YearsA YNY. DWµDWýDWýAðYEARSDSA C4591001C4591001 1091 10911413109114131091DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DW¾.DW0 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDäHr ïDWD»€HrÇBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW˜BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDäHr ïDWD»€HrÇ......Phase 3A@..DW0DW¾12-15 YearsAYYNY. DW—DWýDWýAÀYEARSDSAC4591001C4591001 1091 10911413109114131091.DW0B?VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DW¾.DW0 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDäHr ïDWD»€HrÇBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW˜BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDäHr ïDWD»€HrÇ......Phase 3A@..DW0DW¾12-15 YearsAYYNY. DW—DWýDWýAÀYEARSDSA C4591001C4591001 1091 10911414109114141091DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0..DW0 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDä„Hr ï„DW™DôìHs}*lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVò.DW™...DW˜BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDä„Hr ï„DW™DôìHs}*l......Phase 3A@..DW0.12-15 YearsA YNN. DW—DWýDWýAàYEARSDSAC4591001C4591001 1091 10911414109114141091.DW¾BÍVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0..DW0 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDä„Hr ï„DW™DôìHs}*lBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVò.DW™...DW˜BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDä„Hr ï„DW™DôìHs}*l......Phase 3A@..DW0.12-15 YearsA YNN. DW—DWýDWýAàYEARSDSA C4591001C4591001 1091 10911415109114151091DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÓDW# AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVóD›dHr¡÷äDWµDÜPHs¡ûÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD›dHr¡÷äDWDÝ@Hr»F@DW DæÜHs†VÜDWµDÜPHs¡ûÐPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSAC4591001C4591001 1091 10911415109114151091.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÓDW# AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVóD›dHr¡÷äDWµDÜPHs¡ûÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD›dHr¡÷äDWDÝ@Hr»F@DW DæÜHs†VÜDWµDÜPHs¡ûÐPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA C4591001C4591001 1091 10911415109114151091DW DW B®REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÓDW# AðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVóD›dHr¡÷äDWµDÜPHs¡ûÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD›dHr¡÷äDWDÝ@Hr»F@DW DæÜHs†VÜDWµDÜPHs¡ûÐPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA0C4591001C4591001 1091 10911415109114151091.DWÓBáOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÓDW#YAðYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVóD›dHr¡÷äDWµDÜPHs¡ûÐPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD›dHr¡÷äDWDÝ@Hr»F@DW DæÜHs†VÜDWµDÜPHs¡ûÐPhase 3A@..DW#.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA@C4591001C4591001 1091 10911416109114161091DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DWÄ.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD´Hr¢€DWDÒðHr¼pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW}BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD´Hr¢€DWDÒðHr¼p......Phase 3A@..DW#DWÄ12-15 YearsAYYNY. DW|DWýDWýAðYEARSDSAC4591001C4591001 1091 10911416109114161091.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DWÄ.DW# AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóD´Hr¢€DWDÒðHr¼pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW}BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóD´Hr¢€DWDÒðHr¼p......Phase 3A@..DW#DWÄ12-15 YearsAYYNY. DW|DWýDWýAðYEARSDSA C4591001C4591001 1091 10911417109114171091DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWàDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD´<Hr¢¼DW¨DÃðHs¿ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD´<Hr¢¼DWDÒ<Hr¼Œ¼DW’DzÐHssuÐDW¨DÃðHs¿ðPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911417109114171091.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWàDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD´<Hr¢¼DW¨DÃðHs¿ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD´<Hr¢¼DWDÒ<Hr¼Œ¼DW’DzÐHssuÐDW¨DÃðHs¿ðPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911417109114171091DW‘DW‘BŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWàDW# AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD´<Hr¢¼DW¨DÃðHs¿ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD´<Hr¢¼DWDÒ<Hr¼Œ¼DW’DzÐHssuÐDW¨DÃðHs¿ðPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1091 10911417109114171091.DWàBîOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWàDW#YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóD´<Hr¢¼DW¨DÃðHs¿ðPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóD´<Hr¢¼DWDÒ<Hr¼Œ¼DW’DzÐHssuÐDW¨DÃðHs¿ðPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1091 10911418109114181091DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDª Hr¢ DW¦D¬HsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDª Hr¢ DWD°|Hr¼jüDW‘D÷DHsr ÄDW¦D¬HsŽPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1091 10911418109114181091.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDª Hr¢ DW¦D¬HsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDª Hr¢ DWD°|Hr¼jüDW‘D÷DHsr ÄDW¦D¬HsŽPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1091 10911418109114181091DW‘DW‘BŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDª Hr¢ DW¦D¬HsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDª Hr¢ DWD°|Hr¼jüDW‘D÷DHsr ÄDW¦D¬HsŽPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1091 10911418109114181091.DWÃBÑOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW#YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDª Hr¢ DW¦D¬HsŽPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDª Hr¢ DWD°|Hr¼jüDW‘D÷DHsr ÄDW¦D¬HsŽPhase 3A@..DW#.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1091 10911419109114191091DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÞlHr¢:ìDWD°¸Hr¼k8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÞlHr¢:ìDWD°¸Hr¼k8......Phase 3A@..DW#DW¶12-15 YearsA YNY. DW“DWýDWýAÐYEARSDSAC4591001C4591001 1091 10911419109114191091.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÞlHr¢:ìDWD°¸Hr¼k8BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÞlHr¢:ìDWD°¸Hr¼k8......Phase 3A@..DW#DW¶12-15 YearsA YNY. DW“DWýDWýAÐYEARSDSA C4591001C4591001 1091 10911420109114201091DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW».DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÝ|Hr¢9üDWDè¼Hr¼£<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÝ|Hr¢9üDWDè¼Hr¼£<......Phase 3A@..DW#DW»12-15 YearsAYYNY. DW“DWýDWýAÀYEARSDSAC4591001C4591001 1091 10911420109114201091.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW».DW# AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÝ|Hr¢9üDWDè¼Hr¼£<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW”BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÝ|Hr¢9üDWDè¼Hr¼£<......Phase 3A@..DW#DW»12-15 YearsAYYNY. DW“DWýDWýAÀYEARSDSA C4591001C4591001 1091 10911421109114211091DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÝ¸Hr¢:8DW§Då°Hs0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW§.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÝ¸Hr¢:8DWDé4Hr¼£´DW”Es@Hsv¥4DW§Då°Hs0Phase 3A@..DW#.12-15 YearsA YNN. DW“DWýDWýAðYEARSDSAC4591001C4591001 1091 10911421109114211091.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÝ¸Hr¢:8DW§Då°Hs0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW§.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÝ¸Hr¢:8DWDé4Hr¼£´DW”Es@Hsv¥4DW§Då°Hs0Phase 3A@..DW#.12-15 YearsA YNN. DW“DWýDWýAðYEARSDSA C4591001C4591001 1091 10911421109114211091DW”DW”B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÝ¸Hr¢:8DW§Då°Hs0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW§.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÝ¸Hr¢:8DWDé4Hr¼£´DW”Es@Hsv¥4DW§Då°Hs0Phase 3A@..DW#.12-15 YearsA YNN. DW“DWýDWýAðYEARSDSA0C4591001C4591001 1091 10911421109114211091.DWÃBÑOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW#.DWÃDW#YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVóDÝ¸Hr¢:8DW§Då°Hs0Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVóDW.DW”DW§.DW”Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVóDÝ¸Hr¢:8DWDé4Hr¼£´DW”Es@Hsv¥4DW§Då°Hs0Phase 3A@..DW#.12-15 YearsA YNN. DW“DWýDWýAðYEARSDSA@C4591001C4591001 1091 10911422109114221091DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÃ.DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D“äHr§6dDWDyhHrÅnhBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D“äHr§6dDWDyhHrÅnh......Phase 3A@..DW*DWÃ12-15 YearsA YNY. DW¯DWýDWýAðYEARSDSAC4591001C4591001 1091 10911422109114221091.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÃ.DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D“äHr§6dDWDyhHrÅnhBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DW°BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D“äHr§6dDWDyhHrÅnh......Phase 3A@..DW*DWÃ12-15 YearsA YNY. DW¯DWýDWýAðYEARSDSA C4591001C4591001 1091 10911423109114231091DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWóDW1 AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV÷D” Hr§6 DWÒDÜÈHsÈ7ÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW½DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D” Hr§6 DWD’|HrÅ‡|DW½DÏ¨Hs¬{(DWÒDÜÈHsÈ7ÈPhase 3A@..DW1.12-15 YearsA YNN. DW¶DWýDWýAàYEARSDSAC4591001C4591001 1091 10911423109114231091.DW1B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWóDW1 AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV÷D” Hr§6 DWÒDÜÈHsÈ7ÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW½DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D” Hr§6 DWD’|HrÅ‡|DW½DÏ¨Hs¬{(DWÒDÜÈHsÈ7ÈPhase 3A@..DW1.12-15 YearsA YNN. DW¶DWýDWýAàYEARSDSA C4591001C4591001 1091 10911423109114231091DW½DW½BÇREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWóDW1 AàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV÷D” Hr§6 DWÒDÜÈHsÈ7ÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW½DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D” Hr§6 DWD’|HrÅ‡|DW½DÏ¨Hs¬{(DWÒDÜÈHsÈ7ÈPhase 3A@..DW1.12-15 YearsA YNN. DW¶DWýDWýAàYEARSDSA0C4591001C4591001 1091 10911423109114231091.DWóBýOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWóDW1YAàYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DV÷D” Hr§6 DWÒDÜÈHsÈ7ÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW½DWÒ.DW·Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D” Hr§6 DWD’|HrÅ‡|DW½DÏ¨Hs¬{(DWÒDÜÈHsÈ7ÈPhase 3A@..DW1.12-15 YearsA YNN. DW¶DWýDWýAàYEARSDSA@C4591001C4591001 1091 10911424109114241091DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÄDW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD¡|Hr¨•|DW¦Dt|HsÍ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW“DW¦.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD¡|Hr¨•|DWDèHrÂáèDW“DzHstÆœDW¦Dt|HsÍ|Phase 3A@..DW(.12-15 YearsAYYNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1091 10911424109114241091.DW(B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÄDW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD¡|Hr¨•|DW¦Dt|HsÍ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW“DW¦.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD¡|Hr¨•|DWDèHrÂáèDW“DzHstÆœDW¦Dt|HsÍ|Phase 3A@..DW(.12-15 YearsAYYNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1091 10911424109114241091DW“DW“BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÄDW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD¡|Hr¨•|DW¦Dt|HsÍ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW“DW¦.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD¡|Hr¨•|DWDèHrÂáèDW“DzHstÆœDW¦Dt|HsÍ|Phase 3A@..DW(.12-15 YearsAYYNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1091 10911424109114241091.DWÄBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÄDW(YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD¡|Hr¨•|DW¦Dt|HsÍ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW“DW¦.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD¡|Hr¨•|DWDèHrÂáèDW“DzHstÆœDW¦Dt|HsÍ|Phase 3A@..DW(.12-15 YearsAYYNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1091 10911425109114251091DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÉDW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD°ôHr¨¤ôDWD¼Hs—1<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW˜DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD°ôHr¨¤ôDW D¬HrÄOˆDW˜DèøHs{ÌøDWD¼Hs—1<Phase 3A@..DW).12-15 YearsA YNN. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1091 10911425109114251091.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÉDW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD°ôHr¨¤ôDWD¼Hs—1<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW˜DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD°ôHr¨¤ôDW D¬HrÄOˆDW˜DèøHs{ÌøDWD¼Hs—1<Phase 3A@..DW).12-15 YearsA YNN. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1091 10911425109114251091DW˜DW˜B¡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÉDW) AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD°ôHr¨¤ôDWD¼Hs—1<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW˜DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD°ôHr¨¤ôDW D¬HrÄOˆDW˜DèøHs{ÌøDWD¼Hs—1<Phase 3A@..DW).12-15 YearsA YNN. DW’DWýDWýAÀYEARSDSA0C4591001C4591001 1091 10911425109114251091.DWÉBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÉDW)YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøD°ôHr¨¤ôDWD¼Hs—1<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW .DW˜DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøD°ôHr¨¤ôDW D¬HrÄOˆDW˜DèøHs{ÌøDWD¼Hs—1<Phase 3A@..DW).12-15 YearsA YNN. DW’DWýDWýAÀYEARSDSA@C4591001C4591001 1091 10911426109114261091DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD½`HrªàDWDÇ8HrÇ ¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD½`HrªàDWDÇ8HrÇ ¸......Phase 3A@..DW+DW¾12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911426109114261091.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD½`HrªàDWDÇ8HrÇ ¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD½`HrªàDWDÇ8HrÇ ¸......Phase 3A@..DW+DW¾12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911427109114271091DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÆ.DW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÎHrª„DWD¦¤HrÅ›¤Placebo Placebo 12-15 YearsA . . .DVùDW....DW’Placebo Placebo Placebo A .Placebo A .DVùDÎHrª„DWD¦¤HrÅ›¤......Phase 3A@..DW1DWÆ12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1091 10911427109114271091.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÆ.DW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÎHrª„DWD¦¤HrÅ›¤Placebo Placebo 12-15 YearsA . . .DVùDW....DW’Placebo Placebo Placebo A .Placebo A .DVùDÎHrª„DWD¦¤HrÅ›¤......Phase 3A@..DW1DWÆ12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1091 10911428109114281091DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DW½.DW1 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÎ|HrªüDWD¦,HrÅ›,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÎ|HrªüDWD¦,HrÅ›,......Phase 3A@..DW1DW½12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1091 10911428109114281091.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DW½.DW1 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÎ|HrªüDWD¦,HrÅ›,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÎ|HrªüDWD¦,HrÅ›,......Phase 3A@..DW1DW½12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1091 10911429109114291091DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW›DW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÙHrªˆDW}DèDHsX3ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWcDW}.DWbPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÙHrªˆDWDsHrÅhDWcD–Hs5š€DW}DèDHsX3ÄPhase 3A@..DW+.12-15 YearsA YNN. DWaDWýDWýAðYEARSDSAC4591001C4591001 1091 10911429109114291091.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW›DW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÙHrªˆDW}DèDHsX3ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWcDW}.DWbPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÙHrªˆDWDsHrÅhDWcD–Hs5š€DW}DèDHsX3ÄPhase 3A@..DW+.12-15 YearsA YNN. DWaDWýDWýAðYEARSDSA C4591001C4591001 1091 10911429109114291091DWcDWcBkREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW›DW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÙHrªˆDW}DèDHsX3ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWcDW}.DWbPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÙHrªˆDWDsHrÅhDWcD–Hs5š€DW}DèDHsX3ÄPhase 3A@..DW+.12-15 YearsA YNN. DWaDWýDWýAðYEARSDSA0C4591001C4591001 1091 10911429109114291091.DW›B£OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DW›DW+YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDÙHrªˆDW}DèDHsX3ÄPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWcDW}.DWbPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÙHrªˆDWDsHrÅhDWcD–Hs5š€DW}DèDHsX3ÄPhase 3A@..DW+.12-15 YearsA YNN. DWaDWýDWýAðYEARSDSA@C4591001C4591001 1091 10911430109114301091DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDàÄHrª&DDW¦D…\HsÞ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDàÄHrª&DDWDÉÌHrÃÌDW”Dý Hsv› DW¦D…\HsÞ\Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911430109114301091.DW)B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDàÄHrª&DDW¦D…\HsÞ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDàÄHrª&DDWDÉÌHrÃÌDW”Dý Hsv› DW¦D…\HsÞ\Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911430109114301091DW‘DW‘B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDàÄHrª&DDW¦D…\HsÞ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDàÄHrª&DDWDÉÌHrÃÌDW”Dý Hsv› DW¦D…\HsÞ\Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1091 10911430109114301091.DWÄBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÄDW)YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDàÄHrª&DDW¦D…\HsÞ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDàÄHrª&DDWDÉÌHrÃÌDW”Dý Hsv› DW¦D…\HsÞ\Phase 3A@..DW).12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1091 10911431109114311091DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DW¾.DW2 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD“lHr«*lDWDqpHrÍOpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD“lHr«*lDWDqpHrÍOp......Phase 3A@..DW2DW¾12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1091 10911431109114311091.DW2B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DW¾.DW2 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD“lHr«*lDWDqpHrÍOpBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD“lHr«*lDWDqpHrÍOp......Phase 3A@..DW2DW¾12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1091 10911432109114321091DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW©.DW) AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD’ôHr«)ôDWDÇìHrÅ¼ìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD’ôHr«)ôDWDÇìHrÅ¼ì......Phase 3A@..DW)DW©12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1091 10911432109114321091.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW©.DW) AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD’ôHr«)ôDWDÇìHrÅ¼ìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD’ôHr«)ôDWDÇìHrÅ¼ì......Phase 3A@..DW)DW©12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1091 10911433109114331091DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÙøHr«pøDWDè¼HrÇ/<Placebo Placebo 12-15 YearsA . . .DVúDW....DW™Placebo Placebo Placebo A .Placebo A .DVúDÙøHr«pøDWDè¼HrÇ/<......Phase 3A@..DW/.12-15 YearsA YNN. DW˜DWýDWýAàYEARSDSAC4591001C4591001 1091 10911433109114331091.DW/B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDÙøHr«pøDWDè¼HrÇ/<Placebo Placebo 12-15 YearsA . . .DVúDW....DW™Placebo Placebo Placebo A .Placebo A .DVúDÙøHr«pøDWDè¼HrÇ/<......Phase 3A@..DW/.12-15 YearsA YNN. DW˜DWýDWýAàYEARSDSA C4591001C4591001 1091 10911434109114341091DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÉDW+ AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÙ€Hr«p€DW©D`Hs‘ÝàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÙ€Hr«p€DWDºHrÇDW”Dš8Hsv88DW©D`Hs‘ÝàPhase 3A@..DW+.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1091 10911434109114341091.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÉDW+ AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÙ€Hr«p€DW©D`Hs‘ÝàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÙ€Hr«p€DWDºHrÇDW”Dš8Hsv88DW©D`Hs‘ÝàPhase 3A@..DW+.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1091 10911434109114341091DW”DW”B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÉDW+ AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÙ€Hr«p€DW©D`Hs‘ÝàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÙ€Hr«p€DWDºHrÇDW”Dš8Hsv88DW©D`Hs‘ÝàPhase 3A@..DW+.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1091 10911434109114341091.DWÉBÐOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÉDW+YAàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVúDÙ€Hr«p€DW©D`Hs‘ÝàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDÙ€Hr«p€DWDºHrÇDW”Dš8Hsv88DW©D`Hs‘ÝàPhase 3A@..DW+.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1091 10911435109114351091DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDì¸Hr«ƒ¸DWDëHrÇ1”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDì¸Hr«ƒ¸DWDëHrÇ1”......Phase 3A@..DW+DW¾12-15 YearsAYYNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1091 10911435109114351091.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW¾.DW+ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDì¸Hr«ƒ¸DWDëHrÇ1”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDì¸Hr«ƒ¸DWDëHrÇ1”......Phase 3A@..DW+DW¾12-15 YearsAYYNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1091 10911436109114361091DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW½.DW+ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDílHr«„lDWDˆ,HrÅ},BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDílHr«„lDWDˆ,HrÅ},......Phase 3A@..DW+DW½12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1091 10911436109114361091.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW½.DW+ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDílHr«„lDWDˆ,HrÅ},BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDílHr«„lDWDˆ,HrÅ},......Phase 3A@..DW+DW½12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1091 10911437109114371091DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWËDW+ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDí¨Hr«„¨DW®DãHs˜ÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWšDW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDí¨Hr«„¨DWDˆhHrÅ}hDWšDæ(Hs~m(DW®DãHs˜ÈPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911437109114371091.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWËDW+ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDí¨Hr«„¨DW®DãHs˜ÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWšDW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDí¨Hr«„¨DWDˆhHrÅ}hDWšDæ(Hs~m(DW®DãHs˜ÈPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911437109114371091DWšDWšB¡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWËDW+ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDí¨Hr«„¨DW®DãHs˜ÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWšDW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDí¨Hr«„¨DWDˆhHrÅ}hDWšDæ(Hs~m(DW®DãHs˜ÈPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1091 10911437109114371091.DWËBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWËDW+YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDí¨Hr«„¨DW®DãHs˜ÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DWšDW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDí¨Hr«„¨DWDˆhHrÅ}hDWšDæ(Hs~m(DW®DãHs˜ÈPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1091 10911438109114381091DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÃ.DW3 AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD–xHr¬~øDWDƒ¸HrÈ¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD–xHr¬~øDWDƒ¸HrÈ¸......Phase 3A@..DW3DWÃ12-15 YearsA YNY. DW”DWýDWýAÀYEARSDSAC4591001C4591001 1091 10911438109114381091.DW3B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÃ.DW3 AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD–xHr¬~øDWDƒ¸HrÈ¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD–xHr¬~øDWDƒ¸HrÈ¸......Phase 3A@..DW3DWÃ12-15 YearsA YNY. DW”DWýDWýAÀYEARSDSA C4591001C4591001 1091 10911439109114391091DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÒDW3 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD–ðHr¬pDW¶DÌœHs£=œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW¡DW¶.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD–ðHr¬pDWD„0HrÈ0DW¡DÈ Hs‡Š DW¶DÌœHs£=œPhase 3A@..DW3.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1091 10911439109114391091.DW3B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÒDW3 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD–ðHr¬pDW¶DÌœHs£=œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW¡DW¶.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD–ðHr¬pDWD„0HrÈ0DW¡DÈ Hs‡Š DW¶DÌœHs£=œPhase 3A@..DW3.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1091 10911439109114391091DW¡DW¡B§REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÒDW3 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD–ðHr¬pDW¶DÌœHs£=œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW¡DW¶.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD–ðHr¬pDWD„0HrÈ0DW¡DÈ Hs‡Š DW¶DÌœHs£=œPhase 3A@..DW3.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1091 10911439109114391091.DWÒBØOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW3.DWÒDW3YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD–ðHr¬pDW¶DÌœHs£=œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW¡DW¶.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD–ðHr¬pDWD„0HrÈ0DW¡DÈ Hs‡Š DW¶DÌœHs£=œPhase 3A@..DW3.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1091 10911440109114401091DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÃ.DW/ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD›ÜHr¬„\DWD†ÄHrÈÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD›ÜHr¬„\DWD†ÄHrÈÄ......Phase 3A@..DW/DWÃ12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911440109114401091.DW/B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÃ.DW/ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD›ÜHr¬„\DWD†ÄHrÈÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD›ÜHr¬„\DWD†ÄHrÈÄ......Phase 3A@..DW/DWÃ12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911441109114411091DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDœHr¬…DW§D{„Hs&Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDœHr¬…DWD‡<HrÈ<DW’D—àHss’àDW§D{„Hs&Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911441109114411091.DW/B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDœHr¬…DW§D{„Hs&Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDœHr¬…DWD‡<HrÈ<DW’D—àHss’àDW§D{„Hs&Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911441109114411091DW’DW’B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDœHr¬…DW§D{„Hs&Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDœHr¬…DWD‡<HrÈ<DW’D—àHss’àDW§D{„Hs&Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1091 10911442109114421091DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDHr¬…ˆDW§D{üHs&|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDHr¬…ˆDWD‡´HrÈ´DW’D˜Hss“DW§D{üHs&|Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1091 10911442109114421091.DW/B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDHr¬…ˆDW§D{üHs&|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDHr¬…ˆDWD‡´HrÈ´DW’D˜Hss“DW§D{üHs&|Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1091 10911442109114421091DW’DW’B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDHr¬…ˆDW§D{üHs&|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDHr¬…ˆDWD‡´HrÈ´DW’D˜Hss“DW§D{üHs&|Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1091 10911443109114431091DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWè.DW3 AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÖ8Hr°³8DWD¼HrÑR<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÖ8Hr°³8DWD¼HrÑR<......Phase 3A@..DW3DWè12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1091 10911443109114431091.DW3B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWè.DW3 AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÖ8Hr°³8DWD¼HrÑR<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÖ8Hr°³8DWD¼HrÑR<......Phase 3A@..DW3DWè12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1091 10911444109114441091DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÉ.DW/ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÐÔHr°ÔDWD‘PHrÌÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÐÔHr°ÔDWD‘PHrÌÐ......Phase 3A@..DW/DWÉ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1091 10911444109114441091.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÉ.DW/ AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÐÔHr°ÔDWD‘PHrÌÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÐÔHr°ÔDWD‘PHrÌÐ......Phase 3A@..DW/DWÉ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1091 10911445109114451091DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW= AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVþDÖ°Hr°³°DWDÕ„Hs—iPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW”DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÖ°Hr°³°DWDÇìHrÌTlDW”EzÀHsv¥¬DWDÕ„Hs—iPhase 3A@..DW=.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1091 10911445109114451091.DW=B@VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW= AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVþDÖ°Hr°³°DWDÕ„Hs—iPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW”DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÖ°Hr°³°DWDÇìHrÌTlDW”EzÀHsv¥¬DWDÕ„Hs—iPhase 3A@..DW=.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1091 10911445109114451091DW”DW”B—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW= AÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVþDÖ°Hr°³°DWDÕ„Hs—iPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW”DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÖ°Hr°³°DWDÇìHrÌTlDW”EzÀHsv¥¬DWDÕ„Hs—iPhase 3A@..DW=.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA0C4591001C4591001 1091 10911445109114451091.DWÉBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW=.DWÉDW=YAÐYEARSMAASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVþDÖ°Hr°³°DWDÕ„Hs—iPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW”DW.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÖ°Hr°³°DWDÇìHrÌTlDW”EzÀHsv¥¬DWDÕ„Hs—iPhase 3A@..DW=.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA@C4591001C4591001 1091 10911446109114461091DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD‡xHr±µøDWDxðHrÎ¨pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD‡xHr±µøDWDxðHrÎ¨p......Phase 3A@..DW1DWË12-15 YearsA YNY. DW”DWýDWýAÀYEARSDSAC4591001C4591001 1091 10911446109114461091.DW1B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWË.DW1 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD‡xHr±µøDWDxðHrÎ¨pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD‡xHr±µøDWDxðHrÎ¨p......Phase 3A@..DW1DWË12-15 YearsA YNY. DW”DWýDWýAÀYEARSDSA C4591001C4591001 1091 10911447109114471091DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÅ.DW6 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD–<Hr±Ä¼DWD ŒHrÐ!ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWTBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD–<Hr±Ä¼DWD ŒHrÐ!Œ......Phase 3A@..DW6DWÅ12-15 YearsA YNY. DWSDWýDWýAðYEARSDSAC4591001C4591001 1091 10911447109114471091.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÅ.DW6 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD–<Hr±Ä¼DWD ŒHrÐ!ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWTBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD–<Hr±Ä¼DWD ŒHrÐ!Œ......Phase 3A@..DW6DWÅ12-15 YearsA YNY. DWSDWýDWýAðYEARSDSA C4591001C4591001 1091 10911448109114481091DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÃDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD–xHr±ÄøDW¦DsŒHsÌŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD–xHr±ÄøDWD¯PHrÐ0PDW’DwLHssrLDW¦DsŒHsÌŒPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911448109114481091.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÃDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD–xHr±ÄøDW¦DsŒHsÌŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD–xHr±ÄøDWD¯PHrÐ0PDW’DwLHssrLDW¦DsŒHsÌŒPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911448109114481091DW‘DW‘B“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÃDW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD–xHr±ÄøDW¦DsŒHsÌŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD–xHr±ÄøDWD¯PHrÐ0PDW’DwLHssrLDW¦DsŒHsÌŒPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1091 10911448109114481091.DWÃBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÃDW6YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD–xHr±ÄøDW¦DsŒHsÌŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW’DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿD–xHr±ÄøDWD¯PHrÐ0PDW’DwLHssrLDW¦DsŒHsÌŒPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1091 10911449109114491091DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD¡|Hr±ÏüDWDÇtHrÌSôPlacebo Placebo 12-15 YearsA . . .DVÿDW....DWŽPlacebo Placebo Placebo A .Placebo A .DVÿD¡|Hr±ÏüDWDÇtHrÌSô......Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911449109114491091.DW/B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿD¡|Hr±ÏüDWDÇtHrÌSôPlacebo Placebo 12-15 YearsA . . .DVÿDW....DWŽPlacebo Placebo Placebo A .Placebo A .DVÿD¡|Hr±ÏüDWDÇtHrÌSô......Phase 3A@..DW/.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911450109114501091DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÄDW8 AÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿDØHr²˜DW¨D€èHs|èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW•DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDØHr²˜DWD}ÜHrÏþÜDW•D…ÔHswuTDW¨D€èHs|èPhase 3A@..DW8.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1091 10911450109114501091.DW8B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÄDW8 AÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿDØHr²˜DW¨D€èHs|èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW•DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDØHr²˜DWD}ÜHrÏþÜDW•D…ÔHswuTDW¨D€èHs|èPhase 3A@..DW8.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1091 10911450109114501091DW•DW•B—REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÄDW8 AÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿDØHr²˜DW¨D€èHs|èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW•DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDØHr²˜DWD}ÜHrÏþÜDW•D…ÔHswuTDW¨D€èHs|èPhase 3A@..DW8.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA0C4591001C4591001 1091 10911450109114501091.DWÄBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÄDW8YAÐYEARSMAMULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿDØHr²˜DW¨D€èHs|èPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW•DW¨.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDØHr²˜DWD}ÜHrÏþÜDW•D…ÔHswuTDW¨D€èHs|èPhase 3A@..DW8.12-15 YearsA YNN. DW‘DWýDWýAÐYEARSDSA@C4591001C4591001 1091 10911451109114511091DVÿDVÿ.SCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED .... AðYEARSMAWHITE AWHITE AYNBNT162b2 Phase 2/3 (30 mcg)B2_P23_30Not Treated NOTTRT ......BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . ........ . .BNT162b2 Phase 2/3 (30 mcg)A€ .............Phase 3A@DW...12-15 YearsA NN. DW.DWAðYEARSDSAC4591001C4591001 1091 10911451109114511091.DW.FOLLOW-UP BDISPOSITION EVENTOTHER ApSubject was rescreened under #1462. Subject randomized in error. .... AðYEARSMAWHITE AWHITE AYNBNT162b2 Phase 2/3 (30 mcg)B2_P23_30Not Treated NOTTRT ......BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . ........ . .BNT162b2 Phase 2/3 (30 mcg)A€ .............Phase 3A@DW...12-15 YearsA NN. DW.DWAðYEARSDSA0C4591001C4591001 1091 10911452109114521091DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÉDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDêœHr²DWD®$Hs—A¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDêœHr²DWDyhHrÎ¨èDW”DülHsvšlDWD®$Hs—A¤Phase 3A@..DW1.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1091 10911452109114521091.DW1B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÉDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDêœHr²DWD®$Hs—A¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDêœHr²DWDyhHrÎ¨èDW”DülHsvšlDWD®$Hs—A¤Phase 3A@..DW1.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1091 10911452109114521091DW”DW”B–REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÉDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDêœHr²DWD®$Hs—A¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDêœHr²DWDyhHrÎ¨èDW”DülHsvšlDWD®$Hs—A¤Phase 3A@..DW1.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1091 10911452109114521091.DWÉBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÉDW1YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDêœHr²DWD®$Hs—A¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW”DW.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDêœHr²DWDyhHrÎ¨èDW”DülHsvšlDWD®$Hs—A¤Phase 3A@..DW1.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1091 10911453109114531091DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÊ.DW8 AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDäHr²ŒDWDØHrÍnØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDäHr²ŒDWDØHrÍnØ......Phase 3A@..DW8DWÊ12-15 YearsA YNY. DW<DWýDWýAðYEARSDSAC4591001C4591001 1091 10911453109114531091.DW8B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÊ.DW8 AðYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDäHr²ŒDWDØHrÍnØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW=BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDäHr²ŒDWDØHrÍnØ......Phase 3A@..DW8DWÊ12-15 YearsA YNY. DW<DWýDWýAðYEARSDSA C4591001C4591001 1091 10911454109114541091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÒ.DW6 AàYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDßÔHr¹÷TDWD›ÜHrÕbÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWÒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDßÔHr¹÷TDWD›ÜHrÕbÜ......Phase 3A@..DW6DWÒ12-15 YearsA YNY. DWÑDWýDWýAàYEARSDSAC4591001C4591001 1091 10911454109114541091.DW6B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÒ.DW6 AàYEARSMAMULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDßÔHr¹÷TDWD›ÜHrÕbÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWÒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDßÔHr¹÷TDWD›ÜHrÕbÜ......Phase 3A@..DW6DWÒ12-15 YearsA YNY. DWÑDWýDWýAàYEARSDSA C4591001C4591001 1091 10911455109114551091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•ˆHrºþˆDWDœHrÖšPlacebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWD•ˆHrºþˆDWDœHrÖš......Phase 3A@..DWADW×12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1091 10911455109114551091.DWAB<VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADW×.DWA AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD•ˆHrºþˆDWDœHrÖšPlacebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWD•ˆHrºþˆDWDœHrÖš......Phase 3A@..DWADW×12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1091 10911456109114561091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÌ.DW6 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDí0Hr»V0DWDÍHrÕ”Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWDí0Hr»V0DWDÍHrÕ”......Phase 3A@..DW6DWÌ12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911456109114561091.DW6B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÌ.DW6 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDí0Hr»V0DWDÍHrÕ”Placebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWDí0Hr»V0DWDÍHrÕ”......Phase 3A@..DW6DWÌ12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911457109114571091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÌ.DW6 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDílHr»VlDWDÍŒHrÕ”ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDílHr»VlDWDÍŒHrÕ”Œ......Phase 3A@..DW6DWÌ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911457109114571091.DW6B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÌ.DW6 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDílHr»VlDWDÍŒHrÕ”ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDílHr»VlDWDÍŒHrÕ”Œ......Phase 3A@..DW6DWÌ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911458109114581091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÊ.DW9 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDì@Hr»U@DWD«ÌHrÖÄLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDì@Hr»U@DWD«ÌHrÖÄL......Phase 3A@..DW9DWÊ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1091 10911458109114581091.DW9B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÊ.DW9 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDì@Hr»U@DWD«ÌHrÖÄLBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDì@Hr»U@DWD«ÌHrÖÄL......Phase 3A@..DW9DWÊ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1091 10911459109114591091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÊDW9 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDì|Hr»U|DW©D“0Hs‘à°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDì|Hr»U|DWD¬DHrÖÄÄDW”DêœHsvˆœDW©D“0Hs‘à°Phase 3A@..DW9.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1091 10911459109114591091.DW9B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÊDW9 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDì|Hr»U|DW©D“0Hs‘à°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDì|Hr»U|DWD¬DHrÖÄÄDW”DêœHsvˆœDW©D“0Hs‘à°Phase 3A@..DW9.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1091 10911459109114591091DW”DW”BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÊDW9 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDì|Hr»U|DW©D“0Hs‘à°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDì|Hr»U|DWD¬DHrÖÄÄDW”DêœHsvˆœDW©D“0Hs‘à°Phase 3A@..DW9.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA0C4591001C4591001 1091 10911459109114591091.DWÊBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÊDW9YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDì|Hr»U|DW©D“0Hs‘à°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW”DW©.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDì|Hr»U|DWD¬DHrÖÄÄDW”DêœHsvˆœDW©D“0Hs‘à°Phase 3A@..DW9.12-15 YearsA YNN. DW‘DWýDWýAàYEARSDSA@C4591001C4591001 1091 10911460109114601091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÊ.DW8 AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¬DHr¼fÄDWDÈÜHrÖá\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¬DHr¼fÄDWDÈÜHrÖá\......Phase 3A@..DW8DWÊ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911460109114601091.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÊ.DW8 AÐYEARSFA BLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¬DHr¼fÄDWDÈÜHrÖá\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¬DHr¼fÄDWDÈÜHrÖá\......Phase 3A@..DW8DWÊ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911461109114611091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÊ.DW8 AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¬€Hr¼gDWDÉTHrÖáÔPlacebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWD¬€Hr¼gDWDÉTHrÖáÔ......Phase 3A@..DW8DWÊ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1091 10911461109114611091.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÊ.DW8 AàYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DWD¬€Hr¼gDWDÉTHrÖáÔPlacebo Placebo 12-15 YearsA . . .DWDW....DWPlacebo Placebo Placebo A .Placebo A .DWD¬€Hr¼gDWDÉTHrÖáÔ......Phase 3A@..DW8DWÊ12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1091 10911462109114621091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWØ.DW? AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡¸HrÂó¸DW#DžèHráChBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡¸HrÂó¸DW#DžèHráCh......Phase 3A@..DW?DWØ12-15 YearsA YNY. DW”DWýDWýAðYEARSDSAC4591001C4591001 1091 10911462109114621091.DW?B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWØ.DW? AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡¸HrÂó¸DW#DžèHráChBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW•BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡¸HrÂó¸DW#DžèHráCh......Phase 3A@..DW?DWØ12-15 YearsA YNY. DW”DWýDWýAðYEARSDSA C4591001C4591001 1091 10911463109114631091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDé4HrÃ;4DW¦D„äHsÝäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDé4HrÃ;4DW#DÜPHrá€ÐDW‘D÷¼Hsr¡<DW¦D„äHsÝäPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1091 10911463109114631091.DW@B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDé4HrÃ;4DW¦D„äHsÝäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDé4HrÃ;4DW#DÜPHrá€ÐDW‘D÷¼Hsr¡<DW¦D„äHsÝäPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1091 10911463109114631091DW‘DW‘B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDé4HrÃ;4DW¦D„äHsÝäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDé4HrÃ;4DW#DÜPHrá€ÐDW‘D÷¼Hsr¡<DW¦D„äHsÝäPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1091 10911463109114631091.DWÄB¹OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDé4HrÃ;4DW¦D„äHsÝäPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDé4HrÃ;4DW#DÜPHrá€ÐDW‘D÷¼Hsr¡<DW¦D„äHsÝäPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1091 10911464109114641091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÚ.DW@ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDé¬HrÃ;¬DW#DÜŒHráBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDé¬HrÃ;¬DW#DÜŒHrá......Phase 3A@..DW@DWÚ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911464109114641091.DW@B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÚ.DW@ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDé¬HrÃ;¬DW#DÜŒHráBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDé¬HrÃ;¬DW#DÜŒHrá......Phase 3A@..DW@DWÚ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911465109114651091DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D¢0HrÄE°DW#D’|Hrá6üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D¢0HrÄE°DW#D’|Hrá6ü......Phase 3A@..DW?DWÞ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSAC4591001C4591001 1091 10911465109114651091.DW?B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÞ.DW? AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW D¢0HrÄE°DW#D’|Hrá6üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW#....DWŒBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW D¢0HrÄE°DW#D’|Hrá6ü......Phase 3A@..DW?DWÞ12-15 YearsA YNY. DW‹DWýDWýAðYEARSDSA C4591001C4591001 1091 10911466109114661091DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWK.DWÑDWK AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD×dHrÌcäDW¦DÛØHsŽ4ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD×dHrÌcäDW)DèHréuˆDW’Dð<Hssë<DW¦DÛØHsŽ4ØPhase 3A@..DWK.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1091 10911466109114661091.DWKB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWK.DWÑDWK AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD×dHrÌcäDW¦DÛØHsŽ4ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD×dHrÌcäDW)DèHréuˆDW’Dð<Hssë<DW¦DÛØHsŽ4ØPhase 3A@..DWK.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1091 10911466109114661091DW‘DW‘BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWK.DWÑDWK AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD×dHrÌcäDW¦DÛØHsŽ4ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD×dHrÌcäDW)DèHréuˆDW’Dð<Hssë<DW¦DÛØHsŽ4ØPhase 3A@..DWK.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1091 10911466109114661091.DWÑB¿OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWK.DWÑDWKYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD×dHrÌcäDW¦DÛØHsŽ4ØPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW).DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD×dHrÌcäDW)DèHréuˆDW’Dð<Hssë<DW¦DÛØHsŽ4ØPhase 3A@..DWK.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231422112314221123DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDˆàHr–àDVþDˆàHr°eàPlacebo Placebo 12-15 YearsA . . .DVêDVþ....DW‘Placebo Placebo Placebo A .Placebo A .DVêDˆàHr–àDVþDˆàHr°eà......Phase 3A@DW¨.DW.12-15 YearsA YNN. DWDW¨DW¨AðYEARSDSAC4591001C4591001 1123 11231422112314221123.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW..DW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDˆàHr–àDVþDˆàHr°eàPlacebo Placebo 12-15 YearsA . . .DVêDVþ....DW‘Placebo Placebo Placebo A .Placebo A .DVêDˆàHr–àDVþDˆàHr°eà......Phase 3A@DW¨.DW.12-15 YearsA YNN. DWDW¨DW¨AðYEARSDSA C4591001C4591001 1123 11231422112314221123.DW¨B¿FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BPatient moved from the area and cannot be present for scheduled visits DW..DWYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDˆàHr–àDVþDˆàHr°eàPlacebo Placebo 12-15 YearsA . . .DVêDVþ....DW‘Placebo Placebo Placebo A .Placebo A .DVêDˆàHr–àDVþDˆàHr°eà......Phase 3A@DW¨.DW.12-15 YearsA YNN. DWDW¨DW¨AðYEARSDSApC4591001C4591001 1123 11231425112314251123DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD‡xHr—WøDVþD‚ŒHr°_ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD‡xHr—WøDVþD‚ŒHr°_Œ......Phase 3A@..DWDW°12-15 YearsA YNY. DW’DWýDWýAàYEARSDSAC4591001C4591001 1123 11231425112314251123.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW°.DW AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD‡xHr—WøDVþD‚ŒHr°_ŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD‡xHr—WøDVþD‚ŒHr°_Œ......Phase 3A@..DWDW°12-15 YearsA YNY. DW’DWýDWýAàYEARSDSA C4591001C4591001 1123 11231428112314281123DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDÕHHr˜÷HDVÿDƒHr±±„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDÕHHr˜÷HDVÿDƒHr±±„......Phase 3A@..DWDW®12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231428112314281123.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW®.DW AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDÕHHr˜÷HDVÿDƒHr±±„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDÕHHr˜÷HDVÿDƒHr±±„......Phase 3A@..DWDW®12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231431112314311123DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÄDW! AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDˆ,Hr™û¬DW¦DHsæPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDˆ,Hr™û¬DWD¨„Hr³(„DW’DépHssäpDW¦DHsæPhase 3A@..DW!.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231431112314311123.DW!B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÄDW! AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDˆ,Hr™û¬DW¦DHsæPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDˆ,Hr™û¬DWD¨„Hr³(„DW’DépHssäpDW¦DHsæPhase 3A@..DW!.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231431112314311123DW’DW’B¦REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÄDW! AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDˆ,Hr™û¬DW¦DHsæPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDˆ,Hr™û¬DWD¨„Hr³(„DW’DépHssäpDW¦DHsæPhase 3A@..DW!.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231431112314311123.DWÄBØOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW!.DWÄDW!YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDˆ,Hr™û¬DW¦DHsæPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDˆ,Hr™û¬DWD¨„Hr³(„DW’DépHssäpDW¦DHsæPhase 3A@..DW!.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231432112314321123DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW±.DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD‡´Hr™û4DWD¨ÀHr³(ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD‡´Hr™û4DWD¨ÀHr³(À......Phase 3A@..DW!DW±12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1123 11231432112314321123.DW!B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW±.DW! AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíD‡´Hr™û4DWD¨ÀHr³(ÀBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíD‡´Hr™û4DWD¨ÀHr³(À......Phase 3A@..DW!DW±12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1123 11231434112314341123DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%..DW% AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD$Hrø$DWD‚ÈHr¹šHPlacebo Placebo 12-15 YearsA . . .DVðDW....DWPlacebo Placebo Placebo A .Placebo A .DVðD$Hrø$DWD‚ÈHr¹šH......Phase 3A@DW.DW%.12-15 YearsA YNN. DWŒDWDWAÀYEARSDSAC4591001C4591001 1123 11231434112314341123.DW%B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%..DW% AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD$Hrø$DWD‚ÈHr¹šHPlacebo Placebo 12-15 YearsA . . .DVðDW....DWPlacebo Placebo Placebo A .Placebo A .DVðD$Hrø$DWD‚ÈHr¹šH......Phase 3A@DW.DW%.12-15 YearsA YNN. DWŒDWDWAÀYEARSDSA C4591001C4591001 1123 11231434112314341123.DWBžFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BPt requested to be dropped from the study and refused to elaborate DW%..DW%YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD$Hrø$DWD‚ÈHr¹šHPlacebo Placebo 12-15 YearsA . . .DVðDW....DWPlacebo Placebo Placebo A .Placebo A .DVðD$Hrø$DWD‚ÈHr¹šH......Phase 3A@DW.DW%.12-15 YearsA YNN. DWŒDWDWAÀYEARSDSA`C4591001C4591001 1123 11231438112314381123DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AàYEARSFA AMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYPlacebo PLACEBO Placebo PLACEBO DVñD”\HrŸMÜDWDŽ€HrÅƒ€Placebo Placebo 12-15 YearsA . . .DVñDW....DW“Placebo Placebo Placebo A .Placebo A .DVñD”\HrŸMÜDWDŽ€HrÅƒ€......Phase 3A@DW®.DW+.12-15 YearsAYYNN. DW’DW®DW®AàYEARSDSAC4591001C4591001 1123 11231438112314381123.DW+B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AàYEARSFA AMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYPlacebo PLACEBO Placebo PLACEBO DVñD”\HrŸMÜDWDŽ€HrÅƒ€Placebo Placebo 12-15 YearsA . . .DVñDW....DW“Placebo Placebo Placebo A .Placebo A .DVñD”\HrŸMÜDWDŽ€HrÅƒ€......Phase 3A@DW®.DW+.12-15 YearsAYYNN. DW’DW®DW®AàYEARSDSA C4591001C4591001 1123 11231438112314381123.DW®B¾FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APCould not reach patient via telephone to schedule vaccination DW+..DW+YAàYEARSFA AMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYPlacebo PLACEBO Placebo PLACEBO DVñD”\HrŸMÜDWDŽ€HrÅƒ€Placebo Placebo 12-15 YearsA . . .DVñDW....DW“Placebo Placebo Placebo A .Placebo A .DVñD”\HrŸMÜDWDŽ€HrÅƒ€......Phase 3A@DW®.DW+.12-15 YearsAYYNN. DW’DW®DW®AàYEARSDSAPC4591001C4591001 1123 11231439112314391123DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÄ.DW+ AÀYEARSFA AMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD“äHrŸMdDWD’HrÅ‡BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD“äHrŸMdDWD’HrÅ‡......Phase 3A@..DW+DWÄ12-15 YearsAYYNY. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231439112314391123.DW+B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÄ.DW+ AÀYEARSFA AMERICAN INDIAN OR ALASKA NATIVE A0AMERICAN INDIAN OR ALASKA NATIVE A0YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVñD“äHrŸMdDWD’HrÅ‡BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVñDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVñD“äHrŸMdDWD’HrÅ‡......Phase 3A@..DW+DWÄ12-15 YearsAYYNY. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231440112314401123DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DWµ.DW! AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD‡xHr ’xDWD‚PHr¹™ÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD‡xHr ’xDWD‚PHr¹™Ð......Phase 3A@..DW!DWµ12-15 YearsAYYNY. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1123 11231440112314401123.DW!B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DWµ.DW! AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD‡xHr ’xDWD‚PHr¹™ÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD‡xHr ’xDWD‚PHr¹™Ð......Phase 3A@..DW!DWµ12-15 YearsAYYNY. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1123 11231441112314411123DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,..DW, AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVòD¨HHr ³HDWDÇ°HrÃ°Placebo Placebo 12-15 YearsA . . .DVòDW.....Placebo Placebo Placebo A .Placebo A .DVòD¨HHr ³HDWDÇ°HrÃ°......Phase 3A@DWŠ.DW,.12-15 YearsAYYNN. DWŠ.DWŠAàYEARSDSAC4591001C4591001 1123 11231441112314411123.DW,B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,..DW, AàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVòD¨HHr ³HDWDÇ°HrÃ°Placebo Placebo 12-15 YearsA . . .DVòDW.....Placebo Placebo Placebo A .Placebo A .DVòD¨HHr ³HDWDÇ°HrÃ°......Phase 3A@DWŠ.DW,.12-15 YearsAYYNN. DWŠ.DWŠAàYEARSDSA C4591001C4591001 1123 11231441112314411123.DWŠB™FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APPatient lost to follow up due to inability to be present for appointments. DW,..DW,YAàYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVòD¨HHr ³HDWDÇ°HrÃ°Placebo Placebo 12-15 YearsA . . .DVòDW.....Placebo Placebo Placebo A .Placebo A .DVòD¨HHr ³HDWDÇ°HrÃ°......Phase 3A@DWŠ.DW,.12-15 YearsAYYNN. DWŠ.DWŠAàYEARSDSA@C4591001C4591001 1123 11231442112314421123DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÔDW( AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD°|Hr »|DWµDÃHs¡â€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDWµ.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD°|Hr »|DWDÂHrÃDWšDÒðHs~YðDWµDÃHs¡â€Phase 3A@..DW(.12-15 YearsA YNN. DW™DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231442112314421123.DW(B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÔDW( AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD°|Hr »|DWµDÃHs¡â€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDWµ.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD°|Hr »|DWDÂHrÃDWšDÒðHs~YðDWµDÃHs¡â€Phase 3A@..DW(.12-15 YearsA YNN. DW™DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231442112314421123DWšDWšB©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÔDW( AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD°|Hr »|DWµDÃHs¡â€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDWµ.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD°|Hr »|DWDÂHrÃDWšDÒðHs~YðDWµDÃHs¡â€Phase 3A@..DW(.12-15 YearsA YNN. DW™DWýDWýAÀYEARSDSA0C4591001C4591001 1123 11231442112314421123.DWÔBãOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÔDW(YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòD°|Hr »|DWµDÃHs¡â€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVòDW.DWšDWµ.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVòD°|Hr »|DWDÂHrÃDWšDÒðHs~YðDWµDÃHs¡â€Phase 3A@..DW(.12-15 YearsA YNN. DW™DWýDWýAÀYEARSDSA@C4591001C4591001 1123 11231443112314431123DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(..DW( AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD°Hr »DWDÂÄHrÃÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD°Hr »DWDÂÄHrÃÄ......Phase 3A@DWÃ.DW(.12-15 YearsA YNY. DWDWÃDWÃAàYEARSDSAC4591001C4591001 1123 11231443112314431123.DW(B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(..DW( AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD°Hr »DWDÂÄHrÃÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD°Hr »DWDÂÄHrÃÄ......Phase 3A@DWÃ.DW(.12-15 YearsA YNY. DWDWÃDWÃAàYEARSDSA C4591001C4591001 1123 11231443112314431123.DWÃBÒFOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APSubject no-showed for V4, and site staff was unable to contact them to reschedule DW(..DW(YAàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòD°Hr »DWDÂÄHrÃÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòD°Hr »DWDÂÄHrÃÄ......Phase 3A@DWÃ.DW(.12-15 YearsA YNY. DWDWÃDWÃAàYEARSDSAPC4591001C4591001 1123 11231445112314451123DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#..DW# AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÍHr ØDWDÙøHr¼”xPlacebo Placebo 12-15 YearsA . . .DVòDW....DW’Placebo Placebo Placebo A .Placebo A .DVòDÍHr ØDWDÙøHr¼”x......Phase 3A@DW©.DW#.12-15 YearsA YNN. DW‘DW©DW©AÀYEARSDSAC4591001C4591001 1123 11231445112314451123.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#..DW# AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÍHr ØDWDÙøHr¼”xPlacebo Placebo 12-15 YearsA . . .DVòDW....DW’Placebo Placebo Placebo A .Placebo A .DVòDÍHr ØDWDÙøHr¼”x......Phase 3A@DW©.DW#.12-15 YearsA YNN. DW‘DW©DW©AÀYEARSDSA C4591001C4591001 1123 11231445112314451123.DW©B¸FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BPatient requested to be out of the study, did not want to participate in crossover. DW#..DW#YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVòDÍHr ØDWDÙøHr¼”xPlacebo Placebo 12-15 YearsA . . .DVòDW....DW’Placebo Placebo Placebo A .Placebo A .DVòDÍHr ØDWDÙøHr¼”x......Phase 3A@DW©.DW#.12-15 YearsA YNN. DW‘DW©DW©AÀYEARSDSApC4591001C4591001 1123 11231446112314461123DVòDVòASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#..DW# AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÑÄHr ÜÄDWDÚpHr¼”ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW6BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÑÄHr ÜÄDWDÚpHr¼”ð......Phase 3A@DW½.DW#.12-15 YearsAYYNY. DW5DW½DW½AàYEARSDSAC4591001C4591001 1123 11231446112314461123.DW#B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#..DW# AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÑÄHr ÜÄDWDÚpHr¼”ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW6BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÑÄHr ÜÄDWDÚpHr¼”ð......Phase 3A@DW½.DW#.12-15 YearsAYYNY. DW5DW½DW½AàYEARSDSA C4591001C4591001 1123 11231446112314461123.DW½BÌFOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APSubject no showed for V4, staff could not contact subject DW#..DW#YAàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVòDÑÄHr ÜÄDWDÚpHr¼”ðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVòDW....DW6BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVòDÑÄHr ÜÄDWDÚpHr¼”ð......Phase 3A@DW½.DW#.12-15 YearsAYYNY. DW5DW½DW½AàYEARSDSA@C4591001C4591001 1123 11231447112314471123DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DW½.DW( AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÕüHr¢2|DWD–´Hrºÿ´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÕüHr¢2|DWD–´Hrºÿ´......Phase 3A@..DW(DW½12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1123 11231447112314471123.DW(B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DW½.DW( AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDÕüHr¢2|DWD–´Hrºÿ´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDÕüHr¢2|DWD–´Hrºÿ´......Phase 3A@..DW(DW½12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1123 11231448112314481123DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*..DW* AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD¼Hr£-¼DWD„0Hr¼>°Placebo Placebo 12-15 YearsA . . .DVôDW.....Placebo Placebo Placebo A .Placebo A .DVôD¼Hr£-¼DWD„0Hr¼>°......Phase 3A@DWv.DW*.12-15 YearsAYYNN. DWv.DWvAÐYEARSDSAC4591001C4591001 1123 11231448112314481123.DW*B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*..DW* AÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD¼Hr£-¼DWD„0Hr¼>°Placebo Placebo 12-15 YearsA . . .DVôDW.....Placebo Placebo Placebo A .Placebo A .DVôD¼Hr£-¼DWD„0Hr¼>°......Phase 3A@DWv.DW*.12-15 YearsAYYNN. DWv.DWvAÐYEARSDSA C4591001C4591001 1123 11231448112314481123.DWvBƒFOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APInability to contact patient regarding reported symptoms on illness diary DW*..DW*YAÐYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD¼Hr£-¼DWD„0Hr¼>°Placebo Placebo 12-15 YearsA . . .DVôDW.....Placebo Placebo Placebo A .Placebo A .DVôD¼Hr£-¼DWD„0Hr¼>°......Phase 3A@DWv.DW*.12-15 YearsAYYNN. DWv.DWvAÐYEARSDSAPC4591001C4591001 1123 11231449112314491123DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¶.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDèHr£=èDWDædHr¼ äBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDèHr£=èDWDædHr¼ ä......Phase 3A@..DW%DW¶12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1123 11231449112314491123.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%DW¶.DW% AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVôDèHr£=èDWDædHr¼ äBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVôDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVôDèHr£=èDWDædHr¼ ä......Phase 3A@..DW%DW¶12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1123 11231450112314501123DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWËDW% AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD–´Hr£D´DW¯Dƒ|Hs™¹üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWšDW¯.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD–´Hr£D´DWDÄ¤Hr¼$DWšDÝ|Hs~d|DW¯Dƒ|Hs™¹üPhase 3A@..DW%.12-15 YearsA YNN. DW™DWýDWýAðYEARSDSAC4591001C4591001 1123 11231450112314501123.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWËDW% AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD–´Hr£D´DW¯Dƒ|Hs™¹üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWšDW¯.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD–´Hr£D´DWDÄ¤Hr¼$DWšDÝ|Hs~d|DW¯Dƒ|Hs™¹üPhase 3A@..DW%.12-15 YearsA YNN. DW™DWýDWýAðYEARSDSA C4591001C4591001 1123 11231450112314501123DWšDWšB§REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWËDW% AðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD–´Hr£D´DW¯Dƒ|Hs™¹üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWšDW¯.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD–´Hr£D´DWDÄ¤Hr¼$DWšDÝ|Hs~d|DW¯Dƒ|Hs™¹üPhase 3A@..DW%.12-15 YearsA YNN. DW™DWýDWýAðYEARSDSA0C4591001C4591001 1123 11231450112314501123.DWËBØOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWËDW%YAðYEARSMABLACK OR AFRICAN AMERICAN A BLACK OR AFRICAN AMERICAN A YYPlacebo PLACEBO Placebo PLACEBO DVôD–´Hr£D´DW¯Dƒ|Hs™¹üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DWšDW¯.DWšPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôD–´Hr£D´DWDÄ¤Hr¼$DWšDÝ|Hs~d|DW¯Dƒ|Hs™¹üPhase 3A@..DW%.12-15 YearsA YNN. DW™DWýDWýAðYEARSDSA@C4591001C4591001 1123 11231451112314511123DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DW».DW+ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD‰Hr¨}DWDäüHrÃ6üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD‰Hr¨}DWDäüHrÃ6ü......Phase 3A@..DW+DW»12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231451112314511123.DW+B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DW».DW+ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD‰Hr¨}DWDäüHrÃ6üBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD‰Hr¨}DWDäüHrÃ6ü......Phase 3A@..DW+DW»12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231452112314521123DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW½DW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÒxHr¨ÆxDWšDÆÀHs~MÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW‡DWš.DW„Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÒxHr¨ÆxDWDƒ¸HrÂÕ¸DW‡D£\HseÜDWšDÆÀHs~MÀPhase 3A@..DW(.12-15 YearsA YNN. DWƒDWýDWýAðYEARSDSAC4591001C4591001 1123 11231452112314521123.DW(B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW½DW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÒxHr¨ÆxDWšDÆÀHs~MÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW‡DWš.DW„Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÒxHr¨ÆxDWDƒ¸HrÂÕ¸DW‡D£\HseÜDWšDÆÀHs~MÀPhase 3A@..DW(.12-15 YearsA YNN. DWƒDWýDWýAðYEARSDSA C4591001C4591001 1123 11231452112314521123DW‡DW‡BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW½DW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÒxHr¨ÆxDWšDÆÀHs~MÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW‡DWš.DW„Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÒxHr¨ÆxDWDƒ¸HrÂÕ¸DW‡D£\HseÜDWšDÆÀHs~MÀPhase 3A@..DW(.12-15 YearsA YNN. DWƒDWýDWýAðYEARSDSA0C4591001C4591001 1123 11231452112314521123.DW½BÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW½DW(YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÒxHr¨ÆxDWšDÆÀHs~MÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW‡DWš.DW„Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÒxHr¨ÆxDWDƒ¸HrÂÕ¸DW‡D£\HseÜDWšDÆÀHs~MÀPhase 3A@..DW(.12-15 YearsA YNN. DWƒDWýDWýAðYEARSDSA@C4591001C4591001 1123 11231453112314531123DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÊ.DW/ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÕüHr¨ÉüDWDÙHrÇˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÕüHr¨ÉüDWDÙHrÇˆ......Phase 3A@..DW/DWÊ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1123 11231453112314531123.DW/B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÊ.DW/ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDÕüHr¨ÉüDWDÙHrÇˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDÕüHr¨ÉüDWDÙHrÇˆ......Phase 3A@..DW/DWÊ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1123 11231454112314541123DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWnDW/ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÖtHr¨ÊtDWRDÐ Hsk Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW;DWR.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖtHr¨ÊtDWDØHrÇDW;D°@HsøÀDWRDÐ Hsk Phase 3A@..DW/.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSAC4591001C4591001 1123 11231454112314541123.DW/B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWnDW/ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÖtHr¨ÊtDWRDÐ Hsk Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW;DWR.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖtHr¨ÊtDWDØHrÇDW;D°@HsøÀDWRDÐ Hsk Phase 3A@..DW/.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA C4591001C4591001 1123 11231454112314541123DW;DW;BDREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWnDW/ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÖtHr¨ÊtDWRDÐ Hsk Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW;DWR.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖtHr¨ÊtDWDØHrÇDW;D°@HsøÀDWRDÐ Hsk Phase 3A@..DW/.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA0C4591001C4591001 1123 11231454112314541123.DWnBwOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWnDW/YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDÖtHr¨ÊtDWRDÐ Hsk Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW;DWR.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDÖtHr¨ÊtDWDØHrÇDW;D°@HsøÀDWRDÐ Hsk Phase 3A@..DW/.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA@C4591001C4591001 1123 11231455112314551123DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDñ,Hr¨å,DWDì¸HrÃ>¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDñ,Hr¨å,DWDì¸HrÃ>¸......Phase 3A@..DW)DW¼12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1123 11231455112314551123.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DW¼.DW) AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDñ,Hr¨å,DWDì¸HrÃ>¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDñ,Hr¨å,DWDì¸HrÃ>¸......Phase 3A@..DW)DW¼12-15 YearsAYYNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1123 11231456112314561123DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŠüHr©Ð|DW§DHs)ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŠüHr©Ð|DWDÅHrÃDW’D…ÔHss€ÔDW§DHs)ˆPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231456112314561123.DW)B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŠüHr©Ð|DW§DHs)ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŠüHr©Ð|DWDÅHrÃDW’D…ÔHss€ÔDW§DHs)ˆPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231456112314561123DW’DW’BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW) AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŠüHr©Ð|DW§DHs)ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŠüHr©Ð|DWDÅHrÃDW’D…ÔHss€ÔDW§DHs)ˆPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231456112314561123.DWÃBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÃDW)YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŠüHr©Ð|DW§DHs)ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŠüHr©Ð|DWDÅHrÃDW’D…ÔHss€ÔDW§DHs)ˆPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231457112314571123DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¿DW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDµàHr©û`DW£DŠHs‰îŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDµàHr©û`DWD‘HrÂãDWŽD—,HsnL,DW£DŠHs‰îŒPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1123 11231457112314571123.DW(B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¿DW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDµàHr©û`DW£DŠHs‰îŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDµàHr©û`DWD‘HrÂãDWŽD—,HsnL,DW£DŠHs‰îŒPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1123 11231457112314571123DWŽDWŽB–REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¿DW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDµàHr©û`DW£DŠHs‰îŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDµàHr©û`DWD‘HrÂãDWŽD—,HsnL,DW£DŠHs‰îŒPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1123 11231457112314571123.DW¿BÇOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DW¿DW(YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDµàHr©û`DW£DŠHs‰îŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DWŽDW£.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDµàHr©û`DWD‘HrÂãDWŽD—,HsnL,DW£DŠHs‰îŒPhase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1123 11231458112314581123DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÞ.DW( AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÎ|HrªüDWDá<HrÃ3<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÎ|HrªüDWDá<HrÃ3<......Phase 3A@..DW(DWÞ12-15 YearsAYYNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231458112314581123.DW(B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÞ.DW( AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÎ|HrªüDWDá<HrÃ3<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÎ|HrªüDWDá<HrÃ3<......Phase 3A@..DW(DWÞ12-15 YearsAYYNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231459112314591123DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÉ.DW( AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÝHrª"„DWDÓ,HrÃ%,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW6BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÝHrª"„DWDÓ,HrÃ%,......Phase 3A@..DW(DWÉ12-15 YearsAYYNY. DW5DWýDWýAðYEARSDSAC4591001C4591001 1123 11231459112314591123.DW(B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(DWÉ.DW( AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÝHrª"„DWDÓ,HrÃ%,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW6BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÝHrª"„DWDÓ,HrÃ%,......Phase 3A@..DW(DWÉ12-15 YearsAYYNY. DW5DWýDWýAðYEARSDSA C4591001C4591001 1123 11231460112314601123DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWjDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD²\Hr«I\DWMDÜŒHsàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW8DWM.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD²\Hr«I\DWDÉHrÈaDW8DïLHrýCLDWMDÜŒHsàPhase 3A@..DW,.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSAC4591001C4591001 1123 11231460112314601123.DW,B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWjDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD²\Hr«I\DWMDÜŒHsàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW8DWM.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD²\Hr«I\DWDÉHrÈaDW8DïLHrýCLDWMDÜŒHsàPhase 3A@..DW,.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA C4591001C4591001 1123 11231460112314601123DW8DW8B?REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWjDW, AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD²\Hr«I\DWMDÜŒHsàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW8DWM.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD²\Hr«I\DWDÉHrÈaDW8DïLHrýCLDWMDÜŒHsàPhase 3A@..DW,.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA0C4591001C4591001 1123 11231460112314601123.DWjBqOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWjDW,YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD²\Hr«I\DWMDÜŒHsàPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW8DWM.DW6Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD²\Hr«I\DWDÉHrÈaDW8DïLHrýCLDWMDÜŒHsàPhase 3A@..DW,.12-15 YearsA YNN. DW5DWýDWýAðYEARSDSA@C4591001C4591001 1123 11231461112314611123DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¼.DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD¶”Hr«M”DW D…ÔHrÄ)TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DW9BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD¶”Hr«M”DW D…ÔHrÄ)T......Phase 3A@..DW*DW¼12-15 YearsA YNY. DW8DWýDWýAðYEARSDSAC4591001C4591001 1123 11231461112314611123.DW*B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW¼.DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD¶”Hr«M”DW D…ÔHrÄ)TBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW ....DW9BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD¶”Hr«M”DW D…ÔHrÄ)T......Phase 3A@..DW*DW¼12-15 YearsA YNY. DW8DWýDWýAðYEARSDSA C4591001C4591001 1123 11231462112314621123DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DW¿.DW/ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD×(Hr«n(DWDÙHrÈqBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD×(Hr«n(DWDÙHrÈq......Phase 3A@..DW/DW¿12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1123 11231462112314621123.DW/B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DW¿.DW/ AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúD×(Hr«n(DWDÙHrÈqBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúD×(Hr«n(DWDÙHrÈq......Phase 3A@..DW/DW¿12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1123 11231463112314631123DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÍDW+ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD´ðHr¬pDW°D£ Hs›+ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWšDW°.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD´ðHr¬pDWD… HrÆË DWšDÌ$Hs~S$DW°D£ Hs›+ Phase 3A@..DW+.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSAC4591001C4591001 1123 11231463112314631123.DW+B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÍDW+ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD´ðHr¬pDW°D£ Hs›+ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWšDW°.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD´ðHr¬pDWD… HrÆË DWšDÌ$Hs~S$DW°D£ Hs›+ Phase 3A@..DW+.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA C4591001C4591001 1123 11231463112314631123DWšDWšB REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÍDW+ AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD´ðHr¬pDW°D£ Hs›+ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWšDW°.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD´ðHr¬pDWD… HrÆË DWšDÌ$Hs~S$DW°D£ Hs›+ Phase 3A@..DW+.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA0C4591001C4591001 1123 11231463112314631123.DWÍBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÍDW+YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD´ðHr¬pDW°D£ Hs›+ Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWšDW°.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD´ðHr¬pDWD… HrÆË DWšDÌ$Hs~S$DW°D£ Hs›+ Phase 3A@..DW+.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA@C4591001C4591001 1123 11231465112314651123DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÍÈHr¬¶HDW¨DÆHsÂPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW•DW¨.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÍÈHr¬¶HDWDÐ HrÈh DW•DÇ8Hsw¶¸DW¨DÆHsÂPhase 3A@..DW1.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSAC4591001C4591001 1123 11231465112314651123.DW1B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÍÈHr¬¶HDW¨DÆHsÂPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW•DW¨.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÍÈHr¬¶HDWDÐ HrÈh DW•DÇ8Hsw¶¸DW¨DÆHsÂPhase 3A@..DW1.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA C4591001C4591001 1123 11231465112314651123DW•DW•B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÍÈHr¬¶HDW¨DÆHsÂPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW•DW¨.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÍÈHr¬¶HDWDÐ HrÈh DW•DÇ8Hsw¶¸DW¨DÆHsÂPhase 3A@..DW1.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA0C4591001C4591001 1123 11231465112314651123.DWÄBÊOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÍÈHr¬¶HDW¨DÆHsÂPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW•DW¨.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÍÈHr¬¶HDWDÐ HrÈh DW•DÇ8Hsw¶¸DW¨DÆHsÂPhase 3A@..DW1.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA@C4591001C4591001 1123 11231466112314661123DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDØHr¬ÁDWDÍÈHrÅÂÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDØHr¬ÁDWDÍÈHrÅÂÈ......Phase 3A@..DW*DW½12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1123 11231466112314661123.DW*B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDØHr¬ÁDWDÍÈHrÅÂÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDØHr¬ÁDWDÍÈHrÅÂÈ......Phase 3A@..DW*DW½12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1123 11231467112314671123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DW½DW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD‚ÈHr°_ÈDW¡D€èHs‡BhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD‚ÈHr°_ÈDWDŠ„HrÌDWŽDštHsnOtDW¡D€èHs‡BhPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231467112314671123.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DW½DW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD‚ÈHr°_ÈDW¡D€èHs‡BhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD‚ÈHr°_ÈDWDŠ„HrÌDWŽDštHsnOtDW¡D€èHs‡BhPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231467112314671123DWŽDWŽB‘REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DW½DW6 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD‚ÈHr°_ÈDW¡D€èHs‡BhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD‚ÈHr°_ÈDWDŠ„HrÌDWŽDštHsnOtDW¡D€èHs‡BhPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231467112314671123.DW½BÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DW½DW6YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD‚ÈHr°_ÈDW¡D€èHs‡BhPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD‚ÈHr°_ÈDWDŠ„HrÌDWŽDštHsnOtDW¡D€èHs‡BhPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231468112314681123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÔDW0 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDƒ|Hr°`|DW¶D‹°Hs¢ü°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW£DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDƒ|Hr°`|DWDxxHrÌøDW£DŽHs‰òˆDW¶D‹°Hs¢ü°Phase 3A@..DW0.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSAC4591001C4591001 1123 11231468112314681123.DW0B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÔDW0 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDƒ|Hr°`|DW¶D‹°Hs¢ü°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW£DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDƒ|Hr°`|DWDxxHrÌøDW£DŽHs‰òˆDW¶D‹°Hs¢ü°Phase 3A@..DW0.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA C4591001C4591001 1123 11231468112314681123DW£DW£B¦REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÔDW0 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDƒ|Hr°`|DW¶D‹°Hs¢ü°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW£DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDƒ|Hr°`|DWDxxHrÌøDW£DŽHs‰òˆDW¶D‹°Hs¢ü°Phase 3A@..DW0.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA0C4591001C4591001 1123 11231468112314681123.DWÔB×OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÔDW0YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDƒ|Hr°`|DW¶D‹°Hs¢ü°Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW£DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDƒ|Hr°`|DWDxxHrÌøDW£DŽHs‰òˆDW¶D‹°Hs¢ü°Phase 3A@..DW0.12-15 YearsA YNN. DW’DWýDWýAðYEARSDSA@C4591001C4591001 1123 11231469112314691123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DWÍ.DW2 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¡|Hr°~|DWD’|HrÍp|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¡|Hr°~|DWD’|HrÍp|......Phase 3A@..DW2DWÍ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1123 11231469112314691123.DW2B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DWÍ.DW2 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD¡|Hr°~|DWD’|HrÍp|BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD¡|Hr°~|DWD’|HrÍp|......Phase 3A@..DW2DWÍ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1123 11231470112314701123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÌDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¬Hr°‰DW®D™„Hs˜~„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWšDW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¬Hr°‰DWDÕHrÏŒDWšDÆHHs~MHDW®D™„Hs˜~„Phase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231470112314701123.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÌDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¬Hr°‰DW®D™„Hs˜~„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWšDW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¬Hr°‰DWDÕHrÏŒDWšDÆHHs~MHDW®D™„Hs˜~„Phase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231470112314701123DWšDWšBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÌDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¬Hr°‰DW®D™„Hs˜~„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWšDW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¬Hr°‰DWDÕHrÏŒDWšDÆHHs~MHDW®D™„Hs˜~„Phase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231470112314701123.DWÌBÏOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÌDW1YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD¬Hr°‰DW®D™„Hs˜~„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWšDW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþD¬Hr°‰DWDÕHrÏŒDWšDÆHHs~MHDW®D™„Hs˜~„Phase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231472112314721123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÃ.DW7 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD´<Hr°‘<DWD… HrÍc BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD´<Hr°‘<DWD… HrÍc ......Phase 3A@..DW7DWÃ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1123 11231472112314721123.DW7B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7DWÃ.DW7 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþD´<Hr°‘<DWD… HrÍc BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþD´<Hr°‘<DWD… HrÍc ......Phase 3A@..DW7DWÃ12-15 YearsA YNY. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1123 11231473112314731123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÃDW0 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDµ,Hr°’,DW§Dª(HsT¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDµ,Hr°’,DWDÑLHrÍ¯LDW’Dî\Hssé\DW§Dª(HsT¨Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1123 11231473112314731123.DW0B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÃDW0 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDµ,Hr°’,DW§Dª(HsT¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDµ,Hr°’,DWDÑLHrÍ¯LDW’Dî\Hssé\DW§Dª(HsT¨Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1123 11231473112314731123DW’DW’B•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÃDW0 AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDµ,Hr°’,DW§Dª(HsT¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDµ,Hr°’,DWDÑLHrÍ¯LDW’Dî\Hssé\DW§Dª(HsT¨Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1123 11231473112314731123.DWÃBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÃDW0YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDµ,Hr°’,DW§Dª(HsT¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DW’DW§.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDµ,Hr°’,DWDÑLHrÍ¯LDW’Dî\Hssé\DW§Dª(HsT¨Phase 3A@..DW0.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1123 11231474112314741123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÓ¤Hr°°¤DWD}(HrÌ ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÓ¤Hr°°¤DWD}(HrÌ ¨......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231474112314741123.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÓ¤Hr°°¤DWD}(HrÌ ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÓ¤Hr°°¤DWD}(HrÌ ¨......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231475112314751123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÓ,Hr°°,DWD|°HrÌ 0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÓ,Hr°°,DWD|°HrÌ 0......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DW’DWýDWýAàYEARSDSAC4591001C4591001 1123 11231475112314751123.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDÓ,Hr°°,DWD|°HrÌ 0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDÓ,Hr°°,DWD|°HrÌ 0......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DW’DWýDWýAàYEARSDSA C4591001C4591001 1123 11231476112314761123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DW½DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÛ$Hr°¸$DW¡D«Hs‡l˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÛ$Hr°¸$DWDÁ˜HrÌNDWŽD¬DHsnaDDW¡D«Hs‡l˜Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231476112314761123.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DW½DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÛ$Hr°¸$DW¡D«Hs‡l˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÛ$Hr°¸$DWDÁ˜HrÌNDWŽD¬DHsnaDDW¡D«Hs‡l˜Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231476112314761123DWŽDWŽB‘REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DW½DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÛ$Hr°¸$DW¡D«Hs‡l˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÛ$Hr°¸$DWDÁ˜HrÌNDWŽD¬DHsnaDDW¡D«Hs‡l˜Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231476112314761123.DW½BÀOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DW½DW/YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDÛ$Hr°¸$DW¡D«Hs‡l˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVþDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVþDÛ$Hr°¸$DWDÁ˜HrÌNDWŽD¬DHsnaDDW¡D«Hs‡l˜Phase 3A@..DW/.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231477112314771123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÐ.DW/ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDè¼Hr°Å¼DWD›(HrÌ'¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDè¼Hr°Å¼DWD›(HrÌ'¨......Phase 3A@..DW(DWÐ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1123 11231477112314771123.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÐ.DW/ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDè¼Hr°Å¼DWD›(HrÌ'¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDè¼Hr°Å¼DWD›(HrÌ'¨......Phase 3A@..DW(DWÐ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1123 11231478112314781123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDé4Hr°Æ4DWDšìHrÌ'lPlacebo Placebo 12-15 YearsA . . .DVþDW....DW‘Placebo Placebo Placebo A .Placebo A .DVþDé4Hr°Æ4DWDšìHrÌ'l......Phase 3A@DW¨.DW/.12-15 YearsA YNN. DWDW¨DW¨AÐYEARSDSAC4591001C4591001 1123 11231478112314781123.DW/B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDé4Hr°Æ4DWDšìHrÌ'lPlacebo Placebo 12-15 YearsA . . .DVþDW....DW‘Placebo Placebo Placebo A .Placebo A .DVþDé4Hr°Æ4DWDšìHrÌ'l......Phase 3A@DW¨.DW/.12-15 YearsA YNN. DWDW¨DW¨AÐYEARSDSA C4591001C4591001 1123 11231478112314781123.DW¨B«FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BPatient did not want to participate in the crossover and requested to be dropped from the study. DW/..DW/YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDé4Hr°Æ4DWDšìHrÌ'lPlacebo Placebo 12-15 YearsA . . .DVþDW....DW‘Placebo Placebo Placebo A .Placebo A .DVþDé4Hr°Æ4DWDšìHrÌ'l......Phase 3A@DW¨.DW/.12-15 YearsA YNN. DWDW¨DW¨AÐYEARSDSApC4591001C4591001 1123 11231479112314791123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDàˆHr°½ˆDWDÏlHrÌ[ìPlacebo Placebo 12-15 YearsA . . .DVþDW....DWPlacebo Placebo Placebo A .Placebo A .DVþDàˆHr°½ˆDWDÏlHrÌ[ì......Phase 3A@DWŽ.DW6.12-15 YearsA YNN. DWŒDWŽDWŽAàYEARSDSAC4591001C4591001 1123 11231479112314791123.DW6B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDàˆHr°½ˆDWDÏlHrÌ[ìPlacebo Placebo 12-15 YearsA . . .DVþDW....DWPlacebo Placebo Placebo A .Placebo A .DVþDàˆHr°½ˆDWDÏlHrÌ[ì......Phase 3A@DWŽ.DW6.12-15 YearsA YNN. DWŒDWŽDWŽAàYEARSDSA C4591001C4591001 1123 11231479112314791123.DWŽB‘FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BPatient requested to be dropped because they did not want to come into clinic for any more visits DW6..DW6YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþDàˆHr°½ˆDWDÏlHrÌ[ìPlacebo Placebo 12-15 YearsA . . .DVþDW....DWPlacebo Placebo Placebo A .Placebo A .DVþDàˆHr°½ˆDWDÏlHrÌ[ì......Phase 3A@DWŽ.DW6.12-15 YearsA YNN. DWŒDWŽDWŽAàYEARSDSA`C4591001C4591001 1123 11231481112314811123DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWß.DW1 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDïˆHr°ÌˆDWD¯ÈHrÍÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDïˆHr°ÌˆDWD¯ÈHrÍÈ......Phase 3A@..DW1DWß12-15 YearsA YNY. DW’DWýDWýAðYEARSDSAC4591001C4591001 1123 11231481112314811123.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWß.DW1 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVþDïˆHr°ÌˆDWD¯ÈHrÍÈBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVþDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVþDïˆHr°ÌˆDWD¯ÈHrÍÈ......Phase 3A@..DW1DWß12-15 YearsA YNY. DW’DWýDWýAðYEARSDSA C4591001C4591001 1123 11231482112314821123DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÆ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDƒ@Hr±±ÀDWDÖ8HrÌb¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDƒ@Hr±±ÀDWDÖ8HrÌb¸......Phase 3A@..DW3DWÆ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231482112314821123.DW3B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÆ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDƒ@Hr±±ÀDWDÖ8HrÌb¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDƒ@Hr±±ÀDWDÖ8HrÌb¸......Phase 3A@..DW3DWÆ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231483112314831123DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0..DW0 AÀYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿD‹8Hr±¹¸DWDˆ,HrÌ¬Placebo Placebo 12-15 YearsA . . .DVÿDW....DW“Placebo Placebo Placebo A .Placebo A .DVÿD‹8Hr±¹¸DWDˆ,HrÌ¬......Phase 3A@DW©.DW0.12-15 YearsA YNN. DW’DW©DW©AÀYEARSDSAC4591001C4591001 1123 11231483112314831123.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0..DW0 AÀYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿD‹8Hr±¹¸DWDˆ,HrÌ¬Placebo Placebo 12-15 YearsA . . .DVÿDW....DW“Placebo Placebo Placebo A .Placebo A .DVÿD‹8Hr±¹¸DWDˆ,HrÌ¬......Phase 3A@DW©.DW0.12-15 YearsA YNN. DW’DW©DW©AÀYEARSDSA C4591001C4591001 1123 11231483112314831123.DW©B«FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APCan't reach patient to schedule V101 DW0..DW0YAÀYEARSFA MULTIPLE A`MULTIRACIAL A`YYPlacebo PLACEBO Placebo PLACEBO DVÿD‹8Hr±¹¸DWDˆ,HrÌ¬Placebo Placebo 12-15 YearsA . . .DVÿDW....DW“Placebo Placebo Placebo A .Placebo A .DVÿD‹8Hr±¹¸DWDˆ,HrÌ¬......Phase 3A@DW©.DW0.12-15 YearsA YNN. DW’DW©DW©AÀYEARSDSA@C4591001C4591001 1123 11231484112314841123DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÍ.DW3 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDØHr±¿XDWD†ÄHrÍdÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDØHr±¿XDWD†ÄHrÍdÄ......Phase 3A@..DW3DWÍ12-15 YearsA YNY. DW’DWýDWýAàYEARSDSAC4591001C4591001 1123 11231484112314841123.DW3B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÍ.DW3 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDØHr±¿XDWD†ÄHrÍdÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDØHr±¿XDWD†ÄHrÍdÄ......Phase 3A@..DW3DWÍ12-15 YearsA YNY. DW’DWýDWýAàYEARSDSA C4591001C4591001 1123 11231485112314851123DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÔDW0 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDŸ$Hr±Í¤DW¶D×dHs£HdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW¡DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDŸ$Hr±Í¤DWD„0HrÍb0DW¡DŠüHs‡L|DW¶D×dHs£HdPhase 3A@..DW0.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1123 11231485112314851123.DW0B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÔDW0 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDŸ$Hr±Í¤DW¶D×dHs£HdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW¡DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDŸ$Hr±Í¤DWD„0HrÍb0DW¡DŠüHs‡L|DW¶D×dHs£HdPhase 3A@..DW0.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1123 11231485112314851123DW¡DW¡B£REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÔDW0 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDŸ$Hr±Í¤DW¶D×dHs£HdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW¡DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDŸ$Hr±Í¤DWD„0HrÍb0DW¡DŠüHs‡L|DW¶D×dHs£HdPhase 3A@..DW0.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231485112314851123.DWÔBÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW0.DWÔDW0YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDŸ$Hr±Í¤DW¶D×dHs£HdPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW¡DW¶.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDŸ$Hr±Í¤DWD„0HrÍb0DW¡DŠüHs‡L|DW¶D×dHs£HdPhase 3A@..DW0.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231486112314861123DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD¤ÄHr±ÓDDWDÆHrÌRŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD¤ÄHr±ÓDDWDÆHrÌRŒ......Phase 3A@DWÒ.DW/.12-15 YearsA YNY. DWŒDWÒDWÒAàYEARSDSAC4591001C4591001 1123 11231486112314861123.DW/B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/..DW/ AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD¤ÄHr±ÓDDWDÆHrÌRŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD¤ÄHr±ÓDDWDÆHrÌRŒ......Phase 3A@DWÒ.DW/.12-15 YearsA YNY. DWŒDWÒDWÒAàYEARSDSA C4591001C4591001 1123 11231486112314861123.DWÒBÔFOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APNo Show for V4, can't reach subject DW/..DW/YAàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿD¤ÄHr±ÓDDWDÆHrÌRŒBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿD¤ÄHr±ÓDDWDÆHrÌRŒ......Phase 3A@DWÒ.DW/.12-15 YearsA YNY. DWŒDWÒDWÒAàYEARSDSAPC4591001C4591001 1123 11231487112314871123DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÌDW1 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDŸØHr±ÎXDW®DÕHHs˜ºHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWšDW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDŸØHr±ÎXDWDÑˆHrÌ^DWšDäHs~kDW®DÕHHs˜ºHPhase 3A@..DW1.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSAC4591001C4591001 1123 11231487112314871123.DW1B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÌDW1 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDŸØHr±ÎXDW®DÕHHs˜ºHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWšDW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDŸØHr±ÎXDWDÑˆHrÌ^DWšDäHs~kDW®DÕHHs˜ºHPhase 3A@..DW1.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA C4591001C4591001 1123 11231487112314871123DWšDWšBœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÌDW1 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDŸØHr±ÎXDW®DÕHHs˜ºHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWšDW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDŸØHr±ÎXDWDÑˆHrÌ^DWšDäHs~kDW®DÕHHs˜ºHPhase 3A@..DW1.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA0C4591001C4591001 1123 11231487112314871123.DWÌBÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÌDW1YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDŸØHr±ÎXDW®DÕHHs˜ºHPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DWšDW®.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDŸØHr±ÎXDWDÑˆHrÌ^DWšDäHs~kDW®DÕHHs˜ºHPhase 3A@..DW1.12-15 YearsA YNN. DW’DWýDWýAàYEARSDSA@C4591001C4591001 1123 11231488112314881123DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÉ.DW8 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÐ Hr±þ DWD¢äHrÎÒdBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÐ Hr±þ DWD¢äHrÎÒd......Phase 3A@..DW8DWÉ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231488112314881123.DW8B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÉ.DW8 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDÐ Hr±þ DWD¢äHrÎÒdBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDÐ Hr±þ DWD¢äHrÎÒd......Phase 3A@..DW8DWÉ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231489112314891123DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDØHr²˜DWD¬HrÌ8ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDØHr²˜DWD¬HrÌ8ˆ......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSAC4591001C4591001 1123 11231489112314891123.DW3B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVÿDØHr²˜DWD¬HrÌ8ˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVÿDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVÿDØHr²˜DWD¬HrÌ8ˆ......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DW‘DWýDWýAÐYEARSDSA C4591001C4591001 1123 11231491112314911123DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3..DW3 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDáxHr²øDWD¥xHrÌ1øPlacebo Placebo 12-15 YearsA . . .DVÿDW....DW‘Placebo Placebo Placebo A .Placebo A .DVÿDáxHr²øDWD¥xHrÌ1ø......Phase 3A@DW¨.DW3.12-15 YearsA YNN. DWDW¨DW¨AàYEARSDSAC4591001C4591001 1123 11231491112314911123.DW3B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3..DW3 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDáxHr²øDWD¥xHrÌ1øPlacebo Placebo 12-15 YearsA . . .DVÿDW....DW‘Placebo Placebo Placebo A .Placebo A .DVÿDáxHr²øDWD¥xHrÌ1ø......Phase 3A@DW¨.DW3.12-15 YearsA YNN. DWDW¨DW¨AàYEARSDSA C4591001C4591001 1123 11231491112314911123.DW¨BªFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject no longer wanted to participate in the crossover DW3..DW3YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDáxHr²øDWD¥xHrÌ1øPlacebo Placebo 12-15 YearsA . . .DVÿDW....DW‘Placebo Placebo Placebo A .Placebo A .DVÿDáxHr²øDWD¥xHrÌ1ø......Phase 3A@DW¨.DW3.12-15 YearsA YNN. DWDW¨DW¨AàYEARSDSApC4591001C4591001 1123 11231492112314921123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÄDW2 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr³¬DW¦DÀlHsŽlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr³¬DWD|ìHrÎ¬lDW’DèHssãDW¦DÀlHsŽlPhase 3A@..DW2.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1123 11231492112314921123.DW2B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÄDW2 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr³¬DW¦DÀlHsŽlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr³¬DWD|ìHrÎ¬lDW’DèHssãDW¦DÀlHsŽlPhase 3A@..DW2.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1123 11231492112314921123DW’DW’B“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÄDW2 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr³¬DW¦DÀlHsŽlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr³¬DWD|ìHrÎ¬lDW’DèHssãDW¦DÀlHsŽlPhase 3A@..DW2.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1123 11231492112314921123.DWÄBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÄDW2YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr³¬DW¦DÀlHsŽlPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW¦.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr³¬DWD|ìHrÎ¬lDW’DèHssãDW¦DÀlHsŽlPhase 3A@..DW2.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1123 11231493112314931123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWË.DW3 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD˜”Hr³”DWDÊDHrÑœÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD˜”Hr³”DWDÊDHrÑœÄ......Phase 3A@..DW3DWË12-15 YearsA YNY. DW’DWýDWýAàYEARSDSAC4591001C4591001 1123 11231493112314931123.DW3B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWË.DW3 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD˜”Hr³”DWDÊDHrÑœÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD˜”Hr³”DWDÊDHrÑœÄ......Phase 3A@..DW3DWË12-15 YearsA YNY. DW’DWýDWýAàYEARSDSA C4591001C4591001 1123 11231494112314941123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DWÉ.DW2 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡@Hr³!@DWDÛ`HrÐ\`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡@Hr³!@DWDÛ`HrÐ\`......Phase 3A@..DW2DWÉ12-15 YearsA YNY. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1123 11231494112314941123.DW2B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DWÉ.DW2 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¡@Hr³!@DWDÛ`HrÐ\`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¡@Hr³!@DWDÛ`HrÐ\`......Phase 3A@..DW2DWÉ12-15 YearsA YNY. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1123 11231495112314951123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÌ.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD©°Hr³)°DWDÍŒHrÎýBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD©°Hr³)°DWDÍŒHrÎý......Phase 3A@..DW1DWÌ12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1123 11231495112314951123.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÌ.DW1 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD©°Hr³)°DWDÍŒHrÎýBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD©°Hr³)°DWDÍŒHrÎý......Phase 3A@..DW1DWÌ12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1123 11231496112314961123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWËDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©tHr³)tDW¯D—hHs™ÍèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©tHr³)tDWDÍPHrÎüÐDW™Dá<Hs}¼DW¯D—hHs™ÍèPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231496112314961123.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWËDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©tHr³)tDW¯D—hHs™ÍèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©tHr³)tDWDÍPHrÎüÐDW™Dá<Hs}¼DW¯D—hHs™ÍèPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231496112314961123DW™DW™BšREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWËDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©tHr³)tDW¯D—hHs™ÍèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©tHr³)tDWDÍPHrÎüÐDW™Dá<Hs}¼DW¯D—hHs™ÍèPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231496112314961123.DWËBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWËDW1YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©tHr³)tDW¯D—hHs™ÍèPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW¯.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©tHr³)tDWDÍPHrÎüÐDW™Dá<Hs}¼DW¯D—hHs™ÍèPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231497112314971123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÑDW9 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDµ,Hr³5,DW±DÇtHsœ ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW±.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDµ,Hr³5,DWD„0Hr×î0DWœDæ Hs DW±DÇtHsœ ôPhase 3A@..DW9.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1123 11231497112314971123.DW9B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÑDW9 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDµ,Hr³5,DW±DÇtHsœ ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW±.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDµ,Hr³5,DWD„0Hr×î0DWœDæ Hs DW±DÇtHsœ ôPhase 3A@..DW9.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1123 11231497112314971123DWœDWœBREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÑDW9 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDµ,Hr³5,DW±DÇtHsœ ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW±.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDµ,Hr³5,DWD„0Hr×î0DWœDæ Hs DW±DÇtHsœ ôPhase 3A@..DW9.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231497112314971123.DWÑBÒOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÑDW9YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDµ,Hr³5,DW±DÇtHsœ ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWœDW±.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDµ,Hr³5,DWD„0Hr×î0DWœDæ Hs DW±DÇtHsœ ôPhase 3A@..DW9.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231499112314991123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DW½DW6 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr¹§,DW¡DŠHHs‡KÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr¹§,DWDŒÜHrÕSÜDWŽDÌHsnBÌDW¡DŠHHs‡KÈPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1123 11231499112314991123.DW6B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DW½DW6 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr¹§,DW¡DŠHHs‡KÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr¹§,DWDŒÜHrÕSÜDWŽDÌHsnBÌDW¡DŠHHs‡KÈPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1123 11231499112314991123DWŽDWŽBŠREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DW½DW6 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr¹§,DW¡DŠHHs‡KÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr¹§,DWDŒÜHrÕSÜDWŽDÌHsnBÌDW¡DŠHHs‡KÈPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1123 11231499112314991123.DW½B¹OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DW½DW6YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD¬Hr¹§,DW¡DŠHHs‡KÈPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWŽDW¡.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD¬Hr¹§,DWDŒÜHrÕSÜDWŽDÌHsnBÌDW¡DŠHHs‡KÈPhase 3A@..DW6.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1123 11231500112315001123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD•ÄHr¹DDWDŒ HrÕS BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD•ÄHr¹DDWDŒ HrÕS ......Phase 3A@..DW6.12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1123 11231500112315001123.DW6B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD•ÄHr¹DDWDŒ HrÕS BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD•ÄHr¹DDWDŒ HrÕS ......Phase 3A@..DW6.12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1123 11231501112315011123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWY.DWÆDWY AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°Hr¹Ç„DWªDÀ¨Hs“_¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW9.DW•DWª.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°Hr¹Ç„DW9DÙHrþ~ˆDW•DÝ@HswÌÀDWªDÀ¨Hs“_¨Phase 3A@..DWY.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231501112315011123.DWYBUVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWY.DWÆDWY AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°Hr¹Ç„DWªDÀ¨Hs“_¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW9.DW•DWª.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°Hr¹Ç„DW9DÙHrþ~ˆDW•DÝ@HswÌÀDWªDÀ¨Hs“_¨Phase 3A@..DWY.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231501112315011123DW•DW•B‘REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWY.DWÆDWY AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°Hr¹Ç„DWªDÀ¨Hs“_¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW9.DW•DWª.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°Hr¹Ç„DW9DÙHrþ~ˆDW•DÝ@HswÌÀDWªDÀ¨Hs“_¨Phase 3A@..DWY.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA0C4591001C4591001 1123 11231501112315011123.DWÆBÂOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWY.DWÆDWYYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°Hr¹Ç„DWªDÀ¨Hs“_¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW9.DW•DWª.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°Hr¹Ç„DW9DÙHrþ~ˆDW•DÝ@HswÌÀDWªDÀ¨Hs“_¨Phase 3A@..DWY.12-15 YearsA YNN. DW‘DWýDWýAÀYEARSDSA@C4591001C4591001 1123 11231502112315021123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÊ.DW9 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD°|Hr¹ÇüDWDæ(HrÖþ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD°|Hr¹ÇüDWDæ(HrÖþ¨......Phase 3A@..DW9DWÊ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1123 11231502112315021123.DW9B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWÊ.DW9 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD°|Hr¹ÇüDWDæ(HrÖþ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD°|Hr¹ÇüDWDæ(HrÖþ¨......Phase 3A@..DW9DWÊ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1123 11231503112315031123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÅDW9 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHr¹ÄðDW¨DÆ„HsÂ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHr¹ÄðDWD„äHrÕKäDW•DÇ8Hsw¶¸DW¨DÆ„HsÂ„Phase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231503112315031123.DW9B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÅDW9 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHr¹ÄðDW¨DÆ„HsÂ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHr¹ÄðDWD„äHrÕKäDW•DÇ8Hsw¶¸DW¨DÆ„HsÂ„Phase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231503112315031123DW•DW•B‘REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÅDW9 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHr¹ÄðDW¨DÆ„HsÂ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHr¹ÄðDWD„äHrÕKäDW•DÇ8Hsw¶¸DW¨DÆ„HsÂ„Phase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231503112315031123.DWÅBÁOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÅDW9YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDpHr¹ÄðDW¨DÆ„HsÂ„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDpHr¹ÄðDWD„äHrÕKäDW•DÇ8Hsw¶¸DW¨DÆ„HsÂ„Phase 3A@..DW9.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231504112315041123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÉ.DW8 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙøHr¹ñxDWD†ÄHrÕMÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙøHr¹ñxDWD†ÄHrÕMÄ......Phase 3A@..DW8DWÉ12-15 YearsA YNY. DW’DWýDWýAðYEARSDSAC4591001C4591001 1123 11231504112315041123.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÉ.DW8 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÙøHr¹ñxDWD†ÄHrÕMÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÙøHr¹ñxDWD†ÄHrÕMÄ......Phase 3A@..DW8DWÉ12-15 YearsA YNY. DW’DWýDWýAðYEARSDSA C4591001C4591001 1123 11231505112315051123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÑDW8 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÚ4Hr¹ñ´DWµD“äHs¡³dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÚ4Hr¹ñ´DWD†ˆHrÕMˆDW D—àHs†àDWµD“äHs¡³dPhase 3A@..DW8.12-15 YearsA YNN. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231505112315051123.DW8B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÑDW8 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÚ4Hr¹ñ´DWµD“äHs¡³dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÚ4Hr¹ñ´DWD†ˆHrÕMˆDW D—àHs†àDWµD“äHs¡³dPhase 3A@..DW8.12-15 YearsA YNN. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231505112315051123DW DW BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÑDW8 AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÚ4Hr¹ñ´DWµD“äHs¡³dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÚ4Hr¹ñ´DWD†ˆHrÕMˆDW D—àHs†àDWµD“äHs¡³dPhase 3A@..DW8.12-15 YearsA YNN. DW’DWýDWýAÀYEARSDSA0C4591001C4591001 1123 11231505112315051123.DWÑBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÑDW8YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÚ4Hr¹ñ´DWµD“äHs¡³dPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW DWµ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÚ4Hr¹ñ´DWD†ˆHrÕMˆDW D—àHs†àDWµD“äHs¡³dPhase 3A@..DW8.12-15 YearsA YNN. DW’DWýDWýAÀYEARSDSA@C4591001C4591001 1123 11231506112315061123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDá<Hr¹ø¼DWDŸ`HrÕf`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDá<Hr¹ø¼DWDŸ`HrÕf`......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231506112315061123.DW6B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDá<Hr¹ø¼DWDŸ`HrÕf`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDá<Hr¹ø¼DWDŸ`HrÕf`......Phase 3A@..DW6DWÉ12-15 YearsA YNY. DW‘DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231507112315071123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDí0Hrº°DWD¦hHrÕmhBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDí0Hrº°DWD¦hHrÕmh......Phase 3A@..DW7.12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1123 11231507112315071123.DW7B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW7..DW7 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDí0Hrº°DWD¦hHrÕmhBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDí0Hrº°DWD¦hHrÕmh......Phase 3A@..DW7.12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1123 11231508112315081123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:DWË.DW: AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDílHrºìDWDƒ¸Hr×í¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDílHrºìDWDƒ¸Hr×í¸......Phase 3A@..DW:DWË12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231508112315081123.DW:B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:DWË.DW: AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDílHrºìDWDƒ¸Hr×í¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDílHrºìDWDƒ¸Hr×í¸......Phase 3A@..DW:DWË12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231509112315091123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÌDW@ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©°Hr»°DW°DÒHs›ZPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWšDW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©°Hr»°DWDÊ€HrÙ†DWšDäüHs~küDW°DÒHs›ZPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1123 11231509112315091123.DW@B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÌDW@ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©°Hr»°DW°DÒHs›ZPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWšDW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©°Hr»°DWDÊ€HrÙ†DWšDäüHs~küDW°DÒHs›ZPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1123 11231509112315091123DWšDWšB•REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÌDW@ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©°Hr»°DW°DÒHs›ZPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWšDW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©°Hr»°DWDÊ€HrÙ†DWšDäüHs~küDW°DÒHs›ZPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1123 11231509112315091123.DWÌBÇOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÌDW@YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD©°Hr»°DW°DÒHs›ZPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWšDW°.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD©°Hr»°DWDÊ€HrÙ†DWšDäüHs~küDW°DÒHs›ZPhase 3A@..DW@.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1123 11231510112315101123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÌDW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD²˜Hr»˜DW®D¦àHs˜‹àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD²˜Hr»˜DWDÕ„HrÖîDW™DØTHs} ÔDW®D¦àHs˜‹àPhase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1123 11231510112315101123.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÌDW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD²˜Hr»˜DW®D¦àHs˜‹àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD²˜Hr»˜DWDÕ„HrÖîDW™DØTHs} ÔDW®D¦àHs˜‹àPhase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1123 11231510112315101123DW™DW™B”REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÌDW8 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD²˜Hr»˜DW®D¦àHs˜‹àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD²˜Hr»˜DWDÕ„HrÖîDW™DØTHs} ÔDW®D¦àHs˜‹àPhase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231510112315101123.DWÌBÇOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÌDW8YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD²˜Hr»˜DW®D¦àHs˜‹àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD²˜Hr»˜DWDÕ„HrÖîDW™DØTHs} ÔDW®D¦àHs˜‹àPhase 3A@..DW8.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231511112315111123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=..DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD`Hr¼JàDWDÛØHrÖôXBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD`Hr¼JàDWDÛØHrÖôX......Phase 3A@DWŠ.DW=.12-15 YearsA YNN. DWŠ.DWŠAÐYEARSDSAC4591001C4591001 1123 11231511112315111123.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=..DW= AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD`Hr¼JàDWDÛØHrÖôXBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD`Hr¼JàDWDÛØHrÖôX......Phase 3A@DWŠ.DW=.12-15 YearsA YNN. DWŠ.DWŠAÐYEARSDSA C4591001C4591001 1123 11231511112315111123.DWŠB„FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APCould not reach patient via telephone DW=..DW=YAÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD`Hr¼JàDWDÛØHrÖôXBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD`Hr¼JàDWDÛØHrÖôX......Phase 3A@DWŠ.DW=.12-15 YearsA YNN. DWŠ.DWŠAÐYEARSDSAPC4591001C4591001 1123 11231512112315121123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW=..DW= AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœHr¼KDWDÜHrÖô”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœHr¼KDWDÜHrÖô”......Phase 3A@DWŠ.DW=.12-15 YearsA YNN. DWŠ.DWŠAÐYEARSDSAC4591001C4591001 1123 11231512112315121123.DW=B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW=..DW= AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœHr¼KDWDÜHrÖô”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœHr¼KDWDÜHrÖô”......Phase 3A@DWŠ.DW=.12-15 YearsA YNN. DWŠ.DWŠAÐYEARSDSA C4591001C4591001 1123 11231512112315121123.DWŠB„FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APCouldn't reach patient via telephone. DW=..DW=YAÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDœHr¼KDWDÜHrÖô”BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDœHr¼KDWDÜHrÖô”......Phase 3A@DWŠ.DW=.12-15 YearsA YNN. DWŠ.DWŠAÐYEARSDSAPC4591001C4591001 1123 11231513112315131123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÙDW> AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–Hr¼P€DW½DŽ¼Hs¬:<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWªDW½.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–Hr¼P€DWDÇ°HrØ1°DWªDš8Hs“98DW½DŽ¼Hs¬:<Phase 3A@..DW>.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1123 11231513112315131123.DW>B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÙDW> AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–Hr¼P€DW½DŽ¼Hs¬:<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWªDW½.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–Hr¼P€DWDÇ°HrØ1°DWªDš8Hs“98DW½DŽ¼Hs¬:<Phase 3A@..DW>.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1123 11231513112315131123DWªDWªB¤REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÙDW> AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–Hr¼P€DW½DŽ¼Hs¬:<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWªDW½.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–Hr¼P€DWDÇ°HrØ1°DWªDš8Hs“98DW½DŽ¼Hs¬:<Phase 3A@..DW>.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1123 11231513112315131123.DWÙBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWÙDW>YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD–Hr¼P€DW½DŽ¼Hs¬:<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DWªDW½.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD–Hr¼P€DWDÇ°HrØ1°DWªDš8Hs“98DW½DŽ¼Hs¬:<Phase 3A@..DW>.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1123 11231514112315141123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÌDW9 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÇ8Hr¼¸DW®D™HHs˜~HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÇ8Hr¼¸DWDÆHrÕDW™D Hs|Õ”DW®D™HHs˜~HPhase 3A@..DW9.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSAC4591001C4591001 1123 11231514112315141123.DW9B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÌDW9 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÇ8Hr¼¸DW®D™HHs˜~HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÇ8Hr¼¸DWDÆHrÕDW™D Hs|Õ”DW®D™HHs˜~HPhase 3A@..DW9.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA C4591001C4591001 1123 11231514112315141123DW™DW™B“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÌDW9 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÇ8Hr¼¸DW®D™HHs˜~HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÇ8Hr¼¸DWDÆHrÕDW™D Hs|Õ”DW®D™HHs˜~HPhase 3A@..DW9.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA0C4591001C4591001 1123 11231514112315141123.DWÌBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÌDW9YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÇ8Hr¼¸DW®D™HHs˜~HPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW™DW®.DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÇ8Hr¼¸DWDÆHrÕDW™D Hs|Õ”DW®D™HHs˜~HPhase 3A@..DW9.12-15 YearsA YNN. DW‘DWýDWýAðYEARSDSA@C4591001C4591001 1123 11231515112315151123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDß\Hr¼™ÜDWDÅ”HrÕŒ”Placebo Placebo 12-15 YearsA . . .DWDW....DW“Placebo Placebo Placebo A .Placebo A .DWDß\Hr¼™ÜDWDÅ”HrÕŒ”......Phase 3A@DWœ.DW6.12-15 YearsA YNN. DW’DWœDWœAàYEARSDSAC4591001C4591001 1123 11231515112315151123.DW6B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6..DW6 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDß\Hr¼™ÜDWDÅ”HrÕŒ”Placebo Placebo 12-15 YearsA . . .DWDW....DW“Placebo Placebo Placebo A .Placebo A .DWDß\Hr¼™ÜDWDÅ”HrÕŒ”......Phase 3A@DWœ.DW6.12-15 YearsA YNN. DW’DWœDWœAàYEARSDSA C4591001C4591001 1123 11231515112315151123.DWœB–FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject requested withdrawal from study due to fears of blood collection. DW6..DW6YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDß\Hr¼™ÜDWDÅ”HrÕŒ”Placebo Placebo 12-15 YearsA . . .DWDW....DW“Placebo Placebo Placebo A .Placebo A .DWDß\Hr¼™ÜDWDÅ”HrÕŒ”......Phase 3A@DWœ.DW6.12-15 YearsA YNN. DW’DWœDWœAàYEARSDSApC4591001C4591001 1123 11231516112315161123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWèDW9 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDå8Hr¼Ÿ¸DWÅDâ,Hs·¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW®DWÅ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDå8Hr¼Ÿ¸DWDÐÔHrØ:ÔDW®DáðHs˜ÆðDWÅDâ,Hs·¬Phase 3A@..DW9.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSAC4591001C4591001 1123 11231516112315161123.DW9B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWèDW9 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDå8Hr¼Ÿ¸DWÅDâ,Hs·¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW®DWÅ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDå8Hr¼Ÿ¸DWDÐÔHrØ:ÔDW®DáðHs˜ÆðDWÅDâ,Hs·¬Phase 3A@..DW9.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA C4591001C4591001 1123 11231516112315161123DW®DW®B¨REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWèDW9 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDå8Hr¼Ÿ¸DWÅDâ,Hs·¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW®DWÅ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDå8Hr¼Ÿ¸DWDÐÔHrØ:ÔDW®DáðHs˜ÆðDWÅDâ,Hs·¬Phase 3A@..DW9.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA0C4591001C4591001 1123 11231516112315161123.DWèBâOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWèDW9YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDå8Hr¼Ÿ¸DWÅDâ,Hs·¬Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW®DWÅ.DW“Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDå8Hr¼Ÿ¸DWDÐÔHrØ:ÔDW®DáðHs˜ÆðDWÅDâ,Hs·¬Phase 3A@..DW9.12-15 YearsA YNN. DW’DWýDWýAÐYEARSDSA@C4591001C4591001 1123 11231517112315171123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:DWË.DW: AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÛ$Hr¼•¤DWD´xHrÕ{xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÛ$Hr¼•¤DWD´xHrÕ{x......Phase 3A@..DW:DWË12-15 YearsA YNY. DW’DWýDWýAðYEARSDSAC4591001C4591001 1123 11231517112315171123.DW:B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:DWË.DW: AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÛ$Hr¼•¤DWD´xHrÕ{xBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÛ$Hr¼•¤DWD´xHrÕ{x......Phase 3A@..DW:DWË12-15 YearsA YNY. DW’DWýDWýAðYEARSDSA C4591001C4591001 1123 11231518112315181123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9DWË.DW9 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDäüHr¼Ÿ|DWDÑHrØ;BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDäüHr¼Ÿ|DWDÑHrØ;......Phase 3A@..DW9DWË12-15 YearsA YNY. DW’DWýDWýAðYEARSDSAC4591001C4591001 1123 11231518112315181123.DW9B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9DWË.DW9 AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDäüHr¼Ÿ|DWDÑHrØ;BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDäüHr¼Ÿ|DWDÑHrØ;......Phase 3A@..DW9DWË12-15 YearsA YNY. DW’DWýDWýAðYEARSDSA C4591001C4591001 1123 11231519112315191123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDî\Hr¼¨ÜDWDž4HrØ4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDî\Hr¼¨ÜDWDž4HrØ4......Phase 3A@..DW8DWË12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1123 11231519112315191123.DW8B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWË.DW8 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDî\Hr¼¨ÜDWDž4HrØ4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDî\Hr¼¨ÜDWDž4HrØ4......Phase 3A@..DW8DWË12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231520112315201123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÉDW6 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòXHr¼¬ØDWªD‰XHs“(XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDòXHr¼¬ØDWD³LHrÕzLDW•DàLHswÏÌDWªD‰XHs“(XPhase 3A@..DW6.12-15 YearsA YNN. DW”DWýDWýAÀYEARSDSA C4591001C4591001 1123 11231520112315201123.DW6B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÉDW6 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòXHr¼¬ØDWªD‰XHs“(XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDòXHr¼¬ØDWD³LHrÕzLDW•DàLHswÏÌDWªD‰XHs“(XPhase 3A@..DW6.12-15 YearsA YNN. DW”DWýDWýAÀYEARSDSA0C4591001C4591001 1123 11231520112315201123DW•DW•BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÉDW6 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòXHr¼¬ØDWªD‰XHs“(XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDòXHr¼¬ØDWD³LHrÕzLDW•DàLHswÏÌDWªD‰XHs“(XPhase 3A@..DW6.12-15 YearsA YNN. DW”DWýDWýAÀYEARSDSA@C4591001C4591001 1123 11231520112315201123.DWÉBÃOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÉDW6YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDòXHr¼¬ØDWªD‰XHs“(XPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW•DWª.DW•Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDòXHr¼¬ØDWD³LHrÕzLDW•DàLHswÏÌDWªD‰XHs“(XPhase 3A@..DW6.12-15 YearsA YNN. DW”DWýDWýAÀYEARSDSAPC4591001C4591001 1123 11231521112315211123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDòXHr¼¬ØDWD³ÄHrÕzÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDòXHr¼¬ØDWD³ÄHrÕzÄ......Phase 3A@...DWÉ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1123 11231521112315211123.DW6B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6DWÉ.DW6 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDòXHr¼¬ØDWD³ÄHrÕzÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDòXHr¼¬ØDWD³ÄHrÕzÄ......Phase 3A@...DWÉ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1123 11231522112315221123DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÄ¤HrÄh$DW§D¿¸Hsj8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÄ¤HrÄh$DW"DÜHrà/DW’D¨ÀHss£ÀDW§D¿¸Hsj8Phase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1123 11231522112315221123.DW@B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÄ¤HrÄh$DW§D¿¸Hsj8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÄ¤HrÄh$DW"DÜHrà/DW’D¨ÀHss£ÀDW§D¿¸Hsj8Phase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1123 11231522112315221123DW’DW’B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÄ¤HrÄh$DW§D¿¸Hsj8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÄ¤HrÄh$DW"DÜHrà/DW’D¨ÀHss£ÀDW§D¿¸Hsj8Phase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1123 11231522112315221123.DWÄB¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÄ¤HrÄh$DW§D¿¸Hsj8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÄ¤HrÄh$DW"DÜHrà/DW’D¨ÀHss£ÀDW§D¿¸Hsj8Phase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1123 11231523112315231123DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÄ¤HrÄh$DW§D¿ôHsjtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÄ¤HrÄh$DW"DÜPHrà/PDW’D©ìHss¤ìDW§D¿ôHsjtPhase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1123 11231523112315231123.DW@B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÄ¤HrÄh$DW§D¿ôHsjtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÄ¤HrÄh$DW"DÜPHrà/PDW’D©ìHss¤ìDW§D¿ôHsjtPhase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1123 11231523112315231123DW’DW’B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÄ¤HrÄh$DW§D¿ôHsjtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÄ¤HrÄh$DW"DÜPHrà/PDW’D©ìHss¤ìDW§D¿ôHsjtPhase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1123 11231523112315231123.DWÄB¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW@.DWÄDW@YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DÄ¤HrÄh$DW§D¿ôHsjtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DÄ¤HrÄh$DW"DÜPHrà/PDW’D©ìHss¤ìDW§D¿ôHsjtPhase 3A@..DW@.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1123 11231524112315241123DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÝ@HrÄ€ÀDW$DãÐHrâÙÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÝ@HrÄ€ÀDW$DãÐHrâÙÐ......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1123 11231524112315241123.DW@B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW@DWÓ.DW@ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DÝ@HrÄ€ÀDW$DãÐHrâÙÐBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW$....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DÝ@HrÄ€ÀDW$DãÐHrâÙÐ......Phase 3A@..DW@DWÓ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1123 11231525112315251123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWGDWÙ.DWG AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèøHrÇ/xDW%DÚ4Hrä!´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèøHrÇ/xDW%DÚ4Hrä!´......Phase 3A@..DWGDWÙ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSAC4591001C4591001 1123 11231525112315251123.DWGB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWGDWÙ.DWG AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDèøHrÇ/xDW%DÚ4Hrä!´BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW%....DW’BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDèøHrÇ/xDW%DÚ4Hrä!´......Phase 3A@..DWGDWÙ12-15 YearsA YNY. DW‘DWýDWýAàYEARSDSA C4591001C4591001 1123 11231526112315261123DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD†LHrÈLDW™Dß Hs} Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW™..DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD†LHrÈLDW%DØHrãÉXDW™Dß Hs} DW™Dß Hs} Phase 3A@DW½.DWF.12-15 YearsA YNN. DW‘DW½DW½AàYEARSDSAC4591001C4591001 1123 11231526112315261123.DWFB7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD†LHrÈLDW™Dß Hs} Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW™..DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD†LHrÈLDW%DØHrãÉXDW™Dß Hs} DW™Dß Hs} Phase 3A@DW½.DWF.12-15 YearsA YNN. DW‘DW½DW½AàYEARSDSA C4591001C4591001 1123 11231526112315261123DW™DW™BŠREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWF..DWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD†LHrÈLDW™Dß Hs} Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW™..DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD†LHrÈLDW%DØHrãÉXDW™Dß Hs} DW™Dß Hs} Phase 3A@DW½.DWF.12-15 YearsA YNN. DW‘DW½DW½AàYEARSDSA0C4591001C4591001 1123 11231526112315261123.DW½B®FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APPatient consistently no-showed for V102. DWF..DWFYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD†LHrÈLDW™Dß Hs} Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW%.DW™..DW’Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD†LHrÈLDW%DØHrãÉXDW™Dß Hs} DW™Dß Hs} Phase 3A@DW½.DWF.12-15 YearsA YNN. DW‘DW½DW½AàYEARSDSApC4591001C4591001 1124 11241236112412361124DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(..DW( AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DV÷Dž¬Hr§A,DWD˜XHrÂêXPlacebo Placebo 12-15 YearsA . . .DV÷DW....DWPlacebo Placebo Placebo A .Placebo A .DV÷Dž¬Hr§A,DWD˜XHrÂêX......Phase 3A@DW .DW(.12-15 YearsA YNN. DWŒDW DW AÐYEARSDSAC4591001C4591001 1124 11241236112412361124.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(..DW( AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DV÷Dž¬Hr§A,DWD˜XHrÂêXPlacebo Placebo 12-15 YearsA . . .DV÷DW....DWPlacebo Placebo Placebo A .Placebo A .DV÷Dž¬Hr§A,DWD˜XHrÂêX......Phase 3A@DW .DW(.12-15 YearsA YNN. DWŒDW DW AÐYEARSDSA C4591001C4591001 1124 11241236112412361124.DW BªFOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BOUT OF COUNTRY DW(..DW(YAÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DV÷Dž¬Hr§A,DWD˜XHrÂêXPlacebo Placebo 12-15 YearsA . . .DV÷DW....DWPlacebo Placebo Placebo A .Placebo A .DV÷Dž¬Hr§A,DWD˜XHrÂêX......Phase 3A@DW .DW(.12-15 YearsA YNN. DWŒDW DW AÐYEARSDSA`C4591001C4591001 1124 11241238112412381124DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÖ°Hr§y0DWDÞ0HrÅÓ0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÖ°Hr§y0DWDÞ0HrÅÓ0......Phase 3A@..DW*DW½12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241238112412381124.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DÖ°Hr§y0DWDÞ0HrÅÓ0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DÖ°Hr§y0DWDÞ0HrÅÓ0......Phase 3A@..DW*DW½12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1124 11241239112412391124DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D×ÜHr§z\DWDåìHrÅÚìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D×ÜHr§z\DWDåìHrÅÚì......Phase 3A@..DW*DW½12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1124 11241239112412391124.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D×ÜHr§z\DWDåìHrÅÚìBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D×ÜHr§z\DWDåìHrÅÚì......Phase 3A@..DW*DW½12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1124 11241240112412401124DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWËDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DàˆHr§ƒDW¨Dâ¤HsÞ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DàˆHr§ƒDWDÑˆHrÃ#ˆDW‘DáxHsrŠøDW¨Dâ¤HsÞ¤Phase 3A@..DW*.12-15 YearsA YNN. DW…DWýDWýAðYEARSDSAC4591001C4591001 1124 11241240112412401124.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWËDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DàˆHr§ƒDW¨Dâ¤HsÞ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DàˆHr§ƒDWDÑˆHrÃ#ˆDW‘DáxHsrŠøDW¨Dâ¤HsÞ¤Phase 3A@..DW*.12-15 YearsA YNN. DW…DWýDWýAðYEARSDSA C4591001C4591001 1124 11241240112412401124DW‘DW‘B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWËDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DàˆHr§ƒDW¨Dâ¤HsÞ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DàˆHr§ƒDWDÑˆHrÃ#ˆDW‘DáxHsrŠøDW¨Dâ¤HsÞ¤Phase 3A@..DW*.12-15 YearsA YNN. DW…DWýDWýAðYEARSDSA0C4591001C4591001 1124 11241240112412401124.DWËBÕOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWËDW*YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DàˆHr§ƒDW¨Dâ¤HsÞ¤Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DàˆHr§ƒDWDÑˆHrÃ#ˆDW‘DáxHsrŠøDW¨Dâ¤HsÞ¤Phase 3A@..DW*.12-15 YearsA YNN. DW…DWýDWýAðYEARSDSA@C4591001C4591001 1124 11241241112412411124DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWËDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DàLHr§‚ÌDW¨DãHsßPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DàLHr§‚ÌDWDÑHrÃ#DW‘DáHsrŠ€DW¨DãHsßPhase 3A@..DW*.12-15 YearsA YNN. DW…DWýDWýAÐYEARSDSAC4591001C4591001 1124 11241241112412411124.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWËDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DàLHr§‚ÌDW¨DãHsßPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DàLHr§‚ÌDWDÑHrÃ#DW‘DáHsrŠ€DW¨DãHsßPhase 3A@..DW*.12-15 YearsA YNN. DW…DWýDWýAÐYEARSDSA C4591001C4591001 1124 11241241112412411124DW‘DW‘B›REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWËDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DàLHr§‚ÌDW¨DãHsßPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DàLHr§‚ÌDWDÑHrÃ#DW‘DáHsrŠ€DW¨DãHsßPhase 3A@..DW*.12-15 YearsA YNN. DW…DWýDWýAÐYEARSDSA0C4591001C4591001 1124 11241241112412411124.DWËBÕOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWËDW*YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DàLHr§‚ÌDW¨DãHsßPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DàLHr§‚ÌDWDÑHrÃ#DW‘DáHsrŠ€DW¨DãHsßPhase 3A@..DW*.12-15 YearsA YNN. DW…DWýDWýAÐYEARSDSA@C4591001C4591001 1124 11241242112412421124DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DïÄHr§’DDW DÐ\HrÄsÜPlacebo Placebo 12-15 YearsA . . .DV÷DW ....DWŽPlacebo Placebo Placebo A .Placebo A .DV÷DïÄHr§’DDW DÐ\HrÄsÜ......Phase 3A@DW´.DW+.12-15 YearsA YNN. DWDW´DW´AàYEARSDSAC4591001C4591001 1124 11241242112412421124.DW+B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+..DW+ AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DïÄHr§’DDW DÐ\HrÄsÜPlacebo Placebo 12-15 YearsA . . .DV÷DW ....DWŽPlacebo Placebo Placebo A .Placebo A .DV÷DïÄHr§’DDW DÐ\HrÄsÜ......Phase 3A@DW´.DW+.12-15 YearsA YNN. DWDW´DW´AàYEARSDSA C4591001C4591001 1124 11241242112412421124.DW´B¾FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APPatient is Lost toFollow-up as of June 21, 2021 DW+..DW+YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DïÄHr§’DDW DÐ\HrÄsÜPlacebo Placebo 12-15 YearsA . . .DV÷DW ....DWŽPlacebo Placebo Placebo A .Placebo A .DV÷DïÄHr§’DDW DÐ\HrÄsÜ......Phase 3A@DW´.DW+.12-15 YearsA YNN. DWDW´DW´AàYEARSDSA@C4591001C4591001 1124 11241243112412431124DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DW¼.DW0 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD¿ôHr¨³ôDW Dê$HrÄ¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD¿ôHr¨³ôDW Dê$HrÄ¤......Phase 3A@..DW0DW¼12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241243112412431124.DW0B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DW¼.DW0 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøD¿ôHr¨³ôDW Dê$HrÄ¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøD¿ôHr¨³ôDW Dê$HrÄ¤......Phase 3A@..DW0DW¼12-15 YearsAYYNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1124 11241244112412441124DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DW¼.DW/ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDË¬Hr¨¿¬DW DÄàHrÄh`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDË¬Hr¨¿¬DW DÄàHrÄh`......Phase 3A@..DW/DW¼12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1124 11241244112412441124.DW/B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DW¼.DW/ AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDË¬Hr¨¿¬DW DÄàHrÄh`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDË¬Hr¨¿¬DW DÄàHrÄh`......Phase 3A@..DW/DW¼12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1124 11241245112412451124DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DWË.DW2 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDñàHr¨åàDWDû¸HrÅð¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDñàHr¨åàDWDû¸HrÅð¸......Phase 3A@..DW2DWË12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1124 11241245112412451124.DW2B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DWË.DW2 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDñàHr¨åàDWDû¸HrÅð¸BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDñàHr¨åàDWDû¸HrÅð¸......Phase 3A@..DW2DWË12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1124 11241246112412461124DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DW½.DW2 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDñhHr¨åhDWDü0HrÅñ0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDñhHr¨åhDWDü0HrÅñ0......Phase 3A@...DW½12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1124 11241246112412461124.DW2B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DW½.DW2 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDñhHr¨åhDWDü0HrÅñ0BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDñhHr¨åhDWDü0HrÅñ0......Phase 3A@...DW½12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1124 11241247112412471124DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD‡ðHr©ÍpDWÓDåtHsÉ‘ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW¼DWÓ.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD‡ðHr©ÍpDW DÃðHrÄgpDW¼Dî Hs«H DWÓDåtHsÉ‘ôPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241247112412471124.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD‡ðHr©ÍpDWÓDåtHsÉ‘ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW¼DWÓ.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD‡ðHr©ÍpDW DÃðHrÄgpDW¼Dî Hs«H DWÓDåtHsÉ‘ôPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1124 11241247112412471124DW¼DW¼BÄREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD‡ðHr©ÍpDWÓDåtHsÉ‘ôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW .DW¼DWÓ.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD‡ðHr©ÍpDW DÃðHrÄgpDW¼Dî Hs«H DWÓDåtHsÉ‘ôPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1124 11241248112412481124DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW* AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD–Hr©Û€DW¨DÜŒHsØŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD–Hr©Û€DWD‰ÐHrÅ~ÐDW‘DÛœHsr…DW¨DÜŒHsØŒPhase 3A@..DW*.12-15 YearsAYYNN. DW…DWýDWýAÐYEARSDSAC4591001C4591001 1124 11241248112412481124.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW* AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD–Hr©Û€DW¨DÜŒHsØŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD–Hr©Û€DWD‰ÐHrÅ~ÐDW‘DÛœHsr…DW¨DÜŒHsØŒPhase 3A@..DW*.12-15 YearsAYYNN. DW…DWýDWýAÐYEARSDSA C4591001C4591001 1124 11241248112412481124DW‘DW‘B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW* AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD–Hr©Û€DW¨DÜŒHsØŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD–Hr©Û€DWD‰ÐHrÅ~ÐDW‘DÛœHsr…DW¨DÜŒHsØŒPhase 3A@..DW*.12-15 YearsAYYNN. DW…DWýDWýAÐYEARSDSA0C4591001C4591001 1124 11241248112412481124.DWÅBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW*YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD–Hr©Û€DW¨DÜŒHsØŒPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¨.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD–Hr©Û€DWD‰ÐHrÅ~ÐDW‘DÛœHsr…DW¨DÜŒHsØŒPhase 3A@..DW*.12-15 YearsAYYNN. DW…DWýDWýAÐYEARSDSA@C4591001C4591001 1124 11241249112412491124DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÒ.DW/ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÊ€HrªDWDâ¤HrÃ4¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÊ€HrªDWDâ¤HrÃ4¤......Phase 3A@..DW/DWÒ12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1124 11241249112412491124.DW/B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/DWÒ.DW/ AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÊ€HrªDWDâ¤HrÃ4¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÊ€HrªDWDâ¤HrÃ4¤......Phase 3A@..DW/DWÒ12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1124 11241250112412501124DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDä„Hr«{„DW¦Då8HsŽ>8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDä„Hr«{„DWDé4HrÇ/´DW‘DãXHsrŒØDW¦Då8HsŽ>8Phase 3A@..DW+.12-15 YearsA YNN. DW…DWýDWýAÀYEARSDSAC4591001C4591001 1124 11241250112412501124.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDä„Hr«{„DW¦Då8HsŽ>8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDä„Hr«{„DWDé4HrÇ/´DW‘DãXHsrŒØDW¦Då8HsŽ>8Phase 3A@..DW+.12-15 YearsA YNN. DW…DWýDWýAÀYEARSDSA C4591001C4591001 1124 11241250112412501124DW‘DW‘B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+ AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDä„Hr«{„DW¦Då8HsŽ>8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDä„Hr«{„DWDé4HrÇ/´DW‘DãXHsrŒØDW¦Då8HsŽ>8Phase 3A@..DW+.12-15 YearsA YNN. DW…DWýDWýAÀYEARSDSA0C4591001C4591001 1124 11241250112412501124.DWÃBÊOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÃDW+YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúDä„Hr«{„DW¦Då8HsŽ>8Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDä„Hr«{„DWDé4HrÇ/´DW‘DãXHsrŒØDW¦Då8HsŽ>8Phase 3A@..DW+.12-15 YearsA YNN. DW…DWýDWýAÀYEARSDSA@C4591001C4591001 1124 11241251112412511124DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÍ.DW, AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDŠHr¬rŒDWD¥<HrÈ=<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDŠHr¬rŒDWD¥<HrÈ=<......Phase 3A@..DW,DWÍ12-15 YearsAYYNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1124 11241251112412511124.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÍ.DW, AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDŠHr¬rŒDWD¥<HrÈ=<BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDŠHr¬rŒDWD¥<HrÈ=<......Phase 3A@..DW,DWÍ12-15 YearsAYYNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1124 11241252112412521124DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDˆhHr¬pèDW§DÆ„HsqPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDˆhHr¬pèDWD¥ðHrÈ=ðDW’DÍHssÈDW§DÆ„HsqPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241252112412521124.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDˆhHr¬pèDW§DÆ„HsqPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDˆhHr¬pèDWD¥ðHrÈ=ðDW’DÍHssÈDW§DÆ„HsqPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1124 11241252112412521124DW’DW’B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW, AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDˆhHr¬pèDW§DÆ„HsqPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDˆhHr¬pèDWD¥ðHrÈ=ðDW’DÍHssÈDW§DÆ„HsqPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1124 11241252112412521124.DWÅBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DWÅDW,YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDˆhHr¬pèDW§DÆ„HsqPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDˆhHr¬pèDWD¥ðHrÈ=ðDW’DÍHssÈDW§DÆ„HsqPhase 3A@..DW,.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1124 11241253112412531124DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÔ.DW1 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÒHr¬º€DWD§HrÈ?BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÒHr¬º€DWD§HrÈ?......Phase 3A@..DW1DWÔ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1124 11241253112412531124.DW1B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÔ.DW1 AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÒHr¬º€DWD§HrÈ?BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÒHr¬º€DWD§HrÈ?......Phase 3A@..DW1DWÔ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1124 11241254112412541124DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÛ.DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÑLHr¬¹ÌDWD¦¤HrÈ>¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÑLHr¬¹ÌDWD¦¤HrÈ>¤......Phase 3A@..DW1DWÛ12-15 YearsAYYNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1124 11241254112412541124.DW1B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÛ.DW1 AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÑLHr¬¹ÌDWD¦¤HrÈ>¤BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÑLHr¬¹ÌDWD¦¤HrÈ>¤......Phase 3A@..DW1DWÛ12-15 YearsAYYNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1124 11241255112412551124DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÉDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDí0Hr¬Õ°DW¨DÙDHsÕDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDí0Hr¬Õ°DWDê$HrÅß$DW“DÞ0Hsu*°DW¨DÙDHsÕDPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241255112412551124.DW1B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÉDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDí0Hr¬Õ°DW¨DÙDHsÕDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDí0Hr¬Õ°DWDê$HrÅß$DW“DÞ0Hsu*°DW¨DÙDHsÕDPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1124 11241255112412551124DW“DW“B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÉDW1 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDí0Hr¬Õ°DW¨DÙDHsÕDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDí0Hr¬Õ°DWDê$HrÅß$DW“DÞ0Hsu*°DW¨DÙDHsÕDPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1124 11241255112412551124.DWÉBÏOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÉDW1YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDí0Hr¬Õ°DW¨DÙDHsÕDPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDí0Hr¬Õ°DWDê$HrÅß$DW“DÞ0Hsu*°DW¨DÙDHsÕDPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1124 11241256112412561124DVþDVþASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD®$Hr°‹$DWDÞ¨HrÏ(Placebo Placebo 12-15 YearsA . . .DVþDW....DWPlacebo Placebo Placebo A .Placebo A .DVþD®$Hr°‹$DWDÞ¨HrÏ(......Phase 3A@DW•.DW1.12-15 YearsA YNN. DWŒDW•DW•AÀYEARSDSAC4591001C4591001 1124 11241256112412561124.DW1B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD®$Hr°‹$DWDÞ¨HrÏ(Placebo Placebo 12-15 YearsA . . .DVþDW....DWPlacebo Placebo Placebo A .Placebo A .DVþD®$Hr°‹$DWDÞ¨HrÏ(......Phase 3A@DW•.DW1.12-15 YearsA YNN. DWŒDW•DW•AÀYEARSDSA C4591001C4591001 1124 11241256112412561124.DW•B˜FOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APMultiple phone attempts made, certified letter sent. Subject did not complete Visit 101 DW1..DW1YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVþD®$Hr°‹$DWDÞ¨HrÏ(Placebo Placebo 12-15 YearsA . . .DVþDW....DWPlacebo Placebo Placebo A .Placebo A .DVþD®$Hr°‹$DWDÞ¨HrÏ(......Phase 3A@DW•.DW1.12-15 YearsA YNN. DWŒDW•DW•AÀYEARSDSA@C4591001C4591001 1124 11241257112412571124DVÿDVÿASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÄDW6 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDâàHr²`DW§DçHs‘˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDâàHr²`DWDÙøHrÍ·øDW‘DðxHsr™øDW§DçHs‘˜Phase 3A@..DW6.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241257112412571124.DW6B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÄDW6 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDâàHr²`DW§DçHs‘˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDâàHr²`DWDÙøHrÍ·øDW‘DðxHsr™øDW§DçHs‘˜Phase 3A@..DW6.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1124 11241257112412571124DW‘DW‘B“REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÄDW6 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDâàHr²`DW§DçHs‘˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDâàHr²`DWDÙøHrÍ·øDW‘DðxHsr™øDW§DçHs‘˜Phase 3A@..DW6.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1124 11241257112412571124.DWÄBÆOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW6.DWÄDW6YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVÿDâàHr²`DW§DçHs‘˜Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVÿDW.DW‘DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVÿDâàHr²`DWDÙøHrÍ·øDW‘DðxHsr™øDW§DçHs‘˜Phase 3A@..DW6.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1124 11241258112412581124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÃDW2 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§”Hr³'”DW§DÝ|Hs‡üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§”Hr³'”DWDá<HrÐb<DW‘DàHsr‰DW§DÝ|Hs‡üPhase 3A@..DW2.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1124 11241258112412581124.DW2B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÃDW2 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§”Hr³'”DW§DÝ|Hs‡üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§”Hr³'”DWDá<HrÐb<DW‘DàHsr‰DW§DÝ|Hs‡üPhase 3A@..DW2.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1124 11241258112412581124DW‘DW‘B’REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÃDW2 AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§”Hr³'”DW§DÝ|Hs‡üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§”Hr³'”DWDá<HrÐb<DW‘DàHsr‰DW§DÝ|Hs‡üPhase 3A@..DW2.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1124 11241258112412581124.DWÃBÄOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW2.DWÃDW2YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§”Hr³'”DW§DÝ|Hs‡üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§”Hr³'”DWDá<HrÐb<DW‘DàHsr‰DW§DÝ|Hs‡üPhase 3A@..DW2.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1124 11241259112412591124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW2DWË.DW2 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¦¤Hr³&¤DWDãXHrÐdXBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¦¤Hr³&¤DWDãXHrÐdX......Phase 3A@..DW2DWË12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241259112412591124.DW2B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW2DWË.DW2 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¦¤Hr³&¤DWDãXHrÐdXBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¦¤Hr³&¤DWDãXHrÐdX......Phase 3A@..DW2DWË12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1124 11241260112412601124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÆ.DW1 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¨ÀHr³(ÀDWDàHrÏBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¨ÀHr³(ÀDWDàHrÏ......Phase 3A@..DW1DWÆ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241260112412601124.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÆ.DW1 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¨ÀHr³(ÀDWDàHrÏBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¨ÀHr³(ÀDWDàHrÏ......Phase 3A@..DW1DWÆ12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1124 11241261112412611124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD²˜Hr³2˜DWDß˜HrÏBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD²˜Hr³2˜DWDß˜HrÏ......Phase 3A@DW¶.DW1.12-15 YearsA YNN. DWDW¶DW¶AÐYEARSDSAC4591001C4591001 1124 11241261112412611124.DW1B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1..DW1 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD²˜Hr³2˜DWDß˜HrÏBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD²˜Hr³2˜DWDß˜HrÏ......Phase 3A@DW¶.DW1.12-15 YearsA YNN. DWDW¶DW¶AÐYEARSDSA C4591001C4591001 1124 11241261112412611124.DW¶B·FOLLOW-UP BDISPOSITION EVENTWITHDRAWAL BY SUBJECT BSubject does not wish to continue in study DW1..DW1YAÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD²˜Hr³2˜DWDß˜HrÏBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD²˜Hr³2˜DWDß˜HrÏ......Phase 3A@DW¶.DW1.12-15 YearsA YNN. DWDW¶DW¶AÐYEARSDSA`C4591001C4591001 1124 11241262112412621124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8..DW8 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÎ¸Hr³N¸DWDê`HrÌvàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÎ¸Hr³N¸DWDê`HrÌvà......Phase 3A@DWÆ.DW8.12-15 YearsA YNY. DW’DWÆDWÆAðYEARSDSAC4591001C4591001 1124 11241262112412621124.DW8B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8..DW8 AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÎ¸Hr³N¸DWDê`HrÌvàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÎ¸Hr³N¸DWDê`HrÌvà......Phase 3A@DWÆ.DW8.12-15 YearsA YNY. DW’DWÆDWÆAðYEARSDSA C4591001C4591001 1124 11241262112412621124.DWÆBÇFOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APSeveral voicemails left and Certified letter sent on 7/9 DW8..DW8YAðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDÎ¸Hr³N¸DWDê`HrÌvàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDÎ¸Hr³N¸DWDê`HrÌvà......Phase 3A@DWÆ.DW8.12-15 YearsA YNY. DW’DWÆDWÆAðYEARSDSA@C4591001C4591001 1124 11241263112412631124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÉDW9 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDHrºöDW©DÔHs’!œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDHrºöDWD‹tHrÕRtDW’DÍÈHssÈÈDW©DÔHs’!œPhase 3A@..DW9.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241263112412631124.DW9B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÉDW9 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDHrºöDW©DÔHs’!œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDHrºöDWD‹tHrÕRtDW’DÍÈHssÈÈDW©DÔHs’!œPhase 3A@..DW9.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1124 11241263112412631124DW’DW’BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÉDW9 AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDHrºöDW©DÔHs’!œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDHrºöDWD‹tHrÕRtDW’DÍÈHssÈÈDW©DÔHs’!œPhase 3A@..DW9.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1124 11241263112412631124.DWÉBÄOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÉDW9YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDHrºöDW©DÔHs’!œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDHrºöDWD‹tHrÕRtDW’DÍÈHssÈÈDW©DÔHs’!œPhase 3A@..DW9.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1124 11241264112412641124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÉDW9 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÌHrºöÌDW©DÔHs’!œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌHrºöÌDWD‹8HrÕR8DW’DÎ@HssÉ@DW©DÔHs’!œPhase 3A@..DW9.12-15 YearsA YNN. DW…DWýDWýAàYEARSDSAC4591001C4591001 1124 11241264112412641124.DW9B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÉDW9 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÌHrºöÌDW©DÔHs’!œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌHrºöÌDWD‹8HrÕR8DW’DÎ@HssÉ@DW©DÔHs’!œPhase 3A@..DW9.12-15 YearsA YNN. DW…DWýDWýAàYEARSDSA C4591001C4591001 1124 11241264112412641124DW’DW’BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÉDW9 AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÌHrºöÌDW©DÔHs’!œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌHrºöÌDWD‹8HrÕR8DW’DÎ@HssÉ@DW©DÔHs’!œPhase 3A@..DW9.12-15 YearsA YNN. DW…DWýDWýAàYEARSDSA0C4591001C4591001 1124 11241264112412641124.DWÉBÄOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW9.DWÉDW9YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÌHrºöÌDW©DÔHs’!œPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW©.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÌHrºöÌDWD‹8HrÕR8DW’DÎ@HssÉ@DW©DÔHs’!œPhase 3A@..DW9.12-15 YearsA YNN. DW…DWýDWýAàYEARSDSA@C4591001C4591001 1124 11241265112412651124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÐ.DW8 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD®`Hr»`DWDŠ„HrÕQ„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD®`Hr»`DWDŠ„HrÕQ„......Phase 3A@..DW8DWÐ12-15 YearsA YNY. DWDWýDWýAàYEARSDSAC4591001C4591001 1124 11241265112412651124.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÐ.DW8 AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD®`Hr»`DWDŠ„HrÕQ„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD®`Hr»`DWDŠ„HrÕQ„......Phase 3A@..DW8DWÐ12-15 YearsA YNY. DWDWýDWýAàYEARSDSA C4591001C4591001 1124 11241266112412661124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÐ.DW8 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¯PHr»PDWDŠHrÕQBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¯PHr»PDWDŠHrÕQ......Phase 3A@..DW8DWÐ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1124 11241266112412661124.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8DWÐ.DW8 AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD¯PHr»PDWDŠHrÕQBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD¯PHr»PDWDŠHrÕQ......Phase 3A@..DW8DWÐ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1124 11241267112412671124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÃDW8 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°Hr»DW¦DäüHsŽ=üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°Hr»DWDŠHHrÕQHDW‘DðHsr™€DW¦DäüHsŽ=üPhase 3A@..DW8.12-15 YearsA YNN. DW…DWýDWýAÀYEARSDSAC4591001C4591001 1124 11241267112412671124.DW8B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÃDW8 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°Hr»DW¦DäüHsŽ=üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°Hr»DWDŠHHrÕQHDW‘DðHsr™€DW¦DäüHsŽ=üPhase 3A@..DW8.12-15 YearsA YNN. DW…DWýDWýAÀYEARSDSA C4591001C4591001 1124 11241267112412671124DW‘DW‘BŒREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÃDW8 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°Hr»DW¦DäüHsŽ=üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°Hr»DWDŠHHrÕQHDW‘DðHsr™€DW¦DäüHsŽ=üPhase 3A@..DW8.12-15 YearsA YNN. DW…DWýDWýAÀYEARSDSA0C4591001C4591001 1124 11241267112412671124.DWÃB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW8.DWÃDW8YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD°Hr»DW¦DäüHsŽ=üPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW‘DW¦.DW†Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD°Hr»DWDŠHHrÕQHDW‘DðHsr™€DW¦DäüHsŽ=üPhase 3A@..DW8.12-15 YearsA YNN. DW…DWýDWýAÀYEARSDSA@C4591001C4591001 1124 11241268112412681124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÃðHrÃðDW§DÙ¼Hs„<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÃðHrÃðDW#D¾Hráb”DW’DÑHssÌDW§DÙ¼Hs„<Phase 3A@..DWF.12-15 YearsA YNN. DWDWýDWýAàYEARSDSAC4591001C4591001 1124 11241268112412681124.DWFB;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÃðHrÃðDW§DÙ¼Hs„<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÃðHrÃðDW#D¾Hráb”DW’DÑHssÌDW§DÙ¼Hs„<Phase 3A@..DWF.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA C4591001C4591001 1124 11241268112412681124DW’DW’B‡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWF AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÃðHrÃðDW§DÙ¼Hs„<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÃðHrÃðDW#D¾Hráb”DW’DÑHssÌDW§DÙ¼Hs„<Phase 3A@..DWF.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA0C4591001C4591001 1124 11241268112412681124.DWÃB¸OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWF.DWÃDWFYAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWDÃðHrÃðDW§DÙ¼Hs„<Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW’DW§.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWDÃðHrÃðDW#D¾Hráb”DW’DÑHssÌDW§DÙ¼Hs„<Phase 3A@..DWF.12-15 YearsA YNN. DWDWýDWýAàYEARSDSA@C4591001C4591001 1124 11241269112412691124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÑ.DW? AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDçHrÃ9DW!D×dHrÞØäBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDçHrÃ9DW!D×dHrÞØä......Phase 3A@..DW?DWÑ12-15 YearsA YNY. DW=DWýDWýAðYEARSDSAC4591001C4591001 1124 11241269112412691124.DW?B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÑ.DW? AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDçHrÃ9DW!D×dHrÞØäBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW!....DW>BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDçHrÃ9DW!D×dHrÞØä......Phase 3A@..DW?DWÑ12-15 YearsA YNY. DW=DWýDWýAðYEARSDSA C4591001C4591001 1124 11241270112412701124DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWoDW> AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dá´HrÄ…4DWSD× Hs Ä Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW>DWS.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dá´HrÄ…4DW"DÑÄHrà$ÄDW>DÝ¸Hs¸DWSD× Hs Ä Phase 3A@..DW>.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSAC4591001C4591001 1124 11241270112412701124.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWoDW> AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dá´HrÄ…4DWSD× Hs Ä Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW>DWS.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dá´HrÄ…4DW"DÑÄHrà$ÄDW>DÝ¸Hs¸DWSD× Hs Ä Phase 3A@..DW>.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA C4591001C4591001 1124 11241270112412701124DW>DW>B2REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWoDW> AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dá´HrÄ…4DWSD× Hs Ä Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW>DWS.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dá´HrÄ…4DW"DÑÄHrà$ÄDW>DÝ¸Hs¸DWSD× Hs Ä Phase 3A@..DW>.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA0C4591001C4591001 1124 11241270112412701124.DWoBcOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW>.DWoDW>YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW Dá´HrÄ…4DWSD× Hs Ä Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW".DW>DWS.DW>Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW Dá´HrÄ…4DW"DÑÄHrà$ÄDW>DÝ¸Hs¸DWSD× Hs Ä Phase 3A@..DW>.12-15 YearsA YNN. DW=DWýDWýAðYEARSDSA@C4591001C4591001 1124 11241271112412711124DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÒ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DílHrÄìDW"DædHrà9dBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DílHrÄìDW"DædHrà9d......Phase 3A@..DW>DWÒ12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSAC4591001C4591001 1124 11241271112412711124.DW>B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW>DWÒ.DW> AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DW DílHrÄìDW"DædHrà9dBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DW DW"....DW“BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DW DílHrÄìDW"DædHrà9d......Phase 3A@..DW>DWÒ12-15 YearsA YNY. DW’DWýDWýAÀYEARSDSA C4591001C4591001 1124 11241272112412721124DW DW ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÊDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DñhHrÄ”èDW¨DÒxHsÎxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW#.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DñhHrÄ”èDW#DÀ0Hrád°DW’DëHssæDW¨DÒxHsÎxPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1124 11241272112412721124.DWEB9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÊDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DñhHrÄ”èDW¨DÒxHsÎxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW#.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DñhHrÄ”èDW#DÀ0Hrád°DW’DëHssæDW¨DÒxHsÎxPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1124 11241272112412721124DW’DW’B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÊDWE AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DñhHrÄ”èDW¨DÒxHsÎxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW#.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DñhHrÄ”èDW#DÀ0Hrád°DW’DëHssæDW¨DÒxHsÎxPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1124 11241272112412721124.DWÊB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DWE.DWÊDWEYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DW DñhHrÄ”èDW¨DÒxHsÎxPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DW DW#.DW’DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DW DñhHrÄ”èDW#DÀ0Hrád°DW’DëHssæDW¨DÒxHsÎxPhase 3A@..DWE.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1124 11241273112412731124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD÷¼HrÅì¼DW#Dî˜Hrá“BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD÷¼HrÅì¼DW#Dî˜Hrá“......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSAC4591001C4591001 1124 11241273112412731124.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?DWÒ.DW? AÀYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD÷¼HrÅì¼DW#Dî˜Hrá“BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD÷¼HrÅì¼DW#Dî˜Hrá“......Phase 3A@..DW?DWÒ12-15 YearsA YNY. DWDWýDWýAÀYEARSDSA C4591001C4591001 1124 11241274112412741124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWËDW? AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD÷HrÅìDW¨DîÔHsêÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD÷HrÅìDW#DìHrá„DW“DÞ¨Hsu+(DW¨DîÔHsêÔPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1124 11241274112412741124.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWËDW? AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD÷HrÅìDW¨DîÔHsêÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD÷HrÅìDW#DìHrá„DW“DÞ¨Hsu+(DW¨DîÔHsêÔPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1124 11241274112412741124DW“DW“B†REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWËDW? AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD÷HrÅìDW¨DîÔHsêÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD÷HrÅìDW#DìHrá„DW“DÞ¨Hsu+(DW¨DîÔHsêÔPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1124 11241274112412741124.DWËB¾OPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWËDW?YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD÷HrÅìDW¨DîÔHsêÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW#.DW“DW¨.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD÷HrÅìDW#DìHrá„DW“DÞ¨Hsu+(DW¨DîÔHsêÔPhase 3A@..DW?.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1124 11241275112412751124DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWADWç.DWA AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD×(HrÈo(DW#Dê`HráŽàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD×(HrÈo(DW#Dê`HráŽà......Phase 3A@..DWADWç12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1124 11241275112412751124.DWAB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWADWç.DWA AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWD×(HrÈo(DW#Dê`HráŽàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWD×(HrÈo(DW#Dê`HráŽà......Phase 3A@..DWADWç12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1125 11251241112512411125DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¸.DW# AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDøHrçøDWD…\Hr¼?ÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDøHrçøDWD…\Hr¼?Ü......Phase 3A@..DW#DW¸12-15 YearsA YNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1125 11251241112512411125.DW#B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¸.DW# AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVðDøHrçøDWD…\Hr¼?ÜBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVðDW....DW‘BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVðDøHrçøDWD…\Hr¼?Ü......Phase 3A@..DW#DW¸12-15 YearsA YNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1125 11251242112512421125DVðDVðASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD…\Hrí\DW¦Dì¸HsŽE¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD…\Hrí\DWDDHr¹–ÄDW‘DülHsr¥ìDW¦Dì¸HsŽE¸Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1125 11251242112512421125.DW(B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD…\Hrí\DW¦Dì¸HsŽE¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD…\Hrí\DWDDHr¹–ÄDW‘DülHsr¥ìDW¦Dì¸HsŽE¸Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1125 11251242112512421125DW‘DW‘B¢REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW( AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD…\Hrí\DW¦Dì¸HsŽE¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD…\Hrí\DWDDHr¹–ÄDW‘DülHsr¥ìDW¦Dì¸HsŽE¸Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1125 11251242112512421125.DWÉBÚOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW(YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVðD…\Hrí\DW¦Dì¸HsŽE¸Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVðDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVðD…\Hrí\DWDDHr¹–ÄDW‘DülHsr¥ìDW¦Dì¸HsŽE¸Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1125 11251244112512441125DVñDVñASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWâDW% AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñEF@HrŸ½äDWÆDþˆHs¸‡ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW°DWÆ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñEF@HrŸ½äDWD¡¸Hr¼\8DW°DøHs›%øDWÆDþˆHs¸‡ˆPhase 3A@..DW%.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1125 11251244112512441125.DW%B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWâDW% AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñEF@HrŸ½äDWÆDþˆHs¸‡ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW°DWÆ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñEF@HrŸ½äDWD¡¸Hr¼\8DW°DøHs›%øDWÆDþˆHs¸‡ˆPhase 3A@..DW%.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1125 11251244112512441125DW°DW°BÀREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWâDW% AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñEF@HrŸ½äDWÆDþˆHs¸‡ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW°DWÆ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñEF@HrŸ½äDWD¡¸Hr¼\8DW°DøHs›%øDWÆDþˆHs¸‡ˆPhase 3A@..DW%.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1125 11251244112512441125.DWâBòOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWâDW%YAÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVñEF@HrŸ½äDWÆDþˆHs¸‡ˆPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVñDW.DW°DWÆ.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVñEF@HrŸ½äDWD¡¸Hr¼\8DW°DøHs›%øDWÆDþˆHs¸‡ˆPhase 3A@..DW%.12-15 YearsA YNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1125 11251246112512461125DVóDVóASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDŽøHr¡ëxDWD³LHr¼mÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDŽøHr¡ëxDWD³LHr¼mÌ......Phase 3A@..DW#DW¶12-15 YearsA YNY. DWDWýDWýAÐYEARSDSAC4591001C4591001 1125 11251246112512461125.DW#B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¶.DW# AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVóDŽøHr¡ëxDWD³LHr¼mÌBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVóDW....DWŽBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVóDŽøHr¡ëxDWD³LHr¼mÌ......Phase 3A@..DW#DW¶12-15 YearsA YNY. DWDWýDWýAÐYEARSDSA C4591001C4591001 1125 11251248112512481125DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¾.DW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÊ¼Hr£x¼DWD¿Hr¼y„Placebo Placebo 12-15 YearsA . . .DVôDW....DWPlacebo Placebo Placebo A .Placebo A .DVôDÊ¼Hr£x¼DWD¿Hr¼y„......Phase 3A@..DW#DW¾12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1125 11251248112512481125.DW#B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW#DW¾.DW# AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÊ¼Hr£x¼DWD¿Hr¼y„Placebo Placebo 12-15 YearsA . . .DVôDW....DWPlacebo Placebo Placebo A .Placebo A .DVôDÊ¼Hr£x¼DWD¿Hr¼y„......Phase 3A@..DW#DW¾12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1125 11251249112512491125DVôDVôASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÉDW% AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÔHr£‚DW§DÒHs|€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÔHr£‚DWDèøHr¼£xDW‘DùØHsr£XDW§DÒHs|€Phase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1125 11251249112512491125.DW%B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÉDW% AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÔHr£‚DW§DÒHs|€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÔHr£‚DWDèøHr¼£xDW‘DùØHsr£XDW§DÒHs|€Phase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1125 11251249112512491125DW‘DW‘BžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÉDW% AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÔHr£‚DW§DÒHs|€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÔHr£‚DWDèøHr¼£xDW‘DùØHsr£XDW§DÒHs|€Phase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1125 11251249112512491125.DWÉBÖOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW%.DWÉDW%YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVôDÔHr£‚DW§DÒHs|€Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVôDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVôDÔHr£‚DWDèøHr¼£xDW‘DùØHsr£XDW§DÒHs|€Phase 3A@..DW%.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1125 11251250112512501125DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D¨üHr§K|DWDìHrÅáBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D¨üHr§K|DWDìHrÅá......Phase 3A@..DW*DW½12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1125 11251250112512501125.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D¨üHr§K|DWDìHrÅáBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D¨üHr§K|DWDìHrÅá......Phase 3A@..DW*DW½12-15 YearsA YNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1125 11251251112512511125DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D°Hr§R„DWDÉHrÅ¾BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D°Hr§R„DWDÉHrÅ¾......Phase 3A@..DW*DW½12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1125 11251251112512511125.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D°Hr§R„DWDÉHrÅ¾BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D°Hr§R„DWDÉHrÅ¾......Phase 3A@..DW*DW½12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1125 11251252112512521125DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÏ¨Hrª(DWDyàHrÎ©`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÏ¨Hrª(DWDyàHrÎ©`......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1125 11251252112512521125.DW3B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÅ.DW3 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDÏ¨Hrª(DWDyàHrÎ©`BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDÏ¨Hrª(DWDyàHrÎ©`......Phase 3A@..DW3DWÅ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1125 11251253112512531125DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÑDW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDâhHrª'èDW®D€pHs˜epPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW™DW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDâhHrª'èDWEö€HrÆhDW™D”\Hs|ÉÜDW®D€pHs˜epPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1125 11251253112512531125.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÑDW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDâhHrª'èDW®D€pHs˜epPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW™DW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDâhHrª'èDWEö€HrÆhDW™D”\Hs|ÉÜDW®D€pHs˜epPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1125 11251253112512531125DW™DW™B¡REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÑDW1 AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDâhHrª'èDW®D€pHs˜epPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW™DW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDâhHrª'èDWEö€HrÆhDW™D”\Hs|ÉÜDW®D€pHs˜epPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1125 11251253112512531125.DWÑBÙOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÑDW1YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDâhHrª'èDW®D€pHs˜epPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW™DW®.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDâhHrª'èDWEö€HrÆhDW™D”\Hs|ÉÜDW®D€pHs˜epPhase 3A@..DW1.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1125 11251254112512541125DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÉDW: AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§XHr¹¾ØDW§DçÌHs’LPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§XHr¹¾ØDWDŠÀHr×ôÀDW’DãXHssÞXDW§DçÌHs’LPhase 3A@..DW:.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1125 11251254112512541125.DW:B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÉDW: AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§XHr¹¾ØDW§DçÌHs’LPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§XHr¹¾ØDWDŠÀHr×ôÀDW’DãXHssÞXDW§DçÌHs’LPhase 3A@..DW:.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1125 11251254112512541125DW’DW’BŽREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÉDW: AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§XHr¹¾ØDW§DçÌHs’LPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§XHr¹¾ØDWDŠÀHr×ôÀDW’DãXHssÞXDW§DçÌHs’LPhase 3A@..DW:.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1125 11251254112512541125.DWÉBÅOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW:.DWÉDW:YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DWD§XHr¹¾ØDW§DçÌHs’LPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DWDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DWD§XHr¹¾ØDWDŠÀHr×ôÀDW’DãXHssÞXDW§DçÌHs’LPhase 3A@..DW:.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1125 11251255112512551125DWDWASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?..DW? AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDðHrÅåDW#Dì|HráüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDðHrÅåDW#Dì|Hráü......Phase 3A@DW×.DW?.12-15 YearsA YNY. DW×.DW×AÀYEARSDSAC4591001C4591001 1125 11251255112512551125.DW?B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?..DW? AÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDðHrÅåDW#Dì|HráüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDðHrÅåDW#Dì|Hráü......Phase 3A@DW×.DW?.12-15 YearsA YNY. DW×.DW×AÀYEARSDSA C4591001C4591001 1125 11251255112512551125.DW×BÊFOLLOW-UP BDISPOSITION EVENTLOST TO FOLLOW-UP APCertified letter sent after multiple attempts to contact for potential revax contact DW?..DW?YAÀYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DWDðHrÅåDW#Dì|HráüBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DWDW#.....BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DWDðHrÅåDW#Dì|Hráü......Phase 3A@DW×.DW?.12-15 YearsA YNY. DW×.DW×AÀYEARSDSA@C4591001C4591001 1126 11261229112612291126DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDÀäHr”îdDVþD•ÄHr°rÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDÀäHr”îdDVþD•ÄHr°rÄ......Phase 3A@..DWDW¯12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1126 11261229112612291126.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¯.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDÀäHr”îdDVþD•ÄHr°rÄBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDÀäHr”îdDVþD•ÄHr°rÄ......Phase 3A@..DWDW¯12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1126 11261230112612301013DVéDVéASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDWö.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDãXHr•ØDVþDË4Hr°¨4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDãXHr•ØDVþDË4Hr°¨4......Phase 3A@..DWDWö12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261230112612301013.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDWö.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVéDãXHr•ØDVþDË4Hr°¨4BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVéDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVéDãXHr•ØDVþDË4Hr°¨4......Phase 3A@..DWDWö12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261233112612331126DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD§”Hr–&”DW¨DÀ¨Hs¼¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD§”Hr–&”DVÿD” Hr±Â DW“D’|HstÞüDW¨DÀ¨Hs¼¨Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1126 11261233112612331126.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD§”Hr–&”DW¨DÀ¨Hs¼¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD§”Hr–&”DVÿD” Hr±Â DW“D’|HstÞüDW¨DÀ¨Hs¼¨Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1126 11261233112612331126DW“DW“BªREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDW AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD§”Hr–&”DW¨DÀ¨Hs¼¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD§”Hr–&”DVÿD” Hr±Â DW“D’|HstÞüDW¨DÀ¨Hs¼¨Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1126 11261233112612331126.DWÄBÛOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÄDWYAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêD§”Hr–&”DW¨DÀ¨Hs¼¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDVÿ.DW“DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêD§”Hr–&”DVÿD” Hr±Â DW“D’|HstÞüDW¨DÀ¨Hs¼¨Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1126 11261235112612351126DVêDVêASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÆDW AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDÜŒHr–[ŒDW§D¤LHsNÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDÜŒHr–[ŒDWDŠHHr³ HDW’DØHss‹ØDW§D¤LHsNÌPhase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1126 11261235112612351126.DWB3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÆDW AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDÜŒHr–[ŒDW§D¤LHsNÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDÜŒHr–[ŒDWDŠHHr³ HDW’DØHss‹ØDW§D¤LHsNÌPhase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1126 11261235112612351126DW’DW’B©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÆDW AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDÜŒHr–[ŒDW§D¤LHsNÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDÜŒHr–[ŒDWDŠHHr³ HDW’DØHss‹ØDW§D¤LHsNÌPhase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1126 11261235112612351126.DWÆBÝOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÆDWYAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVêDÜŒHr–[ŒDW§D¤LHsNÌPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVêDW.DW’DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVêDÜŒHr–[ŒDWDŠHHr³ HDW’DØHss‹ØDW§D¤LHsNÌPhase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1126 11261239112612391126DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDŒ Hr—] DW¦DŒ(Hså(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDŒ Hr—] DVþD{„Hr°X„DW‘D©°HsrS0DW¦DŒ(Hså(Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1126 11261239112612391126.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDŒ Hr—] DW¦DŒ(Hså(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDŒ Hr—] DVþD{„Hr°X„DW‘D©°HsrS0DW¦DŒ(Hså(Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1126 11261239112612391126DW‘DW‘B§REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDŒ Hr—] DW¦DŒ(Hså(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDŒ Hr—] DVþD{„Hr°X„DW‘D©°HsrS0DW¦DŒ(Hså(Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1126 11261239112612391126.DWÉBßOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDWYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDŒ Hr—] DW¦DŒ(Hså(Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDŒ Hr—] DVþD{„Hr°X„DW‘D©°HsrS0DW¦DŒ(Hså(Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1126 11261240112612401126DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDŒÜHr—]\DW©D·ÀHs’@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW•DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDŒÜHr—]\DVþD{HHr°XHDW•DÄhHsw³èDW©D·ÀHs’@Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1126 11261240112612401126.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDŒÜHr—]\DW©D·ÀHs’@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW•DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDŒÜHr—]\DVþD{HHr°XHDW•DÄhHsw³èDW©D·ÀHs’@Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1126 11261240112612401126DW•DW•B«REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDW AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDŒÜHr—]\DW©D·ÀHs’@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW•DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDŒÜHr—]\DVþD{HHr°XHDW•DÄhHsw³èDW©D·ÀHs’@Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1126 11261240112612401126.DWÉBßOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÉDWYAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDŒÜHr—]\DW©D·ÀHs’@Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVþ.DW•DW©.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDŒÜHr—]\DVþD{HHr°XHDW•DÄhHsw³èDW©D·ÀHs’@Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA@C4591001C4591001 1126 11261241112612411126DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD Hr—p”DVþD¬€Hr°‰€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD Hr—p”DVþD¬€Hr°‰€......Phase 3A@..DWDW12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261241112612411126.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD Hr—p”DVþD¬€Hr°‰€BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD Hr—p”DVþD¬€Hr°‰€......Phase 3A@..DWDW12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261243112612431126DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD±lHr—ìDVþD‡ðHr°dðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD±lHr—ìDVþD‡ðHr°dð......Phase 3A@..DWDW12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1126 11261243112612431126.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW.DW AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD±lHr—ìDVþD‡ðHr°dðBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVþ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD±lHr—ìDVþD‡ðHr°dð......Phase 3A@..DWDW12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1126 11261246112612461126DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD×dHr—§äDWD’Hr³BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD×dHr—§äDWD’Hr³......Phase 3A@..DWDWµ12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261246112612461126.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDWµ.DW AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëD×dHr—§äDWD’Hr³BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëD×dHr—§äDWD’Hr³......Phase 3A@..DWDWµ12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261249112612491126DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW±.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDúPHr—ÊÐDVÿDÈdHr±öäBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDúPHr—ÊÐDVÿDÈdHr±öä......Phase 3A@..DWDW±12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1126 11261249112612491126.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW±.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVëDúPHr—ÊÐDVÿDÈdHr±öäBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVëDVÿ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVëDúPHr—ÊÐDVÿDÈdHr±öä......Phase 3A@..DWDW±12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1126 11261250112612501126DVëDVëASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÍDW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDûHr—Ë„DW®DãXHs˜ÈXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW“DW®.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDûHr—Ë„DVÿDÉHr±÷˜DW“DªdHstöäDW®DãXHs˜ÈXPhase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1126 11261250112612501126.DWB4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÍDW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDûHr—Ë„DW®DãXHs˜ÈXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW“DW®.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDûHr—Ë„DVÿDÉHr±÷˜DW“DªdHstöäDW®DãXHs˜ÈXPhase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1126 11261250112612501126DW“DW“B©REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÍDW AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDûHr—Ë„DW®DãXHs˜ÈXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW“DW®.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDûHr—Ë„DVÿDÉHr±÷˜DW“DªdHstöäDW®DãXHs˜ÈXPhase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1126 11261250112612501126.DWÍBãOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÍDWYAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVëDûHr—Ë„DW®DãXHs˜ÈXPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVëDVÿ.DW“DW®.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVëDûHr—Ë„DVÿDÉHr±÷˜DW“DªdHstöäDW®DãXHs˜ÈXPhase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1126 11261253112612531126DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD±äHr˜ÓäDW§Dˆ¤Hs3$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìD±äHr˜ÓäDWD£ Hr³# DW‘DTHsr6ÔDW§Dˆ¤Hs3$Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261253112612531126.DWB1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD±äHr˜ÓäDW§Dˆ¤Hs3$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìD±äHr˜ÓäDWD£ Hr³# DW‘DTHsr6ÔDW§Dˆ¤Hs3$Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261253112612531126DW‘DW‘B¦REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDW AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD±äHr˜ÓäDW§Dˆ¤Hs3$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìD±äHr˜ÓäDWD£ Hr³# DW‘DTHsr6ÔDW§Dˆ¤Hs3$Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1126 11261253112612531126.DWÃBØOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWÃDWYAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìD±äHr˜ÓäDW§Dˆ¤Hs3$Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW.DW‘DW§.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìD±äHr˜ÓäDWD£ Hr³# DW‘DTHsr6ÔDW§Dˆ¤Hs3$Phase 3A@..DW.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1126 11261254112612541126DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWåDW? AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÜÈHr˜þÈDWÉDŒdHs¼ äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW".DWµDWÉ.DWµPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÜÈHr˜þÈDW"DÍŒHrà ŒDWµDÎ¸Hs¡î8DWÉDŒdHs¼ äPhase 3A@..DW?.12-15 YearsA YNN. DW´DWýDWýAðYEARSDSAC4591001C4591001 1126 11261254112612541126.DW?BTVACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWåDW? AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÜÈHr˜þÈDWÉDŒdHs¼ äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW".DWµDWÉ.DWµPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÜÈHr˜þÈDW"DÍŒHrà ŒDWµDÎ¸Hs¡î8DWÉDŒdHs¼ äPhase 3A@..DW?.12-15 YearsA YNN. DW´DWýDWýAðYEARSDSA C4591001C4591001 1126 11261254112612541126DWµDWµBÊREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWåDW? AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÜÈHr˜þÈDWÉDŒdHs¼ äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW".DWµDWÉ.DWµPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÜÈHr˜þÈDW"DÍŒHrà ŒDWµDÎ¸Hs¡î8DWÉDŒdHs¼ äPhase 3A@..DW?.12-15 YearsA YNN. DW´DWýDWýAðYEARSDSA0C4591001C4591001 1126 11261254112612541126.DWåBúOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW?.DWåDW?YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVìDÜÈHr˜þÈDWÉDŒdHs¼ äPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVìDW".DWµDWÉ.DWµPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVìDÜÈHr˜þÈDW"DÍŒHrà ŒDWµDÎ¸Hs¡î8DWÉDŒdHs¼ äPhase 3A@..DW?.12-15 YearsA YNN. DW´DWýDWýAðYEARSDSA@C4591001C4591001 1126 11261255112612551126DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDÝ¸Hr˜ÿ¸DWDŸØHr³ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DWµBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDÝ¸Hr˜ÿ¸DWDŸØHr³Ø......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW´DWýDWýAðYEARSDSAC4591001C4591001 1126 11261255112612551126.DW"B7VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW"DWµ.DW" AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDÝ¸Hr˜ÿ¸DWDŸØHr³ØBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDW....DWµBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDÝ¸Hr˜ÿ¸DWDŸØHr³Ø......Phase 3A@..DW"DWµ12-15 YearsAYYNY. DW´DWýDWýAðYEARSDSA C4591001C4591001 1126 11261258112612581126DVìDVìASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW¼.DW AÐYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDùœHr™œDVÿD‡ðHr±¶pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW¼BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDùœHr™œDVÿD‡ðHr±¶p......Phase 3A@..DWDW¼12-15 YearsA YNY. DW»DWýDWýAÐYEARSDSAC4591001C4591001 1126 11261258112612581126.DWB2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW¼.DW AÐYEARSFA MULTIPLE A`MULTIRACIAL A`YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVìDùœHr™œDVÿD‡ðHr±¶pBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVìDVÿ....DW¼BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVìDùœHr™œDVÿD‡ðHr±¶p......Phase 3A@..DWDW¼12-15 YearsA YNY. DW»DWýDWýAÐYEARSDSA C4591001C4591001 1126 11261262112612621126DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW.DWbDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDãHršVœDWFD®œHswœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW1DWF.DW0Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDãHršVœDWD½œHr³=œDW1DÒxHróëøDWFD®œHswœPhase 3A@..DW.12-15 YearsA YNN. DW/DWýDWýAðYEARSDSAC4591001C4591001 1126 11261262112612621126.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWbDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDãHršVœDWFD®œHswœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW1DWF.DW0Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDãHršVœDWD½œHr³=œDW1DÒxHróëøDWFD®œHswœPhase 3A@..DW.12-15 YearsA YNN. DW/DWýDWýAðYEARSDSA C4591001C4591001 1126 11261262112612621126DW1DW1BEREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWbDW AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDãHršVœDWFD®œHswœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW1DWF.DW0Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDãHršVœDWD½œHr³=œDW1DÒxHróëøDWFD®œHswœPhase 3A@..DW.12-15 YearsA YNN. DW/DWýDWýAðYEARSDSA0C4591001C4591001 1126 11261262112612621126.DWbBvOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW.DWbDWYAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVíDãHršVœDWFD®œHswœPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVíDW.DW1DWF.DW0Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVíDãHršVœDWD½œHr³=œDW1DÒxHróëøDWFD®œHswœPhase 3A@..DW.12-15 YearsA YNN. DW/DWýDWýAðYEARSDSA@C4591001C4591001 1126 11261263112612631126DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DWDW·.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDìôHrš`tDWDÜHr³\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW·BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDìôHrš`tDWDÜHr³\......Phase 3A@..DWDW·12-15 YearsA YNY. DW¶DWýDWýAðYEARSDSAC4591001C4591001 1126 11261263112612631126.DWB0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DWDW·.DW AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDìôHrš`tDWDÜHr³\BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DW·BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDìôHrš`tDWDÜHr³\......Phase 3A@..DWDW·12-15 YearsA YNY. DW¶DWýDWýAðYEARSDSA C4591001C4591001 1126 11261264112612641126DVíDVíASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¸.DW! AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDûHršn„DWDÊHr³JBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDûHršn„DWDÊHr³J......Phase 3A@..DW!DW¸12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261264112612641126.DW!B5VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW!DW¸.DW! AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVíDûHršn„DWDÊHr³JBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVíDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVíDûHršn„DWDÊHr³J......Phase 3A@..DW!DW¸12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261265112612651126DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷Dÿ<Hr§¡¼DWDª(Hs—=¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW“DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷Dÿ<Hr§¡¼DWD€èHrÂÒèDW“DÃHsu€DWDª(Hs—=¨Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1126 11261265112612651126.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷Dÿ<Hr§¡¼DWDª(Hs—=¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW“DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷Dÿ<Hr§¡¼DWD€èHrÂÒèDW“DÃHsu€DWDª(Hs—=¨Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1126 11261265112612651126DW“DW“BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW( AàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷Dÿ<Hr§¡¼DWDª(Hs—=¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW“DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷Dÿ<Hr§¡¼DWD€èHrÂÒèDW“DÃHsu€DWDª(Hs—=¨Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1126 11261265112612651126.DWÉBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW(YAàYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷Dÿ<Hr§¡¼DWDª(Hs—=¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW“DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷Dÿ<Hr§¡¼DWD€èHrÂÒèDW“DÃHsu€DWDª(Hs—=¨Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1126 11261266112612661126DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW( AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D†ˆHr§)DWDª Hs—> Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW“DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D†ˆHr§)DWD`HrÂÓ`DW“DÃHsu€DWDª Hs—> Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1126 11261266112612661126.DW(B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW( AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D†ˆHr§)DWDª Hs—> Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW“DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D†ˆHr§)DWD`HrÂÓ`DW“DÃHsu€DWDª Hs—> Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1126 11261266112612661126DW“DW“BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW( AÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D†ˆHr§)DWDª Hs—> Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW“DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D†ˆHr§)DWD`HrÂÓ`DW“DÃHsu€DWDª Hs—> Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1126 11261266112612661126.DWÉBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW(.DWÉDW(YAÀYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷D†ˆHr§)DWDª Hs—> Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW“DW.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷D†ˆHr§)DWD`HrÂÓ`DW“DÃHsu€DWDª Hs—> Phase 3A@..DW(.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1126 11261267112612671126DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÉDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DØHr§3XDWªDˆàHs“'àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DØHr§3XDWDå°HrÃ7°DW•DÞlHswÍìDWªDˆàHs“'àPhase 3A@..DW*.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261267112612671126.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÉDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DØHr§3XDWªDˆàHs“'àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DØHr§3XDWDå°HrÃ7°DW•DÞlHswÍìDWªDˆàHs“'àPhase 3A@..DW*.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261267112612671126DW•DW•BŸREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÉDW* AÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DØHr§3XDWªDˆàHs“'àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DØHr§3XDWDå°HrÃ7°DW•DÞlHswÍìDWªDˆàHs“'àPhase 3A@..DW*.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA0C4591001C4591001 1126 11261267112612671126.DWÉBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÉDW*YAÐYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DØHr§3XDWªDˆàHs“'àPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW•DWª.DW‘Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DØHr§3XDWDå°HrÃ7°DW•DÞlHswÍìDWªDˆàHs“'àPhase 3A@..DW*.12-15 YearsAYYNN. DWDWýDWýAÐYEARSDSA@C4591001C4591001 1126 11261268112612681126DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DœHr§?DW Dâ,HrÄ…¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DœHr§?DW Dâ,HrÄ…¬......Phase 3A@..DW,DWÄ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261268112612681126.DW,B6VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DœHr§?DW Dâ,HrÄ…¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW ....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DœHr§?DW Dâ,HrÄ…¬......Phase 3A@..DW,DWÄ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261269112612691126DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÉ.DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D·ÀHr§Z@DWD¤LHrÅ™LBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D·ÀHr§Z@DWD¤LHrÅ™L......Phase 3A@..DW*DWÉ12-15 YearsAYYNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1126 11261269112612691126.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÉ.DW* AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷D·ÀHr§Z@DWD¤LHrÅ™LBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷D·ÀHr§Z@DWD¤LHrÅ™L......Phase 3A@..DW*DWÉ12-15 YearsAYYNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1126 11261270112612701126DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW* AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÐ Hr§r DW©D‹tHs‘ØôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÐ Hr§r DWD¨üHrÅüDW”DâàHsv€àDW©D‹tHs‘ØôPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1126 11261270112612701126.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW* AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÐ Hr§r DW©D‹tHs‘ØôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÐ Hr§r DWD¨üHrÅüDW”DâàHsv€àDW©D‹tHs‘ØôPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1126 11261270112612701126DW”DW”BžREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW* AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÐ Hr§r DW©D‹tHs‘ØôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÐ Hr§r DWD¨üHrÅüDW”DâàHsv€àDW©D‹tHs‘ØôPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1126 11261270112612701126.DWÅBÏOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÅDW*YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DV÷DÐ Hr§r DW©D‹tHs‘ØôPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DV÷DW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DV÷DÐ Hr§r DWD¨üHrÅüDW”DâàHsv€àDW©D‹tHs‘ØôPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1126 11261271112612711126DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÍ.DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DäÀHr§‡@DWDÈdHrÅ½dBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DäÀHr§‡@DWDÈdHrÅ½d......Phase 3A@..DW*DWÍ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1126 11261271112612711126.DW*B4VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DWÍ.DW* AðYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷DäÀHr§‡@DWDÈdHrÅ½dBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷DäÀHr§‡@DWDÈdHrÅ½d......Phase 3A@..DW*DWÍ12-15 YearsA YNY. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1126 11261273112612731126DV÷DV÷ASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÊ.DW0 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dû¸Hr§ž8DWDí¨HrÅâ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dû¸Hr§ž8DWDí¨HrÅâ¨......Phase 3A@..DW0DWÊ12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261273112612731126.DW0B:VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW0DWÊ.DW0 AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DV÷Dû¸Hr§ž8DWDí¨HrÅâ¨BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DV÷DW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DV÷Dû¸Hr§ž8DWDí¨HrÅâ¨......Phase 3A@..DW0DWÊ12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261274112612741126DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÊDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDªÜHr¨žÜDW©EE@Hs’aÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDªÜHr¨žÜDWD›dHrÂídDW”Dæ Hsv„ DW©EE@Hs’aÔPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1126 11261274112612741126.DW*B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÊDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDªÜHr¨žÜDW©EE@Hs’aÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDªÜHr¨žÜDWD›dHrÂídDW”Dæ Hsv„ DW©EE@Hs’aÔPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1126 11261274112612741126DW”DW”BREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÊDW* AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDªÜHr¨žÜDW©EE@Hs’aÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDªÜHr¨žÜDWD›dHrÂídDW”Dæ Hsv„ DW©EE@Hs’aÔPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1126 11261274112612741126.DWÊBÓOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÊDW*YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDªÜHr¨žÜDW©EE@Hs’aÔPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW”DW©.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDªÜHr¨žÜDWD›dHrÂídDW”Dæ Hsv„ DW©EE@Hs’aÔPhase 3A@..DW*.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1126 11261275112612751126DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWgDW/ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDæÜHr¨ÚÜDWFD¼4Hs…4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW/DWF.DW+Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDæÜHr¨ÚÜDWDñ¤HrÅæ¤DW/DáHrñW€DWFD¼4Hs…4Phase 3A@..DW/.12-15 YearsA YNN. DW*DWýDWýAðYEARSDSAC4591001C4591001 1126 11261275112612751126DW/DW/B8REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWgDW/ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDæÜHr¨ÚÜDWFD¼4Hs…4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW/DWF.DW+Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDæÜHr¨ÚÜDWDñ¤HrÅæ¤DW/DáHrñW€DWFD¼4Hs…4Phase 3A@..DW/.12-15 YearsA YNN. DW*DWýDWýAðYEARSDSA C4591001C4591001 1126 11261275112612751126.DW/B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWgDW/ AðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDæÜHr¨ÚÜDWFD¼4Hs…4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW/DWF.DW+Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDæÜHr¨ÚÜDWDñ¤HrÅæ¤DW/DáHrñW€DWFD¼4Hs…4Phase 3A@..DW/.12-15 YearsA YNN. DW*DWýDWýAðYEARSDSA0C4591001C4591001 1126 11261275112612751126.DWgBpOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWgDW/YAðYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDæÜHr¨ÚÜDWFD¼4Hs…4Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW/DWF.DW+Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDæÜHr¨ÚÜDWDñ¤HrÅæ¤DW/DáHrñW€DWFD¼4Hs…4Phase 3A@..DW/.12-15 YearsA YNN. DW*DWýDWýAðYEARSDSA@C4591001C4591001 1126 11261276112612761126DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWgDW/ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDçHr¨ÛDWFD»øHs„øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW/DWF.DW+Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDçHr¨ÛDWDñ¤HrÅæ¤DW/Dá<HrñW¼DWFD»øHs„øPhase 3A@..DW/.12-15 YearsA YNN. DW*DWýDWýAðYEARSDSAC4591001C4591001 1126 11261276112612761126DW/DW/B8REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWgDW/ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDçHr¨ÛDWFD»øHs„øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW/DWF.DW+Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDçHr¨ÛDWDñ¤HrÅæ¤DW/Dá<HrñW¼DWFD»øHs„øPhase 3A@..DW/.12-15 YearsA YNN. DW*DWýDWýAðYEARSDSA C4591001C4591001 1126 11261276112612761126.DW/B8VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWgDW/ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDçHr¨ÛDWFD»øHs„øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW/DWF.DW+Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDçHr¨ÛDWDñ¤HrÅæ¤DW/Dá<HrñW¼DWFD»øHs„øPhase 3A@..DW/.12-15 YearsA YNN. DW*DWýDWýAðYEARSDSA0C4591001C4591001 1126 11261276112612761126.DWgBpOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW/.DWgDW/YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVøDçHr¨ÛDWFD»øHs„øPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVøDW.DW/DWF.DW+Placebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVøDçHr¨ÛDWDñ¤HrÅæ¤DW/Dá<HrñW¼DWFD»øHs„øPhase 3A@..DW/.12-15 YearsA YNN. DW*DWýDWýAðYEARSDSA@C4591001C4591001 1126 11261277112612771126DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÊ.DW) AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDïˆHr¨ãˆDW DÍŒHrÄqBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW€BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDïˆHr¨ãˆDW DÍŒHrÄq......Phase 3A@..DW)DWÊ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1126 11261277112612771126.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÊ.DW) AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDïˆHr¨ãˆDW DÍŒHrÄqBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW€BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDïˆHr¨ãˆDW DÍŒHrÄq......Phase 3A@..DW)DWÊ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1126 11261278112612781126DVøDVøASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÊ.DW) AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDû|Hr¨ï|DW DÎHrÄq„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW€BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDû|Hr¨ï|DW DÎHrÄq„......Phase 3A@..DW)DWÊ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSAC4591001C4591001 1126 11261278112612781126.DW)B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW)DWÊ.DW) AðYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVøDû|Hr¨ï|DW DÎHrÄq„BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVøDW ....DW€BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVøDû|Hr¨ï|DW DÎHrÄq„......Phase 3A@..DW)DWÊ12-15 YearsAYYNY. DWDWýDWýAðYEARSDSA C4591001C4591001 1126 11261279112612791126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD‹tHr©ÐôDWªD·ÀHs“VÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD‹tHr©ÐôDWDÙ€HrÇ DW”DÇ°Hsve°DWªD·ÀHs“VÀPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAðYEARSDSAC4591001C4591001 1126 11261279112612791126.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD‹tHr©ÐôDWªD·ÀHs“VÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD‹tHr©ÐôDWDÙ€HrÇ DW”DÇ°Hsve°DWªD·ÀHs“VÀPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA C4591001C4591001 1126 11261279112612791126DW”DW”BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+ AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD‹tHr©ÐôDWªD·ÀHs“VÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD‹tHr©ÐôDWDÙ€HrÇ DW”DÇ°Hsve°DWªD·ÀHs“VÀPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA0C4591001C4591001 1126 11261279112612791126.DWÆBÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùD‹tHr©ÐôDWªD·ÀHs“VÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùD‹tHr©ÐôDWDÙ€HrÇ DW”DÇ°Hsve°DWªD·ÀHs“VÀPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAðYEARSDSA@C4591001C4591001 1126 11261280112612801126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŒ(Hr©Ñ¨DWªD·üHs“VüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŒ(Hr©Ñ¨DWDÚpHrÇ ðDW”DÈ(Hsvf(DWªD·üHs“VüPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSAC4591001C4591001 1126 11261280112612801126.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŒ(Hr©Ñ¨DWªD·üHs“VüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŒ(Hr©Ñ¨DWDÚpHrÇ ðDW”DÈ(Hsvf(DWªD·üHs“VüPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA C4591001C4591001 1126 11261280112612801126DW”DW”BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+ AÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŒ(Hr©Ñ¨DWªD·üHs“VüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŒ(Hr©Ñ¨DWDÚpHrÇ ðDW”DÈ(Hsvf(DWªD·üHs“VüPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA0C4591001C4591001 1126 11261280112612801126.DWÆBÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÆDW+YAÀYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDŒ(Hr©Ñ¨DWªD·üHs“VüPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW”DWª.DWŽPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDŒ(Hr©Ñ¨DWDÚpHrÇ ðDW”DÈ(Hsvf(DWªD·üHs“VüPhase 3A@..DW+.12-15 YearsA YNN. DWDWýDWýAÀYEARSDSA@C4591001C4591001 1126 11261281112612811126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÌ.DW3 AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¤ÄHr©êDDWDædHrÇ,äBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¤ÄHr©êDDWDædHrÇ,ä......Phase 3A@..DW3DWÌ12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1126 11261281112612811126.DW3B;VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW3DWÌ.DW3 AÀYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD¤ÄHr©êDDWDædHrÇ,äBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD¤ÄHr©êDDWDædHrÇ,ä......Phase 3A@..DW3DWÌ12-15 YearsAYYNY. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1126 11261282112612821126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD«Hr©ð˜DWD PHrÅ•PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD«Hr©ð˜DWD PHrÅ•P......Phase 3A@..DW*DW½12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261282112612821126.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AÐYEARSFA ASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùD«Hr©ð˜DWD PHrÅ•PBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùD«Hr©ð˜DWD PHrÅ•P......Phase 3A@..DW*DW½12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261283112612831126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVùDÉTHrªÔDW¨DÑLHsÍLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÉTHrªÔDWDÜPHrÅÑPDW‘Dæ Hsr DW¨DÑLHsÍLPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261283112612831126.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVùDÉTHrªÔDW¨DÑLHsÍLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÉTHrªÔDWDÜPHrÅÑPDW‘Dæ Hsr DW¨DÑLHsÍLPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261283112612831126DW‘DW‘B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1 AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVùDÉTHrªÔDW¨DÑLHsÍLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÉTHrªÔDWDÜPHrÅÑPDW‘Dæ Hsr DW¨DÑLHsÍLPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1126 11261283112612831126.DWÄBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÄDW1YAÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVùDÉTHrªÔDW¨DÑLHsÍLPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÉTHrªÔDWDÜPHrÅÑPDW‘Dæ Hsr DW¨DÑLHsÍLPhase 3A@..DW1.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1126 11261284112612841126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÆDW* AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVùDÓàHrª`DW¦DÕÀHsŽ.ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÓàHrª`DWDÖìHrÅËìDW‘DÛØHsr…XDW¦DÕÀHsŽ.ÀPhase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261284112612841126.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÆDW* AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVùDÓàHrª`DW¦DÕÀHsŽ.ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÓàHrª`DWDÖìHrÅËìDW‘DÛØHsr…XDW¦DÕÀHsŽ.ÀPhase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261284112612841126DW‘DW‘B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÆDW* AÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVùDÓàHrª`DW¦DÕÀHsŽ.ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÓàHrª`DWDÖìHrÅËìDW‘DÛØHsr…XDW¦DÕÀHsŽ.ÀPhase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA0C4591001C4591001 1126 11261284112612841126.DWÆBÎOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÆDW*YAÐYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVùDÓàHrª`DW¦DÕÀHsŽ.ÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVùDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDÓàHrª`DWDÖìHrÅËìDW‘DÛØHsr…XDW¦DÕÀHsŽ.ÀPhase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAÐYEARSDSA@C4591001C4591001 1126 11261285112612851126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDïˆHrª5DWD¬HrÅ„¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDïˆHrª5DWD¬HrÅ„¬......Phase 3A@..DW*DW½12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1126 11261285112612851126.DW*B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*DW½.DW* AàYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDïˆHrª5DWD¬HrÅ„¬BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDïˆHrª5DWD¬HrÅ„¬......Phase 3A@..DW*DW½12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1126 11261286112612861126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÄ.DW1 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDðxHrª5øDWD½`HrÎìàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDðxHrª5øDWD½`HrÎìà......Phase 3A@..DW1DWÄ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261286112612861126.DW1B9VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW1DWÄ.DW1 AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDðxHrª5øDWD½`HrÎìàBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDðxHrª5øDWD½`HrÎìà......Phase 3A@..DW1DWÄ12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261287112612871126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÅDW1 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDððHrª6pDW©D¡Hs‘î„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVù..DW”DW©.DWPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDððHrª6pDVùDððHrª6pDW”D§XHsvEXDW©D¡Hs‘î„Phase 3A@.DWDW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSAC4591001C4591001 1126 11261287112612871126DW”DW”BœREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÅDW1 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDððHrª6pDW©D¡Hs‘î„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVù..DW”DW©.DWPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDððHrª6pDVùDððHrª6pDW”D§XHsvEXDW©D¡Hs‘î„Phase 3A@.DWDW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA C4591001C4591001 1126 11261287112612871126.DWÅBÍOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW1.DWÅDW1YAðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDððHrª6pDW©D¡Hs‘î„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVù..DW”DW©.DWPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDððHrª6pDVùDððHrª6pDW”D§XHsvEXDW©D¡Hs‘î„Phase 3A@.DWDW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA0C4591001C4591001 1126 11261287112612871126.DWAðVACCINATION BDISPOSITION EVENTNO LONGER MEETS ELIGIBILITY CRITERIABSubject did not receive 2nd vaccine due to Covid 19 disease. DW1.DWÅDW1 AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVùDððHrª6pDW©D¡Hs‘î„Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVù..DW”DW©.DWPlacebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVùDððHrª6pDVùDððHrª6pDW”D§XHsvEXDW©D¡Hs‘î„Phase 3A@.DWDW1.12-15 YearsA YNN. DWŒDWýDWýAðYEARSDSA`C4591001C4591001 1126 11261288112612881126DVùDVùASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÃ.DW+ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDôìHrª:lDWD¦,HrÅ›,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDôìHrª:lDWD¦,HrÅ›,......Phase 3A@....12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261288112612881126.DW+B3VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÃ.DW+ AÐYEARSMAWHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVùDôìHrª:lDWD¦,HrÅ›,BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVùDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVùDôìHrª:lDWD¦,HrÅ›,......Phase 3A@....12-15 YearsA YNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261289112612891126DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÄDW* AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD»DHr«RDDW¨DÐ\HsÌ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD»DHr«RDDWDÍPHrÅÂPDW‘DÐ Hsry DW¨DÐ\HsÌ\Phase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1126 11261289112612891126.DW*B1VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÄDW* AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD»DHr«RDDW¨DÐ\HsÌ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD»DHr«RDDWDÍPHrÅÂPDW‘DÐ Hsry DW¨DÐ\HsÌ\Phase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1126 11261289112612891126DW‘DW‘B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÄDW* AàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD»DHr«RDDW¨DÐ\HsÌ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD»DHr«RDDWDÍPHrÅÂPDW‘DÐ Hsry DW¨DÐ\HsÌ\Phase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA0C4591001C4591001 1126 11261289112612891126.DWÄBËOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW*.DWÄDW*YAàYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVúD»DHr«RDDW¨DÐ\HsÌ\Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúD»DHr«RDDWDÍPHrÅÂPDW‘DÐ Hsry DW¨DÐ\HsÌ\Phase 3A@..DW*.12-15 YearsA YNN. DWŒDWýDWýAàYEARSDSA@C4591001C4591001 1126 11261290112612901126DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÍDW) AÀYEARSMANOT REPORTED ApNOT REPORTED ApYYPlacebo PLACEBO Placebo PLACEBO DVúDãÐHr«zÐDW¨DÆÀHsÂÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDãÐHr«zÐDW DÏ¨HrÄs(DW’DÙøHssÔøDW¨DÆÀHsÂÀPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1126 11261290112612901126.DW)B0VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÍDW) AÀYEARSMANOT REPORTED ApNOT REPORTED ApYYPlacebo PLACEBO Placebo PLACEBO DVúDãÐHr«zÐDW¨DÆÀHsÂÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDãÐHr«zÐDW DÏ¨HrÄs(DW’DÙøHssÔøDW¨DÆÀHsÂÀPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1126 11261290112612901126DW’DW’B™REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÍDW) AÀYEARSMANOT REPORTED ApNOT REPORTED ApYYPlacebo PLACEBO Placebo PLACEBO DVúDãÐHr«zÐDW¨DÆÀHsÂÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDãÐHr«zÐDW DÏ¨HrÄs(DW’DÙøHssÔøDW¨DÆÀHsÂÀPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1126 11261290112612901126.DWÍBÔOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW).DWÍDW)YAÀYEARSMANOT REPORTED ApNOT REPORTED ApYYPlacebo PLACEBO Placebo PLACEBO DVúDãÐHr«zÐDW¨DÆÀHsÂÀPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW .DW’DW¨.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDãÐHr«zÐDW DÏ¨HrÄs(DW’DÙøHssÔøDW¨DÆÀHsÂÀPhase 3A@..DW).12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1126 11261291112612911126DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÌ.DW+ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÚèHr«qèDWDØHrÇBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÚèHr«qèDWDØHrÇ......Phase 3A@..DW+DWÌ12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261291112612911126.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+DWÌ.DW+ AÐYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVúDÚèHr«qèDWDØHrÇBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVúDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVúDÚèHr«qèDWDØHrÇ......Phase 3A@..DW+DWÌ12-15 YearsAYYNY. DWŒDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261292112612921126DVúDVúASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÅDW+ AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDóüHr«ŠüDW¦D¢¨Hsû¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDóüHr«ŠüDWDäüHrÇ+|DW‘D½$Hsrf¤DW¦D¢¨Hsû¨Phase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSAC4591001C4591001 1126 11261292112612921126.DW+B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÅDW+ AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDóüHr«ŠüDW¦D¢¨Hsû¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDóüHr«ŠüDWDäüHrÇ+|DW‘D½$Hsrf¤DW¦D¢¨Hsû¨Phase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA C4591001C4591001 1126 11261292112612921126DW‘DW‘B˜REPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÅDW+ AÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDóüHr«ŠüDW¦D¢¨Hsû¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDóüHr«ŠüDWDäüHrÇ+|DW‘D½$Hsrf¤DW¦D¢¨Hsû¨Phase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA0C4591001C4591001 1126 11261292112612921126.DWÅBÌOPEN LABEL TREATMENTApDISPOSITION EVENTCOMPLETED A COMPLETED DW+.DWÅDW+YAÀYEARSFA ASIAN A@ASIAN A@YYPlacebo PLACEBO Placebo PLACEBO DVúDóüHr«ŠüDW¦D¢¨Hsû¨Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVúDW.DW‘DW¦.DWPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVúDóüHr«ŠüDWDäüHrÇ+|DW‘D½$Hsrf¤DW¦D¢¨Hsû¨Phase 3A@..DW+.12-15 YearsA YNN. DWŒDWýDWýAÀYEARSDSA@C4591001C4591001 1126 11261293112612931126DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÍ.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD€pHr¬hðDWDðHrÈˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD€pHr¬hðDWDðHrÈˆ......Phase 3A@..DW,DWÍ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1126 11261293112612931126.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÍ.DW, AàYEARSFA WHITE AWHITE AYYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûD€pHr¬hðDWDðHrÈˆBNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûD€pHr¬hðDWDðHrÈˆ......Phase 3A@..DW,DWÍ12-15 YearsAYYNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1126 11261294112612941126DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÃ.DW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD§Hr¬œDWâD’|HsÝ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWÍDWâ.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD§Hr¬œDWD¼¬HrÈT¬DWÍD«ÌHsÁoLDWâD’|HsÝ|Phase 3A@..DW,DWÃ12-15 YearsA YNN. DWÂDWýDWýAÐYEARSDSAC4591001C4591001 1126 11261294112612941126.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÃ.DW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD§Hr¬œDWâD’|HsÝ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWÍDWâ.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD§Hr¬œDWD¼¬HrÈT¬DWÍD«ÌHsÁoLDWâD’|HsÝ|Phase 3A@..DW,DWÃ12-15 YearsA YNN. DWÂDWýDWýAÐYEARSDSA C4591001C4591001 1126 11261294112612941126DWÍDWÍBÓREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÃ.DW, AÐYEARSFA WHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûD§Hr¬œDWâD’|HsÝ|Placebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWÍDWâ.DWÃPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûD§Hr¬œDWD¼¬HrÈT¬DWÍD«ÌHsÁoLDWâD’|HsÝ|Phase 3A@..DW,DWÃ12-15 YearsA YNN. DWÂDWýDWýAÐYEARSDSA0C4591001C4591001 1126 11261295112612951126DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÁ\Hr¬©ÜDWDÛ$HrÈs$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÁ\Hr¬©ÜDWDÛ$HrÈs$......Phase 3A@..DW,DWÄ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSAC4591001C4591001 1126 11261295112612951126.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,DWÄ.DW, AàYEARSMAASIAN A@ASIAN A@YYBNT162b2 Phase 2/3 (30 mcg)B2_P23_30BNT162b2 Phase 2/3 (30 mcg)B2_P23_30DVûDÁ\Hr¬©ÜDWDÛ$HrÈs$BNT162b2 Phase 2/3 (30 mcg) BNT162b2 Phase 2/3 (30 mcg) 12-15 YearsA . . .DVûDW....DWBNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) BNT162b2 Phase 2/3 (30 mcg)A€ .BNT162b2 Phase 2/3 (30 mcg)A€ .DVûDÁ\Hr¬©ÜDWDÛ$HrÈs$......Phase 3A@..DW,DWÄ12-15 YearsA YNY. DWŒDWýDWýAàYEARSDSA C4591001C4591001 1126 11261296112612961126DVûDVûASCREENING ADISPOSITION EVENTCOMPLETED A COMPLETED DW,.DW˜DW, AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÛ$Hr¬Ã¤DW|DÖtHsVÐtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWiDW|.DWhPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÛ$Hr¬Ã¤DWDÞ¨HrÈv¨DWiD•ÄHs=ƒDDW|DÖtHsVÐtPhase 3A@..DW,.12-15 YearsA YNN. DWgDWýDWýAðYEARSDSAC4591001C4591001 1126 11261296112612961126.DW,B2VACCINATION BDISPOSITION EVENTCOMPLETED A COMPLETED DW,.DW˜DW, AðYEARSMAWHITE AWHITE AYYPlacebo PLACEBO Placebo PLACEBO DVûDÛ$Hr¬Ã¤DW|DÖtHsVÐtPlacebo => BNT162b2 Phase 2/3 (30 mcg)Placebo => BNT162b2 Phase 2/3 (30 mcg)12-15 YearsA . . .DVûDW.DWiDW|.DWhPlacebo Placebo BNT162b2 (30 (*ESC*){unicode 03BC}g)BNT162b2 (30 (*ESC*){unicode 03BC}g) Placebo ABNT162b2 Phase 2/3 (30 mcg)A€Placebo ABNT162b2 Phase 2/3 (30 mcg)A€DVûDÛ$Hr¬Ã¤DWDÞ¨HrÈv¨DWiD•ÄHs=ƒDDW|DÖtHsVÐtPhase 3A@..DW,.12-15 YearsA YNN. DWgDWýDWýAðYEARSDSA C4591001C4591001 1126 11261296112612961126DWiDWiBoREPEAT SCREENING 1 BeDISPOSITION EVENTCOMPLETED A COMPLETED